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https://www.readbyqxmd.com/read/29243456/robotic-versus-laparoscopic-sleeve-gastrectomy-a-review-of-the-current-evidence
#1
Vasiliki S Tasiopoulou, Alexis A Svokos, Konstantina A Svokos, Dimitrios Zacharoulis, Dimitrios E Magouliotis
INTRODUCTION: The purpose of the present study was to review the existing evidence on obese patients treated with either robotic or laparoscopic sleeve gastrectomy, in order to compare the clinical and perioperative outcomes of the two methods. EVIDENCE ACQUISITION: A systematic literature search was performed in PubMed, Cochrane library and Scopus databases. EVIDENCE SYNTHESIS: Sixteen studies were included in the present review and incorporated 29,787 patients...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29241213/antibiotics-induced-obesity-a-mitochondrial-perspective
#2
Melisa J Andrade, Chinchu Jayaprakash, Smitha Bhat, Nikolaos Evangelatos, Angela Brand, Kapaettu Satyamoorthy
Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity...
December 15, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29238916/impact-of-bariatric-surgical-intervention-on-peripheral-blood-neutrophil-pbn-function-in-obesity
#3
Helen M Roberts, Melissa M Grant, Naomi Hubber, Paul Super, Rishi Singhal, Iain L C Chapple
AIM: The aim of this study was to investigate the impact of weight loss following gastric band surgery on multiple measures of peripheral blood neutrophil (PBN) function. MATERIAL AND METHODS: Twenty-three obese patients undergoing gastric band surgery were recruited to a longitudinal intervention study, alongside non-obese, healthy gender- and age-matched controls. Eighteen pairs of patients and controls completed all stages of the study. PBNs were isolated by density centrifugation and a comprehensive analysis of PBN function was undertaken at various stages of the patients' bariatric surgical care pathway...
December 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29238576/a-case-of-legionella-pneumonia-caused-by-home-use-of-continuous-positive-airway-pressure
#4
Ruby Schnirman, Nasifa Nur, Alice Bonitati, Gerardo Carino
A 67-year-old woman with morbid obesity and severe obstructive sleep apnea presented to the emergency department with 2 days of productive cough, fever, shortness of breath and loose stools. A chest x-ray showed extensive bilateral infiltrates, and she was quickly intubated for acute hypoxic respiratory failure. A urine legionella antigen test was positive, and she was admitted to the intensive care unit with a diagnosis of severe legionella pneumonia. She improved over the next week with a course of levofloxacin...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29238123/epidemiology-triggers-and-severity-of-childhood-asthma-in-ilesa-nigeria-implications-for-management-and-control
#5
Bankole Peter Kuti, Kehinde Oluyori Omole
Background: Knowledge about childhood asthma in a locality will assist clinicians to adequately manage the condition. This study set out to report the epidemiology, triggers of exacerbation, comorbid conditions, and severity of childhood asthma at a tertiary health facility in Nigeria and the implication of these, in management and symptoms control. Methods: Over a 15-month study period, children (aged <15 years) with physician-diagnosed asthma were consecutively recruited at the pediatric chest clinic of the hospital...
January 2017: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/29234200/nutrition-and-muscle-in-cirrhosis
#6
REVIEW
Anil C Anand
As the cirrhosis progresses, development of complication like ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma signify increasing risk of short term mortality. Malnutrition and muscle wasting (sarcopenia) is yet other complications that negatively impact survival, quality of life, and response to stressors, such as infection and surgery in patients with cirrhosis. Conventionally, these are not routinely looked for, because nutritional assessment can be a difficult especially if there is associated fluid retention and/or obesity...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29227579/obesity-type-2-diabetes-increases-inflammation-periosteal-reactive-bone-formation-and-osteolysis-during-staphylococcus-aureus-implant-associated-bone-infection
#7
Christopher W Farnsworth, Eric M Schott, Abigail M Benvie, Jacob Zukoski, Stephen L Kates, Edward M Schwarz, Steven R Gill, Michael J Zuscik, Robert A Mooney
Obese and type 2 diabetic (T2D) patients have a 5-fold increased rate of infection following placement of an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation and osteolysis, the effect of obesity/T2D on these complicating factors has not been studied. To address this question, C57BL/6J mice were fed a high fat diet (60% Kcal from fat) to induce obesity/T2D, or a control diet (10% Kcal from fat) for three months, and challenged with a transtibial pin coated with a bioluminescent USA300 strain of S...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29226121/facts-and-fallacies-in-the-debate-on-glyphosate-toxicity
#8
Robin Mesnage, Michael N Antoniou
The safety profile of the herbicide glyphosate and its commercial formulations is controversial. Reviews have been published by individuals who are consultants and employees of companies commercializing glyphosate-based herbicides in support of glyphosate's reapproval by regulatory agencies. These authors conclude that glyphosate is safe at levels below regulatory permissible limits. In contrast, reviews conducted by academic scientists independent of industry report toxic effects below regulatory limits, as well as shortcomings of the current regulatory evaluation of risks associated with glyphosate exposures...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29219814/cellulitis-current-insights-into-pathophysiology-and-clinical-management
#9
D R Cranendonk, A P M Lavrijsen, J M Prins, W J Wiersinga
Cellulitis is a bacterial skin and soft tissue infection which occurs when the physical skin barrier, the immune system and/or the circulatory system are impaired. Diabetes, obesity and old age are associated with defects in all of these areas and as a result are major predisposing factors for cellulitis. In this review, we summarise current insights into the pathophysiology of cellulitis and place the Dutch guidelines on the clinical management of cellulitis of the lower extremities in perspective. Recent evidence on diagnostic strategies is discussed, the importance of which is underscored by findings that venous insufficiency, eczema, deep vein thrombosis and gout are frequently mistaken for cellulitis...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29218687/decline-in-allogeneic-blood-transfusion-usage-in-total-hip-arthroplasty-patients-national-inpatient-sample-2009-to-2013
#10
Chukwuweike U Gwam, Jaydev B Mistry, Jennifer I Etcheson, Nicole E George, Grayson P Connors, Melbin Thomas, Hephzibah Adamu, Nirav G Patel, Ronald E Delanois
INTRODUCTION: Although total hip arthroplasty (THA) is an effective treatment for end-stage arthritis, it is also associated with substantial blood loss that may require allogeneic blood transfusion. However, these transfusions may increase the risk of certain complications. The purpose of our study is to evaluate: (i) the incidence/trends of allogeneic blood transfusion; (ii) the associated risk factors and adverse events; and (iii) the discharge disposition, length of stay (LOS), and costs for these patients between 2009 and 2013...
December 6, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29217381/adiponectin-levels-and-insulin-resistance-among-patients-with-chronic-hepatitis-c
#11
Raoni Freitas Carvalho, Ajax Mercês Atta, Isabela Silva de Oliveira, Taciana Pereira Sant'Ana Santos, João Pedro A Santos, Maria Isabel Schinoni, Maria Luiza Brito de Sousa-Atta
Chronic hepatitis C virus (HCV) infection is associated with insulin resistance (IR), rapid disease progression, and decreased virological response to antiviral treatment. In addition, obesity is a risk factor for chronic hepatitis C evolution and is associated with IR. As adiponectin is an adipokine that is associated with obesity and IR, this study aimed to investigate serum levels of adiponectin among patients with HCV infection and IR. Thirty-three patients with untreated HCV infection underwent testing of serum adiponectin levels (capture ELISA) and were compared to 30 healthy subjects with similar body mass indexes (BMI)...
December 4, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29214070/percutaneous-tracheostomy-a-comprehensive-review
#12
REVIEW
Ashraf O Rashid, Shaheen Islam
Tracheostomy is a common procedure. It can be done surgically or percutaneously by dilating the stoma using Seldinger technique. Percutaneous tracheostomy (PT) is now routinely performed by surgeons and non-surgeons such as intensivists and anesthesiologists in the intensive care units (ICU) all over the world. Although obesity, emergent tracheostomy, coagulopathy, inability to extend the neck and high ventilator demand (HVD) were initially thought to be a relative contraindication, recent data suggest safety of PT in these patient population...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29205415/systematic-review-human-gut-dysbiosis-induced-by-non-antibiotic-prescription-medications
#13
REVIEW
Q Le Bastard, G A Al-Ghalith, M Grégoire, G Chapelet, F Javaudin, E Dailly, E Batard, D Knights, E Montassier
BACKGROUND: Global prescription drug use has been increasing continuously for decades. The gut microbiome, a key contributor to health status, can be altered by prescription drug use, as antibiotics have been repeatedly described to have both short-term and long-standing effects on the intestinal microbiome. AIM: To summarise current findings on non-antibiotic prescription-induced gut microbiome changes, focusing on the most frequently prescribed therapeutic drug categories...
December 5, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29198562/disease-burden-and-costs-from-excess-alcohol-consumption-obesity-and-viral-hepatitis-fourth-report-of-the-lancet-standing-commission-on-liver-disease-in-the-uk
#14
REVIEW
Roger Williams, Graeme Alexander, Iain Armstrong, Alastair Baker, Neeraj Bhala, Ginny Camps-Walsh, Matthew E Cramp, Simon de Lusignan, Natalie Day, Anil Dhawan, John Dillon, Colin Drummond, Jessica Dyson, Graham Foster, Ian Gilmore, Mark Hudson, Deirdre Kelly, Andrew Langford, Neil McDougall, Petra Meier, Kieran Moriarty, Philip Newsome, John O'Grady, Rachel Pryke, Liz Rolfe, Peter Rice, Harry Rutter, Nick Sheron, Alison Taylor, Jeremy Thompson, Douglas Thorburn, Julia Verne, John Wass, Andrew Yeoman
This report contains new and follow-up metric data relating to the eight main recommendations of the Lancet Standing Commission on Liver Disease in the UK, which aim to reduce the unacceptable harmful consequences of excess alcohol consumption, obesity, and viral hepatitis. For alcohol, we provide data on alcohol dependence, damage to families, and the documented increase in alcohol consumption since removal of the above-inflation alcohol duty escalator. Alcoholic liver disease will shortly overtake ischaemic heart disease with regard to years of working life lost...
November 28, 2017: Lancet
https://www.readbyqxmd.com/read/29197664/emerging-metabolic-risk-factors-in-hepatocellular-carcinoma-and-their-influence-on-the-liver-microenvironment
#15
REVIEW
Pasquale Agosti, Carlo Sabbà, Antonio Mazzocca
Despite the reducing incidence of chronic hepatitis infections, an unexpected increasing incidence of hepatocellular carcinoma (HCC) has being occurred. This may be explained by the increasing number of HCCs developing on steatosis (NAFLD) and steatohepatitis (NASH), related to metabolic risk factors (i.e. diabetes mellitus type II, obesity, metabolic syndrome), which are becoming emerging risk factors for HCC. This led to a growing scientific interest on the oncogenic mechanisms underlying the transition from NAFLD to HCC...
November 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29196987/underweight-status-at-diagnosis-is-associated-with-poorer-outcomes-in-adult-patients-with-acute-myeloid-leukemia-a-retrospective-study-of-jalsg-aml-201
#16
Kaito Harada, Noriko Doki, Takeshi Hagino, Shuichi Miyawaki, Shigeki Ohtake, Hitoshi Kiyoi, Yasushi Miyazaki, Hiroyuki Fujita, Noriko Usui, Hirokazu Okumura, Koichi Miyamura, Chiaki Nakaseko, Atsushi Fujieda, Tadashi Nagai, Takahisa Yamane, Hisashi Sakamaki, Kazunori Ohnishi, Tomoki Naoe, Ryuzo Ohno, Kazuteru Ohashi
Recent studies have described various impacts of obesity and being overweight on acute myeloid leukemia (AML) outcomes in adult patients, but little is known about the impact of being underweight. We compared the outcomes of underweight patients to those of normal weight and overweight patients. Adult patients with AML who registered in the JALSG AML201 study (n = 1057) were classified into three groups: underweight (body mass index [BMI] < 18.5, n = 92), normal weight (BMI 18.5-25, n = 746), and overweight (BMI ≥ 25, n = 219)...
December 2, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29193653/incidence-and-risk-factors-for-deep-surgical-site-infection-after-open-reduction-and-internal-fixation-of-closed-tibial-plateau-fractures-in-adults
#17
Qiang Ma, Abulaiti Aierxiding, Guosheng Wang, Chengwei Wang, Lijuan Yu, Zhimin Shen
This study aimed to investigate the incidence and risk factors of deep surgical site infection (DSSI) during hospitalisation after closed tibial plateau fractures treated with open reduction and internal fixation (ORIF). We performed this retrospective study at a university-affiliated hospital with an advanced trauma centre. The data of adult patients with closed tibial plateau fractures treated with ORIF from January 2012 to February 2017 were extracted from the electronic medical records. Demographics, injury-related and surgery-related variables of DSSI and non-DSSI groups were compared by univariate test...
November 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29190573/common-comorbidities-and-survival-in-ms-risk-for-stroke-type-1-diabetes-and-infections
#18
A Murtonen, S Kurki, K Hänninen, M Soilu-Hänninen, M-L Sumelahti
BACKGROUND: Survival in MS has increased during the era of disease modifying therapies, but life expectancy in MS patients is still reduced by several years. Increased risk for common comorbidities related to brain health, such as risk for circulatory diseases have been reported in MS and could affect survival. In this paper, we studied age- and gender adjusted risks for circulatory diseases and related disorders, and their impact on overall MS survival in population of Southwest Finland...
November 13, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29189864/-the-potential-contribution-of-adenovirus-36-to-the-development-of-obesity
#19
Francisca Villavicencio, Macarena Valladares
The evidence of the last 20 years shows a link between viral infections and obesity in animals and humans. There are five adenovirus which have been associated with development of obesity in animals. SMAM-1 virus was the first studied in humans associated with obesity. There is compelling evidence that Ad-36 virus could contribute to the development of obesity in humans and it is related with body mass index (BMI). This manuscript reviews the association between Ad-36 and the other four virus infections with obesity...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29188845/molecular-targets-and-mechanisms-of-bioactive-peptides-against-metabolic-syndromes
#20
REVIEW
Shanshan Li, Ling Liu, Guoqing He, Jianping Wu
Bioactive peptides are present in all living organisms and have critical roles ranging from protection against infection as the key element of innate immunity, regulating blood pressure and glucose levels, to reducing signs of ageing by killing senescent cells. Bioactive peptides are also encrypted within food protein sequences that can be released during proteolysis or food processing. These specific food protein fragments are reported to have potential for improving human health and preventing metabolic diseases through their impact on inflammation, blood pressure, obesity, and type-2 diabetes...
November 30, 2017: Food & Function
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