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https://www.readbyqxmd.com/read/29319131/temozolomide-therapy-for-aggressive-pituitary-crooke-s-cells-corticotropinoma-causing-cushing-s-disease-a-case-report-with-literature-review
#1
Aleksandra Gilis-Januszewska, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Grzegorz Sokołowski, Anna Sowa-Staszczak, Łukasz Kluczyński, Dorota Pach, Grzegorz Zieliński, Alicja Hubalewska-Dydejczyk
AbstractContext: Aggressive pituitary tumours causing Cushing's Disease are very rare, difficult to treat, and usually resistant to conventional therapy. There is growing evidence for the use of temozolomide (TZM), an alkylating chemotherapeutic agent, as first line chemotherapy in tumours resistant to repeated neurosurgery, radiotherapy and adrenalectomy. OBJECTIVE: To present the response to TMZ in a rare case of an aggressive pituitary tumour in the course of Cushing's Disease and to review the literature referring to similar cases...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29314170/pulsatility-of-glucocorticoid-hormones-in-pregnancy-changes-with-gestation-and-obesity
#2
Laura I Stirrat, Jamie J Walker, Ksenia Stryjakowska, Natalie Jones, Natalie Zm Homer, Ruth Andrew, Jane E Norman, Stafford L Lightman, Rebecca M Reynolds
OBJECTIVE: Hypothalamic-pituitary-adrenal-axis (HPA) activity is decreased in obese pregnancy and associates with increased fetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal fetal growth but little is known about glucocorticoid pulsatility in pregnancy. We aimed to investigate the ultradian rhythm of glucocorticoid secretion during obese and lean pregnancy and non-pregnancy. DESIGN: Serum cortisol, cortisone, corticosterone and 11-dehydrocorticosterone were measured by LC-MS/MS from samples obtained at 10-minute intervals between 08...
January 5, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29306361/steroid-hormone-concentrations-and-body-mass-are-differently-affected-by-polyunsaturated-fatty-acids-during-the-oestrous-cycle-in-guinea-pigs
#3
Matthias Nemeth, Bernard Wallner, Carina Siutz, Elisabeth Pschernig, Karl-Heinz Wagner, Eva Millesi
Reproductive functions in female mammals can be significantly affected by the actions of dietary polyunsaturated fatty acids (PUFAs) on steroid hormone secretion rates. Nevertheless, the effects of plasma free PUFAs on the oestrous cycle have seldom been considered. Therefore, in the present study, the diet of domestic guinea pigs was supplemented with high concentrations of different PUFAs and the effects of altered plasma PUFA patterns on steroid hormone concentrations, measured non-invasively, and body mass during oestrus and dioestrus were analysed...
January 8, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29304407/the-effect-of-chlorpyrifos-on-salinity-acclimation-of-juvenile-rainbow-trout-oncorhynchus-mykiss
#4
Bagher Mojazi Amiri, Elvis Genbo Xu, Allison Kupsco, Marissa Giroux, Mahbubeh Hoseinzadeh, Daniel Schlenk
As a part of their unique life cycle, most salmonids undergo a transition from fresh water to salt water requiring various adjustments in metabolism, osmoregulation and ion regulation. Exposure to pesticides may affect the acclimation of juvenile salmonids to salt water during downstream migration to estuaries. Using the Caspian Sea as a model waterbody, the present study aimed to determine how the toxicity of the organophosphate pesticide chlorpyrifos (CPF) impacts saline acclimation of rainbow trout (Oncorhynchus mykiss)...
December 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29277698/interactions-between-observer-and-stimuli-fertility-status-endocrine-and-perceptual-responses-to-intrasexual-vocal-fertility-cues
#5
Grant M Ostrander, R Nathan Pipitone, Melanie L Shoup-Knox
Both men and women find female voices more attractive at higher fertility times in the menstrual cycle, suggesting the voice is a cue to fertility and/or hormonal status. Preference for fertile females' voices provides males with an obvious reproduction advantage, however the advantage for female listeners is less clear. One possibility is that attention to the fertility status of potential rivals may enable women to enhance their own reproductive strategies through intrasexual competition. If so, the response to having high fertility voices should include hormonal changes that promote competitive behavior...
December 22, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29250769/a-prospective-investigation-of-perceived-stress-infertility-related-stress-and-cortisol-levels-in-women-undergoing-in-vitro-fertilization-influence-on-embryo-quality-and-clinical-pregnancy-rate
#6
Carolyn E Cesta, Anna L Johansson, Julius Hreinsson, Kenny A Rodriguez-Wallberg, Jan I Olofsson, Jan Holte, Håkan Wramsby, Margareta Wramsby, Sven Cnattingius, Alkistis Skalkidou, Anastasia Nyman Iliadou
INTRODUCTION: Women undergoing fertility treatment experience high levels of stress. However, it remains uncertain if and how stress influences in vitro fertilization (IVF) cycle outcome. This study aimed to investigate whether self-reported perceived and infertility-related stress and cortisol levels were associated with IVF cycle outcomes. MATERIAL AND METHODS: A prospective cohort of 485 women receiving fertility treatment was recruited from September 2011 to December 2013 and followed until December 2014...
December 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29248511/daily-fluctuations-of-progesterone-and-testosterone-are-associated-with-fibromyalgia-pain-severity
#7
Meredith Schertzinger, Kate Wesson-Sides, Luke Parkitny, Jarred Younger
The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Cortisol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity...
December 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29230292/multiple-steroid-and-thyroid-hormones-detected-in-baleen-from-eight-whale-species
#8
Kathleen E Hunt, Nadine S Lysiak, Jooke Robbins, Michael J Moore, Rosemary E Seton, Leigh Torres, C Loren Buck
Recent studies have demonstrated that some hormones are present in baleen powder from bowhead (Balaena mysticetus) and North Atlantic right (Eubalaena glacialis) whales. To test the potential generalizability of this technique for studies of stress and reproduction in large whales, we sought to determine whether all major classes of steroid and thyroid hormones are detectable in baleen, and whether these hormones are detectable in other mysticetes. Powdered baleen samples were recovered from single specimens of North Atlantic right, bowhead, blue (Balaenoptera [B...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29209867/non-specific-effects-and-clusters-of-women-with-painful-tmd-responders-and-non-responders-to-lllt-double-blind-randomized-clinical-trial
#9
Laís Valencise Magri, Vinícius Almeida Carvalho, Flávia Cássia Cabral Rodrigues, César Bataglion, Christie Ramos Andrade Leite-Panissi
The aim was to analyze the non-specific effects (placebo, spontaneous remission, and regression to the mean) of the low-level laser therapy (LLLT) in women with myofascial pain (painful temporomandibular disorder (TMD)), as well as to differentiate between responders and non-responder clusters to active and placebo LLLT according to the anxiety levels, salivary cortisol, use of oral contraceptives, and premenstrual period. Sixty-four women diagnosed with myofascial pain (Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)) were included, divided into laser (n = 20), placebo group (n = 21), and 23 controls (without treatment (WT))...
December 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29199102/effect-of-repeated-adrenocorticotropic-hormone-administration-on-reproductive-function-and-hair-cortisol-concentration-during-the-estrous-cycle-in-goats
#10
Natsumi Endo, Hiroaki Yamane, Larasati Puji Rahayu, Tomomi Tanaka
Measurement of the cortisol concentration in hair has been used as an index of chronic stress in several species including humans, wildlife and domestic animals. However, how accurately the cortisol concentration in hair reflects the changes in circulating cortisol concentrations has not been well documented. The objective of the present study was to examine the effect of repeated adrenocorticotropic hormone (ACTH) administration on the reproductive function during the estrous cycle and hair cortisol concentrations in goats...
November 30, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29180230/glucocorticoids-genes-and-brain-function
#11
REVIEW
Grzegorz R Juszczak, Adrian M Stankiewicz
The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined with biochemical and physiological data to create an integrated view of the effects induced by GCs. The most frequently reported genes were Errfi1 and Ddit4. Their up-regulation was associated with the altered transcription of genes regulating growth factor and mTORC1 signaling (Gab1, Tsc22d3, Dusp1, Ndrg2, Ppp5c and Sesn1) and progression of the cell cycle (Ccnd1, Cdkn1a and Cables1)...
November 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29176713/rapid-resetting-of-human-peripheral-clocks-by-phototherapy-during-simulated-night-shift-work
#12
Marc Cuesta, Philippe Boudreau, Nicolas Cermakian, Diane B Boivin
A majority of night shift workers have their circadian rhythms misaligned to their atypical schedule. While bright light exposure at night is known to reset the human central circadian clock, the behavior of peripheral clocks under conditions of shift work is more elusive. The aim of the present study was to quantify the resetting effects of bright light exposure on both central (plasma cortisol and melatonin) and peripheral clocks markers (clock gene expression in peripheral blood mononuclear cells, PBMCs) in subjects living at night...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29171482/-sleep-quality-and-hormone-levels-in-the-morning-and-evening-hours-under-chemical-pollution
#13
R O Budkevich, E V Budkevich
AIM: To evaluate self-assessment of sleep and the level of hormones in the morning and evening in chemical pollution conditions. MATERIAL AND METHODS: Three hundred adolescent and adult men living in the regions with low and high levels of chemical pollution were examined using questionnaires for self-assessment of quality of sleep, sleep hygiene, daytime sleepiness. Levels of cortisol and testosterone in the saliva were determined in the morning and evening hours by ELISA...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29170001/heightened-cortisol-response-to-exercise-challenge-in-women-with-functional-hypothalamic-amenorrhea
#14
Kristen M Sanders, Jennifer F Kawwas, Tammy Loucks, Sarah L Berga
BACKGROUND: Functional hypothalamic amenorrhea is characterized by anovulation due to reduced gonadotropin-releasing hormone drive and is associated with hypercortisolemia that has been linked to heightened hypothalamic-pituitary-adrenal reactivity to common psychological and metabolic challenges. OBJECTIVE: We hypothesized that women with functional hypothalamic amenorrhea would display greater cortisol responses to exercise challenge than ovulatory, eumenorrheic women...
November 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29151070/circadian-rhythms-of-melatonin-and-cortisol-in-manifest-huntington-s-disease-and-in-acute-cortical-ischemic-stroke
#15
A Adamczak-Ratajczak, J Kupsz, M Owecki, D Zielonka, A Sowinska, Z Checinska-Maciejewska, H Krauss, S Michalak, M Gibas-Dorna
Recent studies indicate disruptions to the circadian system in brain injury and neurodegeneration. The results, however, are often not consistent and limited by measurement of only one circadian marker and by infrequent sampling rates. In this study, we examined diurnal rhythmicity in different stages of Huntington (HD) disease and in patients with acute moderate ischemic stroke (AIS) outside the retinohypothalamic pathway by evaluating serum concentrations of melatonin and cortisol at twelve timepoints. All study participants were subjected to the same study protocol of 12-hour light/dark cycle and controlled room conditions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29140897/psychological-and-psychophysiological-effects-of-recuperative-music-postexercise
#16
Costas I Karageorghis, Andrew C Bruce, Suzanne T Pottratz, Rebecca C Stevens, Marcelo Bigliassi, Mark Hamer
PURPOSE: Few studies have examined the psychological and psychophysiological effects of recuperative music following exhaustive exercise. The main purpose of the present study was to examine the effects of two music conditions compared with a no-music control on psychological and psychophysiological recovery processes post-exercise. METHODS: A randomized, fully counterbalanced, crossover design was used. Core affect, salivary cortisol, heart rate, and blood pressure were measured before exhaustive exercise, immediately after, and in 10-, 20-, and 30-min intervals during passive recovery (21 women and 21 men; 20...
November 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29111782/circadian-profiles-of-progesterone-gonadotropins-cortisol-and-corticotropin-in-cycling-and-postmenopausal-women
#17
Anne Caufriez, Rachel Leproult, Georges Copinschi
Little is known about the regulation of temporal variations of progesterone over the 24-hr span in young cycling women as well as in postmenopausal women. The purpose of the present study was to investigate the relationships between diurnal variations of progesterone and diurnal variations of hormones of the gonadotropic and corticotropic axes, and to provide further information on the source of progesterone secretion under physiological conditions. Twenty-four-hour hormonal profiles were explored under well-controlled laboratory conditions in 10 healthy women (21-36 yr old) with normal ovulatory cycles during early-mid follicular and late luteal phases, and in 8 healthy postmenopausal women (48-74 yr old)...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29110806/masturbation-to-orgasm-stimulates-the-release-of-the-endocannabinoid-2-arachidonoylglycerol-in-humans
#18
Johannes Fuss, Laura Bindila, Klaus Wiedemann, Matthias K Auer, Peer Briken, Sarah V Biedermann
BACKGROUND: Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists on rodent sexual activity. However, the involvement of endocannabinoids in human sexual behavior has not been studied. AIM: To investigate plasma endocannabinoid levels before and after masturbation in healthy male and female volunteers...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29106702/hypothalamic-pituitary-adrenal-hpa-axis-suppression-after-treatment-with-glucocorticoid-therapy-for-childhood-acute-lymphoblastic-leukaemia
#19
REVIEW
Niki Rensen, Reinoud Jbj Gemke, Elvira C van Dalen, Joost Rotteveel, Gertjan Jl Kaspers
BACKGROUND: Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses can suppress the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis suppression resulting in reduced cortisol response may cause an impaired stress response and an inadequate host defence against infection, which remain a cause of morbidity and death. Suppression commonly occurs in the first days after cessation of glucocorticoid therapy, but the exact duration is unclear...
November 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29076960/effects-of-combined-strength-and-endurance-training-on-physical-performance-and-biomarkers-of-healthy-young-women
#20
Heikki KyrÖlÄinen, Anthony C Hackney, Riikka Salminen, Johanna Repola, Keijo HÄkkinen, Jari Haimi
Cardiovascular fitness has decreased and obesity has increased in youth-adults world-wide during the last ten years. Therefore, there is an urgent need to find out optimal exercise training programs for improving physical performance and health outcomes, especially, among sedentary women. Subjects were 25-30-year-old females with very low physical activity, and 65 % of them were overweight (BMI >25). They performed endurance and strength training three times a week for nine weeks. Independent strength training and instructed endurance training by indoor cycling were prescribed...
October 20, 2017: Journal of Strength and Conditioning Research
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