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Fetal programming

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https://www.readbyqxmd.com/read/28911168/developmental-programming-impact-of-gestational-steroid-and-metabolic-milieus-on-mediators-of-insulin-sensitivity-in-prenatal-testosterone-treated-female-sheep
#1
Muraly Puttabyatappa, Victoria Andriessen, Makeda Mesquitta, Lixia Zeng, Subramaniam Pennathur, Vasantha Padmanabhan
Prenatal testosterone (T) excess in sheep leads to peripheral insulin resistance (IR), reduced adipocyte size, and tissue-specific changes, with liver and muscle but not adipose tissue being insulin resistant. To determine the basis for the tissue-specific differences in insulin sensitivity, we assessed changes in negative (inflammation, oxidative stress, and lipotoxicity) and positive mediators (adiponectin and antioxidants) of insulin sensitivity in the liver, muscle, and adipose tissues of control and prenatal T-treated sheep...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28911139/preeclampsia-downregulates-micrornas-in-fetal-endothelial-cells-roles-of-mir-29a-c-3p-in-endothelial-function
#2
Chi Zhou, Qing-Yun Zou, Hua Li, Rui-Fang Wang, Ai-Xia Liu, Ronald R Magness, Jing Zheng
Context: Preeclampsia is a leading cause of fetal and maternal morbidity and mortality during pregnancy. Although the etiology of preeclampsia is unknown, preeclampsia offspring have increased risks of developing cardiovascular disorders in adulthood, implicating that preeclampsia programs fetal vasculature in utero. Objective: We hypothesize that preeclampsia alters expression profiles of endothelial microRNAs (miRNAs) in fetal endothelial cells and disturbs the vascular endothelial growth factor A (VEGFA)- and fibroblast growth factor 2 (FGF2)-induced endothelial function...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28904115/new-option-in-the-lives-saved-tool-list-allows-for-the-conversion-of-prevalence-of-small-for-gestational-age-and-preterm-births-to-prevalence-of-low-birth-weight
#3
REVIEW
Naoko Kozuki, Joanne Katz, Adrienne Clermont, Neff Walker
Background: The Lives Saved Tool (LiST) is a software model that estimates the health impact of scaling up interventions on maternal and child health. One of the outputs of the model is an estimation of births by fetal size [appropriate-for-gestational-age (AGA) or small-for-gestational-age (SGA)] and by length of gestation (term or preterm), both of which influence birth weight. LiST uses prevalence estimates of births in these categories rather than of birth weight categories, because the causes and health consequences differ between SGA and preterm birth...
September 13, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28903312/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#4
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Onzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-Sampedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903026/differential-expression-of-genes-in-fetal-brain-as-a-consequence-of-maternal-protein-deficiency-and-nematode-infection
#5
Manjurul Haque, Lisa M Starr, Kristine G Koski, Marilyn E Scott
Maternal dietary protein deficiency and gastrointestinal (GI) nematode infection during early pregnancy have negative impacts on both maternal placental gene expression and fetal growth in the mouse. Here we used next-generation RNA sequencing (RNA-Seq) to test our hypothesis that maternal protein deficiency and/or nematode infection also alter the expression of genes in the developing fetal brain. Outbred pregnant CD1 mice were used in a 2x2 design with two levels of dietary protein (24% versus 6%) and two levels of infection (repeated sham versus Heligmosomoides bakeri beginning at gestation day 5)...
September 10, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28901864/prenatal-stress-enhances-susceptibility-to-allergic-diseases-of-offspring
#6
Maria Moustaki, Sophia Tsabouri, Kostas Priftis, Konstantinos Douros
BACKGROUND AND OBJECTIVES: Maternal prenatal stress (MPS) may result in a range of long-term consequences in the offspring among which is susceptibility to allergic diseases. This review presents the current knowledge on the pathways through which MPS may affect the fetus, and the existing evidence regarding the association between MPS and development of allergy in the offspring. RESULT AND DISCUSSION: A pivotal mediator triggered in response to stress is the release of glucocorticoids (GC)...
September 12, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28898573/alternatives-to-autopsy-for-fetal-and-early-neonatal-perinatal-deaths-insights-from-the-wisconsin-stillbirth-service-program
#7
Elspeth McPherson, Eirini Nestoridi, Dominique Heinke, Drucilla J Roberts, Ruth Fretts, Mahsa M Yazdy, Angela E Lin
BACKGROUND: Although autopsy is a key component of the etiologic evaluation following fetal and early neonatal death, and traditionally has been the preferred method to determine the cause of death, an alternative may be suitable when traditional autopsy by a perinatal pathologist is not available or declined. METHODS: Among 3137 cases evaluated through the Wisconsin Stillbirth Service Program (WiSSP), a community-based program for etiologic evaluation of second trimester miscarriage, stillbirth, and early neonatal death, most diagnoses are based on multiple types of data including placental pathology, clinical examination, photographs, maternal records, radiographs, and laboratory testing...
September 12, 2017: Birth defects research
https://www.readbyqxmd.com/read/28895534/molecular-conservation-of-marsupial-and-eutherian-placentation-and-lactation
#8
Michael W Guernsey, Edward B Chuong, Guillaume Cornelis, Marilyn B Renfree, Julie C Baker
Eutherians are often mistakenly termed 'placental mammals', but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is reminiscent of eutherian placentation, including both fetal and maternal signals...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28890543/the-altered-pd-1-pd-l1-pathway-delivers-the-one-two-punch-effects-to-promote-the-treg-th17-imbalance-in-pre-eclampsia
#9
Yonghong Zhang, Zhaozhao Liu, Mei Tian, Xiaohui Hu, Liling Wang, Jinlu Ji, Aihua Liao
The programmed cell death-1 (PD-1)/PD-ligand 1 (PD-L1) pathway is critical for normal pregnancy by promoting regulatory T (Treg) cell development and inhibiting the Th17 response. However, the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia (PE) is an enigma. In this study, decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE. The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation, differentiation and transdifferentiation...
September 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28888992/associations-between-biological-markers-of-prenatal-stress-and-infant-negative-emotionality-are-specific-to-sex
#10
Elizabeth C Braithwaite, Susannah E Murphy, Paul G Ramchandani, Jonathan Hill
PURPOSE: Fetal programming is the idea that environmental stimuli can alter the development of the fetus, which may have a long-term effect on the child. We have recently reported that maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner: high prenatal cortisol was associated with increased negative emotionality in females, and decreased negative emotionality in males. This study aims to test for this sex-specific effect in a different cohort, and investigate whether sex differences in fetal programming may be specific to glucocorticoid mechanisms by also examining a maternal salivary alpha-amylase (sAA) by sex interaction...
September 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28888333/maternal-long-chain-polyunsaturated-fatty-acid-status-and-pregnancy-complications
#11
REVIEW
Nisha Wadhwani, Vidya Patil, Sadhana Joshi
Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders...
August 15, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28887130/gender-specific-impairment-of-in-vitro-sinoatrial-node-chronotropic-responses-and-of-myocardial-ischemia-tolerance-in-rats-exposed-prenatally-to-betamethasone
#12
L R A Kiguti, C S Borges, A Mueller, K P Silva, C M Polo, J L Rosa, P V Silva, G Missassi, L Valencise, W G Kempinas, A S Pupo
Excessive fetal glucocorticoid exposure has been linked to increased susceptibility to hypertension and cardiac diseases in the adult life, a process called fetal programming. The cardiac contribution to the hypertensive phenotype of glucocorticoid-programmed progeny is less known, therefore, we investigated in vitro cardiac functional parameters from rats exposed in utero to betamethasone. Pregnant Wistar rats received vehicle (VEH) or betamethasone (BET, 0.1mg/kg, i.m.) at gestational days 12, 13, 18 and 19...
September 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28886070/microrna-mir-301a-is-a-novel-cardiac-regulator-of-cofilin-2
#13
Ashraf Yusuf Rangrez, Phillip Hoppe, Christian Kuhn, Elisa Zille, Johanne Frank, Norbert Frey, Derk Frank
Calsarcin-1 deficient mice develop dilated cardiomyopathy (DCM) phenotype in pure C57BL/6 genetic background (Cs1-ko) despite severe contractile dysfunction and robust activation of fetal gene program. Here we performed a microRNA microarray to identify the molecular causes of this cardiac phenotype that revealed the dysregulation of several microRNAs including miR-301a, which was highly downregulated in Cs1-ko mice compared to the wild-type littermates. Cofilin-2 (Cfl2) was identified as one of the potential targets of miR-301a using prediction databases, which we validated by luciferase assay and mutation of predicted binding sites...
2017: PloS One
https://www.readbyqxmd.com/read/28878260/%C3%AE-7-nicotinic-acetylcholine-receptor-signaling-modulates-the-inflammatory-phenotype-of-fetal-brain-microglia-first-evidence-of-interference-by-iron-homeostasis
#14
M Cortes, M Cao, H L Liu, C S Moore, L D Durosier, P Burns, G Fecteau, A Desrochers, L B Barreiro, J P Antel, M G Frasch
Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylcholine receptor (α7nAChR) in fetal microglia will augment their neuroprotective transcriptome profile, while the antagonistic stimulation of α7nAChR will achieve the opposite. Using an in vivo - in vitro model of developmental programming of neuroinflammation induced by lipopolysaccharide (LPS), we validated this hypothesis in primary fetal sheep microglia cultures re-exposed to LPS in presence of a selective α7nAChR agonist or antagonist...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871576/first-trimester-combined-screening-for-preeclampsia-and-small-for-gestational-age-a-single-centre-experience-and-validation-of-the-fmf-screening-algorithm
#15
Beatrice Mosimann, Chantal Pfiffner, Sofia Amylidi-Mohr, Lorenz Risch, Daniel Surbek, Luigi Raio
AIM OF THE STUDY: Preeclampsia (PE) is associated with severe maternal and fetal morbidity in the acute presentation and there is increasing evidence that it is also an important risk factor for cardiovascular disease later in life. Therefore, preventive strategies are of utmost importance. The Fetal Medicine Foundation (FMF) London recently developed a first trimester screening algorithm for placenta-related pregnancy complications, in particular early onset preeclampsia (eoPE) requiring delivery before 34 weeks, and preterm small for gestational age (pSGA), with a birth weight <5th percentile and delivery before 37 weeks of gestation, based on maternal history and characteristics, and biochemical and biophysical parameters...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28861346/identification-of-rare-paired-box-3-variant-in-strabismus-by-whole-exome-sequencing
#16
Hui-Min Gong, Jing Wang, Jing Xu, Zhan-Yu Zhou, Jing-Wen Li, Shu-Fang Chen
AIM: To identify the potentially pathogenic gene variants that contributes to the etiology of strabismus. METHODS: A Chinese pedigree with strabismus was collected and the exomes of two affected individuals were sequenced using the next-generation sequencing technology. The resulting variants from exome sequencing were filtered by subsequent bioinformatics methods and the candidate mutation was verified as heterozygous in the affected proposita and her mother by sanger sequencing...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28861041/programmed-fetal-membrane-senescence-and-exosome-mediated-signaling-a-mechanism-associated-with-timing-of-human-parturition
#17
REVIEW
Ramkumar Menon, Sam Mesiano, Robert N Taylor
Human parturition is an inflammatory process that involves both fetal and maternal compartments. The precise immune cell interactions have not been well delineated in human uterine tissues during parturition, but insights into human labor initiation have been informed by studies in animal models. Unfortunately, the timing of parturition relative to fetal maturation varies among viviparous species-indicative of different phylogenetic clocks and alarms-but what is clear is that important common pathways must converge to control the birth process...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28859764/no-347-obstetric-management-at-borderline-viability
#18
Noor Niyar N Ladhani, Radha S Chari, Michael S Dunn, Griffith Jones, Prakesh Shah, Jon F R Barrett
OBJECTIVE: The primary objective of this guideline was to develop consensus statements to guide clinical practice and recommendations for obstetric management of a pregnancy at borderline viability, currently defined as prior to 25+6 weeks. INTENDED USERS: Clinicians involved in the obstetric management of women whose fetus is at the borderline of viability. TARGET POPULATION: Women presenting for possible birth at borderline viability. EVIDENCE: This document presents a summary of the literature and a general consensus on the management of pregnancies at borderline viability, including maternal transfer and consultation, administration of antenatal corticosteroids and magnesium sulfate, fetal heart rate monitoring, and considerations in mode of delivery...
September 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28854715/systematic-review-and-meta-analysis-of-the-impact-of-preconception-lifestyle-interventions-on-fertility-obstetric-fetal-anthropometric-and-metabolic-outcomes-in-men-and-women
#19
L Lan, C L Harrison, M Misso, B Hill, H J Teede, B W Mol, L J Moran
STUDY QUESTION: What is the impact of preconception lifestyle interventions on live birth, birth weight and pregnancy rate? SUMMARY ANSWER: Lifestyle interventions showed benefits for weight loss and increased natural pregnancy rate, but not for live birth or birth weight. WHAT IS KNOWN ALREADY: Evidence on the practice and content of preconception counseling and interventions is variable and limited. STUDY DESIGN, SIZE, DURATION: Systematic review and meta-analysis (MA)...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28853925/sex-determination-in-the-mammalian-germline
#20
Cassy Spiller, Peter Koopman, Josephine Bowles
Sexual reproduction crucially depends on the production of sperm in males and oocytes in females. Both types of gamete arise from the same precursor, the germ cells. We review the events that characterize the development of germ cells during fetal life as they commit to, and prepare for, oogenesis or spermatogenesis. In females, fetal germ cells enter meiosis, whereas in males they delay meiosis and instead lose pluripotency, activate an irreversible program of prospermatogonial differentiation, and temporarily cease dividing...
August 30, 2017: Annual Review of Genetics
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