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Guillain-Barre syndrom

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https://www.readbyqxmd.com/read/28719506/zika-virus-associated-ocular-and-neurologic-disorders-the-emergence-of-new-evidence
#1
Fatih Şahiner, Ali Korhan Siğ, Ümit Savaşçi, Kemal Tekin, Fahrettin Akay
BACKGROUND: It has been approximately 70 years since the discovery of the Zika virus (ZIKV). It had been established that the virus causes mild infections, and is confined to Africa and Asia; however, major changes in the clinical and epidemiologic patterns of ZIKV infection have occurred in recent years. The virus has attracted intense interest because of the possible association of several autoimmune and neurodevelopmental disorders. METHODS: We present a summary of the articles that attempt to explain the ZIKV unknowns, and strengthen the association with some disorders that are thought to be related to ZIKV, by describing the discovery milestones from the initial identification of the virus to the present day...
July 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28716913/antibody-based-assay-discriminates-zika-virus-infection-from-other-flaviviruses
#2
Angel Balmaseda, Karin Stettler, Raquel Medialdea-Carrera, Damaris Collado, Xia Jin, José Victor Zambrana, Stefano Jaconi, Elisabetta Cameroni, Saira Saborio, Francesca Rovida, Elena Percivalle, Samreen Ijaz, Steve Dicks, Ines Ushiro-Lumb, Luisa Barzon, Patricia Siqueira, David W G Brown, Fausto Baldanti, Richard Tedder, Maria Zambon, A M Bispo de Filippis, Eva Harris, Davide Corti
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas. ZIKV infection mostly causes mild disease, but is linked to devastating congenital birth defects and Guillain-Barré syndrome in adults. The high level of cross-reactivity among flaviviruses and their cocirculation has complicated serological approaches to differentially detect ZIKV and dengue virus (DENV) infections, accentuating the urgent need for a specific and sensitive serological test...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28714395/five-decades-of-cuprizone-an-updated-model-to-replicate-demyelinating-diseases
#3
Jose M Vega-Riquer, Gerardo Mendez-Victoriano, Raul A Morales-Luckie, Oscar Gonzalez-Perez
Multiple sclerosis, Guillain-Barré syndrome, peripheral nerve polyneuropathy and others comprise a group of demyelinating diseases characterized by progressive (and eventually irreversible) loss of oligodendrocytes and myelin sheaths in the white matter of the brain. To date, the etiology of these disorders is not well known and no effective treatments are currently available. Therefore, further research is needed to gain a better understand and treat these patients. To accomplish this goal, it is necessary to have appropriate animal models that closely resemble the pathophysiology of these diseases...
July 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28713530/are-cerebrospinal-fluid-protein-levels-and-plasma-neutrophil-lymphocyte-ratio-associated-with-prognosis-of-guillain-barr%C3%A3-syndrome
#4
Sevki Sahin, Nilgun Cinar, Sibel Karsidag
Guillain Barré syndrome (GBS) is a post-infectious acute autoimmune polyradiculopathy. Cerebrospinal fluid (CSF) total protein level and plasma neutrophil/lymphocyte ratio (NLR) are related with autoimmune response. We aimed to reach a prognostic indicator for GBS by using electrophysiological findings, protein level of CSF, and plasma NLR based on Medical Research Council (MRC) sum score data. Cases who met diagnostic criteria of GBS and followed at least six months were enrolled in the study. Nerve conduction study (NCS) and lumbar puncture were performed one week after symptom onset...
June 23, 2017: Neurology International
https://www.readbyqxmd.com/read/28712937/returning-ex-patriot-chinese-to-guangdong-china-increase-the-risk-for-local-transmission-of-zika-virus
#5
Jiufeng Sun, de Wu, Haojie Zhong, Dawei Guan, Huan Zhang, Qiqi Tan, Huiqiong Zhou, Meng Zhang, Dan Ning, Baohuan Zhang, Changwen Ke, Tie Song, Jinyan Lin, Yonghui Zhang, Marion Koopmans, George F Gao
OBJECTIVES: Rapid transmission and linkage to microcephaly and Guillain-Barre syndrome have made Zika virus (ZIKV) infection become a serious threat to global public health. The epidemiology, virological characteristics and genetic evolution of introduced ZIKV to Guangdong, China, were investigated. METHODS: Analyses of the epidemiological characteristics and genetic diversity of ZIKV isolates were performed. RESULTS: Nineteen confirmed ZIKV infection cases were imported from Venezuela and Samoa...
July 13, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28711274/clinical-association-lyme-disease-and-guillain-barre-syndrome
#6
Kinner Patel, Siddharth Shah, Dinesh Subedi
Guillain-Barre Syndrome (GBS) is a life-threatening condition in which patients may present to the Emergency Department in respiratory distress leading to death. The early identification and treatment of such a condition is paramount in preventing mortality. While there are many infections associated with GBS, the association with Lyme disease is uncommon. Through our case we aim to highlight Borrelia burgdorferi as an important antecedent infection associated with the development of GBS. In this case we report a 31-year-old male who was diagnosed with Lyme disease and GBS with relevant clinical presentation including progressive numbness and weakness in bilateral hands and feet for the past 1week along with areflexia...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28710191/unusual-sensory-variant-of-guillain-barr%C3%A3-syndrome
#7
Milena Semproni, Gillian Gibson, Laura Kuyper, Penny Tam
We describe a 52-year-old woman presenting with acute onset of severe burning paraesthesia in the hands and feet associated with allodynia and antalgic gait. At the time of admission to hospital no motor weakness was present. A diagnosis of Guillain-Barré syndrome (GBS) was considered when neurophysiological studies were completed showing convincing evidence of demyelination on motor conduction studies and sural sparing on sensory nerve studies.(1) We describe this case as a sensory variant of GBS. Clinical improvement followed treatment with a single course of intravenous immunoglobulin (IVIG)...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28708086/celiac-disease-presenting-with-peripheral-neuropathy-in-children-a-case-report
#8
Alessandra Pacitto, Alessandra Paglino, Lorenza Di Genova, Alberto Leonardi, Edoardo Farinelli, Nicola Principi, Giuseppe di Cara, Susanna Esposito
Background: Clinically relevant neurological manifestations in children with celiac disease (CD) are unusual, especially when they are considered as signs of the onset of the disease. In this paper, a case of Guillain-Barrè syndrome (GBS) as the first manifestation of CD in a 23-month-old child is reported. Case presentation: We describe a case of CD onset with peripheral neuropathy in a 23-month-old Bulgarian boy presenting with a sudden refusal to walk and absence of deep tendon reflexes in both lower limbs...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28706599/acute-fulminant-uremic-neuropathy-following-coronary-angiography-mimicking-guillain-barre-syndrome
#9
Kumari Priti, Bhanwar Ranwa
A 55-year-old diabetic woman suffered a posterior wall ST-elevation myocardial infarction. She developed contrast-induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan-Barre Syndrome, hence reported.
April 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28700665/solution-conformations-of-zika-ns2b-ns3pro-and-its-inhibition-by-natural-products-from-edible-plants
#10
Amrita Roy, Liangzhong Lim, Shagun Srivastava, Yimei Lu, Jianxing Song
The recent Zika viral (ZIKV) epidemic has been associated with severe neurological pathologies such as neonatal microcephaly and Guillain-Barre syndrome but unfortunately no vaccine or medication is effectively available yet. Zika NS2B-NS3pro is essential for the proteolysis of the viral polyprotein and thereby viral replication. Thus NS2B-NS3pro represents an attractive target for anti-Zika drug discovery/design. Here, we have characterized the solution conformations and catalytic parameters of both linked and unlinked Zika NS2B-NS3pro complexes and found that the unlinked complex manifested well-dispersed NMR spectra...
2017: PloS One
https://www.readbyqxmd.com/read/28694640/guillain-barre-syndrome-in-postpartum-period-rehabilitation-issues-and-outcome-three-case-reports
#11
Anupam Gupta, Maitreyi Patil, Meeka Khanna, Rashmi Krishnan, Arun B Taly
We report three females who developed Guillain-Barre Syndrome in postpartum period (within 6 weeks of delivery) and were admitted in the Neurological Rehabilitation Department for rehabilitation after the initial diagnosis and treatment in the Department of Neurology. The first case, axonal variant (acute motor axonal neuropathy [AMAN]) had worst presentation at the time of admission, recovered well by the time of discharge. The second case, acute motor sensory axonal neuropathy variant and the third case, AMAN variant presented at the late postpartum period...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28694622/pulmonary-involvement-in-patients-with-guillain-barr%C3%A3-syndrome-in-subacute-phase
#12
Meeka Khanna, Nidhi Rawat, Anupam Gupta, Madhu Nagappa, Arun B Taly, M R Rukmani, T N Sathyaprabha, Partha Haldar
OBJECTIVES: To evaluate the pulmonary function in Guillain-Barre syndrome (GBS) patients in subacute phase and find clinical correlates of pulmonary dysfunction. METHODS: This was a single-center, prospective, cross-sectional, hospital-based study in GBS patients performed in Department of Neurological Rehabilitation at a tertiary care institute. Clinical examination for pulmonary function was done by measuring chest expansion. The pulmonary function tests were carried out by Spirometry kit Microquark Cosmed, Italy...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28694605/respiratory-involvement-in-guillain-barre-syndrome-the-uncharted-road-to-recovery
#13
EDITORIAL
Meenal Garg
No abstract text is available yet for this article.
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28694390/in-vitro-susceptibility-of-geographically-and-temporally-distinct-zika-viruses-to-favipiravir-and-ribavirin
#14
Mariana Baz, Nathalie Goyette, Bryan D Griffin, Gary P Kobinger, Guy Boivin
BACKGROUND: Zika virus (ZIKV), a previously neglected mosquito-borne virus, is prompting worldwide concern because of its connection with congenital defects, Guillain-Barré syndrome, meningoencephalitis and myelitis in infected individuals. However, no specific antiviral therapy is available at present. In this study, we investigated the in vitro susceptibility of geographically and temporally distinct zika viruses against the RNA polymerase inhibitors, favipiravir (T-705) and ribavirin (RIBV)...
July 11, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28688623/neuropsychiatric-debut-as-a-presentation-of-guillain-barr%C3%A3-syndrome-an-atypical-clinical-case-and-literature-review
#15
Dinesh Sangroula, Richard Durrance, Shirshak Bhattarai, Thambirajah Nandakumar
INTRODUCTION: Guillain Barré Syndrome (GBS) is an acute immune-mediated polyneuropathy most frequently presenting two to four weeks after an acute mild-moderately severe infection as progressive muscular weakness of the lower limbs extending proximally with dysreflexia and autonomic dysfunction. While GBS is typically believed to be isolated to the Peripheral Nervous System, Central Nervous System (CNS) and psychiatric manifestations as a sequela of the disease have been described in different imaging and clinical studies...
July 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28686621/risk-of-bias-and-confounding-of-observational-studies-of-zika-virus-infection-a-scoping-review-of-research-protocols
#16
Ludovic Reveiz, Michelle M Haby, Ruth Martínez-Vega, Carlos E Pinzón-Flores, Vanessa Elias, Emma Smith, Mariona Pinart, Nathalie Broutet, Francisco Becerra-Posada, Sylvain Aldighieri, Maria D Van Kerkhove
INTRODUCTION: Given the severity and impact of the current Zika virus (ZIKV) outbreak in the Americas, numerous countries have rushed to develop research studies to assess ZIKV and its potential health consequences. In an effort to ensure that studies are comprehensive, both internally and externally valid, and with reliable results, the World Health Organization, the Pan American Health Organization, Institut Pasteur, the networks of Fiocruz, the Consortia for the Standardization of Influenza Seroepidemiology (CONSISE) and the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) have generated six standardized clinical and epidemiological research protocols and questionnaires to address key public health questions on ZIKV...
2017: PloS One
https://www.readbyqxmd.com/read/28686532/management-of-hydrocephalus-associated-with-autoimmune-diseases-a-series-of-19-cases
#17
Baitao Ma, Hao Wu, Hexiang Yin, Jianbo Chang, Li Wang, Renzhi Wang, Wenbin Ma, Yongning Li, Jian Guan, Jinjing Liu, Junji Wei
OBJECTIVES: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients. METHODS: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Medical records were screened for data regarding (1) the number of patients diagnosed with hydrocephalus associated with autoimmune diseases, (2) the clinical manifestation of hydrocephalus associated with autoimmune disease, and (3) the outcomes of these patients treated with medication or ventriculoperitoneal shunt (VPS)...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28684012/-high-blood-pressure-during-the-autonomic-crises-in-children-in-intensive-care-unit-etiologic-circumstances-and-modality-therapeutic
#18
D D Batouche, M Benatta, R Okbani, N F Benatta
The dysautonomic (DC) or neurovegetative crisis remains an imperfectly known entity; it associates in a paroxysmal manner a reaction of sympathetic hyperreactivity that can lead to the prognosis. Our objective is to specify the etiological circumstances (DC) and their modality of treatment in pediatric intensive care unit. MATERIALS-METHODS: Descriptive study on files of children admitted in the intensive care unit of 2010-2015 who presented a DC acquired during their hospitalization...
July 3, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28682187/making-vaccine-messaging-stick-perceived-causal-instability-as-a-barrier-to-effective-vaccine-messaging
#19
Graham N Dixon
Health officials often face challenges in communicating the risks associated with not vaccinating, where persuasive messages can fail to elicit desired responses. However, the mechanisms behind these failures have not been fully ascertained. To address this gap, an experiment (N = 163) tested the differences between loss-framed messages-one emphasizing the consequence of not receiving a flu vaccine; the other emphasizing the consequence of receiving the flu vaccine. Despite an identical consequence (i.e., Guillain-Barre syndrome), the message highlighting the consequence of not receiving the flu vaccine produced lower negative affect scores as compared to the message highlighting the consequence of receiving the flu vaccine...
July 6, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28681756/familial-guillain-barr%C3%A3-syndrome-a-case-report-with-literature-review
#20
Binod Sarmah, Narayan Upadhyaya
Guillain-Barré syndrome (GBS) is the most common acute immune-mediated polyneuropathy characterized by symmetrical weakness of limbs and hyporeflexia or areflexia. Familial occurrence of GBS is rare, and only 42 patients from 20 families have been reported so far. Majority of them are from European countries. Familial occurrences do suggest the involvement of some as yet unidentified genetic susceptibility factors. We report the clinical and detailed electrophysiological findings of three affected brothers from Arunachal Pradesh who presented with possible familial GBS...
July 2017: Neurology India
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