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electrospun scaffold for meniscal repair

Benjamin B Rothrauff, Piya-On Numpaisal, Brian B Lauro, Peter G Alexander, Richard E Debski, Volker Musahl, Rocky S Tuan
BACKGROUND: Large radial tears that disrupt the circumferential fibers of the meniscus are associated with reduced meniscal function and increased risk of joint degeneration. Electrospun fibrous scaffolds can mimic the topography and mechanics of fibrocartilaginous tissues and simultaneously serve as carriers of cells and growth factors, yet their incorporation into clinically relevant suture repair techniques for radial meniscus tears is unexplored. The purposes of this study were to (1) evaluate the effect of fiber orientation on the tensile properties and suture-retention strength of multilayered electrospun scaffolds and (2) determine the mechanical effects of scaffold inclusion within a surgical repair of a simulated radial meniscal tear...
December 2016: Journal of Experimental Orthopaedics
Jihye Baek, Sujata Sovani, Nicholas E Glembotski, Jiang Du, Sungho Jin, Shawn P Grogan, Darryl D D'Lima
The self-healing capacity of an injured meniscus is limited to the vascularized regions and is especially challenging in the inner avascular regions. As such, we investigated the use of human meniscus cell-seeded electrospun (ES) collagen type I scaffolds to produce meniscal tissue and explored whether these cell-seeded scaffolds can be implanted to repair defects created in meniscal avascular tissue explants. Human meniscal cells (derived from vascular and avascular meniscal tissue) were seeded on ES scaffolds and cultured...
March 2016: Tissue Engineering. Part A
John T Martin, Andrew H Milby, Kensuke Ikuta, Subash Poudel, Christian G Pfeifer, Dawn M Elliott, Harvey E Smith, Robert L Mauck
UNLABELLED: Tissue engineering strategies have emerged in response to the growing prevalence of chronic musculoskeletal conditions, with many of these regenerative methods currently being evaluated in translational animal models. Engineered replacements for fibrous tissues such as the meniscus, annulus fibrosus, tendons, and ligaments are subjected to challenging physiologic loads, and are difficult to track in vivo using standard techniques. The diagnosis and treatment of musculoskeletal conditions depends heavily on radiographic assessment, and a number of currently available implants utilize radiopaque markers to facilitate in vivo imaging...
October 2015: Acta Biomaterialia
Kazunori Shimomura, Allison C Bean, Hang Lin, Norimasa Nakamura, Rocky S Tuan
Radial tears of the meniscus represent one of the most common injuries of the knee, and result in loss of biomechanical meniscal function. However, there have been no established, effective treatments for radial meniscal tears. Nanofibrous materials produced by electrospinning have shown high promise in the engineering of soft musculoskeletal tissues. The goal of our study is to apply these technologies to develop a functional cell-seeded scaffold as a potential, new surgical method to enhance meniscal radial repair...
July 2015: Tissue Engineering. Part A
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