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https://www.readbyqxmd.com/read/29664240/polymorphisms-of-dna-repair-genes-are-associated-with-colorectal-cancer-in-patients-with-lynch-syndrome
#1
Abram B Kamiza, Ling-Ling Hsieh, Reiping Tang, Huei-Tzu Chien, Chih-Hsiung Lai, Li-Ling Chiu, Tsai-Ping Lo, Kuan-Yi Hung, Jeng-Fu You, Wen-Chang Wang, Chao A Hsiung, Chih-Ching Yeh
BACKGROUND: DNA repair genes are crucial for maintaining genomic stability by preventing mutagenesis and carcinogenesis. The present retrospective cohort study aimed at investigating whether MLH1, APEX1, MUTYH, OGG1, NUDT1, XRCC5, XPA, and ERCC2 single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in Chinese population with Lynch syndrome. METHODS: From Amsterdam criteria family registry, we identified 270 patients with Lynch syndrome...
April 17, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29643057/defective-base-excision-repair-of-oxidative-dna-damage-in-vascular-smooth-muscle-cells-promotes-atherosclerosis
#2
Aarti Shah, Kelly Gray, Nichola Figg, Alison Finigan, Lakshi Starks, Martin Bennett
Background -Atherosclerotic plaques demonstrate extensive accumulation of oxidative DNA damage, predominantly as 8-oxoguanine (8oxoG) lesions. 8oxoG is repaired by base excision repair (BER) enzymes; however, the mechanisms regulating 8oxoG accumulation in vascular smooth muscle cells (VSMCs) and its effects on their function and in atherosclerosis are unknown. Methods -We studied levels of 8oxoG and its regulatory enzymes in human atherosclerosis, the mechanisms regulating 8oxoG repair and the BER enzyme 8oxoG DNA glycosylase I (OGG1) in VSMCs in vitro, and the effects of reducing 8oxoG in VSMCs in atherosclerosis in ApoE-/- mice...
April 11, 2018: Circulation
https://www.readbyqxmd.com/read/29626765/oxidatively-induced-dna-damage-and-base-excision-repair-in-euthymic-patients-with-bipolar-disorder
#3
Deniz Ceylan, Gamze Tuna, Güldal Kirkali, Zeliha Tunca, Güneş Can, Hidayet Ece Arat, Melis Kant, Miral Dizdaroglu, Ayşegül Özerdem
Oxidatively-induced DNA damage has previously been associated with bipolar disorder. More recently, impairments in DNA repair mechanisms have also been reported. We aimed to investigate oxidatively-induced DNA lesions and expression of DNA glycosylases involved in base excision repair in euthymic patients with bipolar disorder compared to healthy individuals. DNA base lesions including both base and nucleoside modifications were measured using gas chromatography-tandem mass spectrometry and liquid chromatography-tandem mass spectrometry with isotope-dilution in DNA samples isolated from leukocytes of euthymic patients with bipolar disorder (n = 32) and healthy individuals (n = 51)...
March 30, 2018: DNA Repair
https://www.readbyqxmd.com/read/29615218/placental-promoter-methylation-of-dna-repair-genes-and-prenatal-exposure-to-particulate-air-pollution-an-environage-cohort-study
#4
Kristof Y Neven, Nelly D Saenen, Letitzia Tarantini, Bram G Janssen, Wouter Lefebvre, Charlotte Vanpoucke, Valentina Bollati, Tim S Nawrot
BACKGROUND: Exposure to particulate air pollution has been linked with risk of carcinogenesis. Damage to repair pathways might have long-term adverse health effects. We aimed to investigate the association of prenatal exposure to air pollution with placental mutation rate and the DNA methylation of key placental DNA repair genes. METHODS: This cohort study used data from the ongoing ENVironmental Influence ON early AGEing (ENVIRONAGE) birth cohort, which enrols pairs of mothers and neonates (singleton births only) at the East-Limburg Hospital (Genk, Belgium)...
April 2018: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29581776/association-of-smoking-and-xpg-cyp1a1-ogg1-ercc5-ercc1-mmp2-and-mmp9-gene-polymorphisms-with-the-early-detection-and-occurrence-of-laryngeal-squamous-carcinoma
#5
Yi Zhu, Luo Guo, ShengZi Wang, Qun Yu, JianXiong Lu
A total of 200 smoking-related laryngeal carcinoma patients with pathology confirmation from the Eye and ENT Hospital and 190 high-risk smokers were included in a survey. All of the participants had a smoking index greater than 400 (cigarettes/day*year.) We obtained data on clinical and baseline characteristics, and peripheral blood was obtained and subjected to DNA extraction to analyse the correlation between smoking and the occurrence of laryngeal carcinoma. We selected candidate genes and SNP fragments that were found to be closely associated with smoking-related tumours in preliminary studies...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29554508/biological-response-of-zebrafish-after-short-term-exposure-to-azoxystrobin
#6
Jinhua Jiang, Yan Shi, Ruixian Yu, Liping Chen, Xueping Zhao
Azoxystrobin (AZ) is a broad-spectrum systemic fungicide that widely used in the world. The present study investigated the toxicity effects on zebrafish after short-term exposure of AZ. Results demonstrated that the larval stage was most susceptible to AZ in the multiple life stages of zebrafish, with 96 h-LC50 value of 0.777 mg/L. Zebrafish larvae were exposed to different AZ concentrations (0, 0.1, 1, 10, 100 μg/L) and examined on 24, 48 and 72 h. It was found that AZ induced ROS accumulation, increased GST, GPX and POD activity and the transcriptions of antioxidant and stress response related genes, while the opposite trend occurred for SOD and CAT activity in 24-h or 48-h exposure period...
March 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29540303/epigenetic-modulation-of-nrf2-and-ogg1-gene-expression-in-testicular-germ-cells-by-methyl-parathion-exposure
#7
D Hernandez-Cortes, I Alvarado-Cruz, M J Solís-Heredia, B Quintanilla-Vega
Methyl parathion (Me-Pa) is an oxidizing organophosphate (OP) pesticide that generates reactive oxygen species (ROS) through its biotransformation. Some studies have also suggested that OP pesticides have the capacity to alkylate biomolecules, including DNA. In general, DNA methylation in gene promoters represses transcription. NRF2 is a key transcription factor that regulates the expression of antioxidant, metabolic and detoxifying genes through the antioxidant response element (ARE) situated in promoters of regulated genes...
March 11, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29516665/the-polymorphisms-of-mirna-binding-site-in-mlh3-and-ercc1-were-linked-to-the-risk-of-colorectal-cancer-in-a-case-control-study
#8
Qianye Zhang, Xiao Zheng, Xiaoxia Li, Deyu Sun, Ping Xue, Guopei Zhang, Mingyang Xiao, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo Lu
Colorectal cancer (CRC), as a malignant tumor of lower digestive tract, has been found to have an increasing morbidity and mortality in China. It was particularly important to find some earlier biomarkers to predict the risk and prognosis. In this study, several polymorphisms on 3'UTR of three DNA repair genes including MLH3 rs10862, ERCC1 rs3212986, ERCC1 rs735482, ERCC1 rs2336219, and OGG1 rs1052133 were chosen by bioinformatics exploration, and then, a case-control study of 200 CRC cases and controls was performed...
March 8, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29496532/deficiency-in-the-dna-glycosylases-ung1-and-ogg1-does-not-potentiate-c-myc-induced-b-cell-lymphomagenesis
#9
Blerta Green, Alberto Martin, Antoaneta Belcheva
C-Myc overexpression mediates lymphomagenesis, however, secondary genetic lesions are required for its full oncogenic potential. The origin and the mechanism of formation of these mutations are unclear. Using the lacI-mutation detection system, we show that secondary mutations occur early in B-cell development and are repaired by Msh2. The mutations at the lacI gene were predominantly at C:G base pairs and CpG motifs suggesting that they were formed due to cytosine deamination or oxidative damage of G. Hence, we investigated the role of Ogg1 and UNG glycosylases in c-Myc driven lymphomagenesis but found that their deficiencies did not influence the disease outcome in the Eµ c-Myc mouse model...
February 26, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29475157/the-role-of-the-n-terminal-domain-of-human-apurinic-apyrimidinic-endonuclease-1-ape1-in-dna-glycosylase-stimulation
#10
Olga A Kladova, Milena Bazlekowa-Karaban, Sonia Baconnais, Olivier Piétrement, Alexander A Ishchenko, Bakhyt T Matkarimov, Danila A Iakovlev, Andrey Vasenko, Olga S Fedorova, Eric Le Cam, Barbara Tudek, Nikita A Kuznetsov, Murat Saparbaev
The base excision repair (BER) pathway consists of sequential action of DNA glycosylase and apurinic/apyrimidinic (AP) endonuclease necessary to remove a damaged base and generate a single-strand break in duplex DNA. Human multifunctional AP endonuclease 1 (APE1, a.k.a. APEX1, HAP-1, or Ref-1) plays essential roles in BER by acting downstream of DNA glycosylases to incise a DNA duplex at AP sites and remove 3'-blocking sugar moieties at DNA strand breaks. Human 8-oxoguanine-DNA glycosylase (OGG1), methyl-CpG-binding domain 4 (MBD4, a...
February 11, 2018: DNA Repair
https://www.readbyqxmd.com/read/29471131/aerobic-and-strength-training-induce-changes-in-oxidative-stress-parameters-and-elicit-modifications-of-various-cellular-components-in-skeletal-muscle-of-aged-rats
#11
Thais Ceresér Vilela, Pauline Souza Effting, Giulia Dos Santos Pedroso, Hemelin Farias, Lara Paganini, Helen Sorato Rebelo, Renata Tiescoski Nesi, Vanessa Moraes de Andrade, Ricardo Aurino de Pinho
Skeletal muscle aging is associated with loss of mass, function, and strength-a condition known as sarcopenia. It has been reported that sarcopenia can be attenuated by physical exercise. Therefore, we investigated whether 2 different physical exercise protocols could modulate and induce changes in oxidative and inflammatory parameters, as well as in BDNF and DNA repair enzyme levels in skeletal muscle tissue of aged rats. Aging Wistar rats performed treadmill or strength training for 50 min 3 to 4 times a week for 8 weeks...
February 19, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29431562/ionizing-radiation-does-not-impair-the-mechanisms-controlling-genetic-stability-during-t-cell-receptor-gene-rearrangement-in-mice
#12
Serge M Candéias, Sylwia Kabacik, Ann-Karin Olsen, Dag M Eide, Dag A Brede, Simon Bouffler, Christophe Badie
PURPOSE: To determine whether low dose/low dose rate radiation-induced genetic instability may result from radiation-induced inactivation of mechanisms induced by the ATM-dependent DNA damage response checkpoint. To this end, we analysed the faithfulness of T cell receptor (TR) gene rearrangement by V(D)J recombination in DNA from mice exposed to a single dose of X-ray or chronically exposed to low dose rate γ radiation. MATERIALS AND METHODS: Genomic DNA obtained from the blood or the thymus of wild type or Ogg1-deficient mice exposed to low (0...
February 12, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29409673/ogg1-regulates-the-level-of-symmetric-dimethylation-of-histone-h4-arginine-3-by-interacting-with-prmt5
#13
Xiaolong Zhou, Wentao Wang, Chengtao Du, Feifei Yan, Songbai Yang, Ke He, Han Wang, Ayong Zhao
OGG1 is the first enzyme in the base excision repair pathway (BER) responsible for repairing 8-oxoguanine DNA lesions. Recent studies found that OGG1 may also be involved in epigenetic regulation. In this study, we focused on the roles of OGG1 in histone modification. First, to study the effects of OGG1 on histone modification, the protein levels of symmetric dimethylation of histone H4 arginine-3 (H4R3me2s) were determined by western blot analysis following the knockdown or overexpression of OGG1. Second, the molecular mechanisms by which OGG1 regulates H4R3me2s were assessed by co-immunoprecipitation (CO-IP) assays in mouse embryonic fibroblast (MEF) wild-type (WT) and Ogg-/- cells...
February 2, 2018: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29378943/e-cigarette-smoke-damages-dna-and-reduces-repair-activity-in-mouse-lung-heart-and-bladder-as-well-as-in-human-lung-and-bladder-cells
#14
Hyun-Wook Lee, Sung-Hyun Park, Mao-Wen Weng, Hsiang-Tsui Wang, William C Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, Moon-Shong Tang
E-cigarette smoke delivers stimulant nicotine as aerosol without tobacco or the burning process. It contains neither carcinogenic incomplete combustion byproducts nor tobacco nitrosamines, the nicotine nitrosation products. E-cigarettes are promoted as safe and have gained significant popularity. In this study, instead of detecting nitrosamines, we directly measured DNA damage induced by nitrosamines in different organs of E-cigarette smoke-exposed mice. We found mutagenic O6 -methyldeoxyguanosines and γ-hydroxy-1 ,N 2 -propano-deoxyguanosines in the lung, bladder, and heart...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29376367/potent-and-selective-inhibitors-of-8-oxoguanine-dna-glycosylase-ogg1
#15
Yu-Ki Tahara, Douglas Auld, Debin Ji, Andrew A Beharry, Anna M Kietrys, David L Wilson, Marta Jimenez, Daniel King, Zachary Nguyen, Eric T Kool
The activity of DNA repair enzyme OGG1, which excises oxidized base 8-oxoguanine (8-OG) from DNA, is closely linked to mutagenesis, genotoxicity, cancer, and inflammation. To test the roles of OGG1-mediated repair in these pathways, we have undertaken the development of noncovalent small-molecule inhibitors of the enzyme. Screening of a PubChem-annotated library using a recently developed fluorogenic 8-oxoguanine excision assay resulted in multiple validated hit structures, including selected lead hit tetrahydroquinoline 1 (IC50 = 1...
January 27, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29367705/somatic-apc-mosaicism-and-oligogenic-inheritance-in-genetically-unsolved-colorectal-adenomatous-polyposis-patients
#16
Michele Ciavarella, Sara Miccoli, Anna Prossomariti, Tommaso Pippucci, Elena Bonora, Francesco Buscherini, Flavia Palombo, Roberta Zuntini, Tiziana Balbi, Claudio Ceccarelli, Franco Bazzoli, Luigi Ricciardiello, Daniela Turchetti, Giulia Piazzi
Germline variants in the APC gene cause familial adenomatous polyposis. Inherited variants in MutYH, POLE, POLD1, NTHL1, and MSH3 genes and somatic APC mosaicism have been reported as alternative causes of polyposis. However, ~30-50% of cases of polyposis remain genetically unsolved. Thus, the aim of this study was to investigate the genetic causes of unexplained adenomatous polyposis. Eight sporadic cases with >20 adenomatous polyps by 35 years of age or >50 adenomatous polyps by 55 years of age, and no causative germline variants in APC and/or MutYH, were enrolled from a cohort of 56 subjects with adenomatous colorectal polyposis...
January 24, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29359425/mechanism-underlying-the-effect-of-long-term-exposure-to-low-dose-of-pesticides-on-dna-integrity
#17
Renata Alleva, Nicola Manzella, Simona Gaetani, Tiziana Bacchetti, Massimo Bracci, Veronica Ciarapica, Federica Monaco, Battista Borghi, Monica Amati, Gianna Ferretti, Marco Tomasetti
Pesticides, including herbicides, insecticides and fungicides, are widely used in intensive agriculture. Recently, the long-term effects of pesticide exposure were found to be associated with many diseases. In this study, we evaluated the long-term effect of low-level exposure to a mixture of pesticides on DNA damage response (DDR) in relation to individual detoxifying variability. A residential population chronically exposed to pesticides was enrolled, biological/environmental pesticide levels; paroxonase 1 (PON-1) activity and 192 Q/R polymorphism and DDR were evaluated at three different periods of pesticide exposure...
April 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29336731/lead-induces-dna-damage-and-alteration-of-alad-and-antioxidant-genes-mrna-expression-in-construction-site-workers
#18
Zertashia Akram, Sadaf Riaz, Mahmood Akhtar Kayani, Sarwat Jahan, Malik Waqar Ahmad, Muhammad Abaid Ullah, Hizbullah Wazir, Ishrat Mahjabeen
Oxidative stress and DNA damage are considered as possible mechanisms involved in lead toxicity. To test this hypothesis, DNA damage and expression variations of aminolevulinic acid dehydratase (ALAD), superoxide dismutase 2 (SOD2), and 8-oxoguanine DNA glycosylase 2a (OGG1-2a) genes was studied in a cohort of 100 exposed workers and 100 controls with comet assay and real-time polymerse chain reaction (PCR). Results indicated that increased number of comets was observed in exposed workers versus controls (p < 0...
January 16, 2018: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29306194/downregulation-of-parp1-transcription-by-cdk4-6-inhibitors-sensitizes-human-lung-cancer-cells-to-anticancer-drug-induced-death-by-impairing-ogg1-dependent-base-excision-repair
#19
Dominika Tempka, Paulina Tokarz, Kinga Chmielewska, Magdalena Kluska, Julita Pietrzak, Żaneta Rygielska, László Virág, Agnieszka Robaszkiewicz
Hallmarks of cancer cells include uncontrolled growth and rapid proliferation; thus, cyclin-dependent kinases are a therapeutic target for cancer treatment. Treating non-small lung cancer cells with sublethal concentrations of the CDK4/6 inhibitors, ribociclib (LEE011) and palbociclib (PD0332991), which are approved by the FDA for anticancer therapies, caused cell cycle arrest in the G1 phase and suppression of poly(ADP-ribose) polymerase 1 (PARP1) transcription by inducing recruitment of the RB1-E2F1-HDAC1-EZH2 repressive complex to the PARP1 promoter...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29305132/the-mediterranean-diet-the-ogg1-gene-and-disease-risk-early-evidence
#20
Nancy J Emenaker, Ashley J Vargas
No abstract text is available yet for this article.
April 2018: Journal of the Academy of Nutrition and Dietetics
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