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Daniel N Velasco Hernández, Santiago B De Battista, Héctor R Horiuchi, Maria M Zicavo
INTRODUCTION: Although carcinoid tumours are a rare gastrointestinal neoplasm with an incidence rate of 1-2.5 cases per 100 000 inhabitants, they are the most common neuroendocrine tumour of the stomach. PRESENTATION OF CASE: A 70-year-old-man consulted for epigastric pain and dyspepsia symptoms. His past medical and surgical history included obesity (BMI: 53.9 kg/m2 ), hypertension, hyperlipidemia, diabetes mellitus type 2, cardiac failure and a surgical treatment with laparoscopic gastric banding...
September 4, 2018: International Journal of Surgery Case Reports
Fujun Li, Yanqiu You, Hui Zhu
15-Hydroxyeicosatetraenoic acid (15-HETE) is produced by the catalytic metabolism of arachidonic acid by the enzyme 15-lipoxygenase. It is produced during hypoxia, and participates in the remodeling of pulmonary artery smooth muscle (PASM). Previous research has revealed that sirtuin 1 (SIRT1) involved in apoptosis in various cells and tissues. Herein, we attempted to determine whether 15-HETE counteracts SIRT1-promoted cell death in murine PASM cells (PASMCs). To verify this theory, we investigated changes in SIRT1 concentration in response to the counteraction of cell death by 15-HETE...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yuyang Zhou, Min Lin, Jie Wang, Fan Chen, Feiyang Li, Wenge Chen, Longyu Han, Chiahung Wang, Jianming Chen, Jing-Wei Shao, Lee Jia
S-nitrosocaptopril (CapNO) possesses dual capacities of both Captopril and an NO donor with enhanced efficacy and reduced side effects. CapNO crystals are difficult to make due to its unstable S-NO bond. Here, we report a novel stable S-nitrosocaptopril monohydrate (CapNO·H2 O) that is stabilized by intermolecular five-membered structure, where one H of H2 O forms a hydrogen bond with O- of the stable resonance zwitterion Cap-S+ =N-O- , and the O in H2 O forms the dipole-dipole interaction with S+ through two unpaired electrons...
September 15, 2018: Free Radical Biology & Medicine
Huanhuan Hu, Tetsuya Mizoue, Naoko Sasaki, Takayuki Ogasawara, Kentaro Tomita, Satsue Nagahama, Ai Hori, Akiko Nishihara, Teppei Imai, Makoto Yamamoto, Masafumi Eguchi, Takeshi Kochi, Toshiaki Miyamoto, Toru Honda, Tohru Nakagawa, Shuichiro Yamamoto, Hiroko Okazaki, Akihiko Uehara, Makiko Shimizu, Taizo Murakami, Keisuke Kuwahara, Akiko Nanri, Maki Konishi, Isamu Kabe, Seitaro Dohi
BACKGROUND AND AIMS: We aimed to examine the risk of cardiovascular disease (CVD) with persistent prediabetes during the last four years prior to a CVD event in a large occupational cohort in Japan. METHODS: We performed a nested case-control study using data from the Japan Epidemiology Collaboration on Occupational Health Study. A total of 197 registered cases of CVD were identified and matched individually with 985 controls according to age, sex, and worksite...
September 8, 2018: Atherosclerosis
Mikael S Huhtala, Kristiina Tertti, Outi Pellonperä, Tapani Rönnemaa
AIMS: We compared the effects of metformin and insulin treatments of gestational diabetes mellitus (GDM) on amino acid metabolism. METHODS: 217 pregnant women diagnosed with GDM were randomized to receive either metformin or insulin. 1 H nuclear magnetic spectroscopy was used to determine serum concentrations of alanine, glutamine, glycine, isoleucine, leucine, valine, histidine, phenylalanine, tyrosine, glucose and lactate at the time of diagnosis and at 36 gestational weeks (gw)...
September 15, 2018: Diabetes Research and Clinical Practice
Marissa L Zwald, Tala H I Fakhouri, Cheryl D Fryar, Geoffrey Whitfield, Lara J Akinbami
Active transportation (AT), or walking or bicycling for transportation, represents one way individuals can achieve recommended physical activity (PA) levels. This study describes AT prevalence and temporal trends, and examines associations between AT levels and measured CVD risk factors (hypertension, hypercholesterolemia, low high-density [HDL] cholesterol, diabetes, and obesity) among U.S. adults. National Health and Nutrition Examination Survey (NHANES) 2007-2016 data (analyzed in 2017) were used to conduct overall trend analyses of reported AT in a typical week [none (0-9 min/week); low (10-149 min/week); or high (≥150 min/week)]...
September 15, 2018: Preventive Medicine
Xiaowu Wang, Yanzhen Tan, Bo Xu, Linhe Lu, Minggao Zhao, Jipeng Ma, Hongliang Liang, Jincheng Liu, Shiqiang Yu
Premenopausal women have a reduced risk for cardiovascular disease. Estrogen deficiency augments cardiac inflammation and oxidative stress and, thereby, aggravates myocardial fibrosis (MF) and diastolic dysfunction in hypertensive female rats. However, estrogen replacement therapy has no effect on myocardial infarction and cardiac fibrosis in postmenopausal women. Further clinical studies showed that high blood glucose levels in patients with diabetes is an important cause of MF, but the underlying mechanism is unclear...
September 18, 2018: DNA and Cell Biology
Jorge Camargo Oishi, Cynthia Aparecida Castro, Karina Ana Silva, Victor Fabricio, Evelin Capelari Cárnio, Shane A Phillips, Ana Claudia Garcia de Oliveira Duarte, Gerson Jhonatan Rodrigues
BACKGROUND: Obesity leads to a chronic inflammatory state, endothelial dysfunction and hypertension. OBJECTIVE: To establish the time-course of events regarding inflammatory markers, endothelial dysfunction, systolic blood pressure (SBP) in obesity in only one experimental model. METHODS: We fed male Wistar rats (eight-week age) with a standard diet (Control - CT, n = 35), or palatable high-fat diet (HFD, n = 35) for 24 weeks. Every six weeks, 7 animals from each group were randomly selected for euthanasia...
June 2018: Arquivos Brasileiros de Cardiologia
Fabiane R R H Marui, Henrique Tria Bianco, Maria Teresa N Bombig, Natascha G F Palmeira, José M Thalenberg, Fernando Focaccia Povoa, Maria Cristina de O Izar, Francisco Antonio H Fonseca, Acary S B de Oliveira, Rui M S Povoa
BACKGROUND: Duchenne muscular dystrophy is an X-chromosome-linked genetic disorder (locus Xp21). Involvement of the cardiovascular system is characterized by fibrous degeneration/replacement of myocytes with consequent ventricular hypertrophy and arterial hypertension. OBJECTIVE: To assess, by using 24-hour ambulatory blood pressure monitoring, the behavior of blood pressure variables in children and adolescents with a confirmed diagnosis of Duchenne muscular dystrophy...
June 2018: Arquivos Brasileiros de Cardiologia
Luiz Aparecido Bortolotto
No abstract text is available yet for this article.
June 2018: Arquivos Brasileiros de Cardiologia
Arthur Santa Catharina, Rodrigo Modolo, Alessandra Mileni Versuti Ritter, Andréa Rodrigues Sabbatini, Heno Ferreira Lopes, Heitor Moreno Junior, Ana Paula de Faria
BACKGROUND: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence of hypertension and resistant hypertension (RHTN) represent a great area of interest for investigation. OBJECTIVE: The purpose of this study was to evaluate the prevalence of MetS and the clinical features associated with it in resistant and mild to moderate hypertensives. METHODS: This cross-sectional study included 236 patients, (i) 129 mild to moderate hypertensive patients and (ii) 107 patients with RHTN...
June 2018: Arquivos Brasileiros de Cardiologia
Bruno Ramos Nascimento, Luisa Campos Caldeira Brant, Gláucia Maria Moraes de Oliveira, Marcus Vinícius Bolívar Malachias, Gabriel Moreira Alves Reis, Renato Azeredo Teixeira, Deborah Carvalho Malta, Elisabeth França, Maria de Fátima Marinho Souza, Gregory A Roth, Antonio Luiz P Ribeiro
BACKGROUND: Portuguese-speaking countries (PSC) share the influence of the Portuguese culture but have socioeconomic development patterns that differ from that of Portugal. OBJECTIVE: To describe trends in cardiovascular disease (CVD) morbidity and mortality in the PSC between 1990 and 2016, stratified by sex, and their association with the respective sociodemographic indexes (SDI). METHODS: This study used the Global Burden of Disease (GBD) 2016 data and methodology...
June 2018: Arquivos Brasileiros de Cardiologia
Kia C Fuller, Christopher McCarty, Cynthia Seaborn, Clarence C Gravlee, Connie J Mulligan
Deaths due to hypertension in the US are highest among African Americans, who have a higher prevalence of hypertension and more severe hypertensive symptoms. Research indicates that there are both genetic and sociocultural risk factors for hypertension. Racial disparities in hypertension also likely involve genetic and sociocultural factors, but the factors may interact and manifest differently across racial groups. Here we use a biocultural approach to integrate genetic and social network data to better understand variation in blood pressure...
2018: PloS One
Maxime Berney, Michel Burnier, Grégoire Wuerzner
Isolated diastolic hypertension (IDH), defined as a diastolic blood pressure (DBP) > 90 mmHg and a systolic blood pressure (SBP) < 140 mmHg, is a common situation in medical practice. In the elderly, the cardiovascular risk is clearly associated with the level of systolic BP and pulse pressure. However, diastolic BP is also associated with an increased risk of cardiovascular event, in particular among young hypertensive patients (< 50 years old). Therefore, isolated diastolic hypertension should not be neglected...
September 12, 2018: Revue Médicale Suisse
Michel Burnier, Erietta Polychronopoulou, Grégoire Wuerzner
The percentage of patients treated for hypertension with a well-controlled blood pressure (< 140/90 mmHg) remains disappointedly low, in general way below 50 %, despite all national and international recommendations. Among the causes explaining this insufficient control, therapeutic inertia has been identified as an important determinant, which unfortunately did not improve over the last 10‑20 years. Patients' empowerment through home blood pressure monitoring and perhaps self-titration according to a well pre-specified scheme supported by telemedicine could represent news avenues to fight against therapeutic inertia...
September 12, 2018: Revue Médicale Suisse
Antoinette Pechère-Bertschi, Gregoire Wuerzner, Michel Burnier
International guidelines on definitions, therapeutic targets and treatment of arterial hypertension are regularly published by national and international societies in order to help medical doctors to optimally screen and take charge of their patients and to apply the best evidence based medicine. Hypertension remains a major cause of mortality worldwide and is insufficiently well controlled. We present here the new 2017 American guidelines that harbor major changes compared with the previous ones. Even if the new 2017 American definitions and therapeutic targets will not be applied in Europe and Switzerland and perhaps even in United States, it is good to know them even if only to correctly follow medical literature and avoid a certain confusion in managing high blood pressure...
September 12, 2018: Revue Médicale Suisse
Catheline Stancu, Caroline Werner, Antoinette Pechère-Bertschi, Sofia Zisimopoulou
The prevalence of high blood pressure is increasing and expanding preventive and treatment measures may be useful. Some data in the literature suggest that meditation can play a role not only in stress management but also in blood pressure control and cardiovascular disease prevention. Mechanisms involved may be based on the regulation of emotional and biological responses to stress, by regulation of the autonomous nervous system. This approach is available to everyone interested, has no adverse effects and is not related to any particular religious beliefs...
September 12, 2018: Revue Médicale Suisse
Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma
Early‑onset cardiovascular and renal diseases have a strong genetic component. In the present study, exome‑wide association studies (EWASs) were performed to identify genetic variants that confer susceptibility to early‑onset myocardial infarction (MI), hypertension, or chronic kidney disease (CKD) in Japanese individuals. A total of 8,093 individuals aged ≤65 years was enrolled in the study. The EWASs for MI, hypertension, and CKD were performed in 6,926 subjects (1,152 cases, 5,774 controls), 8,080 subjects (3,444 cases, 4,636 controls), and 2,556 subjects (1,051 cases, 1,505 controls), respectively...
September 4, 2018: International Journal of Molecular Medicine
Yu-Zhong Yang, Yun-Feng Zhang, Lei Yang, Jing Xu, Xu-Ming Mo, Wei Peng
MicroRNAs (miRNAs) have a key role in the pathogenesis of pulmonary arterial hypertension (PAH), a disease characterized by enhanced proliferation and reduced apoptosis of pulmonary artery smooth muscle cells. In the present study, miR‑760 was demonstrated to be downregulated in PAH lung tissues compared with normal lung tissues, an effect that may be associated with the development of PAH. Hypoxia is an important stimulus for human pulmonary artery smooth muscle cell (hPASMC) proliferation and the occurrence of PAH...
September 7, 2018: International Journal of Molecular Medicine
Tania I Nava-Bringas, Laura López-Domínguez, Salvador I Macías-Hernández, Rolando Espinosa-Morales, Daniel D Chávez-Arias, Roberto Coronado-Zarco
Introducción: Las alteraciones en la composición corporal total podrían influir sobre la fuerza, el dolor y la discapacidad en pacientes con espondiloartrosis lumbar. Objetivo: Analizar la asociación de la composición corporal total con la fuerza muscular del tronco, el dolor y la discapacidad en pacientes con espondiloartrosis lumbar. Método: Estudio piloto en mayores de 50 años con dolor crónico de espalda baja y espondiloartrosis lumbar...
2018: Cirugia y Cirujanos
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