Koji Inui, Nobuyuki Takeuchi, Bayasgalan Borgil, Megumi Shingaki, Shunsuke Sugiyama, Tomoya Taniguchi, Makoto Nishihara, Takayasu Watanabe, Dai Suzuki, Eishi Motomura, Tetsuo Kida
Responses to a sensory stimulus are inhibited by a preceding stimulus; if the two stimuli are identical, paired-pulse suppression (PPS) occurs; if the preceding stimulus is too weak to reliably elicit the target response, prepulse inhibition (PPI) occurs. PPS and PPI represent excitability changes in neural circuits induced by the first stimulus, but involve different mechanisms and are impaired in different diseases, e.g., impaired PPS in schizophrenia and Alzheimer's disease and impaired PPI in schizophrenia and movement disorders...
2024: Frontiers in Neuroscience