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electrospun nanofibrous scaffold

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https://www.readbyqxmd.com/read/28277009/nanofibrous-scaffold-from-electrospinning-biodegradable-waterborne-polyurethane-poly-vinyl-alcohol-for-tissue-engineering-application
#1
Yingke Wu, Weiwei Lin, Hongye Hao, Jiehua Li, Feng Luo, Hong Tan
A series of nanofibrous scaffolds, free of organic solvents, are prepared by electrospinning biodegradable waterborne polyurethane (BWPU) emulsion blending with aqueous poly(vinyl alcohol)(PVA). Tuning the proration of BWPU to PVA, various nanofibers with diameter from 370 to 964 nm are obtained. Strong intermolecular interaction existing between them benefits to the electrospun of BWPU emulsion, which is demonstrated by dynamic thermomechanical analysis and Fourier transform infrared spectroscopy. The nontoxic nanofibrous scaffolds with porous structure, which is similar to the natural extracellular matrix, favor to the attachment and proliferation of the L929 fibroblasts...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28271816/an-overview-on-application-of-natural-substances-incorporated-with-electrospun-nanofibrous-scaffolds-to-development-of-innovative-wound-dressings
#2
Nosratollah Zarghami, Roghayeh Sheervalilou, Amir Fattahi, Abbas Mohajeri, Mehdi Dadashpour, Younes Pilehvar-Soltanahmadi
Conventional dressings are cost-effective and highly absorbent, but not effectual enough to promote hemostasis, adherence and in holding a moist wound bed. Thanks to the developments in the field of nanotechnology and bioengineering, one of the promising current trends is to move progress of innovative wound dressings, merging the application of traditional healing agents and modern products/practices, such as hydrocolloids, hydrogels, films and nanofibers. The electrospun nanofibers webs can provide the essential parameters require for wound dressing to heal wounds including absorptivity, oxygen permeability, and non-adherence to the healing tissue, barrier to bacteria, bioactivity and occlusivity...
March 8, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28269204/electrospinning-of-gelatin-and-smpu-with-carbon-nanotubes-for-tissue-engineering-scaffolds
#3
Monica A Mejia, Lina M Hoyos, Jenniffer Zapata, Luz M Restrepo, Maria E Moneada
The nanofibres created by electrospinning technique are currently used for a variety of applications in tissue engineering; and Gelatin and Polyurethane Shape-Memory (SMPU) have important results in biomedicine. Similarly, carbon nanotubes combined with other biomaterials change important properties, opening new opportunities for biomedical applications. In this work, we constructed scaffold using electrospinning technique based in bovine-hide gelatin, SMPU and both materials hybrid with carbon nanotube. Morphology and cytotoxicity were evaluated and mechanical properties for two materials were obtained in scaffold building...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28256792/the-effect-of-increasing-the-pore-size-of-nanofibrous-scaffolds-on-the-osteogenic-cell-culture-using-a-combination-of-sacrificial-agent-electrospinning-and-ultrasonication
#4
Mahdiyeh Aghajanpoor, Sameereh Hashemi-Najafabadi, Mohamadreza Baghaban-Eslaminejad, Fatemeh Bagheri, Seyyed Mohammad Mousavi, Foruogh Azam Sayyahpour
One of the major problems associated with the electrospun scaffolds is their small pore size, which limits the cellular infiltration for bone tissue engineering. In this study, the effect of increasing the pore size on cellular infiltration was studied in poly‌caprolactone (PCL)/nanohydroxyapatite (nHA) electrospun scaffolds, which were modified using ultrasonication, co-electrospinning with poly (ethylene oxide) (PEO), and a combination of both. Ultrasonic process was optimized by central composite design (CCD)...
March 3, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28227434/electrospinning-of-gelatin-and-smpu-with-carbon-nanotubes-for-tissue-engineering-scaffolds
#5
Monica A Mejia, Lina M Hoyos, Jenniffer Zapata, Luz M Restrepo, Maria E Moneada, Monica A Mejia, Lina M Hoyos, Jenniffer Zapata, Luz M Restrepo, Maria E Moneada, Lina M Hoyos, Jenniffer Zapata, Monica A Mejia, Luz M Restrepo
The nanofibres created by electrospinning technique are currently used for a variety of applications in tissue engineering; and Gelatin and Polyurethane Shape-Memory (SMPU) have important results in biomedicine. Similarly, carbon nanotubes combined with other biomaterials change important properties, opening new opportunities for biomedical applications. In this work, we constructed scaffold using electrospinning technique based in bovine-hide gelatin, SMPU and both materials hybrid with carbon nanotube. Morphology and cytotoxicity were evaluated and mechanical properties for two materials were obtained in scaffold building...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221758/synthesis-and-fabrication-of-collagen-coated-ostholamide-electrospun-nanofiber-scaffold-for-wound-healing
#6
Subramani Kandhasamy, Sathiamurthi Perumal, Balaraman Madhan, Narayanan Umamaheswari, Javid Ahmad Banday, Paramasivan Thirumalai Perumal, Vichangal Pridiuldi Santhanakrishnan
A novel scaffold for effective wound healing treatment was developed utilizing natural product bearing collagen-based biocompatible electrospun nanofibers. Initially, ostholamide (OSA) was synthesized from osthole (a natural coumarin), characterized by (1)H, (13)C, DEPT-135 NMR, ESI-MS, and FT-IR spectroscopy analysis. OSA was incorporated into polyhydroxybutyrate (PHB) and gelatin (GEL), which serve as templates for electrospun nanofibers. The coating of OSA-PHB-GEL nanofibers with collagen resulted in PHB-GEL-OSA-COL nanofibrous scaffold which mimics extracellular matrix and serves as an effective biomaterial for tissue engineering applications, especially for wound healing...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28155052/a-nanofibrous-electrospun-patch-to-maintain-human-mesenchymal-cell-stemness
#7
L Pandolfi, N Toledano Furman, Xin Wang, C Lupo, J O Martinez, M Mohamed, F Taraballi, E Tasciotti
Mesenchymal stem cells (MSCs) have been extensively investigated in regenerative medicine because of their crucial role in tissue healing. For these properties, they are widely tested in clinical trials, usually injected in cell suspension or in combination with tridimensional scaffolds. However, scaffolds can largely affect the fates of MSCs, inducing a progressive loss of functionality overtime. The ideal scaffold must delay MSCs differentiation until paracrine signals from the host induce their change. Herein, we proposed a nanostructured electrospun gelatin patch as an appropriate environment where human MSCs (hMSCs) can adhere, proliferate, and maintain their stemness...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28140360/assembling-of-electrospun-meshes-into-three-dimensional-porous-scaffolds-for-bone-repair
#8
Juqing Song, Guanglin Zhu, Lin Wang, Geng An, Xuetao Shi, Yingjun Wang
Technical limitations of traditional electrospinning make it hard to produce three-dimensional (3D) scaffolds with hierarchical pore structures. Here, porous polycaprolactone (PCL) nanofiber meshes with different nano-hydroxyapatite (nHA) concentrations were prepared by electrospinning with stainless steel mesh as the collector, and 3D porous nanofiber scaffolds were fabricated via layer-by-layer assembly with a special binder (18% PCL/DCM solution). The single layer nanofiber mesh possessed very regular morphology with a hollow structure, and the nHA was not only embedded in the nanofiber but also exposed on the surfaces of the fiber, resulting in the improved surface chemical properties...
February 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/28125204/fenugreek-incorporated-silk-fibroin-nanofibers-a-potential-antioxidant-scaffold-for-enhanced-wound-healing
#9
Sowmya Selvaraj, Nishter Nishad Fathima
Free radicals are generated by various biochemical pathways in the living system, causing severe oxidative damage to the biomolecules leading to adverse disease conditions. Hence, there is an increasing interest in antioxidant studies for preventing the effects of these free radicals. Herein, we propose a novel electrospun scaffold with antioxidant properties that can be used as wound healing material. Fenugreek, a natural antioxidant incorporated silk fibroin nanofiber, was prepared in four different ratios by the co-electrospinning method...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28117963/chitosan-intercalated-montmorillonite-poly-vinyl-alcohol-nanofibers-as-a-platform-to-guide-neuron-like-differentiation-of-human-dental-pulp-stem-cells
#10
Hatef Ghasemi Hamidabadi, Zahra Rezvani, Maryam Nazm Bojnordi, Haji Shirinzadeh, Alexander M Seifalian, Mohammad Taghi Joghataei, Mojgan Razaghpour, Abbas Alibakhshi, Abolfazl Yazdanpanah, Maryam Salimi, Masoud Mozafari, Aleksandra M Urbanska, Rui L Reis, Subhas C Kundu, Mazaher Gholipourmalekabadi
In this study, we present a novel chitosan-intercalated montmorillonite/Poly(Vinyl alcohol) (OMMT/PVA) nanofibrous mesh as a microenvironment for guiding differentiation of human dental pulp stem cells (hDPSCs) toward neuron-like cells. The OMMT was prepared through ion exchange reaction between the montmorillonite (MMT) and chitosan. The PVA solutions containing various concentrations of OMMT were electrospun to form 3-D OMMT-PVA nanofibrous meshes. The biomechanical and biological characteristics of the nanofibrous meshes were evaluated by ATR-FTIR, XRD, SEM, MTT, LDH specific activity, contact angle, and DAPI staining...
January 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28095765/electrospun-nanofibre-bundles-and-yarns-for-tissue-engineering-applications-a-review
#11
Richard A O'Connor, Garrett B McGuinness
Nanofibre membranes produced through the electrospinning process have been studied extensively over the past decade for a number of high demand applications including use as tissue engineered scaffolds. Despite possessing desirable properties including high surface area to volume ratios and enhanced mechanical properties, they ultimately suffer from a lack of cellular infiltration. Variations on the process include the production of highly aligned filaments of electrospun fibres referred to as bundles and yarns...
November 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28093364/fabrication-of-nanofibrous-electrospun-scaffolds-from-a-heterogeneous-library-of-co-and-self-assembling-peptides
#12
Mahboubeh Maleki, Antonino Natalello, Raffaele Pugliese, Fabrizio Gelain
Self-assembling (SAPs) and co-assembling peptides (CAPs) are driving increasing enthusiasm as synthetic but biologically inspired biomaterials amenable of easy functionalization for regenerative medicine. On the other hand, electrospinning (ES) is a versatile technique useful for tailoring the nanostructures of various biomaterials into scaffolds resembling the extracellular matrices found in organs and tissues. The synergistic merging of these two approaches is a long-awaited advance in nanomedicine that has not been deeply documented so far...
January 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087448/fabrication-and-characterization-of-electrospun-cellulose-nano-hydroxyapatite-nanofibers-for-bone-tissue-engineering
#13
Chenghong Ao, Yan Niu, Ximu Zhang, Xu He, Wei Zhang, Canhui Lu
Nanofibrous scaffolds from cotton cellulose and nano-hydroxyapatite (nano-HA) were electrospun for bone tissue engineering. The solution properties of cellulose/nano-HA spinning dopes and their associated electrospinnability were characterized. Morphological, thermal and mechanical properties of the electrospun cellulose/nano-HA nanocomposite nanofibers (ECHNN) were measured and the biocompatibility of ECHNN with human dental follicle cells (HDFCs) was evaluated. Scanning electron microscope (SEM) images indicated that the average diameter of ECHNN increased with a higher nano-HA loading and the fiber diameter distributions were well within the range of natural ECM (extra cellular matrix) fibers (50-500nm)...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28071988/braided-and-stacked-electrospun-nanofibrous-scaffolds-for-tendon-and-ligament-tissue-engineering
#14
Benjamin B Rothrauff, Brian B Lauro, Guang Yang, Richard E Debski, Volker Musahl, Rocky S Tuan
Tendon and ligament injuries are a persistent orthopedic challenge given their poor innate healing capacity. Nonwoven electrospun nanofibrous scaffolds composed of polyesters have been used to mimic the mechanics and topographical cues of native tendons and ligaments. However, nonwoven nanofibers have several limitations that prevent broader clinical application, including poor cell infiltration, as well as tensile and suture-retention strengths that are inferior to native tissues. In this study, multilayered scaffolds of aligned electrospun nanofibers of two designs-stacked or braided-were fabricated...
February 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28011142/cell-matrix-mechanical-interaction-in-electrospun-polymeric-scaffolds-for-tissue-engineering-implications-for-scaffold-design-and-performance
#15
REVIEW
Kelsey M Kennedy, Archana Bhaw-Luximon, Dhanjay Jhurry
Engineered scaffolds produced by electrospinning of biodegradable polymers offer a 3D, nanofibrous environment with controllable structural, chemical, and mechanical properties that mimic the extracellular matrix of native tissues and have shown promise for a number of tissue engineering applications. The microscale mechanical interactions between cells and electrospun matrices drive cell behaviors including migration and differentiation that are critical to promote tissue regeneration. Recent developments in understanding these mechanical interactions in electrospun environments are reviewed, with emphasis on how fiber geometry and polymer structure impact on the local mechanical properties of scaffolds, how altering the micromechanics cues cell behaviors, and how, in turn, cellular and extrinsic forces exerted on the matrix mechanically remodel an electrospun scaffold throughout tissue development...
December 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28000609/an-in-vitro-3d-model-using-collagen-coated-gelatin-nanofibers-for-studying-breast-cancer-metastasis
#16
G Janani, Mamatha M Pillai, R Selvakumar, Amitava Bhattacharyya, C Sabarinath
The study of breast cancer metastasis is limited due to poor knowledge of molecular progression of breast tumor and varied heterogeneity. For a better understanding of tumor metastasis, a reliable 3D in vitro model bridging the gap between 2D cultures and in vivo animal model studies is essential. Our study is focused on two key points: (i) designing a 3D microenvironment for studying metastasis and (ii) simulating the metastasis milieu by inducing epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET)...
February 7, 2017: Biofabrication
https://www.readbyqxmd.com/read/27995587/roll-designed-3d-nanofibrous-scaffold-suitable-for-the-regeneration-of-load-bearing-bone-defects
#17
Fatemeh Hejazi, Hamid Mirzadeh
In this work, an innovative and easy method for the fabrication of 3D scaffold from 2D electrospun structures is introduced. For this aim, coral microparticles were fixed inside the nanofibrous PCL/Gelatin mat and the obtained structure was post assembled into a cylindrical design. Scaffold fabrication procedure is described in detail and morphological properties, physical and mechanical characteristics and in vitro assessments of the prepared scaffold are reported. Presences of coral microparticles in the structure led to the formation of empty spaces (3D pores) between nanofibrous layers which in turn prevent the compact accumulation of nanofibers...
December 2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27987890/fabrication-of-chitosan-polycaprolactone-composite-nanofibrous-scaffold-for-simultaneous-delivery-of-ferulic-acid-and-resveratrol
#18
Balan Poornima, Purna Sai Korrapati
Wound healing is a complex cellular process involving various mechanisms making it intricate for designing a scaffold for therapeutic use. This study deals with the designing and development of coaxial electrospun Chitosan-Polycaprolactone nanofiber wound dressings for efficient simultaneous drug delivery. Ferulic acid and resveratrol were chosen for incorporation into core-shell nanofibers for their efficacy in anti-inflammatory and pro-angiogenic activities respectively. Structural and physico-chemical characterization of the scaffold confirmed the encapsulation of both the molecules...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27987755/controlled-release-of-cefazolin-sodium-antibiotic-drug-from-electrospun-chitosan-polyethylene-oxide-nanofibrous-mats
#19
Yousef Fazli, Zahra Shariatinia
Antimicrobial electrospun chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing cefazolin, fumed silica (F. silica) and cefazolin-loaded fumed silica nanoparticles (NPs) were produced for biomedical applications. The FE-SEM images revealed that the F. silica and F. silica-cefazolin NPs had average diameters of 40±10 and 60±15nm, respectively. Also, the fibers diameters were approximately 160±30, 90±20 and 70±15nm for the pure CS-PEO, CS-PEO-1% F. silica and CS-PEO-1% F. silica-0.5% cefazolin nanofibrous mats, respectively indicating addition of F...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987753/sequel-of-mgo-nanoparticles-in-placl-nanofibers-for-anti-cancer-therapy-in-synergy-with-curcumin-%C3%AE-cyclodextrin
#20
Shruthi Vathaluru Sudakaran, Jayarama Reddy Venugopal, Gnaneshwar Puvala Vijayakumar, Sivasubramanian Abisegapriyan, Andrews Nirmala Grace, Seeram Ramakrishna
Pharmaceutical industries spend more money in developing new and efficient methods for delivering successful drugs for anticancer therapy. Electrospun nanofibers and nanoparticles loaded with drugs have versatile biomedical applications ranging from wound healing to anticancer therapy. We aimed to attempt for fabricating elastomeric poly (l-lactic acid-co-ε-caprolactone) (PLACL) with Aloe Vera (AV), magnesium oxide (MgO) nanoparticles, curcumin (CUR) and β-cyclodextrin (β-CD) composite nanofibers to control the growth of MCF-7 cells for breast cancer therapy...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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