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Tumor necrosis factor and neonates

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https://www.readbyqxmd.com/read/29338067/the-influence-of-delayed-cord-clamping-and-cord-milking-on-inflammatory-cytokines-in-umbilical-vein-and-neonatal-circulation
#1
George Daskalakis, Angeliki Papapanagiotou, Charalambos Siristatidis, Petros Drakakis, Ioanna Mole, Anastasia Barbouni, Athanasios G Papavassiliou, Vasilios Pergialiotis
The purpose of the present study was to compare the levels of tumor necrosis factor a (TNF-a), and interleukins (IL) 1, 6, 8 and 10 in the umbilical cord and neonatal circulation among neonates with early and late cord clamping MATERIAL AND METHODS: A consecutive series of 76 cases that had an uncomplicated pregnancy and an uneventful parturition was evaluated. In 40 cases delayed cord clamping was used and in the remaining 36 cases early cord clamping was practiced. Blood samples were collected from the umbilical vein immediately after cord clamping and at 24 hours from the median cubital or basilic vein of the neonate RESULTS: Significant differences were noted in the hematocrit and hemoglobin levels at 24 hours that favored delayed clamping...
January 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29336466/magnolol-protects-against-ischemic-reperfusion-brain-damage-following-oxygen-glucose-deprivation-and-transient-focal-cerebral-ischemia
#2
Sheng-Yang Huang, Shih-Huang Tai, Che-Chao Chang, Yi-Fang Tu, Chih-Han Chang, E-Jian Lee
In the present study, the neuroprotective potential of magnolol against ischemia-reperfusion brain injury was examined via in vivo and in vitro experiments. Magnolol exhibited strong radical scavenging and antioxidant activity, and significantly inhibited the production of interleukin‑6, tumor necrosis factor‑a and nitrite/nitrate (NOX) in lipopolysaccharide-stimulated BV2 and RAW 264.7 cells when applied at concentrations of 10 and 50 µM, respectively. Magnolol (100 µM) also significantly attenuated oxygen‑glucose deprivation‑induced damage in neonatal rat hippocampal slice cultures, when administered up to 4 h following the insult...
January 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29295636/caffeine-prevents-bilirubin-induced-cytotoxicity-in-cultured-newborn-rat-astrocytes
#3
Mehmet Deliktaş, Hacer Ergin, Aydın Demiray, Hakan Akça, Özmert M A Özdemir, Mehmet Bülent Özdemir
OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain. Caffeine used in the treatment of apnea of prematurity was reported to decrease mechanical ventilation requirement, the frequencies of bronchopulmonary dysplasia, patent ductus arteriosus, cerebral palsy and neurodevelopmental disorders in very low birth weight infants. However, the effect of caffeine on hyperbilirubinemia was not yet clarified...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29274628/hydrogen-sulfide-protects-neonatal-rat-medulla-oblongata-against-prenatal-cigarette-smoke-exposure-via-anti-oxidative-and-anti-inflammatory-effects
#4
Xiang Yan, Fang Lei, Yajie Hu, Lihong Nie, Qingyi Jia, Hua Zhou, Fusheng Zhao, Yu Zheng
We previously demonstrated that hydrogen sulfide (H2S) protected neonatal rat medulla oblongata from prenatal cigarette smoke exposure (CSE) via anti-apoptotic effect. The present work further investigated the involvement of anti-oxidative and anti-inflammatory effects of H2S in the protection. Pregnant Sprague-Dawley rats were randomly divided into NaCl, CSE, CSE + NaHS (a donor of H2S) and NaHS groups. All the tests were performed with corresponding neonatal rats. Nissl staining revealed that NaHS treatment ameliorated neuronal chromatolysis in the hypoglossal nucleus and nucleus ambiguus resulted from prenatal CSE...
December 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29259700/neuroprotective-effects-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-periventricular-leukomalacia-like-brain-injury-in-neonatal-rats
#5
Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio, Ikuo Morita
Background: Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we examined whether mesenchymal stem cells (MSCs) possess neuroprotective property in a lipopolysaccharide (LPS)-induced neonatal rat PVL-like brain injury. Methods: Human umbilical cord-derived MSCs (UCMSCs) were used in this study. Four-day-old rats were intraperitoneally injected with LPS (15 mg/kg) to cause the PVL-like brain injury and were treated immediately after the LPS-injection with UCMSCs, conditioned medium prepared from MSCs (UCMSC-CM) or interferon-gamma (IFN-γ)-pretreated MSC (IFN-γ-UCMSC-CM)...
2017: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29234642/ureaplasma-species-differentially-modulate-pro-and-anti-inflammatory-cytokine-responses-in-newborn-and-adult-human-monocytes-pushing-the-state-toward-pro-inflammation
#6
Kirsten Glaser, Christine Silwedel, Markus Fehrholz, Ana M Waaga-Gasser, Birgit Henrich, Heike Claus, Christian P Speer
Background:Ureaplasma species have been associated with chorioamnionitis and preterm birth and have been implicated in the pathogenesis of neonatal short and long-term morbidity. However, being mostly commensal bacteria, controversy remains on the pro-inflammatory capacity of Ureaplasma. Discussions are ongoing on the incidence and impact of prenatal, perinatal, and postnatal infection. The present study addressed the impact of Ureaplasma isolates on monocyte-driven inflammation. Methods: Cord blood monocytes of term neonates and adult monocytes, either native or LPS-primed, were cultured with Ureaplasma urealyticum (U...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29233026/evaluation-of-4-methyl-2-2-methylbenzyl-amino-1-3-thiazole-5-carboxylic-acid-against-hyperglycemia-insulin-sensitivity-and-oxidative-stress-induced-inflammatory-responses-and-%C3%AE-cell-damage-in-the-pancreas-of-streptozotocin-induced-diabetic-rats
#7
Y N Paudel, M R Ali, S Bawa, S Shah, M Adil, A Siddiqui, A S Basheer, M Q Hassan, M Sharma
4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitivity, oxidative stress, and inflammatory mediators were evaluated in streptozotocin (STZ)-induced neonatal models of non-insulin-dependent diabetes mellitus (NIDDM) rats where NIDDM was induced in neonatal pups with single intraperitoneal injection of STZ (100 mg/kg). The effect of BAC (10 and 20 mg/kg, p...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29229141/neurodevelopment-impact-of-co2-pneumoperitoneum-in-neonates-experimental-study-in-a-rat-model
#8
Alice Miranda, Susana Roque, José M Pêgo, Jorge Correia-Pinto
BACKGROUND: Laparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes. MATERIALS AND METHODS: Rats were subjected to a systematic assessment of neurodevelopmental milestones between postnatal day 1 (PND 1) and PND 21...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29225576/vitamin-d-enhances-efficacy-of-oral-nifedipine-in-treating-preeclampsia-with-severe-features-a-double-blinded-placebo-controlled-and-randomized-clinical-trial
#9
Dan-Dan Shi, Yong Wang, Jun-Jun Guo, Ling Zhou, Na Wang
Vitamin D (VD) has exhibited immunomodulatory role in the pathogenesis of preeclampsia. We hypothesize VD potentiate nifedipine treatment for preeclampsia by shortened the time to control blood pressure and prolong time before subsequent hypertensive crisis. We conduct a randomized trial of 683 primigravid women with preeclampsia, who were assigned to different treatment groups, either nifedipine+placebo or nifedipine+VD orally, by random after screening. Primary endpoints include time to control hypertension and time before another hypertensive crisis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29138831/anti%C3%A2-inflammatory-effect-of-migri%C3%A2-heal%C3%A2-in-an-in%C3%A2-vitro-inflammatory-model-of-primary-mixed-glial-cells
#10
Mahmoud Hassani, Farzaneh Sabouni, Mohammad Ansari, Solaleh Emamgholipour, Mohammad-Sadegh Fallah, Shah-Sanam Abbasi, Saeed Ansari Majd
Migri‑Heal®, is a novel herbal remedy that was introduced for the treatment of migraine headaches. Previous studies revealed that this drug may reduce nitric oxide (NO) in an in vitro inflammatory model. The aim of the present study was to investigate the anti‑inflammatory effect of Migri‑Heal® on primary mix glial cells stimulated with LPS. In the current study, neonatal rat primary mix glial cells were isolated from the mixed glial cultures via shaking, and cultured in Dulbecco's' modified Eagle's medium supplemented with 10% fetal bovine serum...
January 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136347/pro-inflammatory-mediator-responses-from-neonatal-airway-epithelial-cells-and-early-childhood-wheeze
#11
Steve Turner, David Miller, Garry M Walsh, Alison Scaife, Ultan F Power, Michael D Shields, Graham Devereux
BACKGROUND: Airway epithelial cell (AEC) function differs between children with and without asthma. Here, we associated neonatal AEC function with asthma symptoms at 4 years of age. METHODS: Nasal AEC were collected from neonates within 48 h of birth. Cells were cultured and stimulated with tumor necrosis factor alpha/interleukin-1 beta (TNFα/IL-1β), lipopolysaccharide (LPS), or house dust mite (HDM). Absolute concentrations of pro-inflammatory mediators in the culture supernatant were quantified and expressed as median [interquartile range] in pg/mg protein...
November 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29121823/effect-of-tumor-necrosis-factor-alpha-dose-and-exposure-time-on-tumor-necrosis-factor-induced-gene-6-activation-by-neonatal-and-adult-mesenchymal-stromal-cells
#12
Shiva Hamidian Jahromi, Yunqing Li, John E Davies
Tumor necrosis factor (TNF)-stimulated gene 6 (TSG-6) is a major anti-inflammatory mediator released by activated mesenchymal stromal cells (MSCs). Neonatal MSCs are considered more metabolically active than cells derived from adult tissues, and potentially less heterogeneous. We hypothesized that a TNF-α activated neonatal MSC population (human umbilical cord perivascular cells-HUCPVCs) would show an enhanced level of TSG-6 activation compared to adult bone marrow MSCs (BMMSCs). Thus, we stimulated HUCPVCs, and both human and mouse BMMSCs with 1, 10, 50, and 100ng/mL of recombinant TNF-α over various exposure times...
November 9, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29107071/role-of-tlr4-in-olfactory-based-spatial-learning-activity-of-neonatal-mice-after-developmental-exposure-to-diesel-exhaust-origin-secondary-organic-aerosol
#13
Nay Chi Nway, Yuji Fujitani, Seishiro Hirano, Ohn Mar, Tin-Tin Win-Shwe
Exposure to ambient air pollutants has been reported to have various adverse health impacts. Ambient particulate matter comprises primary particles released directly via engine exhaust and secondary organic aerosols (SOAs) formed from oxidative reactions of the ultrafine particle fraction of diesel exhaust (DE). Toll-like receptor 4 (TLR4) is well known to initiate the inflammatory cascade in the central nervous system. However, whether and how DE and DE-SOA exposure influences TLR4 signaling in the immature brain remains unclear...
October 26, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29105819/neuroprotective-effect-of-licochalcone-a-against-oxygen-glucose-deprivation-reperfusion-in-rat-primary-cortical-neurons-by-attenuating-oxidative-stress-injury-and-inflammatory-response-via-the-sirt1-nrf2-pathway
#14
Xiaohong Liu, Ying Ma, Xiaodi Wei, Ting Fan
Perinatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal death and neurological disability. Oxidative stress and neuroinflammation are typical pathogenic factors of HIE. Licochalcone A (LCA) exerts various biological properties, including anti-inflammatory and antioxidant activities. However, no data have been reported to elucidate the role of LCA in the development of HIE. In the present study, primary cultured rat cortical neurons were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro to simulate the in vivo situation of neonatal HIE...
November 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29084133/modulation-of-the-senescence-associated-inflammatory-phenotype-in-human-fibroblasts-by-olive-phenols
#15
Beatrice Menicacci, Caterina Cipriani, Francesca Margheri, Alessandra Mocali, Lisa Giovannelli
Senescent cells display an increase in the secretion of growth factors, inflammatory cytokines and proteolytic enzymes, termed the "senescence-associated-secretory-phenotype" (SASP), playing a major role in many age-related diseases. The phenolic compounds present in extra-virgin olive oil are inhibitors of oxidative damage and have been reported to play a protective role in inflammation-related diseases. Particularly, hydroxytyrosol and oleuropein are the most abundant and more extensively studied. Pre-senescent human lung (MRC5) and neonatal human dermal (NHDF) fibroblasts were used as cellular model to evaluate the effect of chronic (4-6 weeks) treatment with 1 μM hydroxytyrosol (HT) or 10 μM oleuropein aglycone (OLE) on senescence/inflammation markers...
October 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29077529/postnatal-melatonin-treatment-protects-against-affective-disorders-induced-by-early-life-immune-stimulation-by-reducing-the-microglia-cell-activation-and-oxidative-stress
#16
I Berkiks, H Benmhammed, A Mesfioui, A Ouichou, A El Hasnaoui, S Mouden, T Touil, Y Bahbiti, R Nakache, A El Hessni
BACKGROUND: Systemic inflammation induced by neonatal infection may result as long-term hyper-activation of microglial cells followed by an overproduction of pro-inflammatory cytokines, such as tumor necrosis factor-alpha, nitric oxide and lipid peroxidation. Those inflammation mediators can trigger behavioral disruption and/or cognitive disorders. OBJECTIVE: The present work aims to evaluate the effect of melatonin (a cytokine release modulator and antioxidant agent) in the reduction of the prefrontal microglia activation and depressive-like behaviors induced by lipopolysaccharide (LPS) injection in adult rats...
November 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29077174/clinical-significance-of-dynamic-measurements-of-seric-tnf-%C3%AE-hmgbl-and-nse-levels-and-aeeg-monitoring-in-neonatal-asphyxia
#17
X-H Zhang, B-L Zhang, S-M Guo, P Wang, J-W Yang
OBJECTIVE: This study investigates the clinical value of monitoring blood levels of tumor necrosis factor-α (TNF-α), high mobility group protein Bl (HMGBl), and neuron-specific enolase (NSE), and examining an amplitude-integrated electroencephalogram (aEEG) for the diagnosis and short-term prognosis of brain damage caused by neonatal asphyxia. PATIENTS AND METHODS: Sixty full-term neonates born in Yidu Central Hospital from January to December 2015 were enrolled in the study...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28950663/betulinic-acid-protects-the-neuronal-damage-in-new-born-rats-from-isoflurane-induced-apoptosis-in-the-developing-brain-by-blocking-fasl-fas-signaling-pathway
#18
Dongwei Wang, Ping Chen, Lei Chen, Fanrong Zeng, Rongjia Zang, Haiping Liu, Chunfeng Lu
Betulinic acid (BA) is a naturally occurring pentacyclic lupane group triterpenoid, has reported to protect cerebral ischemia. Present study evaluates the protective effect of betulinic acid on the isoflurane-induced neuronal damage in neonatal mice. All the mice of 7days age were exposed to isoflurane (2%; 2h) for the duration of 3day. At the end of protocol cognitive function was evaluated by Morris water maze (MWM) test. However count of apoptotic cells were estimated by TUNEL staining. Concentration of oxidative stress parameters [superoxide dismutase (SOD); catalase (CAT) and reduced glutathione (GSH)], cytokines [tumor necrosis factor (TNF-α); interlukin-6 (IL-6) and IL-1β] and expressions of caspase 3, FAS and FASL were estimated in the neuronal cells...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28942514/intrauterine-hyperglycemia-induced-inflammatory-signalling-via-the-receptor-for-advanced-glycation-end-products-in-the-cardiac-muscle-of-the-infants-of-diabetic-mother-rats
#19
Ritsuko Kawaharada, Haruna Masuda, Zhenyi Chen, Eric Blough, Tomoko Kohama, Akio Nakamura
PURPOSE: Gestational diabetes is associated with increased risk to the health of the mother and her offspring. In particular, the infants of diabetic mothers (IDMs) exhibit elevated levels of preterm birth, macrosomia, hypoglycemia, hypocalcemia, and cardiomyopathy. We have previously reported that IDMs showed abnormalities in cardiac Akt-related insulin signalling, and that these deficiencies in Akt-related signalling were attenuated by supplementing the maternal diet with fish-oil. Herein, we investigated whether the eicosapentaenoic acid (EPA) found in fish oil can be used to attenuate diabetes associated impairments in cardiomyocyte signalling...
September 23, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28926473/hydrogen-gas-attenuates-sevoflurane-neurotoxicity-through-inhibiting-nuclear-factor-%C3%AE%C2%BA-light-chain-enhancer-of-activated-b-cells-signaling-and-proinflammatory-cytokine-release-in-neonatal-rats
#20
Yiwei Shi, Gang Wang, Jinyuan Li, Wenli Yu
Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits in neonates. Molecular hydrogen is reported to be a potential neuroprotective agent because of its antioxidative and anti-inflammatory activities. This study aimed to investigate the effect of hydrogen gas on sevoflurane neurotoxicity. The newborn rats were treated with sevoflurane and/or hydrogen gas for 2 h...
December 6, 2017: Neuroreport
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