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JOURNAL ARTICLE
Aza B Taha
INTRODUCTION: Urinary tract infection (UTI) is a common bacterial complication in pregnancy. The study aimed to estimate the prevalence, risk factors, and bacterial etiology of UTI during pregnancy and determine the efficacy of antimicrobial drugs in treating UTIs. METHODOLOGY: Urine specimens and clinical data were collected from pregnant women who attended primary health centers in Erbil, Iraq. All specimens were cultured on appropriate media and identified by standard microbiological methods...
March 31, 2024: Journal of Infection in Developing Countries
#2
JOURNAL ARTICLE
Kathryn A W Knight, Catriona Barbour-Hastie, Angus Gane, Jonathan O'Riordan
A man in his 30s was referred to neurology with right-sided paraesthesia, tremors, chest pain and lower urinary tract and erectile dysfunction. He had a medical history of left acetabular dysplasia, and subjective memory impairment, the latter being in the context of depression and chronic pain with opioid use. There was no notable family history. On examination, he had a spastic paraparesis. Imaging revealed atrophy of the thoracic spine. Lumbar puncture demonstrated a raised protein but other constituents were normal, including no presence of oligoclonal bands...
April 17, 2024: BMJ Case Reports
#3
JOURNAL ARTICLE
Jessica S Hurwitz, Mae Newton-Foot, Kristien Nel van Zyl, Pieter Nel
BACKGROUND: Fosfomycin treatment of urinary tract infections is increasingly attractive due to escalating antibiotic resistance rates among urinary pathogens. Standard antibiotic susceptibility testing methods perform poorly for fosfomycin as there is poor correlation between susceptibility results and clinical outcomes in urinary pathogens other than Escherichia coli . OBJECTIVE: We evaluated the performance of fosfomycin susceptibility testing in E. coli and Klebsiella pneumoniae to determine whether fosfomycin susceptibility is associated with molecular resistance mechanisms...
2024: African Journal of Laboratory Medicine
#4
JOURNAL ARTICLE
Wei Zhang, Yufei Wang, Kaiying Wang, Jinhui Li, Jia Liu, Shulei Li, Lijie Song, Chunchen Liao, Xiaoli Yang, Peng Li, Xiong Liu
BACKGROUND: Urinary tract infection (UTI) associated with Klebsiella pneumoniae poses a serious threat for inpatients. This study aimed to describe the genomic characteristics of K. pneumoniae causing UTI in a tertiary-care hospital in Beijing, China. METHODS: A total of 20 K. pneumoniae strains collected from 2020 to 2021 were performed whole-genome sequencing. The Antibiotic susceptibility of 19 common antimicrobial agents was tested against all strains. The multi-locus sequence types (MLSTs) and serotypes were determined from the WGS data...
2024: Infection and Drug Resistance
#5
JOURNAL ARTICLE
Yuanjie Lv, Xiaoping Liu
JC polyomavirus (JCPyV) is a human polyomavirus that can establish lifelong persistent infection in the majority of adults. It is typically asymptomatic in immunocompetent individuals. However, there is a risk of developing progressive multifocal leukoencephalopathy (PML) in immunocompromised or immunosuppressed patients. Though JCPyV commonly resides in the kidney-urinary tract, its involvement in urinary system diseases is extremely rare. Here, we reported a case of a 60-year-old male patient with coronavirus disease 2019 (COVID-19) infection who developed hemorrhagic cystitis after receiving treatment with nirmatrelvir 300 mg/ritonavir 100 mg quaque die (QD)...
April 16, 2024: BMC Urology
#6
JOURNAL ARTICLE
Samantha Henry, Steven Macauley Lewis, Samantha Leeanne Cyrill, Mackenzie Kate Callaway, Deeptiman Chatterjee, Amritha Varshini Hanasoge Somasundara, Gina Jones, Xue-Yan He, Giuseppina Caligiuri, Michael Francis Ciccone, Isabella Andrea Diaz, Amelia Aumalika Biswas, Evelyn Hernandez, Taehoon Ha, John Erby Wilkinson, Mikala Egeblad, David Arthur Tuveson, Camila Oresco Dos Santos
Exposure to pathogens throughout a lifetime influences immunity and organ function. Here, we explore how the systemic host-response to bacterial urinary tract infection (UTI) induces tissue-specific alterations to the mammary gland. Utilizing a combination of histological tissue analysis, single cell transcriptomics, and flow cytometry, we identify that mammary tissue from UTI-bearing mice displays collagen deposition, enlarged ductal structures, ductal hyperplasia with atypical epithelial transcriptomes and altered immune composition...
April 16, 2024: Nature Communications
#7
JOURNAL ARTICLE
Weibing Pan, Tianwei Yun, Xin Ouyang, Zhijun Ruan, Tuanjie Zhang, Yuhao An, Rui Wang, Peng Zhu
Kidney stone disease (KSD, also named renal calculi, nephrolithiasis, or urolithiasis) is a common urological disease entailing the formation of minerals and salts that form inside the urinary tract, frequently caused by diabetes, high blood pressure, hypertension, and monogenetic components in most patients. 10% of adults worldwide are affected by KSD, which continues to be highly prevalent and with increasing incidence. For the identification of novel therapeutic targets in KSD, we adopted high-throughput sequencing and mass spectrometry (MS) techniques in this study and carried out an integrative analysis of exosome proteomic data and DNA methylation data from blood samples of normal and KSD individuals...
April 16, 2024: Molecular Omics
#8
JOURNAL ARTICLE
Julia Shinnick, Isabel Josephs, Johanna A Suskin, Kathryn Kurchena, Lindsey Pileika, Spencer Darveau, Matthew M Scarpaci, Cassandra Carberry
IMPORTANCE: Little evidence is available to inform management of acute urinary tract infections (UTIs) in women with recurrent urinary tract infection (rUTI). OBJECTIVE: This study aimed to compare the proportion of acute UTIs with persistence/relapse or recurrence based on duration of treatment antibiotics (acute UTI guideline-consistent versus extended). STUDY DESIGN: A retrospective noninferiority study of women with rUTI was performed at an academic tertiary referral center from January 2016 to December 2020...
March 27, 2024: Urogynecology (Phila)
#9
JOURNAL ARTICLE
Alireza Mohammadzadeh, Hamid Naghizadeh, Ahmad Mosadegh, Akram Astani, Omid Pouresmaeil, Jalal Mardaneh
BACKGROUND: Urinary tract infection (UTI) is one of the common bacterial infections. Escherichia coli is the most common cause of UTI. In this research, the prevalence of several virulence factors and beta-lactam resistance genes was investigated. METHODS: One hundred E. coli isolates were collected from patients' specimens with UTI referred to Allame-Bohlol Gonabadi hospital. Polymerase chain reaction (PCR) was performed to identify five pathogenic genes ( fimH, aer, pap, hly, traT ) and three antibiotic resistance genes ( blaTEM, blaCTX, blaSHV )...
October 2023: Reports of Biochemistry & Molecular Biology
#10
JOURNAL ARTICLE
Tetsuya Ito, Tatsuro Yamaguchi, Kensuke Kumamoto, Okihide Suzuki, Noriyasu Chika, Satoru Kawakami, Tomonori Nagai, Tsukasa Igawa, Kenji Fujiyoshi, Yoshito Akagi, Tomio Arai, Kiwamu Akagi, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida
BACKGROUND: Based on molecular characteristics, deficient DNA mismatch repair (dMMR) solid tumors are largely divided into three categories: somatically MLH1-hypermethylated tumors, Lynch syndrome (LS)-associated tumors, and Lynch-like syndrome (LLS)-associated tumors. The incidence of each of these conditions and the corresponding pathogenic genes related to LLS remain elusive. METHODS: We identified dMMR tumors in 3609 tumors from 9 different solid organs, including colorectal cancer, gastric cancer, small-bowel cancer, endometrial cancer, ovarian cancer, upper urinary tract cancer, urinary bladder cancer, prostate cancer, and sebaceous tumor, and comprehensively summarized the characterization of dMMR tumors...
April 14, 2024: International Journal of Clinical Oncology
#11
JOURNAL ARTICLE
Barbara Cellini
PURPOSE OF REVIEW: Primary hyperoxalurias (PHs) are rare disorders caused by the deficit of liver enzymes involved in glyoxylate metabolism. Their main hallmark is the increased excretion of oxalate leading to the deposition of calcium oxalate stones in the urinary tract. This review describes the molecular aspects of PHs and their relevance for the clinical management of patients. RECENT FINDINGS: Recently, the study of PHs pathogenesis has received great attention...
April 12, 2024: Current Opinion in Nephrology and Hypertension
#12
JOURNAL ARTICLE
Adeliia Giliazeva, Yaw Akosah, Jonas Noack, Ayslu Mardanova
The intestinal and respiratory tracts of healthy individuals serve as habitats for a diverse array of microorganisms, among which Klebsiella oxytoca holds significance as a causative agent in numerous community- and hospital-acquired infections, often manifesting in polymicrobial contexts. In specific circumstances, K. oxytoca, alongside other constituents of the gut microbiota, undergoes translocation to distinct physiological niches. In these new environments, it engages in close interactions with other microbial community members...
April 8, 2024: Microbial Pathogenesis
#13
REVIEW
Maike Büttner-Herold, Kerstin Amann, Joachim Velden
Infections can affect the kidney via different pathways. Urinary tract infections can directly involve the renal tissue by spreading along pre-existing canalicular structures. Such an ascending infection can manifest as a highly active and purulent or even abscessing interstitial nephritis or as a chronic-fibrosing process in recurrent pyelonephritis. Viral infections can also use the canalicular route as in polyomavirus nephropathy or spread via the blood stream in a hematogenous manner as in the case of cytomegalovirus or hantavirus infections...
April 10, 2024: Pathologie (Heidelb)
#14
REVIEW
Andrew S Bray, M Ammar Zafar
Bacterial infections pose a significant global health threat, accounting for an estimated 7.7 million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably Klebsiella pneumoniae ( K. pneumoniae ), are of grave concern. This opportunistic pathogen causes pneumonia, urinary tract infections, and bacteremia, particularly in immunocompromised individuals. The rise of hypervirulent K. pneumoniae adds complexity, as it increasingly infects healthy individuals. Recent epidemiological data suggest that asymptomatic gastrointestinal carriage serves as a reservoir for infections in the same individual and allows for host-to-host transmission via the fecal-oral route...
April 10, 2024: Infection and Immunity
#15
REVIEW
Unitary Tract Infection Treatment: When to Use What Agents including Beta-lactam Combination Agents.
Arsheena Yassin, Keith S Kaye, Tanaya Bhowmick
In this study, the authors review antibiotic treatment options for both acute uncomplicated and complicated urinary tract infection (UTI). In addition, they also review regimens used in the setting of drug-resistant pathogens including vancomycin resistant Enterococcus, extended spectrum beta-lactamase (ESBL) producing Enterobacterals, carbapenem-resistant Enterobacterals and carbapenem-resistant Pseudomonas, which are encountered with increasing frequency.
April 8, 2024: Infectious Disease Clinics of North America
#16
JOURNAL ARTICLE
Yuvarajan Subramaniyan, Altaf Khan, M Mujeeburahiman, Punchappady Devasya Rekha
Urological diseases affect all age groups and are associated with different urinary complications. Presence of pathogenic bacteria complicates the urological diseases such as chronic kidney disease (CKD), kidney stone disease (KSD), emphysematous pyelonephritis (EPN), and urological cancers (UCs) coinciding with urinary metabolic complications. The One Health concept for preventing the spread of antibiotic resistant opportunistic pathogens necessitates detailed investigation on the virulence and the antibiotic sensitivity patterns of the pathogens from the urinary tract infections (UTIs)...
April 8, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
#17
JOURNAL ARTICLE
Yikun Xing, Justin R Clark, James D Chang, Jacob J Zulk, Dylan M Chirman, Felipe-Andres Piedra, Ellen E Vaughan, Haroldo J Hernandez Santos, Kathryn A Patras, Anthony W Maresso
Extraintestinal pathogenic Escherichia coli (ExPEC) is a leading cause of worldwide morbidity and mortality, the top cause of antimicrobial-resistant (AMR) infections, and the most frequent cause of life-threatening sepsis and urinary tract infections (UTI) in adults. The development of an effective and universal vaccine is complicated by this pathogen's pan-genome, its ability to mix and match virulence factors and AMR genes via horizontal gene transfer, an inability to decipher commensal from pathogens, and its intimate association and co-evolution with mammals...
April 9, 2024: Infection and Immunity
#18
JOURNAL ARTICLE
J M Sahuquillo-Arce, P Suárez-Urquiza, A Hernández-Cabezas, L Tofan, R Chouman-Arcas, M García-Hita, O Sabalza-Baztán, A Sellés-Sánchez, N Lozano-Rodríguez, J Martí-Cuñat, J L López-Hontangas
Actinotignum schaalii affects elderly people and is associated with individuals with urological-related predispositions, but can be found in a variety of locations, such as cutaneous, intraabdominal, genitourinary and surgical infections. Disseminated infections occur less frequently and are by and large related to urinary tract colonisation. This pathogen is often neglected due to growth requirements, especially in urinary tract infections. We present 107 Actinotignum schaalii isolated from genitourinary samples (80...
April 15, 2024: Heliyon
#19
JOURNAL ARTICLE
Kanao Kobayashi, Satoshi Takahashi, Mitsuru Yasuda, Jun Miyazaki, Koichiro Wada, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Naoki Hasegawa, Intetsu Kobayashi, Naoya Masumori, Takahiro Kimura, Hiroki Yamada, Tohru Nakagawa, Tomoyuki Kaneko, Kazumasa Matsumoto, Tetsuya Fujimura, Jun Kamei, Kiyohito Ishikawa, Kiyohide Fujimoto, Yasushi Nakai, Katsumi Shigemura, Takuya Sadahira, Nobuyuki Hinata, Hiroyuki Kitano, Masuo Yamashita, Tomihiko Yasufuku, Hisao Komeda, Yoshiki Hiyama, Yoshito Takahashi, Sojun Kanamaru, Masaya Murakami, Soichi Arakawa, Daisuke Yamada, Koji Mita, Ryoichi Hamasuna, Kazushi Tanaka, Masanori Matsukawa, Eiichiro Takaoka, Masanobu Shigeta, Tadasu Takenaka, Masashi Nishino, Satoshi Ishitoya, Shohei Hayakawa, Kazuhiro Okumura, Masakatsu Ueda
INTRODUCTION: Antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using the national surveillance data, comprising 793 bacterial strains from eight clinically relevant species. MATERIALS AND METHODS: Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology...
April 6, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#20
Rajesh Dudani, Amani Qasem, Kingsley Udom
Aerococcus urinae ( A. urinae ) infection, primarily observed in elderly patients, is a rare yet emerging occurrence in the pediatric population. Advances in laboratory techniques have facilitated the increased identification of these bacteria in human infections. There have been only a few recent cases reported among children. The scarcity of literature on the clinical presentation and management of such infections in children presents a challenge for pediatricians. Here, we present the case of a 15-month-old male child with Down syndrome who presented with malodorous urine but lacked other typical symptoms of urinary tract infection...
March 2024: Curēus
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