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epilepsy comorbidity

Kirsten Labudda, Michael Frauenheim, Dominik Illies, Inga Miller, Mario Schrecke, Nadine Vietmeier, Christian Brandt, Christian G Bien
Several studies found high prevalence rates of psychiatric disorders in patients with pure psychogenic nonepileptic seizures (PNES). Traumatic experiences were also reported to be elevated in patients with PNES and were discussed as a crucial risk factor for the development of PNES. Much less is known about psychiatric comorbidities and specifically, about trauma history in patients with PNES and coexisting epilepsy. Here, we aimed at directly comparing psychiatric disorders and traumatic life experiences in patients with pure PNES and in patients with PNES and coexisting epilepsy...
September 18, 2018: Epilepsy & Behavior: E&B
Kavelin Rumalla, Kyle A Smith, Vijay Letchuman, Mrudula Gandham, Rachana Kombathula, Paul M Arnold
OBJECTIVE: Posttraumatic seizures (PTSs) are the most common complication following a traumatic brain injury (TBI) and may lead to posttraumatic epilepsy. PTS is well described in the adult literature but has not been studied extensively in children. Here, the authors utilized the largest nationwide registry of pediatric hospitalizations to report the national incidence, risk factors, and outcomes associated with PTS in pediatric TBI. METHODS: The authors queried the Kids' Inpatient Database (KID) using ICD-9-CM codes to identify all patients (age < 21 years) who had a primary diagnosis of TBI (850...
September 21, 2018: Journal of Neurosurgery. Pediatrics
James Gardner, Kevin W Sexton, John Taylor, William Beck, Mary Katherine Kimbrough, Ben Davis, Avi Bhavaraju, Saleema Karim, Austin Porter
Background: Readmissions after a traumatic brain injury (TBI) have significant impact on long-term patient outcomes through interruption of rehabilitation. This study examined readmissions in a rural population, hypothesizing that readmitted patients after TBI will be older and have more comorbidities than those not readmitted. Methods: Discharge data on all patients 15 years and older who were admitted to an Arkansas-based hospital for TBI were obtained from the Arkansas Hospital Discharge Data System from 2010 to 2014...
2018: Trauma surgery & acute care open
Marie Bendix, Ulla Lindbom
Epilepsy has a diverse spectrum of consequences that can necessitate multi-professional cooperation in order to guarantee a high level of care. Psychiatric comorbidity is common, which influences quality of life, seizure control and mortality. Multi-professional teams, with participation from neurology, psychiatry, psychology, occupational therapy and social work, can together tailor the individual care for patients with complex needs. Close cooperation among team members increases quality and efficiency of care and reassurance for patients and their relatives while decreasing the work load for individual team members...
September 17, 2018: Läkartidningen
Remi Stevelink, Bobby P C Koeleman, Josemir W Sander, Floor E Jansen, Kees P J Braun
BACKGROUND: Juvenile myoclonic epilepsy (JME) is a common epilepsy syndrome for which treatment response is generally assumed to be good. We aimed to determine the prevalence and prognostic risk factors for refractoriness of JME. METHODS: We systematically searched PubMed and Embase and included 43 eligible studies, reporting seizure outcome after anti-epileptic drug treatment JME cohorts. We defined refractory JME as persistence of any seizure despite AED treatment and performed a random-effects meta-analysis to assess the prevalence of refractory JME and of seizure-recurrence after AED withdrawal in individuals with well-controlled seizures...
September 17, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Sue Woolfenden, Claire Galea, Hayley Smithers-Sheedy, Eve Blair, Sarah Mcintyre, Sue Reid, Michael Delacy, Nadia Badawi
AIM: To investigate the impact of socio-economic disadvantage on indicators of cerebral palsy (CP) severity - motor impairment, intellectual disability, and the presence of severe comorbidities - in children with CP in Australia. METHOD: Data from the Australian Cerebral Palsy Register were analysed. Socio-economic disadvantage was assessed using maternal age, maternal country of birth, and a measure of neighbourhood socio-economic status (SES) at the time of the child's birth...
September 17, 2018: Developmental Medicine and Child Neurology
Elizabeth Cecil, Alex Bottle, Richard Ma, Dougal S Hargreaves, Ingrid Wolfe, Arch G Mainous, Sonia Saxena
BACKGROUND: Universal health coverage (UHC) aims to improve child health through preventive primary care and vaccine coverage. Yet, in many developed countries with UHC, unplanned and ambulatory care sensitive (ACS) hospital admissions in childhood continue to rise. We investigated the relation between preventive primary care and risk of unplanned and ACS admission in children in a high-income country with UHC. METHODS: We followed 319,780 children registered from birth with 363 English practices in Clinical Practice Research Datalink linked to Hospital Episodes Statistics, born between January 2000 and March 2013...
September 17, 2018: BMC Medicine
Ronald J Swatzyna, Nash N Boutros, Ann C Genovese, Erin K MacInerney, Alexandra J Roark, Gerald P Kozlowski
Routine electroencephalograms (EEG) are not recommended as a screen for epileptic discharges (EDs) in current practice guidelines for children with autism spectrum disorder (ASD). However, a review of the research from the last three decades suggests that this practice should be reevaluated. The significant comorbidity between epilepsy and ASD, its shared biological pathways, risk for developmental regression, and cognitive challenges demand increased clinical investigation requiring a proactive approach. This review highlights and explains the need for screening EEGs for children with ASD...
September 14, 2018: European Child & Adolescent Psychiatry
Hana Kubová, Jaroslava Folbergrová, Jana Rejchrtová, Grygoriy Tsenov, Martina Pařízková, James Burchfiel, Anna Mikulecká, Pavel Mareš
Status epilepticus (SE), especially in immature animals, is known to produce recurrent spontaneous seizures and behavioral comorbidities later in life. The cause of these adverse long-term outcomes is unknown, but it has been hypothesized that free radicals produced by SE may play a role. We tested this hypothesis by treating immature (P25) rats with the free radical scavenger N-tert-butyl-α-phenylnitrone (PBN) at the time of lithium chloride (LiCl)/pilocarpine (PILO)-induced SE. Later, long-term outcomes were assessed...
2018: Frontiers in Cellular Neuroscience
Aytül Mutlu
OBJECTIVE: Similar clinical characteristics of epilepsy and migraine and the prevalence of their comorbidity have been investigated for years. The present study investigated the relationship between epilepsy and headache. METHODS: A total of 420 epilepsy patients, who visited epilepsy outpatient clinic within 6-month period between January 2016 and June 2016, were questioned whether they have headache. Age, gender, duration of epilepsy, type of seizures, and temporal relationship of headache with seizure were investigated in the patients with headache...
September 12, 2018: Neurological Sciences
Amanda Kahn, Gurmeen Kaur, Laura Stein, Stanley Tuhrim, Mandip S Dhamoon
BACKGROUND: International trials suggest benefit of revascularization surgery (RS) for moyamoya disease (MMD). However, nationally representative US data on demographics and outcomes after RS in MMD are lacking. AIMS: To estimate causes and rates of readmission after RS for MMD. METHODS: In the Nationwide Readmissions Database, index admissions for ECICB for MMD and readmissions for ischemic stroke (IS), subarachnoid hemorrhage (SAH), and intracerebral hemorrhage (ICH) were identified using validated International Classification of Diseases, Ninth Revision, Clinical Modification codes...
September 8, 2018: Journal of Neurology
Samuel Gittins, Dora Steel, Andreas Brunklaus, Imogen Newsom-Davis, Christina Hawkins, Sarah E Aylett
Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by the combination of a facial naevus flammeus and pial angioma, often associated with learning difficulties and/or epilepsy. Here, we report on the neuropsychological characteristics of a cohort of 92 children with SWS seen at a national referral center between 2002 and 2015. Almost a quarter (24%) had a diagnosis of autism spectrum disorder (ASD), with 45% overall having evidence of social communication difficulties (SCD). Autism spectrum disorder was more commonly seen in those individuals with bilateral angioma (p = 0...
September 6, 2018: Epilepsy & Behavior: E&B
Nhan Thi Ho, Barbara Kroner, Zachary Grinspan, Brandy Fureman, Kathleen Farrell, Jingzhou Zhang, Janice Buelow, Dale C Hesdorffer
OBJECTIVE: To describe the prevalence and characteristics of comorbidities in persons with rare epilepsies. STUDY DESIGN: Persons with rare epilepsies and caregivers of those affected were recruited through the Epilepsy Foundation and more than 30 rare epilepsy advocacy organizations affiliated with the Rare Epilepsy Network (REN). A web-based survey was conducted using a questionnaire consisting of core sections to collect data from affected persons on various aspects, including comorbidities...
September 5, 2018: Journal of Pediatrics
Susumu Morita, Go Taniguchi, Hidetaka Tamune, Yousuke Kumakura, Shinsuke Kondo, Kiyoto Kasai
Depressive disorders in epilepsy often present characteristic clinical manifestations atypical in primary, endogenous depression. Here, we report a case of a 64-year-old woman with right mesial temporal lobe epilepsy, who complained of bizarre, antipsychotic-refractory cenesthetic hallucinations in her interictal phase, and was hospitalized after a suicide attempt. Detailed clinical observations revealed mood symptoms, which led to the diagnosis of interictal dysphoric disorder comorbid with interictal psychosis...
2018: Epilepsy & Behavior Case Reports
Katarina Klobucnikova, Pavel Siarnik, Ivana Muchova, Juraj Štofko, Branislav Kollar
The aim of this study is to remind the possibility of co-occurrence of epilepsy and narcolepsy. In the first case report, narcolepsy type 1 was diagnosed in 29-year-old female. After one year of the treatment with modafinil a new episodes of automatic behavior appeared. Patient was reevaluated and the diagnosis of focal epilepsy with partial complex seizures was established. Patient was treated with modafinil and lamotrigine and became seizure-free. In the second case report a 21-year-old female was referred with a typical history of narcolepsy type 1, but also with atypical episodes of gazing and automatic behavior with amnesia for these episodes...
May 6, 2018: Neuro Endocrinology Letters
Stéphane Auvin, Elaine Wirrell, Kirsten A Donald, Madison Berl, Hans Hartmann, Kette D Valente, Patrick Van Bogaert, J Helen Cross, Makiko Osawa, Hideaki Kanemura, Masao Aihara, Marilisa M Guerreiro, Pauline Samia, Kollencheri Puthenveettil Vinayan, Mary Lou Smith, Lionel Carmant, Michael Kerr, Bruce Hermann, David Dunn, Jo M Wilmshurst
Attention-deficit/hyperactivity disorder (ADHD) is a common and challenging comorbidity affecting many children with epilepsy. A working group under the International League Against Epilepsy (ILAE) Pediatric Commission identified key questions on the identification and management of ADHD in children with epilepsy. Systematic reviews of the evidence to support approaches to these questions were collated and graded using criteria from the American Academy of Neurology Practice Parameter. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) requirements were followed, with PROSPERO registration (CRD42018094617)...
September 3, 2018: Epilepsia
Hiroto Iwasa, Reiko Hosaka, Sunao Kaneko
Psychiatric comorbidities, including mood, anxiety, psychotic disorders, and autism spectrum disorder are common in patients with epilepsy (PWE), often occurring at rates 2-3-fold or higher than in the general population without epilepsy. Furthermore, an attention should be paid to psychiatric symptoms together with those caused by antiepileptic drug therapy, epilepsy surgery, and vagus nerve stimulation because these therapies sometimes induce psychiatric comorbidities. It is important to differentiate psychogenic non epileptic seizures (PNES) from epilepsy, and to provide patients with psychiatric treatment...
September 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
Sandra Ventura, Márcio Rodrigues, Amílcar Falcão, Gilberto Alves
Citrus aurantium extracts have thermogenic and lipolytic activities and are largely used for weight loss/management. Once epilepsy and obesity are prevalent comorbid conditions and herb-drug interactions can compromise antiepileptic drugs safety, we aimed to evaluate the effects of C. aurantium extract on the pharmacokinetics of lamotrigine (LTG) in rats. In the first pharmacokinetic study, a single oral dose of C. aurantium extract (164 mg/kg; p.o.) was administered with a single oral dose of LTG (10 mg/kg; p...
August 30, 2018: Food and Chemical Toxicology
(no author information available yet)
BACKGROUND: The Sustainable Development Goals (SDGs) mandate systematic monitoring of the health and wellbeing of all children to achieve optimal early childhood development. However, global epidemiological data on children with developmental disabilities are scarce. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 provides a comprehensive assessment of prevalence and years lived with disability (YLDs) for development disabilities among children younger than 5 years in 195 countries and territories from 1990 to 2016...
October 2018: Lancet Global Health
Stoyan Popkirov, Jon Stone, Christopher P Derry
BACKGROUND: The aim of this study was to identify the prevalence of sleep disorders and measure the objective sleep quality in patients with seizure disorders. METHODS: Patients admitted for video electroencephalography monitoring were prospectively recruited and polysomnography was performed on the third night of monitoring. RESULTS: Four out of 44 (9%) epilepsy patients and 2/22 (9%) patients with dissociative seizures were found to have mild sleep-disordered breathing (SDB)...
August 31, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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