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https://www.readbyqxmd.com/read/30419274/electrostatically-mediated-protein-protein-interactions-for-monoclonal-antibodies-a-combined-experimental-and-coarse-grained-molecular-modeling-approach
#1
Glenn M Ferreira, Cesar Calero-Rubio, Sathish Hasige, Richard L Remmele, Christopher J Roberts
Electrostatically mediated protein-protein interactions (PPI) can influence key product properties such as solubility, solution viscosity, and aggregation rates. Predictive models would allow for candidates / formulations to be screened with little or no protein material. Three monoclonal antibodies (MAbs) that display qualitatively different experimental PPI were evaluated at a range of pH and ionic strength conditions that are typical of product formulations. PPI parameters (kD , B22 , and G22 ) were obtained from static and dynamic light scattering measurements, and spanned from strongly repulsive to strongly attractive net interactions...
November 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30418613/exploring-the-effects-of-cosolutes-and-crowding-on-the-volumetric-and-kinetic-profile-of-the-conformational-dynamics-of-a-poly-da-loop-dna-hairpin-a-single-molecule-fret-study
#2
Satyajit Patra, Vitor Schuabb, Irena Kiesel, Jim-Marcel Knop, Rosario Oliva, Roland Winter
We investigated the volumetric and kinetic profile of the conformational landscape of a poly dA loop DNA hairpin (Hp) in the presence of salts, osmolytes and crowding media, mimicking the intracellular milieu, using single-molecule FRET methodology. Pressure modulation was applied to explore the volumetric and hydrational characteristics of the free-energy landscape of the DNA Hp, but also because pressure is a stress factor many organisms have to cope with, e.g. in the deep sea where pressures even up to the kbar level are encountered...
November 12, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30418328/normative-reference-values-for-high-school-aged-american-football-players-proagility-drill-and-40-yard-dash-split-times
#3
Brianna D McKay, Amelia A Miramonti, Zachary M Gillen, Todd J Leutzinger, Alegra I Mendez, Nathaniel D M Jenkins, Joel T Cramer
McKay, BD, Miramonti, AA, Gillen, ZM, Leutzinger, TJ, Mendez, AI, Jenkins, NDM, and Cramer, JT. Normative reference values for high school-aged American football players: Proagility drill and 40-yard dash split times. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this short report was to provide test- and position-specific normative reference values for the 10- and 20-yd split times (10YD and 20YD) during the 40-yd dash (40YD) as well as 10-yd split times during the proagility drill (PA) based on a large, nationally representative sample of high school-aged American football players in their freshman, sophomore, and junior classes...
November 8, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/30417967/fabrication-and-characterization-of-recombinant-silk-elastin-like-protein-selp-fiber
#4
Erin G Roberts, Nae-Gyune Rim, Wenwen Huang, Anna Tarakanova, Jingjie Yeo, Markus J Buehler, David L Kaplan, Joyce Y Wong
Silk-elastin-like-protein polymers (SELPs) are genetically engineered recombinant protein sequences consisting of repeating units of silk-like and elastin-like blocks. By combining these entities, it is shown that both the characteristic strength of silk and the temperature-dependent responsiveness of elastin can be leveraged to create an enhanced stimuli-responsive material. It is hypothesized that SELP behavior can be influenced by varying the silk-to-elastin ratio. If the responsiveness of the material at different ratios is significantly different, this would allow for the design of materials with specific temperature-based swelling and mechanical properties...
November 12, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/30417895/edta-conditioning-increases-the-long-term-microtensile-bond-strength-to-sclerotic-dentin-mediated-by-self-etch-adhesives
#5
Issis Virginia Luque-Martinez, Miguel Angel Muñoz, Viviane Hass, Elisama Sutil, Alessandra Reis, Alessandro D Loguercio
PURPOSE: To evaluate the immediate and 12-month microtensile bond strength (μTBS) of two self-etch adhesives on sclerotic dentin with or without previous EDTA conditioning. The conditioning pattern and the relative area of open dentinal tubules were also evaluated. MATERIALS AND METHODS: Twenty-eight bovine incisors with naturally exposed sclerotic dentin were used. For μTBS testing, 20 teeth were divided into 4 groups (n = 5) according to the combination of the main factors: 1...
2018: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/30417806/a-meta-analysis-of-low-intensity-cognitive-behavioral-therapy-based-interventions-for-dementia-caregivers
#6
Laura Kaddour, Naoko Kishita, Anthony Schaller
ABSTRACTObjectives:This study aimed to review the effectiveness of low-intensity cognitive behavioral therapy (CBT)-based interventions for informal dementia caregivers when compared to non-active control conditions. DESIGN: Literature searches were conducted in databases of published (PsycINFO, MEDLINE, CINAHL, Scopus) and unpublished (Open Grey, ISRCTN registry, ClinicalTrials.gov, ProQuest) literature. Individual meta-analyses were conducted for each outcome variable. Pooled intervention effect estimates were calculated as Hedge's g using a random-effects model...
November 12, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/30417718/cognitive-motor-interference-in-persons-with-multiple-sclerosis-during-five-upper-limb-motor-tasks-with-different-complexity
#7
Joke Raats, Ilse Lamers, Ilse Baert, Barbara Willekens, Renee Veldkamp, Peter Feys
BACKGROUND: Cognitive-motor interference in multiple sclerosis has been well examined during walking, but not during upper limb (UL) performance. OBJECTIVES: To examine the dual-task cost (DTC) in persons with multiple sclerosis (pwMS) and healthy controls (HC) in various type and complexity of UL motor tasks. METHOD: In total, 30 pwMS without major UL impairment and 30 HC performed five different UL tasks, in single condition and combined with the phonemic word list generation task...
November 12, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30417644/toward-understanding-of-self-electrophoretic-propulsion-under-realistic-conditions-from-bulk-reactions-to-confinement-effects
#8
Michael Kuron, Patrick Kreissl, Christian Holm
Active matter concerns itself with the study of particles that convert energy into work, typically motion of the particle itself. This field saw a surge of interest over the past decade, after the first micrometer-sized, man-made chemical motors were created. These particles served as a simple model system for studying in a well-controlled manner complex motion and cooperative behavior as known from biology. In addition, they have stimulated new efforts in understanding out-of-equilibrium statistical physics and started a revolution in microtechnology and robotics...
November 12, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30417319/enzymatic-activity-of-urokinase-immobilized-onto-cu-2-chelated-cibacron-blue-f3ga-derived-poly-hema-magnetic-nanoparticles
#9
Sinem Evli, Deniz Aktaş Uygun
In this presented work, magnetic poly(2-hydroxyethyl methacrylate) (p (HEMA)) nanoparticles were synthesized by surfactant-free emulsion polymerization technique. Cibacron Blue F3GA was covalently attached to the magnetic p (HEMA) nanoparticles and Cu2+ ions were then chelated with dye molecules. Synthesized magnetic nanoparticles were spherical with the diameter of 80 nm and exhibited magnetic character. Incorporation rate of Cibacron Blue for magnetic nanoparticles was found to be 28.125-μmol/g polymer...
November 12, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/30415644/sport-doping-and-male-fertility
#10
REVIEW
Andrea Sansone, Massimiliano Sansone, Diana Vaamonde, Paolo Sgrò, Ciro Salzano, Francesco Romanelli, Andrea Lenzi, Luigi Di Luigi
It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nutrition and sedentary behavior, is suggested in order to preserve/improve fertility in humans. However, the possible risks of physical exercise per se or sports on male fertility are less known. Being "fit" does not only improve the sense of well-being, but also has beneficial effects on general health: in fact physical exercise is by all means a low-cost, high-efficacy method for preventing or treating several conditions, ranging from purely physical (diabetes and obesity) to psychological (depression and anxiety), highly influencing male reproduction...
November 12, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30412883/extraction-of-pahs-from-an-aged-creosote-polluted-soil-by-cyclodextrins-and-rhamnolipids-side-effects-on-removal-and-availability-of-potentially-toxic-elements
#11
Fernando Madrid, Rubén Ballesteros, Silvia Lacorte, Jaime Villaverde, Esmeralda Morillo
This study evaluated the effect of several cyclodextrins (CDs) and a rhamnolipid (RL) on the removal of polycyclic aromatic hydrocarbons (PAHs) from a co-contaminated soil which had received historically creosote and inorganic wood preservatives for almost 100 years, and the effect of such extractions on the potentially toxic elements (PTEs). The influence on such processes of an electrolyte (0.01 M Ca(NO3 )2 ) was also studied. Up to 15.4% of the ∑16 PAHs were extracted using RL in the absence of the electrolyte as washing solution, but decreases until reaching 0...
October 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30412004/validity-of-judo-specific-tests-to-assess-neuromuscular-performance-of-judo-athletes
#12
Rafael Lima Kons, Jorge Nelson Da Silva Junior, Bruno Follmer, Luiz Felipe Guarise Katcipis, Ramdane Almansba, Daniele Detanico
Uchi-komi Fitness Test (UFT) is a specific judo test that evaluates physiological fitness of judo athletes in similar conditions to judo matches. Neuromuscular parameters obtained by generic and judo-specific tests would aid to get more information about its criterion validity. This study aimed to analyse the relationship between UFT and shoulder external (PTEX ) and internal (PTINT ) rotation torque, handgrip strength (HGS) and vertical jumps (VJs) performance. The relationship between UFT and Judogi grip strength test (JGST) was also investigated...
November 9, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/30411740/effects-of-calcium-on-the-kinetics-of-a-model-disjunctive-ligand-exchange-reaction-implications-for-dynamic-trace-metal-ion-speciation
#13
Laura T Rea, Yi Xu, Nathan E Boland
Trace metal ion speciation in natural waters is often under kinetic control due to slow exchange reactions involving multidentate ligands (both natural and anthropogenic) and constituent ions (e.g. calcium). Incomplete understanding of the kinetic behavior (rates, rate laws, and mechanisms) of multidentate ligand exchange reactions hinders prediction of metal ion bioavailability and mobility in these systems. Here, we aim to improve understanding (1) by examining the mechanism by which calcium suppresses ligand exchange rates and (2) by developing conceptual tools for predicting the kinetic behavior in environmental systems...
November 9, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/30411599/effects-of-sexual-activity-on-several-measures-of-physical-performance-in-young-adult-males
#14
Gerald S Zavorsky, Wendy L Newton
BACKGROUND: There has been considerable debate as to whether sexual activity prior to an athletic event can affect physical performance. The goal of the study was to determine if sexual activity the evening before several physical performance tests affected the results compared to the same performance tests after five days of abstinence. METHODS: Ten, monogamous, married young men (28 ± 7 years old, body mass index = 25.5 ± 2.7 kg/m2) underwent a six-physical performance / balance /agility tests (forearm grip strength, balance, lateral movement, reaction time, anaerobic power, and maximal oxygen uptake) on three different days...
October 31, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/30410980/direct-observation-of-the-interplay-of-catechol-binding-and-polymer-hydrophobicity-in-a-mussel-inspired-elastomeric-adhesive
#15
Sukhmanjot Kaur, Amal Narayanan, Siddhesh Dalvi, Qianhui Liu, Abraham Joy, Ali Dhinojwala
Marine organisms such as mussels have mastered the challenges in underwater adhesion by incorporating post-translationally modified amino acids like l-3,4-dihydroxyphenylalanine (DOPA) in adhesive proteins. Here we designed a catechol containing elastomer adhesive to identify the role of catechol in interfacial adhesion in both dry and wet conditions. To decouple the adhesive contribution of catechol to the overall adhesion, the elastomer was designed to be cross-linked through [2 + 2] photo-cycloaddition of coumarin...
October 24, 2018: ACS Central Science
https://www.readbyqxmd.com/read/30410769/the-influence-of-kinesiology-tape-colour-on-performance-and-corticomotor-activity-in-healthy-adults-a-randomised-crossover-controlled-trial
#16
Rocco Cavaleri, Tribikram Thapa, Paula R Beckenkamp, Lucy S Chipchase
Background: There exists conflicting evidence regarding the impact of kinesiology tape on performance and muscle function. One variable that may account for disparities in the findings of previous studies is the colour of the tape applied. Colour is hypothesised to influence sporting performance through modulation of arousal and aggression. However, few studies have investigated the influence of colour on products designed specifically to enhance athletic performance. Further, no studies have investigated the potential influence of colour on other drivers of performance, such as corticomotor activity and neuromuscular function...
2018: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/30410318/elevated-serum-il-6-and-adiponectin-levels-are-associated-with-frailty-and-physical-function-in-chinese-older-adults
#17
Lina Ma, Guiming Sha, Yaxin Zhang, Yun Li
Purpose: Frailty is associated with adverse health outcomes. Its biological markers are essential to enhance diagnostic ease and would contribute to surveillance of the condition. Considering the involvement of pro-inflammatory and nutritional states in frailty, we aimed to investigate whether inflammatory mediators and adipokines are associated with frailty and their relationship with physical function. Patients and methods: We recruited 130 older adults (90 nonfrail participants and 40 frail participants, mean age: 72...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/30410311/patients-physicians-nurses-and-pharmacists-preferences-on-the-characteristics-of-biologic-agents-used-in-the-treatment-of-rheumatic-diseases
#18
Luciana Scalone, Piercarlo Sarzi-Puttini, Luigi Sinigaglia, Carlomaurizio Montecucco, Roberto Giacomelli, Giovanni Lapadula, Ignazio Olivieri, Angela Maria Giardino, Paolo Angelo Cortesi, Lorenzo Giovanni Mantovani, Monica Mecchia
Objective: To estimate preferences in relevant treatment characteristics evaluated by different groups involved in the management of patients with rheumatic diseases. Subjects and methods: We surveyed patients with rheumatic diseases, and rheumatologists, nurses, and pharmacists with experience in treatment with/provision of biologic drugs for these patients. Through a discrete choice experiment, participants evaluated 16 possible scenarios in which pairs of similarly efficacious treatments were described with six characteristics: 1) frequency of administration; 2) mode and place of administration; 3) manner, helpfulness, efficiency, and courtesy of health personnel; 4) frequency of reactions at the site of drug administration; 5) severity of generalized undesired/allergic reactions; and 6) additional cost...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/30409915/comparative-effectiveness-and-harms-of-intravitreal-antivascular-endothelial-growth-factor-agents-for-three-retinal-conditions-a-systematic-review-and-meta-analysis
#19
Allison Low, Ambar Faridi, Kavita V Bhavsar, Glenn C Cockerham, Michele Freeman, Rochelle Fu, Robin Paynter, Karli Kondo, Devan Kansagara
Intravitreal antivascular endothelial growth factor (VEGF) agents are widely used to treat ocular conditions but the benefits and harms of these treatments are uncertain. We conducted a systematic review to compare the effects of aflibercept, bevacizumab and ranibizumab on best-corrected visual acuity (BCVA) changes, quality of life and ocular or systemic adverse events in patients with neovascular age-related macular degeneration (NVAMD), diabetic macular oedema (DME) and central or branch retinal vein occlusion (RVO)...
November 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/30409492/depression-is-associated-with-sarcopenia-due-to-low-muscle-strength-results-from-the-elsa-brasil-study
#20
Claudia Szlejf, Claudia K Suemoto, Andre R Brunoni, Maria Carmen Viana, Arlinda B Moreno, Sheila M A Matos, Paulo A Lotufo, Isabela M Benseñor
OBJECTIVES: To investigate the association of sarcopenia and its defining components with depression in Brazilian middle-aged and older adults. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: This analysis included 5927 participants from the ELSA-Brasil Study second data collection, aged 55 years and older, with complete data for exposure, outcome, and covariates. MEASURES: Muscle mass was evaluated by bioelectrical impedance analysis and muscle strength by hand-grip strength...
November 5, 2018: Journal of the American Medical Directors Association
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