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Pantelis A Sarafidis, Francesca Mallamaci, Charalampos Loutradis, Robert Ekart, Claudia Torino, Antonios Karpetas, Vasileios Raptis, Athanasios Bikos, Aikaterini Papagianni, Olga Balafa, Konstantinos Siamopoulos, Giovanni Pisani, Massimo Morosetti, Antonio Del Giudice, Fillipo Aucella, Luca Di Lullo, Rocco Tripepi, Giovanni Tripepi, Kitty Jager, Friedo Dekker, Gerard London, Carmine Zoccali
Background: Population-specific consensus documents recommend that the diagnosis of hypertension in haemodialysis patients be based on 48-h ambulatory blood pressure (ABP) monitoring. However, until now there is just one study in the USA on the prevalence of hypertension in haemodialysis patients by 44-h recordings. Since there is a knowledge gap on the problem in European countries, we reassessed the problem in the European Cardiovascular and Renal Medicine working group Registry of the European Renal Association-European Dialysis and Transplant Association...
July 10, 2018: Nephrology, Dialysis, Transplantation
S Damanti, C Abbate, I Chiodini, M Cesari, T Nestola, G Belloni, C Mandelli, D Mari, T Lucchi
An 81-year-old woman was hospitalised for behavioural disorders that had been progressively emerging over a period of few weeks. The symptoms appeared to worsen over time. A diagnosis of vascular dementia, complicated by psychosis, was initially hypothesised. The inefficacy of the antipsychotic/benzodiazepine medications used, along with the presence of hypertension, hypokalaemia and metabolic alkalosis (resistant to pharmacological attempts of correction), as well as the hirsutism and the development of several infections, led us to consider Cushing's syndrome...
July 10, 2018: Age and Ageing
Franka Messner, Claudia Bösmüller, Rupert Oberhuber, Manuel Maglione, Benno Cardini, Thomas Resch, Stefan Scheidl, Dietmar Öfner, Stefan Schneeberger, Christian Margreiter
In response to a number of late, repetitive bleeding episodes from the site of the enteric anastomosis, we herein analyze the clinical courses and etiologies of 379 consecutively performed pancreas transplants between January 2000 and December 2016. Duodenojejunostomies for enteric drainage were performed at the upper jejunum in a side to side, double layer fashion. Five patients (1.3%) developed recurrent late hemorrhagic episodes originating from the graft duodenal anastomosis. Bleeding from the anastomotic site was associated with hematochezia, hemodynamic instability and decrease of serum hemoglobin...
July 14, 2018: Clinical Transplantation
Mark Waldron, Stephen David Patterson, Jamie Tallent, Owen Jeffries
PURPOSE OF REVIEW: The aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans. RECENT FINDINGS: There is growing evidence that taurine deficiency is associated with hypertension and that oral supplementation can have antihypertensive effects in humans. However, these investigations have been conducted across a number of decades and populations and have not been collectively reviewed...
July 13, 2018: Current Hypertension Reports
M V Vasin, T S Gan'shina, R S Mirzoyan, L A Semenova, L V Koroleva, R V Afanas'ev, I B Ushakov
We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound...
July 13, 2018: Bulletin of Experimental Biology and Medicine
G Leuschner, C Neurohr
BACKGROUND: Pulmonary involvement in patients with underlying autoimmune diseases poses a major diagnostic and therapeutic challenge to the treating physician. Due to the associated increased mortality risk, early diagnosis is crucial. OBJECTIVE: The incidence and mortality rate of connective tissue disease-related interstitial lung diseases (CTD-ILD) and pulmonary hypertension (PH) were evaluated in patients with rheumatic disease including clinical aspects, diagnostic procedure, prognosis and treatment recommendations...
July 13, 2018: Zeitschrift Für Rheumatologie
Cheng Peng, Xiao-Hui Dong, Jia-Lin Liu, Yu-Long Tao, Chun-Fang Xu, Li-Ping Wang, Chun-Long Liu, Ding-Feng Su, Xia Tao, Chuan Zhang, Alex F Chen, He-Hui Xie
There is a pressing need for new approaches to preventing stroke. Endothelial progenitor cells (EPCs) promote vascular repair and revascularization in the ischemic brain. This study sought to evaluate whether preventive delivery of EPCs could prevent or protect against stroke. Stroke-prone spontaneously hypertensive rats (SHR-SP) received a single injection of EPCs, and their survival time was monitored. In addition, at 28 and/or 42 days after a single injection of EPCs, SHR-SP and mice were subjected to cerebral ischemia, and cerebral ischemic injury, local angiogenesis and in vivo EPC integration were determined...
July 13, 2018: Clinical Science (1979-)
Robert P Nolan, Ross Feldman, Martin Dawes, Janusz Kaczorowski, Hazel Lynn, Susan I Barr, Carolyn MacPhail, Scott Thomas, Jack Goodman, Gunther Eysenbach, Sam Liu, Rika Tanaka, Jelena Surikova
BACKGROUND: The efficacy of internet-based interventions to improve hypertension management is not established. We evaluated the therapeutic benefit of e-counseling by adapting best evidence guidelines for behavioral counseling. METHODS AND RESULTS: This multicenter double-blind randomized controlled trial included assessments at baseline, 4 months, and 12 months. Participants were 35 to 74 years of age and diagnosed with hypertension: systolic/diastolic blood pressure (BP) 130 to 180/85 to 110 mm Hg...
July 2018: Circulation. Cardiovascular Quality and Outcomes
Elaine Ku, Joachim H Ix, Kenneth Jamerson, Navdeep Tangri, Feng Lin, Jennifer Gassman, Miroslaw Smogorzewski, Mark J Sarnak
BACKGROUND: During intensive BP lowering, acute declines in renal function are common, thought to be hemodynamic, and potentially reversible. We previously showed that acute declines in renal function ≥20% during intensive BP lowering were associated with higher risk of ESRD. Here, we determined whether acute declines in renal function during intensive BP lowering were associated with mortality risk among 1660 participants of the African American Study of Kidney Disease and Hypertension and the Modification of Diet in Renal Disease Trial...
July 13, 2018: Journal of the American Society of Nephrology: JASN
Shadi Saleh, Angie Farah, Hani Dimassi, Nour El Arnaout, Joanne Constantin, Mona Osman, Christo El Morr, Mohamad Alameddine
BACKGROUND: Rural areas and refugee camps are characterized by poor access of patients to needed noncommunicable disease (NCD)-related health services, including diabetes and hypertension. Employing low-cost innovative eHealth interventions, such as mobile health (mHealth), may help improve NCDs prevention and control among disadvantaged populations. OBJECTIVE: The aim of this study was to assess the effect of employing low-cost mHealth tools on the accessibility to health services and improvement of health indicators of individuals with NCDs in rural areas and refugee camps in Lebanon...
July 13, 2018: JMIR MHealth and UHealth
Stefan Lc Geijselaers, Simone Js Sep, Miranda T Schram, Martin Pj van Boxtel, Thomas T van Sloten, Jos Op Het Roodt, Ronald Ma Henry, Koen D Reesink, Nicolaas C Schaper, Pieter C Dagnelie, Carla Jh van der Kallen, Geert Jan Biessels, Coen DA Stehouwer
BACKGROUND AND AIMS: Arterial remodelling aims at normalising circumferential wall stress (CWS). Greater CWS in the carotid artery has previously been associated with the prevalence and severity of cerebral small vessel disease, a major cause of ageing-related cognitive decline. Here we test the hypothesis that greater carotid CWS is associated with poorer cognitive performance. METHODS: We studied 722 individuals (60 ± 8 years, 55% men, 42.5% highly educated, blood pressure 137 ± 19/77 ± 11 mmHg, n = 197 with type 2 diabetes) who completed a neuropsychological assessment and underwent vascular ultrasound to measure the intima-media thickness (IMT) and interadventitial diameter (IAD) of the left common carotid artery at a plaque-free site...
July 4, 2018: Atherosclerosis
Michael M Aziz, Ankita Kulkarni, Oluwafisayo Tunde-Agbede, Carlos W Benito, Yinka Oyelese
OBJECTIVE: To determine if women who present to the labor and delivery unit at 23 0/7 to 36 6/7 weeks gestation with threatened preterm labor (TPTL) are more likely to be dehydrated than women who present at the same gestational age for other reasons. DESIGN: Retrospective cohort study. SETTING: An academic medical center in the northeastern United States. PARTICIPANTS: All women at preterm gestational ages 23 0/7 to 36 6/7 weeks who presented to the labor and delivery unit for care in 2014...
July 10, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Benjamin K Ruth, Kenneth C Bilchick, Manu M Mysore, Hunter Mwansa, William C Harding, Younghoon Kwon, Jamie L W Kennedy, Jeremy A Mazurek, Andrew D Mihalek, LaVone A Smith, Eliany Mejia-Lopez, Alex M Parker, Timothy S Welch, Sula Mazimba
BACKGROUND: Pulmonary arterial hypertension (PAH) is characterised by remodelling of the pulmonary vasculature leading to right ventricular (RV) failure. The failing RV, through interventricular uncoupling, deleteriously impacts the left ventricle and overall cardiac efficiency. We hypothesised that the ratio of the pulmonary artery pulse pressure to the systemic pulse pressure ("pulmonary-systemic pulse pressure ratio", or PS-PPR) would be associated with mortality in PAH. METHODS: We conducted a retrospective analysis of 262 patients in the National Institute of Health Primary Pulmonary Hypertension Registry (NIH-PPH)...
June 21, 2018: Heart, Lung & Circulation
Tiantian Ji, Yingxin Zhao, Juan Wang, Yi Cui, Dandan Duan, Qiang Chai, Hua Zhang, Zhendong Liu
OBJECTIVES: To investigate the effect of low-dose statins and apolipoprotein E (APOE) genotypes on cerebral small vessel disease (CSVD) to prevent CSVD in older hypertensive patients. DESIGN: A subgroup analysis of a randomized clinical trial. SETTING: Shandong area, China. PARTICIPANTS: Hypertensive patients aged ≥60 years were recruited from April 2008 to November 2010. MEASUREMENTS: Patients were randomly assigned to rosuvastatin (10 mg/day) or placebo groups...
July 10, 2018: Journal of the American Medical Directors Association
Barbara E Adams, Joshua P Edlinger, Miranda L Ritterman Weintraub, Jason D Pollard
Patients requiring a nontraumatic transmetatarsal amputation (TMA) typically have multiple comorbidities that place them at high risk of postoperative complications and additional surgery. The present study identified the demographic, clinical, and surgical risk factors that predict complications after a nontraumatic TMA, including the incidence of 3-year mortality, proximal limb amputation, and lack of healing. The electronic medical records of patients who had undergone TMA within a Kaiser Permanente Northern California facility from March 2007 to January 2012 (n = 375) were reviewed...
July 10, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Hope Bussenius, Angela M Zeck, Bryan Williams, Angela Haynes-Ferere
INTRODUCTION: Elevated blood pressure is becoming increasingly common in the pediatric population. Hypertension costs nearly $51 billion/year, and cardiovascular disease is responsible for 17% of the nation's health care expenditures. Traditionally, time-consuming and complicated interpretation standards result in infrequent pediatric blood pressure screenings. This may lead to the under-diagnosis of pediatric hypertension. Early detection of elevated blood pressure is important in order to prevent hypertension related conditions such as, target organ damage, left ventricular hypertrophy, and cerebrovascular disease...
July 10, 2018: Journal of Pediatric Health Care
Elisabetta Zanatta, Pamela Polito, Mariangela Favaro, Maddalena Larosa, Piero Marson, Franco Cozzi, Andrea Doria
Scleroderma renal crisis (SRC) is an uncommon but still life-threatening manifestation of systemic sclerosis (SSc). The incidence of SRC has decreased in the last few decades, probably due to a widespread use of vasodilators in SSc patients. It is well-recognized that exposure to different drugs can trigger SRC (corticosteroids, cyclosporine) or prevent its occurrence (iloprost, calcium channel blockers). The prognosis of this life-threatening manifestation has not substantially improved since 1980s, when ACE-inhibitors were introduced in its treatment...
July 10, 2018: Autoimmunity Reviews
Marianna Virtanen, Jussi Vahtera, Archana Singh-Manoux, Marko Elovainio, Jane E Ferrie, Mika Kivimäki
BACKGROUND: Few studies have examined long-term associations of unfavorable and favorable changes in vascular risk factors with incident coronary heart disease (CHD). We examined this issue in a middle-aged disease-free population. METHODS: We used repeat data from the Whitehall II cohort study. Five biomedical, behavioral and psychosocial examinations of 8335 participants without CHD produced up to 20,357 person-observations to mimic a non-randomized pseudo-trial...
July 5, 2018: International Journal of Cardiology
Yang Mi, Qin Wu, Wanru Yuan, Fuxue Chen, Dongshu Du
The lack of precise therapies for stress-induced hypertension highlights the need to explore the process of blood pressure changes. Studies have shown that neuroinflammation in the central nervous system is associated with hypertension, although the mechanisms remain elusive. Microglia, are known to play dualistic protective and destructive roles, representing logical but challenging targets for improving stress-induced hypertension. Here, as a model, we used rats with stress-induced hypertension, and found that a switch from an immunoregulatory (M2) to a pro-inflammatory (M1) dominant response occurred in microglia during development of stress-induced hypertension...
September 2018: Autonomic Neuroscience: Basic & Clinical
Tatsuo Takamiya, Yukiko Kubo, Peyman Benharash, Wei Zhou
Augmentation of cardiac sympathetic tone has been shown to induce ventricular arrhythmias. Acupuncture has been clinically used to treat hypertension, angina pectoris, and atrial arrhythmias. However, the effects of acupuncture on ventricular electrophysiology and autonomic tone remain unknown. We hypothesized that acupuncture attenuates cardiac excitability and corrects the imbalance of autonomic tone during sympathetic hyperactivity. Fourteen Yorkshire pigs were randomized to electroacupuncture (EA, 2 Hz, 0...
September 2018: Autonomic Neuroscience: Basic & Clinical
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