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https://www.readbyqxmd.com/read/28619884/effect-of-an-obesogenic-diet-on-circadian-activity-and-serum-hormones-in-old-monkeys
#1
Henryk F Urbanski, Kevin Mueller, Cynthia Bethea
Like women, old female rhesus macaques undergo menopause and show many of the same age-associated changes, including perturbed activity/rest cycles and altered circulating levels of many hormones. Previous studies showed that administration of an estrogen agonist increased activity in female monkeys, that hormone therapy (HT) increased activity in postmenopausal women, and that obesity decreased activity in women. The present study sought to determine if postmenopausal activity and circulating hormone levels also respond to HT when monkeys are fed a high-fat, high-sugar Western-style diet (WSD)...
June 15, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28584167/severe-cushing-s-syndrome-due-to-small-cell-prostate-carcinoma-a-case-and-review-of-literature
#2
Marianne Elston, Veronica Crawford, Michael Swarbrick, Michael Dray, Michelle Head, John V Conaglen
Cushings syndrome (CS) due to ectopic adrenocorticotrophic hormone (ACTH) is associated with a variety of tumours most of which arise in the thorax or abdomen. Prostate carcinoma is a rare but important cause of rapidly progressive CS. To report a case of severe CS due to ACTH production from prostate neuroendocrine carcinoma and summarise previous published cases. A 71 year old man presented with profound hypokalaemia, oedema and new onset hypertension. He reported two weeks of weight gain, muscle weakness, labile mood and insomnia...
June 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28580147/the-quantification-of-reproductive-hormones-in-the-hair-of-captive-adult-brown-bears-and-their-application-as-indicators-of-sex-and-reproductive-state
#3
Marc Cattet, Gordon B Stenhouse, David M Janz, Luciene Kapronczai, Joy Anne Erlenbach, Heiko T Jansen, O Lynne Nelson, Charles T Robbins, John Boulanger
Recognizing the potential value of steroid hormone measurements to augment non-invasive genetic sampling, we developed procedures based on enzyme-linked immunoassays to quantify reproductive steroid hormone concentrations in brown bear (Ursus arctos) hair. Then, using 94 hair samples collected from eight captive adult bears over a 2-year period, we evaluated (i) associations between hair concentrations of testosterone, progesterone, estradiol and cortisol; (ii) the effect of collecting by shaving vs. plucking; and (iii) the utility of reproductive hormone profiles to differentiate sex and reproductive state...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28515793/does-the-diurnal-cycle-of-cortisol-explain-the-relationship-between-physical-performance-and-cognitive-function-in-older-adults
#4
B Dijckmans, J Tortosa-Martínez, N Caus, G González-Caballero, B Martínez-Pelegrin, C Manchado-Lopez, J M Cortell-Tormo, I Chulvi-Medrano, A Clow
BACKGROUND: Regular physical activity is a promising strategy to treat and prevent cognitive decline. The mechanisms that mediate these benefits are not fully clear but physical activity is thought to attenuate the harmful effects of chronic psychological stress and hypercortisolism on cognition. However, the circadian pattern of cortisol secretion is complex and it is not known which aspects are most closely associated with increased cognitive function and better physical performance...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28511046/effects-of-stress-on-women-s-preference-for-male-facial-masculinity-and-their-endocrine-correlates
#5
Beate Ditzen, Simona Palm-Fischbacher, Lara Gossweiler, Livia Stucky, Ulrike Ehlert
Women's preferences for masculinity in men's faces seem to vary across the menstrual cycle and are assumed to be strongest around ovulation. A number of hormones have been proposed to underlie these subtle cyclic shifts. Furthermore, mating preferences are context-dependent, and stress has been found to alter mate choice, both in animals and humans. Currently, the effects of stress on women's preference for masculinity remain unknown. To examine the hormonal basis and the impact of stress on facial masculinity preference, we tested for within-subject changes in 52 healthy young women who underwent the Trier Social Stress Test (TSST) and the placebo-TSST in randomized order in the late follicular and mid-luteal phases of their menstrual cycle...
May 3, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28501551/contribution-of-stress-and-sex-hormones-to-memory-encoding
#6
Christian J Merz
Distinct stages of the menstrual cycle and the intake of oral contraceptives (OC) affect sex hormone levels, stress responses, and memory processes critically involved in the pathogenesis of mental disorders. To characterize the interaction of sex and stress hormones on memory encoding, 30 men, 30 women in the early follicular phase of the menstrual cycle (FO), 30 women in the luteal phase (LU), and 30 OC women were exposed to either a stress (socially evaluated cold-pressor test) or a control condition prior to memory encoding and immediate recall of neutral, positive, and negative words...
May 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28499851/effects-of-nutritional-history-on-stress-response-in-gibel-carp-carassius-auratus-gibelio-and-largemouth-bass-micropterus-salmoides
#7
Danli Jiang, Yubo Wu, Di Huang, Xing Ren, Yan Wang
The stress response of omnivorous gibel carp (Carassius auratus gibelio) and carnivorous largemouth bass (Micropterus salmoides) with different nutritional history were evaluated. A 2×2 layout, including two fish species (gibel carp or largemouth bass) and two nutritional history (fasted or fed to satiation for four weeks), was used. After feeding or fasting, the fishes were subjected to an acute handling. Fasting resulted in decrease of plasma glucose level and liver glycogen content of gibel carp and largemouth bass...
May 10, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28482120/fpca-based-method-to-select-optimal-sampling-schedules-that-capture-between-subject-variability-in-longitudinal-studies
#8
Meihua Wu, Ana Diez-Roux, Trivellore E Raghunathan, Brisa N Sánchez
A critical component of longitudinal study design involves determining the sampling schedule. Criteria for optimal design often focus on accurate estimation of the mean profile, although capturing the between-subject variance of the longitudinal process is also important since variance patterns may be associated with covariates of interest or predict future outcomes. Existing design approaches have limited applicability when one wishes to optimize sampling schedules to capture between-individual variability...
May 8, 2017: Biometrics
https://www.readbyqxmd.com/read/28479316/reference-intervals-for-plasma-concentrations-of-adrenal-steroids-measured-by-lc-ms-ms-impact-of-gender-age-oral-contraceptives-body-mass-index-and-blood-pressure-status
#9
Graeme Eisenhofer, Mirko Peitzsch, Denise Kaden, Katharina Langton, Christina Pamporaki, Jimmy Masjkur, George Tsatsaronis, Anastasios Mangelis, Tracy A Williams, Martin Reincke, Jacques W M Lenders, Stefan R Bornstein
BACKGROUND: Mass spectrometric-based measurements of the steroid metabolome have been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined reference intervals are important for interpreting such data. METHODS: Liquid chromatography-tandem mass spectrometry was used to establish reference intervals for 16 steroids (pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone, aldosterone, 18-oxocortisol, 18-hydroxycortisol, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androstenedione, testosterone) measured in plasma from 525 volunteers with (n=227) and without (n=298) hypertension, including 68 women on oral contraceptives...
July 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28476512/reactivity-of-alpha-rhythms-to-eyes-opening-the-berger-effect-during-menstrual-cycle-phases
#10
Olga M Bazanova, E D Nikolenko, Robert J Barry
The impact of the menstrual cycle on the alpha EEG reactivity to eyes opening (Berger effect) was studied in relation to hormonal and EMG indices. Repeated measurements of salivary progesterone and cortisol, forehead EMG, and EEG alpha-activity indices in 76 healthy women aged 18-27 were obtained in resting eyes closed (1min) and eyes open (30s) conditions. Ten recording sessions occurred, at 2-3day intervals, during 1-2 menstrual cycles. For example, if a participant had a menstrual cycle length of 30-32days, she could finish the investigation during 1cycle, but if she had a 24day cycle, she would finish the investigation over 1 1/2cycles...
May 2, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28456879/anti-inflammatory-effect-as-a-mechanism-of-effectiveness-underlying-the-clinical-benefits-of-pelotherapy-in-osteoarthritis-patients-regulation-of-the-altered-inflammatory-and-stress-feedback-response
#11
E Ortega, I Gálvez, M D Hinchado, J Guerrero, L Martín-Cordero, S Torres-Piles
The purpose of the present investigation was to evaluate whether an anti-inflammatory effect together with an improvement of the regulation of the interaction between the inflammatory and stress responses underlies the clinical benefits of pelotherapy in osteoarthritis (OA) patients. This study evaluated the effects of a 10-day cycle of pelotherapy at the spa centre 'El Raposo' (Spain) in a group of 21 OA patients diagnosed with primary knee OA. Clinical assessments included pain intensity using a visual analog scale; pain, stiffness and physical function using the Western Ontario and McMaster Universities Arthritis Index; and health-related quality of life using the EuroQol-5D questionnaire...
April 29, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28456776/effect-of-sprint-cycling-and-stretch-shortening-cycle-exercises-on-the-neuromuscular-immune-and-stress-indicators-in-young-men
#12
V Verbickas, N Baranauskiene, N Eimantas, S Kamandulis, S Rutkauskas, D Satkunskiene, S Sadauskas, M Brazaitis, A Skurvydas
Selection of optimal physical load is essential for desired adaptation including health benefits. We hypothesized that neuromuscular, immune and stress indicators will be higher after energy demanding sprint interval exercise (SIE) than to mechanically demanding stretch-shortening cycle exercise (SSE). The main aim of this study was to assess and compare the kinetics of blood brain-derived neurotrophic factor (BDNF), norepinephrine (NE) and cortisol (as stress indicators) and proinflammatory (IL-6) and anti-inflammatory (IL-10) cytokines within 24 hours after metabolically demanding SIE and after muscle damage inducing SSE...
February 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28432647/the-gender-attention-observational-study-gender-and-hormonal-status-differences-in-the-incidence-of-adverse-events-during-cyclosporine-treatment-in-psoriatic-patients
#13
Delia Colombo, Giuseppe Banfi, Nicoletta Cassano, Alessandra Graziottin, Gino Antonio Vena, Giovanni Gualberto Fiori, Emanuela Zagni, Luca Stingeni, Sergio Chimenti, Enzo Berardesca, Giuseppe Micali, Giuseppe Albertini, Clara De Simone, Gilberto Bellia
INTRODUCTION: Female sex has been shown to be a risk factor for the development of adverse drug reactions; however, this has not been studied for cyclosporine (CsA). The aim of this study was to investigate, in Italian dermatological practice, the influence of gender and menopause and related hormones on the incidence of adverse events (AEs) during CsA treatment in psoriatic patients. METHODS: Multicenter, prospective, observational study conducted from May 2011 to June 2013...
April 21, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28420550/effect-of-a-moderate-caffeine-dose-on-endurance-cycle-performance-and-thermoregulation-during-prolonged-exercise-in-the-heat
#14
Ross E Beaumont, Lewis J James
OBJECTIVES: This study investigated the influence of a moderate caffeine dose on endurance cycle performance and thermoregulation during prolonged exercise in high ambient temperature. DESIGN: Double-blind cross-over study. METHODS: Eight healthy, recreationally active males (mean±SD; age: 22±1 years; body mass: 71.1±8.5kg; VO2peak: 55.9±5.8mLkg(-1)min(-1); Wmax: 318±37W) completed one VO2peak test, one familiarisation trial and two experimental trials...
March 31, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28389217/supplementation-with-a-low-dose-of-octopamine-does-not-influence-endurance-cycling-performance-in-recreationally-active-men
#15
Ross E Beaumont, Philip Cordery, Lewis J James, Phillip Watson
OBJECTIVES: The aim of this study was to examine the influence of octopamine supplementation on endurance performance and exercise metabolism. DESIGN: Double-blind cross-over study. METHODS: Ten healthy, recreationally active men (Mean±SD; age: 24±2 years; body mass: 78.4±8.7kg; VO2peak: 50.5±6.8 mLkg(-1)min(-1)) completed one VO2peak test, one familiarisation trial and two experimental trials. After an overnight fast, participants ingested either a placebo or 150mg of octopamine 60min prior to exercise...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#16
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28381454/erythropoiesis-with-endurance-training-dynamics-and-mechanisms
#17
David Montero, Andreas Breenfeldt-Andersen, Laura Oberholzer, Thomas Haider, Jens Peter Goetze, Anne-Kristine Meinild-Lundby, Carsten Lundby
The purpose of the present study was to characterize the progression of red blood cell volume (RBCV) expansion and potential volumetric and endocrine regulators of erythropoiesis during endurance training (ET). Nine healthy untrained volunteers (age=27±4 years) underwent supervised ET consisting of 3-4 × 60 min cycle ergometry sessions per week for 8 weeks. Plasma volume (PV), RBCV and overnight fasting hematological markers were determined prior to and at weeks 2, 4 and 8 of ET. In addition, plasma erythropoietin (EPO), cortisol, copeptin and pro-atrial natriuretic peptide concentrations were measured during a 3-hour morning period at baseline and post-exercise at weeks 1 and 8...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28367365/daily-rhythms-of-behavioral-and-hormonal-patterns-in-male-dromedary-camels-housed-in-boxes
#18
Lydiane Aubè, Meriem Fatnassi, Davide Monaco, Touhami Khorchani, Giovanni Michele Lacalandra, Mohamed Hammadi, Barbara Padalino
BACKGROUND: Daily rhythmicity has been observed for a number of hormonal and behavioral variables in mammals. It can be entrained by several external factors, such as light-dark cycle and scheduled feeding. In dromedary camels, daily rhythmicity has been documented only for melatonin secretion and body temperature. In this study, the daily rhythmicity of behavioral repertoire, cortisol and testosterone levels was investigated in captive male camels. METHODS: Six clinically healthy male dromedary camels (Camelus dromedarius) were used...
2017: PeerJ
https://www.readbyqxmd.com/read/28355486/molecular-recognition-in-mitochondrial-cytochromes-p450-that-catalyze-the-terminal-steps-of-corticosteroid-biosynthesis
#19
COMPARATIVE STUDY
Hwei-Ming Peng, Richard J Auchus
The mitochondrial cytochromes P450 11B1 and P450 11B2 are responsible for the final stages of cortisol and aldosterone synthesis, respectively. Dysregulation of both enzymes has been implicated in secondary forms of hypertension. Molecular recognition of the cytochromes P450 with their corresponding redox partner is a key step in the catalytic cycle, yet the precise nature of the interaction of P450 11B1 or P450 11B2 with their proximal partner, adrenodoxin (Adx), is still unknown. Here, we obtained P450 11B1·Adx2 and P450 11B2·Adx2 complexes using the zero-length cross-linker ethyl-3-[3-(dimethylamino)propyl]carbodiimide, which formed best under low-ionic strength conditions...
May 2, 2017: Biochemistry
https://www.readbyqxmd.com/read/28333238/clustering-of-pcos-like-traits-in-naturally-hyperandrogenic-female-rhesus-monkeys
#20
D H Abbott, B H Rayome, D A Dumesic, K C Lewis, A K Edwards, K Wallen, M E Wilson, S E Appt, J E Levine
STUDY QUESTION: Do naturally occurring, hyperandrogenic (≥1 SD of population mean testosterone, T) female rhesus monkeys exhibit traits typical of women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Hyperandrogenic female monkeys exhibited significantly increased serum levels of androstenedione (A4), 17-hydroxyprogesterone (17-OHP), estradiol (E2), LH, antimullerian hormone (AMH), cortisol, 11-deoxycortisol and corticosterone, as well as increased uterine endometrial thickness and evidence of reduced fertility, all traits associated with PCOS...
April 1, 2017: Human Reproduction
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