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https://www.readbyqxmd.com/read/30235212/modulation-of-acd6-dependent-hyperimmunity-by-natural-alleles-of-an-arabidopsis-thaliana-nlr-resistance-gene
#1
Wangsheng Zhu, Maricris Zaidem, Anna-Lena Van de Weyer, Rafal M Gutaker, Eunyoung Chae, Sang-Tae Kim, Felix Bemm, Lei Li, Marco Todesco, Rebecca Schwab, Frederik Unger, Marcel Janis Beha, Monika Demar, Detlef Weigel
Plants defend themselves against pathogens by activating an array of immune responses. Unfortunately, immunity programs may also cause unintended collateral damage to the plant itself. The quantitative disease resistance gene ACCELERATED CELL DEATH 6 (ACD6) serves to balance growth and pathogen resistance in natural populations of Arabidopsis thaliana. An autoimmune allele, ACD6-Est, which strongly reduces growth under specific laboratory conditions, is found in over 10% of wild strains. There is, however, extensive variation in the strength of the autoimmune phenotype expressed by strains with an ACD6-Est allele, indicative of genetic modifiers...
September 20, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/30234613/allergy-alert-test-for-p-phenylenediamine-allergic-hair-dye-users
#2
Pieter-Jan Coenraads, Werner Aberer, Antonio Cristaudo, Thomas Diepgen, Catherine Holden, Lukas Koch, Marie-Louise Schuttelaar, Elke Weisshaar, Anne Fuchs, Kordula Schlotmann, Carsten Goebel, Brunhilde Blömeke, Maya Krasteva
BACKGROUND: Contact dermatitis to hair dyes remains a health concern. Regulations in many countries require consumer self-testing for hair dyes, but no standardized procedure exists. OBJECTIVE: The aim of this study was to develop a self-test protocol for an allergy alert test (AAT) that can elicit a self-noticeable alert signal in p-phenylenediamine (PPD)-allergic consumers. METHODS: Simulating consumer use conditions (open application for 45 minutes after mixing with a developer), PPD-positive hair dye-allergic subjects and PPD-negative control subjects were tested on the forearm and behind the ear with experimental products containing 0...
September 2018: Dermatitis
https://www.readbyqxmd.com/read/30233960/treatment-of-hip-flexion-contractures-with-psoas-recession-through-the-middle-window-of-the-ilioinguinal-approach
#3
Daniel J Gittings, Jonathan R Dattilo, George Fryhofer, Derek J Donegan, Keith Baldwin
Introduction: The ilioinguinal approach for psoas recession over the pelvic brim allows for direct visualization and protection of the femoral nerve while preserving hip flexion strength. Indications & Contraindications: <AbstractText Label="Step 1 Patient Positioning Preoperative Assessment and Draping" NlmCategory="UNASSIGNED">With the patient supine and anesthetized, perform the Thomas test, administer antibiotics, and drape to provide access to the inferior aspect of the abdomen, ilioinguinal region, and lower limb...
September 28, 2017: JBJS Essential Surgical Techniques
https://www.readbyqxmd.com/read/30233421/subregions-of-the-anterior-cingulate-cortex-form-distinct-functional-connectivity-patterns-in-young-males-with-internet-gaming-disorder-with-comorbid-depression
#4
Deokjong Lee, Junghan Lee, Kee Namkoong, Young-Chul Jung
Depression is one of the most common comorbid conditions in Internet Gaming Disorder (IGD). Although there have been many studies on the pathophysiology of IGD, the neurobiological basis underlying the close association between depression and IGD has not been fully clarified. Previous neuroimaging studies have demonstrated functional and structural abnormalities in the anterior cingulate cortex (ACC) in IGD patients. In this study, we explored functional connectivity (FC) abnormalities involving subregions of the ACC in IGD subjects with comorbid depression...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30233259/utility-of-fms-to-understand-injury-incidence-in-sports-current-perspectives
#5
REVIEW
Meghan Warren, Monica R Lininger, Nicole J Chimera, Craig A Smith
The Functional Movement Screen (FMS) is a popular movement screen used by rehabilitation, as well as strength and conditioning, professionals. The FMS, like other movement screens, identifies movement dysfunction in those at risk of, but not currently experiencing, signs or symptoms of a musculoskeletal injury. Seven movement patterns comprise the FMS, which was designed to screen fundamental movement requiring a balance between stability and mobility. The 7 movement patterns are summed to a composite FMS score...
2018: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/30232790/sex-specific-changes-in-physical-performance-following-military-training-a-systematic-review
#6
REVIEW
Jo Varley-Campbell, Chris Cooper, Daryl Wilkerson, Sophie Wardle, Julie Greeves, Theo Lorenc
INTRODUCTION: Men and women joining the military undergo the same training, often in mixed-sex platoons. Given the inherent physiological and physical performance differences between men and women, it is reasonable to question whether sex differences exist in the adaptation to military training and, therefore, whether sex-specific training should be employed to optimise training adaptations. OBJECTIVE: To systematically review the literature evaluating changes in the physical performance of men and women following military training...
September 19, 2018: Sports Medicine
https://www.readbyqxmd.com/read/30232586/micro-finite-element-analysis-of-the-proximal-femur-on-the-basis-of-high-resolution-magnetic-resonance-images
#7
REVIEW
Chamith S Rajapakse, Gregory Chang
PURPOSE OF REVIEW: Hip fractures have catastrophic consequences. The purpose of this article is to review recent developments in high-resolution magnetic resonance imaging (MRI)-guided finite element analysis (FEA) of the hip as a means to determine subject-specific bone strength. RECENT FINDINGS: Despite the ability of DXA to predict hip fracture, the majority of fractures occur in patients who do not have BMD T scores less than - 2.5. Therefore, without other detection methods, these individuals go undetected and untreated...
September 19, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/30232265/phosphoethanolamine-cellulose-enhances-curli-mediated-adhesion-of-uropathogenic-escherichia-coli-to-bladder-epithelial-cells
#8
Emily C Hollenbeck, Alexandra Antonoplis, Chew Chai, Wiriya Thongsomboon, Gerald G Fuller, Lynette Cegelski
Uropathogenic Escherichia coli (UPEC) are the major causative agents of urinary tract infections, employing numerous molecular strategies to contribute to adhesion, colonization, and persistence in the bladder niche. Identifying strategies to prevent adhesion and colonization is a promising approach to inhibit bacterial pathogenesis and to help preserve the efficacy of available antibiotics. This approach requires an improved understanding of the molecular determinants of adhesion to the bladder urothelium...
September 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30231886/society-for-cardiovascular-magnetic-resonance-scmr-expert-consensus-for-cmr-imaging-endpoints-in-clinical-research-part-i-analytical-validation-and-clinical-qualification
#9
REVIEW
Valentina O Puntmann, Silvia Valbuena, Rocio Hinojar, Steffen E Petersen, John P Greenwood, Christopher M Kramer, Raymond Y Kwong, Gerry P McCann, Colin Berry, Eike Nagel
Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more chronic and indolent course. These include an increased deployment of safe screening methods, life-long surveillance, and monitoring of both disease activity and tailored-treatment, by way of increasingly personalized medical care. Cardiovascular magnetic resonance (CMR) is a non-invasive, ionising radiation-free method, which can support a significant number of clinically relevant measurements and offers new opportunities to advance the state of art of diagnosis, prognosis and treatment...
September 20, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/30231053/strength-microstructure-and-thermal-conductivity-of-the-insulation-wallboards-prepared-with-rice-husk-fiber-and-recycled-concrete-aggregates
#10
Xiaoniu Yu, Linzhu Sun
This paper intends to evaluate the influence of content of rice husk fiber and cementitious materials on mechanical properties and thermal conductivity of thermal insulation wallboards. Thermal insulation wallboard contained different mass of rice husk fiber was prepared when the weight of cement, fly ash, cellulose ether, naphthalene superplasticizer, and recycled concrete aggregates was equal. Scanning electron microscopy (SEM) shows the internal structure of the insulation wallboards is very dense. Compared to thermal conductivity of blank group (0...
2018: PloS One
https://www.readbyqxmd.com/read/30230685/antibacterial-3d-bone-scaffolds-for-tissue-engineering-application
#11
Jitendra Pant, Jaya Sundaram, Marcus J Goudie, Dieu Thao Nguyen, Hitesh Handa
Open bone fractures are not only difficult to heal but also are at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. Endogenously released nitric oxide (NO) has been shown to play a role in osteogenic differentiation in addition to eradicating infection against a wide variety of pathogens. In the current work, antimicrobial NO releasing 3D bone scaffolds were fabricated using S-nitroso-N-acetyl-penicillamine (SNAP) as the NO donor. During fabrication, nano-hydroxyapatite (nHA) was added to each of the scaffolds in the concentration range of 10-50 wt % in nHA-starch-alginate and nHA-starch-chitosan scaffolds...
September 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30230641/high-dose-vitamin-d-without-benefit-but-not-without-risk
#12
Ian R Reid
It is now 100 years since deficiency of vitamin D was identified as the cause of rickets and osteomalacia (see Figure). Since then, enormous amounts of work have been undertaken elucidating the synthesis and catabolism of vitamin D, the regulation of these processes, and the mechanisms of action of vitamin D metabolites on calcium and bone metabolism. The findings of the early studies, mainly in children, that vitamin D promotes the growth and mineralisation of the skeleton have been generalised to other contexts, and vitamin D has become widely used in many conditions associated with decreases in skeletal strength, particularly in the prevention and treatment of osteoporosis...
September 19, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/30229667/the-effectiveness-of-backward-walking-as-a-treatment-for-people-with-gait-impairments-a-systematic-review-and-meta-analysis
#13
Tharani Balasukumaran, Benita Olivier, Mokgobadibe Veronica Ntsiea
OBJECTIVE: To investigate the effectiveness of backward walking in the treatment of people with gait impairments related to neurological and musculoskeletal disorders. DESIGN: Systematic review and meta-analysis of randomized and quasi-randomized control studies. DATA SOURCES: Searched from the date of inception to March 2018, and included PubMed, Scopus, Cochrane Library, PEDro, CINAHL, and the MEDLINE databases. METHODS: Investigating the effects of backward walking on pain, functional disability, muscle strength, gait parameters, balance, stability, and plantar pressure in people with gait impairments...
September 19, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/30229630/-isolation-identification-and-degradation-characteristics-of-a-17-%C3%AE-estradiol-degrading-strain-fusarium-sp-ky123915
#14
Man-Li Wu, Chang-Cheng Zhu, Yan-Yun Qi, Yi-Xin Shi, Hui-Ning Xu, Jin-Ru Yang
A 17 β -estradiol (E2) degrading strain (designated as Wu-SP1) was isolated from the activated sludge collected from a wastewater treatment plant (WWTP) in Xi'an. The strain was identified as Fusarium sp. according to 18S rDNA sequence and phylogenetic analysis. The optimal pH and temperature for E2 degradation were 6 and 30℃, respectively. Under these conditions, the E2 biodegradation rate of 2 mg·L-1 E2 amounted to 92.5% within 48 h by this strain. The kinetics of E2 degradation by the strain KY123915 were in good accord with the first-order equation, with the concentration ranged from 10 to 500 mg·L-1 ...
October 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
https://www.readbyqxmd.com/read/30229498/novel-preclinical-murine-model-of-trauma-induced-elbow-stiffness
#15
Stephanie N Moore-Lotridge, William K Oelsner, Yael Ihejirika, Mihir J Desai, Sandra S Gebhart, Jonathan G Schoenecker
BACKGROUND: Peri-articular injury may result in functional deficits and pain. In particular, post-traumatic elbow stiffness is a debilitating condition, precluding patients from performing activities of daily living. As such, clinicians and basic scientists alike, aim to develop novel therapeutic interventions to prevent and treat elbow stiffness; thereby reducing patient morbidity. Yet, there is a paucity of pre-clinical models of peri-articular stiffness, especially of the upper extremity, necessary to develop and test the efficacy of therapeutics...
September 18, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/30228009/magnetic-solid-phase-extraction-of-sulfonamides-based-on-carboxylated-magnetic-graphene-oxide-nanoparticles-in-environmental-waters
#16
P-Shiqian Gao, Yutong Guo, Xinyue Li, Xuedong Wang, Junxia Wang, Feiyue Qian, Haidong Gu, Zhanen Zhang
A magnetic nano-adsorbent material was prepared by functionalizing carboxylic group onto the granule surface of magnetic graphene oxide nanoparticles (CMGO), using in-situ co-precipitating method. The surface morphology was characterized by SEM and TEM. The CMGO was selected as the adsorbent for the magnetic solid phase extraction (MSPE) of sulfonamides (SAs) from environmental water samples, and the eluted analytes were determined by ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)...
September 8, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30227884/the-effect-of-virtual-reality-based-balance-training-on-motor-learning-and-postural-control-in-healthy-adults-a-randomized-preliminary-study
#17
Thunyanoot Prasertsakul, Panya Kaimuk, Wipawee Chinjenpradit, Weerawat Limroongreungrat, Warakorn Charoensuk
BACKGROUND: Adults with sedentary lifestyles seem to face a higher risk of falling in their later years. Several causes, such as impairment of strength, coordination, and cognitive function, influence worsening health conditions, including balancing ability. Many modalities can be applied to improve the balance function and prevent falling. Several studies have also recorded the effects of balance training in elderly adults for fall prevention. Accordingly, the aim of this study is to define the effect of virtual reality-based balance training on motor learning and postural control abilities in healthy adults...
September 18, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/30227667/influence-of-milling-parameters-on-mechanical-properties-of-aa7075-aluminum-under-corrosion-conditions
#18
María Jesús Martín, María José Cano, Germán Castillo, Manuel José Herrera, Francisco Martín
The paper describes an experimental study developed on the AA7075 T651, which is an aluminum alloy extensively used in the aeronautical industry. This work presents a double approach of investigation where there is no literature about previous research. This includes the analysis of the results obtained by the combination of mechanical and chemical actions on the mechanical properties of this material. On the one hand, the combinations of relevant milling parameters (feed rate, cutting speed) on flat samples (flat specimens have been selected by attempting to reproduce with the most accurate way the geometry and the type of machining process known as face milling is usually used in this manufacturing field)...
September 17, 2018: Materials
https://www.readbyqxmd.com/read/30227092/bonding-strength-of-orthodontic-brackets-on-porcelain-surfaces-etched-by-er-yag-laser
#19
Zhuojun Xu, Jing Li, Xiaochuan Fan, Xiaofeng Huang
OBJECTIVE: To evaluate the effect of erbium: yttrium aluminium garnet laser conditioning bond strength of orthodontic brackets on porcelain surfaces. BACKGROUND: There are few studies that evaluate the effect of Er:YAG laser about orthodontic bonding on porcelain surface. The efficacy of Er:YAG laser in porcelain conditioning is controversial. MATERIALS AND METHODS: Ninety ceramic specimens were randomly divided into five group, group A: etched with hydrofluoric (HF) acid; group B and C: etched with an energy parameter of 250 mJ, 20 Hz and 300 mJ, 20 Hz by Er:YAG laser instrument; group D and E: etched with an energy parameter of 250 mJ, 20 Hz and 300 mJ, 20 Hz of Er:YAG laser with HF etching...
September 18, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/30226869/age-affects-myosin-relaxation-states-in-skeletal-muscle-fibers-of-female-but-not-male-mice
#20
Lien A Phung, Sira M Karvinen, Brett A Colson, David D Thomas, Dawn A Lowe
The recent discovery that myosin has two distinct states in relaxed muscle-disordered relaxed (DRX) and super-relaxed (SRX)-provides another factor to consider in our fundamental understanding of the aging mechanism in skeletal muscle, since myosin is thought to be a potential contributor to dynapenia (age-associated loss of muscle strength independent of atrophy). The primary goal of this study was to determine the effects of age on DRX and SRX states and to examine their sex specificity. We have used quantitative fluorescence microscopy of the fluorescent nucleotide analog 2'/3'-O-(N-methylanthraniloyl) ATP (mantATP) to measure single-nucleotide turnover kinetics of myosin in skinned skeletal muscle fibers under relaxing conditions...
2018: PloS One
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