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Behnaz Jarrahi, Katherine T Martucci, Aneesha S Nilakantan, Sean Mackey
Fibromyalgia is a multifaceted chronic pain condition of unknown etiology. Conditioned pain modulation (CPM) such as cold water pressor test of the foot, is widely documented as being disrupted in patients with fibromyalgia. To date, the mechanisms underlying such dysregulation of the descending control of pain in fibromyalgia remain poorly understood. In this study, we used ICA-based network analysis to comprehensively compare differences in functional network connectivity among relevant (nonartifactual) intrinsic connectivity brain networks during the resting state before and after cold pressor test in patients with fibromyalgia and healthy controls...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Dandan Wang, Jianbo Lai, Shaojia Lu, Manli Huang, Shaohua Hu, Yi Xu
RATIONALE: Hyponatremia following duloxetine treatment has been reported in patients with major depressive disorder, fibromyalgia, diabetic neuropathy, or sciatic pain. The manifestations of duloxetine-induced hyponatremia are varying in different individuals. The overall prognosis for this type of hyponatremia is favorable if properly managed. PATIENT CONCERNS AND DIAGNOSES: Herein, we reported rapid-onset hyponatremia and delirium in an older patient after 2 doses of duloxetine, which was used to control his postherpetic neuralgia...
November 2018: Medicine (Baltimore)
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Sonia Farah
Objective: To investigate the construct validity, reliability (internal consistency and retest reliability), and feasibility of the patient-reported outcomes thermometer-5-item scale (5T-PROs), a new tool to measure overall health status in patients with painful chronic rheumatic diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (axialSpA), and fibromyalgia (FM). Methods: Consecutive patients have been involved in this study...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
Fred Davis, Mark Gostine, Bradley Roberts, Rebecca Risko, Joseph C Cappelleri, Alesia Sadosky
Background: While fibromyalgia (FM) is characterized by chronic widespread pain and tenderness, its presentation among patients as a continuum of diseases rather than a single disease contributes to the challenges of diagnosis and treatment. The purpose of this analysis was to distinguish and characterize classes of FM within the continuum using data from chronic pain patients. Methods: FM patients were identified from administrative claims data from the ProCare Systems' network of Michigan pain clinics between January 1999 and February 2015...
2018: Journal of Pain Research
Ho-Jin Lee, Eunjoo Choi, Francis Sahngun Nahm, Seong-Soo Choi, Young-Hoon Kim, Jee Youn Moon, Shin Hyung Kim, Chan-Woo Cho, Pyung Bok Lee
Purpose: We aimed to investigate the prevalence of fibromyalgia (FM) in patients who visited outpatient pain clinics in Korea, using the modified 2010 American College of Rheumatology (ACR) criteria and to evaluate comorbid conditions that may be associated with FM. Patients and methods: Outpatients, aged ≥18 years, who first visited pain clinics at any of the 14 tertiary care university hospitals, were recruited for this study. Modified 2010 ACR criteria were used to diagnose FM...
2018: Journal of Pain Research
Mustafa Yassin, Amir Oron, Dror Robinson
OBJECTIVES: Low back pain (LBP) occurs in many patients with fibromyalgia (FM). The current study aimed to assess the possible pain and function amelioration associated with medical cannabis therapy (MCT) in this setting. METHODS: 31 patients were involved in an observational cross-over study. The patients were screened, treated with 3 months of standardised analgesic therapy (SAT): 5 mg of oxycodone hydrochloride equivalent to 4.5 mg oxycodone and 2.5 mg naloxone hydrochloride twice a day and duloxetine 30 mg once a day...
October 30, 2018: Clinical and Experimental Rheumatology
M Yolanda Castaño, Maria Garrido, Ana Beatriz Rodríguez, M Ángeles Gómez
BACKGROUND: Mood disturbances are implicated in the pathogenesis of fibromyalgia. The aim of this study was to assess the effect of different doses of melatonin on quality of life, mood status, pain, anxiety, and urinary cortisol levels in patients with fibromyalgia. METHODS: After a 10-day baseline period for the collection of data about participants' initial status, participants took different doses of melatonin for 10 consecutive days each, with placebo given during the 10 days either before or between melatonin doses...
November 11, 2018: Biological Research for Nursing
Noam Goldway, Jacob Ablin, Omer Lubin, Yoav Zamir, Jackob Nimrod Keynan, Ayelet Or-Borichev, Marc Cavazza, Fred Charles, Nathan Intrator, Silviu Brill, Eti Ben-Simon, Haggai Sharon, Talma Hendler
Volitional neural modulation using neurofeedback has been indicated as a potential treatment for chronic conditions that involve peripheral and central neural dysregulation. Here we utilized neurofeedback in patients suffering from Fibromyalgia - a chronic pain syndrome that involves sleep disturbance and emotion dysregulation. These ancillary symptoms, which have an amplification effect on pain, are known to be mediated by heightened limbic activity. In order to reliably probe limbic activity in a scalable manner fit for EEG-neurofeedback training, we utilized an Electrical Finger Print (EFP) model of amygdala-BOLD signal (termed Amyg-EFP), that has been successfully validated in our lab in the context of volitional neuromodulation...
November 5, 2018: NeuroImage
Takako Miyamae, Yukihide Chiba, Ikuko Kato, Yumi Tani, Hisashi Yamanaka
No abstract text is available yet for this article.
November 8, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Alessia Alunno, Francesco Carubbi, Simon Stones, Roberto Gerli, Roberto Giacomelli, Xenofon Baraliakos
The term spondyloarthritis (SpA) encompasses a broad clinical spectrum characterized by chronic inflammatory conditions affecting the sacroiliac joints, the spine but also peripheral joints and tendons and being additionally associated with the involvement of organs, such as bowel, eye and skin (1). Musculoskeletal pain is a key symptom in SpA. However, although low back pain and/or joint pain are characteristic for SpA, undifferentiated pain at different enthesial sites may also be a concomitant or even the first clinical presentation in some patients (2)...
2018: Frontiers in Medicine
Ruth F Itzhaki
Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer's disease (AD). This concept proposes that latent HSV1 in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE-ε4) is reactivated intermittently by events such as immunosuppression, peripheral infection, and inflammation, the consequent damage accumulating, and culminating eventually in the development of AD. Population data to investigate this epidemiologically, e...
2018: Frontiers in Aging Neuroscience
J M Gomez-Arguelles, C Maestu-Unturbe, E J Gomez-Aguilera
INTRODUCTION: Most current research suggests that fibromyalgia is a disease produced by an alteration in the processing of pain signals in the central nervous system. In recent years, advances in non- or minimally-invasive brain imaging techniques have made it possible to discover how different areas of the nervous system are involved in the aetiopathogenesis of diseases that up until now have been considered as having a functional profile. AIM: To describe the objectified functional and the structural changes that take place in the brains of patients with fibro-myalgia by means of the currently available neuroimaging techniques...
November 16, 2018: Revista de Neurologia
Resul Yılmaz, Damlanur Üstün, Sema Tuncer Uzun, Ruhiye Reisli, Şeyda Türk
Tardive dyskinesia and tardive dystonia are caused by dopamine receptor blocking agents, mostly antipsychotics and sometimes antidepressants or calcium channel blockers. Duloxetine is a serotonin-noradrenaline reuptake inhibitor used in the treatment of diabetic neuropathic pain and fibromyalgia, as well as major depression. In this case, we aimed to discuss the tardive dyskinesia-like appearance of a patient using duloxetine due to fibromyalgia.
October 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
Yuichiro Honda, Junya Sakamoto, Yohei Hamaue, Hideki Kataoka, Yasutaka Kondo, Ryo Sasabe, Kyo Goto, Takuya Fukushima, Satoshi Oga, Ryo Sasaki, Natsumi Tanaka, Jiro Nakano, Minoru Okita
Purpose: We conducted a systematic review and meta-analysis to investigate the effects of the following physical-agent modalities for pain relief in fibromyalgia (FM) patients. Methods: We identified randomized controlled studies of adults with FM in the MEDLINE, CINAHL, and PEDro databases. The primary outcome measure was pain relief measured by a visual analogue scale (VAS), and the secondary outcome measures of interest were subjective improvements in the number of tender points, Fibromyalgia Impact Questionnaire (FIQ), and quality of life (QOL) scores...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
Kholoud M El-Shewy, Ahmad Kunbaz, Mohamed M Gad, Muneer J Al-Husseini, Anas M Saad, Yasser M Sammour, Mohamed M Abdel-Daim
Chronic pain is one of the most common clinical presentations in the primary care settings. In the US, Fibromyalgia (FM) affects about 1-3% of adults and commonly occurs in adults between the ages of 40-50 years. FM causes widespread muscular pain and tenderness with hyperalgesia and allodynia and may be associated with other somatic complaints. Hyperbaric oxygen therapy (HBOT) has been utilized and has recently shown promising effects in the management of FM and other chronic pain disorders. In HBOT, the intermittent breathing of 100% oxygen in a pressurized chamber where the pressure is higher than 1 atmosphere absolute (ATA) has been utilized...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Charles Van Liew, Karissa Standridge, Gabriel Leon, Terry A Cronan
AIM: To evaluate pain experiences and memories in fibromyalgia (FM) patients over time. METHOD: Participants included 572 females who were members of a large health maintenance organization who had a diagnosis of FM syndrome (FMS) and met inclusion criteria for the study. Recruitment was for an intervention study that tested the effects of social support and education treatment arms, but there were no treatment effects. Reports of experiential pain (EP), historical peak pain (HPP), and historical valley pain (HVP) for FM were collected...
November 5, 2018: International Journal of Rheumatic Diseases
Swati Mehta, Vanessa A Peynenburg, Heather D Hadjistavropoulos
This systematic review and meta-analysis aims to evaluate the effectiveness of internet-delivered cognitive behavioural therapy (ICBT) on anxiety and depression among persons with chronic health conditions. A systematic database search was conducted of MEDLINE, CINAHL, PsycInfo, EMBASE, and Cochrane for relevant studies published from 1990 to September 2018. A study was included if the following criteria were met: (1) randomized controlled trial involving an ICBT intervention; (2) participants experienced a chronic health condition; (3) participants ≥ 18 years of age; and (4) effects of ICBT on anxiety and/or depression were reported...
November 1, 2018: Journal of Behavioral Medicine
Justin N Siemian, Li Shang, Robert W Seaman, Qing Zhu, Yanan Zhang, Jun-Xu Li
Pharmacotherapies for fibromyalgia treatment are lacking. This study examined the antinociceptive and antidepressant-like effects of imidazoline I2 receptor (I2R) agonists in a reserpine-induced model of fibromyalgia in rats. Rats were treated for 3 days with vehicle or reserpine. The von Frey filament test was used to assess the antinociceptive effects of I2 receptor agonists, and the forced swim test was used to assess the antidepressant-like effects of these drugs. 2-BFI (3.2-10 mg/kg, intraperitoneally), phenyzoline (17...
October 31, 2018: Behavioural Pharmacology
Safinaz Ataoglu, Handan Ankarali, Rumeysa Samanci, Mustafa Ozsahin, Ozlem Admis
OBJECTIVE: The aim of this study was to investigate whether there is a correlation between serum leptin level, disease activity and inflammation markers in patients with fibromyalgia syndrome (FMS). METHODS: A total of 48 patients with FMS diagnosed according to the 1990 American College of Rheumatology criteria were included in the study, as well as 36 healthy women as controls. The Visual Analogue Scale was used to gauge pain severity, the Fibromyalgia Impact Questionnaire was used to assess physical function, the 36-Item Short Form Health Survey was used to examine quality of life, and depression was measured with the Beck Depression Inventory...
2018: Northern Clinics of Istanbul
Wai Sze Chan, Meredith P Levsen, Svyatoslav Puyat, Michael E Robinson, Roland Staud, Richard B Berry, Christina S McCrae
STUDY OBJECTIVES: Individuals with primary insomnia often have poorer self-reported sleep than objectively measured sleep, a phenomenon termed negative sleep discrepancy. Recent studies suggest that this phenomenon might differ depending on comorbidities. This study examined sleep discrepancy, its night-to-night variability, and its correlates in comorbid insomnia and fibromyalgia. METHODS: Sleep diaries and actigraphy data were obtained from 223 adults with fibromyalgia and insomnia (age = 51...
October 24, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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