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electrospun nanofibrous scaffold

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https://www.readbyqxmd.com/read/28817384/engineering-the-mechanical-and-biological-properties-of-nanofibrous-vascular-grafts-for-in-situ-vascular-tissue-engineering
#1
Jeffrey J D Henry, Jian Yu, Aijun Wang, Randall Lee, Jun Fang, Song Li
Synthetic small diameter vascular grafts have a high failure rate, and endothelialization is critical for preventing thrombosis and graft occlusion. A promising approach is in situ tissue engineering, whereby an acellular scaffold is implanted and provides stimulatory cues to guide the in situ remodeling into a functional blood vessel. An ideal scaffold should have sufficient binding sites for biomolecule immobilization and a mechanical property similar to native tissue. Here we developed a novel method to blend low molecular weight (LMW) elastic polymer during electrospinning process to increase conjugation sites and to improve the mechanical property of vascular grafts...
August 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/28813013/recent-advances-in-electrospun-nanofiber-interfaces-for-biosensing-devices
#2
REVIEW
Eleni Sapountzi, Mohamed Braiek, Jean-François Chateaux, Nicole Jaffrezic-Renault, Florence Lagarde
Electrospinning has emerged as a very powerful method combining efficiency, versatility and low cost to elaborate scalable ordered and complex nanofibrous assemblies from a rich variety of polymers. Electrospun nanofibers have demonstrated high potential for a wide spectrum of applications, including drug delivery, tissue engineering, energy conversion and storage, or physical and chemical sensors. The number of works related to biosensing devices integrating electrospun nanofibers has also increased substantially over the last decade...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28807566/electrospun-collagen-based-nanofibres-a-sustainable-material-for-improved-antibiotic-utilisation-in-tissue-engineering-applications
#3
Ivan J Hall Barrientos, Eleonora Paladino, Peter Szabó, Sarah Brozio, Peter J Hall, Charles I Oseghale, Melissa K Passarelli, Susan J Moug, Richard A Black, Clive G Wilson, Romana Zelkó, Dimitrios A Lamprou
For the creation of scaffolds in tissue engineering applications, it is essential to control the physical morphology of fibres and to choose compositions which do not disturb normal physiological function. Collagen, the most abundant protein in the human body, is a well-established biopolymer used in electrospinning compositions. It shows high in-vivo stability and is able to maintain a high biomechanical strength over time. In this study, the effects of collagen type I in polylactic acid-drug electrospun scaffolds for tissue engineering applications are examined...
August 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28805042/fabrication-and-characterization-of-electrospun-laminin-functionalized-silk-fibroin-poly-ethylene-oxide-nanofibrous-scaffolds-for-peripheral-nerve-regeneration
#4
Mina Rajabi, Masoumeh Firouzi, Zahra Hassannejad, Ismaeil Haririan, Payam Zahedi
The peripheral nerve regeneration is still one of the major clinical problems, which has received a great deal of attention. In this study, the electrospun silk fibroin (SF)/poly(ethylene oxide) (PEO) nanofibrous scaffolds were fabricated and functionalized their surfaces with laminin (LN) without chemical linkers for potential use in the peripheral nerve tissue engineering. The morphology, surface chemistry, thermal behavior and wettability of the scaffolds were examined to evaluate their performance by means of scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and water contact angle (WCA) measurements, respectively...
August 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28802205/evaluation-of-electrospinning-parameters-on-the-tensile-strength-and-suture-retention-strength-of-polycaprolactone-nanofibrous-scaffolds-through-surface-response-methodology
#5
Zahra Asvar, Esmaeil Mirzaei, Negar Azarpira, Bita Geramizadeh, Milad Fadaie
Scaffolds should provide sufficient biomechanical support during tissue regeneration for tissue engineering (TE) applications. Electrospun scaffolds are commonly applied in TE applications due to their tunable physical, chemical, and mechanical properties as well as their similarity to extracellular matrix. Although the mechanical properties of electrospun scaffolds are highly dependent on processing parameters, a limited number of studies have systematically investigated this subject. The present study has investigated the effects of the main electrospinning parameters on tensile and suture retention strength of polycaprolactone (PCL) scaffolds using response surface methodology...
August 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28801095/fabrication-of-chitosan-poly-lactic-acid-graphene-oxide-tio2-composite-nanofibrous-scaffolds-for-sustained-delivery-of-doxorubicin-and-treatment-of-lung-cancer
#6
Saman Samadi, Mahboubeh Moradkhani, Hoda Beheshti, Mohammad Irani, Majid Aliabadi
In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds...
August 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28800464/accelerated-biomineralization-of-graphene-oxide-incorporated-cellulose-acetate-nanofibrous-scaffolds-for-mesenchymal-stem-cell-osteogenesis
#7
Xiaoyun Liu, He Shen, Saijie Song, Wei Chen, Zhijun Zhang
For bone tissue engineering, it requires that the scaffolds have excellent biocompatibility, proper mechanical and osteoinductive properties. Electrospun nanofibers with extracellular matrices mimicking structure have proven to be good scaffolds for bone tissue repairing. Hybrid nanofibers in particular, endow the nanofibers with specific and multiple functionalities, and therefore have attracted increasing interests in the recent years. In this study, we fabricated graphene oxide (GO)-incorporated cellulose acetate (CA) nanofibrous scaffolds by electrospinning technique for enhancement of biomineralization and osteogenic differentiation of human mesenchymal stem cells (hMSCs)...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28792664/collagen-coated-nano-electrospun-pcl-seeded-with-human-endometrial-stem-cells-for-skin-tissue-engineering-applications
#8
Shiva Sharif, Jafar Ai, Mahmoud Azami, Javad Verdi, Mohammad Ali Atlasi, Sadegh Shirian, Ali Samadikuchaksaraei
Human endometrial stem cells (hEnSCs) are known as an attractive source of stem cells for regenerative medicine. hEnSCs are easily isolated and are capable of repairing uterine through their strong ability of creating new capillaries. In this study, a three-dimensional (3D) nanofibrous polycaprolactone (PCL)/collagen scaffold was fabricated and characterized in order to be applied as a new approach for skin reconstruction. Furthermore, the behavior of hEnSCs on this scaffold was investigated. First, a PCL 3D scaffold was constructed using electrospinning technique...
August 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28777137/natural-compounds-for-skin-tissue-engineering-by-electrospinning-of-nylon-beta-vulgaris
#9
Parviz Ranjbarvan, Matin Mahmoudifard, Mousa Kehtari, Ali Babaie, Shokoh Hamedi, Samaneh Mirzaei, Masoud Soleimani, Simzar Hosseinzadeh
Natural compounds containing polysaccharide ingredients have been employed as candidates for treatment of skin tissue. Herein, for the first time, electrospinning setup was proposed to fabricate an efficient composite nanofibrous structure of Beta vulgaris (obtained from Beet [Chenopodiaceae or Amaranthaceae]) belonged to polysaccharides and an elastic polymer named nylon 66 for skin tissue engineering. Both prepared scaffolds including noncomposite and composite types were studied by Scanning electron microscope (SEM), FTIR spectroscopy, mechanical assay, and contact angle...
August 2, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28759856/high-flux-ultrafiltration-membrane-based-on-electrospun-polyacrylonitrile-nanofibrous-scaffolds-for-arsenate-removal-from-aqueous-solutions
#10
Pegah Bahmani, Afshin Maleki, Hiua Daraei, Mehrdad Khamforoush, Reza Rezaee, Fardin Gharibi, Alexey G Tkachev, Alexander E Burakov, Shilpi Agarwal, Vinod Kumar Gupta
Arsenic contamination in drinking water is a serious problem worldwide. In this study, to remove arsenate from contaminated water, a new thin-film composite (TFC) membrane was fabricated and tested. This membrane was composed of an electrospun nanofibrous scaffold, a polyethylene terephthalate (PET) substrate as support, and a polyacrylonitrile (PAN) coating layer. To effectively reject arsenate ions, cetylpyridinium chloride (CPC) pretreatment was used. For evaluating the performance of TFC membrane, its flux and contaminant rejection were compared to a conventional ultrafiltration (UF) membrane...
July 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28737465/the-effect-of-ozone-gas-sterilization-on-the-properties-and-cell-compatibility-of-electrospun-polycaprolactone-scaffolds
#11
Carolina Fracalossi Rediguieri, Paul A De Bank, Maria Helena Ambrosio Zanin, Patrícia Leo, Natalia Neto Pereira Cerize, Adriano Marim de Oliveira, Terezinha de Jesus Andreoli Pinto
The growing area of tissue engineering has the potential to alleviate the shortage of tissues and organs for transplantation, and electrospun biomaterial scaffolds are extremely promising devices for translating engineered tissues into a clinical setting. However, to be utilized in this capacity, these medical devices need to be sterile. Traditional methods of sterilization are not always suitable for biomaterials, especially as many commonly used biomedical polymers are sensitive to chemical-, thermal- or radiation-induced damage...
July 24, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28721664/reciprocal-influence-of-hmscs-hacat-cultivated-on-electrospun-scaffolds
#12
Sirsendu Bhowmick, Sandra Rother, Heike Zimmermann, Poh S Lee, Stephanie Moeller, Matthias Schnabelrauch, Veena Koul, Dieter Scharnweber
Here, we investigated the synergistic effect of electrospun nanofibrous scaffolds made of gelatin /sulfated hyaluronan (sHA) or native hyaluronan (HA)/chondroitin sulfate (CS) and, keratinocytes (HaCaT)-human mesenchymal stem cells (hMSCs) contact co-culture on epithelial differentiation of hMSCs. The hMSCs were co-cultured in contact with HaCaT cells for 5 days on electrospun scaffold. Results show that electrospun scaffolds containing sulfated glycosaminoglycans (GAGs) stimulate epithelial differentiation in terms of various protein expression markers (keratin 14, ΔNp63α and Pan-cytokeratin) and gene expression of several dermal proteins (keratin 14, ΔNp63α)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28718680/development-of-emu-oil-loaded-pcl-collagen-bioactive-nanofibers-for-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cell-possible-application-in-regenerative-medicine
#13
Kazem Nejati-Koshki, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Abbas Ebrahimi-Kalan, Yousef Mortazavi, Nosratollah Zarghami
Adipose tissue-derived stem cells (ASCs) are promising candidate in stem cell therapies, and maintaining their stemness potential is vital to achieve effective treatment. Natural based scaffolds have been recently attracted increasing attention in nanomedicine and drug delivery. In the present study, a polymeric nanofibrous scaffold was developed based on the polycaprolactone/Collagen (PCL/Coll) containing Emu oil as a bioactive material to induce the proliferation of ASCs, while simultaneously preserve the stemness property of those cells...
July 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28714176/osteogenic-differentiation-of-3d-cultured-mesenchymal-stem-cells-induced-by-bioactive-peptides
#14
Vera Lukasova, Matej Buzgo, Vera Sovkova, Jana Dankova, Michala Rampichova, Evzen Amler
OBJECTIVES: Bioactive peptides derived from receptor binding motifs of native proteins are a potent source of bioactive molecules that can induce signalling pathways. These peptides could substitute for osteogenesis promoting supplements. The work presented here compares three kinds of bioactive peptides derived from collagen III, bone morphogenetic protein 7 (BMP-7) and BMP-2 with their potential osteogenic activity on the model of porcine mesenchymal stem cells (pMSCs). MATERIALS AND METHODS: pMSCs were cultured on electrospun polycaprolactone nanofibrous scaffolds with different concentrations of the bioactive peptides without addition of any osteogenic supplement...
August 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28702219/modification-and-optimization-of-electrospun-gelatin-sheets-by-electron-beam-irradiation-for-soft-tissue-engineering
#15
Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park, Oh Hyeong Kwon
BACKGROUND: Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell migration and tissue regeneration. Here, we investigated the optimal electron beam (e-beam) irradiation doses with biodegradation behavior on changes in the molecular weight, morphology, pore structure, and cell proliferation profiles of electrospun nanofibrous gelatin sheets...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28695751/watercress-based-electrospun-nanofibrous-scaffolds-enhance-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cells
#16
Mehdi Dadashpour, Younes Pilehvar-Soltanahmadi, Seyed Abolghasem Mohammadi, Nosratollah Zarghami, Mohammad Pourhassan-Moghaddam, Effat Alizadeh, Mohammad Jafar Maleki, Akram Firouzi-Amandi, Mohammad Nouri
The present study describes the effects of Watercress extract (WE) based electrospun nanofibrous mats on the regulation of adhesion, proliferation, cytoprotection and stemness preservation of adipose-derived stem cells (ADSCs). Watercress (Nasturtium officinale) is one of the most important medicinal plant with a board spectrum of biological functions. For this purpose, WE-loaded PCL-PEG nanofibers were fabricated by electrospinning and characterized using FE-SEM and FTIR. Adhesion, proliferation and cytoprotection of ADSCs on the nanofibers was investigated using FE-SEM and MTT assays...
July 11, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28694826/magnesium-oxide-nanoparticles-reinforced-electrospun-alginate-based-nanofibrous-scaffolds-with-improved-physical-properties
#17
R T De Silva, M M M G P G Mantilaka, K L Goh, S P Ratnayake, G A J Amaratunga, K M Nalin de Silva
Mechanically robust alginate-based nanofibrous scaffolds were successfully fabricated by electrospinning method to mimic the natural extracellular matrix structure which benefits development and regeneration of tissues. Alginate-based nanofibres were electrospun from an alginate/poly(vinyl alcohol) (PVA) polyelectrolyte complex. SEM images revealed the spinnability of the complex composite nanofibrous scaffolds, showing randomly oriented, ultrafine, and virtually defects-free alginate-based/MgO nanofibrous scaffolds...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28678733/preparation-characterization-and-blood-compatibility-assessment-of-a-novel-electrospun-nanocomposite-comprising-polyurethane-and-ayurvedic-indhulekha-oil-for-tissue-engineering-applications
#18
Manikandan Ayyar, Mohan Prasath Mani, Saravana Kumar Jaganathan, Rajasekar Rathanasamy
Electrospun polyurethane based nanocomposite scaffolds were fabricated by mixing with indhulekha oil. Scanning electron microscope (SEM) portrayed the nanofibrous nature of the composite and the average diameters of the composite scaffold were smaller than the pristine scaffolds. The fabricated scaffold was found to be hydrophobic (114°) due to the inclusion of indhulekha oil, which was displayed in contact angle measurement analysis. The fourier transform infrared spectroscopy (FTIR) results indicated that the indhulekha oil was dispersed in PU matrix identified by formation of hydrogen bond and peak shifting of CH group...
July 5, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28663141/electrospun-conductive-nanofibrous-scaffolds-for-engineering-cardiac-tissue-and-3d-bioactuators
#19
Ling Wang, Yaobin Wu, Tianli Hu, Baolin Guo, Peter X Ma
Mimicking the nanofibrous structure similar to extracellular matrix and conductivity for electrical propagation of native myocardium would be highly beneficial for cardiac tissue engineering and cardiomyocytes-based bioactuators. Herein, we developed conductive nanofibrous sheets with electrical conductivity and nanofibrous structure composed of poly(l-lactic acid) (PLA) blending with polyaniline (PANI) for cardiac tissue engineering and cardiomyocytes-based 3D bioactuators. Incorporating of varying contents of PANI from 0wt% to 3wt% into the PLA polymer, the electrospun nanofibrous sheets showed enhanced conductivity while maintaining the same fiber diameter...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28658997/evaluation-of-the-potential-of-kartogenin-encapsulated-poly-l-lactic-acid-co-caprolactone-collagen-nanofibers-for-tracheal-cartilage-regeneration
#20
Haiyue Yin, Juan Wang, Ziqi Gu, Wenhao Feng, Manchen Gao, Yu Wu, Hao Zheng, Xiaomin He, Xiumei Mo
Tracheal stenosis is one of major challenging issues in clinical medicine because of the poor intrinsic ability of tracheal cartilage for repair. Tissue engineering provides an alternative method for the treatment of tracheal defects by generating replacement tracheal structures. In this study, we fabricated coaxial electrospun fibers using poly(L-lactic acid-co-caprolactone) and collagen solution as shell fluid and kartogenin solution as core fluid. Scanning electron microscope and transmission electron microscope images demonstrated that nanofibers had uniform and smooth structure...
January 1, 2017: Journal of Biomaterials Applications
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