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"cognitive frailty"

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https://www.readbyqxmd.com/read/28843528/cognitive-frailty-far-from-clinical-and-research-adoption
#1
EDITORIAL
Marco Canevelli, Matteo Cesari
No abstract text is available yet for this article.
October 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28797589/association-between-frailty-and-cognitive-impairment-cross-sectional-data-from-toulouse-frailty-day-hospital
#2
Bertrand Fougère, Matthieu Daumas, Matthieu Lilamand, Sandrine Sourdet, Julien Delrieu, Bruno Vellas, Gabor Abellan van Kan
BACKGROUND: A consensus panel, based on epidemiologic evidence, argued that physical frailty is often associated with cognitive impairment, possibly because of common underlying pathophysiological mechanisms. The concepts of cognitive frailty and motoric cognitive risk were recently proposed in literature and may represent a prodromal stage for neurodegenerative diseases. The purpose of this study was to analyze the relationship between cognition and the components of the physical phenotype of frailty...
August 7, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28689645/additive-role-of-a-potentially-reversible-cognitive-frailty-model-and-inflammatory-state-on-the-risk-of-disability-the-italian-longitudinal-study-on-aging
#3
Vincenzo Solfrizzi, Emanuele Scafato, Madia Lozupone, Davide Seripa, Michele Giannini, Rodolfo Sardone, Caterina Bonfiglio, Daniela I Abbrescia, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Antonio Daniele, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza
OBJECTIVE: Cognitive frailty is a condition recently defined by operationalized criteria describing the simultaneous presence of physical frailty and mild cognitive impairment (MCI). Two subtypes for this clinical construct have been proposed: "potentially reversible" cognitive frailty (physical frailty plus MCI) and "reversible" cognitive frailty (physical frailty plus pre-MCI subjective cognitive decline). Here the prevalence of a potentially reversible cognitive frailty model was estimated...
July 6, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28689567/cognitive-frailty-mechanisms-tools-to-measure-prevention-and-controversy
#4
REVIEW
Bertrand Fougère, Julien Delrieu, Natalia Del Campo, Gaëlle Soriano, Sandrine Sourdet, Bruno Vellas
Physical frailty is often associated with cognitive impairment, possibly because of common underlying pathophysiologic mechanisms. To stimulate research in this field, the concept cognitive frailty was proposed, emphasizing the important role of brain aging. Cognitive frailty was defined as the presence of cognitive deficits in physically frail older persons without dementia. This subtype of frailty is deemed important, as it may represent a prodromal phase for neurodegenerative diseases and is potentially a suitable target for early intervention...
August 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/28537326/cognitive-frailty-in-italian-community-dwelling-older-adults-prevalence-rate-and-its-association-with-disability
#5
M Roppolo, A Mulasso, E Rabaglietti
Cognitive frailty is the simultaneous clinical manifestation of both physical frailty and cognitive impairment. This paper aimed to propose and test an operational definition of cognitive frailty. The following specific aims were pursued: (i) to rate the prevalence of cognitive frailty; (ii) to evaluate differences in cognitive functioning among robust, pre-frail, and frail individuals; (iii) to examine the association of cognitive frailty with disability, in a sample of Italian community-dwelling older adults...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28260159/emerging-biomarkers-and-screening-for-cognitive-frailty
#6
REVIEW
Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Madia Lozupone, Davide Seripa, Francesco Panza, Zhuowei Yu
Physical frailty and cognitive frailty are two important targets of secondary intervention in aging research to narrow the gap between life and health span. The objective of the present narrative review was to examine clinical and epidemiological studies investigating the recently proposed construct of cognitive frailty and its subtypes, with a focus on operational definitions, clinical criteria, and emerging biomarkers potentially useful for the screening of this novel entity. Both physical frailty and frailty indexes with a multidimensional nature were associated with late-life cognitive impairment/decline, incident dementia, Alzheimer's disease (AD), mild cognitive impairment, vascular dementia, non-AD dementias, and AD pathology proposing cognitive frailty as a clinical entity with cognitive impairment related to physical causes with a potential reversibility...
March 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28112769/assessing-the-current-state-of-cognitive-frailty-measurement-properties
#7
REVIEW
L Sargent, R Brown
BACKGROUND: Currently, an estimated 25-30% of people ages 85 or older have dementia, with a projected 115 million people worldwide living with dementia by 2050. With this worldwide phenomenon fast approaching, early detection of at-risk older adults and development of interventions focused on preventing loss in quality of life are increasingly important. A new construct defined by the International Consensus Group (I.A.N.A/I.A.G.G) as «cognitive frailty» combines domains of physical frailty with cognitive impairment and provides a framework for research that may provide a means to identify individuals with cognitive impairment caused by nonneurodegenerative conditions...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28012505/reversible-cognitive-frailty-dementia-and-all-cause-mortality-the-italian-longitudinal-study-on-aging
#8
Vincenzo Solfrizzi, Emanuele Scafato, Davide Seripa, Madia Lozupone, Bruno P Imbimbo, Angela D'Amato, Rosanna Tortelli, Andrea Schilardi, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Antonio Daniele, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza
OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role. DESIGN: Longitudinal population-based study with 3...
January 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27753800/ssa-01-3-elderly-hypertension-not-the-chronology-but-the-pathophysiology
#9
Katsuhiko Kohara
The effectiveness of antihypertensive treatment in elderly hypertensive patients has been established through numerous randomized clinical trials including the Hypertension in the Very Elderly Trial (HYVET). However, because of the diversity of biological aging among individuals, chronological age is not the sole determinant for the target blood pressure (BP) level at which antihypertensive medications are aimed. Several conditions, especially frailty, needed be evaluated in managing hypertension among elderly people...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749714/the-relevance-of-nutrition-for-the-concept-of-cognitive-frailty
#10
Ligia J Dominguez, Mario Barbagallo
PURPOSE OF REVIEW: Physical and cognitive frailty are interrelated and synergistic syndromes more frequently seen in old age, which represent intermediate stages between aging successfully and disability. Poor nutrition is a fundamental determinant for both conditions, while various dietary components are proposed to prevent and/or improve them. This updated review discusses the possible influence of nutritional factors on cognitive frailty and its potential mediators. RECENT FINDINGS: Oxidative stress, low-grade systemic inflammation, neuroinflammation, and altered autophagy, all associated with obesity, metabolic syndrome and insulin resistance, are proposed mechanisms to explain the influence of nutrition on cognitive health...
January 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27642869/ssa-01-3-elderly-hypertension-not-the-chronology-but-the-pathophysiology
#11
Katsuhiko Kohara
The effectiveness of antihypertensive treatment in elderly hypertensive patients has been established through numerous randomized clinical trials including the Hypertension in the Very Elderly Trial (HYVET). However, because of the diversity of biological aging among individuals, chronological age is not the sole determinant for the target blood pressure (BP) level at which antihypertensive medications are aimed. Several conditions, especially frailty, needed be evaluated in managing hypertension among elderly people...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27570509/the-early-indicators-of-functional-decrease-in-mild-cognitive-impairment
#12
Alexandre Kubicki, Lilian Fautrelle, Julien Bourrelier, Olivier Rouaud, France Mourey
OBJECTIVES: Motor deficiency is associated with cognitive frailty in patients with Mild Cognitive Impairments (MCI). In this study we aimed to test the integrity in muscle synergies involved in an arm-pointing movement in functionally unimpaired MCI patients. We hypothesized that early motor indicators exist in this population at a preclinical level. METHODS: Electromyographic signals were collected for 11 muscles in 3 groups: Young Adults (YA), Older Adults (OA), and MCI patients...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27547746/neuropsychological-profile-of-cognitive-frailty-subjects-in-mapt-study
#13
J Delrieu, S Andrieu, M Pahor, C Cantet, M Cesari, P J Ousset, T Voisin, B Fougère, S Gillette, I Carrie, B Vellas
OBJECTIVES: An international group proposed the existence of "cognitive frailty", a condition defined by simultaneous presence of physical frailty and cognitive impairment in the absence of dementia. The objective was to compare the neuropsychological profiles in subgroups of elders differentiated across their physical frailty (Fried phenotype) and cognitive status (Clinical Dementia Rating score) to characterize the "cognitive frailty" entity. METHOD: We studied baseline characteristics of 1,617 subjects enrolled in Multidomain Alzheimer Disease Preventive Trial (MAPT)...
June 2016: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/27525276/alzheimer-s-disease-and-cognitive-frailty-novel-therapeutic-technologies
#14
Grazia D'Onofrio, Zhuowei Yu, Orestes V Forlenza
No abstract text is available yet for this article.
2016: BioMed Research International
https://www.readbyqxmd.com/read/27511317/potential-fluid-biomarkers-for-pathological-brain-changes-in-alzheimer-s-disease-implication-for-the-screening-of-cognitive-frailty
#15
REVIEW
Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Zhuowei Yu
Cognitive frailty (CF) overlaps with early neuropathological alterations associated with aging‑related major neurocognitive disorders, including Alzheimer's disease (AD). Fluid biomarkers for these pathological brain alterations allow for early diagnosis in the preclinical stages of AD, and for objective prognostic assessments in clinical intervention trials. These biomarkers may also be helpful in the screening of CF. The present study reviewed the literature and identified systematic reviews of cohort studies and other authoritative reports...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27499306/impact-of-cognitive-frailty-on-daily-activities-in-older-persons
#16
H Shimada, H Makizako, S Lee, T Doi, S Lee, K Tsutsumimoto, K Harada, R Hotta, S Bae, S Nakakubo, K Harada, T Suzuki
OBJECTIVES: To identify the relationships between physical and/or cognitive frailty and instrumental activities of daily living (IADL) functioning in community living older persons. DESIGN: Cross sectional observation study. SETTING: Data extracted from the 2011-2013 of the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes (NCGG-SGS) database. PARTICIPANTS: A total of 8,864 older adults aged ≥ 65 years who were enrolled in the NCGG-SGS...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27282417/cognitive-impairment-improves-the-predictive-validity-of-physical-frailty-for-mortality-in-patients-with-advanced-heart-failure-referred-for-heart-transplantation
#17
Sunita R Jha, Malin K Hannu, Keren Gore, Sungwon Chang, Phillip Newton, Kay Wilhelm, Christopher S Hayward, Andrew Jabbour, Eugene Kotlyar, Anne Keogh, Kumud Dhital, Emily Granger, Paul Jansz, Phillip M Spratt, Elyn Montgomery, Michelle Harkess, Peta Tunicliff, Patricia M Davidson, Peter S Macdonald
BACKGROUND: The aim of this study was to identify whether the addition of cognitive impairment, depression, or both, to the assessment of physical frailty provides better outcome prediction in patients with advanced heart failure referred for heart transplantation (HT). METHODS: Beginning in March 2013, all patients with advanced heart failure referred to our Transplant Unit have undergone a physical frailty assessment using the Fried frailty phenotype. Cognition was assessed with the Montreal Cognitive Assessment and depression with the Depression in Medical Illness questionnaire...
September 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27092934/the-treviso-dementia-tredem-study-a-biomedical-neuroradiological-neuropsychological-and-social-investigation-of-dementia-in-north-eastern-italy
#18
M Gallucci, E Mariotti, D Saraggi, T Stecca, M G Oddo, C Bergamelli, P Boldrini, S Mazzuco, F Ongaro, P Mecocci, F Di Paola, M Bendini, G L Forloni, D Albani, P Antuono, L Caberlotto, A Zanardo, M Siculi, G B Gajo, E Durante, G Buscato
BACKGROUND: The incidence of dementia increases exponentially with age but knowledge of real disease-modifying interventions is still limited. OBJECTIVES: To describe the study design and methods of a large prospective cohort study aimed at exploring the complex underlying relationships existing among cognition, frailty, and health-related events in older persons with cognitive impairment. DESIGN: Prospective cohort study of a representative population of outpatients attending the Treviso Cognitive Impairment Center between 2000 and 2010...
2012: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27049899/editorial-the-complex-construct-of-mild-cognitive-impairment-be-aware-of-cognitive-frailty
#19
M Canevelli, E Kelaiditi
No abstract text is available yet for this article.
2014: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27013397/physical-frailty-cognitive-impairment-and-the-risk-of-neurocognitive-disorder-in-the-singapore-longitudinal-ageing-studies
#20
Liang Feng, Ma Shwe Zin Nyunt, Qi Gao, Lei Feng, Tih Shih Lee, Tung Tsoi, Mei Sian Chong, Wee Shiong Lim, Simon Collinson, Philip Yap, Keng Bee Yap, Tze Pin Ng
Background: The independent and combined effects of physical and cognitive domains of frailty in predicting the development of mild cognitive impairment (MCI) or dementia are not firmly established. Methods: This study included cross-sectional and longitudinal analyses of physical frailty (Cardiovascular Health Study criteria), cognitive impairment (Mini-Mental State Examination [MMSE]), and neurocognitive disorder (DSM-5 criteria) among 1,575 community-living Chinese older adults from the Singapore Longitudinal Ageing Studies...
March 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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