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https://www.readbyqxmd.com/read/27045885/co-expression-of-mouse-tmem63a-tmem63b-and-tmem63c-confers-hyperosmolarity-activated-ion-currents-in-hek293-cells
#1
Xin Zhao, Xiaojuan Yan, Yuanhu Liu, Ping Zhang, Xin Ni
Osmoreception is essential for systemic osmoregulation, a process to stabilize the tonicity and volume of the extracellular fluid through regulating the ingestive behaviour, sympathetic outflow and renal function. The sensation of osmotic changes by osmoreceptor neurons is mediated by ion channels that detect the change of osmolarity in extracellular fluid. However, the molecular identity of these channels remains mysterious. AtCSC1and OSCA1,two closely related paralogues from Arabidopsis, have been demonstrated to form hyperosmolarity activated ion channels, which makes their mammalian orthologues-the members of TMEM63 proteins, possible candidates for osmoreceptor transduction channel...
June 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/23037145/association-of-genes-on-chromosome-6-grik2-tmem217-and-tmem63b-linked-to-mrpl14-with-diabetic-retinopathy
#2
COMPARATIVE STUDY
Hui-Ju Lin, Yu-Chuen Huang, Jane-Ming Lin, Jer-Yuarn Wu, Liuh-An Chen, Fuu-Jen Tsai
PURPOSE: Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM). The susceptibility genes responsible for increasing the risk for DR in type 2 diabetes (T2D) were sought in this study. METHODS: A case-control study was carried out, comprising 749 unrelated T2D individuals with (n = 174) and without (n = 575) DR. Genotypic distributions of single nucleotide polymorphisms (SNPs) were determined for subjects with and without DR...
2013: Ophthalmologica. Journal International D'ophtalmologie
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