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Tumor necrosis factor and neonates

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https://www.readbyqxmd.com/read/27916093/-protective-effect-of-interleukin-22-against-hyperoxia-induced-lung-injury-in-neonatal-rats
#1
Li Yuan, Xiuxiang Liu, Ruiwei Gao, Jinshuai Ma, Suni Lu, Haihong Zhang
Objective To study the protective effect of interleukin-22 (IL-22) against the hyperoxia-induced lung injury in neonatal SD rats. Methods The neonatal SD rats were randomized into control group, hyperoxia group and IL-22 (10 ng/g) treatment group. Each group was randomly divided into three subgroups of 1, 3, 7 days (n=9). Body mass in every group was detected; lung pathological changes were observed by HE staining; tumor necrosis factor α (TNF-α) in lung tissues was tested by quantitative real-time PCR; and IL-1β in plasma was measured by ELISA...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27913060/outcome-of-pregnancy-and-neonatal-complications-with-anti-tumor-necrosis-factor-%C3%AE-use-in-females-with-immune-mediated-diseases-a-systematic-review-and-meta-analysis
#2
REVIEW
Fukiko Komaki, Yuga Komaki, Dejan Micic, Akio Ido, Atsushi Sakuraba
BACKGROUND: Immune mediated diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), and inflammatory bowel disease (IBD) commonly affect young and adolescent females. Anti-tumor necrosis factor (TNF)-α agents are increasingly used to treat these conditions, but their safety during pregnancy remains unclear. OBJECTIVES: To evaluate the risk of pregnancy related outcomes in patients with various immune mediated diseases treated with anti-TNF-α agents...
November 29, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27871914/neonatal-levels-of-adiponectin-interleukin-10-and-interleukin-12-are-associated-with-the-risk-of-developing-type-1-diabetes-in-childhood-and-adolescence-a-nationwide-danish-case-control-study
#3
Steffen U Thorsen, Christian B Pipper, Stefanie Eising, Kristin Skogstrand, David M Hougaard, Jannet Svensson, Flemming Pociot
BACKGROUND/AIM: An in-depth understanding of the early phase of type 1 diabetes (T1D) pathogenesis is important for targeting primary prevention. We examined if 14 preselected mediators of immune responses differed in neonates that later developed T1D compared to control neonates. METHODS: The study is a case-control study with a 1:2 matching. The individuals were born between 1981 through 2002. Cases were validated using the National Patient Register and the Danish Childhood Diabetes Register...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27854156/demonstration-of-physicochemical-and-functional-similarity-between-the-proposed-biosimilar-adalimumab-msb11022-and-humira%C3%A2
#4
Laurent Magnenat, Angelo Palmese, Christèle Fremaux, Fabio D'Amici, Mariagrazia Terlizzese, Mara Rossi, Laurent Chevalet
Biosimilars are biological products that are highly similar to existing products approved by health authorities. Demonstration of similarity starts with the comprehensive analysis of the reference product and its proposed biosimilar at the physicochemical and functional levels. Here, we report the results of a comparative analysis of a proposed biosimilar adalimumab MSB11022 and its reference product, Humira®. Three batches of MSB11022 and up to 23 batches of Humira® were analyzed by a set of state-of-the-art orthogonal methods...
November 17, 2016: MAbs
https://www.readbyqxmd.com/read/27849634/inflammation-and-apoptosis-dual-mediator-role-for-toll-like-receptor-4-in-the-development-of-necrotizing-enterocolitis
#5
Yin Zhou, Yibo Li, Bin Zhou, Keling Chen, Zhaoying Lyv, Dongmei Huang, Bin Liu, Zhicheng Xu, Bo Xiang, Shuguang Jin, Xiaofeng Sun, Yuan Li
BACKGROUND: Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal mortality; effective interventions are lacking with limited understanding of the pathogenesis of NEC. The importance of Toll-like receptor 4 (TLR4) signaling in NEC is well documented; however, the potential mechanisms that regulate enterocyte inflammation and apoptosis remain unclear. The aim of this study was to characterize the role of TLR4-mediated inflammation and apoptosis in the development of NEC and to determine the major apoptotic pathways and regulators in the process...
November 14, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27793739/globular-ctrp3-promotes-mitochondrial-biogenesis-in-cardiomyocytes-through-ampk-pgc-1%C3%AE-pathway
#6
Cheng-Lin Zhang, Han Feng, Li Li, Jin-Yu Wang, Dan Wu, Yan-Ting Hao, Zheng Wang, Yan Zhang, Li-Ling Wu
BACKGROUND: Mitochondrial biogenesis is crucial for the maintenance of mitochondrial function and cellular homeostasis. C1q/tumor necrosis factor-related protein-3 (CTRP3) is an adipokine that owns multiple functions on metabolic and cardiovascular diseases. However, whether CTRP3 affects mitochondrial biogenesis in cardiomyocytes remains unknown. METHODS: Neonatal rat ventricular myocytes were cultured and treated with globular CTRP3 (gCTRP3). The expression of mitochondrial biogenesis related genes was measured by real-time PCR and western blot analysis...
October 26, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27648693/multiplex-cytokine-profiling-identifies-interleukin-27-as-a-novel-biomarker-for-neonatal-early-onset-sepsis
#7
Yu He, Wei Xia Du, Hong Yan Jiang, Qing Ai, Jinxing Feng, Zhengqiu Liu, Jia Lin Yu
BACKGROUND: Early onset sepsis (EOS) remains a major cause of mortality and morbidity in neonates, and traditional clinical markers effective for adults are less effective in these patients. This study aimed to assess the value of individual plasma biomarkers as well as biomarker combinations for predicting EOS in neonates. METHODS: This prospective study included 151 neonates with suspected EOS. Plasma levels of interleukin (IL)-27, IL-6, IL-8, tumor necrosis factor (TNF)-α, heat shock protein (HSP) 70, macrophage inflammatory protein (MIP)-1α, MIP-1β, granzyme B, and matrix metalloproteinase (MMP)-8 were measured through multiplex cytokine profiling and assessed along with C-reactive protein (CRP) and procalcitonin (PCT)...
September 19, 2016: Shock
https://www.readbyqxmd.com/read/27645622/atorvastatin-alleviates-cardiomyocyte-apoptosis-by-suppressing-trb3-induced-by-acute-myocardial-infarction-and-hypoxia
#8
Wen-Pin Cheng, Huey-Ming Lo, Bao-Wei Wang, Su-Kiat Chua, Ming-Jen Lu, Kou-Gi Shyu
BACKGROUND/PURPOSE: TRB3 (tribbles 3), an apoptosis-regulated gene, increases during endoplasmic reticulum stress. Hypoxia can induce inflammatory mediators and apoptosis in cardiomyocytes. However, the expression of TRB3 in cardiomyocyte apoptosis under hypoxia is not thoroughly known. We investigated the regulation mechanism of TRB3 expression and apoptosis induced by hypoxia in cardiomyocytes. METHODS: An in vivo model of acute myocardial infarction (AMI) was applied in adult Wistar rats to induce myocardial hypoxia...
September 16, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27616300/neuroprotective-effects-of-hypothermia-in-inflammatory-sensitized-hypoxic-ischemic-encephalopathy
#9
Mathilde Chevin, Clémence Guiraut, Caroline Maurice-Gelinas, Jessica Deslauriers, Sylvain Grignon, Guillaume Sébire
BACKGROUND: Despite the recent introduction of hypothermia as a mandatory standard of care, the incidence of neonatal encephalopathy in full-term newborns and its devastating neuro-behavioral outcomes continues to be a major individual, familial and social issue. Neonatal encephalopathy is mainly due to the compounding and interacting effects of hypoxia-ischemia and inflammation resulting from placental and other perinatal infections. It is unclear why hypothermia is effective in alleviating neonatal encephalopathy in some, but not all, full-term newborns...
September 9, 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27613478/amelioration-of-brain-damage-by-glycine-in-neonatal-rat-brain-following-hypoxia-ischemia
#10
Hiroko Mori, Ken Momosaki, Jun Kido, Tetsuo Naramura, Kenichi Tanaka, Shirou Matsumoto, Kimitoshi Nakamura, Hiroshi Mitsubuchi, Fumio Endo, Masanori Iwai
BACKGROUND: Glycine protected adult brains against injury in an experimental model of stroke. However, because the ischemic response of neonatal brains differs from that of adult brains, we examined the neuroprotective efficacy of glycine and associated mechanisms in an experimental model of neonatal hypoxic-ischemic (HI) encephalopathy. METHODS: Neonatal (P7) Wister rats were randomly divided into an untreated group (non-HI) and two HI groups that were treated with left common carotid artery ligation and saline control or glycine...
September 10, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27590984/toll-like-receptor-7-agonist-induces-hypoplasia-of-the-biliary-system-in-a-neonatal-mouse-model
#11
Ying-Hsien Huang, Hsiang-Hung Shih, Mao-Meng Tiao, Chao-Cheng Huang, Kuang-Che Kuo, Fu-Chen Huang, Ya-Ling Yang, Jiin-Haur Chuang
BACKGROUND/PURPOSE: Viral infections and innate immunity signaling, especially Toll-like receptor 7 (TLR7) have been implicated in the pathogenesis of biliary atresia (BA). Administration of rhesus rotavirus-type A to newborn Balb/c mice produces inflammatory obstruction of bile ducts, which resembles human BA. However, whether activation of TLR7 signaling plays a role in neonatal hepatobiliary injury remains to be investigated. METHODS: TLR7 agonist, imiquimod (R837), was intraperitoneally administered to Balb/c mice within 24 hours of birth and then every other day...
August 3, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/27588096/non-intervention-observation-dynamic-evolution-laws-of-inflammatory-response-in-necrotizing-enterocolitis
#12
Wei Wang, Li Xue, Tongsheng Ma, Yuan Li, Zhenguang Li
The pathogenesis of necrotizing enterocolitis (NEC) is not well understood but immunological factors are thought to be key determinants of the disease appearance and its prognosis. During the course of the present study, different groups of newborn infants were observed and tested, to obtain an accurate image of values of pro- and anti-inflammatory cytokines at the onset, development and progression of neonatal NEC and to compare the values to those obtained during normal healthy development. All the infants in the study received standard medical treatment as appropriate...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27572468/naringenin-pre-treatment-inhibits-neuroapoptosis-and-ameliorates-cognitive-impairment-in-rats-exposed-to-isoflurane-anesthesia-by-regulating-the-pi3-akt-pten-signalling-pathway-and-suppressing-nf-%C3%AE%C2%BAb-mediated-inflammation
#13
Fu-Zhou Hua, Jun Ying, Jing Zhang, Xi-Feng Wang, Yan-Hui Hu, Ying-Ping Liang, Qin Liu, Guo-Hai Xu
The volatile anaesthetic isoflurane is one of the most frequently employed general anaesthetics in neonates, children and adults. Accumulating evidence demonstrated that exposure to anaesthetics is associated with widespread neurodegeneration and cognitive impairment. Thus, the identification and development of compounds capable of preventing or reducing these adverse effects is of great clinical importance. For this purpose, the present study aimed to assess the effects of a flavonoid, naringenin, on isoflurane-induced neuroapoptosis and cognitive impairment...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27515290/helium-preconditioning-protects-the-brain-against-hypoxia-ischemia-injury-via-improving-the-neurovascular-niche-in-a-neonatal-rat-model
#14
Yi Li, Peixi Zhang, Ying Liu, Wenwu Liu, Na Yin
This study aimed to investigate whether helium preconditioning (He-PC) is able to exert neuroprotective effects via improving focal neurovascular niche in a neonatal rat hypoxia/ischemia (HI) brain injury model. Seven day old rat pups were divided into control group, HI group and He-PC group. HI was induced by exposure to 8% oxygen for 90min one day after preconditioning with 70% helium-30% oxygen for three 5-min periods. At 3 and 7 days, the brain was collected for the detection of inflammation related factors (tumor necrosis factor α [TNF-α], interleukin-1β [IL-1β], IL-10) and growth/neurotrophic factors (brain-derived neurotrophic factor [BDNF], basic fibroblast growth factor [bFGF] and nerve growth factor [NGF]); at 7 days, neurobehaviors were evaluated, and the brain was collected for the detection of mRNA expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) by PCR, protein expression of angiogenesis related molecules (VEGF, Ang-1, Tie-2 and Flt-1) by Western blotting and microvessel density (MCD) by immunohistochemistry for vWF...
November 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27501128/neonatal-hepatitis-b-vaccination-impaired-the-behavior-and-neurogenesis-of-mice-transiently-in-early-adulthood
#15
Junhua Yang, Fangfang Qi, Yang Yang, Qunfang Yuan, Juntao Zou, Kaihua Guo, Zhibin Yao
The immune system plays a vital role in brain development. The hepatitis B vaccine (HBV) is administered to more than 70% of neonates worldwide. Whether this neonatal vaccination affects brain development is unknown. Newborn C57BL/6 mice were injected intraperitoneally with HBV or phosphate-buffered saline. HBV induced impaired behavioral performances and hippocampal long-term potentiation at 8 weeks (w) of age without influence at 4 or 12w. At 6w, there was decreased neurogenesis, M1 microglial activation and a neurotoxic profile of neuroimmune molecule expression [increased tumor necrosis factor-α and reduced interferon (IFN)-γ, brain-derived neurotrophic factor and insulin-like growth factor-1] in the hippocampus of the HBV-vaccinated mice...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27476150/surgical-intervention-and-perioperative-risk-factors-of-retroperitoneal-teratomas-in-children-a-single-institution-experience
#16
Shigehisa Fumino, Junnosuke Maniwa, Yuki Takeuchi, Kohei Sakai, Mayumi Higashi, Shigeyoshi Aoi, Taizo Furukawa, Osamu Kimura, Tatsuro Tajiri
PURPOSE: Retroperitoneal teratomas (RTs) are rare among germ cell tumors and predominantly occur in infants. RTs are often difficult to manage by perioperative management. In this study, we retrospectively reviewed our series of RTs. METHODS: Seventy patients with germ cell tumors were treated from 1989 to 2015 in our institution. Fourteen patients had RTs (3 boys and 11 girls). The median age at diagnosis was 5.5 months (range 0-64), and three were antenatally diagnosed...
September 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27438045/impact-of-dietary-tomato-juice-on-changes-in-pulmonary-oxidative-stress-inflammation-and-structure-induced-by-neonatal-hyperoxia-in-mice-mus-musculus
#17
Sheena Bouch, Richard Harding, Megan O'Reilly, Lisa G Wood, Foula Sozo
Many preterm infants require hyperoxic gas for survival, although it can contribute to lung injury. Experimentally, neonatal hyperoxia leads to persistent alterations in lung structure and increases leukocytes in bronchoalveolar lavage fluid (BALF). These effects of hyperoxia on the lungs are considered to be caused, at least in part, by increased oxidative stress. Our objective was to determine if dietary supplementation with a known source of antioxidants (tomato juice, TJ) could protect the developing lung from injury caused by breathing hyperoxic gas...
2016: PloS One
https://www.readbyqxmd.com/read/27422671/demonstration-of-functional-similarity-of-proposed-biosimilar-abp%C3%A2-501-to-adalimumab
#18
Jyoti Velayudhan, Yuh-Feng Chen, Amanda Rohrbach, Christina Pastula, Gwen Maher, Heather Thomas, Ryan Brown, Teresa L Born
BACKGROUND: Due to the complex molecular structure and proprietary manufacturing processes of monoclonal antibodies (mAbs), differences in structure and function may be expected during development of biosimilar mAbs. Important regulatory requirements for approval of biosimilar products involve comprehensive assessments of any potential differences between proposed biosimilars and reference mAbs, including differences in all known mechanisms of action, using sensitive and relevant methods...
August 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27422454/islet-derived-damage-associated-molecular-pattern-molecule-contributes-to-immune-responses-following-microencapsulated-neonatal-porcine-islet-xenotransplantation-in%C3%A2-mice
#19
Takeshi Itoh, Yuko Hata, Hitomi Nishinakamura, Kenjiro Kumano, Hiroyuki Takahashi, Shohta Kodama
BACKGROUND: Clinical allogeneic islet transplantation has become an attractive procedure for type 1 diabetes mellitus treatment. However, there is a severe shortage of human donors. Microencapsulated neonatal porcine islet (NPI) xenotransplantation may be an alternative transplantation procedure. Currently, the efficacy of microencapsulated NPI xenotransplantation into the peritoneal cavity is limited because of early non-function resulting from inflammation, which is a serious hindrance to promoting this procedure as a standard therapy...
September 2016: Xenotransplantation
https://www.readbyqxmd.com/read/27408996/effect-of-human-breast-milk-on-the-expression-of-proinflammatory-cytokines-in-caco-2-cells-after-hypoxia-re-oxygenation
#20
Wei-Yong Ruan, Ming-Yuan Bi, Wei-Wei Feng, Yu-Jun Wang, Wei-Quan Bu, Ling Lu
BACKGROUND: Neonatal necrotizing enterocolitis is a common and often fatal gastrointestinal disease, especially in premature infants. To study potential mechanisms underlying the protective effect of breast milk on neonatal necrotizing enterocolitis, we induced intestinal inflammation in a Caco-2 cell model of neonatal necrotizing enterocolitis by hypoxia/re-oxygenation to investigate whether breast milk supernatant fluid inhibited the expression of proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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