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https://www.readbyqxmd.com/read/28647800/safety-and-effectiveness-of-tolvaptan-for-fluid-management-after-pediatric-cardiovascular-surgery
#1
Yuzo Katayama, Tsukasa Ozawa, Noritsugu Shiono, Hiroshi Masuhara, Takeshiro Fujii, Yoshinori Watanabe
BACKGROUND: Postoperative fluid management is important after open heart surgery, because cardiopulmonary bypass evokes an abnormal inflammatory response and increases vascular permeability, especially in pediatric patients. We assessed the safety and effectiveness of tolvaptan for management of postoperative fluid retention after congenital heart surgery. METHODS AND RESULTS: This retrospective study analyzed data from 43 children with uncomplicated congenital heart disease who underwent open heart surgery between September 2013 and August 2016...
June 24, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28647438/attention-is-allocated-closely-ahead-of-the-target-during-smooth-pursuit-eye-movements-evidence-from-eeg-frequency-tagging
#2
Jing Chen, Matteo Valsecchi, Karl R Gegenfurtner
It is under debate whether attention during smooth pursuit is centered right on the pursuit target or allocated preferentially ahead of it. Attentional deployment was previously probed using a secondary task, which might have altered attention allocation and led to inconsistent findings. We measured frequency-tagged steady-state visual evoked potentials (SSVEP) to measure attention allocation in the absence of any secondary probing task. The observers pursued a moving dot while stimuli flickering at different frequencies were presented at various locations ahead or behind the pursuit target...
June 21, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28646852/the-facial-expression-of-schizophrenic-patients-applied-with-infrared-thermal-facial-image-sequence
#3
Bo-Lin Jian, Chieh-Li Chen, Wen-Lin Chu, Min-Wei Huang
BACKGROUND: Schizophrenia is a neurological disease characterized by alterations to patients' cognitive functions and emotional expressions. Relevant studies often use magnetic resonance imaging (MRI) of the brain to explore structural differences and responsiveness within brain regions. However, as this technique is expensive and commonly induces claustrophobia, it is frequently refused by patients. Thus, this study used non-contact infrared thermal facial images (ITFIs) to analyze facial temperature changes evoked by different emotions in moderately and markedly ill schizophrenia patients...
June 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28645840/autoreject-automated-artifact-rejection-for-meg-and-eeg-data
#4
Mainak Jas, Denis A Engemann, Yousra Bekhti, Federico Raimondo, Alexandre Gramfort
We present an automated algorithm for unified rejection and repair of bad trials in magnetoencephalography (MEG) and electroencephalography (EEG) signals. Our method capitalizes on cross-validation in conjunction with a robust evaluation metric to estimate the optimal peak-to-peak threshold - a quantity commonly used for identifying bad trials in M/EEG. This approach is then extended to a more sophisticated algorithm which estimates this threshold for each sensor yielding trial-wise bad sensors. Depending on the number of bad sensors, the trial is then repaired by interpolation or by excluding it from subsequent analysis...
June 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28645297/interleukin-1-receptor-type-1-is-overexpressed-in-neurons-but-not-in-glial-cells-within-the-rat-superficial-spinal-dorsal-horn-in-complete-freund-adjuvant-induced-inflammatory-pain
#5
Krisztina Holló, László Ducza, Zoltán Hegyi, Klaudia Dócs, Krisztina Hegedűs, Erzsébet Bakk, Ildikó Papp, Gréta Kis, Zoltán Mészár, Zsuzsanna Bardóczi, Miklós Antal
BACKGROUND: All known biological functions of the pro-inflammatory cytokine interleukin-1β (IL-1β) are mediated by type 1 interleukin receptor (IL-1R1). IL-1β-IL-1R1 signaling modulates various neuronal functions including spinal pain processing. Although the role of IL-1β in pain processing is generally accepted, there is a discussion in the literature whether IL-1β exerts its effect on spinal pain processing by activating neuronal or glial IL-1R1. To contribute to this debate, here we investigated the expression and cellular distribution of IL-1R1 in the superficial spinal dorsal horn in control animals and also in inflammatory pain...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28644712/comparative-analysis-of-behavioral-and-transcriptional-variation-underlying-co2-sensory-neuron-function-and-development-in-drosophila
#6
Jia Wern Pan, Joi McLaughlin, Haining Yang, Charles Leo, Paula Rambarat, Sumie Okuwa, Anaïs Monroy-Eklund, Sabrina Clark, Corbin D Jones, Pelin Cayirlioglu Volkan
Carbon dioxide is an important environmental cue for many insects, regulating many behaviors including some that have direct human impacts. To further improve our understanding of how this system varies among closely related insect species, we examined both the behavioral response to CO2 as well as the transcriptional profile of key developmental regulators of CO2 sensory neurons in the olfactory system across the Drosophila genus. We found that CO2 generally evokes repulsive behavior across most of the Drosophilids we examined, but this behavior has been lost or reduced in several lineages...
June 23, 2017: Fly
https://www.readbyqxmd.com/read/28644567/reliability-of-surface-emg-measurements-from-the-suprahyoid-muscle-complex
#7
Mohit Kothari, Peter William Stubbs, Asger Roer Pedersen, Jim Jensen, Jørgen Feldbaek Nielsen
BACKGROUND: Assessment of swallowing musculature using motor evoked potentials (MEPs) can be used to evaluate neural pathways. However, recording of the swallowing musculature is often invasive, uncomfortable and unrealistic in normal clinical practise. OBJECTIVE: To investigate the possibility of using the suprahyoid muscle complex (SMC) using surface electromyography (sEMG) to assess changes to neural pathways by determining the reliability of measurements in healthy participants over days...
June 23, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28644200/electrical-stimulations-of-the-human-insula-their-contribution-to-the-ictal-semiology-of-insular-seizures
#8
Laure Mazzola, François Mauguière, Jean Isnard
INTRODUCTION: Stereotactic stimulations of the insular cortex through intracranial electrodes aim at characterizing the semiology of insular seizures. These stimulations, carried out in the context of Stereo-Electro-Encephalography (SEEG) during presurgical monitoring of epilepsy, reproduce the ictal symptoms observed during the development of insular seizures. METHODS: The authors reviewed the results of insular stimulations performed in 222 patients admitted between 1997 and 2015 for presurgical SEEG exploration of atypical temporal or perisylvian epilepsy...
July 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28643877/cerebral-haemodynamic-response-to-somatosensory-stimulation-in-neonatal-lambs
#9
Shinji Nakamura, David W Walker, Flora Y Wong
The neurovascular coupling response has been defined for the adult brain but in the neonate non-invasive measurement of local cerebral perfusion using NIRS or BOLD fMRI have yielded variable and inconsistent results, including negative responses suggesting decreased perfusion and localised tissue tissue hypoxia. Also, the impact of permissive hypercapnia (Pa CO2  > 50 mmHg) in the management of neonates on cerebrovascular responses to somatosensory input is unknown. Using NIRS to measure changes in cerebral oxy- and deoxy-haemoglobin (ΔoxyHb, ΔdeoxyHb) in 8 anaesthetised newborn lambs, we studied the cerebral haemodynamic functional response to left median nerve stimulation using stimulus trains of 1...
June 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28643715/microstructure-changes-of-occipital-white-matter-are-responsible-for-visual-problems-in-the-3-4-year-old-very-low-birth-weight-children
#10
Anna Lesniak, Izabela Herman-Sucharska, Małgorzata Klimek, Paulina Karcz, Anna Kubatko-Zielińska, Magdalena Nitecka, Grażyna Dutkowska, Bożena Romanowska-Dixon, Przemko Kwinta
PURPOSE: The main aim of the study was to evaluate which factors affect the long-time visual function in preterm children, whether it is prematurity or retinopathy of prematurity or perhaps disturbances in the visual pathway. MATERIALS AND METHODS: Fifty-eight children with mean birth weight 1016 g (range 520-1500 g) were evaluated at mean age 48 months (range 42-54 months). All children underwent magnetic resonance imaging (MRI) studies, visual evoked potentials (VEPs), and the Developmental Test of Visual Perception (DTVP)...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28642679/assessment-of-ipsilateral-efferent-effects-in-human-via-ecochg
#11
Eric Verschooten, Elizabeth A Strickland, Nicolas Verhaert, Philip X Joris
Development of electrophysiological means to assess the medial olivocochlear (MOC) system in humans is important to further our understanding of the function of that system and for the refinement and validation of psychoacoustical and otoacoustic emission methods which are thought to probe the MOC. Based on measurements in anesthetized animals it has been hypothesized that the MOC-reflex (MOCR) can enhance the response to signals in noise, and several lines of evidence support such a role in humans. A difficulty in these studies is the isolation of efferent effects...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28642617/podoplanin-enhances-lung-cancer-cell-growth-in-vivo-by-inducing-platelet-aggregation
#12
Kenichi Miyata, Ai Takemoto, Sakae Okumura, Makoto Nishio, Naoya Fujita
Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor prognosis. However, the contribution of podoplanin to malignant progression has been elusive. Here we demonstrate that in podoplanin-positive LSCC cells, their growth was abrogated by podoplanin knockout in vivo but not in vitro. Conversely, ectopic expression of podoplanin promoted cell growth in vivo and facilitated intratumoral platelet activation...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642613/protecting-visual-short-term-memory-during-maintenance-attentional-modulation-of-target-and-distractor-representations
#13
Marlies E Vissers, Rasa Gulbinaite, Tijl van den Bos, Heleen A Slagter
In the presence of distraction, attentional filtering is a key predictor of efficient information storage in visual short-term memory (VSTM). Yet, the role of attention in distractor filtering, and the extent to which attentional filtering continues to protect information during post-perceptual stages of VSTM, remains largely unknown. In the current study, we investigated the role of spatial attention in distractor filtering during VSTM encoding and maintenance. Participants performed a change detection task with varying distractor load...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642483/masking-of-a-circadian-behavior-in-larval-zebrafish-involves-the-thalamo-habenula-pathway
#14
Qian Lin, Suresh Jesuthasan
Changes in illumination can rapidly influence behavior that is normally controlled by the circadian clock. This effect is termed masking. In mice, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether masking is wavelength-dependent in other vertebrates, nor is it known whether the thalamus is also involved or how it influences masking. Here, we address these questions in zebrafish. We find that diel vertical migration, a circadian behavior in larval zebrafish, is effectively triggered by blue, but not by red light...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642282/kappa-opioid-receptors-mediate-heterosynaptic-suppression-of-hippocampal-inputs-in-the-rat-ventral-striatum
#15
Julie Brooks, Patricio O'Donnell
Kappa opioid receptors (KOR) are highly enriched within the ventral striatum (VS) and are thought to modulate striatal neurotransmission. This includes presynaptic inhibition of local glutamatergic release from excitatory inputs to the VS. However, it is not known which inputs drive this modulation and what impact they have on the local circuit dynamics within the VS. Individual medium spiny neurons (MSNs) within the VS serve as a site of convergence for glutamatergic inputs arising from the prefrontal cortex (PFC) and limbic regions, such as the hippocampus (HP)...
June 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28640440/frequency-dependent-inhibition-of-bladder-function-by-saphenous-nerve-stimulation-in-anesthetized-rats
#16
Zainab Moazzam, Paul B Yoo
AIMS: Percutaneous tibial nerve stimulation (PTNS) is an effective neuromodulation therapy for treating overactive bladder (OAB). The therapeutic effects are achieved by repeatedly applying electrical stimulation through a percutaneous needle electrode that is used to target the tibial nerve (TN). Anatomical studies indicate there can be multiple saphenous nerve (SAFN) branches located near the site of electrical stimulation, and therefore we investigated the possibility of evoking a bladder-inhibitory reflex by electrically activating the SAFN...
June 22, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28639553/can-we-improve-pressure-feedback-methods-in-vestibular-evoked-myogenic-potentials-by-applying-custom-pressures
#17
Ömer Afşin Özmen, Kasım Özlük, Süay Özmen, Oğuz Basut
OBJECTIVE: The aim of the present study was to use constant and customized pressure levels to improve the feedback method of the blood pressure cuff technique in order to decrease intra-subject and inter-subject variability. MATERIALS AND METHODS: The study was conducted in two stages. In the first stage, the relationship between the pressure level generated in the blood pressure cuff and electromyographic response in the sternocleidomastoid (SCM) muscle was investigated...
June 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28639130/vitamin-c-improves-gastroparesis-in-diabetic-rats-effects-on-gastric-contractile-responses-and-oxidative-stress
#18
Luisa Mota Da Silva, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Daniele Maria-Ferreira, Olair Carlos Beltrame, José Eduardo da Silva-Santos, Maria Fernanda de Paula Werner
BACKGROUND: Diabetic gastroparesis is a common complication of diabetes mellitus, which mainly affects women. Previous studies have demonstrated that oxidative stress is involved in its onset and development. AIMS: This study evaluated the role of vitamin C on diabetes-associated gastric dysmotility. METHODS: Female rats with streptozotocin-induced diabetes were treated with vehicle (water, 1 mL/kg, p.o.), vitamin C (300 mg/kg/day, p.o.), or insulin (6 IU/day, s...
June 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28638700/vowel-decoding-from-single-trial-speech-evoked-electrophysiological-responses-a-feature-based-machine-learning-approach
#19
Han G Yi, Zilong Xie, Rachel Reetzke, Alexandros G Dimakis, Bharath Chandrasekaran
INTRODUCTION: Scalp-recorded electrophysiological responses to complex, periodic auditory signals reflect phase-locked activity from neural ensembles within the auditory system. These responses, referred to as frequency-following responses (FFRs), have been widely utilized to index typical and atypical representation of speech signals in the auditory system. One of the major limitations in FFR is the low signal-to-noise ratio at the level of single trials. For this reason, the analysis relies on averaging across thousands of trials...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638453/the-clinical-impact-of-c-met-over-expression-in-advanced-biliary-tract-cancer-btc
#20
Mi Hwa Heo, Hee Kyung Kim, Hansang Lee, Kyoung-Mee Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Seung Tae Kim
Background: c-MET is a proto-oncogene that encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF). Activation of HGF-c-MET signaling involves cell invasiveness and evokes metastasis through direct involvement of tumor angiogenesis. However, the value of c-MET overexpression is still unknown in metastatic biliary tract cancer (BTC). Methods: We analyzed the incidence and clinicopathologic characteristics of c-MET overexpression in advanced BTC. Moreover, we investigated the value of c-MET overexpression in predicting response to gemicitabine plus cisplatin (GC), a first line standard regimen, and as a prognostic marker in metastatic BTC...
2017: Journal of Cancer
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