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https://www.readbyqxmd.com/read/29245058/quantitative-eeg-power-and-synchronization-correlate-with-alzheimer-s-disease-csf-biomarkers
#1
Una Smailovic, Thomas Koenig, Ingemar Kåreholt, Thomas Andersson, Milica Gregoric Kramberger, Bengt Winblad, Vesna Jelic
Synaptic dysfunction is the best anatomical correlate of early cognitive impairment in Alzheimer's disease (AD). Electroencephalography (EEG) directly reflects brain electrical activity at the level of synapses. The aim of the present study was to investigate correlations of quantitative EEG measures, global field power (GFP) and global field synchronization (GFS), with conventional cerebrospinal fluid (CSF) biomarkers of neurodegeneration in patients diagnosed with subjective cognitive decline (n = 210), mild cognitive impairment (n = 230), and AD (n = 197)...
November 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29245023/mild-cognitive-impairment-what-does-the-general-public-know-about-this-health-condition
#2
R Alhasani, J Abed, N Karegar, E Redmond, Y Guo, G Wasserlauf, D Goldberg, C Kwok, N Bier, P Belchior
No abstract text is available yet for this article.
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29244786/functional-assessment-as-a-predictor-of-cognitive-impairment-a-retrospective-cohort-study
#3
Gustavo Alberto Sandival Ampuero, Fernando M Runzer-Colmenares, José F Parodi
INTRODUCTION: It is estimated that major neurocognitive disorders will affect 115.4 million people by 2050, representing a significant financial burden for society. Likewise, functional dependence for basic or instrumental activities of daily life is usually a consequence of the greater prevalence of disabling pathologies, and of the progressive decrease of the physiological reserve due to aging. OBJECTIVES: To determine the ratio between the functional test and prediction of deterioration of cognitive function in geriatric patients...
December 12, 2017: Medwave
https://www.readbyqxmd.com/read/29244265/herpes-zoster-and-dementia-a-nationwide-population-based-cohort-study
#4
Vincent Chin-Hung Chen, Shu-I Wu, Kuo-You Huang, Yao-Hsu Yang, Ting-Yu Kuo, Hsin-Yi Liang, Kuan-Lun Huang, Michael Gossop
OBJECTIVE: Some infectious diseases have been found to be associated with cognitive impairment and dementia. However, the relationship between herpes zoster and dementia has received little attention. This study aimed to investigate this association as well as associations of antiviral treatments for herpes zoster and incident dementia using a large national sample. METHODS: Cases were identified from the Taiwan National Health Insurance Research Database with a new diagnosis of herpes zoster (ICD-9-CM code: 053) between 1997 and 2013...
December 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29244170/sleep-deprivation-triggers-cognitive-control-impairments-in-task-goal-switching
#5
Hichem Slama, Daphne Olivia Chylinski, Gaétane Deliens, Rachel Leproult, Rémy Schmitz, Philippe Peigneux
Study objectives: This study investigates the impact of sleep deprivation (SD) on task-goal switching, a key component of cognitive flexibility. Methods: Task-goal switching performance was tested after one night of regular sleep (n = 17 participants) or of total SD (n = 18). To understand the relationships between task-switching performance and other cognitive processes following SD, participants were tested for other key attentional (alertness and vigilance) and executive (inhibition and working memory) functions...
December 13, 2017: Sleep
https://www.readbyqxmd.com/read/29244126/silent-cerebral-small-vessel-disease-twice-as-prevalent-in-middle-aged-well-controlled-cart-treated-hiv-infected-individuals-than-hiv-uninfected-individuals
#6
Antoine Moulignier, Julien Savatovsky, Lambert Assoumou, François-Xavier Lescure, Cédric Lamirel, Ophelia Godin, Nadia Valin, Roland Tubiana, Ana Canestri, Pascal Roux, Jean-Claude Sadik, Laurence Salomon, Marie Abrivard, Christine Katlama, Yazdan Yazdanpanah, Gilles Pialoux, Pierre-Marie Girard, Dominique Costagliola
Background: Silent cerebral small-vessel disease (CSVD) is defined as white matter hyperintensities, silent brain infarction or microbleeds. CSVD is responsible for future vascular events, cognitive impairment, frailty and shorter survival. CSVD prevalence among middle-aged persons living with well-controlled HIV infection (PLHIVs) is unknown. Methods: ANRS EP51 MicroBREAK (NCT02082574) is a cross-sectional study with prospective enrollment of treated PLHIVs, ≥50 years old with viral load controlled for ≥12 months, and frequency age- and sex-matched HIV-uninfected controls (HUCs)...
December 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29244090/prevalence-and-risk-of-severe-cognitive-impairment-in-advanced-chronic-kidney-disease
#7
Christine M Burns, David S Knopman, David E Tupper, Cynthia S Davey, Yelena M Slinin, Kamakshi Lakshminarayan, Rebecca C Rossom, Sarah L Pederson, David T Gilbertson, Anne M Murray
Background: Our primary goal is to describe the prevalence, severity, and risk of cognitive impairment (CI) by estimated glomerular filtration rate (eGFR, in ml/min/1.73 m 2) in a cohort enriched for advanced CKD (eGFR < 45), adjusting for albuminuria, as measured by urine albumin-to-creatinine ratio (UACR, in mg/g). As both eGFR and albuminuria are associated with CI risk in CKD, we also seek to determine the extent that eGFR remains a useful biomarker for risk of CI in those with CKD and concomitant albuminuria...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29244089/the-historical-progression-from-adl-scrutiny-to-iadl-to-advanced-adl-assessing-functional-status-in-the-earliest-stages-of-dementia
#8
Robert Fieo, Laura Zahodne, Ming X Tang, Jennifer J Manly, Ron Cohen, Yaakov Stern
Background: Decrements in instrumental activities (IADL) have been observed in the prodromal phase of dementia. Given the long pre-dementia stage in neuro-degenerative diseases, it has been proposed that subtle functional changes may precede clinical IADL impairment. Incorporating more challenging advanced ADLs (e.g., volunteer work) into the assessment process may increase the sensitivity of functional measures, thus expanding the window for monitoring or interventions. Methods: Longitudinal cohort study (follow-ups, 18-24 month), subjects aged >60 (n=3635)...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29244062/longitudinal-course-and-predictors-of-apathetic-symptoms-after-severe-traumatic-brain-injury
#9
Annabelle Arnould, Lucien Rochat, Philippe Azouvi, Martial Van der Linden
Objectives: Apathy is one of the most common behavioral symptoms encountered after traumatic brain injury (TBI). However, very little is known about the longitudinal course and predictors of apathetic manifestations. The aims of the present study were to examine how apathy changes and the predictive value of cognitive factors (memory, attention/executive mechanisms, and multitasking) and personal identity factors (self-esteem and self-efficacy beliefs) for apathy over a period of 10 months...
December 13, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29244060/the-residual-medium-and-long-term-cognitive-effects-of-benzodiazepine-use-an-updated-meta-analysis
#10
Simon F Crowe, Elizabeth K Stranks
Objective: This study presents an updated meta-analysis of the effects of benzodiazepines on cognitive functioning in long-term, current users of these agents, those who have recently withdrawn and on those who have successfully abstained following withdrawal. The study represents an update of the previous meta-analyses published by our group. Method: A comprehensive search of the computerized databases Medline and PsycINFO was undertaken to identify studies that assessed the cognitive effects of benzodiazepines published up to 28 November 2016 (the date of the last update)...
December 13, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29244058/antidepressant-use-and-cognitive-outcomes-in-very-old-women
#11
Yue Leng, Susan J Diem, Katie L Stone, Kristine Yaffe
Background: Antidepressant use is very common in the elderly, but the effects of antidepressants on cognition in the elderly are controversial with some studies suggesting harm and others protection. We aimed to investigate the association between different antidepressant use and change in cognition and risk of mild cognitive impairment (MCI) or dementia in very old women. Methods: We examined 1,234 community-dwelling women (mean age 83.2 years) from the Study of Osteoporotic Fractures...
December 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29244054/a-systematic-review-for-functional-neuroimaging-studies-of-cognitive-reserve-across-the-cognitive-aging-spectrum
#12
Mia Anthony, Feng Lin
Objective: Cognitive reserve has been proposed to explain the discrepancy between clinical symptoms and the effects of aging or Alzheimer's pathology. Functional magnetic resonance imaging (fMRI) may help elucidate how neural reserve and compensation delay cognitive decline and identify brain regions associated with cognitive reserve. This systematic review evaluated neural correlates of cognitive reserve via fMRI (resting-state and task-related) studies across the cognitive aging spectrum (i...
December 13, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29243873/a-comprehensive-review-of-genetic-and-epigenetic-mechanisms-that-regulate-bdnf-expression-and-function-with-relevance-to-major-depressive-disorder
#13
REVIEW
Benjamin Hing, Leela Sathyaputri, James B Potash
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs cognition. A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is involved in processes controlling neuroplasticity. Various mechanisms exist to regulate BDNF's expression level, subcellular localization, and sorting to appropriate secretory pathways. Alterations to these processes by genetic factors and negative stressors can dysregulate its expression, with possible implications for MDD...
December 15, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29243792/analysis-of-correlation-between-the-mild-cognitive-impairment-mci-and-level-of-adiponectin-in-elderly-patients-with-type-2-diabetes-mellitus-t2dm
#14
Z-Q Liu, M-X Zhang, J Wang, N Ding
OBJECTIVE: To investigate the correlation between the mild cognitive impairment (MCI) and serum level of adiponectin in elderly patients with Type II diabetes mellitus (T2DM), so as to provide evidence for early diagnosis of MCI and effective evaluation of the impairment of cognitive functions, thereby preventing the impairment of cognitive function as early as possible. PATIENTS AND METHODS: Clinical data were collected from 260 T2DM patients (≥ 60 years old) in Endocrine Department and 120 healthy subjects (≥ 60 years old) who underwent physical examination in our hospital between June 2015 and June 2017...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243783/research-on-the-nutrition-and-cognition-of-high-risk-stroke-groups-in-community-and-the-relevant-factors
#15
N-N Zhao, K-X Zeng, Y-L Wang, P-J Sheng, C-Z Tang, P Xiao, X-W Liu
OBJECTIVE: To investigate the prevalence rate of nutritional risk in high-risk stroke groups in community, analyze its influencing factors, and analyze and compare the relationship between nutritional risk or malnutrition assessed by different nutritional evaluation methods and cognitive function, so as to provide the basis and guidance for clinical nutritional assessment and support. PATIENTS AND METHODS: A cross-sectional survey was performed for 1196 cases in high-risk stroke groups in community from December 2015 to January 2017...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243531/impact-of-reward-and-loss-anticipation-on-cognitive-control-an-event-related-potential-study-in-subjects-with-schizophrenia-and-healthy-controls
#16
Annarita Vignapiano, Armida Mucci, Eleonora Merlotti, Giulia Maria Giordano, Antonella Amodio, Davide Palumbo, Silvana Galderisi
INTRODUCTION: Deficits of cognitive functions and motivation are core aspects of schizophrenia. The interaction of these deficits might contribute to impair the ability to flexibly adjust behavior in accordance with one's intentions and goals. Many studies have focused on the anterior N2 as a correlate of cognitive control based on motivational value. AIMS: Given the key role of motivation impairment in schizophrenia as a predictor of functional outcome, we aimed to study the impact of reward- and avoidance-based motivation on cognitive control using N2...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29243529/avolition-apathy-and-white-matter-connectivity-in-schizophrenia-reduced-fractional-anisotropy-between-amygdala-and-insular-cortex
#17
Antonella Amodio, Mario Quarantelli, Armida Mucci, Anna Prinster, Andrea Soricelli, Annarita Vignapiano, Giulia Maria Giordano, Eleonora Merlotti, Alessia Nicita, Silvana Galderisi
The avolition/apathy domain of negative symptoms includes motivation- and pleasure-related impairments. In people with schizophrenia, structural and functional abnormalities were reported in key regions within the motivational reward system, including ventral-tegmental area (VTA), striatum (especially at the level of the nucleus accumbens, NAcc), orbitofrontal cortex (OFC), as well as amygdala (Amy) and insular cortex (IC). However, the association of the reported abnormalities with avoliton-apathy is still controversial...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29243370/neurological-nutritional-and-alcohol-consumption-factors-underlie-cognitive-and-motor-deficits-in-chronic-alcoholism
#18
Rosemary Fama, Anne-Pascale Le Berre, Cheshire Hardcastle, Stephanie A Sassoon, Adolf Pfefferbaum, Edith V Sullivan, Natalie M Zahr
Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impairment. Participants with ALC (n = 96) and a normal comparison group (n = 41) were examined on six cognitive and motor domains. Signs of historically determined subclinical Wernicke's encephalopathy were detected using the Caine et al...
December 15, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29243202/non-invasive-cerebellar-stimulation-a-promising-approach-for-stroke-recovery
#19
REVIEW
Maximilian J Wessel, Friedhelm C Hummel
Non-invasive brain stimulation (NIBS) combined with behavioral training is a promising strategy to augment recovery after stroke. Current research efforts have been mainly focusing on primary motor cortex (M1) stimulation. However, the translation from proof-of-principle to clinical applications is not yet satisfactory. Possible reasons are the heterogeneous properties of stroke, generalization of the stimulation protocols, and hence the lack of patient stratification. One strategy to overcome these limitations could be the evaluation of alternative stimulation targets, like the cerebellum...
December 14, 2017: Cerebellum
https://www.readbyqxmd.com/read/29243191/pharmacologically-induced-impairment-of-neurovascular-coupling-responses-alters-gait-coordination-in-mice
#20
Stefano Tarantini, Andriy Yabluchanksiy, Gábor A Fülöp, Peter Hertelendy, M Noa Valcarcel-Ares, Tamas Kiss, Jonathan M Bagwell, Daniel O'Connor, Eszter Farkas, Farzaneh Sorond, Anna Csiszar, Zoltan Ungvari
There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with alterations in gait and development of falls in elderly people. CBF is adjusted to neuronal activity via neurovascular coupling (NVC) and this mechanism becomes progressively impaired with age. To establish a direct cause-and-effect relationship between impaired NVC and gait abnormalities, we induced neurovascular uncoupling pharmacologically in young C57BL/6 mice by inhibiting the synthesis of vasodilator mediators involved in NVC...
December 14, 2017: GeroScience
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