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electrospun nanofibrous scaffold

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https://www.readbyqxmd.com/read/29048241/nanofibrous-electrospun-hdecm-based-hybrid-scaffold-as-wound-dressing-for-reducing-scarring
#1
Tae Hee Kim, Youngmee Jung, Soo Hyun Kim
Produced via electrospinning, poly(l-lactide-co-caprolactone) (PLCL) membranes, which have a porous structure and are biodegradable, are of interest in various medical fields. The porous-structured electrospun membrane is particularly interesting because of several favorable properties: it exudes fluid from the wound, does not build up under the wound covering, and does not cause wound desiccation. Moreover, extracellular matrix (ECM)-based structures derived by tissue decellularization have application as engineered tissue scaffolds and as supports for cellular regeneration...
October 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29043781/direct-writing-electrospinning-of-scaffolds-with-multi-dimensional-fiber-architecture-for-hierarchical-tissue-engineering
#2
Honglin Chen, Afonso de Botelho Ferreira Braga Malheiro, Clemens van Blitterswijk, Carlos Mota, Paul Andrew Wieringa, Lorenzo Moroni
Nanofibrous structures have long been used as scaffolds for tissue engineering (TE) applications, due to their favourable characteristics such as high porosity, flexibility, high cell attachment and enhanced proliferation, and overall resemblance to native extracellular matrix (ECM). Such scaffolds can be easily produced at a low cost via electrospinning (ESP), but generally cannot be fabricated with a regular and/or complex geometry, characterized by macropores and uniform thickness. We present here a novel technique for direct writing (DW) with solution ESP to produce complex three-dimensional (3D) multi-scale and ultrathin (~1 µm) fibrous scaffolds with desirable patterns and geometries...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29032216/gelatin-oxidized-carboxymethyl-cellulose-blend-based-tubular-electrospun-scaffold-for-vascular-tissue-engineering
#3
Jincy Joy, Jessica Pereira, Rachida Aid-Launais, Graciela Pavon-Djavid, Alok R Ray, Didier Letourneur, Anne Meddahi-Pellé, Bhuvanesh Gupta
The present work deals with the fabrication of electrospun tubular scaffold based on in-situ crosslinked blend of gelatin - oxidized carboxymethyl cellulose (OCMC) for vascular tissue engineering. The flow behavior and spinability of the hydrogel despite the in-situ crosslinked gelatin chains evaluated by Raman spectroscopic studies and rheological studies was utilized for electrospinning. The study highlights the tunable pore size and fiber diameter of the nanofibers with the manipulation of electrospinning parameters...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29027711/expansion-of-mesenchymal-stem-cells-on-electrospun-scaffolds-maintains-stemness-mechano-responsivity-and-differentiation-potential
#4
Su-Jin Heo, Spencer E Szczesny, Dong Hwa Kim, Kamiel S Saleh, Robert L Mauck
Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies and tissue engineering applications given their multipotential differentiation capacity. However, MSC isolation and expansion are typically performed on super-physiologically stiff tissue culture plastic (TCP), which may alter their behavior and lead to unintended consequences upon implantation. In contrast, electrospun nanofibrous scaffolds possess physical and mechanical properties that are similar to that of native tissue. In this study, we investigated whether isolation and expansion of juvenile bovine MSCs directly onto electrospun nanofibrous scaffolds better preserves MSC phenotype and stemness compared to TCP...
October 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29025656/dual-delivery-of-vegf-and-ngf-by-emulsion-electrospun-nanofibrous-scaffold-for-peripheral-nerve-regeneration
#5
Bin Xia, Yonggang Lv
Controlled delivery of multiple therapeutic agents can be considered an effective approach in nerve injury due to its multifunction. In this study, recombinant human vascular endothelial growth factor (VEGF) and recombinant human nerve growth factor (NGF) were loaded on the surface and in the core of emulsion electrospun poly (l-lactic acid) (PLLA) nanofibrous scaffold, respectively. The in vitro studies showed that VEGF and NGF had a sequential release pattern in which most of the VEFG was released in the first few days but the NGF could be continuously released for >1month...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28986947/in-vivo-diabetic-wound-healing-with-nanofibrous-scaffolds-modified-with-gentamicin-and-recombinant-human-epidermal-growth-factor
#6
Charu Dwivedi, Ishan Pandey, Himanshu Pandey, Sandip Patil, Shanti Bhushan Mishra, Avinash C Pandey, Paolo Zamboni, Pramod W Ramteke, Ajay Vikram Singh
Diabetic wounds are susceptible to microbial infection. The treatment of these wounds requires a higher payload of growth factors. With this in mind, the strategy for this study was to utilize a novel payload comprising of Eudragit RL/RS 100 nanofibers carrying the bacterial inhibitor gentamicin sulphate (GS) in concert with human epidermal growth factor (rhEGF); an accelerator of wound healing. GS containing Eudragit was electrospun to yield nanofiber scaffolds, which were further modified by covalent immobilization of rhEGF to their surface...
October 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28972553/bombyx-mori-silk-fibroin-scaffolds-with-antheraea-pernyi-silk-fibroin-micro-nano-fibers-for-promoting-ea-hy926-cell-proliferation
#7
Yongchun Chen, Weichao Yang, Weiwei Wang, Min Zhang, Mingzhong Li
Achieving a high number of inter-pore channels and a nanofibrous structure similar to that of the extracellular matrix remains a challenge in the preparation of Bombyx mori silk fibroin (BSF) scaffolds for tissue engineering. In this study, Antheraea pernyi silk fibroin (ASF) micro/nano fibers with an average diameter of 324 nm were fabricated by electrospinning from an 8 wt % ASF solution in hexafluoroisopropanol. The electrospun fibers were cut into short fibers (~0.5 mm) and then dispersed in BSF solution...
October 3, 2017: Materials
https://www.readbyqxmd.com/read/28967299/a-new-electrospun-graphene-silk-fibroin-composite-scaffolds-for-guiding-schwann-cells
#8
Yahong Zhao, Jiahuan Gong, Changmei Niu, Ziwei Wei, Jiaqi Shi, Guohui Li, Yumin Yang, Hongbo Wang
Graphene (Gr) has been made of various forms used for repairing peripheral nerve injury with favorable electroactivity, however, graphene-based scaffolds in peripheral nerve regeneration are still rarely reported due to the difficulty of realizing uniform dispersion of graphene and electroactive materials at nanoscale as well as lacking biocompatibility. In this paper, graphene-silk fibroin (SF) composite nanofiber membranes with different mass ratios were prepared via electrospinning. Microscopic observation revealed that electrospun Gr/SF membranes had a nanofibrous structure...
September 30, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28962783/nanofibrous-polysaccharide-hydroxyapatite-composites-with-biocompatibility-against-human-osteoblasts
#9
Petra Gašparič, Manja Kurečič, Rupert Kargl, Uroš Maver, Lidija Gradišnik, Silvo Hribernik, Karin Stana Kleinschek, Majda Sfiligoj Smole
Regenerative medicine has a high demand for defined scaffold materials that promote cell growth, stabilize the tissue during maturation and provide a proper three dimensional structure that allows the exchange of nutrients. In many instances nanofiber composites have already shown their potential for such applications. This work elaborates the development of polysaccharide based nanofibers with integrated hydroxyapatite nanoparticles. A detailed study on the formation of electrospun nanofibres from aqueous mixtures of carboxymethyl cellulose polyethylene oxide was performed...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28951331/design-development-and-characterization-of-synthetic-bruch-s-membranes
#10
Denver C Surrao, Ursula Greferath, Yu-Qian Chau, Stuart J Skabo, Mario Huynh, Kinnari J Shelat, Ioannis J Limnios, Erica L Fletcher, Qin Liu
Age-related macular degeneration (AMD) is a leading cause of blindness, and dry AMD has no effective treatment. Retinal constructs comprising retinal pigment epithelium (RPE) cells supported by electrospun scaffolds have been investigated to treat dry AMD. However, electrospun scaffolds studied to-date do not mimic the structural microenvironment of human Bruch's membrane (BM), essential for native-like RPE monolayers. The aim of this study was to develop a structurally biomimetic scaffold designed to support a functional RPE monolayer, comprising porous, electrospun nanofibrous membranes (ENMs), coated with laminin, mimicking the inner collagenous layer (ICL) and basal RPE lamina respectively, the cell supporting layers of the BM...
September 23, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28944539/nanofibrous-scaffolds-with-biomimetic-structure
#11
Shahla Khalili, Saied Nouri Khorasani, Mohammad Razavi, Batol Hashemi Beni, Fariba Heydari, Ali Tamayol
This research studies the effect of using a grid-like pattern as a collector on increasing the pore size of the electrospun gelatin/cellulose acetate/elastin scaffolds. The morphological study showed an enlargement in pore size and a decline in fiber diameter in comparison with the scaffold fabricated using conventional flat sheet collectors. The use of the pattern increased the swelling ratio and degradation rate of the scaffold. Investigating the tensile properties of scaffolds revealed that the patterned collector increased the elongation at break up to 145%...
September 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28925552/in-situ-bone-tissue-engineering-with-an-endogenous-stem-cell-mobilizer-and-osteoinductive-nanofibrous-polymeric-scaffolds
#12
Jong Seung Lee, Yoonhee Jin, Hyun-Ji Park, Kisuk Yang, Min Suk Lee, Hee Seok Yang, Seung-Woo Cho
Classical bone tissue engineering involves the use of culture-expanded cells and scaffolds to produce tissue constructs for transplantation. Despite promising results, clinical adoption of these constructs has been limited due to various drawbacks, including extensive cell expansion steps, low cell survival rate upon transplantation, and the possibility of immuno-rejection. To bypass the ex vivo cell culture and transplantation process, we exploited the regenerative capacity of the host by mobilizing endogenous stem cells to the site of injury...
September 19, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28919738/surface-modification-of-endovascular-stents-with-rosuvastatin-and-heparin-loaded-biodegradable-nanofibers-by-electrospinning
#13
Milka Janjic, Foteini Pappa, Varvara Karagkiozaki, Christakis Gitas, Kiriakos Ktenidis, Stergios Logothetidis
This study describes the development of drug-loaded nanofibrous scaffolds as a nanocoating for endovascular stents for the local and sustained delivery of rosuvastatin (Ros) and heparin (Hep) to injured artery walls after endovascular procedures via the electrospinning process. PURPOSE: The proposed hybrid covered stents can promote re-endothelialization; improve endothelial function; reduce inflammatory reaction; inhibit neointimal hyperplasia of the injured artery wall, due to well-known pleiotropic actions of Ros; and prevent adverse events such as in-stent restenosis (ISR) and stent thrombosis (ST), through the antithrombotic action of Hep...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28902474/electrospun-nanofibrous-meshes-cultured-with-wharton-s-jelly-stem-cell-an-alternative-for-cartilage-regeneration-without-the-need-of-growth-factors
#14
Marta Alves da Silva, Albino Martins, Ana R Costa-Pinto, Nélson Monteiro, Susana Faria, Rui L Reis, Nuno M Neves
Many efforts are being directed worldwide to the treatment of OA-focal lesions. The majority of those efforts comprise either the refinement of surgical techniques or combinations of biomaterials with various autologous cells. Herein, we tested electrospun polycaprolactone (PCL) nanofibrous meshes for cartilage tissue engineering. For that, articular chondrocytes (hACs) isolated from human osteoarthritic joints and Wharton's Jelly Stem Cells (hWJSCs) are cultured on electrospun nanofiber meshes, without adding external growth factors...
September 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28901994/biomineralized-conductive-pedot-pss-coated-pla-phbv-ha-nanofibrous-membranes
#15
Mohd Izzat Hassan, Noor Nabilah Masnawi, Naznin Sultana
Conductive materials are potential candidates for developing bone tissue engineering scaffolds as they are nontoxic and can enhance bone tissue regeneration. Their bioactivity can be enhanced by depositing biomineralization in simulated body fluid (SBF). In the current study, a composite electrospun membrane made up of poly(lactic) acid, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and hydroxyapatite was fabricated using an electrospinning method. The fabricated membranes were dip-coated with a conductive polymer solution, poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate), to induce conductivity...
September 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28876347/temporally-controlled-growth-factor-delivery-from-a-self-assembling-peptide-hydrogel-and-electrospun-nanofibre-composite-scaffold
#16
Kiara F Bruggeman, Yi Wang, Francesca L Maclean, Clare L Parish, Richard J Williams, David R Nisbet
Tissue-specific self-assembling peptide (SAP) hydrogels designed based on biologically relevant peptide sequences have great potential in regenerative medicine. These materials spontaneously form 3D networks of physically assembled nanofibres utilising non-covalent interactions. The nanofibrous structure of SAPs is often compared to that of electrospun scaffolds. These electrospun nanofibers are produced as sheets that can be engineered from a variety of polymers that can be chemically modified to incorporate many molecules including drugs and growth factors...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28875694/small-molecular-tgf-%C3%AE-1-inhibitor-loaded-electrospun-fibrous-scaffolds-for-preventing-hypertrophic-scars
#17
Le Wang, Junchuan Yang, Bei Ran, Xinglong Yang, Wenfu Zheng, Yunze Long, Xingyu Jiang
Hypertrophic scarring (HS) is a disorder that occurs during wound healing and seriously depresses the quality of human life. Scar-inhibiting scaffolds, though bringing promise to HS prevention, face problems such as the incompatibility of the scaffold materials and the instability of bioactive molecules. Herein, we present a TGF-β1-inhibitor-doped poly(ε-caprolactone) (PCL)/gelatin (PG) coelectrospun nanofibrous scaffold (PGT) for HS prevention during wound healing. The appropriate ratio of PCL to gelatin can avoid individual defects of the two materials and achieve an optimized mechanical property and biocompatibility...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28871656/fabrication-of-a-biomimetic-zeinpda-nanofibrous-scaffold-impregnated-with-bmp-2-peptide-conjugated-tio2-nanoparticle-for-bone-tissue-engineering
#18
Babitha Sekar, Meenakshi Annamalai, Michal Marcin Dykas, Surajit Saha, Kingshuk Poddar, Jayarama Reddy Venugopal, Seeram Ramakrishna, Thirumalai Venkatesan, Purna Sai Korrapati
A biomimetic Zein polydopamine (PDA) based nanofiber scaffold was fabricated to deliver bone morphogenic protein-2 (BMP-2) peptide conjugated titanium dioxide (TiO2 ) nanoparticles in a sustained manner for investigating its osteogenic differentiation potential. To prolong its retention time at the target site, BMP-2 peptide has been conjugated to TiO2 nanoparticles owing to its high surface to volume ratio. The effect of biochemical cues from BMP-2 peptide and nano topographical stimulation of electrospun Zein PDA nanofibers were examined for its enhanced osteogenic expression of human fetal osteoblast (hFOB) cells...
September 4, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28869428/preliminary-studies-of-pva-pvp-blends-incorporated-with-hap-and-%C3%AE-tcp-bone-ceramic-as-template-for-hard-tissue-engineering
#19
S Uma Maheshwari, K Govindan, M Raja, A Raja, M B S Pravin, S Vasanth Kumar
Polyvinylalcohol (PVA) and Polyvinylpyrrolidone (PVP) blend incorporated with hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) is electrospun as nanofibrous composite scaffolds to act as suitable template for bone tissue engineering. Microscopic and spectroscopic characterizations confirm uniform integration of the crystalline calcium phosphate ceramics in the scaffolds. PVA-PVP blends are usually amorphous in nature and addition of phosphate ceramic particles specifically HAp elevates its crystalline behavior which is substantiated by XRD details...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28866147/nanofibrous-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-collagen-graphene-oxide-scaffolds-for-wound-coverage
#20
Rashtrapal Zine, Mukty Sinha
The purpose of wound management is to prevent wound from infection, increase the fibroblast cell growth, and preserve cellular function. The polymeric electrospun nanofiber scaffold made up of natural and/or synthetic polymer provides an extracellular matrix for support and initiates the growth, proliferation and differentiation of fibroblast cells. The present study deals with the development of poly3-hydroxybutyric acid-co-3-hydroxyvaleric acid (PHBV) nanofibrous scaffold imbedded with graphene oxide (GO), and collagen...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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