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sulfate magnesium nebulized

Zhantao Su, Rui Li, Zhongtao Gai
OBJECTIVE: This study aimed to evaluate the efficacy of intravenous (IV) and nebulized magnesium sulfate in acute asthma in children. METHODS: The PubMed, Cochrane Library, and EMBASE databases were searched. Randomized controlled trials and quasi-randomized controlled trials of IV and nebulized magnesium sulfate in pediatric acute asthma were included. The outcomes subject to meta-analysis were pulmonary function, hospitalization, and further treatment. If statistical heterogeneity was significant, random-effects models were used for meta-analysis, otherwise, fixed-effects models were applied...
October 4, 2016: Pediatric Emergency Care
Zhou-Gui Ling, Yan-Bin Wu, Jin-Liang Kong, Zhen-Ming Tang, Wei Liu, Yi-Qiang Chen
BACKGROUND: Nebulized magnesium sulfate (MgSO4) has been used to treat asthma, but the efficacy remains controversial. We aimed to comprehensively review the efficacy of nebulized MgSO4 in treating adult patients with asthma. METHODS: PubMed, Embase, and Cochrane Library were searched for relevant studies published up to July 18, 2016. Randomized controlled trials (RCTs) were included if adult patients with acute or stable asthma had been treated with nebulized MgSO4 compared with placebo or another bronchodilator...
September 17, 2016: Pulmonary Pharmacology & Therapeutics
Hatem A Sarhan, Omar H El-Garhy, Mohamed A Ali, Nouran A Youssef
OBJECTIVE: Evaluation of the efficacy of nebulized magnesium sulfate (MgSO4) alone and in combination with salbutamol in acute asthma. METHODS: A double-blind randomized controlled study was conducted in Chest and Emergency Departments. Thirty patients of acute attack of bronchial asthma were randomized into three groups: MgSO4 nebulization (group A), salbutamol nebulization (group B), and their combination (group C). All patients were monitored before and after nebulization (each 20 minutes) for peak expiratory flow rate (PEFR), respiratory rate (RR), heart rate (HR), blood pressure, pulsus paradoxus, oxygen saturation, clinical examination, and Fischl index...
2016: Drug Design, Development and Therapy
Monu Yadav, Nitish Chalumuru, Ramachandran Gopinath
BACKGROUND AND AIMS: Postoperative sore throat (POST) is a well-recognized complication after general anesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success. The present study was conducted to compare the efficiency of preoperative nebulization of normal saline and magnesium sulfate in reducing the incidence of POST following GA. MATERIALS AND METHODS: Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups...
April 2016: Journal of Anaesthesiology, Clinical Pharmacology
Suzanne Schuh, Judy Sweeney, Stephen B Freedman, Allan L Coates, David W Johnson, Graham Thompson, Jocelyn Gravel, Francine M Ducharme, Roger Zemek, Amy C Plint, Darcy Beer, Terry Klassen, Sarah Curtis, Karen Black, Darcy Nicksy, Andrew R Willan
BACKGROUND: Up to 30 % of children with acute asthma are refractory to initial therapy, and 84 % of this subpopulation needs hospitalization. Finding safe, noninvasive, and effective strategies to treat this high-risk group would substantially decrease hospitalizations, healthcare costs, and the psycho-social burden of the disease. Whereas intravenous magnesium (Mg) is effective in severe refractory asthma, its use is sporadic due to safety concerns, with the main treatment goal being to prevent intensive care unit admission...
May 24, 2016: Trials
Xiaoxi Liu, Tian Yu, Joseph E Rower, Sarah C Campbell, Catherine M T Sherwin, Michael D Johnson
BACKGROUND: Asthma is the most common pediatric chronic disease and currently affects 7.1 million children in the United States. Many children experience acute asthma exacerbations. Many children also require hospitalization despite treatment in an emergency department with current standard therapy (corticosteroids, albuterol, and ipratropium). These hospitalizations may be avoided if effective adjunctive therapies can be developed to adequately treat severe exacerbations. METHODS: Publications were searched in the PubMed database using the following keywords: magnesium AND asthma AND children AND randomized controlled trial...
May 24, 2016: Pediatric Pulmonology
Mohammad Reza Modaresi, Jamal Faghihinia, Roya Kelishadi, Mohsen Reisi, Shahrokh Mirlohi, Farhad Pajhang, Majid Sadeghian
In the original article, the authors failed to cite the study by Kose M et al. entitled "The efficacy of nebulized salbutamol, magnesium sulfate and salbutamol/magnesium sulfate combination in moderate bronchiolitis. Eur J Pediatr 2014;173: 1157-1160" as the first in literature to assess the efficacy of magnesium sulfate in the treatment of acute bronchiolitis. The authors apologize for this unintentional omission.
May 2016: Indian Journal of Pediatrics
Shaker Hossein, Akhavan Pegah, Farsi Davood, Abbasi Said, Mahshidfar Babak, Mofidi Mani, Rezai Mahdi, Hafezimoghadam Peyman
OBJECTIVE: Thirty percent of people with asthma do not respond to standard treatment, and complementary therapies are needed. The objective of this study was to investigate the impact of inhaled magnesium sulfate on the treatment response in emergency department (ED) patients with moderate to severe attacks of asthma. METHODS: This study is a randomized controlled trial, enrolling patients with moderate to severe asthma in the ED. Subjects allocated to the study group were treated with the standard, plus 3 ml of 260 mmol/L solution of magnesium sulfate every 20 to 60 minutes...
May 2016: American Journal of Emergency Medicine
Jose A Castro-Rodriguez, Gustavo J Rodrigo, Carlos E Rodríguez-Martínez
OBJECTIVE: The objective of this study is to summarize the principal findings in the literature about acute asthma management in children. METHODS: Systematic reviews of randomized clinical trials (SRCTs) with or without meta-analysis in children (1-18 years) admitted to the emergency department (ED) were retrieved using five data bases. Methodological quality was determined using the AMSTAR tool. RESULTS: One hundred and three studies were retrieved...
2015: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Anastassios C Koumbourlis, Christopher Mastropietro
To present the case of a patient with persistent bronchospasm, refractory to treatment with β2-agonists, that resolved promptly with continuous inhalation of large dose (1000 mcg/hr) ipratropium bromide, and to discuss the possibility of tolerance to β2-agonists as the cause for his failure to respond to adrenergic medications. The patient had received multiple doses of albuterol, as well as subcutaneous terbutaline (0.3 mg), intravenous magnesium sulfate (1 g) and intravenous dexamethasone (10 mg) prior to his admission to the intensive care unit...
January 2015: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Mohammad Reza Modaresi, Jamal Faghihinia, Roya Kelishadi, Mohsen Reisi, Shahrokh Mirlohi, Farhad Pajhang, Majid Sadeghian
OBJECTIVE: To assess the efficacy of nebulized magnesium sulfate as a bronchodilator in infants hospitalized with acute bronchiolitis. METHODS: This three-center double masked randomized clinical trial comprised 120 children with moderate to severe bronchiolitis. They were randomly assigned into two groups: the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg) and the second group (control) was treated with nebulized epinephrine (0...
September 2015: Indian Journal of Pediatrics
Khalid Alansari, Wessam Ahmed, Bruce L Davidson, Mohamed Alamri, Ibrahim Zakaria, Mahomud Alrifaai
BACKGROUND: Intravenous magnesium sulfate, a rescue therapy added to bronchodilator and systemic steroid therapy for moderate and severe asthma, is uncommonly administered. We hypothesized that nebulized magnesium would confer benefit without undue risk. DESIGN AND METHODS: Patients aged 2 to 14 y with moderate and severe asthma (PRAM severity score ≥ 4) admitted to infirmary/observation unit care were randomized double-blind on admission to receive 800 mg nebulized magnesium or normal saline placebo after all received intensive therapy with combined nebulized albuterol-ipratropium and intravenous methylprednisolone...
December 2015: Pediatric Pulmonology
Gustavo J Rodrigo
PURPOSE OF REVIEW: The purpose of this study is to highlight some of the recent findings related with the management of acute exacerbations in the context of the emergency department setting. RECENT FINDINGS: β₂-agonist heliox-driven nebulization significantly increased by 17% [95% confidence interval (CI) 5.2-29.4] peak expiratory flow, and decreased the rate of hospital admissions (risk ratio 0.77, 95% CI 0.62-0.98), compared with oxygen-driven nebulization...
January 2015: Current Opinion in Pulmonary Medicine
Stavros Petrou, Angela Boland, Kamran Khan, Colin Powell, Ruwanthi Kolamunnage-Dona, John Lowe, Iolo Doull, Kerry Hood, Paula Williamson
OBJECTIVES: The aim of this study was to estimate the cost-effectiveness of nebulized magnesium sulphate (MgSO4) in acute asthma in children from the perspective of the UK National Health Service and personal social services. METHODS: An economic evaluation was conducted based on evidence from a randomized placebo controlled multi-center trial of nebulized MgSO4 in severe acute asthma in children. Participants comprised 508 children aged 2-16 years presenting to an emergency department or a children's assessment unit with severe acute asthma across thirty hospitals in the United Kingdom...
October 2014: International Journal of Technology Assessment in Health Care
Fabiano Timbó Barbosa, Luciano Timbó Barbosa, Rafael Martins da Cunha, Giulliano Peixoto Gonçalves, Diego Agra de Souza
BACKGROUND AND OBJECTIVES: Magnesium sulfate has been shown to benefit asthmatic children and adults with poor responses to initial beta-agonist therapy and systemic corticoids in the emergency department. The aim of this study was to realize a no systematic review about the treatment of the acute asthma with intravenous and nebulized magnesium sulfate in the emergence. CONTENTS: The first investigations that demonstrate the benefit in the use of the magnesium sulfate in asthma date to 1938...
September 2007: Revista Brasileira de Terapia Intensiva
Hui Wang, Yi Xiong, Caihui Gong, Lijuan Yin, Li Yan, Xiaoping Yuan, Sha Liu, Tiantian Shi, Jihong Dai
OBJECTIVES: To determine the response of nebulized magnesium sulfate on the lung function of children with bronchial hyperresponsiveness. METHODS: Eighty-four children with asthma were divided into three groups randomly: magnesium sulfate (M), albuterol (A), and a combination of magnesium sulfate and albuterol (M + A). All patients were nebulized with acetylcholine, and then treated as designed. Lung function was compared between the three groups. RESULTS: Forced expiratory volume in first second (FEV1) significantly improved in all the three groups but it was better in (A) and (M + A) compared to (M) at 10 min and 20 min [10 min: 1...
April 2015: Indian Journal of Pediatrics
Steve Goodacre, Judith Cohen, Mike Bradburn, John Stevens, Alasdair Gray, Jonathan Benger, Tim Coats
BACKGROUND: Magnesium sulphate, administered by the intravenous (i.v.) or inhaled (nebulised) route, has been proposed as a treatment for adults with acute severe asthma. Existing trials show mixed results and uncertain evidence of benefit. OBJECTIVES: We aimed to determine whether i.v. or nebulised magnesium sulphate improves symptoms of breathlessness and reduces the need for hospital admission in adults with acute severe asthma. DESIGN: Multicentre, double-blind, placebo-controlled, three-arm, randomised trial...
April 2014: Health Technology Assessment: HTA
Mehmet Kose, Mehmet Adnan Ozturk, Hakan Poyrazoğlu, Tuba Elmas, Duygu Ekinci, Filiz Tubas, Tuba Kurt, Mehmet Akif Goktas
UNLABELLED: The aim of this paper is to compare the effect of nebulized magnesium sulfate to nebulized salbutamol and salbutamol/magnesium sulfate on successful discharge from the emergency department. A total of 56 infants were included in this double-blinded, prospective study. Infants were grouped according to the nebulized treatment they received: group 1-salbutamol/normal saline, group 2-magnesium sulfate and normal saline, and group 3-salbutamol plus magnesium sulfate. Heart beat, bronchiolitis, clinical severity scores (CSS), and oxygen saturation of the patients were determined before and after nebulization (0, 1, 4 h)...
September 2014: European Journal of Pediatrics
Alexander Wade, Christopher Chang
The heterogeneity of asthma is illustrated by the significantly different features of pediatric asthma compared to adult asthma. One phenotype of severe asthma in pediatrics includes atopy, lack of reduction in lung function, and absence of gender bias as the main characteristics. Included in the NIH NAEPP EPR-3 are recommendations for the treatment and management of severe pediatric asthma and critical asthma syndrome, such as continuous nebulization treatments, intubation and mechanical ventilation, heliox, and magnesium sulfate...
February 2015: Clinical Reviews in Allergy & Immunology
Steve Goodacre, Judith Cohen, Mike Bradburn, Alasdair Gray, Jonathan Benger, Timothy Coats
BACKGROUND: Previous studies suggested intravenous or nebulised magnesium sulphate (MgSO(4)) might improve respiratory function in patients with acute asthma. We aimed to determine whether intravenous or nebulised MgSO(4) improve symptoms of breathlessness and reduce the need for hospital admission in adults with severe acute asthma. METHODS: In our double-blind, placebo-controlled trial, we enrolled adults (aged ≥16 years) with severe acute asthma at emergency departments of 34 hospitals in the UK...
June 2013: Lancet Respiratory Medicine
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