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Guillain-Barre syndrom

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https://www.readbyqxmd.com/read/29692389/guillain-barre-syndrome-complicated-on-postoperation-on-renal-carcinoma-and-meningioma
#1
Shuai Xu, Fen Peng, Yang-Shuo Wang, Shu Li, Hai-Ying Liu
No abstract text is available yet for this article.
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29685816/the-complement-story-in-guillain-barr%C3%A3-syndrome-from-pathogenesis-to-therapy
#2
Eduardo Nobile-Orazio
No abstract text is available yet for this article.
April 20, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29685815/safety-and-efficacy-of-eculizumab-in-guillain-barr%C3%A3-syndrome-a-multicentre-double-blind-randomised-phase-2-trial
#3
Sonoko Misawa, Satoshi Kuwabara, Yasunori Sato, Nobuko Yamaguchi, Kengo Nagashima, Kanako Katayama, Yukari Sekiguchi, Yuta Iwai, Hiroshi Amino, Tomoki Suichi, Takanori Yokota, Yoichiro Nishida, Tadashi Kanouchi, Nobuo Kohara, Michi Kawamoto, Junko Ishii, Motoi Kuwahara, Hidekazu Suzuki, Koichi Hirata, Norito Kokubun, Ray Masuda, Juntaro Kaneko, Ichiro Yabe, Hidenao Sasaki, Ken-Ichi Kaida, Hiroshi Takazaki, Norihiro Suzuki, Shigeaki Suzuki, Hiroyuki Nodera, Naoko Matsui, Shoji Tsuji, Haruki Koike, Ryo Yamasaki, Susumu Kusunoki
BACKGROUND: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of eculizumab, a humanised monoclonal antibody against the complement protein C5, in patients with severe Guillain-Barré syndrome. METHODS: This study was a 24 week, multicentre, double-blind, placebo-controlled, randomised phase 2 trial done at 13 hospitals in Japan...
April 20, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29681203/the-immunotherapy-of-guillain-barr%C3%A3-syndrome
#4
Paula Restrepo-Jiménez, Yhojan Rodríguez, Paulina González, Christopher Chang, M Eric Gershwin, Juan-Manuel Anaya
Guillain-Barré syndrome is the most common cause of acute flaccid paralysis worldwide. Microorganisms such as Campylobacter jejuni, Cytomegalovirus, Epstein-Barr virus, Mycoplasma pneumoniae, Haemophilus influenza and Zika virus have been linked to the disease. The most common clinical variants are acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. Plasma exchange and intravenous immunoglobulins are the standard therapy for the disease. Areas covered: research to elucidate the pathophysiology of Guillain-Barré syndrome has led to the development of drugs directed towards new potential therapeutic targets...
April 23, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29675091/cranial-nerve-involvement-in-guillain-barre-syndrome-revisited
#5
Khichar Purnaram Shubhakaran
No abstract text is available yet for this article.
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29669602/cerebral-vasculitis-and-lateral-rectus-palsy-two-rare-central-nervous-system-complications-of-dengue-fever-two-case-reports-and-review-of-the-literature
#6
H M M Herath, J S Hewavithana, C M De Silva, O A R Kularathna, N P Weerasinghe
BACKGROUND: Dengue fever is a common mosquito-borne viral illness with a clinical spectrum ranging from a simple febrile illness to potentially life-threatening complications such as dengue hemorrhagic fever and dengue shock syndrome. Dengue infection can affect many organs, including the central nervous system. The neurological manifestations reported in dengue infections are meningitis, encephalitis, stroke, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. CASE PRESENTATION: We report the cases of two interesting patients with confirmed dengue infection who presented with complications of possible central nervous system vasculitis and cranial nerve palsy...
April 19, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29668332/neurological-complications-of-zika-virus-infection
#7
Francisco Javier Carod-Artal
Zika virus (ZIKV) disease is a vector-borne infectious disease transmitted by Aedes mosquitoes. Recently, ZIKV has caused outbreaks in most American countries. Areas covered: Publications about neurological complications of ZIKV infection retrieved from pubmed searchers were reviewed, and reference lists and relevant articles from review articles were also examined. Vertical/intrauterine transmission leads to congenital infection and causes microcephaly and congenital ZIKV syndrome. ZIKV preferentially infects human neural progenitor cells and triggers cell apoptosis...
April 18, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29665882/effects-of-antibiotic-resistance-ar-and-microbiota-shifts-on-campylobacter-jejuni-mediated-diseases
#8
Phillip T Brooks, Linda S Mansfield
Campylobacter jejuni is an important zoonotic pathogen recently designated a serious antimicrobial resistant (AR) threat. While most patients with C. jejuni experience hemorrhagic colitis, serious autoimmune conditions can follow including inflammatory bowel disease (IBD) and the acute neuropathy Guillain Barré Syndrome (GBS). This review examines inter-relationships among factors mediating C. jejuni diarrheal versus autoimmune disease especially AR C. jejuni and microbiome shifts. Because both susceptible and AR C...
December 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29665426/human-papillomavirus-vaccine-and-demyelinating-diseases-a-systematic-review-and-meta-analysis
#9
Julie Mouchet, Francesco Salvo, Emanuel Raschi, Elisabetta Poluzzi, Ippazio Cosimo Antonazzo, Fabrizio De Ponti, Bernard Bégaud
BACKGROUND: Approved in 2006, human papillomavirus (HPV) vaccines were initially targeted for girls aged 9-14 years. Although the safety of these vaccines has been monitored through post-licensure surveillance programmes, cases of neurological events have been reported worldwide. PURPOSE: The present study aimed to assess the risk of developing demyelination after HPV immunization by meta-analysing risk estimates from pharmacoepidemiologic studies. DATA SOURCES: A systematic review was conducted in Medline, Embase, ISI Web of Science and the Cochrane Library from inception to 10 May 2017, without language restriction...
April 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29663680/knowledge-gaps-in-control-of-campylobacter-for-prevention-of-campylobacteriosis
#10
I Hansson, M Sandberg, I Habib, R Lowman, E O Engvall
Campylobacteriosis is an important, worldwide public health problem with numerous socio-economic impacts. Since 2015, approximately 230,000 cases have been reported annually in Europe. In the United States, Australia and New Zealand, campylobacteriosis is the most commonly reported disease. Poultry and poultry products are considered important sources of human infections. Poultry meat can become contaminated with Campylobacter during slaughter if live chickens are intestinal carriers. Campylobacter spp. can be transferred from animals to humans through consumption and handling of contaminated food products, with fresh chicken meat being the most commonly implicated food type...
April 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29659541/zika-virus-in-the-male-reproductive-tract
#11
REVIEW
Liesel Stassen, Charles W Armitage, David J van der Heide, Kenneth W Beagley, Francesca D Frentiu
Arthropod-borne viruses (arboviruses) are resurging across the globe. Zika virus (ZIKV) has caused significant concern in recent years because it can lead to congenital malformations in babies and Guillain-Barré syndrome in adults. Unlike other arboviruses, ZIKV can be sexually transmitted and may persist in the male reproductive tract. There is limited information regarding the impact of ZIKV on male reproductive health and fertility. Understanding the mechanisms that underlie persistent ZIKV infections in men is critical to developing effective vaccines and therapies...
April 16, 2018: Viruses
https://www.readbyqxmd.com/read/29652304/-approach-for-identifying-of-treatment-option-for-pediatric-patients-in-guillain-barre-syndrome-considering-results-of-pharmacoeconomic-analysis
#12
A K Shakaryan, A V Rakhteenko, R I Yagudina, A Yu Kulikov, V G Serpik, I V Mitrofanova
AIM: A pharmacoeconomic analysis of direct costs on treatment with high dose intravenous immunoglobulins (IVIG) and plasmapheresis (PP) in children. MATERIAL AND METHODS: Literature data on the pathogenesis of Guillain-Barre syndrome (GBS) were analyzed. The results of pharmacoeconomic analysis of direct costs on treatment of GBS using IVIG and PP are presented. Risks for complications during treatment with IVIG and PP are calculated. RESULTS AND CONCLUSION: The pharmacoeconomic analysis demonstrates comparable costs of treatment with IVIG or PP in the Russian Federation...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29627773/clinical-outcome-of-guillain-barr%C3%A3-syndrome-after-prolonged-mechanical-ventilation
#13
Bianca van den Berg, Eline F Storm, Marcel J P Garssen, Patricia H Blomkwist-Markens, Bart C Jacobs
BACKGROUND: Patients with Guillain-Barré syndrome (GBS) may suffer from respiratory failure for months or longer. The aim of this study was to determine the frequency, clinical course and outcome of patients with GBS requiring prolonged mechanical ventilation (MV). METHODS: Prospectively collected data from 526 patients with GBS participating in previous trials were analysed to determine the frequency and duration of prolonged MV (longer than 2 months). In addition, a cross-sectional study was conducted in patients with GBS requiring MV to determine the clinical course and long-term outcome with the ability to walk unaided as primary endpoint...
April 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29627532/effector-memory-cd8-t-cells-synergize-with-co-stimulation-competent-macrophages-to-trigger-autoimmune-peripheral-neuropathy
#14
Mu Yang, Xiang Qun Shi, Corentin Peyret, Oladayo Oladiran, Sonia Wu, Julien Chambon, Sylvie Fournier, Ji Zhang
Autoimmune peripheral neuropathy (APN) such as Guillain Barre Syndrome (GBS) is a debilitating illness and sometimes life threatening. The molecular and cellular mechanisms remain elusive but exposure to environmental factors including viral/bacterial infection and injury is highly associated with disease incidence. We demonstrated previously that both male and female B7.2 (CD86) transgenic L31 and L31/CD4KO mice develop spontaneous APN. Here we further reveal that CD8+ T cells in these mice exhibit an effector/memory phenotype, which bears a resemblance to CD8+ T cell response following persistent cytomegalovirus (CMV) infection in humans and mice, whilst CMV has been considered as one of the most relevant pathogens in APN development...
April 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29624819/use-of-s17-fragment-containing-hepatitis-e-virus-infectious-clones-in-cell-culture-experiments-the-fine-print-does-matter
#15
Siddharth Sridhar
I read with interest the work by Drave et al on the replication of hepatitis E virus (HEV) in neuronal cell lines (1). HEV is increasingly associated with a range of neurological manifestations including Guillain Barre Syndrome, neuralgic amyotrophy and encephalitis (2). Therefore, in-vitro work on this subject is timely and important. This article is protected by copyright. All rights reserved.
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29624650/neurofilament-light-protein-levels-in-cerebrospinal-fluid-predict-long-term-disability-of-guillain-barr%C3%A3-syndrome-a-pilot-study
#16
M Axelsson, M Sjögren, O Andersen, K Blennow, H Zetterberg, J Lycke
OBJECTIVES: Although the recovery from Guillain-Barré syndrome (GBS) is good in most patients, some develop permanent severe disability or even die. Early predictors would increase the likelihood to identify patients at risk for poor outcome at the acute stage, allowing them intensified therapeutic intervention. MATERIALS AND METHOD: Eighteen patients with a history of GBS 9-17 years ago were reassessed with scoring of neurological disability and quality of life assessment (QoL)...
April 6, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29623081/a-new-in-vivo-model-to-study-protective-immunity-to-zika-virus-infection-in-mice-with-intact-type-i-interferon-signaling
#17
Loulieta Nazerai, Amalie Skak Schøller, Peter Overbeck Sharma Rasmussen, Søren Buus, Anette Stryhn, Jan Pravsgaard Christensen, Allan Randrup Thomsen
The association between recent Zika virus (ZIKV) infection and neurological complications, microcephaly in the fetus, and Guillain-Barré syndrome in adults underscores the necessity for a protective vaccine. Rational vaccine development requires an in-depth understanding of the mechanisms which could protect against infection with this virus. However, so far, such an analysis has been hampered by the absence of a suitable small animal model. Unlike the situation in humans, ZIKV only replicates effectively in the peripheral organs of mice, if type I IFN signaling is interrupted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29615760/human-sertoli-cells-support-high-levels-of-zika-virus-replication-and-persistence
#18
Anil Kumar, Juan Jovel, Joaquin Lopez-Orozco, Daniel Limonta, Adriana M Airo, Shangmei Hou, Iryna Stryapunina, Chad Fibke, Ronald B Moore, Tom C Hobman
Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using primary cell cultures, we observed that Sertoli but not Leydig cells are highly susceptible to Zika virus infection, a process that is dependent on the TAM family receptor Axl. In cell culture, Sertoli cells could be productively infected with Zika virus for at least 6-weeks...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29613895/infectious-myelopathies
#19
Marie F Grill
PURPOSE OF REVIEW: This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former. RECENT FINDINGS: Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections)...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29601870/anti-gm1-ganglioside-antibodies-modulate-membrane-associated-sphingomyelin-metabolism-by-altering-neutral-sphingomyelinase-activity
#20
Akihiro Ueda, Sayuri Shima, Kenitiroh Murate, Kouichi Kikuchi, Ryunosuke Nagao, Toshiki Maeda, Eri Muto, Yoshiki Niimi, Yasuaki Mizutani, Tatsuro Mutoh
Previous studies have shown that patients with Guillain-Barré syndrome express autoantibodies against ganglioside GM1 (GM1), although its pathogenic significance for the development of the disease remains to be elucidated. nSMase2 is the best characterized neutral sphingomyelinase (nSMase) found in neuronal cells. Activation of this enzyme leads to ceramide production, which is a known second messenger of the cell-death program in neuronal cells. We have explored the effects of anti-GM1 antibodies on sphingomyelin metabolism of PC12 cells stably transfected with human trk cDNA (PCtrk cells) by determining their effects on nSMase2 activity...
March 27, 2018: Molecular and Cellular Neurosciences
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