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https://www.readbyqxmd.com/read/28324043/reduced-transforming-growth-factor-beta-activity-in-the-endometrium-of-women-with-heavy-menstrual-bleeding
#1
J A Maybin, L Boswell, V J Young, W C Duncan, Hod Critchley
Context: Heavy menstrual bleeding (HMB) is common and incapacitating. Aberrant menstrual endometrial repair may result in HMB. The TGFβ superfamily contributes to tissue repair, but its role in HMB is unknown. Objective: We hypothesised that TGFβ1 is important for endometrial repair and women with HMB have aberrant TGFβ1 activity at menses. Participants/Setting: Endometrial biopsies were collected from women and menstrual blood loss objectively measured (HMB >80ml/cycle, normal menstrual bleeding, NMB <80ml)...
January 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323919/steroids-regulate-cxcl4-in-the-human-endometrium-during-menstruation-to-enable-efficient-endometrial-repair
#2
J A Maybin, U Thiruchelvam, M Madhra, Ptk Saunders, Hod Critchley
Context: Repair of the endometrial surface at menstruation must be efficient to minimize blood loss and optimize reproductive function. The mechanism and regulation of endometrial repair remain undefined. Objective: To determine the presence/regulation of CXCL4 in the human endometrium, as a putative repair factor at menses. Patients/Setting: Endometrium was collected throughout the menstrual cycle from healthy women attending the gynecology department...
February 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28315609/the-levonorgestrel-releasing-intrauterine-device-potentiates-stress-reactivity
#3
Jurate Aleknaviciute, Joke H M Tulen, Yolanda B De Rijke, Christian G Bouwkamp, Mark van der Kroeg, Mirjam Timmermans, Vincent L Wester, Veerle Bergink, Witte J G Hoogendijk, Henning Tiemeier, Elisabeth F C van Rossum, Cornelis G Kooiman, Steven A Kushner
BACKGROUND: The levonorgestrel-releasing intrauterine device (LNG-IUD) is currently recommended as a first-line contraceptive with an exclusively local intrauterine influence. However, recent clinical trials have identified side effects of LNG-IUD that appear to be systemically mediated, including depressed mood and emotional lability. METHODS: We performed two experimental studies and a cross-sectional study. For each study, women were included from three groups: LNG-IUD (0...
February 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28299447/markers-of-physiological-stress-during-exercise-under-conditions-of-normoxia-normobaric-hypoxia-hypobaric-hypoxia-and-genuine-high-altitude
#4
David Richard Woods, John Paul O'Hara, Christopher John Boos, Peter David Hodkinson, Costas Tsakirides, Neil Edward Hill, Darren Jose, Amanda Hawkins, Kelly Phillipson, Antonia Hazlerigg, Nicola Arjomandkhah, Liam Gallagher, David Holdsworth, Mark Cooke, Nicholas Donald Charles Green, Adrian Mellor
PURPOSE: To investigate whether there is a differential response at rest and following exercise to conditions of genuine high altitude (GHA), normobaric hypoxia (NH), hypobaric hypoxia (HH), and normobaric normoxia (NN). METHOD: Markers of sympathoadrenal and adrenocortical function [plasma normetanephrine (PNORMET), metanephrine (PMET), cortisol], myocardial injury [highly sensitive cardiac troponin T (hscTnT)], and function [N-terminal brain natriuretic peptide (NT-proBNP)] were evaluated at rest and with exercise under NN, at 3375 m in the Alps (GHA) and at equivalent simulated altitude under NH and HH...
March 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28293860/tissue-specific-daily-variation-in-the-oxidative-status-of-sturgeon-acipenser-naccarii-and-rainbow-trout-oncorhynchus-mykiss-a-comparative-study
#5
M C Hidalgo, C E Trenzado, M Furné, A Beltrán, C Manzaneda, M García-Gallego, A Domezain, A Sanz
The oxidative status is associated with animal lifespan, metabolism, activity and circadian rhythms. The objective of this work is to study the time course of the oxidative status over a daily cycle in the plasma, liver and brain, and the changes in the plasma cortisol levels of sturgeon and trout. The knowledge of daily oxidative status will provide a better understanding of the trout and sturgeon physiology and adequate maintenance and food supply of farmed fish in relation to photoperiod. Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, DT-diaphorase activities, lipid peroxidation and cortisol were measured...
March 14, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28290940/effects-of-combat-deployment-on-anthropometrics-and-physiological-status-of-u-s-army-special-operations-forces-soldiers
#6
Emily K Farina, Jonathan C Taylor, Gary E Means, Kelly W Williams, Nancy E Murphy, Lee M Margolis, Stefan M Pasiakos, Harris R Lieberman, James P McClung
INTRODUCTION: U.S. Army Special Operations Forces (SOF) soldiers deploy frequently and conduct military operations through special warfare and surgical strike capabilities. Tasks required to execute these capabilities may induce physical and mental stress and have the potential to degrade soldier physiological status. No investigations have longitudinally characterized whether combat deployment alters anthropometrics or biochemical markers of physiological status in a SOF population of frequent deployers...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28263736/isotope-dilution-turboflow-lc-ms-ms-method-for-simultaneous-quantification-of-ten-steroid-metabolites-in-serum
#7
Tue Søeborg, Hanne Frederiksen, Trine Holm Johannsen, Anna-Maria Andersson, Anders Juul
An isotope-dilution TurboFlow-LC-MS/MS method for simultaneous quantification of the ten steroid metabolites dehydroepiandrosterone sulfate (DHEAS), progesterone, 17α-hydroxyprogesterone (17-OHP), Δ4-androstenedione (Adione), corticosterone, 11-deoxycortisol, cortisol, cortisone, testosterone (T), and estrone 3-sulfate (E1-S) in serum was developed and validated. Limits of quantification, variability (inter- and intra-day), analytical range and linearity were all found to be acceptable for clinical use. Furthermore, sample stability was evaluated including the influence of freeze-thaw cycles and the effects of temperature and storage time...
March 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28244020/air-travel-circadian-rhythms-hormones-and-autoimmunity
#8
REVIEW
J Torres-Ruiz, A Sulli, M Cutolo, Y Shoenfeld
Biological rhythms are fundamental for homeostasis and have recently been involved in the regulatory processes of various organs and systems. Circadian cycle proteins and hormones have a direct effect on the inflammatory response and have shown pro- or anti-inflammatory effects in animal models of autoimmune diseases. The cells of the immune system have their own circadian rhythm, and the light-dark cycle directly influences the inflammatory response. On the other hand, patients with autoimmune diseases characteristically have sleep disorders and fatigue, and in certain disease, such as rheumatoid arthritis (RA), a frank periodicity in the signs and symptoms is recognized...
February 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28212266/individual-patterns-in-blood-borne-indicators-of-fatigue-trait-or-chance
#9
Ross Julian, Tim Meyer, Hugh H K Fullagar, Sabrina Skorski, Mark Pfeiffer, Michael Kellmann, Alexander Ferrauti, Anne Hecksteden
Julian, R, Meyer, T, Fullagar, HHK, Skorski, S, Pfeiffer, M, Kellmann, M, Ferrauti, A, and Hecksteden, A. Individual patterns in blood-borne indicators of fatigue-trait or chance. J Strength Cond Res 31(3): 608-619, 2017-Blood-borne markers of fatigue such as creatine kinase (CK) and urea (U) are widely used to fine-tune training recommendations. However, predictive accuracy is low. A possible explanation for this dissatisfactory characteristic is the propensity of athletes to react to different patterns of fatigue indicators (e...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28185934/corticosteroids-deeply-depress-the-in-vitro-steroidogenic-capacity-of-eurasian-perch-ovary-at-the-end-of-the-reproductive-cycle
#10
S N M Mandiki, S Milla, S Nkogo Robles, P Kestemont
Corticosteroids play positive or negative role in the reproductive mechanisms of many fish species but the physiological contexts relating to such biphasic actions are not well defined. In the present study we investigated to what extent corticosteroids (cortisol-Co, 11-deoxycorticosterone-DOC) hormones may interfere with the steroidogenic capacity of Eurasian perch ovarian tissues, and we tested whether the negative effects of corticosteroids may be mitigated by potential stimulating endocrine factors, namely insulin-like growth factor-1 (IGF), human chorionic gonadotropin (HCG) or thyroid hormones (Triidothyronine-T3, thyroxine-T4)...
February 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28160246/hypogonadotropic-hypogonadism-in-males-with-glycogen-storage-disease-type-1
#11
Evelyn M Wong, Anna Lehman, Philip Acott, Jane Gillis, Daniel L Metzger, Sandra Sirrs
BACKGROUND: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles...
February 4, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28152431/blunted-cortisol-response-to-psychosocial-stress-in-atopic-patients-is-associated-with-decrease-in-salivary-alpha-amylase-and-aldosterone-focus-on-sex-and-menstrual-cycle-phase
#12
N Hlavacova, P Solarikova, M Marko, I Brezina, D Jezova
A decreased responsiveness of the hypothalamic-pituitary-adrenocortical axis to stress stimuli in patients with atopy is well documented. The aim of this study was to investigate personality traits, salivary alpha-amylase activity and the aldosterone response to psychosocial stress procedure based on public speech in atopic patients with respect to sex and the menstrual cycle (MC) phase. The study was performed in 106 subjects of both sexes, 53 atopic patients suffering from allergic rhinitis, allergic asthma or atopic dermatitis and 53 age-, sex-, the MC phase- and BMI- matched healthy controls...
January 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28121800/effects-of-hit-on-physiological-and-hormonal-adaptions-in-well-trained-cyclists
#13
Øystein Sylta, Espen Tønnessen, Øyvind Sandbakk, Daniel Hammarström, Jørgen Danielsen, Knut Skovereng, Bent R Rønnestad, Stephen Seiler
PURPOSE: Investigate development of specific performance adaptions and hormonal responses every 4 week during a 12-week HIT period in groups with different interval-training prescriptions. METHODS: Sixty-three well-trained cyclists performing a 12-week intervention consisting of 2-3 HIT sessionsweek in addition to ad libitum low intensity training. Groups were matched for total training load, but increasing HIT (INC) group (n=23) performed interval-sessions as 4x16 min in week 1-4, 4x8 min in week 5-8 and 4x4 min in week 9-12...
January 23, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28073304/the-impact-of-stress-on-odor-perception
#14
Matthias Hoenen, Oliver T Wolf, Bettina M Pause
The olfactory system and emotional systems are highly intervened and share common neuronal structures. The current study investigates whether emotional (e.g., anger and fear) and physiological (saliva cortisol) stress responses are associated with odor identification ability and hedonic odor judgments (intensity, pleasantness, and unpleasantness). Nineteen men participated in the modified Trier Social Stress Test (TSST) and a control session (cycling on a stationary bike). The physiological arousal was similar in both sessions...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28064085/cortisol-awakening-response-is-blunted-and-pain-perception-is-increased-during-menses-in-cyclic-women
#15
Tuba Ozgocer, Cihat Ucar, Sedat Yildiz
BACKGROUND AND AIMS: The incidence of menstrual symptoms is reported to be as high as 90% in cyclic women. These symptoms, including anxiety and pain, might be associated with cortisol, as its receptors are widely distributed in the brain areas associated with behavior. Therefore, the current study aimed to assess the cortisol awakening response (CAR) throughout the menstrual cycle and correlate it with pain perception and trait anxiety. MATERIALS AND METHODS: CAR was assessed by measuring salivary cortisol at 0, 15, 30, and 60min following awakening in the same women (n=59, age 22...
December 21, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28057508/the-humoral-immune-system-of-anadromous-fish
#16
REVIEW
Patty Zwollo
The immune system of anadromous fish is extremely complex, a direct consequence of their diadromous nature. Hormone levels fluctuate widely throughout their life cycle, as fish move between fresh and salt water. This poses major challenges to the physiology of anadromous fish, including adaptation to very different saline environments, distinct pathogen fingerprints, and different environmental stressors. Elevated cortisol and sex hormone levels inhibit B lymphopoiesis and IgM(+) antibody responses, while catecholamines, growth hormones and thyroid hormones are generally stimulatory and enhance the humoral immune response...
January 2, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28040605/g-protein-coupled-receptor-34-in-ovarian-granulosa-cells-of-cattle-changes-during-follicular-development-and-potential-functional-implications
#17
L J Spicer, L F Schütz, J A Williams, N B Schreiber, J R Evans, M L Totty, J N Gilliam
Abundance of G protein-coupled receptor 34 (GPR34) mRNA is greater in granulosa cells (GCs) of cystic vs normal follicles of cattle. The present experiments were designed to determine if GPR34 mRNA in granulosa cell [GC] changes during selection and growth of dominant follicles in cattle as well as to investigate the hormonal regulation of GPR34 mRNA in bovine GC in vitro. In Exp. 1, estrous cycles of nonlactating cows were synchronized and then ovariectomized on either day 3-4 or 5-6 after ovulation. GPR34 mRNA abundance in GC was 2...
April 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28040487/a-waterborne-chemical-cue-from-gulf-toadfish-opsanus-beta-prompts-pulsatile-urea-excretion-in-conspecifics
#18
Jeremy Fulton, Christophe M R LeMoine, Carol Bucking, Kevin V Brix, Patrick J Walsh, M Danielle McDonald
The Gulf toadfish (Opsanus beta) has a fully functional ornithine urea cycle (O-UC) that allows it to excrete nitrogenous waste in the form of urea. Interestingly, urea is excreted in a pulse across the gill that lasts 1-3h and occurs once or twice a day. Both the stress hormone, cortisol, and the neurotransmitter, serotonin (5-HT) are involved in the control of pulsatile urea excretion. This and other evidence suggests that urea pulsing may be linked to toadfish social behavior. The hypothesis of the present study was that toadfish urea pulses can be triggered by waterborne chemical cues from conspecifics...
December 28, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28006716/biomolecular-aspects-of-depression-a-retrospective-analysis
#19
Brandon N Peacock, David J Scheiderer, Gottfried H Kellermann
OBJECTIVE: The effects of psychological stress, oxidative stress, and chronic low grade inflammation on the neuro-immune connection have been implicated in the pathogenesis of depression. Thus, in the recent past, there has been a growing effort in determining the mechanism of this pathogenesis. While attempting to map out, this mechanism researchers and clinicians have searched for clinically relevant biomarkers for use in the diagnosis and for the assessment of those suffering from depression...
February 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27999088/interplay-between-the-endocrine-and-circadian-systems-in-fishes
#20
Esther Isorna, Nuria De Pedro, Ana Isabel Valenciano, Ángel Luis Alonso-Gómez, María Jesús Delgado
The circadian system is responsible for the temporal organisation of physiological functions which, in part, involves daily cycles of hormonal activity. In this review, we analyse the interplay between the circadian and endocrine systems in fishes. We first describe the current model of fish circadian system organisation and the basis of the molecular clockwork that enables different tissues to act as internal pacemakers. This system consists of a net of central and peripherally located oscillators, and can be synchronised by the light-dark and feeding-fasting cycles...
December 20, 2016: Journal of Endocrinology
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