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Guillain-Barre syndrom

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https://www.readbyqxmd.com/read/29237657/rare-side-effect-of-adjuvant-ipilimumab-after-surgical-resection-of-melanoma-guillain-barr%C3%A3-syndrome
#1
Rohini J Patel, Michael A Liu, Akshay Amaraneni, Simran K Sindhu
Guillain-Barré syndrome is a life-threatening neurological disorder that presents with rapid ascending paralysis and areflexia. Guillain-Barré syndrome is traditionally associated with infections from a gastrointestinal or respiratory tract source. We report the case of a 71-year-old man with melanoma who was treated with ipilimumab as adjuvant immunotherapy and subsequently developed Guillain-Barré syndrome. The diagnosis was made clinically through physical exam findings. He was successfully treated with a combination of intravenous immunoglobulin therapy and corticosteroids...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29235414/zikaplan-zika-preparedness-latin-american-network
#2
A Wilder-Smith, R Preet, K E Renhorn, R A Ximenes, L C Rodrigues, T Solomon, J Neyts, L Lambrechts, H Willison, R Peeling, A K Falconar, A R Precioso, J Logan, T Lang, H P Endtz, M C Erasmus, E Massad
The ongoing Zika virus (ZIKV) outbreak in Latin America, the Caribbean, and the Pacific Islands has underlined the need for a coordinated research network across the whole region that can respond rapidly to address the current knowledge gaps in Zika and enhance research preparedness beyond Zika. The European Union under its Horizon 2020 Research and Innovation Programme awarded three research consortia to respond to this need. Here we present the ZikaPLAN (Zika Preparedness Latin American Network) consortium...
2017: Global Health Action
https://www.readbyqxmd.com/read/29232807/retrospective-analysis-and-comment-on-the-time-interval-between-surgery-and-onset-of-guillain-barr%C3%A3-syndrome
#3
Bao Qi, Chunyang Meng
No abstract text is available yet for this article.
January 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29212931/suppression-of-zika-virus-infection-and-replication-in-endothelial-cells-and-astrocytes-by-pka-inhibitor-pki-14-22
#4
Fan Cheng, Suzane Ramos da Silva, I-Chueh Huang, Jae U Jung, Shou-Jiang Gao
The recent outbreak of Zika virus (ZIKV), a re-emerging flavivirus, and its associated neurological disorders, such as Guillain-Barré (GB) syndrome and microcephaly, have generated an urgent need for developing effective ZIKV vaccines and therapeutic agents. Here, we used human endothelial cells and astrocytes, both of which represent key cell types for ZIKV infection, to identify potential inhibitors for ZIKV replication. Because several pathways, including AMP-activated protein kinase (AMPK), protein kinase A (PKA), and mitogen-activated protein kinase (MAPK) signaling pathways, have been reported to play important roles in flavivirus replication, we tested inhibitors or agonists of these pathways for their effects on ZIKV replication...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29207765/syndrome-of-inappropriate-secretion-of-antidiuretic-hormone-preceding-guillain-barr%C3%A3-syndrome
#5
Joe James, James Jose
Guillain-Barré Syndrome (GBS) is an inflammatory polyradiculoneuropathy which is known to produce syndrome of inappropriate Secretion of Antidiuretic Hormone (SIADH). However, the hyponatremia is usually seen after the onset of weakness. Here, we report a case of SIADH that presented with hyponatremic seizures which preceded the onset of GBS by ten days.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207762/guillain-barre-syndrome-with-falciparum-malaria-and-scrub-typhus-mixed-infection-an-unusual-combination
#6
Rahul Sai Gangula, Weena Stanley, Arunsheshu Vandanapu, M Mukhyaprana Prabhu
Guillain-Barre Syndrome is very rare in parasitic and rickettsial infection. Here we report a case of Plasmodium falciparum and scrub typhus mixed infection, presented with quadriparesis. Clinical, Serological, CSF analysis and Nerve Conduction Studies were consistent with Acute Inflammatory Demyelinating Polyneuropathy (variant of GBS). After administration of antimalarials and antibiotics for the mixed infection, patient gradually improved.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29202623/nonclinical-development-of-anx005-a-humanized-anti-c1q-antibody-for-treatment-of-autoimmune-and-neurodegenerative-diseases
#7
Janice A Lansita, Kirsten M Mease, Haiyan Qiu, Ted Yednock, Sethu Sankaranarayanan, Susan Kramer
ANX005 is a humanized immunoglobulin G4 recombinant antibody against C1q that inhibits its function as the initiating molecule of the classical complement cascade. The safety and tolerability of ANX005 are currently being evaluated in a phase I trial in healthy volunteers ( www.clinicaltrials.gov Identifier: NCT03010046). Inhibition of C1q can be applied therapeutically in a broad spectrum of diseases, including acute antibody-mediated autoimmune disease, such as Guillain-Barré syndrome (GBS), and in chronic diseases of the central nervous system involving complement-mediated neurodegeneration, such as Alzheimer's disease (AD)...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29201154/lymphatic-system-and-gut-microbiota-affect-immunopathology-of-neuroinflammatory-diseases-including-multiple-sclerosis-neuromyelitis-optica-and-alzheimer-s-disease
#8
Ikuo Tsunoda
Microbial infections lead to neurological damages either by direct infection in the nervous tissues or by uncontrolled immune responses (immunopathology). For example, in Zika virus infection, microcephaly can be caused by the former, i.e., direct viral infection in the brain, while Guillain-Barré syndrome (GBS) seems to be antibody-mediated immunopathology. Although a variety of factors affect immunopathology, two essential systems maintaining whole-body homeostasis had long been neglected: 1) the lymphatic system and 2) microbiota...
August 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/29200423/analysing-increasing-trends-of-guillain-barr%C3%A3-syndrome-gbs-and-dengue-cases-in-hong-kong-using-meteorological-data
#9
Xiujuan Tang, Shi Zhao, Alice P Y Chiu, Xin Wang, Lin Yang, Daihai He
BACKGROUND: Guillain-Barré Syndrome (GBS) is a severe paralytic neuropathy associated with virus infections such as Zika virus and Chikungunya virus. There were also case reports of dengue fever preceding GBS. With the aim to understand the mechanisms of GBS and dengue outbreaks, this ecological study investigates the relationships between GBS, dengue, meteorological factors in Hong Kong and global climatic factors from January 2000 to June 2016. METHODS: The correlations between GBS, dengue, Multivariate El Niño Southern Oscillation Index (MEI) and local meteorological data were explored by Spearman's Rank correlations and cross-correlations...
2017: PloS One
https://www.readbyqxmd.com/read/29193554/do-delays-in-data-availability-limit-the-implementation-of-near-real-time-vaccine-safety-surveillance-using-the-clinical-practice-research-datalink
#10
Andreia Leite, Sara L Thomas, Nick J Andrews
PURPOSE: Near real-time vaccine safety surveillance (NRTVSS) using electronic health records has been used to detect timely vaccine safety signals. Trial implementation of NRTVSS using the Clinical Practice Research Datalink (CPRD) has shown that there is limited power to detect safety signals for rare events. Delays in recording outcomes and receiving data influence the power and timeliness to identify a signal. Our work aimed to compare how different sources of delays influence power and expected time to signal to implement NRTVSS using CPRD...
November 28, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29192644/automated-centrifugal-therapeutic-plasma-exchange-option-for-guillain-barre-syndrome-a-report-from-calabar-nigeria
#11
O E Iheanacho, C Chimeziem, B S Sachais, P A Shi
Therapeutic plasma exchange (TPE) is performed frequently and effectively in developed countries, whereas the reverse is the case in developing countries. Guillain-Barre syndrome (GBS), synonymous with acute inflammatory demyelinating polyneuropathy, is an important indication for TPE, but this is rarely administered in the treatment of such patients in Nigeria due to lack of such automated facility, limited expertise, and high cost. This report therefore presents an uncommon case of GBS in which automated TPE was utilized in the management, with the aims of highlighting the current status and challenges of therapeutic apheresis services in Nigeria...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29190868/-epidemiology-and-human-rights-zika-virus-outlook-and-reproductive-rights-in-latin-america
#12
Manuel G Chávez-Ángeles, Ericay Berenice Martínez-Ramos, Olga López-Hernández
With this article we review the current Zika virus (ZIKV) epidemic. We also look back over the last scientific evidence relating ZIKV to microcephaly and Guillain-Barré syndrome. Finally, we also address the challenges in terms of reproductive rights in Latin America.
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29189556/atypical-asymmetric-guillain-barr%C3%A3-syndrome-with-acute-rhabdomyolysis
#13
Mitch J Hargis
No abstract text is available yet for this article.
December 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29189553/guillain-barr%C3%A3-syndrome-triggered-by-immune-checkpoint-inhibitors-a-case-report-and-literature-review
#14
Songkit Supakornnumporn, Bashar Katirji
Immune checkpoint inhibitors, used as immunotherapy in the treatment of melanoma and refractory cancer, may trigger autoimmune disorders. We describe a case of Guillain-Barré syndrome (GBS) after the treatment with ipilimumab and nivolumab and review 4 other reported cases. We confirmed the diagnosis of GBS by electrodiagnostic and cerebrospinal fluid studies. Electrodiagnostic results showed findings consistent with acquired demyelinating polyneuropathy and cerebrospinal fluid showed albuminocytologic dissociation...
December 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29189549/outcome-of-guillain-barr%C3%A3-syndrome-in-tertiary-care-centers-in-thailand
#15
Kongkiat Kulkantrakorn, Puchit Sukphulloprat
BACKGROUND: Guillain-Barré syndrome (GBS), a common acute polyneuropathy, is seen worldwide with significant morbidity and mortality. GBS consists of a number of subtypes. OBJECTIVE: The aim of this study is to identify clinical characteristics, electrophysiologic changes, clinical course, treatment, and outcome of GBS in Thailand. MATERIAL AND METHODS: Retrospective study of GBS patients aged 15 years or older, admitted to Thammasat University Hospital and Bangkok Hospital Medical Center between January 1, 2009 and November 30, 2014...
December 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29187518/neurofascin-antibodies-in-autoimmune-genetic-and-idiopathic-neuropathies
#16
Elisabeth Burnor, Li Yang, Hao Zhou, Kristina R Patterson, Colin Quinn, Mary M Reilly, Alexander M Rossor, Steven S Scherer, Eric Lancaster
OBJECTIVE: To measure the frequency, persistence, isoform specificity, and clinical correlates of neurofascin antibodies in patients with peripheral neuropathies. METHODS: We studied cohorts of patients with Guillain-Barre syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP) (n = 59), genetic neuropathy (n = 111), and idiopathic neuropathy (n = 43) for immunoglobulin (Ig) G and IgM responses to 3 neurofascin (NF) isoforms (NF140, NF155, and NF186) using cell-based assays...
November 29, 2017: Neurology
https://www.readbyqxmd.com/read/29184340/treatment-related-fluctuations-in-guillain-barre-syndrome-and-the-conundrum-of-additional-cycles-of-plasmapheresis
#17
Subasree Ramakrishnan, Veerendrakumar Mustare, Mariamma Philip, K Thennarasu, Sunder Periyavan
Introduction: In Guillain Barre syndrome (GBS), worsening of weakness or disability after initial period of recovery or stabilization is described as treatment-related fluctuations (TRF). Aim: This study aims to describe the clinical characteristics and outcome of six patients with GBS and TRF. Patients and Methods: Six patients with GBS fulfilling NINCDS criteria, evaluated at a tertiary care university hospital during 2008-2017, were diagnosed to have TRF...
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29182914/detection-of-proximal-conduction-blocks-using-a-triple-stimulation-technique-improves-the-early-diagnosis-of-guillain-barr%C3%A3-syndrome
#18
Amandine Sevy, Aude-Marie Grapperon, Emmanuelle Salort Campana, Emilien Delmont, Shahram Attarian
OBJECTIVE: Current diagnostic electrophysiological criteria can miss the early stages of Guillain-Barré syndrome (GBS). We evaluated the diagnostic efficiency of the triple stimulation technique (TST) in highlighting proximal conduction blocks (CBs) in patients who do not meet the electrophysiological criteria for GBS. METHODS: All patients with a diagnosis of clinical GBS referred to our center between September 2014 and January 2016 were included in the study...
November 11, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29181810/imaging-findings-in-congenital-zika-virus-infection-syndrome-an-update
#19
Andrea Silveira de Souza, Patrícia Soares de Oliveira-Szjenfeld, Adriana Suely de Oliveira Melo, Luis Alberto Moreira de Souza, Alba Gean Medeiros Batista, Fernanda Tovar-Moll
BACKGROUND: Zika virus (ZIKV) is a neurotropic and neurotoxic RNA Flavivirus prompt to cause severe fetal brain dysmorphisms during pregnancy, a period of rapid and critical central nervous system development. A wide range of clinico-radiological findings of congenital ZIKV infections were reported in the literature, such as microcephaly, overlapping sutures, cortical migrational and corpus callosum abnormalities, intracranial calcifications, ventriculomegaly, brain stem and cerebellar malformations, spinal cord involvement, and joint contractures...
November 27, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29167658/atypical-electrophysiological-findings-in-a-patient-with-acute-motor-and-sensory-axonal-neuropathy
#20
Viviana Versace, Stefania Campostrini, Frediano Tezzon, Sara Martignago, Markus Kofler, Leopold Saltuari, Luca Sebastianelli, Raffaele Nardone
Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy with acute onset and rapid clinical worsening; early diagnosis and immunomodulating therapy can ameliorate the course of disease. During the first days, however, nerve conduction studies (NCSs) are not always conclusive. Here, we describe a 73-year-old man presenting with progressive muscular weakness of the lower limbs, ascending to the upper limbs, accompanied by distal sensory disturbances. Neuroimaging of brain and spine and NCSs were unremarkable; cerebrospinal fluid analysis revealed no albuminocytologic dissociation...
2017: Frontiers in Neurology
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