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urinary tract pathogens

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https://www.readbyqxmd.com/read/28211358/a-prospective-interventional-study-to-examine-the-effect-of-a-silver-alloy-and-hydrogel-coated-catheter-on-the-incidence-of-catheter-associated-urinary-tract-infection
#1
P Hy Chung, C Wy Wong, C Kc Lai, H K Siu, D Nc Tsang, K Y Yeung, D Km Ip, P Kh Tam
INTRODUCTION: Catheter-associated urinary tract infection is a major hospital-acquired infection. This study aimed to analyse the effect of a silver alloy and hydrogel-coated catheter on the occurrence of catheter-associated urinary tract infection. METHODS: This was a 1-year prospective study conducted at a single centre in Hong Kong. Adult patients with an indwelling urinary catheter for longer than 24 hours were recruited. The incidence of catheter-associated urinary tract infection in patients with a conventional latex Foley catheter without hydrogel was compared with that in patients with a silver alloy and hydrogel-coated catheter...
February 17, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28209132/urinary-tract-infection-among-fistula-patients-admitted-at-hamlin-fistula-hospital-addis-ababa-ethiopia
#2
Matifan Dereje, Yimtubezinesh Woldeamanuel, Daneil Asrat, Fekade Ayenachew
BACKGROUND: Urinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Therefore the aim of this study was to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia...
February 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28185626/prevalence-of-concomitant-acute-bacterial-meningitis-in-neonates-with-febrile-urinary-tract-infection-a-retrospective-cross-sectional-study
#3
Sowdhamini S Wallace, Danielle N Brown, Andrea T Cruz
OBJECTIVE: To describe the frequency of concomitant acute bacterial meningitis (ABM) in neonates with febrile urinary tract infection (UTI). STUDY DESIGN: This was a retrospective cross-sectional study from 2005 to 2013 of infants ≤30 days old evaluated in the emergency department of a quaternary care children's hospital with fever and laboratory-confirmed UTI. Definite ABM was defined as cerebrospinal fluid (CSF) culture with growth of pathogenic bacteria and probable ABM if pleocytosis with ≥ 20 white blood cell was present in an antibiotic-pretreated patient...
February 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28176620/epidemiology-of-infectious-complications-in-renal-allograft-recipients-in-the-first-year-after-transplant
#4
Afsane Bahrami, Seyyede Fatemeh Shams, Elham Shaarbaf Eidgahi, Zahra Lotfi, Maryam Sheikhi, Sepideh Shakeri
OBJECTIVES: Renal transplant is one of the best ways to extend life of patients in the end stage of renal disease. Infections are significant causes of morbidity and mortality after renal transplant. The aim of this study was to evaluate frequency, risk factors, causative pathogens, and clinical manifestations in renal transplant recipients from Mashhad City during the first year after transplant. MATERIALS AND METHODS: This research was conducted at Montaserie Hospital of Mashhad University of Medical Sciences from March 2013 to July 2015...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28167542/in-vitro-activity-of-delafloxacin-when-tested-against-contemporary-bacterial-pathogens-from-the-united-states-and-europe-2014
#5
M A Pfaller, H S Sader, P R Rhomberg, R K Flamm
The in vitro activities of delafloxacin and comparator antimicrobial agents were tested against 6,485 bacterial isolates from medical centers in Europe (EU) and the United States (US) in 2014. Delafloxacin was the most potent agent tested against methicillin-susceptible S. aureus (MSSA), MRSA, Streptococcus pneumoniae, viridans group streptococci, and β-hemolytic streptococci and had activity similar to that of ciprofloxacin and levofloxacin against certain members of the Enterobacteriaceae. Overall the broadest coverage of tested pathogens (Gram-positive cocci and Gram-negative bacilli) was observed with meropenem and tigecycline in both EU and US...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167145/the-miia-motif-is-a-common-marker-present-in-polytopic-surface-proteins-of-oral-and-urinary-tract-invasive-bacteria
#6
Antonio J Martín-Galiano
Many surface virulence factors of bacterial pathogens show mosaicism and confounding phylogenetic origin. The Streptococcus gordonii platelet-binding GspB protein, the Streptococcus sanguinis SrpA adhesin and the Streptococcus pneumoniae DiiA protein, share an imperfect 27-residue motif. Given the disparate domain architectures of these proteins and its association to invasive disease, this motif was named MiiA from Multiarchitecture invasion-involved motif A. MiiA is predicted to adopt a beta-sheet folding, probably related to the Ig-like fold, with a symmetrical positioning of two conserved aspartic residues...
February 4, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28154560/detection-of-sgi1-pgi1-elements-and-resistance-to-extended-spectrum-cephalosporins-in-proteae-of-animal-origin-in-france
#7
Eliette Schultz, Axel Cloeckaert, Benoît Doublet, Jean-Yves Madec, Marisa Haenni
Proteae, and especially Proteus mirabilis, are often the cause of urinary tract infections (UTIs) in humans. They were reported as carriers of extended-spectrum β-lactamase (ESBL) genes, and recently of carbapenemases, mostly carried by the Salmonella genomic island 1 (SGI1) and Proteus genomic island 1 (PGI1). Proteae have also lately become an increasing cause of UTIs in companion animals, but antimicrobial susceptibility data in animals are still scarce. Here, we report the characterization of 468 clinical epidemiologically unrelated Proteae strains from animals collected between 2013 and 2015 in France...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28150535/molecular-and-antimicrobial-susceptibility-characterization-of-globicatella-sulfidifaciens-isolated-from-sow-s-urinary-tract-infection
#8
Carlos E C Matajira, Luisa Z Moreno, Vasco T M Gomes, Ana Paula S Silva, Renan E Mesquita, Cristina R Amigo, Ana Paula G Christ, Maria Inês Z Sato, Andrea M Moreno
BACKGROUND: The Globicatella genus comprises Gram-positive, facultative anaerobic, α-hemolytic and catalase negative cocci morphologically and phenotypically very similar to Streptococcus and Aerococcus genus which can lead to misidentification and underestimation of this pathogen. Globicatella species have already been isolated from human and animals with heart and brain disorders. Their clinical relevance in animals, and its zoonotic potential, remains unknown due to the difficulty in their identification...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28146187/-factors-associated-with-extended-spectrum-betalactamases-producing-organisms-among-patients-with-urinary-tract-infections-a-prospective-cohort-study
#9
Cristián Avilés, Pablo Betancour, Carmen Luz Velasco, Rodrigo Godoy, Elizabeth Barthel, Felipe Martínez
BACKGROUND: Urinary tract infections (UTIs) caused by extended-spectrum betalactamases (ESBL) are an increasingly common problem. AIM: To develop an association model to allow an early detection of ESBL-producing microorganisms. METHODS: A prospective observational cohort study was undertaken among patients admitted with a diagnosis of culture-proven UTI to the Internal Medicine Ward of the Hospital Naval Almirante Nef between February and November, 2011...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28135233/use-of-colistin-in-a-neonatal-intensive-care-unit-a-cohort-study-of-65-patients
#10
Eren Çağan, Evrim Kıray Baş, Hüseyin Selim Asker
BACKGROUND The emergence of infections related to multidrug-resistant Gram-negative bacilli (MDR-GNB) reintroduced the use of colistin, an antibiotic that was previously abandoned due to adverse effects. However, because of its limited use in neonatal intensive care units, there is very little data about the effectiveness and safety of colistin in children and newborns. In this study, which will be the largest case study in the literature, we aimed to evaluate the effectiveness and safety of colistin in full-term and preterm newborns...
January 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28129394/characterization-of-early-phase-neutrophil-extracellular-traps-in-urinary-tract-infections
#11
Yanbao Yu, Keehwan Kwon, Tamara Tsitrin, Shiferaw Bekele, Patricia Sikorski, Karen E Nelson, Rembert Pieper
Neutrophils have an important role in the antimicrobial defense and resolution of urinary tract infections (UTIs). Our research suggests that a mechanism known as neutrophil extracellular trap (NET) formation is a defense strategy to combat pathogens that have invaded the urinary tract. A set of human urine specimens with very high neutrophil counts had microscopic evidence of cellular aggregation and lysis. Deoxyribonuclease I (DNase) treatment resulted in disaggregation of such structures, release of DNA fragments and a proteome enriched in histones and azurophilic granule effectors whose quantitative composition was similar to that of previously described in vitro-formed NETs...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28122913/epidemiology-and-susceptibility-of-pathogens-from-smart-2011-12-turkey-evaluation-of-hospital-acquired-versus-community-acquired-urinary-tract-infections-and-icu-versus-non-icu-associated-intra-abdominal-infections
#12
Iftihar Koksal, Gurdal Yilmaz, Serhat Unal, Pinar Zarakolu, Volkan Korten, Lutfiye Mulazimoglu, Fehmi Tabak, Birgul Mete, Vildan Avkan Oguz, Zeynep Gulay, Emine Alp, Robert Badal, Sibylle Lob
OBJECTIVES: To describe the epidemiology and susceptibility of pathogens (including ESBL producers) from hospital-acquired (HA) versus community-acquired (CA) urinary tract infections (UTIs) and ICU- versus non-ICU-associated intra-abdominal infections (IAIs) in Turkey as a part of the SMART study. METHODS: For this report, Gram-negative pathogens (363 from UTIs and 458 from IAIs) were collected in 2011 and 2012 at six hospitals in Turkey. HA versus CA UTIs and ICU- versus non-ICU-associated IAIs were compared for the species isolated, percentage of ESBL-positive isolates by species and susceptibility for overall and individual Gram-negative species...
January 25, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28114875/catheter-associated-urinary-tract-infection-cauti-after-term-cesarean-delivery-incidence-and-risk-factors-at-a-multi-center-academic-institution
#13
Laura J Moulton, Mark Lachiewicz, Xiaobo Liu, Oluwatosin Goje
PURPOSE: To identify the rate of CAUTI (catheter-associated urinary tract infection) after CD (Cesarean delivery) and to determine if any factors increase risk of infection. METHODS: A retrospective cohort study was performed at a multi-center institution for patients who underwent CD in 2013. All patients had urinary catheters inserted before surgery. Diagnosis followed IDSA guidelines with culture growing greater than 10(3) CFU of bacteria per mL with symptoms or symptomatic urinary tract infections treated at provider discretion...
January 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28110918/nitroxoline-a-broad-spectrum-biofilm-eradicating-agent-against-pathogenic-bacteria
#14
Yasmeen Abouelhassan, Qingping Yang, Hussain Yousaf, Minh Thu Nguyen, Melanie Rolfe, Gregory S Schultz, Robert W Huigens
Bacterial biofilms are surface-attached communities of slow-growing or non-replicating bacteria tolerant to conventional antibiotic therapies. Although biofilms are known to occur in ca. 80% of all bacterial infections, no therapeutic agent has been developed to eradicate bacteria housed within biofilms. We have discovered that nitroxoline, an antibacterial agent used to treat urinary tract infections, displays broad-spectrum biofilm-eradicating activities against major human pathogens, including drug-resistant Staphylococcus aureus and Acinetobacter baumannii strains...
December 6, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28105405/a-rare-case-of-perineal-abscess-caused-by-aerococcus-urinae
#15
Lawrence Ha, Negin Niknam, Siddhi Mankame, Robin Koshy
Aerococcus urinae, a previously misidentified pathogen, has become increasingly recognized to cause severe and even fatal infections. Aerococcus-related perineal abscess infections have not previously been reported in the literature. Most reported cases of infections caused by Aerococcus are urinary tract infections, bacteremia, and even rare cases of endocarditis. We report an unusual case of a perineal abscess caused by Aerococcus urinae.
2017: IDCases
https://www.readbyqxmd.com/read/28104655/first-complete-providencia-rettgeri-genome-sequence-the-ndm-1-producing-clinical-strain-rb151
#16
R Alejandro Marquez-Ortiz, Leanne Haggerty, Eby M Sim, Carolina Duarte, Betsy E Castro-Cardozo, Mauricio Beltran, Sandra Saavedra, Natasha Vanegas, Javier Escobar-Perez, Nicola K Petty
Providencia rettgeri is an opportunistic bacterial pathogen of clinical significance due to its association with urinary tract infections and multidrug resistance. Here, we report the first complete genome sequence of P. rettgeri The genome of strain RB151 consists of a 4.8-Mbp chromosome and a 108-kbp blaNDM-1-positive plasmid.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28104383/virulence-traits-and-pathogenicity-of-uropathogenic-escherichia-coli-isolates-with-common-and-uncommon-o-serotypes
#17
Qingqing Gao, Debao Zhang, Zhengqin Ye, Xiaoping Zhu, Weixia Yang, Lanmei Dong, Song Gao, Xiufan Liu
Urinary tract infections (UTIs) are among the most common human diseases worldwide. This study aimed to collect uropathogenic Escherichia coli (UPEC) isolates from Jiangsu Province and obtain insights into the molecular epidemiology of UPEC in this region. The O serotypes, phylogenetic groups, and virulence factors of 183 UPEC isolates were determined. In this study, we isolated 51 UPEC isolates with common O serotypes including O1, O2, O4, O6, O7, O16, O18 and O75, as well as 35 of those with uncommonly encountered O serotypes including O8, O12, O15, O26, and O74...
January 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28102784/model-systems-for-the-study-of-enterococcal-colonization-and-infection
#18
H M Sharon Goh, M H Adeline Yong, Kelvin Kian Long Chong, Kimberly A Kline
Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the urinary tract, catheterized urinary tract, bloodstream, wounds and surgical sites, and heart valves in endocarditis. Enterococcal infections are often biofilm-associated, polymicrobial in nature, and resistant to antibiotics of last resort. Understanding Enterococcal mechanisms of colonization and pathogenesis are important for identifying new ways to manage and intervene with these infections...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28101682/synthesis-spectral-and-extended-spectrum-beta-lactamase-studies-of-transition-metal-tetraaza-macrocyclic-complexes
#19
Dinesh Kumar, Nutan Sharma, Manjula Nair
Urinary tract infections commonly occur in humans due to microbial pathogens invading the urinary tract, which can bring about a range of clinical symptoms and potentially fatal sequelae. The present study is aimed at addressing the development of a new antimicrobial agent against extended spectrum beta lactamase (ESBL) producing E. coli bacteria. We have synthesised some biologically potent (NNNN) donor macrocycles (L 1  = dibenzo[f,n]dipyrido[3,4-b:4',3'-j][1,4,9,12]tetraazacyclohexadecine-6,11,18,23(5H,12H, 7H, 24H)-tetraone, and L 2  = 6,12,19,25-tetraoxo-4,6,11,12,16,18,23,24-octahydrotetrabenzo [b,g,k,p][1,5,10,14]tetra azacyclooctadecine-2,13-dicarboxylic acid) and their Ti and Zr metal complexes in alcoholic media using microwave protocol...
January 18, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28096977/high-rates-of-multidrug-resistance-among-uropathogenic-escherichia-coli-in-children-and-analyses-of-esbl-producers-from-nepal
#20
Narayan Prasad Parajuli, Pooja Maharjan, Hridaya Parajuli, Govardhan Joshi, Deliya Paudel, Sujan Sayami, Puspa Raj Khanal
BACKGROUND: Emergence of Extended-spectrum beta-lactamase producing Escherichia coli causing urinary tract infections (UTI) among pediatric patients is an increasing problem worldwide. However, very little is known about pediatric urinary tract infections and antimicrobial resistance trend from Nepal. This study was conducted to assess the current antibiotic resistance rate and ESBL production among uropathogenic Escherichia coli in pediatric patients of a tertiary care teaching hospital of Nepal...
2017: Antimicrobial Resistance and Infection Control
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