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https://www.readbyqxmd.com/read/29471493/the-effect-of-pregnancy-on-endometriosis-facts-or-fiction
#1
Brigitte Leeners, Fabia Damaso, Nicole Ochsenbein-Kölble, Cindy Farquhar
BACKGROUND: It is not uncommon for women with endometriosis to be advised that becoming pregnant might be a useful strategy to manage their symptoms and reduce disease progression. Consequently, many women diagnosed with endometriosis and motivated to become pregnant, may also have expectations regarding improvement of symptoms and the disease. However, study results on the effect of pregnancy on endometriosis are controversial and pregnancy in women with endometriosis is not always associated with improved symptoms...
February 15, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29471308/reporting-guidelines-for-oncology-research-helping-to-maximise-the-impact-of-your-research
#2
REVIEW
Angela MacCarthy, Shona Kirtley, Jennifer A de Beyer, Douglas G Altman, Iveta Simera
Many reports of health research omit important information needed to assess their methodological robustness and clinical relevance. Without clear and complete reporting, it is not possible to identify flaws or biases, reproduce successful interventions, or use the findings in systematic reviews or meta-analyses. The EQUATOR Network (http://www.equator-network.org/) promotes responsible reporting and the use of reporting guidelines to improve the accuracy, completeness, and transparency of health research. EQUATOR supports researchers by providing online resources and training...
February 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29470821/is-eq-5d-5l-better-than-eq-5d-3l-a-head-to-head-comparison-of-descriptive-systems-and-value-sets-from-seven-countries
#3
Mathieu F Janssen, Gouke J Bonsel, Nan Luo
OBJECTIVE: This study describes the first empirical head-to-head comparison of EQ-5D-3L (3L) and EQ-5D-5L (5L) value sets for multiple countries. METHODS: A large multinational dataset, including 3L and 5L data for eight patient groups and a student cohort, was used to compare 3L versus 5L value sets for Canada, China, England/UK (5L/3L, respectively), Japan, The Netherlands, South Korea and Spain. We used distributional analyses and two methods exploring discriminatory power: relative efficiency as assessed by the F statistic, and an area under the curve for the receiver-operating characteristics approach...
February 22, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29470234/incidence-of-neuraxial-abnormalities-is-approximately-8-among-patients-with-adolescent-idiopathic-scoliosis-a-meta-analysis
#4
Michael Faloon, Nikhil Sahai, Todd P Pierce, Conor J Dunn, Kumar Sinha, Ki Soo Hwang, Arash Emami
BACKGROUND: Several studies have sought to address the role of routine preoperative MRI in patients with adolescent idiopathic scoliosis (AIS) undergoing deformity correction. Despite similar results regarding the prevalence of neuraxial anomalies detected on MRI, published conclusions conflict and give opposing recommendations. Lack of consensus has led to important variations in use of MRI before spinal surgery for patients with AIS. QUESTIONS/PURPOSES: This systematic review and meta-analysis of studies about patients with AIS evaluated (1) the overall proportion of neuraxial abnormalities; (2) the patient factors and curve characteristics that may be associated with abnormalities; and (3) the proportion of patients who underwent neurosurgical intervention before scoliosis surgery and the kinds of neuraxial lesions that were identified...
February 21, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29467952/diffusion-weighted-imaging-in-identifying-breast-cancer-pathological-response-to-neoadjuvant-chemotherapy-a-meta-analysis
#5
Wei Chu, Weiwei Jin, Daihong Liu, Jian Wang, Chengjun Geng, Lihua Chen, Xuequan Huang
Background: Diffusion-weighted imaging (DWI) is increasingly used to identify pathological complete responses (pCRs) to neoadjuvant chemotherapy (NAC) in breast cancer. The aim of the present study was to assess the utility of DWI using a pooled analysis. Materials and Methods: Literature databases were searched prior to July 2017. Fifteen studies with a total of 1181 patients were included. The data were extracted to perform pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis and subgroup analyses...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29466868/finding-the-optimal-treatment-model-a-systematic-review-of-treatment-for-co-occurring-alcohol-misuse-and-depression
#6
Breanne Hobden, Jamie Bryant, Mariko Carey, Amanda L Baker, Michael Farrell, Christopher Oldmeadow, Richard P Mattick, Anthony Shakeshaft, Rob Sanson-Fisher
OBJECTIVES: Alcohol misuse and depression are commonly co-occurring conditions. To date, no review has examined the most efficacious treatment model for psychosocial treatment of co-occurring alcohol misuse and depression. This systematic review determined the: (i) methodological quality of publications examining psychosocial treatment of co-occurring alcohol misuse and depression using a sequential, parallel or integrated treatment model; and (ii) effectiveness of each dual treatment model compared to single treatment for those with co-occurring alcohol misuse and depression...
February 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29465747/antibiotics-for-treating-gonorrhoea-in-pregnancy
#7
REVIEW
Gabriella Comunián-Carrasco, Guiomar E Peña-Martí, Arturo J Martí-Carvajal
BACKGROUND: Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review on antibiotics for treating this infectious condition...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29465713/hydrochlorothiazide-and-alternative-diuretics-versus-renin-angiotensin-system-inhibitors-for-the-regression-of-left-ventricular-hypertrophy-a-head-to-head-meta-analysis
#8
George C Roush, Ramy Abdelfattah, Steven Song, John B Kostis, Michael E Ernst, Domenic A Sica
BACKGROUND: Found in 36-41% of hypertension, elevated left ventricular mass (LVM) independently predicts cardiovascular events and total mortality. Conversely, drug-induced regression of LVM predicts improved outcomes. Previous studies have favored renin-angiotensin system inhibitors (RASIs) over other antihypertensives for reducing LVM but ignored differences among thiazide-type diuretics. From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that 'CHIP' diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)] would rival RASIs for reducing LVM...
February 20, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29465324/may-the-power-be-with-you-are-there-highly-powered-studies-in-neuroscience-and-how-can-we-get-more-of-them
#9
Johannes Algermissen, David Marc Anton Mehler
Statistical power is essential for robust science and replicability, but a meta-analysis by Button et al. in 2013 diagnosed a "power failure" for neuroscience. In contrast, Nord et al. (J Neurosci 37: 8051-8061, 2017) re-analyzed these data and suggested that some studies feature high power. We illustrate how publication and researcher bias might have inflated power estimates, and review recently introduced techniques that can improve analysis pipelines and increase power in neuroscience studies.
February 21, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29464401/pathological-outcomes-of-transanal-versus-laparoscopic-total-mesorectal-excision-for-rectal-cancer-a-systematic-review-with-meta-analysis
#10
REVIEW
Hong-Peng Jiang, Yan-Sen Li, Bo Wang, Chang Wang, Fan Liu, Zhan-Long Shen, Ying-Jiang Ye, Shan Wang
BACKGROUND: Since 2010, comparative studies on transanal and laparoscopic total mesorectal excision (TME) have been published and it remains unclear about the oncological benefit from transanal total mesorectal excision (taTME). METHODS: We have searched English databases to identify all taTME studies published between January 2010 and August 2017. Pathological outcomes included circumferential resection margin (CRM), positive CRM (< 1 M), length of distal resection margin (DRM), positive DRM, quality of mesorectum (complete mesorectum), harvested lymph node, and length of the specimen...
February 20, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29464093/impact-of-lmp7-rs2071543-gene-polymorphism-in-increasing-cancer-risk-evidence-from-a-meta-analysis-and-trial-sequential-analysis
#11
Raju K Mandal, Sajad A Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, Bhartendu N Mishra, Naseem Akhter, Mohammed Y Areeshi, Shafiul Haque
Genetic variant LMP7 (low molecular weight polypeptide 7) -145 C > A may influence the function of immune surveillance of an individual and lead to cancer development. Various studies have investigated the relevance of LMP7 -145 C > A gene polymorphism with cancer risk; but, their results are conflicting and inconsistent. To obtain a comprehensive conclusion, a meta-analysis was performed by including eight eligible published studies retrieved from PubMed (Medline), EMBASE and Google Scholar web search until December 2016...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29462765/incidence-of-haematological-malignancies-eastern-cape-province-south-africa-2004-2013
#12
Diana Oelofse, Ilse Truter
BACKGROUND: The incidence of haematological malignancies in Africa's rapidly urbanising populations is insufficiently explored. Reliable population-based cancer statistics, however, continues to be a scarce resource in Africa and tends to be urban biased with limited rural coverage. In addition, many haematological malignancies are regarded as rare cancers, a sub-group that often affects the young disproportionately and require advanced diagnostic services and facilities able to deliver costly sophisticated treatments...
February 17, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29462592/platelet-lymphocyte-ratio-acts-as-an-independent-predictor-of-prognosis-in-patients-with-renal-cell-carcinoma
#13
Zhun Wang, Shuanghe Peng, Aixiang Wang, Hui Xie, Linpei Guo, Ning Jiang, Yuanjie Niu
BACKGROUND: The prognostic value of plated-lymphocyte ratio (PLR) in multiple malignancies had been investigated in previous studies; however, its prognostic value in renal cell carcinoma (RCC) remains controversial. This study was performed to assess the prognostic value of preoperative PLR in RCC patients. METHODS: Literature was searched from PubMed, Embase, Web of Science and Cochrane database, which evaluated the relationships between preoperative PLR and prognosis in RCC patients...
February 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29462155/rifampicin-versus-streptomycin-for-brucellosis-treatment-in-humans-a-meta-analysis-of-randomized-controlled-trials
#14
Fanjie Meng, Xiangpo Pan, Wenzhen Tong
Brucellosis is a zoonotic disease with a high morbidity in developing countries, but there the optimal treatment is not yet determined. Therefore, the development of a simple and effective treatment is important. The aim of this study was to summarize the available evidences and compare rifampicin with streptomycin in human brucellosis with doxycycline as background regimen. We systematically searched PubMed, EmBase, and the Cochrane Library from their inception up through December 2016. We included studies with a randomized controlled design that evaluated the effect of streptomycin compared with rifampicin in human brucellosis patients who received doxycycline therapy as background regimen...
2018: PloS One
https://www.readbyqxmd.com/read/29458778/anti-hypertensive-drugs-and-skin-cancer-risk-a-review-of-the-literature-and-meta-analysis
#15
REVIEW
Sara Gandini, Domenico Palli, Giuseppe Spadola, Benedetta Bendinelli, Emilia Cocorocchio, Ignazio Stanganelli, Lucia Miligi, Giovanna Masala, Saverio Caini
INTRODUCTION: Several anti-hypertensive drugs have photosensitizing properties, however it remains unclear whether long-term users of these drugs are also at increased risk of skin malignancies. We conducted a literature review and meta-analysis on the association between use of anti-hypertensive drugs and the risk of cutaneous melanoma and non-melanoma skin cancer (NMSC). METHODS: We searched PubMed, EMBASE, Google Scholar and the Cochrane Library, and included observational and experimental epidemiological studies published until February 28th, 2017...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29458744/alcohol-and-the-risk-of-sleep-apnoea-a-systematic-review-and-meta-analysis
#16
Evangelia Simou, John Britton, Jo Leonardi-Bee
OBJECTIVE: A systematic review and meta-analysis of the association between alcohol consumption and risk of sleep apnoea in adults. METHODS: We searched Medline, EMBASE and Web of Science databases from 1985 to 2015 for comparative epidemiological studies assessing the relation between alcohol consumption and sleep apnoea. Two authors independently screened and extracted data. Random effects meta-analysis was used to estimate pooled effect sizes with 95% confidence intervals (CI)...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29458317/statistical-analysis-plan-for-the-augmented-versus-routine-approach-to-giving-energy-trial-target
#17
(no author information available yet)
BACKGROUND: The Augmented versus Routine Approach to Giving Energy Trial (TARGET) is a 4000-patient randomised, double-blind controlled trial designed to evaluate whether enteral delivery of recommended energy goals using a 1.5 kcal/mL enteral nutrition formulation improves clinical outcomes, compared with a 1 kcal/mL enteral nutrition formulation delivered at the same goal rate, in critically ill patients receiving invasive mechanical ventilation. OBJECTIVE: In keeping with best practice, and in accordance with other trials conducted by the investigators, a pre-specified statistical analysis plan has been described and made public before completion of patient recruitment and data collection into the TARGET trial...
March 2018: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/29458154/the-effect-of-endoscopic-surveillance-in-patients-with-barrett-s-esophagus-a-systematic-review-and-meta-analysis
#18
Don Chamil Codipilly, Apoorva Krishna Chandar, Siddharth Singh, Sachin Wani, Nicholas J Shaheen, John M Inadomi, Amitabh Chak, Prasad G Iyer
BACKGROUND & AIMS: Guidelines recommend endoscopic surveillance of patients with Barrett's esophagus (BE) to identify those with dysplasia (a precursor of carcinoma) or early-stage esophageal adenocarcinoma (EAC), who can be treated endoscopically. However, it is unclear whether surveillance increases survival times of patients with BE. We performed a systematic review and meta-analysis to qualitatively and quantitatively examine evidence for the association of endoscopic surveillance in patients with BE with survival and other outcomes...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29455749/does-social-insurance-enrollment-improve-citizen-assessment-of-local-government-performance-evidence-from-china
#19
Xian Huang, Qin Gao
Although many studies claim that social policies are "carrots" that authoritarian leaders use to garner public support, the assumption that social benefits can boost public support of government has been rarely tested empirically, especially at the local levels. This article investigates the effects of social insurance enrollment on citizens' assessment of local government performance using data from the 2010 China Family Panel Study. We use propensity score matching to reduce selection bias and ordered probit regressions with fixed effects to examine these possible effects...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29455695/the-empirical-support-for-mindfulness-based-interventions-for-common-psychiatric-disorders-a-systematic-review-and-meta-analysis
#20
Maria Hedman-Lagerlöf, Erik Hedman-Lagerlöf, Lars-Göran Öst
Mindfulness-based interventions (MBIs) have become widely used for common mental disorders (CMDs) but the state of the evidence has not been sufficiently investigated. The aims for this study were: (1) to quantify the effect size of MBIs for CMDs in the acute phase; (2) to explore moderator variables; and (3) to evaluate the evidence status of MBIs for the CMDs it has been tried for. A comprehensive systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted. RCTs that evaluated MBI and included patients with a primary manifest CMD was included...
February 19, 2018: Psychological Medicine
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