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https://www.readbyqxmd.com/read/29924353/genetic-basis-of-resistance-to-avian-influenza-in-different-commercial-varieties-of-layer-chickens
#1
Wioleta Drobik-Czwarno, Anna Wolc, Janet E Fulton, Tomasz Jankowski, Jesus Arango, Neil P O'Sullivan, Jack C M Dekkers
An outbreak of H5N2 highly pathogenic avian influenza (HPAI) in 2015, resulting in mandatory euthanization of millions of chickens, was one of the most fatal in the US history. The aim of this study was to detect genes associated with survival following natural infection with HPAI during this outbreak. Blood samples were collected from 274 individuals from 3 commercial varieties of White Leghorn. Survivors and age and genetics matched non-affected controls from each variety were included in the comparison. All individuals were genotyped on the 600k SNP array...
June 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29924276/-optimal-cytoreduction-in-advanced-ovarian-cancer-treated-with-dose-dense-paclitaxel-and-carboplatin-followed-by-interval-surgery-at-the-peruvian-national-institute-of-neoplastic-diseases
#2
Cindy Alcarraz, Johana Muñiz, Luis Mas, Mivael Olivera, Zaida Morante, Manuel Alvarez, Raul Mantilla, Jhajaira Araujo, Joseph Pinto
To determine the rate of optimal cytoreduction in patients with advanced ovarian cancer who received neoadjuvant chemotherapy with dose-dense carboplatin and paclitaxel followed by interval debulking surgery (IDS). A retrospective study of a series of cases of Peruvian women treated with neoadjuvant chemotherapy with carboplatin (6 AUC mg/mL/min) and paclitaxel (80 mg/m2 weekly) followed by IDS, at the National Institute of Neoplastic Diseases during the 2010-2014 period. The 41 patients who made it to the interval surgery had a median age of 59 years (range: 47-73 years)...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29923505/optogenetic-entrainment-of-neural-oscillations-with-hybrid-fiber-probes
#3
Antje Kilias, Andres Canales, Ulrich P Froriep, Seongjun Park, Ulrich Egert, Polina Anikeeva
Optogenetic modulation of neural activity is a ubiquitous tool for basic investigation of brain circuits. While the majority of optogenetic paradigms rely on short light pulses to evoke synchronized activity of optically sensitized cells, many neurobiological processes are associated with slow local field potential (LFP) oscillations. Therefore, we developed a hybrid fiber probe capable of simultaneous electrophysiological recording and optical stimulation and used it to investigate the utility of sinusoidal light stimulation for evoking oscillatory neural activity in vivo across a broad frequency range...
June 20, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29922291/transcriptomics-of-the-vaccine-immune-response-priming-with-adjuvant-modulates-recall-innate-responses-after-boosting
#4
Francesco Santoro, Elena Pettini, Dmitri Kazmin, Annalisa Ciabattini, Fabio Fiorino, Gregor D Gilfillan, Ida M Evenroed, Peter Andersen, Gianni Pozzi, Donata Medaglini
Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical importance for the rational design of vaccination strategies. In this study, transcriptomics was employed to profile the effect of the vaccine adjuvant used for priming on the immune response following re-exposure to the vaccine antigen alone. Mice were primed with the chimeric vaccine antigen H56 of Mycobacterium tuberculosis administered alone or with the CAF01 adjuvant and boosted with the antigen alone. mRNA sequencing was performed on blood samples collected 1, 2, and 7 days after priming and after boosting...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29921233/midwives-experience-of-their-education-knowledge-and-practice-around-immersion-in-water-for-labour-or-birth
#5
Lucy Lewis, Yvonne L Hauck, Janice Butt, Chloe Western, Helen Overing, Corrinne Poletti, Jessica Priest, Dawn Hudd, Brooke Thomson
BACKGROUND: There is limited research examining midwives' education, knowledge and practice around immersion in water for labour or birth. Our aim was to address this gap in evidence and build knowledge around this important topic. METHODS: This mixed method study was performed in two phases, between August and December 2016, in the birth centre of a tertiary public maternity hospital in Western Australia. Phase one utilised a cross sectional design to examine perceptions of education, knowledge and practice around immersion in water for labour or birth through a questionnaire...
June 19, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29920440/association-of-the-loudness-dependence-of-auditory-evoked-potentials-with-clinical-changes-to-repetitive-transcranial-magnetic-stimulation-in-patients-with-depression
#6
Sangmin Lee, Kuk-In Jang, Jeong-Ho Chae
BACKGROUND: Although the application of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression has been well investigated, there are few biological predictors of clinical outcomes to rTMS treatment. Previous studies have suggested that the loudness dependence of auditory evoked potentials (LDAEP) can be used as a predictor of response to antidepressant treatment. However, little is known about the association between rTMS and LDAEP. The present study aimed to investigate whether baseline LDAEP is associated with clinical changes to rTMS treatment in patients with major depressive disorder (MDD), and to explore the effect of high-frequency rTMS on LDAEP...
May 19, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29915978/nonlinearization-naturalistic-stimulation-and-nonlinear-dynamic-behavior-in-a-spider-mechanoreceptor
#7
Andrew S French, Keram Pfeiffer
In a previous study, we used linear frequency response analysis to show that naturalistic stimulation of spider primary mechanosensory neurons produced different response dynamics than the commonly used Gaussian random noise. We isolated this difference to the production of action potentials from receptor potential and suggested that the different distribution of frequency components in the naturalistic signal increased the nonlinearity of action potential encoding. Here, we tested the relative contributions of first- and second-order processes to the action potential signal by measuring linear and quadratic coherence functions...
June 18, 2018: Biological Cybernetics
https://www.readbyqxmd.com/read/29915138/oscillatory-encoding-of-visual-stimulus-familiarity
#8
Samuel T Kissinger, Alexandr Pak, Yu Tang, Sotiris C Masmanidis, Alexander A Chubykin
Familiarity of the environment changes the way we perceive and encode incoming information. However, the neural substrates underlying this phenomenon are poorly understood. Here we describe a new form of experience-dependent low frequency oscillations in the primary visual cortex (V1) of awake adult male mice. The oscillations emerged in visually evoked potentials (VEPs) and single-unit activity following repeated visual stimulation. The oscillations were sensitive to the spatial frequency content of a visual stimulus and required the muscarinic acetylcholine receptors (mAChRs) for their induction and expression...
June 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29914763/-characteristics-of-post-traumatic-blindness-at-the-yaound%C3%A3-army-training-application-and-referral-hospital
#9
G Koki, G Helles, Y Bilong, P Biangoup, H Aboubakar, E Epée, A L Bella, C Ebana Mvogo
PURPOSE: To study the characteristics of blindness after ocular trauma. METHODOLOGY: In this retrospective descriptive study, we considered the files of patients who had consulted the service for ocular trauma between January 2008 and December 2014. Included were patients of both sexes and all ages whose monocular or binocular vision with best optical correction was strictly below 1/20. Statistical analysis was performed with EPI Info version 3.5.4 software, and the Chi2  test was used with statistically significant values of P≤0...
June 15, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29913550/phylotyping-based-virulence-associated-genes-and-drug-susceptibility-of-uropathogenic-escherichia-coli-in-urinary-tract-infection-patients
#10
Ahmad Farajzadah Sheikh, Sajad Aslani, Seyed Ahmad Hosseini, Mansour Amin, Hamed Goodarzi, Nabi Jomehzadeh, Reza Ranjbar, Mina Moradzadeh, Samireh Azarpira, Mohammad Moradi, Mohamad Hashemzadeh
Different E.coli phylogenetic groups (A, B1, B2 and D) through possess four functional groups; (I) adhesins , (II) microcins , (III) toxins , and (IV) capsule can be caused urinary tract infections. Special phylogenetic group with high virulence content become a worldwide health concern. Resistance to antimicrobial agents increasingly complicates the management of extraintestinal infections due to E.coli , which are a major source of illness, death, and increased healthcare costs. The aim of this study was to determination of virulence content and antimicrobial susceptibility pattern of different Uropathogenic E...
May 8, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29913411/evaluation-of-coordination-hysteresis-in-a-multidimensional-movement-task-with-continuous-relative-phase-and-self-organizing-maps
#11
Ben Serrien, Naaike Verhaeghe, Silke Verhaeghe, Bruno Tassignon, Jean-Pierre Baeyens
Hysteresis in the coordination of movement can be described in the language of coordination dynamics as an asymmetrical response of a system's order parameter with respect to opposite changes in a control parameter. For movement tasks involving a large number of active degrees-of-freedom, the order parameter can be modelled with a pattern recognition approach like Self-Organizing Maps (SOM). This study explored this method in a rope-skipping task, which involves the coordinated oscillation of several segments in the lower and upper limb and trunk and we compared the results to a classical order parameter like continuous relative phase...
June 15, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29909885/an-assessment-of-patient-burdens-from-head-and-neck-cancer-survivorship-care
#12
Sean T Massa, Rebecca L Rohde, Carole Mckinstry, Malia Gresham, Nosayaba Osazuwa-Peters, Gregory M Ward, Ronald J Walker
OBJECTIVES: To assess head and neck cancer (HNC) patients' perspectives on the value and burdens of routine cancer follow-up care. MATERIALS AND METHODS: Data was obtained from HNC patients (n = 100) at an urban, tertiary head and neck cancer clinic. A novel 15-question survey tool evaluated the logistic, financial, and psychosocial burdens associated with clinic visits. The clinical characteristics and survey responses of demographic groups were analyzed with comparative statistics...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29907628/characteristics-of-patients-with-neovascular-age-related-macular-degeneration-who-are-non-responders-to-intravitreal-aflibercept
#13
Chikako Hara, Taku Wakabayashi, Hiroshi Toyama, Yoko Fukushima, Kaori Sayanagi, Shigeru Sato, Hirokazu Sakaguchi, Kohji Nishida
PURPOSE: To investigate the frequency and patient characteristics that influence anatomic response of intravitreal aflibercept in treatment-naïve neovascular age-related macular degeneration (AMD). DESIGN: Retrospective, interventional, consecutive case series. METHODS: Three hundred and sixty-five eyes of 365 patients with AMD who underwent 3 monthly intravitreal aflibercept treatments with follow-up for at least 12 months were investigated...
June 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29907093/effect-of-administration-of-a-probiotic-preparation-on-gut-microbiota-and-immune-response-in-healthy-women-in-india-an-open-label-single-arm-pilot-study
#14
Ankita Singh, Aditya N Sarangi, Amit Goel, Rajni Srivastava, Rajat Bhargava, Priyanka Gaur, Amita Aggarwal, Rakesh Aggarwal
BACKGROUND: Probiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the host immune responses. However, the available data on the effect of probiotics on these parameters are quite limited. METHODS: We studied the composition of fecal microbiota, using 16S rRNA sequencing, and host immune responses in peripheral blood (plasma cytokine levels, T cell subsets and in vitro cytokine production after stimulation with anti-CD3/CD28 antibody or lipopolysaccharide) in a group of 14 healthy women at three time-points - before and after administration of a probiotic preparation (a capsule of VSL#3, each containing 112...
June 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29907075/analysis-of-research-on-nurses-job-stress-using-network-analysis
#15
Young-Su Kim, Soo-Kyoung Lee
This study established a network related to nurses' job stress by conducting a social network analysis of titles, keywords, and abstracts, and it identified emerging topics of research. NetMiner 4.0 visualized an interconnection between critical keywords and investigated their frequency of appearance to construe the trends in nurses' job stress measures used in studies conducted over 55 years (1960-2015). Text Rank Analyzer examined a collection of 9,218 keywords from 2,662 studies. The analysis revealed four groups of newly emerging keywords in the research...
June 1, 2018: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29906948/higher-order-fluctuation-dissipation-relations-in-plasma-physics-binary-coulomb-systems
#16
Kenneth I Golden
A recent approach that led to compact frequency domain formulations of the cubic and quartic fluctuation-dissipation theorems (FDTs) for the classical one-component plasma (OCP) [Golden and Heath, J. Stat. Phys. 162, 199 (2016)10.1007/s10955-015-1395-6] is generalized to accommodate binary ionic mixtures. Paralleling the procedure followed for the OCP, the basic premise underlying the present approach is that a (k,ω) 4-vector rotational symmetry, known to be a pivotal feature in the frequency domain architectures of the linear and quadratic fluctuation-dissipation relations for a variety of Coulomb plasmas [Golden et al...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29904123/response-inhibition-on-the-stop-signal-task-improves-during-cardiac-contraction
#17
Charlotte L Rae, Vanessa E Botan, Cassandra D Gould van Praag, Aleksandra M Herman, Jasmina A K Nyyssönen, David R Watson, Theodora Duka, Sarah N Garfinkel, Hugo D Critchley
Motor actions can be facilitated or hindered by psychophysiological states of readiness, to guide rapid adaptive action. Cardiovascular arousal is communicated by cardiac signals conveying the timing and strength of individual heartbeats. Here, we tested how these interoceptive signals facilitate control of motor impulsivity. Participants performed a stop signal task, in which stop cues were delivered at different time points within the cardiac cycle: at systole when the heart contracts (T-wave peak, approximately 300 ms following the R-wave), or at diastole between heartbeats (R-wave peak)...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902198/intimal-and-medial-arterial-changes-defined-by-ultra-high-frequency-ultrasound-response-to-changing-risk-factors-in-children-with-chronic-kidney-disease
#18
Frida Dangardt, Marietta Charakida, Scott Chiesa, Devina Bhowruth, Alicja Rapala, Daniela Thurn, Franz Schaefer, John Deanfield, Rukshana Shroff
BACKGROUND: Patients with chronic kidney disease (CKD) are exposed to both traditional 'Framingham' and uremia related cardiovascular risk factors that drive atherosclerotic and arteriosclerotic disease, but these cannot be differentiated using conventional ultrasound. We used ultra-high-frequency ultrasound (UHFUS) to differentiate medial thickness (MT) from intimal thickness (IT) in CKD patients, identify their determinants and monitor their progression. METHODS: Fifty-four children and adolescents with CKD and 12 healthy controls underwent UHFUS measurements using 55-70MHz transducers in common carotid and dorsal pedal arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29901698/association-of-dietary-insulinemic-potential-and-colorectal-cancer-risk-in-men-and-women
#19
Fred K Tabung, Weike Wang, Teresa T Fung, Stephanie A Smith-Warner, NaNa Keum, Kana Wu, Charles S Fuchs, Frank B Hu, Edward L Giovannucci
Background: Insulin response may be important in colorectal cancer development. Diet modulates insulin response and may be a modifiable factor in colorectal cancer prevention. Objective: We examined associations between hyperinsulinemic diets and colorectal cancer risk with the use of an empirical dietary index for hyperinsulinemia (EDIH), a food-based index that characterizes dietary insulinemic potential on the basis of circulating C-peptide concentrations. Design: Diet was assessed every 4 y with food-frequency questionnaires in 46,210 men (Health Professionals Follow-Up Study, 1986-2012) and 74,191 women (Nurses' Health Study, 1984-2012) to calculate EDIH scores...
June 12, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29900890/latent-tuberculosis-infection-among-patients-with-coronary-artery-stenosis-a-case-control-study
#20
Ahmad Farooq Alsayed Hasanain, Khalid M El-Maghraby, Ali A H Zayed, Amany M A Nafee, Sherif M Abdel-Aal, Sally M Bakkar
Background: The activation of the cell-mediated immune responses by Mycobacterium tuberculosis can promote atherogenesis. Aims: The aim of this study is to determine the frequency of latent tuberculosis infection (LTBI) among patients with coronary artery stenosis (CAS) and to explore the association between LTBI and development of CAS. We conducted a case-control study which included 183 patients' who underwent percutaneous coronary angiography (121 patients with CAS and 62 patients without as a control group)...
April 2018: International Journal of Mycobacteriology
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