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Lennox gastaut anaesthesia

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https://www.readbyqxmd.com/read/12521358/stimulation-of-the-nervous-system-for-the-management-of-seizures-current-and-future-developments
#1
REVIEW
Jerome V Murphy, Arunangelo Patil
Vagal nerve stimulation (VNS) for the treatment of refractory epilepsy appears to have started from the theory that since VNS can alter the EEG, it may influence epilepsy. It proved effective in several models of epilepsy and was then tried in short-term, open-label and double-blind trials, leading to approval in Canada, Europe and the US. Follow-up observations in these patients demonstrated continued improvement in seizure control for up to 2 years. Close to 50% of treated patients have achieved at least a 50% reduction in seizure frequency...
2003: CNS Drugs
https://www.readbyqxmd.com/read/3239696/can-barbiturate-anaesthesia-cure-infantile-spasms
#2
R Riikonen, P Santavuori, O Meretoja, K Sainio, P J Neuvonen, R A Tokola
Five patients with infantile spasms and hypsarrhythmia and one with Lennox-Gastaut syndrome were treated with brief thiopentone anaesthesia as the primary treatment of infantile spasms. Thiopentone (30 mg/kg) was given intravenously and burst suppression was reached in EEG in three patients by this dose. The results were disappointing. In three patients a transient beneficial effect on spasms and hypsarrhythmia was seen, but all patients relapsed. Three other patients had anaesthesia for surgery. The spasms ceased and hypsarrhythmia disappeared dramatically, and the effect was permanent...
1988: Brain & Development
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