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https://www.readbyqxmd.com/read/29467974/stroke-simulation-improves-acute-stroke-management-a-systems-based-practice-experience
#1
Tapan Mehta, Sara Strauss, Dawn Beland, Gilbert Fortunato, Ilene Staff, Nora Lee
Background : Literature on the effectiveness of simulation-based medical education programs for caring for acute ischemic stroke (AIS) patients is limited. Objective : To improve coordination and door-to-needle (DTN) time for AIS care, we implemented a stroke simulation training program for neurology residents and nursing staff in a comprehensive stroke center. Methods : Acute stroke simulation training was implemented for first-year neurology residents in July 2011...
February 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29464445/night-shift-work-and-breast-cancer-a-pooled-analysis-of-population-based-case-control-studies-with-complete-work-history
#2
Emilie Cordina-Duverger, Florence Menegaux, Alexandru Popa, Sylvia Rabstein, Volker Harth, Beate Pesch, Thomas Brüning, Lin Fritschi, Deborah C Glass, Jane S Heyworth, Thomas C Erren, Gemma Castaño-Vinyals, Kyriaki Papantoniou, Ana Espinosa, Manolis Kogevinas, Anne Grundy, John J Spinelli, Kristan J Aronson, Pascal Guénel
Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a...
February 20, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29463694/desynchrony-between-brain-and-peripheral-clocks-caused-by-ck1%C3%AE-%C3%AE%C2%B5-disruption-in-gaba-neurons-does-not-lead-to-adverse-metabolic-outcomes
#3
Vincent van der Vinne, Steven J Swoap, Thomas J Vajtay, David R Weaver
Circadian disruption as a result of shift work is associated with adverse metabolic consequences. Internal desynchrony between the phase of the suprachiasmatic nuclei (SCN) and peripheral clocks is widely believed to be a major factor contributing to these adverse consequences, but this hypothesis has never been tested directly. A GABAergic Cre driver combined with conditional casein kinase mutations ( Vgat-Cre + CK1δ fl/fl ε fl/+ ) was used to lengthen the endogenous circadian period in GABAergic neurons, including the SCN, but not in peripheral tissues, to create a Discordant mouse model...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29458781/melatonin-and-breast-cancer-evidences-from-preclinical-and-human-studies
#4
REVIEW
Peter Kubatka, Pavol Zubor, Dietrich Busselberg, Taeg Kyu Kwon, Mariusz Adamek, Daniel Petrovic, Radka Opatrilova, Katarina Gazdikova, Martin Caprnda, Luis Rodrigo, Jan Danko, Peter Kruzliak
The breast cancer affects women with high mortality and morbidity worldwide. The risk is highest in the most developed world but also is markedly rising in the developing countries. It is well documented that melatonin has a significant anti-tumor activities demonstrated on various cancer types in a plethora of preclinical studies. In breast cancer, melatonin is capable to disrupt estrogen-dependent cell signaling, resulting in a reduction of estrogen-stimulated cells, moreover, it's obvious neuro-immunomodulatory effect in organism was described...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29458148/untimely-oxidative-stress-in-%C3%AE-cells-leads-to-diabetes-role-of-circadian-clock-in-%C3%AE-cell-function
#5
REVIEW
J Lee, K Ma, M Moulik, V Yechoor
Diabetes results from a loss of β-cell function. With the number of people with diabetes reaching epidemic proportions globally, understanding mechanisms that are contributing to this increasing prevalence is critical. One such factor has been circadian disruption, with shift-work, light pollution, jet-lag, increased screen time, all acting as potential contributory factors. Though circadian disruption has been epidemiologically associated with diabetes and other metabolic disorders for many decades, it is only recently that there has been a better understanding of the underlying molecular mechanisms...
February 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29445504/the-relationship-between-night-work-and-breast-cancer
#6
Hye-Eun Lee, Jongin Lee, Tae-Won Jang, In-Ah Kim, Jungsun Park, Jaechul Song
Background: Since the International Agency for Research on Cancer classified shift work that involves circadian disruption as "probably carcinogenic to humans," there has been growing concern on the relationship between night work and breast cancer. In Korea, about 10-15% of workers are engaged in night-shift work, and breast cancer is one of the most common cancers in women. The purpose of this study was to review epidemiologic evidence on the relationship between night work and breast cancer...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29445188/daily-circadian-misalignment-impairs-human-cognitive-performance-task-dependently
#7
Sarah L Chellappa, Christopher J Morris, Frank A J L Scheer
Shift work increases the risk for human errors, such that drowsiness due to shift work has contributed to major industrial disasters, including Space Shuttle Challenger, Chernobyl and Alaska Oil Spill disasters, with extraordinary socio-economical costs. Overnight operations pose a challenge because our circadian biology inhibits cognitive performance at night. Yet how the circadian system modulates cognition over multiple days under realistic shift work conditions remains to be established. Importantly, because task-specific cognitive brain regions show different 24-h circadian dynamics, we hypothesize that circadian misalignment impacts cognition task-dependently...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444322/physiological-reactions-to-long-term-fishing-in-the-barents-sea
#8
B Netterstrøm, Å M Hansen, D Isaacson, A M Simonsen, P Weihe
Background: Fishing in distant waters for months may induce physiological stress. Aims: To assess the physiological stress reactions in fishermen working for 2-3 months continuously in 6-h shifts on trawlers in the Barents Sea. Methods: The crew of five trawlers fishing in the Barents Sea from January to April 2004 were invited to participate. In the week before and 5-7 days after the trip, the following measures were collected: salivary cortisol four times a day, 24-h urinary cortisol, blood pressure, heart rate, serum cholesterol, serum high-density lipoprotein (HDL-cholesterol), HbA1c (glycosylated haemoglobin) and weight...
February 10, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29444274/shift-work-parental-cardiovascular-disease-and-myocardial-infarction-in-males
#9
J Hermansson, J Hallqvist, B Karlsson, A Knutsson, K Gillander Gådin
Background: Shift work has been associated with an increased risk of cardiovascular disease (CVD). However, there is a need for more studies to determine whether there is an interaction between shift work and other risk factors of CVD, thereby increasing the risk of CVD in shift workers. Aims: To discern whether shift work and parental mortality from myocardial infarction (MI) or sudden cardiac death (SCD) interact to increase the risk of MI in men. Methods: A case-control dataset was used to assess interaction between shift work and parental history of CVD, using death from MI or SCD, or death before age 65, on an additive scale...
February 10, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29440150/night-shift-work-genetic-risk-and-type-2-diabetes-in-the-uk-biobank
#10
Céline Vetter, Hassan S Dashti, Jacqueline M Lane, Simon G Anderson, Eva S Schernhammer, Martin K Rutter, Richa Saxena, Frank A J L Scheer
OBJECTIVE: To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds. RESEARCH DESIGN AND METHODS: In the UK Biobank, we examined associations of current ( N = 272,214) and lifetime ( N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 and 1,191 prevalent cases, respectively). For 180,704 and 44,141 unrelated participants of European ancestry (4,002 and 726 cases, respectively) with genetic data, we assessed whether shift work exposure modified the relationship between a genetic risk score (comprising 110 single-nucleotide polymorphisms) for type 2 diabetes and prevalent diabetes...
February 12, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29434568/restless-legs-syndrome-willis-ekbom-disease-is-prevalent-in-working-nurses-but-seems-not-to-be-associated-with-shift-work-schedules
#11
Siri Waage, Ståle Pallesen, Bente Elisabeth Moen, Bjørn Bjorvatn
Insomnia and excessive sleepiness are among the most commonly reported sleep problems related to shift work. Sleep-related movement disorders have, however, received far less attention in relation to such work schedules. The objective of this study was to investigate the association between different shift work schedules and the prevalence of Restless legs syndrome/Willis-Ekbom disease (RLS/WED) in a large sample of Norwegian nurses. Our hypothesis was that shift working nurses would report higher prevalence of RLS/WED compared to day workers...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29433969/shift-work-is-associated-with-reduced-heart-rate-variability-among-men-but-not-women
#12
Gerben Hulsegge, Nidhi Gupta, Karin I Proper, Natasja van Lobenstein, Wilhelmina IJzelenberg, David M Hallman, Andreas Holtermann, Allard J van der Beek
BACKGROUND: Imbalance in the autonomic nervous system due to a disrupted circadian rhythm may be a cause of shift work-related cardiovascular diseases. OBJECTIVE: We aimed to determine the association between shift work and cardiac autonomic activity in blue-collar workers. METHODS: The study included 665 blue-collar workers aged 18-68 years in different occupations from two Danish cohort studies. Time and frequency domain parameters of heart rate variability (HRV) were measured during sleep using the Actiheart monitor, and used as markers of cardiac autonomic function...
February 9, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29431129/cohort-profile-lifework-a-prospective-cohort-study-on-occupational-and-environmental-risk-factors-and-health-in-the-netherlands
#13
Marije Reedijk, Virissa Lenters, Pauline Slottje, Anouk Pijpe, Petra H Peeters, Joke C Korevaar, Bas Bueno-de-Mesquita, W M Monique Verschuren, Robert A Verheij, Inka Pieterson, Flora E van Leeuwen, Matti A Rookus, Hans Kromhout, Roel C H Vermeulen
PURPOSE: LIFEWORK is a large federated prospective cohort established in the Netherlands to quantify the health effects of occupational and environmental exposures. This cohort is also the Dutch contribution to the international Cohort Study of Mobile Phone Use and Health (COSMOS). In this paper, we describe the study design, ongoing data collection, baseline characteristics of participants and the repeatability of key questionnaire items. PARTICIPANTS: 88 466 participants were enrolled in three cohort studies in 2011-2012...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29420700/the-role-of-sex-gender-health-factors-and-job-context-in-workplace-accommodation-use-among-men-and-women-with-arthritis
#14
Monique A M Gignac, Selahadin Ibrahim, Peter M Smith, Vicki Kristman, Dorcas E Beaton, Cameron A Mustard
Background: With the aging of populations in many countries, workers are expected to remain employed longer but may struggle with the onset of common, chronic conditions like arthritis. To date, few studies have examined workplace policies and practices that could help accommodate individuals with arthritis, and fewer still have used a sex and gender-based approach to explore similarities and differences between women and men. Objectives: This study compared the health and work contexts of workers aged ≥50 years to better understand similarities and differences between women and men in accommodation availability, need, use, and unmet needs...
February 6, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29417483/risk-assessment-of-occupational-exposure-to-benzene-using-numerical-simulation-in-a-complex-geometry-of-a-reforming-unit-of-petroleum-refinery
#15
Majid Bayatian, Khosro Ashrafi, Mansour Rezazadeh Azari, Mohammad Javad Jafari, Yadollah Mehrabi
There has been an increasing concern about the continuous and the sudden release of volatile organic pollutants from petroleum refineries and occupational and environmental exposures. Benzene is one of the most prevalent volatile compounds, and it has been addressed by many authors for its potential toxicity in occupational and environmental settings. Due to the complexities of sampling and analysis of benzene in routine and accidental situations, a reliable estimation of the benzene concentration in the outdoor setting of refinery using a computational fluid dynamics (CFD) could be instrumental for risk assessment of occupational exposure...
February 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29415446/melatonin-a-molecule-for-reducing-breast-cancer-risk
#16
REVIEW
Alicia González-González, María Dolores Mediavilla, Emilio J Sánchez-Barceló
The objective of this article is to review the basis supporting the usefulness of melatonin as an adjuvant therapy for breast cancer (BC) prevention in several groups of individuals at high risk for this disease. Melatonin, as a result of its antiestrogenic and antioxidant properties, as well as its ability to improve the efficacy and reduce the side effects of conventional antiestrogens, could safely be associated with the antiestrogenic drugs presently in use. In individuals at risk of BC due to night shift work, the light-induced inhibition of melatonin secretion, with the consequent loss of its antiestrogenic effects, would be countered by administering this neurohormone...
February 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29410744/sleep-architecture-in-night-shift-workers-police-officers-with-obstructive-sleep-apnea-hypopnea-syndrome
#17
Selene Verde-Tinoco, Rafael Santana-Miranda, Romel Gutiérrez-Escobar, Reyes Haro, Joana Miranda-Ortiz, Talia Berruga-Fernandez, Ulises Jimenez-Correa, Adrián Poblano
Introduction: Reduced sleep to increase work hours is common among police officers, when this situation is combined with Obstructive sleep apnea/hypopnea syndrome (OSAHS), health consequences are greater, therefore we believe there is a need of research for these alterations. The aim of this study was to measure the changes in sleep architecture (SA) in police officers who currently have Night shift work (NSW) and OSAHS. Methods: We compared SA in 107 subjects divided in three groups: the first group included police officers with NSW and severe OSAHS (n = 48); the second group were non-police officers with diurnal work time and severe OSAHS (n = 48) and the third group was formed by healthy controls (n = 11)...
October 2017: Sleep Science
https://www.readbyqxmd.com/read/29409501/development-and-psychometric-evaluation-of-a-women-shift-workers-reproductive-health-questionnaire-study-protocol-for-a-sequential-exploratory-mixed-method-study
#18
Maryam Nikpour, Aram Tirgar, Abbas Ebadi, Fatemeh Ghaffari, Mojgan Firouzbakht, Mahmod Hajiahmadi
BACKGROUND: Although shift works is a certain treat for female reproductive health, but currently, there is no standardized instrument for measuring reproductive health among female shift workers. This study aims to develop and evaluate the psychometric properties of a Women Shift Workers' Reproductive Health Questionnaire (WSW-RHQ). METHODS: This is a sequential exploratory mixed-method study with a qualitative and a quantitative phase. In the qualitative phase, semi-structured interviews will be held with female shift workers who live in Mazandaran Province, Iran, additionally, the literature review will be performed by searching electronic databases...
February 6, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29408974/the-impact-of-sleep-disorders-on-driving-safety-findings-from-the-shrp-2-naturalistic-driving-study
#19
Shu-Yuan Liu, Miguel A Perez, Nathan Lau
Study Objectives: This study investigated the association between driving safety and seven sleep disorders amongst 3,541 participants of the Second Strategic Highway Research Program (SHRP 2) naturalistic driving study. Methods: SHRP 2 collected naturalistic driving data from participants between 16 to 98 years old by instrumenting participants' vehicles. The analyses used logistic regression to determine the likelihood of crash/near-crash involvement, Poisson log-linear regression to assess crash/near-crash rate, and ordinal logistic regression to assess driver maneuver appropriateness and crash/near-crash severity...
February 2, 2018: Sleep
https://www.readbyqxmd.com/read/29405095/shift-work-cycle-induced-alterations-of-circadian-rhythms-potentiate-the-effects-of-high-fat-diet-on-inflammation-and-metabolism
#20
Sam-Moon Kim, Nichole Neuendorff, Robert C Alaniz, Yuxiang Sun, Robert S Chapkin, David J Earnest
Based on genetic models with mutation or deletion of core clock genes, circadian disruption has been implicated in the pathophysiology of metabolic disorders. Thus, we examined whether circadian desynchronization in response to shift work-type schedules is sufficient to compromise metabolic homeostasis and whether inflammatory mediators provide a key link in the mechanism by which alterations of circadian timekeeping contribute to diet-induced metabolic dysregulation. In high-fat diet (HFD)-fed mice, exposure to chronic shifts of the light-dark cycle (12 h advance every 5 d): 1) disrupts photoentrainment of circadian behavior and modulates the period of spleen and macrophage clock gene rhythms; 2) potentiates HFD-induced adipose tissue infiltration and activation of proinflammatory M1 macrophages; 3) amplifies macrophage proinflammatory cytokine expression in adipose tissue and bone marrow-derived macrophages; and 4) exacerbates diet-induced increases in body weight, insulin resistance, and glucose intolerance in the absence of changes in total daily food intake...
February 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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