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https://www.readbyqxmd.com/read/29655974/tacs-mediated-modulation-of-the-auditory-steady-state-response-as-seen-with-meg
#1
Petteri Hyvärinen, Dawoon Choi, Gianpaolo Demarchi, Antti A Aarnisalo, Nathan Weisz
BACKGROUND: Previous studies have shown that transcranial electrical stimulation can be successfully applied during simultaneous MEG measurements. In particular, using beamforming they have established that changes of stimulus induced as well as evoked activity can be inspected during transcranial alternating current stimulation (tACS). OBJECTIVE/HYPOTHESIS: We studied tACS-mediated changes of the auditory steady-state response (ASSR), hypothesizing that-due to the putatively inhibitory role of alpha oscillations-these evoked responses would be diminished...
March 28, 2018: Hearing Research
https://www.readbyqxmd.com/read/29655957/ectopic-cushing-syndrome-report-of-9-cases
#2
Marta Araujo Castro, Nuria Palacios García, Javier Aller Pardo, Cristina Izquierdo Alvarez, Laura Armengod Grao, Javier Estrada García
INTRODUCTION: Ectopic Cushing's syndrome (ECS) is a rare condition caused by ACTH secretion by extrapituitary tumors. Its low frequency makes it difficult to acquire experience in its management. The aim of this study was to describe patients with ECS seen at the endocrinology department of a tertiary hospital over 15 years. METHODS: This was a retrospective study of the clinical, biochemical and radiographic data, treatment, and course of patients with ECS seen from 2000 to 2015...
April 11, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29652523/attitudes-on-technological-social-and-behavioral-economic-strategies-to-reduce-cellphone-use-while-driving-in-teens
#3
M Kit Delgado, Catherine C McDonald, Flaura K Winston, Scott D Halpern, Alison M Buttenheim, Claudia Setubal, Yanlan Huang, Kathryn A Saulsgiver, Yi-Ching Lee
OBJECTIVE: The majority of U.S. teens admit to handheld cellphone use while driving, an increasingly common cause of crashes. Attitudes towards novel cellphone applications and settings that block use while driving are poorly understood, potentially limiting uptake. We examined teens' willingness to reduce cellphone use while driving and perceptions of potential strategies to limit this behavior. METHODS: Teen drivers (n = 153) aged 16-17 who owned smartphones and admitted to texting while driving completed an online survey...
April 13, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29651891/use-of-vagus-nerve-stimulator-on-children-with-primary-generalized-epilepsy
#4
William P Welch, Bilal Sitwat, Yoshimi Sogawa
OBJECTIVE: To describe the response to vagus nerve stimulator (VNS) in otherwise neurotypical children with medically intractable primary generalized epilepsy. METHODS: Retrospective chart review of patients who underwent vagus nerve stimulator surgery between January 2011 and December 2015. RESULTS: Eleven patients were identified. Median follow-up duration was 2.5 years (1.2-8.4 years). Prior to vagus nerve stimulator surgery, all patients had at least 1 seizure per week, and 7/11 (64%) had daily seizures...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29650787/management-of-small-unruptured-intracranial-aneurysms-a-survey-of-neuroradiologists
#5
A Malhotra, X Wu, B Geng, D Hersey, D Gandhi, P Sanelli
BACKGROUND AND PURPOSE: The long-term history and management of unruptured intracranial aneurysms is not well understood. Our aim was to determine current practice patterns in the management of unruptured intracranial aneurysms, especially regarding imaging surveillance for conservatively managed aneurysms of this type. MATERIALS AND METHODS: An on-line survey was designed to examine physician practice and preference regarding the management of small unruptured intracranial aneurysms (≤7 mm in diameter)...
April 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29629900/recipient-mucosal-associated-invariant-t-cells-control-gvhd-within-the-colon
#6
Antiopi Varelias, Mark D Bunting, Kate L Ormerod, Motoko Koyama, Stuart D Olver, Jasmin Straube, Rachel D Kuns, Renee J Robb, Andrea S Henden, Leanne Cooper, Nancy Lachner, Kate H Gartlan, Olivier Lantz, Lars Kjer-Nielsen, Jeffrey Yw Mak, David P Fairlie, Andrew D Clouston, James McCluskey, Jamie Rossjohn, Steven W Lane, Philip Hugenholtz, Geoffrey R Hill
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I-like molecule MR1. Here, we demonstrate using MR1 tetramers that recipient MAIT cells are present in small but definable numbers in graft-versus-host disease (GVHD) target organs and protect from acute GVHD in the colon following bone marrow transplantation (BMT). Consistent with their preferential juxtaposition to microbial signals in the colon, recipient MAIT cells generate large amounts of IL-17A, promote gastrointestinal tract integrity, and limit the donor alloantigen presentation that in turn drives donor Th1 and Th17 expansion specifically in the colon after BMT...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29627749/nurses-responses-to-interruptions-during-medication-tasks-a-time-and-motion-study
#7
Clinta Ché Reed, Ann F Minnick, Mary S Dietrich
BACKGROUND: The majority of interruption research has focused on the undesirable effects of interruptions, especially related to errors during medication tasks. However, there may be times when interruptions result in positive effects by providing new information to a situation or preventing an error. The study of nurses' responses to interruptions is limited. Since interruptions cannot (and possibly should not) be avoided, a reasonable method for handling interruptions might be to learn how best to prepare for and manage interruption-prone situations...
March 27, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29625927/tolerance-kinetics-and-depth-of-response-for-subcutaneous-versus-intravenous-administration-of-bortezomib-combination-in-chinese-patients-with-newly-diagnosed-multiple-myeloma
#8
Yan Xu, Shuhui Deng, Xuehan Mao, Gang An, Zengjun Li, Yafei Wang, Mariateresa Fulciniti, Matthew Ho, Jianhong Lin, Weiwei Sui, Wei Liu, Dehui Zou, Shuhua Yi, Wenyang Huang, Hong Liu, Rui Lv, Jian Li, Tingyu Wang, Chenxing Du, Nikhil C Munshi, Lugui Qiu
BACKGROUND: Peripheral neuropathy (PN) is an important toxicity that limits the use of bortezomib (Btz). Attempts to reduce PN have included its subcutaneous (SC) administration. PATIENTS AND METHODS: We retrospectively analyzed 307 patients with newly diagnosed multiple myeloma from a single Chinese center, receiving Btz-based regimens administered either via SC injection (SC group, n = 167) or intravenous (IV) infusion (IV group, n = 140). The efficacy and safety of Btz administration via SC and IV were then compared...
March 15, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29625451/a-robust-optomotor-assay-for-assessing-the-efficacy-of-optogenetic-tools-for-vision-restoration
#9
Qi Lu, Tushar H Ganjawala, Samer Hattar, Gary W Abrams, Zhuo-Hua Pan
Purpose: To develop an animal behavioral assay for the quantitative assessment of the functional efficacy of optogenetic therapies. Methods: A triple-knockout (TKO) mouse line, Gnat1-/-Cnga3-/-Opn4-/-, and a double-knockout mouse line, Gnat1-/-Cnga3-/-, were employed. The expression of channelrhodopsin-2 (ChR2) and its three more light-sensitive mutants, ChR2-L132C, ChR2-L132C/T159C, and ChR2-132C/T159S, in inner retinal neurons was achieved using rAAV2 vectors via intravitreal delivery...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29622872/beneficial-effect-of-low-fixed-dose-of-hydroxyurea-in-vaso-occlusive-crisis-and-transfusion-requirements-in-adult-hbss-patients-a-prospective-study-in-a-tertiary-care-center
#10
Sudha Sethy, Tribikram Panda, Rabindra Kumar Jena
Significant reduction in morbidity and mortality have been documented in patients with sickle cell disease (HbSS) by most of the studies using hydroxyurea at a dose of 25-35 mg/kg/day or maximum tolerated dose. But toxicities, need for frequent monitoring, compliance and cost are important hurdles particularly in Indian set up. We undertook this study to find out the efficacy, safety compliance rate of low fixed dose of hydroxyurea (10 mg/kg/day) in patients presenting to our hospital and its impact on clinical profile and laboratory parameters...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29622831/experience-with-argon-laser-trabeculoplasty-in-nigerians
#11
Olusola Olawoye, Adelina A Ashaye, Tarela F Sarimiye
Aim: To report the safety and efficacy of Argon Laser Trabeculoplasty (ALT) in reducing intraocular pressure (IOP). Settings and Design: This was a retrospective study performed on 25 eyes of 25 patients. Methods and Materials: Consecutive patients who met the inclusion criteria for ALT were recruited from the ophthalmic clinic of the University College Hospital Ibadan, Nigeria and followed up for a minimum period of six months. Two criteria were used to define successful response...
December 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29621877/the-prognostic-role-of-circulating-epstein-barr-virus-dna-copy-number-in-angioimmunoblastic-t-cell-lymphoma-treated-with-dose-adjusted-epoch
#12
Jin-Hua Liang, Luo Lu, Hua-Yuan Zhu, Wang Li, Lei Fan, Jian-Yong Li, Wei Xu
Purpose: Determine the frequency and prognostic value of circulating Epstein-Barr virus (EBV) DNA copy number in angioimmunoblastic T-cell lymphoma (AITL) patients who were treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH) regimens. Materials and Methods: Sixty newly-diagnosed AITL patients were retrospectively enrolled in the present study. All patients were treated with DA-EPOCH regimen. Results: Twenty-two subjects (36...
April 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29620659/individualized-pelvic-lymphadenectomy-should-follow-neoadjuvant-concurrent-chemoradiotherapy-for-locally-advanced-cervical-cancer
#13
Li-Chun Wei, Xin Li, Ying Zhang, Yun-Zhi Dang, Wei-Wei Li, Jian-Ping Li, Li-Na Zhao, Shu-Juan Liu, Xia Li, Mei Shi
To study the outcomes following concurrent chemoradiotherapy (CCRT) and subsequent radical surgery for locally advanced cervical cancer (LACC), analyze the relationship between imaging-diagnosed and postoperative-diagnosed lymph node (LN) involvement, and identify patients who would benefit from individualized pelvic lymphadenectomy.We retrospectively reviewed records of 410 patients who underwent CCRT followed by radical surgery for International Federation of Gynecology and Obstetrics Stage Ib2-IIIb disease...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29620631/pediatric-hyperimmunoglobulin-e-syndrome-a-case-series-of-4-children-in-china
#14
Huifeng Fan, Li Huang, Diyuan Yang, Yunting Lin, Gen Lu, Yaping Xie, Jialu Yu, Dongwei Zhang
Hyperimmunoglobulin E syndromes (HIES) are rare primary immunodeficiency diseases characterized by markedly elevated serum immunoglobulin (Ig) E, recurrent pneumonia, and chronic eczema. To date, information about pediatric HIES is limited. We aimed to evaluate the spectrum of clinical and immunological features in pediatric patients with HIES in China.We retrospectively reviewed the cases of 4 pediatric patients with HIES followed at the Guangzhou Women and Children's Medical Center from May 2013 to September 2017...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619998/association-of-il36rn-mutation-with-clinical-features-therapeutic-response-to-acitretin-and-frequency-of-recurrence-in-patients-with-generalized-pustular-psoriasis
#15
Teng Zhu, Hongzhong Jin, Dan Shu, Feng Li, Chao Wu
Previous studies have revealed that IL36RN mutations play a pivotal role in the pathogenesis of generalized pustular psoriasis (GPP), however, the clinical relevance is unclear. To investigate the correlation between IL36RN mutations and clinical features, recurrence frequency, and therapeutic response to acitretin in GPP patients with long-term follow-up. This retrospective cohort study, lasting 2-4 years, included 61 GPP and 48 psoriasis vulgaris (PV) patients. Sequence analysis of all five exons of the IL36RN gene revealed two genetic variants (c...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29619416/early-and-late-changes-in-natural-killer-cells-in-response-to-ledipasvir-sofosbuvir-treatment
#16
Lucy Golden-Mason, Rachel H McMahan, Michael S Kriss, Alexandra L Kilgore, Linling Cheng, Rachael J Dran, Amanda Wieland, Hugo R Rosen
Chronic hepatitis C virus (HCV) infection is characterized by dysregulated natural killer (NK) cell responses. NKs play a critical role in achieving sustained responses to interferon (IFN)-α-based therapy. Rapid sustained HCV-RNA clearance is now achieved with direct-acting antivirals (DAAs). Studies of patients receiving first-wave DAAs suggest NK functional restoration. Here, we investigate the effect of mainstream DAA treatment on NKs. We collected a prospective cohort of male HCV genotype 1-infected patients treated with ledipasvir/sofosbuvir (n = 22)...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29619111/intratympanic-gentamicin-for-intractable-m%C3%A3-ni%C3%A3-re-s-disease-a-review-and-analysis-of-audiovestibular-impact
#17
Sertaç Yetişer
Introduction  Intratympanic gentamicin regulates the symptoms in most patients with incapacitating Ménière's disease. The treatment protocols have changed over the years from medical labyrinthectomy to preservation of vestibular function. Objectives  This study aims to review the audiovestibular response related to the effect of the drug in controlling vertigo. Data Synthesis  Articles were identified by means of a search in the PubMed database using the key words Meniere and intratympanic or transtympanic gentamicin ...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29616023/immune-control-of-burkholderia-pseudomallei-common-high-frequency-t-cell-responses-to-a-broad-repertoire-of-immunoprevalent-epitopes
#18
Arnone Nithichanon, Darawan Rinchai, Surachat Buddhisa, Pornpun Saenmuang, Chidchamai Kewcharoenwong, Bianca Kessler, Prasong Khaenam, Ploenchan Chetchotisakd, Bernard Maillere, John Robinson, Catherine J Reynolds, Rosemary J Boyton, Daniel M Altmann, Ganjana Lertmemongkolchai
Burkholderia pseudomallei (Bp) is an environmental bacterial pathogen that causes potentially lethal sepsis in susceptible individuals and is considered a Category B, Tier-1 biothreat agent. As such, it is crucial to gain an improved understanding of protective immunity and potential vaccine candidates. The nature of immune correlates dictating why most exposed individuals in endemic regions undergo asymptomatic seroconversion while others succumb to life-threatening sepsis is largely uncharted. Bp seroreactive, immunogenic proteins have previously been identified by antigen microarray...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29615142/impact-of-automatic-milking-systems-on-dairy-cattle-producers-reports-of-milking-labour-management-milk-production-and-milk-quality
#19
C Tse, H W Barkema, T J DeVries, J Rushen, E A Pajor
Automatic milking systems (AMS), or milking robots, are becoming widely accepted as a milking technology that reduces labour and increases milk yield. However, reported amount of labour saved, changes in milk yield, and milk quality when transitioning to AMS vary widely. The purpose of this study was to document the impact of adopting AMS on farms with regards to reported changes in milking labour management, milk production, milk quality, and participation in dairy herd improvement (DHI) programmes. A survey was conducted across Canada over the phone, online, and in-person...
April 4, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29611341/outcome-and-predictors-of-renal-survival-in-patients-with-lupus-nephritis-comparison-between-cyclophosphamide-and-mycophenolate-mofetil
#20
Young Bin Joo, Young Mo Kang, Hyoun-Ah Kim, Chang-Hee Suh, Tae-Jong Kim, Yong-Wook Park, Jisoo Lee, Joo-Hyun Lee, Dae Hyun Yoo, Sang-Cheol Bae, Hye-Soon Lee, So-Young Bang
AIM: To compare renal outcomes between cyclophosphamide (CYC) and mycophenolate mofetil (MMF), and attempt to identify a predictor of renal survival. METHODS: A total of 99 patients with class III-V lupus nephritis (LN) and treated with CYC or MMF were enrolled. The remission rate and predictors of poor renal outcomes in LN were assessed. RESULTS: The mean age at LN diagnosis was 31.7 years. The baseline characteristics of the two groups were similar except for the chronicity index (3...
April 2, 2018: International Journal of Rheumatic Diseases
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