Agnes Sauer, Benjamin Seeliger, Katharina Jandl, Lasti Erfinanda, Jochen Wilhelm, Ioannis Alexopoulos, Nelli Baal, Anna Birnhuber, Sascha David, Tobias Welte, Guillermo Barreto, Ulrich Gaertner, Grazyna Kwapiszewska, Werner Seeger, Wolfgang M Kuebler, Liliana Schaefer, Malgorzata Wygrecka
Shedding of hyaluronan (HA), the component of endothelial cell (EC) glycocalyx, has been associated with acute lung injury. HA degradation allows plasma proteins and fluid to penetrate across the vascular wall leading to lung edema formation and leukocyte recruitment. Here, we analyzed sHA levels and size in patients with community-acquired pneumonia (CAP) and acute respiratory distress syndrome (ARDS), correlated them to disease severity, and evaluated the impact of pneumolysin (PLY), the Streptococcus pneumoniae (S...
December 2022: Matrix Biology: Journal of the International Society for Matrix Biology