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cortisol cycle

Hyoseung Shin, Soon-Jin Choi, A-Ri Cho, Dong Young Kim, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Stress is a known cause of hair loss in many species. OBJECTIVE: In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS: Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and corticotropin-releasing hormone levels, were measured...
October 2016: Annals of Dermatology
Salzitsa Anastasova, Blair Crewther, Pawel Bembnowicz, Vincenzo Curto, Henry Md Ip, Bruno Rosa, Guang-Zhong Yang
In sport, exercise and healthcare settings, there is a need for continuous, non-invasive monitoring of biomarkers to assess human performance, health and wellbeing. Here we report the development of a flexible microfluidic platform with fully integrated sensing for on-body testing of human sweat. The system can simultaneously and selectively measure metabolite (e.g. lactate) and electrolytes (e.g. pH, sodium) together with temperature sensing for internal calibration. The construction of the platform is designed such that continuous flow of sweat can pass through an array of flexible microneedle type of sensors (50µm diameter) incorporated in a microfluidic channel...
September 21, 2016: Biosensors & Bioelectronics
David C Nieman, Kevin A Zwetsloot, Dominic D Lomiwes, Mary P Meaney, Roger D Hurst
The cytokine response to heavy exertion varies widely for unknown reasons, and this study evaluated the relative importance of glycogen depletion, muscle damage, and stress hormone changes on blood and muscle cytokine measures. Cyclists (N = 20) participated in a 75-km cycling time trial (168 ± 26.0 min), with blood and vastus lateralis muscle samples collected before and after. Muscle glycogen decreased 77.2 ± 17.4%, muscle IL-6, IL-8, and MCP-1 mRNA increased 18.5 ± 2.8-, 45.3 ± 7.8-, and 8.25 ± 1.75-fold, and muscle IL-6, IL-8, and MCP-1 protein increased 70...
2016: Frontiers in Physiology
Kazuyo Fujimoto, Takatoshi Nakashima, Kazunari Sasaki, Kenichi Hayashi, Masao Hanafusa, Shiei Yoshida, Satoshi Myojo, Shun-Ichi Yoshida, Shigeaki Sawai, Nobuya Sano
A 48-year-old woman with a history of autoimmune hemolytic anemia and taking long-term corticosteroid therapy presented with a 3-month history of general fatigue, abdominal distension, and pigmentation. A computed tomography scan of the abdomen showed a tumor in the sigmoid colon and multiple metastatic nodules in the liver. A colonoscopy revealed an obstructing mass with the presence of an irregular ulcer in the sigmoid colon. Following biopsy and histopathological analysis, the patient was diagnosed with neuroendocrine carcinoma (NEC) of the colon...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Marie Aarrebo Jensen, Åse Marie Hansen, Jesper Kristiansen, Kirsten Nabe-Nielsen, Anne Helene Garde
Night work is associated with a large range of acute health problems and possibly also health consequences in the long run. Yet, only very few field studies specifically investigate the effects of consecutive night shift on key physiological regulatory systems. In this field study, we investigated the effects of consecutive night shifts on three hormones, melatonin, cortisol, and testosterone, among police officers at work. More specifically, the aim was to investigate how the diurnal rhythms of melatonin, cortisol, and testosterone responded to two, four, and seven consecutive night shifts and a corresponding number of days for recovery...
August 11, 2016: Chronobiology International
Lars Peter Holst Andersen
The hormone, melatonin is produced with circadian rhythm by the pineal gland in humans. The melatonin rhythm provides an endogenous synchronizer, modulating e.g. blood pressure, body temperature, cortisol rhythm, sleep-awake-cycle, immune function and anti-oxidative defence. Interestingly, a number of experimental animal studies demonstrate significant dose-dependent anti-nociceptive effects of exogenous melatonin. Similarly, recent experimental- and clinical studies in humans indicate significant analgesic effects...
October 2016: Danish Medical Journal
Jurate Aleknaviciute, Joke H M Tulen, Mirjam Timmermans, Yolanda B de Rijke, Elisabeth F C van Rossum, Frank H de Jong, Steven A Kushner
STUDY QUESTION: Does adrenocorticotropic hormone (ACTH) induce gonadotropin release in premenopausal women? SUMMARY ANSWER: Administration of ACTH stimulates gonadotropin release, most likely by stimulation of the production of cortisol, in premenopausal women. WHAT IS KNOWN ALREADY: In animal models, acute activation of the hypothalamic-pituitary-adrenal (HPA) axis has been shown to induce gonadotropin release in the presence of sufficiently high estrogen levels...
October 2016: Human Reproduction
R Käser, R M Bruckmaier, S Thomas, H Sieme, C Wedekind, D Burger
Oxytocin is a hormone that may not only influence reproductive mechanisms in mammals but also their social behavior, including pair bonding. We therefore tested if the concentrations of oxytocin and other hormones reveal mate preferences of 13 mares in estrus. Each mare was first exposed to two stallions (haphazardly selected out of seven) and her behavior recorded. The mare was then returned to her box (i.e., no contact to stallions during that time). Approximately 4.5 hours later, venous blood samples were collected every minute during 30 minutes preceding exposure to one of the two previously used stallions, 6 minutes during exposure, and 30 minutes after exposure back in the mare's box...
July 25, 2016: Theriogenology
Blair T Crewther, Andrew G Thomas, Steve Stewart-Williams, Liam P Kilduff, Christian J Cook
This study examined the moderating effect of cortisol (C) on the relationship between testosterone (T) and hand-grip strength (HGS) in healthy young men. Sixty-five males were monitored for salivary T, C and HGS before and 15 min after a short bout (5 × 6-s trials) of sprint cycling exercise. Sprint exercise promoted (p < .05) positive changes in T (6.1 ± 24.9%) and HGS (3.4 ± 7.5%), but a negative C response (-14.4 ± 33.1%). The T and C measures did not independently predict HGS, but a significant T × C interaction was found in relation to these outcomes...
August 25, 2016: European Journal of Sport Science
Emad A S Al-Dujaili, Nimrah Munir, Raquel Revuelta Iniesta
BACKGROUND AND OBJECTIVES: Evidence suggests associations between vitamin D deficiency and cardiovascular disease (CVD) risk factors, including hypertension and excessive cortisol levels. Also, vitamin D levels may impact exercise performance. Thus, we aimed to investigate the effects of vitamin D intake on cardiovascular risk factors, free urinary cortisol and exercise performance. METHODS: A randomized placebo-controlled single-blinded parallel trial was conducted in healthy participants (n = 15)...
August 2016: Therapeutic Advances in Endocrinology and Metabolism
Erling Thom
The stress hormone, cortisol, is known to affect the function and cyclic regulation of the hair follicle. When cortisol is present at high levels it has been demonstrated to reduce the synthesis and accelerate the degradation of important skin elements, namely hyaluronan and proteoglycans by approximately 40%. The following discussion outlines the relationship between stress, cortisol, and the effect on the normal function of the hair follicle. As a result of this connection, important correlations have been established in the literature to form a basis for novel, effective treatments of stress-related hair growth disorders...
August 1, 2016: Journal of Drugs in Dermatology: JDD
N Chergui, P Mormede, A Foury, F Khammar, Z Amirat
Our work aims at the exploration of cortisol secretion in the Bedouin goat, native to the Algerian Sahara desert, to understand the mechanisms of adaptation to extreme hot climates. In the present study, diurnal and seasonal variations of cortisol concentrations were measured in basal conditions, as well as the response to ACTH stimulation tests across seasons in bucks. The plasma concentrations of cortisol showed no diurnal cycle but a large variation across seasons. The highest levels occurred in summer and winter when the environmental conditions are at their extreme levels...
August 11, 2016: Animal: An International Journal of Animal Bioscience
E S Evans, A C Hackney, M M Pebole, R G McMurray, H B Muss, A M Deal, C L Battaglini
The aim of this study was to explore the effect of one bout of aerobic exercise on epinephrine, norepinephrine, cortisol, glucose, lactate, and free fatty acid (FFA) responses in breast cancer survivors and healthy controls. 9 female breast cancer survivors and 9 women without a history of cancer completed 30 min of cycle ergometry exercise at 60% of VO2peak. Blood samples were taken pre-exercise, immediately post-exercise, and 2 h post-exercise from which plasma concentrations of study variables were measured...
August 4, 2016: International Journal of Sports Medicine
Robert Miller, Tobias Stalder, Marc Jarczok, David M Almeida, Ellena Badrick, Meike Bartels, Dorret I Boomsma, Christopher L Coe, Marieke C J Dekker, Bonny Donzella, Joachim E Fischer, Megan R Gunnar, Meena Kumari, Florian Lederbogen, Christine Power, Carol D Ryff, S V Subramanian, Henning Tiemeier, Sarah E Watamura, Clemens Kirschbaum
Diurnal salivary cortisol profiles are valuable indicators of adrenocortical functioning in epidemiological research and clinical practice. However, normative reference values derived from a large number of participants and across a wide age range are still missing. To fill this gap, data were compiled from 15 independently conducted field studies with a total of 104,623 salivary cortisol samples obtained from 18,698 unselected individuals (mean age: 48.3 years, age range: 0.5-98.5 years, 39% females). Besides providing a descriptive analysis of the complete dataset, we also performed mixed-effects growth curve modeling of diurnal salivary cortisol (i...
November 2016: Psychoneuroendocrinology
Emerson Franchini, Ursula F Julio, Valéria L G Panissa, Fábio S Lira, José Gerosa-Neto, Braulio H M Branco
PURPOSE: The present study investigated the effects of high-intensity intermittent training (HIIT) on lower- and upper-body graded exercise and high-intensity intermittent exercise (HIIE, four Wingate bouts) performance, and on physiological and muscle damage markers responses in judo athletes. METHODS: Thirty-five subjects were randomly allocated to a control group (n = 8) or to one of the following HIIT groups (n = 9 for each) and tested pre- and post-four weeks (2 training d·wk(-1)): (1) lower-body cycle-ergometer; (2) upper-body cycle-ergometer; (3) uchi-komi (judo technique entrance)...
2016: Frontiers in Physiology
Jurate Aleknaviciute, Joke H M Tulen, Astrid M Kamperman, Yolanda B de Rijke, Cornelis G Kooiman, Steven A Kushner
BACKGROUND: Maladaptive emotional control is a defining feature of personality disorders. Yet little is known about the underlying physiological dynamics of emotional reactivity to psychosocial stress across distinct personality disorders. The current study compared subjective emotional responses with autonomic nervous system and HPA axis physiological responses to psychosocial stress in women with cluster C personality disorder (CPD) and borderline personality disorder (BPD). METHODS: Subjective mood ratings, salivary cortisol, heart rate (HR), and skin conductance level (SCL) were assessed before, during, and after exposure to a standardized psychosocial stress paradigm (Trier Social Stress Test, TSST) in 26 women with BPD, 20 women with CPD, and 35 healthy female controls...
October 2016: Psychoneuroendocrinology
Rita Nanda, Erica M Stringer-Reasor, Poornima Saha, Masha Kocherginsky, Jean Gibson, Bernadette Libao, Philip C Hoffman, Elias Obeid, Douglas E Merkel, Galina Khramtsova, Maxwell Skor, Thomas Krausz, Ronald N Cohen, Mark J Ratain, Gini F Fleming, Suzanne D Conzen
PURPOSE: Glucocorticoid receptor (GR) overexpression is associated with poor prognosis ER-negative breast cancer. GR antagonism with mifepristone increases chemotherapy-induced breast cancer cell death, therefore we conducted a phase I clinical trial of mifepristone and nab-paclitaxel in advanced breast cancer. METHODS: A novel randomized phase I design was used to assess the effect of mifepristone on nab-paclitaxel pharmacokinetics and toxicity. Patients were randomized to placebo or mifepristone for the first cycle; mifepristone was given to all for subsequent cycles...
2016: SpringerPlus
Al Caraffa, E Spinas, S K Kritas, G Lessiani, G Ronconi, A Saggini, P Antinolfi, J Pizzicannella, E Toniato, T C Theoharides, P Conti
Endocrinology systems exert an important effect on vascular function and have direct actions on blood vessels. Estrogens provoke an increase in skin elasticity, epidermal hydration, skin thickness, reduce skin wrinkles and augment the content of collagen and the level of vascularisation. Therefore, there is an intricate cross-talk between skin conditions and stress. In stress, β2--adrenoreceptor (β2AR) pathway, cortisol, epinephrine and norepinephrine increase DNA damage and interfere with the regulation of the cell cycle, contributing to aging and skin diseases...
April 2016: Journal of Biological Regulators and Homeostatic Agents
Tristan Martin, Sébastien Moussay, Ingo Bulla, Jan Bulla, Michel Toupet, Olivier Etard, Pierre Denise, Damien Davenne, Antoine Coquerel, Gaëlle Quarck
BACKGROUND: New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothalamic regulation of circadian rhythms on Earth, which raises the question of whether daily rhythms might be altered due to vestibular pathology in humans. The aim of this study was to evaluate human circadian rhythmicity in people presenting a total bilateral vestibular loss (BVL) in comparison with control participants...
2016: PloS One
Vanesa Hidalgo, Mercedes Almela, Matias M Pulopulos, Alicia Salvador
There are large individual differences in age-related cognitive decline. Hypothalamic-pituitary-adrenal axis (HPA-axis) functioning has been suggested as one of the mechanisms underlying these differences. This study aimed to investigate the relationships between the diurnal cortisol cycle, measured as the cortisol awakening response (CAR), and the diurnal cortisol slope (DCS) and the memory performance of healthy older people. To do so, we assessed the verbal, visual, and working memory performance of 64 participants (32 men) from 57 to 76 years old who also provided 14 saliva samples on two consecutive weekdays to determine their diurnal cortisol cycle...
September 2016: Psychoneuroendocrinology
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