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electrospun nanofibrous scaffold

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https://www.readbyqxmd.com/read/29901281/silk-nanofibrous-electrospun-scaffold-enhances-differentiation-of-embryonic-stem-like-cells-derived-from-testis-in-to-mature-neuron
#1
M Nazm Bojnordi, S Ebrahimi-Barough, E Vojoudi, H H Ghasemi
The scaffolds accompanied with stem cells have great potential for applications in neural tissue engineering. Fabrication of Nano fibrous scaffold similar to extracellular matrix is one of the applicable methods in neural tissue regeneration. The aim of this study was the fabrication of a silk Nano fibrous scaffold as a microenvironment for neural guiding differentiation of Embryonic stem like cells (ES Like cells) derived from testis toward neuron-like cells. ES Like derived from culturing of testicular cells in vitro, were seeded on Silk scaffolds and induced to neuronal phenotype using 4-/4± RA technique following culturing the cells in the neurobasal medium supplemented with 20 ng/ml bFGF,10 ng/ml EGF, B27 and N2 for 8-12 days...
June 14, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29886100/incorporating-platelet-rich-plasma-into-coaxial-electrospun-nanofibers-for-bone-tissue-engineering
#2
Gu Cheng, Yuming Du, Xiao Ma, Junmei Li, Yuet Cheng, Yan Cao, Ziming Wang, Xiaowen Shi, Hongbing Deng, Zubing Li
Platelet-rich plasma (PRP) is used in therapy for bone tissue repair because an abundance of osteogenesis-related growth factors can be released from the concentrated platelets. However, its clinical use is limited because growth factors, temporally released from PRP, are degraded rapidly. This study aimed to incorporate PRP-derived growth factors into SF/PCL/PVA nanofibers by coaxial electrospinning to determine the release profiles of growth factors and how the presence of these growth factors enhances the osteogenic abilities of the nanofibers...
June 7, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29884926/three-dimensional-nanofiber-scaffolds-are-superior-to-two-dimensional-mats-in-micro-oriented-extraction-of-chlorobenzenes
#3
Habib Bagheri, Faranak Manshaei, Omid Rezvani
Three-dimensional (3D) polyamide scaffolds were fabricated by applying a solvent bath as the collecting element. Electrospun nanofibers were immersed into the solvent bath to give a material with a laminated 3D texture. In parallel, 2D nanofibers were synthesized and utilized as microextractive phases in a needle trap device to compare the capabilities of 2D and 3D materials in terms of headspace extraction of various chlorobenzenes (chlorobenzene, 1,2-dichlorobenzene, 1,4-dichlorobenzene, 1,2,4-trichlorobenzene and 1,2,3,4-tetrachlorobenzene)...
June 8, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29883703/the-control-of-alginate-degradation-to-dynamically-manipulate-scaffold-composition-for-in-situ-transfection-application
#4
Wei-Wen Hu, Zhe-Chen Hu
In this study, nanofibrous scaffolds were used for in situ transfection application. Polyethylenimine (PEI)/DNA complexes adsorbed to alginate nanofibers, so the more alginate fibers resulted in the higher transfection efficiency. However, alginate was not favorable for cell adhesion. Therefore, poly (ε‑caprolactone) (PCL) nanofibers were electrospun with alginate to improve biocompatibility. The in situ transfection results demonstrated that although the incorporated PCL fibers effectively improved cell morphology, the bioactivity and proliferation rates of surface cells were not significantly increased due to the high ratio of alginate fibers...
June 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29881270/a-polypropylene-mesh-modified-with-poly-%C3%AE%C2%B5-caprolactone-nanofibers-in-hernia-repair-large-animal-experiment
#5
Barbora East, Martin Plencner, Martin Kralovic, Michala Rampichova, Vera Sovkova, Karolina Vocetkova, Martin Otahal, Zbynek Tonar, Yaroslav Kolinko, Evzen Amler, Jiri Hoch
Purpose: Incisional hernia repair is an unsuccessful field of surgery, with long-term recurrence rates reaching up to 50% regardless of technique or mesh material used. Various implants and their positioning within the abdominal wall pose numerous long-term complications that are difficult to treat due to their permanent nature and the chronic foreign body reaction they trigger. Materials mimicking the 3D structure of the extracellular matrix promote cell adhesion, proliferation, migration, and differentiation...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29875468/lycium-barbarum-polysaccharide-encapsulated-poly-lactic-co-glycolic-acid-nanofibers-cost-effective-herbal-medicine-for-potential-application-in-peripheral-nerve-tissue-engineering
#6
Jing Wang, Lingling Tian, Liumin He, Nuan Chen, Seeram Ramakrishna, Kwok-Fai So, Xiumei Mo
Nerve regeneration is a serious clinical challenge following peripheral nerve injury. Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable of serving as both drug delivery system and tissue engineering scaffolds, are well known to be suitable scaffolds for regeneration of peripheral nerve applications. In this study, LBP was incorporated into core-shell structured nanofibrous scaffolds via coaxial electrospinning...
June 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29843552/electrospun-poly-vinyl-alcohol-collagen-nanofibrous-scaffold-hybridized-by-graphene-oxide-for-accelerated-wound-healing
#7
Rethinam Senthil, Robert Berly, Thimmiah Bhargavi Ram, Nallathambi Gobi
PURPOSE: In this study, a blend of synthetic polymer (poly(vinyl) alcohol), natural polymer (collagen type I from fish bone), and graphene oxide nanoparticles is used to fabricate a composite nanofibrous scaffold, by electrospinning, for their potential application in accelerated wound healing. METHODS: The scaffold was characterized for its physicochemical and mechanical properties. In vitro studies were carried out using human keratinocyte cell line (HaCaT) which proved the biocompatibility of the scaffold...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29806201/cellular-interactions-with-bacterial-cellulose-polycaprolactone-nanofibrous-scaffolds-produced-by-a-portable-electrohydrodynamic-gun-for-point-of-need-wound-dressing
#8
Mehmet Onur Aydogdu, Esra Altun, Maryam Crabbe-Mann, Francis Brako, Fatma Koc, Gunes Ozen, Serap Erdem Kuruca, Ursula Edirisinghe, C J Luo, Oguzhan Gunduz, Mohan Edirisinghe
Electrospun nanofibrous scaffolds are promising regenerative wound dressing options but have yet to be widely used in practice. The challenge is that nanofibre productions rely on bench-top apparatuses, and the delicate product integrity is hard to preserve before reaching the point of need. Timing is critically important to wound healing. The purpose of this investigation is to produce novel nanofibrous scaffolds using a portable, hand-held "gun", which enables production at the wound site in a time-dependent fashion, thereby preserving product integrity...
May 27, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29804972/biomimetic-mineralization-of-carboxymethyl-chitosan-nanofibers-with-improved-osteogenic-activity-in-vitro-and-in-vivo
#9
Xiujuan Zhao, Liangyu Zhou, Qingtao Li, Qingxia Zou, Chang Du
Inspired by the natural extracellular matrix, the organic-inorganic composite nanofibers are promising scaffolds for bone tissue engineering. Chitosan-based nanofibers are widely used as bone tissue engineering scaffolds with good biocompatibility but pungent solvents are frequently used for its processing. Carboxymethyl chitosan (CMCS), a water-soluble derivative of chitosan, has better biodegradability and bioactivity which allows CMCS to chelate Ca2+ and induce the deposition of apatite. Moreover, with water as solvent, CMCS nanofibers avoid the acidic salt removal comparing to electrospun-chitosan...
September 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29797707/high-resolution-x-ray-tomographic-morphological-characterisation-of-electrospun-nanofibrous-bundles-for-tendon-and-ligament-regeneration-and-replacement
#10
A Sensini, L Cristofolini, M L Focarete, J Belcari, A Zucchelli, A Kao, G Tozzi
Repair of ligaments and tendons requires scaffolds mimicking the spatial organisation of collagen in the natural tissue. Electrospinning is a promising technique to produce nanofibres of both resorbable and biostable polymers with desired structural and morphological features. The aim of this study was to perform high-resolution x-ray tomography (XCT) scans of bundles of Nylon6.6, pure PLLA and PLLA-Collagen blends, where the nanofibres were meant to have a predominant direction. Characterisation was carried out via a dedicated methodology to firmly hold the specimen during the scan and a workflow to quantify the directionality of the nanofibres in the bundle...
May 25, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29768878/nano-nets-covered-composite-nanofibers-with-enhanced-biocompatibility-and-mechanical-properties-for-bone-tissue-engineering
#11
Arjun Prasad Tiwari, Mahesh Kumar Joshi, Chan Hee Park, Cheol Sang Kim
Enhancing the biocompatibility profiles including cell attachment, growth, and viability and mechanical properties of designed synthetic scaffolds have an essential role in tissue engineering applications. Polymer blending is one of the most effective methods for providing new anticipated biomaterials for tissue scaffolds. Here, the blend solution of the different mass weight ratio of polycaprolactone (PCL) to human serum albumin (HSA) was subjected to fabricate nanocomposite spider-web-like membranes using electrospinning process...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29719054/bone-tissue-engineering-adult-stem-cells-in-combination-with-electrospun-nanofibrous-scaffolds
#12
REVIEW
Sadegh L Moradi, Ali Golchin, Zahra Hajishafieeha, Mohammad-Mehdi Khani, Abdolreza Ardeshirylajimi
Since bone tissue lesions caused by several reasons and has global outbreak without any attentions to the modernity level of the countries. In the other hands treatment of patients with this problem faced to the several limitations, in this because the future of the bone lesions treatments is related to the future of the bone tissue engineering. This review tries to cover the most suitable stem cells and materials from either natural or synthetic sources for bone tissue engineering. These understanding points would help researchers to further uncover the application of different adult stem cell sources in electrospinning scaffolds, promotion of nanofibrous composite construct design and adult stem cell type selection to enhance cell function and bone tissue engineering, and link laboratory investigations to clinical applications...
May 2, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29701213/influence-of-the-nanofiber-chemistry-and-orientation-of-biodegradable-poly-butylene-succinate-based-scaffolds-on-osteoblast-differentiation-for-bone-tissue-regeneration
#13
Francesco Cristofaro, Matteo Gigli, Nora Bloise, Honglin Chen, Giovanna Bruni, Andrea Munari, Lorenzo Moroni, Nadia Lotti, Livia Visai
Innovative nanofibrous scaffolds have attracted considerable attention in bone tissue engineering, due to their ability to mimic the hierarchical architecture of an extracellular matrix. Aiming at investigating how the polymer chemistry and fiber orientation of electrospun scaffolds (ES) based on poly(butylene succinate) (PBS) and poly(butylene succinate/diglycolate) (P(BS80BDG20)) affect human osteoblast differentiation, uniaxially aligned (a-) and randomly (r-) distributed nanofibers were produced. Although human osteoblastic SAOS-2 cells were shown to be viable and adherent onto all ES materials, a-P(BS80BDG20) exhibited the best performance both in terms of cellular phosphorylated focal adhesion kinase expression and in terms of alkaline phosphatase activity, calcified bone matrix deposition and quantitative gene expression of bone specific markers during differentiation...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29691825/the-use-of-electrospinning-technique-on-osteochondral-tissue-engineering
#14
Marta R Casanova, Rui L Reis, Albino Martins, Nuno M Neves
Electrospinning, an electrostatic fiber fabrication technique, has attracted significant interest in recent years due to its versatility and ability to produce highly tunable nanofibrous meshes. These nanofibrous meshes have been investigated as promising tissue engineering scaffolds since they mimic the scale and morphology of the native extracellular matrix. The sub-micron diameter of fibers produced by this process presents various advantages like the high surface area to volume ratio, tunable porosity, and the ability to manipulate the nanofiber composition in order to get desired properties and functionality...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691819/nanofibers-and-microfibers-for-osteochondral-tissue-engineering
#15
Zaida Ortega, María Elena Alemán, Ricardo Donate
The use of fibers into scaffolds is a way to mimic natural tissues, in which fibrils are embedded in a matrix. The use of fibers can improve the mechanical properties of the scaffolds and may act as structural support for cell growth. Also, as the morphology of fibrous scaffolds is similar to the natural extracellular matrix, cells cultured on these scaffolds tend to maintain their phenotypic shape. Different materials and techniques can be used to produce micrfibers- and nanofibers for scaffolds manufacturing; cells, in general, adhere and proliferate very well on PCL, chitosan, silk fibroin, and other nanofibers...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29683273/micelle-coated-hierarchically-structured-nanofibers-with-dual-release-capability-for-accelerated-wound-healing-and-infection-control
#16
Victoria Albright, Meng Xu, Anbazhagan Palanisamy, Jun Cheng, Mary Stack, Beilu Zhang, Arul Jayaraman, Svetlana A Sukhishvili, Hongjun Wang
Tailoring nanofibrous matrices-a material with much promise for wound healing applications-to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocompatible micellar nanocarriers is reported. For wound healing, transforming growth factor-β1 is incorporated into polycaprolactone/collagen (PCL/Coll) nanofibers via electrospinning and the myofibroblastic differentiation of human dermal fibroblasts is locally stimulated...
June 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29680300/novel-poly-%C3%AE%C2%B5-caprolactone-amino-functionalized-tannin-electrospun-membranes-as-scaffolds-for-tissue-engineering
#17
Alessandro F Martins, Suelen P Facchi, Paulo C F da Câmara, Samira E A Camargo, Carlos H R Camargo, Ketul C Popat, Matt J Kipper
Poly(ε-caprolactone) (PCL) is a hydrophobic and cytocompatible aliphatic polyester that has been used to produce PCL-based nanofibrous for both wound healing and tissue repair. However, the high hydrophobicity and low water adsorptive have been challenges for developing PCL-based materials for use in tissue engineering field. Here, we report a new polymer (a hydrophilic amino-functionalized tannin (TN)) that is associated with PCL for developing PCL-TN blends at different PCL:TN weight ratios (100:0, 95:5, 85:15 and 78:22)...
September 1, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29649641/hydrogel-derived-from-porcine-decellularized-nerve-tissue-as-a-promising-biomaterial-for-repairing-peripheral-nerve-defects
#18
Tao Lin, Sheng Liu, Shihao Chen, Shuai Qiu, Zilong Rao, Jianghui Liu, Shuang Zhu, Liwei Yan, Haiquan Mao, Qingtang Zhu, Daping Quan, Xiaolin Liu
Decellularized matrix hydrogels derived from tissues or organs have been used for tissue repair due to their biocompatibility, tunability, and tissue-specific extracellular matrix (ECM) components. However, the preparation of decellularized peripheral nerve matrix hydrogels and their use to repair nerve defects have not been reported. Here, we developed a hydrogel from porcine decellularized nerve matrix (pDNM-G), which was confirmed to have minimal DNA content and retain collagen and glycosaminoglycans content, thereby allowing gelatinization...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29642582/synthesis-of-a-novel-electrospun-polycaprolactone-scaffold-functionalized-with-ibuprofen-for-periodontal-regeneration-an-in-vitro-andin-vivo-study
#19
Fareeha Batool, David-Nicolas Morand, Lionel Thomas, Isaac Maximiliano Bugueno, Javier Aragon, Silvia Irusta, Laetitia Keller, Nadia Benkirane-Jessel, Henri Tenenbaum, Olivier Huck
Ibuprofen (IBU) has been shown to improve periodontal treatment outcomes. The aim of this study was to develop a new anti-inflammatory scaffold by functionalizing an electrospun nanofibrous poly-ε-caprolactone membrane with IBU (IBU-PCL) and to evaluate its impact on periodontal inflammation, wound healing and regeneration in vitro and in vivo. IBU-PCL was synthesized through electrospinning. The effects of IBU-PCL on the proliferation and migration of epithelial cells (EC) and fibroblasts (FB) exposed to Porphyromonas gingivlais lipopolysaccharide (Pg -LPS) were evaluated through the AlamarBlue test and scratch assay, respectively...
April 10, 2018: Materials
https://www.readbyqxmd.com/read/29642421/nano-graphene-oxide-functionalized-bioactive-poly-lactic-acid-and-poly-%C3%AE%C2%B5-caprolactone-nanofibrous-scaffolds
#20
Duo Wu, Archana Samanta, Rajiv K Srivastava, Minna Hakkarainen
A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions...
April 6, 2018: Materials
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