keyword
MENU ▼
Read by QxMD icon Read
search

electrospun nanofibrous scaffold

keyword
https://www.readbyqxmd.com/read/28087448/fabrication-and-characterization-of-electrospun-cellulose-nano-hydroxyapatite-nanofibers-for-bone-tissue-engineering
#1
Chenghong Ao, Yan Niu, Ximu Zhang, Xu He, Wei Zhang, Canhui Lu
Nanofibrous scaffolds from cotton cellulose and nano-hydroxyapatite (nano-HA) were electrospun for bone tissue engineering. The solution properties of cellulose/nano-HA spinning dopes and their associated electrospinnability were characterized. Morphological, thermal and mechanical properties of the electrospun cellulose/nano-HA nanocomposite nanofibers (ECHNN) were measured and the biocompatibility of ECHNN with human dental follicle cells (HDFCs) was evaluated. Scanning electron microscope (SEM) images indicated that the average diameter of ECHNN increased with a higher nano-HA loading and the fiber diameter distributions were well within the range of natural ECM (extra cellular matrix) fibers (50-500nm)...
January 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28071988/braided-and-stacked-electrospun-nanofibrous-scaffolds-for-tendon-and-ligament-tissue-engineering
#2
Benjamin B Rothrauff, Brian B Lauro, Guang Yang, Richard E Debski, Volker Musahl, Rocky Tuan
Tendon and ligament injuries are a persistent orthopaedic challenge given their poor innate healing capacity. Non-woven electrospun nanofibrous scaffolds composed of polyesters have been used to mimic the mechanics and topographical cues of native tendons and ligaments. However, non-woven nanofibers have several limitations that prevent broader clinical application, including poor cell infiltration as well as tensile and suture-retention strengths that are inferior to native tissues. In this study, multilayered scaffolds of aligned electrospun nanofibers of two designs - stacked or braided - were fabricated...
January 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28011142/cell-matrix-mechanical-interaction-in-electrospun-polymeric-scaffolds-for-tissue-engineering-implications-for-scaffold-design-and-performance
#3
REVIEW
Kelsey M Kennedy, Archana Bhaw-Luximon, Dhanjay Jhurry
: Engineered scaffolds produced by electrospinning of biodegradable polymers offer a 3D, nanofibrous environment with controllable structural, chemical, and mechanical properties that mimic the extracellular matrix of native tissues and have shown promise for a number of tissue engineering applications. The microscale mechanical interactions between cells and electrospun matrices drive cell behaviors including migration and differentiation that are critical to promote tissue regeneration...
December 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28000609/an-i-in-vitro-i-3d-model-using-collagen-coated-gelatin-nanofibers-for-studying-breast-cancer-metastasis
#4
Janani Guru, Mamatha Pillai, Selvakumar Rajendran, Amitava Bhattacharyya, Sabarinath Chandrasekharan
Study of breast cancer metastasis is limited due to poor knowledge in molecular progression of breast tumor and varied heterogeneity. For better understanding of tumor metastasis, a reliable 3D <i>in vitro</i> model bridging the gap between 2D cultures and <i>in vivo</i> animal model studies is highly needed. Our study is focused on two keypoints (i) designing a 3D microenvironment for studying metastasis and (ii) simulating the metastasis milieu by inducing epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET)...
December 21, 2016: Biofabrication
https://www.readbyqxmd.com/read/27995587/roll-designed-3d-nanofibrous-scaffold-suitable-for-the-regeneration-of-load-bearing-bone-defects
#5
Fatemeh Hejazi, Hamid Mirzadeh
In this work, an innovative and easy method for the fabrication of 3D scaffold from 2D electrospun structures is introduced. For this aim, coral microparticles were fixed inside the nanofibrous PCL/Gelatin mat and the obtained structure was post assembled into a cylindrical design. Scaffold fabrication procedure is described in detail and morphological properties, physical and mechanical characteristics and in vitro assessments of the prepared scaffold are reported. Presences of coral microparticles in the structure led to the formation of empty spaces (3D pores) between nanofibrous layers which in turn prevent the compact accumulation of nanofibers...
December 2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27987890/fabrication-of-chitosan-polycaprolactone-composite-nanofibrous-scaffold-for-simultaneous-delivery-of-ferulic-acid-and-resveratrol
#6
Balan Poornima, Purna Sai Korrapati
Wound healing is a complex cellular process involving various mechanisms making it intricate for designing a scaffold for therapeutic use. This study deals with the designing and development of coaxial electrospun Chitosan-Polycaprolactone nanofiber wound dressings for efficient simultaneous drug delivery. Ferulic acid and resveratrol were chosen for incorporation into core-shell nanofibers for their efficacy in anti-inflammatory and pro-angiogenic activities respectively. Structural and physico-chemical characterization of the scaffold confirmed the encapsulation of both the molecules...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27987755/controlled-release-of-cefazolin-sodium-antibiotic-drug-from-electrospun-chitosan-polyethylene-oxide-nanofibrous-mats
#7
Yousef Fazli, Zahra Shariatinia
Antimicrobial electrospun chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing cefazolin, fumed silica (F. silica) and cefazolin-loaded fumed silica nanoparticles (NPs) were produced for biomedical applications. The FE-SEM images revealed that the F. silica and F. silica-cefazolin NPs had average diameters of 40±10 and 60±15nm, respectively. Also, the fibers diameters were approximately 160±30, 90±20 and 70±15nm for the pure CS-PEO, CS-PEO-1% F. silica and CS-PEO-1% F. silica-0.5% cefazolin nanofibrous mats, respectively indicating addition of F...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987753/sequel-of-mgo-nanoparticles-in-placl-nanofibers-for-anti-cancer-therapy-in-synergy-with-curcumin-%C3%AE-cyclodextrin
#8
Shruthi Vathaluru Sudakaran, Jayarama Reddy Venugopal, Gnaneshwar Puvala Vijayakumar, Sivasubramanian Abisegapriyan, Andrews Nirmala Grace, Seeram Ramakrishna
Pharmaceutical industries spend more money in developing new and efficient methods for delivering successful drugs for anticancer therapy. Electrospun nanofibers and nanoparticles loaded with drugs have versatile biomedical applications ranging from wound healing to anticancer therapy. We aimed to attempt for fabricating elastomeric poly (l-lactic acid-co-ε-caprolactone) (PLACL) with Aloe Vera (AV), magnesium oxide (MgO) nanoparticles, curcumin (CUR) and β-cyclodextrin (β-CD) composite nanofibers to control the growth of MCF-7 cells for breast cancer therapy...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987671/role-of-solvent-mediated-carbodiimide-cross-linking-in-fabrication-of-electrospun-gelatin-nanofibrous-membranes-as-ophthalmic-biomaterials
#9
Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai, David Hui-Kang Ma
Due to their ability to mimic the structure of extracellular matrix, electrospun gelatin nanofibers are promising cell scaffolding materials for tissue engineering applications. However, the hydrophilic gelatin molecules usually need stabilization before use in aqueous physiological environment. Considering that biomaterials cross-linked via film immersion technique may have a more homogeneous cross-linked structure than vapor phase cross-linking, this work aims to investigate the chemical modification of electrospun gelatin nanofibrous membranes by liquid phase carbodiimide in the presence of ethanol/water co-solvents with varying ethanol concentrations ranging from 80 to 99...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27931176/in-vitro-evaluation-of-electrospun-silk-fibroin-nano-hydroxyapatite-bmp-2-scaffolds-for-bone-regeneration
#10
Bingjie Niu, Bin Li, Yong Gu, Xiaofeng Shen, Yong Liu, Liang Chen
Bone tissue engineering by using osteoinductive scaffolds seeded with stem cells to promote bone extracellular matrix (ECM) production and remodeling has evolved into a promising approach for bone repair and regeneration. In order to mimic the ECM of bone tissue structurally and compositionally, nanofibrous silk fibroin (SF) scaffolds containing hydroxyapatite (HAP) nanoparticles and bone morphogenetic protein 2 (BMP-2) were fabricated in this study using electrospinning technique. The microstructure, mechanical property, biocompatibility, and osteogenic characteristics were examined...
February 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27904497/preparation-of-polypyrrole-embedded-electrospun-poly-lactic-acid-nanofibrous-scaffolds-for-nerve-tissue-engineering
#11
Jun-Feng Zhou, Yi-Guo Wang, Liang Cheng, Zhao Wu, Xiao-Dan Sun, Jiang Peng
Polypyrrole (PPy) is a biocompatible polymer with good conductivity. Studies combining PPy with electrospinning have been reported; however, the associated decrease in PPy conductivity has not yet been resolved. We embedded PPy into poly(lactic acid) (PLA) nanofibers via electrospinning and fabricated a PLA/PPy nanofibrous scaffold containing 15% PPy with sustained conductivity and aligned topography. There was good biocompatibility between the scaffold and human umbilical cord mesenchymal stem cells as well as Schwann cells...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27886552/three-dimensional-electrospun-pcl-pla-blend-nanofibrous-scaffolds-with-significantly-improved-stem-cells-osteogenic-differentiation-and-cranial-bone-formation
#12
Qingqing Yao, Jaqueline G L Cosme, Tao Xu, Jacob M Miszuk, Paulo H S Picciani, Hao Fong, Hongli Sun
Nanofibrous scaffolds that are morphologically/structurally similar to natural ECM are highly interested for tissue engineering; however, the electrospinning technique has the difficulty in directly producing clinically relevant 3D nanofibrous scaffolds with desired structural properties. To address this challenge, we have developed an innovative technique of thermally induced nanofiber self-agglomeration (TISA) recently. The aim of this work was to prepare (via the TISA technique) and evaluate 3D electrospun PCL/PLA blend (mass ratio: 4/1) nanofibrous scaffolds having high porosity of ∼95...
January 2017: Biomaterials
https://www.readbyqxmd.com/read/27877111/polymerizing-pyrrole-coated-poly-l-lactic-acid-co-%C3%AE%C2%B5-caprolactone-plcl-conductive-nanofibrous-conduit-combined-with-electric-stimulation-for-long-range-peripheral-nerve-regeneration
#13
Jialin Song, Binbin Sun, Shen Liu, Wei Chen, Yuanzheng Zhang, Chunyang Wang, Xiumei Mo, Junyi Che, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Electrospinning and electric stimulation (ES) are both promising methods to support neuron adhesion and guide extension of neurons for nerve regeneration. Concurrently, all studies focus on either electrospinning for conduits material or ES in vitro study to accelerate nerve regeneration; few work on the combined use of these two strategies or ES in vivo study. Therefore, this study aimed to investigate the abilities of direct current ES through electrospinning conductive polymer composites composed of polypyrrole and Poly (l-lactic acid-co-ε-caprolactone) (PPY/PLCL) in peripheral nerve regeneration...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27857724/nanobiomaterials-for-neural-regeneration
#14
REVIEW
Nuan Chen, Lingling Tian, Liumin He, Seeram Ramakrishna
Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the lost body part may be regenerated or even fully rebuilt. Electrospinning, being able to produce extracellular matrix (ECM)-like nanostructures with great flexibility in design and choice of materials, have demonstrated their great potential for fabrication of nerve tissue engineered scaffolds...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27772719/photosensitive-semiconducting-polymer-incorporated-nanofibers-for-promoting-the-regeneration-of-skin-wound
#15
Guorui Jin, Jun Li, Kai Li
Photosensitive semiconducting polymer (SP) combined with light stimulation has shown the capability in promoting the proliferation of human dermal fibroblasts (HDFs). However, the high cytotoxicity of the used SP hindered its further application in bioactive scaffolds. In this contribution, we designed and synthesized a SP, poly (N,N-bis(2-octyldodecyl)-3,6-di(thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione-alt-thieno[3,2-b]thiophene) (PDBTT) with low cytotoxicity and strong absorbance in red and near-infrared region (600-1200nm)...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770955/intermolecular-interactions-between-b-mori-silk-fibroin-and-poly-l-lactic-acid-in-electrospun-composite-nanofibrous-scaffolds
#16
Paola Taddei, Silvia Tozzi, Giampaolo Zuccheri, Simona Martinotti, Elia Ranzato, Valeria Chiono, Irene Carmagnola, Masuhiro Tsukada
In this study, composite nanofibrous scaffolds were obtained by electrospinning a trifluoroacetic acid solution containing B. mori silk fibroin (SF) and poly(l-lactic acid) (PLLA) in a 1:1 weight ratio. SF, PLLA and SF/PLLA nanofibres were prepared with average diameter sizes of 360±90nm, 470±240nm and 580±220nm, respectively, as assessed by SEM analysis. Vibrational and thermal analyses showed that upon blending in the SF/PLLA nanofibres, the crystallisation of PLLA was hindered by the presence of SF, which crystallized preferentially and underwent conformational changes that did not significantly change its prevailing β-sheet structure...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770924/development-of-highly-porous-biodegradable-%C3%AE-fe2o3-polyvinyl-alcohol-nanofiber-mats-using-electrospinning-process-for-biomedical-application
#17
Nor Hasrul Akhmal Ngadiman, Noordin Mohd Yusof, Ani Idris, Effaliza Misran, Denni Kurniawan
The use of electrospinning process in fabricating tissue engineering scaffolds has received great attention in recent years due to its simplicity. The nanofibers produced via electrospinning possessed morphological characteristics similar to extracellular matrix of most tissue components. Porosity plays a vital role in developing tissue engineering scaffolds because it influences the biocompatibility performance of the scaffolds. In this study, maghemite (γ-Fe2O3) was mixed with polyvinyl alcohol (PVA) and subsequently electrospun to produce nanofibers...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770923/in-situ-synthesis-of-magnetic-iron-oxide-nanoparticle-nanofibre-composites-using-electrospinning
#18
Luke Burke, Chris J Mortimer, Daniel J Curtis, Aled R Lewis, Rhodri Williams, Karl Hawkins, Thierry G G Maffeis, Chris J Wright
We demonstrate a facile, one-step process to form polymer scaffolds composed of magnetic iron oxide nanoparticles (MNPs) contained within electrospun nano- and micro-fibres of two biocompatible polymers, Poly(ethylene oxide) (PEO) and Poly(vinyl pyrrolidone) (PVP). This was achieved with both needle and free-surface electrospinning systems demonstrating the scalability of the composite fibre manufacture; a 228 fold increase in fibre fabrication was observed for the free-surface system. In all cases the nanoparticle-nanofibre composite scaffolds displayed morphological properties as good as or better than those previously described and fabricated using complex multi-stage techniques...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27769929/polyethylenimine-silk-fibroin-multilayers-deposited-nanofibrics-for-cell-culture
#19
Xinguo Ye, Sheng Li, Xuanxuan Chen, Yingfei Zhan, Xiaonan Li
Scaffold with good three-dimensional (3D) structure and appropriate surface modification is essential to tissue regeneration in the treatment of tissue or organ failure. Silk fibroin (SF) is a promising scaffolding material with high biocompatibility, cytocompatibility, biodegradability and flexibility. In this study, positively charged polyethylenimine (PEI) and negatively charged SF assembled alternately onto cellulose nanofibrous substrates hydrolyzed from electrospun cellulose acetate nanofibrous mats. The obtained nanofibrous membranes modified with multiple layers of PEI/SF were characterized by field emission scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27730256/silk-pva-hybrid-nanofibrous-scaffolds-for-enhanced-primary-human-meniscal-cell-proliferation
#20
Mamatha M Pillai, J Gopinathan, B Indumathi, Y R Manjoosha, K Santosh Sahanand, B K Dinakar Rai, R Selvakumar, Amitava Bhattacharyya
In this study, silk fibroin nanofibrous scaffolds were developed to investigate the attachment and proliferation of primary human meniscal cells. Silk fibroin (SF)-polyvinyl alcohol (PVA) blended electrospun nanofibrous scaffolds with different blend ratios (2:1, 3:1, and 4:1) were prepared. Morphology of the scaffolds was characterized using atomic force microscopy (AFM). The hybrid nanofibrous mats were crosslinked using 25 % (v/v) glutaraldehyde vapor. In degradation study, the crosslinked nanofiber showed slow degradation of 20 % on weight after 35 days of incubation in simulated body fluid (SBF)...
December 2016: Journal of Membrane Biology
keyword
keyword
110354
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"