keyword
MENU ▼
Read by QxMD icon Read
search

Immunology neonates

keyword
https://www.readbyqxmd.com/read/29902818/-substances-in-the-bovine-colostrum-a-survey
#1
Sebastian Ganz, Michael Bülte, Zdzislaw Gajewski, Axel Wehrend
The best studied substances in bovine colostrum are the immunoglobulins. They are absorbed in the small intestine of the neonate by pinocytosis. The Fc-receptor is not highly involved in this process in calves compared to other species. However, this receptor plays a crucial role in the transport of immunoglobulins from the circulation of the dam to the udder and, therefore, into the colostrum. During colostrogenesis, which starts up to 8 weeks prior to parturition, up to 500 g of immunoglobulins are transferred daily by this process...
June 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29895363/low-dose-thimerosal-ethyl-mercury-is-still-used-in-infants-vaccines-should-we-be-concerned-with-this-form-of-exposure
#2
REVIEW
José G Dórea
In developing countries, Thimerosal-containing vaccines (TCV) are the main causes of organic Hg exposure for newborns, neonates, and infants immunized with TCV. This article addresses early-life exposure to this unique organic mercury compound (ethylmercury-EtHg) and the risks of its exposure. English language studies pertaining to Thimerosal/EtHg toxicity and exposure during early life were searched in PubMed; and, those publications judged to be relevant to the topic of this review were selected. The risk from the neurotoxic effects of pre- and post-natal Hg exposures depend, in part, on aggravating or attenuating environmental and/or genetic-associated factors...
September 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29892152/neonatal-presentation-of-unremitting-inflammatory-bowel-disease
#3
Sara Ebrahimi, Gholamreza Khademi, Seyed Ali Jafari, Nona Zaboli Nejad, Abdolreza Norouzy, Bahareh Imani
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian female neonate presented with severe bloody diarrhea, poor feeding, abdominal distention, and dehydration suggesting severe proctocolitis due to an allergy to the protein in cow's milk...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29804197/co-appearance-of-opv-and-bcg-vaccine-derived-complications-in-two-infants-with-severe-combined-immunodeficiency
#4
Sophia Heiman, Merav Weil, Lester M Shulman, Amos J Simon, Atar Lev, Raz Somech, Tali Stauber
Infants with severe combined immunodeficiency (SCID) are at risk of developing severe life-threatening infections if they are inadvertently given attenuated live vaccines. Concomitant appearance of two live vaccine-associated complications in one person is rarely reported. In this study, we present two SCID infants, who received BCG and oral polio vaccines according to their local immunization schedule early in life, before the diagnosis of immunodeficiency was made. Their clinical presentation, extensive immunological workup, genetic tests, and clinical disease course are presented...
May 26, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29797049/successful-overexpression-of-wild-type-inhibitor-2-of-pp1-in-cardiovascular-cells
#5
Thorsten Krause, Stefanie Grote-Wessels, Felix Balzer, Peter Boknik, Ulrich Gergs, Uwe Kirchhefer, Igor B Buchwalow, Frank U Müller, Wilhelm Schmitz, Joachim Neumann
About half of the cardiac serine/threonine phosphatase activity is due to the activity of protein phosphatase type 1 (PP1). The activity of PP1 can be inhibited by an endogenous protein for which the expression inhibitor-2 (I-2) has been coined. We have previously described a transgenic mouse overexpressing a truncated form of I-2. Here, we have described and initially characterized several founders that overexpress the non-truncated (i.e., full length) I-2 in the mouse heart (TG) and compared them with non-transgenic littermates (WT)...
May 24, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29791872/gene-expression-in-cord-blood-links-genetic-risk-for-neurodevelopmental-disorders-with-maternal-psychological-distress-and-adverse-childhood-outcomes
#6
Michael S Breen, Aliza P Wingo, Nastassja Koen, Kirsten A Donald, Mark Nicol, Heather J Zar, Kerry J Ressler, Joseph D Buxbaum, Dan J Stein
Prenatal exposure to maternal stress and depression has been identified as a risk factor for adverse behavioral and neurodevelopmental outcomes in early childhood. However, the molecular mechanisms through which maternal psychopathology shapes offspring development remain poorly understood. We applied transcriptome-wide screens to 149 umbilical cord blood samples from neonates born to mothers with posttraumatic stress disorder (PTSD; n=20), depression (n=31) and PTSD with comorbid depression (n=13), compared to carefully matched trauma exposed controls (n=23) and healthy mothers (n=62)...
May 20, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29761581/congenital-zika-syndrome-pitfalls-in-the-placental-barrier
#7
REVIEW
Nia Robinson, Evangelina E Mayorquin Galvan, Isidro G Zavala Trujillo, Maria G Zavala-Cerna
Much progress with respect to congenital Zika virus (ZIKV) pathogenesis has been achieved after the 2015 outbreak in Brazil. It is now accepted that ZIKV is vertically transmitted, infects cells of the developing central nervous system and the placenta, yet it is unclear to what extent placental affection contributes to the development of congenital ZIKV. The association between fulminant villitis and severe fetal involvement emerges as a possibility. ZIKV is unique among the Flaviviruses in its ability to be sexually transmitted, possibly responsible for its teratogenicity...
May 15, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29750838/gender-disparities-in-preterm-neonatal-outcomes
#8
REVIEW
David N O'Driscoll, Matthew McGovern, Catherine M Greene, Eleanor J Molloy
AIM: From birth to old age, males generally have poorer disease outcomes compared to females. Preterm infants display a marked gender disparity in disease outcomes and the underlying mechanisms are not well delineated. Our aim was to review the literature on clinical outcomes between preterm infants of different genders and discuss the potential mechanisms underlying the differences observed. METHODS: A literature review was undertaken for experimental and clinical research related to gender differences in preterm outcomes...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29750386/saliva-in-the-omics-era-a-promising-tool-in-paediatrics
#9
Eftychia Pappa, Eleni Kousvelari, Heleni Vastardis
In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its non-invasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29732576/transfusions-of-least-incompatible-blood-with-intravenous-immunoglobulin-plus-steroids-cover-in-two-patients-with-rare-antibody
#10
Nay Win, Malcolm Needs, Nicole Thornton, Robert Webster, Cherry Chang
BACKGROUND: The therapeutic value of the use of intravenous immunoglobulin (IVIG) to correct anemia and thrombocytopenia as a result of immunologic causes (hemolytic disease of the fetus and newborn and fetal or neonatal alloimmune thrombocytopenia) have been well established. Few published papers exist regarding the use of IVIG in adult settings. We report two patients with clinically significant antibodies against high-incidence antigens, who were successfully transfused with incompatible red blood cells (RBCs), in conjunction with IVIG plus steroids and IVIG...
May 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29713554/postinfantile-giant-cell-hepatitis-with-features-of-acute-severe-autoimmune-hepatitis-probably-triggered-by-diclofenac-in-a-patient-with-primary-myelofibrosis
#11
Pinelopi Arvaniti, Kalliopi Zachou, George K Koukoulis, George N Dalekos
Giant cell hepatitis (GCH) is commonly reported in neonatal and infantile liver diseases but rarely in adults where the term postinfantile GCH (PIGCH) is used. PIGCH is associated with many diseases, including drugs toxicity, viruses, and autoimmune liver diseases, with autoimmune hepatitis (AIH) being the most prevalent. We present a case of PIGCH in a 76-year-old female without known history of liver disease who suffered from an acute severe episode of hepatitis. After careful exclusion of other hepatitis causes by imaging, virological, immunological, and microbiological investigations, a diagnosis of acute severe AIH (AS-AIH) was established...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29694997/role-of-lactoferrin-in-neonates-and-infants-an-update
#12
Paolo Manzoni, Alberto Dall'Agnola, Daniel Tomé, David A Kaufman, Elena Tavella, Marta Pieretto, Alessandro Messina, Daniele De Luca, Marc Bellaiche, Alexis Mosca, Hugues Piloquet, Umberto Simeoni, Jean-Charles Picaud, Antonio Del Vecchio
Lactoferrin is one of the most represented and important bioactive proteins in human and mammal milk. In humans, lactoferrin is responsible for several actions targeting anti-infective, immunological, and gastrointestinal domains in neonates, infants, and young children. Evidence-based data vouch for the ability of supplemented lactoferrin to prevent sepsis and necrotizing enterocolitis in preterm infants and to reduce the burden of morbidity related to gastrointestinal and respiratory pathogens in young children...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29671238/dairy-calf-rearing-unit-and-infectious-diseases-diarrhea-outbreak-by-bovine-coronavirus-as-a-model-for-the-dispersion-of-pathogenic-microorganisms
#13
Amauri Alcindo Alfieri, Juliane Ribeiro, Luciana de Carvalho Balbo, Elis Lorenzetti, Alice Fernandes Alfieri
Dairy calf rearing unit is a management system that is only recently being implemented by some milk producer's cooperatives in southern Brazil. However, aspects related to the health profile of the heifer calves that arrive in the rearing unit as well as about biosecurity practices and microbiological challenges have not yet been evaluated in this rearing system in a tropical country. Diarrhea is the main and most frequent consequence of enteric infections in newborn calves. This study, through some etiological and epidemiological characteristics of an outbreak of neonatal diarrhea, has the aim to alert to the possibility of pathogenic microorganism spread in a dairy heifer calf rearing unit...
April 18, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29664572/ilc2-memory-recollection-of-previous-activation
#14
REVIEW
Itziar Martinez-Gonzalez, Maryam Ghaedi, Catherine A Steer, Laura Mathä, Eric Vivier, Fumio Takei
Immunological memory, traditionally thought to belong to T and B cells, has now been extended to innate lymphocytes, including NK cells and ILC2s, myeloid cells such as macrophages, also termed "trained immunity" and more recently to epithelial stem cells. In this review, we discuss the mechanisms underlying memory generation on ILC2s and speculate about their potential role in human allergic diseases, such as asthma. Moreover, we examine the relevance of the spontaneous ILC2 activation in the lung during the neonatal period in order to efficiently respond to stimuli later in life...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29630015/maternal-pyrexia-and-villitis-of-unknown-etiology
#15
Dorothy F Graham, Eileen Sung, Bligh Berry
BACKGROUND: Villitis of unknown etiology is an inflammatory placental condition associated with adverse pregnancy outcomes, including fetal growth restriction and preterm birth. CASE: We describe maternal pyrexia with daily rigors in the third trimester of two consecutive pregnancies in the same woman. In her second pregnancy, we found no evidence of infection despite an extensive antenatal investigation (blood and urine cultures, serologies, chest X-ray, abdominal ultrasonogram, echocardiogram)...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29625076/lymphatic-cannulation-models-in-sheep-recent-advances-for-immunological-and-biomedical-research
#16
REVIEW
Elizabeth A Washington, Stuart R Barber, Christina M Murray, Helen M S Davies, Wayne G Kimpton, Hung-Hsun Yen
Lymphatic cannulation models are useful tools for studying the immunobiology of the lymphatic system and the immunopathology of specific tissues in diseases. Sheep cannulations have been used extensively, as models for human physiology, fetal and neonatal development, human diseases, and for studies of ruminant pathobiology. The development of new and improved cannulation techniques in recent years has meant that difficult to access sites, such as mucosal associated tissues, are now more readily available to researchers...
June 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29614774/the-brain-intestinal-mucosa-appendix-microbiome-brain-loop
#17
Luis Vitetta, Gemma Vitetta, Sean Hall
The brain and the gut are connected from early fetal life. The mother's exposure to microbial molecules is thought to exert in utero developmental effects on the fetus. These effects could importantly underpin the groundwork for subsequent pathophysiological mechanisms for achieving immunological tolerance and metabolic equilibrium post birth, events that continue through to 3-4 years of age. Furthermore, it is understood that the microbiome promotes cues that instruct the neonate's mucosal tissues and skin in the language of molecular and cellular biology...
April 1, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29610184/a-novel-presentation-of-littoral-cell-angioma-and-lymphatic-malformations-in-a-neonate
#18
Lindsey Gakenheimer-Smith, Jeffrey Mohlman, Kate VandenHeuvel, William Daniel Jackson, William Thomsen, Adam Stevenson, Frank Cipriano
This case report describes a novel presentation of littoral cell angioma (LCA) and lymphatic malformations involving the omentum and mesentery. To our knowledge, these 2 entities have not been reported in the same patient. A 1-month term infant male presented with chylous ascites. During his workup, imaging detected splenic nodules. Biopsies revealed that the nodules were LCA and the chylous ascites was secondary to microscopic mesenteric and omental lymphatic malformations. Evaluation for a secondary malignancy, an underlying immunologic defect, and genetic causes were unrevealing...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29596733/skin-barrier-in-the-neonate
#19
Alain Taïeb
The purpose of this review is to focus on determinants of skin barrier function in neonates at molecular and cellular levels. The skin barrier is critical in terms of water and gas exchanges during fetal life and undergoes rapid changes at birth, followed by a progressive maturation. Consequences of skin barrier disruption can be extremely detrimental or lethal, as shown in severe genetic epidermal defects. In this context, the fine-tuned rapid adaptation from a liquid to a gaseous milieu is not fully understood...
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29595094/paediatric-hiv-1-infection-updated-strategies-of-prevention-mother-to-child-transmission
#20
Alessandra Lumaca, Luisa Galli, Maurizio de Martino, Elena Chiappini
INTRODUCTION: HIV-1 epidemiology is changing and prevention of mother-to-child transmission (PMTCT) strategies have been continuously optimized over time. However, the correct management of infected women during pregnancy is crucial for PMTCT and cases of vertical transmission continue to occur. OBJECTIVE: To review the most recent evidence regarding the prevention of MTCT in resource-rich and resource-limited settings, focalizing on new possible approaches. RESULTS: New issues regard the optimal antiretroviral therapy regimen for pregnant women with good immunological control, the use of intrapartum zidovudine (ZDV) in pregnant women with low viral load, the optimization of prophylaxis in the settings where breastfeeding is recommended and use of combined neonatal prophylaxis (CNP) in infants at high-risk for MTCT...
March 29, 2018: Journal of Chemotherapy
keyword
keyword
110358
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"