keyword
MENU ▼
Read by QxMD icon Read
search

electrospun nanofibrous scaffold

keyword
https://www.readbyqxmd.com/read/29649641/hydrogel-derived-from-porcine-decellularized-nerve-tissue-as-a-promising-biomaterial-for-repairing-peripheral-nerve-defects
#1
Tao Lin, Sheng Liu, Shihao Chen, Shuai Qiu, Zilong Rao, Jianghui Liu, Shuang Zhu, Liwei Yan, Haiquan Mao, Qingtang Zhu, Daping Quan, Xiaolin Liu
Decellularized matrix hydrogels derived from tissues or organs have been used for tissue repair due to their biocompatibility, tunability, and tissue-specific extracellular matrix (ECM) components. However, the preparation of decellularized peripheral nerve matrix hydrogels and their use to repair nerve defects have not been reported. Here, we developed a hydrogel from porcine decellularized nerve matrix (pDNM-G), which was confirmed to have minimal DNA content and retain collagen and glycosaminoglycans content, thereby allowing gelatinization...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29642582/synthesis-of-a-novel-electrospun-polycaprolactone-scaffold-functionalized-with-ibuprofen-for-periodontal-regeneration-an-in-vitro-andin-vivo-study
#2
Fareeha Batool, David-Nicolas Morand, Lionel Thomas, Isaac Maximiliano Bugueno, Javier Aragon, Silvia Irusta, Laetitia Keller, Nadia Benkirane-Jessel, Henri Tenenbaum, Olivier Huck
Ibuprofen (IBU) has been shown to improve periodontal treatment outcomes. The aim of this study was to develop a new anti-inflammatory scaffold by functionalizing an electrospun nanofibrous poly-ε-caprolactone membrane with IBU (IBU-PCL) and to evaluate its impact on periodontal inflammation, wound healing and regeneration in vitro and in vivo. IBU-PCL was synthesized through electrospinning. The effects of IBU-PCL on the proliferation and migration of epithelial cells (EC) and fibroblasts (FB) exposed to Porphyromonas gingivlais lipopolysaccharide (Pg -LPS) were evaluated through the AlamarBlue test and scratch assay, respectively...
April 10, 2018: Materials
https://www.readbyqxmd.com/read/29642421/nano-graphene-oxide-functionalized-bioactive-poly-lactic-acid-and-poly-%C3%AE%C2%B5-caprolactone-nanofibrous-scaffolds
#3
Duo Wu, Archana Samanta, Rajiv K Srivastava, Minna Hakkarainen
A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions...
April 6, 2018: Materials
https://www.readbyqxmd.com/read/29627682/electrically-polarized-plla-nanofibers-as-neural-tissue-engineering-scaffolds-with-improved-neuritogenesis
#4
Nathalie Barroca, Ana Marote, Sandra I Vieira, Abílio Almeida, Maria H V Fernandes, Paula M Vilarinho, Odete A B da Cruz E Silva
Tissue engineering is evolving towards the production of smart platforms exhibiting stimulatory cues to guide tissue regeneration. This work explores the benefits of electrical polarization to produce more efficient neural tissue engineering platforms. Poly (l-lactic) acid (PLLA)-based scaffolds were prepared as solvent cast films and electrospun aligned nanofibers, and electrically polarized by an in-lab built corona poling device. The characterization of the platforms by thermally stimulated depolarization currents reveals a polarization of 60 × 10-10 C cm-2 that is stable on poled electrospun nanofibers for up to 6 months...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29627465/electrospun-polyvinyl-alcohol-gelatin-chondroitin-sulfate-nanofibrous-scaffold-fabrication-and-in-vitro-evaluation
#5
Amin Sadeghi, Mohamad Pezeshki-Modaress, Mojgan Zandi
Electrospun nanofibers have attracted a lot of attention in recent years in tissue engineering applications. In this research, novel polyvinyl alcohol/gelatin/chondroitin sulfate (PVA/GE/Cs) nanofibrous scaffolds using non-carcinogen solvent system via electrospinning technique was evaluated. A solvent system containing water and acetic acid was used as a safe solvent system to obtain a homogenous mixture with suitable solvent properties and finally non-toxic nanofibrous scaffolds. The effect of water to the acetic acid ratio in the solvent system (7:3, 6:4, 5:5, 4:6, 3:7) and also polymer concentration (8, 9, 10 w/v %) on nanofibers morphology was investigated...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29611009/development-of-electrospun-chitosan-polyethylene-oxide-fibrinogen-biocomposite-for-potential-wound-healing-applications
#6
Tony T Yuan, Ann Marie DiGeorge Foushee, Monica C Johnson, Angela R Jockheck-Clark, Jonathan M Stahl
Normal wound healing is a highly complex process that requires the interplay of various growth factors and cell types. Despite advancements in biomaterials, only a few bioactive wound dressings reach the clinical setting. The purpose of this research was to explore the feasibility of electrospinning a novel nanofibrous chitosan (CS)-fibrinogen (Fb) scaffold capable of sustained release of platelet-derived growth factor (PDGF) for the promotion of fibroblast migration and wound healing. CS-Fb scaffolds were successfully electrospun using a dual-spinneret electrospinner and directly evaluated for their physical, chemical, and biological characteristics...
April 2, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29608489/enhanced-osteogenic-differentiation-of-mesenchymal-stem-cells-on-electrospun-pes-pva-prp-nanofibrous-scaffolds
#7
Mahshid Sadat Kashef-Saberi, Nasim Hayati Roodbari, Kazem Parivar, Saeid Vakilian, Hana Hanee-Ahvaz
Over the last few decades, great advancements have been achieved in the field of bone tissue engineering (BTE). Containing a great number of growth factors needed in the process of osteogenesis, platelet rich plasma (PRP) has gained a great deal of attention. However, due to the contradictory results achieved in different studies, its effectiveness remains a mystery. Therefore, in this study, we investigated in vitro performance of co-electrospun PRP/poly ether sulfone/poly(vinyl) alcohol (PRP/PES/PVA) composite scaffolds for the osteogenic differentiation of human adipose-derived mesenchymal stem cells...
March 28, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29588584/a-novel-electrospun-aligned-nanoyarn-three-dimensional-porous-nanofibrous-hybrid-scaffold-for-annulus-fibrosus-tissue-engineering
#8
Jun Ma, Yunfei He, Xilin Liu, Weiming Chen, An Wang, Chia-Ying Lin, Xiumei Mo, Xiaojian Ye
Introduction: Herniation of the nucleus pulposus (NP) because of defects in the annulus fibrosus (AF) is a well-known cause of low back pain. Defects in the AF thus remain a surgical challenge, and efforts have been made to develop new techniques for closure and repair. In this study, we developed an electrospun aligned nanoyarn scaffold (AYS) and nanoyarn/three-dimensional porous nanofibrous hybrid scaffold (HS) for AF tissue engineering. Methods: The AYS was fabricated via conjugated electrospinning, while the aligned nanofibrous scaffold (AFS) was prepared by traditional electrospinning as a baseline scaffold...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29577064/functionalization-of-pcl-3d-electrospun-nanofibrous-scaffolds-for-improved-bmp2-induced-bone-formation
#9
Jacob M Miszuk, Tao Xu, Qingqing Yao, Fang Fang, Josh D Childs, Zhongkui Hong, Jianning Tao, Hao Fong, Hongli Sun
Bone morphogenic protein 2 (BMP2) is a key growth factor for bone regeneration, possessing FDA approval for orthopedic applications. BMP2 is often required in supratherapeutic doses clinically, yielding adverse side effects and substantial treatment costs. Considering the crucial role of materials for BMPs delivery and cell osteogenic differentiation, we devote to engineering an innovative bone-matrix mimicking niche to improve low dose of BMP2-induced bone formation. Our previous work describes a novel technique, named thermally induced nanofiber self-agglomeration (TISA), for generating 3D electrospun nanofibrous (NF) polycaprolactone (PCL) scaffolds...
March 2018: Applied Materials Today
https://www.readbyqxmd.com/read/29551508/nanofibrous-silk-fibroin-reduced-graphene-oxide-scaffolds-for-tissue-engineering-and-cell-culture-applications
#10
Hande Nalvuran, Ayşe Eser Elçin, Yaşar Murat Elçin
Graphene and silk fibroin (SF) have been extensively investigated in the literature. Hybrid scaffolds of SF and graphene combine the properties of both of the materials and provide promising applications for tissue engineering purposes. In this study, reduced graphene oxide (RGO) (0.5%, 1.0% and 2.0% (w/v)) was incorporated into SF and fabricated into composite nanofibers through electrospinning. The fibers were characterized and analyzed by SEM, XRD, FTIR, TGA, circular dichroism analysis, contact angle measurements and tensile tests...
March 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29537390/incorporation-and-release-of-dual-growth-factors-for-nerve-tissue-engineering-using-nanofibrous-bicomponent-scaffolds
#11
Chaoyu Liu, Chong Wang, Qilong Zhao, Xiaohua Li, Feiyue Xu, Xumei Yao, Min Wang
Electrospun fibrous scaffolds have been extensively used as cell-supporting matrices or delivery vehicles for various biomolecules in tissue engineering. Biodegradable scaffolds with tunable degradation behaviors are favorable for various resorbable tissue replacements. In nerve tissue engineering, delivery of growth factors (GFs) such as nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) from scaffolds can be used to promote peripheral nerve repair. In this study, using the established dual-source dual-power (DS-DP) electrospinning technique, bicomponent scaffolds incorporated with NGF and GDNF were designed and demonstrated as a strategy to develop scaffolds providing dual GF delivery...
March 14, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29529861/3d-protein-based-bilayer-artificial-skin-for-guided-scarless-healing-of-3rd-degree-burn-wounds-in-vivo
#12
Mazaher Gholipourmalekabadi, Alexander M Seifalian, Aleksandra M Urbanska, Mir Davood Omrani, John G Hardy, Zahra Madjd, Seyed Mahmoud Hashemi, Hossein Ghanbarian, Peiman Brouki Milan, Masoud Mozafari, Rui L Reis, Subhas C Kundu, Ali Samadikuchaksaraei
Severe burn injuries can lead to delay in healing and devastating scar formation. Attempts are made to develop a suitable skin substitute for scarless healing of such skin wounds. Currently, there is no effective strategy yet for a complete scarless healing after the thermal injuries. In our recent work we fabricate and evaluated a 3D protein-based artificial skin made from decellularized human amniotic membrane (AM) and electrospun nanofibrous silk fibroin (ESF) in vitro. We also characterize both biophysical and cell culture investigation to establish in vitro performance of the developed bilayer scaffolds...
March 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29495264/engineering-of-corneal-tissue-through-an-aligned-pva-collagen-composite-nanofibrous-electrospun-scaffold
#13
Zhengjie Wu, Bin Kong, Rui Liu, Wei Sun, Shengli Mi
Corneal diseases are the main reason of vision loss globally. Constructing a corneal equivalent which has a similar strength and transparency with the native cornea, seems to be a feasible way to solve the shortage of donated cornea. Electrospun collagen scaffolds are often fabricated and used as a tissue-engineered cornea, but the main drawback of poor mechanical properties make it unable to meet the requirement for surgery suture, which limits its clinical applications to a large extent. Aligned polyvinyl acetate (PVA)/collagen (PVA-COL) scaffolds were electrospun by mixing collagen and PVA to reinforce the mechanical strength of the collagen electrospun scaffold...
February 24, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29482061/surface-modification-of-nanofibrous-matrices-via-layer-by-layer-functionalized-silk-assembly-for-mitigating-the-foreign-body-reaction
#14
Yuna Qian, Linhao Li, Yang Song, Lili Dong, Peixing Chen, Xiaoming Li, Kaiyong Cai, Oliver Germershaus, Li Yang, Yubo Fan
The inherent hydrophobicity and large surface area of electrospun synthetic polymeric scaffolds often cause non-specific protein adsorption, thereby influencing macrophage functions and eventually leading to fibrosis at the tissue-scaffold interface. This work reports fabrication of silk fibroin (SF)-functionalized electrospun polycaprolactone (PCL) fibers by single-component layer-by-layer assembly and decorate the SF with heparin disaccharide (HD), resulting in the non-covalent binding of interleukin-4 (IL-4) with the capacity to modulate macrophage polarization...
February 20, 2018: Biomaterials
https://www.readbyqxmd.com/read/29467436/fabrication-of-transparent-hemispherical-3d-nanofibrous-scaffolds-with-radially-aligned-patterns-via-a-novel-electrospinning-method
#15
Jeong In Kim, Ju Yeon Kim, Chan Hee Park
Tissue engineering has significantly contributed to the development of optimal treatments for individual injury sites based on their unique functional and histologic properties. Human organs and tissue have three-dimensional (3D) morphologies; for example, the morphology of the eye is a spherical shape. However, most conventional electrospinning equipment is only capable of fabricating a two-dimensional (2D) structured fibrous scaffold and no report is available on a 3D electrospinning method to fabricate a hemispherical scaffold to mimic the native properties of the cornea, including microscopic to macroscopic morphology and transparency...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463042/promotion-of-vascular-morphogenesis-of-endothelial-cells-co-cultured-with-human-adipose-derived-mesenchymal-stem-cells-using-polycaprolactone-gelatin-nanofibrous-scaffolds
#16
Yun-Min Kook, Hyerim Kim, Sujin Kim, Chan Yeong Heo, Min Hee Park, Kangwon Lee, Won-Gun Koh
New blood vessel formation is essential for tissue regeneration to deliver oxygen and nutrients and to maintain tissue metabolism. In the field of tissue engineering, in vitro fabrication of new artificial vessels has been a longstanding challenge. Here we developed a technique to reconstruct a microvascular system using a polycaprolactone (PCL)/gelatin nanofibrous structure and a co-culture system. Using a simple electrospinning process, we fabricated three-dimensional mesh scaffolds to support the sprouting of human umbilical vein endothelial cells (HUVECs) along the electrospun nanofiber...
February 18, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29454157/nanofibrous-plga-electrospun-scaffolds-modified-with-type-i-collagen-influence-hepatocyte-function-and-support-viability-in-vitro
#17
Jessica H Brown, Prativa Das, Michael D DiVito, David Ivancic, Lay Poh Tan, Jason A Wertheim
A major challenge of maintaining primary hepatocytes in vitro is progressive loss of hepatocyte-specific functions, such as protein synthesis and cytochrome P450 (CYP450) catalytic activity. We developed a three-dimensional (3D) nanofibrous scaffold made from poly(L-lactide-co-glycolide) (PLGA) polymer using a newlyoptimizedwet electrospinning techniquethat resulted in a highly porous structure that accommodated inclusion of primary human hepatocytes. Extracellular matrix (ECM) proteins (type I collagen or fibronectin) at varying concentrations were chemically linked to electrospun PLGA using amine coupling to develop an in vitro culture system containing the minimal essential ECM components of the liver micro-environment that preserve hepatocyte function in vitro...
February 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29453143/structure-and-physico-mechanical-properties-of-low-temperature-plasma-treated-electrospun-nanofibrous-scaffolds-examined-with-atomic-force-microscopy
#18
Adrian Chlanda, Ewa Kijeńska, Chiara Rinoldi, Michał Tarnowski, Tadeusz Wierzchoń, Wojciech Swieszkowski
Electrospun nanofibrous scaffolds are willingly used in tissue engineering applications due to their tunable mechanical, chemical and physical properties. Additionally, their complex openworked architecture is similar to the native extracellular matrix of living tissue. After implantation such scaffolds should provide sufficient mechanical support for cells. Moreover, it is of crucial importance to ensure sterility and hydrophilicity of the scaffold. For this purpose, a low temperature surface plasma treatment can be applied...
February 8, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29405909/developing-improved-tissue-engineered-buccal-mucosa-grafts-for-urethral-reconstruction
#19
A Simsek, A J Bullock, S Roman, C R Chapple, S Macneil
INTRODUCTION: We aimed to compare alternative synthetic scaffolds suitable for future implantation and to examine the use of an inhibitor of lysyl oxidase (beta-amino- propionitrile [β-APN]) to reduce contraction in these implants. METHODS: Three synthetic scaffolds were compared to natural dermis as substrates for the production of tissue-engineered skin. For natural dermis, Euroskin was used to provide a cell-free cadaveric dermis. Synthetic scaffolds consisted of microfibrous PLA, nanofibrous PHBV, and a micro-/nanofibrous trilayer of PLA-PHBV-PLA...
February 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29356571/a-biomimetic-emu-oil-blended-electrospun-nanofibrous-mat-for-maintaining-stemness-of-adipose-tissue-derived-stem-cells
#20
Sepideh Jalilzadeh-Tabrizi, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Shahriar Alipour, Mehdi Dadashpour, Kazem Nejati-Koshki, Nosratollah Zarghami
BACKGROUND: Emu oil (EO) with anti-inflammatory, antioxidative, and wound healing properties can be blended for preparing bioactive nanofibrous scaffold. Adipose tissue-derived stem cells (ADSCs) are promising candidates for tissue engineering, and preserving their stemness potential is vital for further therapeutic applications. AIM: The aim of this study was to fabricate EO-blended nanofiber and investigate its effect on proliferation, survival, and stemness preservation of ADSCs...
April 2018: Biopreservation and Biobanking
keyword
keyword
110354
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"