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https://www.readbyqxmd.com/read/29666146/identification-of-circadian-clock-modulators-from-existing-drugs
#1
T Katherine Tamai, Yusuke Nakane, Wataru Ota, Akane Kobayashi, Masateru Ishiguro, Naoya Kadofusa, Keisuke Ikegami, Kazuhiro Yagita, Yasufumi Shigeyoshi, Masaki Sudo, Taeko Nishiwaki-Ohkawa, Ayato Sato, Takashi Yoshimura
Chronic circadian disruption due to shift work or frequent travel across time zones leads to jet-lag and an increased risk of diabetes, cardiovascular disease, and cancer. The development of new pharmaceuticals to treat circadian disorders, however, is costly and hugely time-consuming. We therefore performed a high-throughput chemical screen of existing drugs for circadian clock modulators in human U2OS cells, with the aim of repurposing known bioactive compounds. Approximately 5% of the drugs screened altered circadian period, including the period-shortening compound dehydroepiandrosterone (DHEA; also known as prasterone)...
April 17, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29658812/late-chronotype-and-high-social-jetlag-are-associated-with-burnout-in-evening-shift-workers-assessment-using-the-chinese-version-mctq-shift
#2
Wan-Ju Cheng, Liang-Wen Hang
Chronotypes are associated with shift work tolerance and sleep in shift workers, and sleep mediates the impact of shift work on mental health. However, the role of chronotype in the association between shift work and mental health has not been clarified. In this study, we aimed to examine the association between chronotype and burnout in shift workers, using the validated Munich ChronoType Questionnaire for shift workers (MCTQshift ). A total of 288 shift workers with irregular shift frequencies were recruited and completed the Chinese-version MCTQshift and the Morningness-Eveningness Questionnaire (MEQ)...
April 16, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29658425/work-and-female-breast-cancer-the-state-of-the-evidence-2002-2017
#3
Connie L Engel, M Sharima Rasanayagam, Janet M Gray, Jeanne Rizzo
The authors undertook a scoping review to assess the literature from 2002 to 2017 on the relationship between occupation and female breast cancer. Case-control, cohort, and meta-analytic studies suggest that women working as flight attendants, in medical professions, some production positions, sales and retail, and scientific technical staff are likely to have elevated risk of breast cancer. In addition, occupational exposures to night-shift work, ionizing radiation, some chemicals, job stress, and sedentary work may increase risk of breast cancer...
May 2018: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/29643924/the-relationship-between-shift-work-and-framingham-risk-score-a-five-year-prospective-cohort-study
#4
Fatemeh Bazyar, Mohammad Gholami-Fesharaki, Mohsen Rowzati
BACKGROUND: There is a small number of studies that considered the relationship between shift work (SW) and Framingham risk score (FRS). This study prospectively examined the association between SW and FRS among man workers based on the multilevel modeling approach. METHODS: This five-year prospective cohort study was done among workers (using stratified random sampling) who work in Esfahan's Mobarakeh Steel Company (EMSC), Iran, from March 2011 to February 2015...
November 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29629067/a-prospective-study-of-psychomotor-performance-of-driving-among-two-kinds-of-shift-work-in-iran
#5
Soheil Saadat, Mojgan Karbakhsh, Mahnaz Saremi, Iraj Alimohammadi, Hassan Ashayeri, Mahsa Fayaz, Farideh Sadeghian, Reza Rostami
Background and aim: Driving after a night shift imposes a risk on health care professionals and other road users. The aim of this study was to measure psychomotor performance of driving of night shift nurses compared to day-shift nurses. Methods: Forty-seven volunteer female nurses working at Sina hospital in Tehran, Iran, with a call in all departments of hospital, participated in this study (23 night shift and 24 day shift nurses) in 2016. The tests included RT for simple reaction time, ATAVT for perceptual speed, LVT for visual orientation and ZBA for time anticipation...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29628308/cracking-the-dna-code-for-v-d-j-recombination
#6
Min-Sung Kim, Watchalee Chuenchor, Xuemin Chen, Yanxiang Cui, Xing Zhang, Z Hong Zhou, Martin Gellert, Wei Yang
To initiate V(D)J recombination for generating the adaptive immune response of vertebrates, RAG1/2 recombinase cleaves DNA at a pair of recombination signal sequences, the 12- and 23-RSS. We have determined crystal and cryo-EM structures of RAG1/2 with DNA in the pre-reaction and hairpin-forming complexes up to 2.75 Å resolution. Both protein and DNA exhibit structural plasticity and undergo dramatic conformational changes. Coding-flank DNAs extensively rotate, shift, and deform for nicking and hairpin formation...
March 29, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29626703/work-schedule-flexibility-is-associated-with-emotional-exhaustion-among-registered-nurses-in-swiss-hospitals-a-cross-sectional-study
#7
Suzanne R Dhaini, Kris Denhaerynck, Stefanie Bachnick, René Schwendimann, Maria Schubert, Sabina De Geest, Michael Simon
BACKGROUND: Emotional exhaustion among healthcare workers is a widely investigated, well-recognized problem, the incidence of which has recently been linked to work environment factors, particularly work/family conflict. However, another environmental feature that may be equally influential, but that is more amenable to nurse manager action, remains less recognized: shift schedule flexibility. OBJECTIVES: This study's main purposes were to assess variations in work schedule flexibility between Swiss acute care hospital units, and to investigate associations between psychosocial work environment (e...
March 27, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29618910/shift-work-and-quality-of-personal-professional-and-family-life-among-health-care-workers-in-a-rehabilitation-center-in-greece
#8
Georgia I Skoufi, Georgios A Lialios, Styliani Papakosta, Theodoros C Constantinidis, Petros Galanis, Evangelia Nena
Context: Adverse work schedules and conditions may affect the physical, mental, and social wellbeing of workers, impairing quality of life and causing conflict between family and work roles. Aims: To compare quality of life, professional quality of life (ProQOL), and work/family conflict (WFC) between shift workers and nonshift workers and explore possible associations with demographic characteristics. Settings and Design: : A cross-sectional study was conducted in a rehabilitation center in Central Greece, recording demographic, occupational, and family characteristics...
September 2017: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29615787/serum-brain-derived-neurotrophic-factor-predicting-reduction-in-pulse-pressure-after-a-one-hour-rest-in-nurses-working-night-shifts
#9
I-Te Lee, Wayne Huey-Herng Sheu, Wen-Jane Lee, Der-Yuan Chen
Night shift work is associated with cardiovascular disease and central nervous system disorders in female nurses. Brain-derived neurotrophic factor (BDNF) exerts protective effects on neural and endothelial functions. This study examined the association between serum BDNF levels and pulse pressure after rest in female nurses working night shifts. In this study, blood samples were collected for BDNF measurement after a night shift when nurses had been working night shifts for three continuous weeks. Blood pressure was assessed before and after a one-hour morning rest within a week of resuming the night shift after one month without any night shift work...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29599751/circadian-rhythms-and-clock-genes-in-reproduction-insights-from-behavior-and-the-female-rabbit-s-brain
#10
REVIEW
Mario Caba, Gabriela González-Mariscal, Enrique Meza
Clock gene oscillations are necessary for a successful pregnancy and parturition, but little is known about their function during lactation, a period demanding from the mother multiple physiological and behavioral adaptations to fulfill the requirements of the offspring. First, we will focus on circadian rhythms and clock genes in reproductive tissues mainly in rodents. Disruption of circadian rhythms or proper rhythmic oscillations of clock genes provoke reproductive problems, as found in clock gene knockout mice...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29593172/interleukin-6-level-among-shift-and-night-workers-in-japan-cross-sectional-analysis-of-the-j-hope-study
#11
Hoichi Amano, Yoshiharu Fukuda, Takashi Yokoo, Kazue Yamaoka
AIM: Shift workers have a high risk of cardiovascular disease (CVD). Systemic inflammation measured has been associated with the risk of CVD onset, in addition to classical risk factors. However, the association between work schedule and inflammatory cytokine levels remains unclear. The purpose of this study was to examine the association between work schedule and interleukin-6 (IL-6)/high-sensitivity C-reactive protein (hs-CRP) levels among Japanese workers. METHODS: The present cross-sectional study was a part of the Japanese Study of Health, Occupation and Psychosocial Factors Related Equity (J-HOPE)...
March 27, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29589871/temporal-dynamics-of-circadian-phase-shifting-response-to-consecutive-night-shifts-in-healthcare-workers-role-of-light-dark-exposure
#12
Julia E Stone, Tracey L Sletten, Michelle Magee, Saranea Ganesan, Megan D Mulhall, Allison Collins, Mark Howard, Steven W Lockley, Shantha M W Rajaratnam
Night shift workers show highly variable rates of circadian adaptation. This study examined the relationship between light exposure patterns and magnitude of circadian phase resetting in response to night shift work. In 21 participants (nursing and medical staff in an Intensive Care Unit [ICU]) circadian phase was measured using 6-sulphatoxymelatonin (aMT6s) at baseline (day/evening shifts of days off) and after 3 to 4 consecutive night shifts. Daily light exposure was examined relative to individual circadian phase to quantify light intensity in the phase delay and phase advance portions of the light phase response curve (PRC)...
March 28, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29589038/shift-work-and-cardiovascular-disease-do-the-new-studies-add-to-our-knowledge
#13
EDITORIAL
Mikko Härmä, Per Gustavsson, Henrik A Kolstad
No abstract text is available yet for this article.
March 28, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29579144/gender-and-ageing-at-work-in-chile-employment-working-conditions-work-life-balance-and-health-of-men-and-women-in-an-ageing-workforce
#14
Alejandra Vives, Nora Gray, Francisca González, Agustín Molina
Objectives: In Chile, working after retirement age has grown substantially over the last years. This, in addition to the country's current discussion about extending retirement age, motivates the need of generating evidence on the occupational health and safety of the working old, with a special focus on women, who are critically disadvantaged in Chile's labour market. The objective of this paper is to describe and compare the ageing workforce of women and men in Chile in terms of labour market participation, employment and working conditions, work-life balance, and health...
March 22, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29567113/perception-of-the-quality-of-care-work-environment-and-sleep-characteristics-of-nurses-working-in-the-national-health-system
#15
María Teresa Moreno-Casbas, Emma Alonso-Poncelas, Teresa Gómez-García, María José Martínez-Madrid, Gema Escobar-Aguilar
OBJECTIVE: To describe nurses' perception in relation to the quality of care and their work environment, as well as to describe their quality of sleep. To analyze the relationship between ward and work shift with nurses' perception of their work environment, sleep quality and day time drowsiness. METHODS: A multicentre, observational and descriptive study carried out between 2012-2014 in seven hospitals of the Spanish National Health System. Work environment, work satisfaction, sleep quality and quality of patient care were evaluated through validated tools...
March 19, 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29566862/male-sleep-duration-and-fecundability-in-a-north-american-preconception-cohort-study
#16
Lauren Anne Wise, Kenneth Jay Rothman, Amelia Kent Wesselink, Ellen Margrethe Mikkelsen, Henrik Toft Sorensen, Craig James McKinnon, Elizabeth Elliott Hatch
OBJECTIVE: To evaluate prospectively the association between male sleep duration and fecundability. DESIGN: Pregnancy Online Study (PRESTO), a Web-based prospective cohort study of North American couples enrolled during the preconception period (2013-2017). SETTING: Not applicable. PATIENT(S): Male participants were aged ≥21 years; female participants were aged 21-45 years. INTERVENTION(S): None...
March 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29563031/gynaecological-cancer-and-night-shift-work-a-systematic-review
#17
REVIEW
Christine Schwarz, Ana María Pedraza-Flechas, Virginia Lope, Roberto Pastor-Barriuso, Marina Pollan, Beatriz Perez-Gomez
Night shift work can affect hormonal balance, and so might be a risk factor for gynaecological malignancies. This report presents a systematic review on the association between this occupational exposure and the incidence of gynaecological cancers other than breast cancer. We searched for original articles addressing this issue in PubMed/MEDLINE, EMBASE and Web of Science, and used the Newcastle-Ottawa Quality Index to evaluate the methodological quality of those reports selected for review. Globally, we found only six articles, which provided the results of just six research studies: four examined ovarian cancer, two endometrial tumours and two cervical cancer...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29561181/effects-of-night-shift-on-the-cognitive-load-of-physicians-and-urinary-steroid-hormone-profiles-a-randomized-crossover-trial
#18
Wolf Osterode, Sandra Schranz, Galateja Jordakieva
Mental and physical stress is common in physicians during night shifts. Neurocognitive effects of sleep deprivation as well as alterations in hormonal and metabolic parameters have previously been described. The aim of this crossover study was to evaluate the effects of night-shift work with partial sleep deprivation on steroid hormone excretion and possible associations with mood, sleep characteristics and cognitive functions in physicians. In total, 34 physicians (mean age 42 ± 8.5 years, 76.5% male) from different departments of the General Hospital of Vienna, Austria, were randomly assigned to two conditions: a regular day shift (8 h on duty, condition 1) and a continuous day-night shift (24 h on duty, condition 2)...
March 21, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29557074/common-sleep-psychiatric-and-somatic-problems-according-to-work-schedule-an-internet-survey-in-an-eastern-european-country
#19
Bogdan I Voinescu
PURPOSE: A wide range of health problems was investigated, aiming to identify the presence and severity of a set of self-reported and common sleep, psychiatric, and somatic health problems among working professionals in four different shift schedules (morning, evening, rotating, and day) in several cities in Romania. METHODS: A heterogeneous sample of 488 workers of different professions completed online a battery of tests, namely the Basic Nordic Sleep Questionnaire, the Parasomnia Questionnaire, the Epworth Sleepiness Scale, and the Patient Health Questionnaire, designed to identity symptoms of insomnia, sleepiness, snoring, parasomnia, as well as of depression, anxiety, eating, somatoform, and alcohol use disorders, respectively...
March 19, 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29555001/out-like-a-light-the-effects-of-a-diurnal-husbandry-schedule-on-mouse-sleep-and-behavior
#20
Amy L Robinson-Junker, Bruce F O'hara, Brianna N Gaskill
Sleep disruption in humans, caused by shift work, can be detrimental to physical and behavioral health. Nocturnal laboratory mice may experience a similar disruption caused by human daytime activities, but whether this disruption affects their welfare is unknown. We used 48 mice (CD1, C57BL/6, and BALB/c of both sexes) in a factorial design to test a sleep disruption treatment, in which mice were disturbed by providing routine husbandry at either 1000 or 2200 during a 12:12-h light:dark cycle, with lights on at 0700...
March 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
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