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https://www.readbyqxmd.com/read/28231250/corticospinal-excitability-measurements-using-transcranial-magnetic-stimulation-are-valid-with-intramuscular-electromyography
#1
Rebekah L S Summers, Mo Chen, Teresa J Kimberley
OBJECTIVES: Muscular targets that are deep or inaccessible to surface electromyography (sEMG) require intrinsic recording using fine-wire electromyography (fEMG). It is unknown if fEMG validly record cortically evoked muscle responses compared to sEMG. The purpose of this investigation was to establish the validity and agreement of fEMG compared to sEMG to quantify typical transcranial magnetic stimulation (TMS) measures pre and post repetitive TMS (rTMS). The hypotheses were that fEMG would demonstrate excellent validity and agreement compared with sEMG...
2017: PloS One
https://www.readbyqxmd.com/read/28230292/age-related-changes-in-pain-sensitivity-in-healthy-humans-a-systematic-review-with-meta-analysis
#2
REVIEW
H El Tumi, M I Johnson, P B F Dantas, M J Maynard, O A Tashani
: Literature suggests that pain perception diminishes in old age. The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal. The aim of this systematic review, with meta-analysis, was to determine age-related changes in pain sensitivity in healthy pain-free adults, children and adolescents. A search of PubMed, Science Direct, and PsycINFO identified studies that compared pain sensitivity response to noxious stimuli at different time points in the lifespan of healthy individuals...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28229892/safety-and-efficacy-of-opicinumab-in-acute-optic-neuritis-renew-a-randomised-placebo-controlled-phase-2-trial
#3
Diego Cadavid, Laura Balcer, Steven Galetta, Orhan Aktas, Tjalf Ziemssen, Ludo Vanopdenbosch, Jette Frederiksen, Mark Skeen, Glenn J Jaffe, Helmut Butzkueven, Focke Ziemssen, Luca Massacesi, Yi Chai, Lei Xu, Stefanie Freeman
BACKGROUND: The human monoclonal antibody opicinumab (BIIB033, anti-LINGO-1) has shown remyelinating activity in preclinical studies. We therefore assessed the safety and tolerability, and efficacy of opicinumab given soon after a first acute optic neuritis episode. METHODS: This randomised, double-blind, placebo-controlled, phase 2 study (RENEW) was done at 33 sites in Australia, Canada, and Europe in participants (aged 18-55 years) with a first unilateral acute optic neuritis episode within 28 days from study baseline...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28229459/differential-serotonergic-modulation-across-the-main-and-accessory-olfactory-bulbs
#4
Zhenbo Huang, Nicolas Thiebaud, Debra Ann Fadool
Mitral cells (MCs) contained in the main (MOB) and accessory (AOB) olfactory bulb have distinct intrinsic membrane properties but a comparison of the extent of neuromodulation across the two systems is not well explored. Herein, we investigated a widely-distributed CNS modulator, serotonin (5-HT), for its ability to modulate the biophysical properties of MCs across the MOB and AOB, using an in vitro, brain slice approach in postnatal 15-30 day mice. In the MOB, 5-HT elicited three types of responses in 93% of 180 cells tested...
February 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28228733/maturation-of-airway-defensive-reflexes-is-related-to-development-of-feeding-behavior-during-growth-in-rabbits
#5
Laurianne Coutier-Marie, Iulia Ioan, Claude Bonabel, Bruno Demoulin, Anne-Laure Leblanc, Ludivine Debitu, Cyril Schweitzer, François Marchal, Silvia Demoulin-Alexikova
Introduction: Cough and expiration reflex are major lower airway defense mechanisms that have not been studied throughout development in relation with the feeding behavior. Aim: To describe airway defense reflexes evoked by mechanical stimulation of the trachea in developing rabbit pups. Material and Methods: Sixty one pups were allocated to 3 groups according to their feeding behavior: suckling (n = 22), weanling (n = 21) and weaning (n = 18) group. The incidence and sensitivity of defense reflexes triggered by mechanical tracheal stimulation were studied in anesthetized and tracheotomized animals...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28227924/a-hybrid-hardware-and-software-approach-for-cancelling-stimulus-artifacts-during-same-electrode-neural-stimulation-and-recording
#6
Stanislav Culaclii, Brian Kim, Yi-Kai Lo, Wentai Liu, Stanislav Culaclii, Brian Kim, Yi-Kai Lo, Wentai Liu, Brian Kim, Yi-Kai Lo, Wentai Liu, Stanislav Culaclii
Recovering neural responses from electrode recordings is fundamental for understanding the dynamics of neural networks. This effort is often obscured by stimulus artifacts in the recordings, which result from stimuli injected into the electrode-tissue interface. Stimulus artifacts, which can be orders of magnitude larger than the neural responses of interest, can mask short-latency evoked responses. Furthermore, simultaneous neural stimulation and recording on the same electrode generates artifacts with larger amplitudes compared to a separate electrode setup, which inevitably overwhelm the amplifier operation and cause unrecoverable neural signal loss...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227899/peripheral-sensory-stimulation-is-neuroprotective-in-a-rat-photothrombotic-ischemic-stroke-model
#7
Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor, Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor, Lun-De Liao, Nitish V Thakor, Frances Lim, Chua Le Teng Sherry, Aishwarya Bandla, Chan Kim Chuan
Ischemic stroke is one of the leading causes of death and disability in the world. Thrombolytic therapy using recombinant tissue plasminogen activator (rtPA), the only FDA-approved drug for acute ischemia, is limited by a narrow therapeutic time window and risk of hemorrhage. There is a serious need for a neuroprotective therapy which is clinically viable. We earlier demonstrated that peripheral sensory stimulation (PSS) is a potential therapeutic intervention for hyperacute ischemia resulting in recovery of neurovascular functions when administered immediately following ischemia onset in a rat model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227847/a-compact-representation-for-the-auditory-full-range-response-and-its-fast-denoising-using-an-image-filter-based-on-the-radon-transform
#8
Manuel C Kohl, Daniel J Strauss, Manuel C Kohl, Daniel J Strauss, Daniel J Strauss, Manuel C Kohl
The Auditory Brainstem, Middle-Latency and Late Responses, a class of event-related potentials (ERPs), are of considerable interest in neuroscience research as robust neural correlates of different processing stages along the auditory pathway. While most research to date centers around one of the responses at a time for practical reasons, recent efforts indicate a paradigm shift towards acquiring them together, enabling the simultaneous monitoring of all auditory processing stages from the brainstem to the cortex...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227802/developing-a-one-channel-bci-system-using-a-dry-claw-like-electrode
#9
Xuhong Guo, Weihua Pei, Yijun Wang, Qiang Gui, He Zhang, Xiao Xing, Yong Huang, Hongda Chen, Ruicong Liu, Yuanyuan Liu, Xuhong Guo, Weihua Pei, Yijun Wang, Qiang Gui, He Zhang, Xiao Xing, Yong Huang, Hongda Chen, Ruicong Liu, Yuanyuan Liu, Hongda Chen, Yijun Wang, Weihua Pei, Yuanyuan Liu, Ruicong Liu, He Zhang, Qiang Gui, Xuhong Guo, Yong Huang, Xiao Xing
An eight-class SSVEP-based BCI system was designed and demonstrated in this study. To minimize the complexity of the traditional equipment and operation, only one work electrode was used. The work electrode was fabricated in our laboratory and designed as a claw-like structure with a diameter of 15 mm, featuring 8 small fingers of 4mm length and 2 mm diameter, and the weight was only 0.1g. The structure and elasticity can help the fingers pass through the hair and contact the scalp when placed on head. The electrode was capable to collect evoked brain activities such as steady-state visual evoked potentials (SSVEPs)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227760/cross-frequency-coupling-during-auditory-perception-in-human-cortex
#10
Urszula Malinowska, Dana Boatman-Reich, Urszula Malinowska, Dana Boatman-Reich, Urszula Malinowska, Dana Boatman-Reich
Cross-frequency coupling plays an important role in coordinating neuronal computations underlying human perception, learning and memory. Here we compared four methods for measuring phase/amplitude coupling (PAC) of theta (4-7 Hz) and high-gamma (70-150 Hz) in intracranial electrocorticographic (ECoG) recordings. Time-frequency spectral and time-domain evoked responses were derived for comparison. All four methods showed significant increases in theta/high-gamma PAC in auditory cortex at sites where significant event-related increases in high-gamma power were also observed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227748/the-correlation-between-transcranial-magnetic-stimulation-parameters-and-neuromuscular-properties-in-children-with-cerebral-palsy
#11
H Marzbani, Sh Parvin, S Amiri, M Lotfian, M R Kharazi, Sh Azizi, M M Mirbagheri, H Marzbani, Sh Parvin, S Amiri, M Lotfian, M R Kharazi, Sh Azizi, M M Mirbagheri, M R Kharazi, Sh Azizi, M Lotfian, M M Mirbagheri, S Amiri, Sh Parvin, H Marzbani
We studied the correlation between corticospinal signaling and neuromuscular properties in children with Cerebral Palsy (CP). Corticospinal signaling was evaluated using Transcranial Magnetic Stimulation (TMS). Neuromuscular properties were quantified using Hoffmann reflex (H-reflex), sonoelastography, clinical measurements, and isokinetic measures. In particular, we determined the relationship between the TMS parameters of the ankle joint and the neuromuscular features of ankle extensors and flexors as well as popular clinical measures of gait speed, endurance, balance and mobility...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227697/simultaneous-evaluation-of-prepulse-inhibition-with-emg-and-eeg-using-advanced-artifact-removal-techniques
#12
Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Paulo R Menezes, Claudemiro V Noya, Rosana Shuhama, Milton A Avila, Cristina M Del-Ben, Cristiane Salum, Rodrigo S Martin, Maria I Zimiani
Prepulse inhibition (PPI) consists of a reduction of the acoustic startle reflex (SR) magnitude (measured with EMG) when a startling stimulus is preceded by a non-startling one. This behavior has been extensively investigated in studies related to schizophrenia, since sensory-motor deficit plays a central role in its pathophysiology. However, the same auditory stimuli that trigger the SR also provoke intense auditory evoked responses (AEP), which can be measured with EEG. Comparing these two types of responses, acquired simultaneously, is a great opportunity to investigate the dependence and interdependence of their neural pathways...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227557/sudden-changes-in-walking-surface-compliance-evoke-contralateral-emg-in-a-hemiparetic-walker-a-case-study-of-inter-leg-coordination-after-neurological-injury
#13
Jeffrey Skidmore, Panagiotis Artemiadis, Jeffrey Skidmore, Panagiotis Artemiadis, Jeffrey Skidmore, Panagiotis Artemiadis
Gait impairment due to neurological disorders is a significant problem around the world. Despite the growing interest in using robotic devices for gait rehabilitation, their widespread use remains limited as there is no clear evidence that robot-assisted gait therapy is superior to traditional treadmill-based therapy. This work is a case study that focuses on investigating the existence of mechanisms of inter-leg coordination after neurological injury, and based on that, proposing novel methods for gait rehabilitation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227552/research-on-eeg-features-of-attended-unattended-vigilance
#14
Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou, Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou, Miao Tian, Minpeng Xu, Hongzhi Qi, Runge Chen, Dong Ming, Chang Sun, Xingwei An, Peng Zhou, Xuemin Wang
Vigilance refers to the brain alertness to objective things, including the concentration of attention and the capability to response emergencies. It is of great importance to study vigilance monitoring to avoid accidents caused by decrease of vigilance. In this study, traditional Mackworth Clock Test (MCT) was modified to induce decline of attended and unattended vigilance. We analyzed EEG features in different levels of attended vigilance and assessed unattended vigilance by amplitude of mismatch negative (MMN) which can be evoked by audio odd ball stimulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227393/an-integrated-neuroprotective-intervention-for-brain-ischemia-validated-by-ecog-fpam
#15
Yu-Hang Liu, Lun-De Liao, Su Jing Chan, Aishwarya Bandla, Nitish V Thakor, Yu-Hang Liu, Lun-De Liao, Su Jing Chan, Aishwarya Bandla, Nitish V Thakor, Yu-Hang Liu, Aishwarya Bandla, Nitish V Thakor, Su Jing Chan, Lun De Liao
Brain ischemia is a neurological deficit caused by a reduction in the blood supply to tissue, and one of the leading causes of disability in the world. Currently, the most well-known therapeutic agent for ischemia recovery is recombinant tissue plasminogen activator (rtPA), but it is viable for only a small portion (approximately 3.6%) of ischemic patients and may cause side effects such as tissue damage. Thus, introducing a new therapeutic concept for ischemia, we proposed an integrated intervention combining global and focal stimulations in this article...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227326/detection-of-binaural-interaction-in-free-field-evoked-auditory-brainstem-responses-by-time-scale-representations
#16
Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Horst Hessel, Erik Schebsdat, Harald Seidler, Daniel J Strauss
The so called β-wave of the binaural interaction component (BIC) in auditory brainstem responses (ABR) has been shown to be an objective measure for binaural interaction (BI). This component is the arithmetical difference between the sum of the monaurally evoked ABRs and the binaurally evoked ABR. Unfortunately, these neural responses are known to be very fragile and as a result the calculated BIC. An additional issue is, that the findings of this measurement are predominantly needed in people with hearing loss who may use hearing devices like hearing aids (HA) or cochlear implants (CI), thus they are not able to use headphones (like in conventional ABR measurements) during the detection of possible BI...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227180/electrical-stimulation-of-the-saphenous-nerve-in-anesthetized-rats-a-novel-therapeutic-approach-to-treating-overactive-bladder
#17
Zainab Moazzam, Paul B Yoo, Zainab Moazzam, Paul B Yoo, Paul B Yoo, Zainab Moazzam
Posterior Tibial Nerve Stimulation (PTNS) is a minimally invasive yet effective therapy for treating overactive bladder (OAB) symptoms with electrical stimulations applied at 20 Hz coupled with amplitudes approximating the foot-twitch threshold (T). However, pre-clinical studies indicate that PTNS-evoked bladder reflexes require stimulation amplitudes exceeding 2T. The objective of this work was to evaluate the presence of secondary low-threshold sensory pathways in the hind-limb region that can be a potential target of activation during clinical PTNS set-up...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227093/applicability-of-ssvep-based-brain-computer-interfaces-for-robot-navigation-in-real-environments
#18
Christina Farmaki, Georgios Christodoulakis, Vangelis Sakkalis, Christina Farmaki, Georgios Christodoulakis, Vangelis Sakkalis, Vangelis Sakkalis, Christina Farmaki, Georgios Christodoulakis
Brain-computer interfaces have been extensively studied and used in order to aid patients suffering from neuromuscular diseases to communicate and control the surrounding environment. Steady-state visual evoked potentials (SSVEP) constitute a very popular BCI stimulation protocol, due to their efficiency and quick response time. In this study, we developed a SSVEP-based BCI along with a low-cost custom radio-controlled robot-car providing live video feedback from a wireless camera mounted on the robot, serving as our testbed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226891/an-implantable-microelectrode-array-for-dopamine-and-electrophysiological-recordings-in-response-to-l-dopa-therapy-for-parkinson-s-disease
#19
Song Zhang, Yilin Song, Jun Jia, Guihua Xiao, Lili Yang, Min Sun, Mixia Wang, Xinxia Cai, Song Zhang, Yilin Song, Jun Jia, Guihua Xiao, Lili Yang, Min Sun, Mixia Wang, Xinxia Cai, Xinxia Cai, Lili Yang, Guihua Xiao, Mixia Wang, Yilin Song, Song Zhang, Min Sun, Jun Jia
Dual-mode multielectrode recordings have become routine in rodent neuroscience research. However, robust and reliable application of acute, multielectrode recording methods in brain especially for in vivo research remains a challenge. In patients with Parkinson's disease (PD), the efficacy of L-dopa therapy depends on its ability to restore Dopamine (DA) neurotransmission in the striatum. In this paper, We describe a low cost thin film 16 sites implantable microelectrode array (MEA) chip fabricated by standard lithography technology for in vivo test...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226826/long-latency-components-of-somatosensory-evoked-potentials-during-passive-tactile-perception-of-gratings
#20
C Genna, F Artoni, C Fanciullacci, C Chisari, C M Oddo, S Micera, C Genna, F Artoni, C Fanciullacci, C Chisari, C M Oddo, S Micera, C M Oddo, F Artoni, S Micera, C Genna, C Fanciullacci, C Chisari
Perception of tactile stimuli elicits Somatosensory Evoked Potentials (SEPs) that can be recorded via non-invasive electroencephalography (EEG). However, it is not yet clear how SEPs localization, shape and latency are modulated by different stimuli during mechanical tactile stimulation of fingertips. The aim of this work is thus to characterize SEPs generated by the tactile perception of gratings during dynamic passive stimulation of the dominant fingertip by means of a mechatronic platform. Results show that a random sequence of stimuli elicited SEPs with two long-latency components: (i) a negative deflection around 140 ms located in the frontal-central-parietal side in the contralateral hemisphere; (ii) a positive deflection around 250 ms located in the frontal-central midline...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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