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https://www.readbyqxmd.com/read/29331534/perinatal-palliative-care-integration-in-a-united-states-nurse-midwifery-education-program
#1
Jenna A LoGiudice, Eileen O'Shea
Midwifery students with perinatal palliative care education develop a skillset to provide holistic midwifery care to women and families who are experiencing stillbirth or life-limiting fetal diagnoses. This paper presents a model of perinatal palliative care in a United States midwifery education program. By utilizing evidence based practices and national programs, perinatal palliative care can be threaded through midwifery curricula to achieve international standards of practice and competencies. Most importantly, enhancing perinatal palliative care education will better prepare future midwives for when a birth outcome is not what was expected at the outset of a pregnancy...
December 28, 2017: Midwifery
https://www.readbyqxmd.com/read/29324697/association-between-fetal-adipokines-and-child-behavioral-problems-at-preschool-age-the-hokkaido-study-on-environment-and-children-s-health
#2
Machiko Minatoya, Sachiko Itoh, Atsuko Araki, Naomi Tamura, Keiko Yamazaki, Chihiro Miyashita, Reiko Kishi
Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age...
January 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29321064/the-role-of-ace2-angiotensin-1-7-and-mas1-receptor-axis-in-glucocorticoid-induced-intrauterine-growth-restriction
#3
Elham Ghadhanfar, Aseel Alsalem, Shaimaa Al-Kandari, Jumana Naser, Fawzi Babiker, Maie Al-Bader
BACKGROUND: Plasma and urine levels of the potent vasodilator Ang-(1-7) are elevated in mid and late pregnancy and are correlated with elevated placental angiogenesis, fetal blood flow, and rapid fetal growth. We hypothesized that Ang-(1-7), its receptor (Mas1) and the enzymes involved in Ang-(1-7) production (ACE2 and Membrane metallo-endopeptidase; MME) are down regulated in response to glucocorticoid administration contributing to IUGR. METHODS: Pregnant female Sprague-Dawley rats were injected with dexamethasone (DEX; 0...
December 29, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29317010/a-new-model-for-fetal-programming-maternal-ramadan-type-fasting-programs-nephrogenesis
#4
M Mohany, N Ashton, A H Harrath, J R Nyengaard, S Y Alomar, S Alwasel
The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined during fetal life, at birth, and in early and late adulthood. Maternal body weight, food intake, relative food intake and plasma glucose levels were significantly lower (P<0.001) in the RTF group...
January 10, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29316601/bariatric-surgery-and-infertility-a-prospective-study
#5
Vincenzo Consalvo, Antonio Canero, Vincenzo Salsano
BACKGROUND: Obesity is a worldwide disease affecting 13% of the world's adult female population. The reasons and the fetal risk are still unclear. The effect of weight loss as a result of bariatric surgery seems to induce an improvement in fertility in obese women. The main purpose of this prospective study is to demonstrate if there is an association between bariatric surgery-induced weight loss and an improvement in the fertility of women at reproductive age. MATERIALS AND METHODS: From June 2013 to April 2016, all bariatric female patients from our institutes were prospectively evaluated for suitability in this study...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29312622/acute-nutritional-stress-during-pregnancy-affects-placental-efficiency-fetal-growth-and-adult-glucose-homeostasis
#6
Sajida Malik, Alan Diot, Karl Morten, Eszter Dombi, Manu Vatish, C A Richard Boyd, Joanna Poulton
Exposure to maternal malnutrition impairs postnatal health. Acute nutritional stress is less clearly implicated in intrauterine programming. We studied the effects of stressing pregnant mothers on perinatal growth and adult glucose homeostasis. We compared one group ("stressed", mothers fasted for 16 hours) with controls ("unstressed"). We found that fasting stress had adverse effects on the weight of the fetuses conceived (p<0.005) and the placental efficiency (p<0.001) in stressed compared to unstressed offspring...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310088/prenatal-exposure-to-perfluoroalkyl-and-polyfluoroalkyl-substances-affects-leukocyte-telomere-length-in-female-newborns
#7
Han Liu, Qian Chen, Lei Lei, Wei Zhou, Lisu Huang, Jun Zhang, Dan Chen
Evidence has shown that leukocyte telomere length (LTL) at birth is related to the susceptibility to various diseases in later life and the setting of newborn LTL is influenced by the intrauterine environment. Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as a kind of persistent organic pollutants, are commonly used in commercial and domestic applications and are capable of crossing the maternal-fetal barrier during pregnancy. We hypothesized that intrauterine exposure to PFASs may affect fetal LTL by increasing oxidative stress...
January 5, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29306096/embryotoxic-cytokines-potential-roles-in-embryo-loss-and-fetal-programming
#8
REVIEW
Sarah A Robertson, Peck-Yin Chin, Joseph G Femia, Hannah M Brown
Cytokines in the reproductive tract environment at conception mediate a dialogue between the embryo and maternal tissues to profoundly influence embryo development and implantation success. Through effects on gene expression and the cell stress response, cytokines elicit an epigenetic impact with consequences for placental development and fetal growth, which in turn affect metabolic phenotype and long-term health of offspring. There is substantial evidence demonstrating that pro-survival cytokines, such as GM-CSF, CSF1, LIF, HB-EGF and IGFII, support embryos to develop optimally...
December 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29304784/ethical-aspects-of-diagnosis-and-interventions-for-children-with-fetal-alcohol-spectrum-disorder-fasd-and-their-families
#9
Gert Helgesson, Göran Bertilsson, Helena Domeij, Gunilla Fahlström, Emelie Heintz, Anders Hjern, Christina Nehlin Gordh, Viviann Nordin, Jenny Rangmar, Ann-Margret Rydell, Viveka Sundelin Wahlsten, Monica Hultcrantz
BACKGROUND: Fetal alcohol spectrum disorders (FASD) is an umbrella term covering several conditions for which alcohol consumption during pregnancy is taken to play a causal role. The benefit of individuals being identified with a condition within FASD remains controversial. The objective of the present study was to identify ethical aspects and consequences of diagnostics, interventions, and family support in relation to FASD. METHODS: Ethical aspects relating to diagnostics, interventions, and family support regarding FASD were compiled and discussed, drawing on a series of discussions with experts in the field, published literature, and medical ethicists...
January 5, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29302701/structure-and-function-of-the-nppa-nppb-cluster-locus-during-heart-development-and-disease
#10
REVIEW
Joyce Man, Phil Barnett, Vincent M Christoffels
Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex and is not well understood...
January 4, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29302150/the-forgotten-plague-psychiatric-manifestations-of-ebola-zika-and-emerging-infectious-diseases
#11
REVIEW
Veronica Tucci, Nidal Moukaddam, Jonathan Meadows, Suhal Shah, Sagar C Galwankar, G Bobby Kapur
The media and public health generally focus on the biological and physical ramifications of epidemics. Mental health issues that coincide with emerging diseases and epidemics are rarely examined and sometimes, even eschewed due to cultural considerations. Psychiatric manifestations of various infectious diseases, especially with a focus on Ebola Virus disease (EVD) and Zika Virus, are discussed in this commentary to illustrate the continued need of care after the resolution of the actual illness. Various infectious diseases have associations with mental illness, such as an increased risk of obsessive-compulsive disorders and Tourette syndrome in children with Group B streptococcal infection...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29301665/parental-rheumatoid-arthritis-and-autism-spectrum-disorders-in-offspring-a-danish-nationwide-cohort%C3%A2-study
#12
Ane Lilleøre Rom, Chun Sen Wu, Jørn Olsen, Damini Jawaheer, Merete Lund Hetland, Lina Steinrud Mørch
OBJECTIVE: Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming. METHOD: The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723)...
January 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29288642/improving-staff-communication-and-transitions-of-care-between-obstetric-triage-and-labor-and-delivery
#13
Kathleen O'Rourke, Joseph Teel, Erika Nicholls, Daniel D Lee, Alyssa Covelli Colwill, Sindhu K Srinivas
OBJECTIVE: To improve staff perception of the quality of the patient admission process from obstetric triage to the labor and delivery unit through standardization. DESIGN: Preassessment and postassessment online surveys. SETTING: A 13-bed labor and delivery unit in a quaternary care, Magnet Recognition Program, academic medical center in Pennsylvania. PARTICIPANTS: Preintervention (n = 100), postintervention (n = 52), and 6-month follow-up survey respondents (n = 75) represented secretaries, registered nurses, surgical technicians, certified nurse-midwives, nurse practitioners, maternal-fetal medicine fellows, anesthesiologists, and obstetric and family medicine attending and resident physicians from triage and labor and delivery units...
December 27, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29283404/key-clinical-factors-predicting-adipokine-and-oxidative-stress-marker-concentrations-among-normal-overweight-and-obese-pregnant-women-using-artificial-neural-networks
#14
Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Otilia Perichart-Perera, Araceli Montoya-Estrada, Mario Guzmán-Huerta, Héctor Borboa-Olivares, Eyerahi Bravo-Flores, Arturo Cardona-Pérez, Veronica Zaga-Clavellina, Ethel Garcia-Latorre, Gabriela Gonzalez-Perez, José Alfredo Hernández-Pérez, Claudine Irles
Maternal obesity has been related to adverse neonatal outcomes and fetal programming. Oxidative stress and adipokines are potential biomarkers in such pregnancies; thus, the measurement of these molecules has been considered critical. Therefore, we developed artificial neural network (ANN) models based on maternal weight status and clinical data to predict reliable maternal blood concentrations of these biomarkers at the end of pregnancy. Adipokines (adiponectin, leptin, and resistin), and DNA, lipid and protein oxidative markers (8-oxo-2'-deoxyguanosine, malondialdehyde and carbonylated proteins, respectively) were assessed in blood of normal weight, overweight and obese women in the third trimester of pregnancy...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29283403/preliminary-findings-that-a-targeted-intervention-leads-to-altered-brain-function-in-children-with-fetal-alcohol-spectrum-disorder
#15
Kelly Nash, Sara Stevens, Hayyah Clairman, Joanne Rovet
Children with fetal alcohol spectrum disorder (FASD) exhibit behavioral dysregulation, executive dysfunction, and atypical function in associated brain regions. Previous research shows early intervention mitigates these outcomes but corresponding brain changes were not studied. Given the Alert® Program for Self-Regulation improves behavioral regulation and executive function in children with FASD, we asked if this therapy also improves their neural functioning in associated regions. Twenty-one children with FASD aged 8-12 years were randomized to the Alert®-treatment (TXT; n = 10) or waitlist-control (WL; n = 11) conditions...
December 28, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29282253/maturation-of-hematopoietic-stem-cells-from-prehematopoietic-stem-cells-is-accompanied-by-up-regulation-of-pd-l1
#16
Joanna Tober, Marijke M W Maijenburg, Yan Li, Long Gao, Brandon K Hadland, Peng Gao, Kodai Minoura, Irwin D Bernstein, Kai Tan, Nancy A Speck
Hematopoietic stem cells (HSCs) mature from pre-HSCs that originate in the major arteries of the embryo. To identify HSCs from in vitro sources, it will be necessary to refine markers of HSCs matured ex vivo. We purified and compared the transcriptomes of pre-HSCs, HSCs matured ex vivo, and fetal liver HSCs. We found that HSC maturation in vivo or ex vivo is accompanied by the down-regulation of genes involved in embryonic development and vasculogenesis, and up-regulation of genes involved in hematopoietic organ development, lymphoid development, and immune responses...
December 27, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29277911/role-of-fetal-nutrient-restriction-and-postnatal-catch-up-growth-on-structural-and-mechanical-alterations-of-rat-aorta
#17
Perla Y Gutiérrez-Arzapalo, Pilar Rodríguez-Rodríguez, David Ramiro-Cortijo, Ángel L López de Pablo, María Rosario López-Giménez, Luis Condezo-Hoyos, Stephen E Greenwald, Maria Del Carmen González, Silvia M Arribas
Fetal undernutrition programs hypertension development, males being more susceptible. Deficient fetal elastogenesis and vascular growth is a possible mechanism. We investigated the role of aortic mechanical alterations in a rat model of hypertension programming, evaluating changes at birth, weaning and adulthood. Dams were fed ad-libitum (Control) or 50% of control intake during the second half of gestation (maternal undernutrition, MUN). 3-day, 21-day and 6-month old offspring were studied. Blood pressure was evaluated in vivo...
December 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29274715/no-133-prevention-of-rh-alloimmunization
#18
Karen Fung Kee Fung, Erica Eason
OBJECTIVE: To provide guidelines on use of anti-D prophylaxis to optimize prevention of rhesus (Rh) alloimmunization in Canadian women. OUTCOMES: Decreased incidence of Rh alloimmunization and minimized practice variation with regards to immunoprophylaxis strategies. EVIDENCE: The Cochrane Library and MEDLINE were searched for English-language articles from 1968 to 200 I, relating to the prevention of Rh alloimmunization. Search terms included: Rho(D) immune globulin, Rh iso- or aile-immunization, anti-D, anti-Rh, WinRho, Rhogam, and pregnancy...
January 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29273781/altered-gene-expression-and-metabolism-in-fetal-umbilical-cord-mesenchymal-stem-cells-correspond-with-differences-in-5-month-old-infant-adiposity-gain
#19
Peter R Baker, Zachary W Patinkin, Allison L B Shapiro, Becky A de la Houssaye, Rachel C Janssen, Lauren A Vanderlinden, Dana Dabelea, Jacob E Friedman
The intrauterine period is a critical time wherein developmental exposure can influence risk for chronic disease including childhood obesity. Using umbilical cord-derived mesenchymal stem cells (uMSC) from offspring born to normal-weight and obese mothers, we tested the hypothesis that changes in infant body composition over the first 5 months of life correspond with differences in cellular metabolism and transcriptomic profiles at birth. Higher long-chain acylcarnitine concentrations, lipid transport gene expression, and indicators of oxidative stress in uMSC-adipocytes were related to higher adiposity at 5 months of age...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29273044/a-randomized-controlled-trial-of-exercise-during-pregnancy-on-maternal-and-neonatal-outcomes-results-from-the-pamela-study
#20
Shana Ginar da Silva, Pedro Curi Hallal, Marlos Rodrigues Domingues, Andréa Dâmaso Bertoldi, Mariângela Freitas da Silveira, Diego Bassani, Inácio Crochemore Mohnsam da Silva, Bruna Gonçalves Cordeiro da Silva, Carolina de Vargas Nunes Coll, Kelly Evenson
BACKGROUND: Women are encouraged to be physically active during pregnancy. Despite available evidence supporting antenatal physical activity to bring health benefits for both the mother and child, the most effective way to prevent some maternal and fetal outcomes is still unclear. The purpose of this study was to evaluate the efficacy of an exercise intervention to prevent negative maternal and newborn health outcomes. METHODS: A randomized controlled trial (RCT) nested into the 2015 Pelotas (Brazil) Birth Cohort Study was carried-out with 639 healthy pregnant women, 213 in the intervention group (IG) and 426 in the control (CG) group...
December 22, 2017: International Journal of Behavioral Nutrition and Physical Activity
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