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https://www.readbyqxmd.com/read/28260159/emerging-biomarkers-and-screening-for-cognitive-frailty
#1
REVIEW
Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Madia Lozupone, Davide Seripa, Francesco Panza, Zhuowei Yu
Physical frailty and cognitive frailty are two important targets of secondary intervention in aging research to narrow the gap between life and health span. The objective of the present narrative review was to examine clinical and epidemiological studies investigating the recently proposed construct of cognitive frailty and its subtypes, with a focus on operational definitions, clinical criteria, and emerging biomarkers potentially useful for the screening of this novel entity. Both physical frailty and frailty indexes with a multidimensional nature were associated with late-life cognitive impairment/decline, incident dementia, Alzheimer's disease (AD), mild cognitive impairment, vascular dementia, non-AD dementias, and AD pathology proposing cognitive frailty as a clinical entity with cognitive impairment related to physical causes with a potential reversibility...
March 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28112769/assessing-the-current-state-of-cognitive-frailty-measurement-properties
#2
L Sargent, R Brown
BACKGROUND: Currently, an estimated 25-30% of people ages 85 or older have dementia, with a projected 115 million people worldwide living with dementia by 2050. With this worldwide phenomenon fast approaching, early detection of at-risk older adults and development of interventions focused on preventing loss in quality of life are increasingly important. A new construct defined by the International Consensus Group (I.A.N.A/I.A.G.G) as «cognitive frailty» combines domains of physical frailty with cognitive impairment and provides a framework for research that may provide a means to identify individuals with cognitive impairment caused by nonneurodegenerative conditions...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28012505/reversible-cognitive-frailty-dementia-and-all-cause-mortality-the-italian-longitudinal-study-on-aging
#3
Vincenzo Solfrizzi, Emanuele Scafato, Davide Seripa, Madia Lozupone, Bruno P Imbimbo, Angela D'Amato, Rosanna Tortelli, Andrea Schilardi, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Antonio Daniele, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza
OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role. DESIGN: Longitudinal population-based study with 3...
January 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27753800/ssa-01-3-elderly-hypertension-not-the-chronology-but-the-pathophysiology
#4
Katsuhiko Kohara
The effectiveness of antihypertensive treatment in elderly hypertensive patients has been established through numerous randomized clinical trials including the Hypertension in the Very Elderly Trial (HYVET). However, because of the diversity of biological aging among individuals, chronological age is not the sole determinant for the target blood pressure (BP) level at which antihypertensive medications are aimed. Several conditions, especially frailty, needed be evaluated in managing hypertension among elderly people...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749714/the-relevance-of-nutrition-for-the-concept-of-cognitive-frailty
#5
Ligia J Dominguez, Mario Barbagallo
PURPOSE OF REVIEW: Physical and cognitive frailty are interrelated and synergistic syndromes more frequently seen in old age, which represent intermediate stages between aging successfully and disability. Poor nutrition is a fundamental determinant for both conditions, while various dietary components are proposed to prevent and/or improve them. This updated review discusses the possible influence of nutritional factors on cognitive frailty and its potential mediators. RECENT FINDINGS: Oxidative stress, low-grade systemic inflammation, neuroinflammation, and altered autophagy, all associated with obesity, metabolic syndrome and insulin resistance, are proposed mechanisms to explain the influence of nutrition on cognitive health...
January 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27642869/ssa-01-3-elderly-hypertension-not-the-chronology-but-the-pathophysiology
#6
Katsuhiko Kohara
The effectiveness of antihypertensive treatment in elderly hypertensive patients has been established through numerous randomized clinical trials including the Hypertension in the Very Elderly Trial (HYVET). However, because of the diversity of biological aging among individuals, chronological age is not the sole determinant for the target blood pressure (BP) level at which antihypertensive medications are aimed. Several conditions, especially frailty, needed be evaluated in managing hypertension among elderly people...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27570509/the-early-indicators-of-functional-decrease-in-mild-cognitive-impairment
#7
Alexandre Kubicki, Lilian Fautrelle, Julien Bourrelier, Olivier Rouaud, France Mourey
OBJECTIVES: Motor deficiency is associated with cognitive frailty in patients with Mild Cognitive Impairments (MCI). In this study we aimed to test the integrity in muscle synergies involved in an arm-pointing movement in functionally unimpaired MCI patients. We hypothesized that early motor indicators exist in this population at a preclinical level. METHODS: Electromyographic signals were collected for 11 muscles in 3 groups: Young Adults (YA), Older Adults (OA), and MCI patients...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27547746/neuropsychological-profile-of-cognitive-frailty-subjects-in-mapt-study
#8
J Delrieu, S Andrieu, M Pahor, C Cantet, M Cesari, P J Ousset, T Voisin, B Fougère, S Gillette, I Carrie, B Vellas
OBJECTIVES: An international group proposed the existence of "cognitive frailty", a condition defined by simultaneous presence of physical frailty and cognitive impairment in the absence of dementia. The objective was to compare the neuropsychological profiles in subgroups of elders differentiated across their physical frailty (Fried phenotype) and cognitive status (Clinical Dementia Rating score) to characterize the "cognitive frailty" entity. METHOD: We studied baseline characteristics of 1,617 subjects enrolled in Multidomain Alzheimer Disease Preventive Trial (MAPT)...
June 2016: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/27525276/alzheimer-s-disease-and-cognitive-frailty-novel-therapeutic-technologies
#9
Grazia D'Onofrio, Zhuowei Yu, Orestes V Forlenza
No abstract text is available yet for this article.
2016: BioMed Research International
https://www.readbyqxmd.com/read/27511317/potential-fluid-biomarkers-for-pathological-brain-changes-in-alzheimer-s-disease-implication-for-the-screening-of-cognitive-frailty
#10
REVIEW
Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Zhuowei Yu
Cognitive frailty (CF) overlaps with early neuropathological alterations associated with aging‑related major neurocognitive disorders, including Alzheimer's disease (AD). Fluid biomarkers for these pathological brain alterations allow for early diagnosis in the preclinical stages of AD, and for objective prognostic assessments in clinical intervention trials. These biomarkers may also be helpful in the screening of CF. The present study reviewed the literature and identified systematic reviews of cohort studies and other authoritative reports...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27499306/impact-of-cognitive-frailty-on-daily-activities-in-older-persons
#11
H Shimada, H Makizako, S Lee, T Doi, S Lee, K Tsutsumimoto, K Harada, R Hotta, S Bae, S Nakakubo, K Harada, T Suzuki
OBJECTIVES: To identify the relationships between physical and/or cognitive frailty and instrumental activities of daily living (IADL) functioning in community living older persons. DESIGN: Cross sectional observation study. SETTING: Data extracted from the 2011-2013 of the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes (NCGG-SGS) database. PARTICIPANTS: A total of 8,864 older adults aged ≥ 65 years who were enrolled in the NCGG-SGS...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27282417/cognitive-impairment-improves-the-predictive-validity-of-physical-frailty-for-mortality-in-patients-with-advanced-heart-failure-referred-for-heart-transplantation
#12
Sunita R Jha, Malin K Hannu, Keren Gore, Sungwon Chang, Phillip Newton, Kay Wilhelm, Christopher S Hayward, Andrew Jabbour, Eugene Kotlyar, Anne Keogh, Kumud Dhital, Emily Granger, Paul Jansz, Phillip M Spratt, Elyn Montgomery, Michelle Harkess, Peta Tunicliff, Patricia M Davidson, Peter S Macdonald
BACKGROUND: The aim of this study was to identify whether the addition of cognitive impairment, depression, or both, to the assessment of physical frailty provides better outcome prediction in patients with advanced heart failure referred for heart transplantation (HT). METHODS: Beginning in March 2013, all patients with advanced heart failure referred to our Transplant Unit have undergone a physical frailty assessment using the Fried frailty phenotype. Cognition was assessed with the Montreal Cognitive Assessment and depression with the Depression in Medical Illness questionnaire...
September 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27092934/the-treviso-dementia-tredem-study-a-biomedical-neuroradiological-neuropsychological-and-social-investigation-of-dementia-in-north-eastern-italy
#13
M Gallucci, E Mariotti, D Saraggi, T Stecca, M G Oddo, C Bergamelli, P Boldrini, S Mazzuco, F Ongaro, P Mecocci, F Di Paola, M Bendini, G L Forloni, D Albani, P Antuono, L Caberlotto, A Zanardo, M Siculi, G B Gajo, E Durante, G Buscato
BACKGROUND: The incidence of dementia increases exponentially with age but knowledge of real disease-modifying interventions is still limited. OBJECTIVES: To describe the study design and methods of a large prospective cohort study aimed at exploring the complex underlying relationships existing among cognition, frailty, and health-related events in older persons with cognitive impairment. DESIGN: Prospective cohort study of a representative population of outpatients attending the Treviso Cognitive Impairment Center between 2000 and 2010...
2012: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27049899/editorial-the-complex-construct-of-mild-cognitive-impairment-be-aware-of-cognitive-frailty
#14
M Canevelli, E Kelaiditi
No abstract text is available yet for this article.
2014: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27013397/physical-frailty-cognitive-impairment-and-the-risk-of-neurocognitive-disorder-in-the-singapore-longitudinal-ageing-studies
#15
Liang Feng, Ma Shwe Zin Nyunt, Qi Gao, Lei Feng, Tih Shih Lee, Tung Tsoi, Mei Sian Chong, Wee Shiong Lim, Simon Collinson, Philip Yap, Keng Bee Yap, Tze Pin Ng
Background: The independent and combined effects of physical and cognitive domains of frailty in predicting the development of mild cognitive impairment (MCI) or dementia are not firmly established. Methods: This study included cross-sectional and longitudinal analyses of physical frailty (Cardiovascular Health Study criteria), cognitive impairment (Mini-Mental State Examination [MMSE]), and neurocognitive disorder (DSM-5 criteria) among 1,575 community-living Chinese older adults from the Singapore Longitudinal Ageing Studies...
March 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/26984391/disentangling-cognitive-frailty-results-from-the-gait-and-brain-study
#16
Manuel M Montero-Odasso, Brittany Barnes, Mark Speechley, Susan W Muir Hunter, Timothy J Doherty, Gustavo Duque, Karen Gopaul, Luciano A Sposato, Alvaro Casas-Herrero, Michael J Borrie, Richard Camicioli, Jennie L Wells
BACKGROUND: Cognitive-frailty, defined as the presence of both frailty and cognitive impairment, is proposed as a distinctive entity that predicts dementia. However, it remains controversial whether frailty alone, cognitive-frailty, or the combination of cognitive impairment and slow gait pose different risks of incident dementia. METHODS: Two hundred and fifty-two older adults free of dementia at baseline (mean age 76.6±8.6 years) were followed up to 5 years with bi-annual visits including medical, cognitive, and gait assessments...
November 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/26980362/exercise-an-important-key-to-prevent-physical-and-cognitive-frailty
#17
EDITORIAL
M C Dulac, M Aubertin-Leheudre
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/26715536/prospective-longitudinal-study-of-frailty-transitions-in-a-community-dwelling-cohort-of-older-adults-with-cognitive-impairment
#18
Mei Sian Chong, Laura Tay, Mark Chan, Wee Shiong Lim, Ruijing Ye, Eng King Tan, Yew Yoong Ding
BACKGROUND: Frailty and cognitive impairment are seemingly distinct syndromes, but have a shared vulnerability to stress in older adults, resulting in poorer outcomes. Although there has been recent interest in cognitive frailty, frailty transitions in relation to cognitive deterioration in older adults with cognitive impairment have not yet been well studied. We thus aim to study frailty transitions and change in cognitive status over 1-year follow-up among subjects with cognitive impairment attending a tertiary Memory Clinic...
December 29, 2015: BMC Geriatrics
https://www.readbyqxmd.com/read/26545250/nutrition-frailty-cognitive-frailty-and-prevention-of-disabilities-with-aging
#19
Sophie Guyonnet, Marion Secher, Bruno Vellas
Older adults can be categorized into three subgroups to better design and develop personalized interventions: the disabled (those needing assistance in the accomplishment of basic activities of daily living), the 'frail' (those presenting limitations and impairments in the absence of disability) and the 'robust' (those without frailty or disability). However, despite evidence linking frailty with a poor outcome, frailty is not implemented clinically in most countries. Since many people are not identified as frail, their treatment is frequently inappropriate in health care settings...
2015: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/26484671/frailty-clinical-phenotype-a-physical-and-cognitive-point-of-view
#20
REVIEW
Mylene Aubertin-Leheudre, Adam J Woods, Stephen Anton, Ronald Cohen, Marco Pahor
Frailty is recognized as a clinical geriatric syndrome used to describe the weakest or most vulnerable older adults. Although the term frailty is commonly used in clinical practice, and the theoretical phenomenon is well accepted, it remains an evolving concept that lacks a universally accepted definition and specific diagnostic criteria. Different perspectives on frailty have led to two distinct viewpoints of this phenomenon in the literature. The first describes the phenomenon based solely on physical attributes and capabilities...
2015: Nestlé Nutrition Institute Workshop Series
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