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https://www.readbyqxmd.com/read/29050285/high-dose-atorvastatin-reduces-the-risk-of-cardiovascular-events-in-patients-with-percutaneous-coronary-intervention
#1
Changqing Lu, Helei Jia, Zhentao Wang
We systematically searched in PubMed, Web of Science, Embase and China National Knowledge Infrastructure from the inception to March 31, 2017, identified relevant trials about efficacy of high-does Atorvastatin for patients with percutaneous coronary intervention. Twelve studies with the number of 2801 patients were included in the meta-analysis. Compared with control group, high-does Atorvastatin significantly reduced the risk of myocardial infarction in patients with percutaneous coronary intervention (Relative risk =0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049231/dose-duration-and-strain-of-bacillus-calmette-guerin-in-the-treatment-of-nonmuscle-invasive-bladder-cancer-meta-analysis-of-randomized-clinical-trials
#2
Yongjun Quan, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Hyung Suk Kim, Ja Hyeon Ku
BACKGROUND: Intravesical bacillus Calmette-Guerin (BCG) instillation is widely used as an adjuvant therapy after transurethral resection of bladder tumor (TURBT) in patients with intermediate- and high-risk nonmuscle invasive bladder cancer (NMIBC). However, the effective dose, duration, and strain of BCG have not yet been clearly determined. We aimed to elucidate the relationship between dose, duration, and strain of BCG and clinical outcomes in NMIBC patients treated with TURBT. METHODS: We conducted a literature search in Embase, Scopus, and PubMed databases for all relevant articles published up to October 2016 in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049195/the-efficacy-of-combined-intra-articular-and-intravenous-tranexamic-acid-for-blood-loss-in-primary-total-knee-arthroplasty-a-meta-analysis
#3
Zhao Wang, Xiaofei Shen
BACKGROUND: This meta-analysis aimed to illustrate the efficacy and safety of combined topical and intravenous (IV) tranexamic acid (TXA) for blood loss control in primary total knee arthroplasty (TKA) patients. METHODS: In April 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google database. Data on patients prepared for TKA surgery in studies that compared combined topical and IV TXA versus placebo, topical, or IV TXA alone were retrieved...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049174/value-of-shear-wave-elastography-in-discriminating-malignant-and-benign-breast-lesions-a-meta-analysis
#4
Yan Xue, Shuxin Yao, Xiaodong Li, Huarong Zhang
The analysis was aimed to evaluate the diagnostic accuracy of shear wave elastography (SWE) for malignant breast lesions through a meta-analysis.Related articles were searched from Pubmed, Embase, and Cochrane library. Overall sensitivity and specificity were analyzed with DerSimonian and Laird random effects model. Area under curve with corresponding 95% confidence interval (were calculated to evaluate the diagnostic accuracy of SWE. Sensitivity and publication bias were assessed as well.A total of 25 articles including 4128 patients and 4546 breast lesions were included in the pooled analysis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048954/the-cumulative-probability-of-arrest-by-age-28-years-in-the-united-states-by-disability-status-race-ethnicity-and-gender
#5
Erin J McCauley
OBJECTIVES: To estimate the cumulative probability (c) of arrest by age 28 years in the United States by disability status, race/ethnicity, and gender. METHODS: I estimated cumulative probabilities through birth cohort life tables with data from the National Longitudinal Survey of Youth, 1997. RESULTS: Estimates demonstrated that those with disabilities have a higher cumulative probability of arrest (c = 42.65) than those without (c = 29...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048180/-meta-analyses-and-p-curves-support-robust-cycle-shifts-in-women-s-mate-preferences-reply-to-wood-and-carden-2014-and-harris-pashler-and-mickes-2014-correction-to-gildersleeve-haselton-and-fales-2014
#6
(no author information available yet)
Reports an error in "Meta-analyses and p-curves support robust cycle shifts in women's mate preferences: Reply to Wood and Carden (2014) and Harris, Pashler, and Mickes (2014)" by Kelly Gildersleeve, Martie G. Haselton and Melissa R. Fales (Psychological Bulletin, 2014[Sep], Vol 140[5], 1272-1280). In the article, all p-curve analyses examining the Context Moderation Hypothesis Prediction mistakenly included the p-value from Little, Jones, Burt, & Perrett (2007) Study 2 for the simple effect of fertility on attraction to facial symmetry in a short-term relationship context (p < ...
November 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/29046770/assessment-of-risk-of-bias-in-quasi-randomized-controlled-trials-and-randomized-controlled-trials-reported-in-the-korean-journal-of-anesthesiology-between-2010-and-2016
#7
REVIEW
Jong Hae Kim, Tae Kyun Kim, Junyong In, Dong Kyu Lee, Sangseok Lee, Hyun Kang
Bias affects the true intervention effect in randomized controlled trials (RCTs), making the results unreliable. We evaluated the risk of bias (ROB) of quasi-RCTs or RCTs reported in the Korean Journal of Anesthesiology (KJA) between 2010 and 2016. Six kinds of bias (selection, performance, detection, attrition, reporting, and other biases) were evaluated by determining low, unclear, or high ROB for eight domains (random sequence generation, allocation concealment, blinding of participants, blinding of personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other bias) according to publication year...
October 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29046599/we-know-the-yin-but-where-is-the-yang-toward-a-balanced-approach-on-common-source-bias-in-public-administration-scholarship
#8
Bert George, Sanjay K Pandey
Surveys have long been a dominant instrument for data collection in public administration. However, it has become widely accepted in the last decade that the usage of a self-reported instrument to measure both the independent and dependent variables results in common source bias (CSB). In turn, CSB is argued to inflate correlations between variables, resulting in biased findings. Subsequently, a narrow blinkered approach on the usage of surveys as single data source has emerged. In this article, we argue that this approach has resulted in an unbalanced perspective on CSB...
June 2017: Rev Public Pers Adm
https://www.readbyqxmd.com/read/29046267/identifying-sentiment-of-hookah-related-posts-on-twitter
#9
Jon-Patrick Allem, Jagannathan Ramanujam, Kristina Lerman, Kar-Hai Chu, Tess Boley Cruz, Jennifer B Unger
BACKGROUND: The increasing popularity of hookah (or waterpipe) use in the United States and elsewhere has consequences for public health because it has similar health risks to that of combustible cigarettes. While hookah use rapidly increases in popularity, social media data (Twitter, Instagram) can be used to capture and describe the social and environmental contexts in which individuals use, perceive, discuss, and are marketed this tobacco product. These data may allow people to organically report on their sentiment toward tobacco products like hookah unprimed by a researcher, without instrument bias, and at low costs...
October 18, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29046234/nonsteroidal-anti-inflammatory-drugs-for-postoperative-pain-control-after-lumbar-spine-surgery-a-meta-analysis-of-randomized-controlled-trials
#10
Zhifeng Zhang, Haihua Xu, Yunhui Zhang, Wei Li, Yanjie Yang, Tian Han, Zhihui Wei, Xue Xu, Jingui Gao
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) play a role in pain relief, especially in postoperative pain caused by inflammation. They have demonstrated significant opioid dose-sparing effects, which help in reducing postoperative effects and opioid side effects. The objective of this meta-analysis was to explore the role of NSAIDs in reducing postoperative pain at different time intervals and provide reference for medication after lumbar spine surgery by a meta-analysis of randomized controlled trials (RCT)...
October 15, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29045987/perspectives-of-family-medicine-clerkship-directors-regarding-forward-feeding-a-cera-study
#11
Lisa D Mims, Alexei O DeCastro, Ann G Kelly
BACKGROUND AND OBJECTIVES: Forward feeding signifies sharing information about learners for purposes of professional and academic advancement, and promotes progression toward a competency-based educational continuum. The aim of this study is to assess reasons for difficulty or failure of the family medicine clerkship and investigate utilization and methods of forward feeding. Reasons behind medical school policies regarding forward feeding are also evaluated. METHODS: Data were collected through the 2013 Council of Academic Family Medicine (CAFM) Educational Research Alliance (CERA) Family Medicine Clerkship Director survey...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#12
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29044897/a-comparison-of-dietary-estimates-from-the-national-aboriginal-and-torres-strait-islander-health-survey-to-food-and-beverage-purchase-data
#13
Emma McMahon, Thomas Wycherley, Kerin O'Dea, Julie Brimblecombe
OBJECTIVE: We compared self-reported dietary intake from the very remote sample of the National Aboriginal and Torres Strait Islander Nutrition and Physical Activity Survey (VR-NATSINPAS; n=1,363) to one year of food and beverage purchases from 20 very remote Indigenous Australian communities (servicing ∼8,500 individuals). METHODS: Differences in food (% energy from food groups) and nutrients were analysed using t-test with unequal variance. RESULTS: Per-capita energy estimates were not significantly different between the surveys (899 MJ/person/day [95% confidence interval -152,1950] p=0...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29043884/guselkumab-for-psoriasis-a-critical-appraisal-of-phase-iii-studies
#14
Zenas Zn Yiu, Richard B Warren
Biologic therapies have raised the frontiers of accepted treatment efficacy for severe psoriasis. Guselkumab is an IgG1 monoclonal antibody that binds to the p19 subunit and inhibits IL-23. In three Phase III randomized, active comparator and placebo controlled trials, guselkumab demonstrated superior efficacy and a comparable safety profile when assessed against adalimumab and ustekinumab. Critical appraisal highlighted uncertainties over risk of bias from missing details in the trial publications that would be overcome with the provision of accompanying trial protocols, as well as the need for a head-to-head trial against an IL-17 inhibitor...
October 18, 2017: Immunotherapy
https://www.readbyqxmd.com/read/29043442/sex-and-gender-matters-a-sex-specific-analysis-of-original-articles-published-in-the-wiener-klinische-wochenschrift-between-2013-and-2015
#15
Éva Rásky, Anja Waxenegger, Sylvia Groth, Erwin Stolz, Michel Schenouda, Andrea Berzlanovich
BACKGROUND: The variables sex and gender are significantly related to health and disease of women and men. Aiming at quality research, biomedical publications need to account for the key variables sex and gender. METHODS: All original articles published in the Wiener klinische Wochenschrift between 2013 and 2015 were extracted into a database. As a result, the 195 published articles were selected for review led by the Sex and Gender Equity in Research Guidelines (SAGER) by the European Association of Science Editors (EASE)...
October 17, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29043354/lipidomic-profiles-of-drosophila-melanogaster-and-cactophilic-fly-species-models-of-human-metabolic-diseases
#16
Daniel Cázarez-García, Mariana Ramírez Loustalot-Laclette, Therese Ann Markow, Robert Winkler
The metabolic syndrome (MetS) is associated with serious diseases and represents an important threat for global public health. The common fruit fly (Drosophila melanogaster) has served as a model organism to study physiological processes of the MetS, because central metabolic pathways are conserved among species, and because the flies are easy to cultivate in a laboratory. In nature, D. melanogaster is a fruit generalist, feeding on diets rich in simple carbohydrates. Other Drosophilids, however, have specialized on distinct resources...
October 18, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29042406/what-data-sources-do-ophthalmologists-trust
#17
William C Stewart, Jeanette A Stewart, Lindsay A Nelson
To survey ophthalmologists regarding sources they trust when incorporating new medical knowledge into their practice. The survey was distributed primarily to US-based ophthalmologists. Questions were derived based on the lead author's research experience from congresses and discussions and from mentions in the medical literature. In total, 77 physicians completed the survey of 1886 sent (4% response rate). Regarding study design, physicians preferred a well-controlled, randomised, double-masked trial (99%) with multicentred investigational site across a wide geographical area (80%)...
October 17, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/29042393/effects-of-polyethylene-glycol-2-l-alone-or-with-ascorbic-acid-compared-with-polyethylene-glycol-4-l-alone-for-bowel-preparation-before-colonoscopy-protocol-for-a-systematic-review-and-network-meta-analysis
#18
Xu Tian, Wei-Qing Chen, Jie-Li Huang, Lan-Ying He, Bang-Lun Liu, Xi Liu, Hang Zhou, Bing-Rong Liu
INTRODUCTION: Colonoscopy has been regarded as a standard method of detecting and removing gastrointestinal lesions early, while adequate bowel preparation is the prerequisite of determining the diagnostic accuracy and treatment safety of this process. Polyethylene glycol (PEG) based bowel preparation regimens remain the first recommendation, but the optimal option is still uncertain. The aim of this systematic review and network meta-analysis of randomised controlled trials (RCTs) is to determine the optimal PEG based bowel preparation regimen before colonoscopy...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29041965/enrichment-allows-identification-of-diverse-rare-elements-in-metagenomic-resistome-virulome-sequencing
#19
Noelle R Noyes, Maggie E Weinroth, Jennifer K Parker, Chris J Dean, Steven M Lakin, Robert A Raymond, Pablo Rovira, Enrique Doster, Zaid Abdo, Jennifer N Martin, Kenneth L Jones, Jaime Ruiz, Christina A Boucher, Keith E Belk, Paul S Morley
BACKGROUND: Shotgun metagenomic sequencing is increasingly utilized as a tool to evaluate ecological-level dynamics of antimicrobial resistance and virulence, in conjunction with microbiome analysis. Interest in use of this method for environmental surveillance of antimicrobial resistance and pathogenic microorganisms is also increasing. In published metagenomic datasets, the total of all resistance- and virulence-related sequences accounts for < 1% of all sequenced DNA, leading to limitations in detection of low-abundance resistome-virulome elements...
October 17, 2017: Microbiome
https://www.readbyqxmd.com/read/29041964/olfactive-stimulation-interventions-for-managing-procedural-pain-in-preterm-and-full-term-neonates-a-systematic-review-protocol
#20
Gwenaëlle De Clifford-Faugère, Andréane Lavallée, Marilyn Aita
BACKGROUND: While hospitalized in the NICU, preterm neonates undergo many painful procedures. This may be the same for full-term neonates when longer hospitalization is required. Untreated and repeated pain has short-term as well as long-term consequences for these neonates. Pharmacological pain management methods have many limitations in their applications for both preterm and full-term neonates. A combination of different non-pharmacological methods is recommended for pain management...
October 17, 2017: Systematic Reviews
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