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Tetsuo Kiso, Toshihiro Sekizawa, Hiroshi Uchino, Mina Tsukamoto, Shuichiro Kakimoto
BACKGROUND AND PURPOSE: Glucocorticoids are a major class of stress hormones that have been reported to participate in stress-induced hyperalgesia. Although 11β-hydroxysteroid dehydrogenase1 (11β-HSD1) is known to be a key enzyme in the intracellular regeneration of glucocorticoids in the central nervous system (CNS), its role in pain perception has not been elucidated. Here, we examined the effects of ASP3662, a novel 11β-HSD1 inhibitor, on neuropathic and dysfunctional pain. EXPERIMENTAL APPROACH: The enzyme inhibitory activities and pharmacokinetics of ASP3662 were examined, and its antinociceptive effects were evaluated in neuropathic pain, fibromyalgia, and inflammatory pain rat models...
July 14, 2018: British Journal of Pharmacology
Sherifa Ahmed Hamed
OBJECTIVES: Pregabalin (PGB) is a gabapentinoid (ie, GABA analog), which has been Food and Drug Administration-approved for treatment of partial epilepsy in adults and neuropathic pain. It also has off-label uses for the treatment of generalized anxiety disorders, fibromyalgia, and tension headache and prevention of migraine. Few cases were reported with sexual dysfunctions (SDs) as adverse effects of PGB and gabapentin, and the majority were dose related (≥900 mg/d for gabapentin)...
July 2018: Clinical Neuropharmacology
Paul E Hilliard, Jennifer Waljee, Stephanie Moser, Lynn Metz, Michael Mathis, Jenna Goesling, David Cron, Daniel J Clauw, Michael Englesbe, Goncalo Abecasis, Chad M Brummett
Importance: Patterns of preoperative opioid use are not well characterized across different surgical services, and studies in this patient population have lacked important self-reported data of pain and affect. Objectives: To assess the prevalence of preoperative opioid use and the characteristics of these patients in a broadly representative surgical cohort. Design, Setting, and Participants: Cross-sectional, observational study of patients undergoing surgery at a tertiary care academic medical center...
July 11, 2018: JAMA Surgery
Jacoline J van den Driest, Patrick Pijnenburg, Patrick J E Bindels, Sita M A Bierma-Zeinstra, Dieuwke Schiphof
OBJECTIVE: The aim of this study was to examine which analgesics are used by patients with osteoarthritis (OA)-related pain and how the analgesics are used in the preceding month. In addition, their beliefs about (pain) medication and the rationale of those declining to use analgesics were explored. METHODS: An online cross-sectional survey was sent to 1521 patients participating in the panel of the Dutch Arthritis Foundation. Descriptive analyses and logistic regression were used to analyze data...
July 10, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Didem Gokcay, Aykut Eken, Serdar Baltaci
Among several features used for clinical binary classification, behavioral performance, questionnaire scores, test results and physical exam reports can be counted. Attempts to include neuroimaging findings to support clinical diagnosis are scarce due to difficulties in collecting such data, as well as problems in integration of neuroimaging findings with other features. The binary classification method proposed here aims to merge small samples from multiple sites so that a large cohort which better describes the features of the disease can be built...
June 5, 2018: IEEE Journal of Biomedical and Health Informatics
Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa
Background: Yokukansan (YKS), a traditional herbal (Kampo) medicine consisting of seven herbs, is effective in the treatment of pain disorders, such as headache, postherpetic neuralgia, fibromyalgia, and trigeminal neuralgia, and we have previously shown it to be effective against morphine analgesic tolerance in rats. It has been reported that orexin receptor antagonists prevent the development of morphine tolerance and that YKS inhibits the secretion of orexin A in the hypothalamus. This study examined whether the inhibition of the secretion of orexin A by YKS is one mechanism underlying its effect against morphine analgesic tolerance...
June 2018: Integrative Medicine Research
Nayereh Ghoreishi-Haack, Jessica M Priebe, Jacqueline D Aguado, Elizabeth M Colechio, Jeffrey S Burgdorf, M Scott Bowers, Cassia N Cearley, M Amin Khan, Joseph R Moskal
NYX-2925 is a novel N-methyl-D-aspartate (NMDA) receptor modulator that is currently being investigated in Phase 2 clinical studies for the treatment of painful diabetic peripheral neuropathy and fibromyalgia. Previous studies demonstrated that NYX-2925 is a member of a novel class of NMDA receptor-specific modulators that affect synaptic plasticity processes associated with learning and memory. Studies here examined thermal and mechanical analgesic effects of NYX-2925 administration in rat peripheral chronic constriction nerve injury (CCI) and streptozotocin (STZ)-induced diabetic mechanical hypersensitivity...
July 9, 2018: Journal of Pharmacology and Experimental Therapeutics
Carolina P Andrade, Antonio R Zamunér, Meire Forti, Nayara Y Tamburús, Ester Silva
BACKGROUND: Aquatic physical training (APT) promotes improvement of clinical symptoms and aerobic functional capacity in women with fibromyalgia syndrome (FMS). However, there are controversial studies that refer to the maintenance of adaptations obtained from APT after a detraining period. AIM: To evaluate variables oxygen uptake (VO2) relative to lean body mass (LBM) and clinical symptomatology in women with FMS submitted to APT and after 16 weeks of detraining period, and to evaluate the association between the magnitude of VO2 improvement relative to LBM and clinical symptomatology...
July 6, 2018: European Journal of Physical and Rehabilitation Medicine
K Bernardy, P Klose, P Welsch, W Häuser
BACKGROUND AND OBJECTIVE: This systematic review aimed at evaluating the efficacy, acceptability and safety of internet-based psychological therapies (IPTs) in fibromyalgia syndrome (FMS). DATABASES AND DATA TREATMENT: Cochrane Library, MEDLINE, PsycINFO and SCOPUS were searched from inception to January 2018. Randomized controlled trials (RCTs) comparing IPTs with controls were analysed. Primary outcomes were ≥ 50% pain relief, disability, negative mood, acceptability and safety at end of therapy and at six months follow up...
July 8, 2018: European Journal of Pain: EJP
Tobias Romeyke, Elisabeth Noehammer, Harald Stummer
Patients with fibromyalgia (FM) have often tried many outpatient treatments, and breakthrough pain frequently stops them from performing everyday tasks and participating in society. FM-pain that has become chronic, therefore, affects quality of life. This case study describes the administration of interdisciplinary inpatient pain therapy due to a primary diagnosis of fibromyalgia with integrated complementary medicine. The female patient, who had several concomitant disorders and had been suffering from pain for many years, benefited from the holistic treatment approach in terms of a reduction in pain and an improvement in physical functions and mental health...
June 2018: Integrative Medicine Research
Yukinori Nagakura, Nana Ohsaka, Ryutarou Azuma, Saeri Takahashi, Yuuka Takebayashi, Saori Kawasaki, Shuhei Murai, Masaya Miwa, Hiroko Saito
Functional somatic syndromes (FSS), a clinical condition manifesting a variety of unexplained somatic symptoms, has been proposed as an inclusive nosology encompassing individual syndromes such as fibromyalgia syndrome and irritable bowel syndrome. Accumulating evidence suggests that disturbance of the endogenous monoamine system could be involved in the aetiology of FSS. Therefore, the purpose of present study was to investigate whether the disturbance of the monoamine system would cause FSS-associated symptomatology in mice...
July 4, 2018: Physiology & Behavior
Jérémy Lambert, Michael Chekroun, Hélène Gilet, Catherine Acquadro, Benoit Arnould
BACKGROUND: Patients with chronic conditions are required to take long-term treatments for their disease itself or to prevent any potential health risks. Measuring patient acceptance of their medication should help to better understand and predict patients' behavior toward treatment. This study aimed to describe the level of patient acceptance toward various long-term treatments in real life using an online patient community. METHODS: This was an observational, cross-sectional study conducted through the French Carenity platform...
July 6, 2018: Health and Quality of Life Outcomes
Olga Gelonch, Maite Garolera, Joan Valls, Gerard Castellà, Olalla Varela, Lluís Rosselló, Josep Pifarre
BACKGROUND: Fibromyalgia (FM) patients frequently complain of cognitive problems, but it remains unclear whether these cognitive complaints can be attributed to a dysfunction of the central nervous system or if they can be explained by other factors associated with the disease, such as depression, anxiety and sleep dysfunction. METHODS: One hundred and ten patients with FM were compared with thirty-three patients diagnosed with a depressive disorder (DD) and fifty healthy controls (HC)...
2018: PloS One
Carolina Sitges, Ana M González-Roldán, Stefan Duschek, Pedro Montoya
OBJECTIVES: Comorbid symptoms in fibromyalgia syndrome (FM), such as mood disorders and cognitive dysfunction, may lead to greater functional impairment than pain itself. This study aimed to unravel the modulating role of depression in response execution and inhibition in FM using an emotional go/no-go task. METHODS: Seventeen FM patients with low depression, 18 FM patients with high depression, and 18 pain-free subjects were selected. Pain, happy and neutral faces were pseudorandomly presented and subjects were asked to respond to male faces (go trials) by pressing a button, and to inhibit their responses if female faces were presented (no-go trials)...
July 2, 2018: Clinical Journal of Pain
Maria Dolores Carrillo-Izquierdo, Mahmoud Slim, Javier Hidalgo-Tallon, Elena P Calandre
AIMS: To evaluate the prevalence, distress, and impact of pelvic floor dysfunction (PFD) symptomatology in women with fibromyalgia and control women. We also aimed to evaluate the impact of PFD symptomatology on several psychosocial measures such as mood, sleep, pain, and quality of life. METHODS: We conducted a cross-sectional study in women with fibromyalgia and control women from the general population. Using a structured survey, we collected sociodemographic and clinical data, assessed the prevalence of PFD and evaluated the distress (PFDI-20) and the impact (PFIQ-7) caused by its symptomatology...
July 4, 2018: Neurourology and Urodynamics
Monika Vij, Anthony Davies, Anu Dua, Robert Freeman
INTRODUCTION AND HYPOTHESIS: Patients in gynecology outpatient clinics (GOPDs) may present with symptoms that do not correlate well with the observed pathology and are usually labelled as having a functional disorder or medically unexplained symptoms (MUS). Underlying central sensitivity syndrome (CSS) with central sensitization (CS) as a potential mechanism may be responsible for some of their symptoms. The aim of this study is to identify the proportion of women with central sensitivity syndrome attending GOPDs...
July 4, 2018: International Urogynecology Journal
Mikito Hirakata, Satomi Yoshida, Sachiko Tanaka-Mizuno, Aki Kuwauchi, Koji Kawakami
Objective: To assess dose, characteristics, and coprescribed analgesics in patients newly prescribed pregabalin for neuropathic pain and fibromyalgia in Japan. Methods: Based on the medical and prescription information present in the Medical Data Vision database, we analyzed the initial and maximum daily doses, prescription period, coprescribed analgesics, and neuropathic pain-related disorders of patients newly prescribed pregabalin between 01 July 2010 and 31 December 2013...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
Ozlem Balbaloglu, Nermin Tanik, Mahmut Alpayci, Hakan Ak, Elif Karaahmet, Levent Ertugrul Inan
AIM: Paresthesia and personality disorders are common conditions among patients with fibromyalgia. However, no previous study has examined a possible relation of paresthesia with personality traits in fibromyalgia. This study investigates the frequency of paresthesia in fibromyalgia patients and its relation with personality traits. METHOD: Female patients with fibromyalgia (n = 101) were divided into two groups according to the presence (n = 49; mean age 40...
July 2018: International Journal of Rheumatic Diseases
Alessandro Chiarotto, Carlotta Viti, Alberto Sulli, Maurizio Cutolo, Marco Testa, Daniele Piscitelli
BACKGROUND: Central sensitization (CS) is an important feature in patients with chronic pain. The Central Sensitization Inventory (CSI) was developed with the goal of detecting the patients' symptoms related to CS. OBJECTIVES: This study aimed at cross-culturally adapting the CSI into Italian, and at assessing its structural and construct validity in patients with different chronic pain disorders. DESIGN: Clinimetric study. METHODS: The Italian version of the CSI (CSI-I) was generated following forward and backward translations, expert committee review, and pilot-testing...
June 15, 2018: Musculoskeletal Science & Practice
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Piercarlo Sarzi-Puttini
To determine the contribution of fibromyalgia (FM) to the subjective components of the Disease Activity Score 28-joints (DAS28) in patients with rheumatoid arthritis (RA), and to analyse the discriminatory performance of the derived DAS28 patient-reported components (DAS28-P) to identify patients with fibromyalgic RA. Consecutive RA patients underwent clinical and clinimetric assessment. The DAS28-P index was derived from the components of the DAS28 scores by rearranging the DAS28-ESR formula. Patients were distinguished by the presence of FM...
June 28, 2018: Rheumatology International
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