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Hepatitis b pharmacist

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https://www.readbyqxmd.com/read/27716978/influence-of-successful-chronic-hepatitis-c-virus-treatment-with-ledipasvir-sofosbuvir-on-warfarin-dosing-requirements-in-four-veterans
#1
Sara R Britnell, Amy E Willets, Adam J Vanderman, Catherine L Woodard, Rachel B Britt
STUDY OBJECTIVE: To describe international normalized ratio (INR) trends and warfarin dosage adjustments required for four veterans who were receiving warfarin therapy and started treatment for hepatitis C virus (HCV) with ledipasvir/sofosbuvir with or without ribavirin. DESIGN: Case series. SETTING: Pharmacist-led anticoagulation clinic in a Veterans Affairs Health Care System. PATIENTS: Four patients aged 59-66 years who were receiving warfarin and had stable, therapeutic INRs and started ledipasvir/sofosbuvir therapy with or without ribavirin for HCV infection...
October 7, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27450138/the-impact-of-pharmacist-immunization-programs-on-adult-immunization-rates-a-systematic-review-and-meta-analysis
#2
Justin Baroy, Danny Chung, Ryan Frisch, David Apgar, Marion K Slack
OBJECTIVES: To estimate the impact that pharmacist immunization programs have on immunization rates. DATA SOURCES: Pubmed, Ovid/Medline, and Google Scholar were searched. References were checked and citation searches using identified studies conducted. STUDY SELECTION: Studies were eligible for the systematic review and meta-analysis if the study compared pharmacist as immunizer versus usual care. Any study design that involved a comparison group was acceptable...
July 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/26846728/therapeutic-advances-in-hcv-genotype-1-infection-insights-from-the-society-of-infectious-diseases-pharmacists
#3
REVIEW
Paulina Deming, Michelle T Martin, Juliana Chan, Thomas J Dilworth, Rania El-Lababidi, Bryan L Love, Rima A Mohammad, Amy Nguyen, Linda M Spooner, Suzanne B Wortman
Hepatitis C virus (HCV) is the most common blood-borne infection in the United States. The high morbidity and mortality due to untreated infection have prompted updated screening recommendations that now include one-time HCV screening for all patients born between 1945 and 1965, in addition to risk factor-based screening. Current guidelines recommend treatment for all patients with chronic HCV. Treatment for HCV genotype 1 has evolved dramatically since the approval of the direct-acting antivirals. The approval of ledipasvir-sofosbuvir, ombitasvir-paritaprevir-ritonavir and dasabuvir, and simeprevir with sofosbuvir has dramatically altered the treatment landscape...
February 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26629725/canadian-contraception-consensus-part-2-of-4
#4
Amanda Black, Edith Guilbert, Dustin Costescu, Sheila Dunn, William Fisher, Sari Kives, Melissa Mirosh, Wendy V Norman, Helen Pymar, Robert Reid, Geneviève Roy, Hannah Varto, Ashley Waddington, Marie-Soleil Wagner, Anne Marie Whelan, Carrie Ferguson, Claude Fortin, Maria Kielly, Shireen Mansouri, Nicole Todd
OBJECTIVE: To provide guidelines for health care providers on the use of contraceptive methods to prevent pregnancy and on the promotion of healthy sexuality. OUTCOMES: Guidance for Canadian practitioners on overall effectiveness, mechanism of action, indications, contraindications, non-contraceptive benefits, side effects and risks, and initiation of cited contraceptive methods; family planning in the context of sexual health and general well-being; contraceptive counselling methods; and access to, and availability of, cited contraceptive methods in Canada...
November 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/26606712/canadian-contraception-consensus-part-1-of-4
#5
Amanda Black, Edith Guilbert, Dustin Costescu, Sheila Dunn, William Fisher, Sari Kives, Melissa Mirosh, Wendy V Norman, Helen Pymar, Robert Reid, Geneviève Roy, Hannah Varto, Ashley Waddington, Marie-Soleil Wagner, Anne Marie Whelan, Carrie Ferguson, Claude Fortin, Maria Kielly, Shireen Mansouri, Nicole Todd
OBJECTIVE: To provide guidelines for health care providers on the use of contraceptive methods to prevent pregnancy and on the promotion of healthy sexuality. OUTCOMES: Guidance for Canadian practitioners on overall effectiveness, mechanism of action, indications, contraindications, non-contraceptive benefits, side effects and risks, and initiation of cited contraceptive methods; family planning in the context of sexual health and general well-being; contraceptive counselling methods; and access to, and availability of, cited contraceptive methods in Canada...
October 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/26037234/structural-basis-for-polymer-packing-and-solvation-properties-of-the-organogermanium-crystalline-polymer-propagermanium-and-its-derivatives
#6
COMPARATIVE STUDY
Nobuhiro Mizuno, Eiji Nishibori, Mitsuru Oka, Takahito Jomori, Masaki Takata, Takashi Kumasaka
Of organogermanium compounds known to have an immunostimulatory action, propagermanium [PGe; 3-oxygermylpropionic acid polymer, (C3 H5 GeO3.5 )n] is the only one used as a pharmaceutical agent, to treat the hepatitis B virus in Japan. However, because of lack of information about its structure, PGe has been confused with a polymeric solid, repagermanium (RGe, Ge-132, poly-trans-[(2-carboxyethyl) germasesquioxane], (C18 H30 Ge6 O21 )n), which has the same essential formula as PGe. To clarify this issue, the structure of PGe was analyzed using X-ray diffraction (XRD)...
August 2015: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25964830/is-response-guided-therapy-being-applied-in-the-clinical-setting-the-hepatitis-c-example
#7
Jennifer B Harris, Melea A Ward, Phil Schwab
BACKGROUND: Response-guided therapy (RGT) is a treatment model that bases adjustments to therapeutic regimens on individualized patient physiologic response. This approach is applied to patients with chronic hepatitis C virus (HCV) infection who are treated with a triple therapy regimen of boceprevir or telaprevir in combination with pegylated interferon and ribavirin. As RGT expands in other pharmacologic regimens, including the treatment of breast cancer and acute myeloid leukemia, a measurement of how this approach is applied in clinical practice is important to determine whether the benefits of RGT are being optimized...
February 2015: American Health & Drug Benefits
https://www.readbyqxmd.com/read/25685549/knowledge-of-hepatitis-b-virus-infection-immunization-with-hepatitis-b-vaccine-risk-perception-and-challenges-to-control-hepatitis-among-hospital-workers-in-a-nigerian-tertiary-hospital
#8
Olusegun Adekanle, Dennis A Ndububa, Samuel Anu Olowookere, Oluwasegun Ijarotimi, Kayode Thaddeus Ijadunola
Background. Studies had reported high rate of hepatitis B infection among hospital workers with low participation in vaccination programmes, especially those whose work exposes them to the risk of HBV infection. The study assessed knowledge of hepatitis B virus infection, risk perception, vaccination history, and challenges to control hepatitis among health workers. Methods. A descriptive cross-sectional study. Consenting health care workers completed a self-administered questionnaire that assessed respondents' general knowledge of HBV, vaccination history and HBsAg status, risk perception, and challenges to control hepatitis...
2015: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25615903/using-motivational-interviewing-in-the-community-pharmacy-to-increase-adult-immunization-readiness-a-pilot-evaluation
#9
Amber Brackett, Michell Butler, Liza Chapman
OBJECTIVES: To investigate whether the use of motivational interviewing (MI) in the community pharmacy improves immunization readiness and rates for hepatitis B, hepatitis A/B combination, herpes zoster, pneumococcal, and tetanus-diphtheria-acellular pertussis immunizations. SETTING: Kroger Pharmacy. PRACTICE DESCRIPTION: Grocery store pharmacies located in the Atlanta, GA, metropolitan area offering a variety of patient care services, including medication therapy management and immunizations...
March 2015: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/25470455/development-of-a-high-throughput-screening-platform-to-study-the-adsorption-of-antigens-onto-aluminum-containing-adjuvants
#10
Vanessa Jully, Nicolas Moniotte, Frédéric Mathot, Dominique Lemoine, Véronique Préat
Aluminum-containing salts are important adjuvants in the formulations of many licensed human vaccines. However, in the early stage of the design of a new vaccine, a thorough understanding of the adsorption mechanisms of an antigen onto an aluminum salt is required. Therefore, we have developed a robust, rapid, and reproducible high-throughput screening (HTS) platform to study the adsorption capacity of aluminum-containing vaccines. The adsorption isotherms on aluminum hydroxide and aluminum phosphate of two model proteins, β-casein, and bovine serum albumin, were evaluated using a liquid handling system, which permitted rapid sample preparation in a small volume without nonspecific adsorption...
February 2015: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25278667/pharmaceutical-care-outcomes-in-an-outpatient-human-immunodeficiency-virus-treatment-center-in-jos-nigeria
#11
Isaac O Abah, Victor B Ojeh, Kakjing D Falang, Kristin M Darin, Oluremi O Olaitan, Oche O Agbaji
RATIONALE: Pharmacotherapy for patients infected with human immunodeficiency virus (HIV) is complex and increases the potential for drug therapy problems (DTPs). We described the frequency and type of DTPs in a Nigerian cohort of HIV infected patients on antiretroviral therapy (ART), as well as the changes in HIV clinical outcomes after pharmacists' intervention. METHODS: A prospective 1-year descriptive study was conducted from July 2010 to June 2011, at the adult HIV clinic of Jos University Teaching Hospital, Nigeria...
June 2014: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/25062078/concurrent-use-of-comedications-reduces-adherence-to-antiretroviral-therapy-among-hiv-infected-patients
#12
Maria Rosa Cantudo-Cuenca, Rocio Jiménez-Galán, Carmen V Almeida-Gonzalez, Ramón Morillo-Verdugo
BACKGROUND: The use of highly active antiretroviral therapy has significantly reduced morbidity and mortality, thus increasing life expectancy of human immunodeficiency virus (HIV)-infected individuals, transforming HIV into a chronic disease. Accordingly, there has been an increase in the number of comorbidities concomitantly present in these individuals and also an increased use of comedications, which may negatively impact antiretroviral therapy adherence. These factors can affect adherence to antiretroviral therapy...
August 2014: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/24856591/a-population-approach-to-disease-management-hepatitis-c-direct-acting-antiviral-use-in-a-large-health-care-system
#13
COMPARATIVE STUDY
Pamela S Belperio, Lisa I Backus, David Ross, Melinda M Neuhauser, Larry A Mole
BACKGROUND: The introduction of the first direct-acting antiviral agents (DAAs) for the treatment of hepatitis C virus (HCV), telaprevir and boceprevir, marked a unique event in which 2 disease-changing therapies received FDA approval at the same time. Comparative safety and effectiveness data in real-world populations upon which to make formulary decisions did not exist. OBJECTIVE: To describe the implementation, measurement, and outcomes of an enduring population-based approach of surveillance of medication management for HCV...
June 2014: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/24630314/-perception-of-vaccination-and-role-of-the-pharmacist-a-survey-among-final-year-pharmacy-students-in-france
#14
J-C Comboroure, J-E Mueller
INTRODUCTION: In France, the « HPST » law of 21 July 2009 assigns new responsibilities to pharmacists. Given the fact that the majority of vaccination coverage targets set by the Public Health Act of August 9, 2004 is not met, the question arises in how far pharmacies in town can contribute to better promotion and accessibility of vaccination. The objective of this investigation was to describe the perception of vaccination by final year pharmacy students and how they see their future professional contribution to improving vaccination coverage...
March 2014: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/24521593/antimicrobial-stewardship-program-to-reduce-antiretroviral-medication-errors-in-hospitalized-patients-with-human-immunodeficiency-virus-infection
#15
Jamie Sanders, Andrea Pallotta, Seth Bauer, Jennifer Sekeres, Ramona Davis, Alan Taege, Elizabeth Neuner
OBJECTIVE: Evaluate antimicrobial stewardship interventions targeted to reduce highly active antiretroviral therapy (HAART)- or opportunistic infection (OI)-related medication errors and increase error resolution. DESIGN: Retrospective before-after study. SETTING: Academic medical center. PATIENTS: Inpatients who were prescribed antiretroviral therapy before the intervention (January 1, 2011, to October 31, 2011) and after the intervention (July 1, 2012, to December 31, 2012)...
March 2014: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/24359204/pain-management-in-a-patient-with-renal-and-hepatic-dysfunction
#16
David B Brecher, Tasheba L West
BACKGROUND: Palliative medicine providers are often consulted to provide guidance for pain relief for a diverse population. End-of-life care is often challenging, balancing optimum pain relief with minimal side effects. Patients with both renal and hepatic dysfunction are particularly challenging when considering appropriate treatments. CONCLUSION: This case discussion highlights an end-of-life pain symptom management challenge, and the associated pharmacological background...
February 2014: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/23970571/population-based-prevalence-of-hepatitis-b-and-c-virus-hiv-syphilis-gonorrhoea-and-chlamydia-in-male-injection-drug-users-in-lagos-nigeria
#17
W Tun, L Vu, S B Adebajo, L Abiodun, M Sheehy, A Karlyn, J Njab, B Ahonsi, B K Issa, O Idogho
There is little research on injecting drug use in Nigeria. We investigated the prevalence of HIV, hepatitis B and C, and sexually transmitted infections (STIs) among male injection drug users (IDUs) in Lagos. Male IDUs (N = 328) were recruited through respondent-driven sampling. Participants completed an interview about their sexual and injecting risk behaviours and were tested for hepatitis B surface antigen (HBV), hepatitis C antibody (HCV), HIV and syphilis, as well as genital chlamydia and gonorrhoea infections...
August 2013: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/23696170/intravenous-needle-free-injection-devices-new-information-for-compounding-pharmacists
#18
Denise Macklin, Paul L Blackburn
By educating their clients (especially prescribing physicians, nurses, and home healthcare aides) about the advantages of using needle-free devices to administer intravenous medications, compounding pharmacists can help prevent complications associated with vascular access devices and needlestick injuries. Despite state and federal efforts to reduce the incidence of sharps injuries among healthcare workers, percutaneous needle-stick injuries remain a source of emotional stress, morbidity, and possible mortality in those individuals...
March 2013: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/23494893/toward-a-new-paradigm-for-the-efficient-in-vitro-in-vivo-extrapolation-of-metabolic-clearance-in-humans-from-hepatocyte-data
#19
Patrick Poulin, Sami Haddad
The objective of this study was to follow up a previous study on a comparative analysis of diverse in vitro-in vivo extrapolation (IVIVE) methods used for predicting hepatic metabolic clearance (CL) of drugs from intrinsic clearance (CLint ) data determined in microsomal incubations, but using hepatocyte data instead. Six IVIVE methods were compared: the "conventional and conventional bias-corrected methods," the "regression equation method," the "direct scaling method," the "Berezhkovskiy's method," and the "novel IVIVE method of Poulin et al...
September 2013: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/23383700/improvement-in-safety-monitoring-of-biologic-response-modifiers-after-the-implementation-of-clinical-care-guidelines-by-a-specialty
#20
Rebekah L Hanson, Michael J Gannon, Nehrin Khamo, Monsheel Sodhi, Alexander M Orr, JoAnn Stubbings
BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors and other biologic response modifiers (BRMs) are frequently used to treat a variety of inflammatory diseases. Use of these agents may increase risk of serious infections, malignancies, and other complications such as worsening symptoms of heart failure or demyelinating disease. Because of these risks, a baseline assessment and routine monitoring have been recommended, but standardized guidelines for monitoring have yet to be established...
January 2013: Journal of Managed Care Pharmacy: JMCP
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