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Delirium and cancer

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https://www.readbyqxmd.com/read/27878605/-special-medical-problems-in-end-of-life-care-crisis-at-the-end-of-life-which-therapy-is-adequate-and-when-is-redefining-treatment-goals-appropriate
#1
Gesine Benze, Bernd Alt-Epping, Friedemann Nauck
Crisis at the end of life are exceptional challenges for patients, relatives and therapists. With respect to the individual treatment goals and the patients' autonomy, therapeutic action should be commenced in an adequate manner in order to preserve the patients' quality of life as much as possible. Advance care planning for specific critical scenarios may be helpful in order to treat patients according to their wishes and values even if they are not capable to express themselves. Furthermore, a crisis plan can define the scope of action for therapists in emergency situations...
November 23, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27850844/1208-icu-delirium-adversely-impacts-early-mobilization-in-mechanically-ventilated-cancer-patients
#2
Steven Hsu, Louis Voigt, Amanda Weeks, Claudine Campbell, Maryann Herklotz, Natalie Kostelecky, Stephen Pastores, Neil Halpern
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27834803/advance-care-planning-in-glioblastoma-patients
#3
REVIEW
Lara Fritz, Linda Dirven, Jaap C Reijneveld, Johan A F Koekkoek, Anne M Stiggelbout, H Roeline W Pasman, Martin J B Taphoorn
Despite multimodal treatment with surgery, radiotherapy and chemotherapy, glioblastoma is an incurable disease with a poor prognosis. During the disease course, glioblastoma patients may experience progressive neurological deficits, symptoms of increased intracranial pressure such as drowsiness and headache, incontinence, seizures and progressive cognitive dysfunction. These patients not only have cancer, but also a progressive brain disease. This may seriously interfere with their ability to make their own decisions regarding treatment...
November 8, 2016: Cancers
https://www.readbyqxmd.com/read/27822051/production-of-inflammatory-cytokines-cortisol-and-a%C3%AE-1-40-in-elderly-oral-cancer-patients-with-postoperative-delirium
#4
Lulu Sun, Peiyu Jia, Junfeng Zhang, Xin Zhang, Yiwei Zhang, Hong Jiang, Wei Jiang, Yong Guo
AIM: Pathophysiological disorders after surgery might be related to postoperative delirium (POD). This study was designed to elucidate the pathogenesis of POD in elderly oral cancer patients by determining the perioperative kinetics of inflammatory cytokines, cortisol, and amyloid β1-40 (Aβ1-40). METHODS: A total of 257 elderly oral cancer patients who underwent tumor resection surgery were selected. Venous blood was collected prior to surgery (T0), at the end of surgery (T1), and at 12 hours after surgery (T2)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27785357/perioperative-regional-anaesthesia-and-postoperative-longer-term-outcomes
#5
REVIEW
Jan Jakobsson, Mark Z Johnson
Regional anaesthesia provides effective anaesthesia and analgesia in the perioperative setting. Central neuraxial blocks-that is, spinal and epidural blocks-are well established as an alternative or adjunct to general anaesthesia. Peripheral blocks may be used as part of multimodal anaesthesia/analgesia in perioperative practice, reducing the need for opioid analgesics and enhancing early recovery. Furthermore, regional anaesthesia has increased in popularity and may be done with improved ease and safety with the introduction of ultrasound-guided techniques...
2016: F1000Research
https://www.readbyqxmd.com/read/27773516/development-of-a-nomogram-for-predicting-the-probability-of-postoperative-delirium-in-patients-undergoing-free-flap-reconstruction-for-head-and-neck-cancer
#6
N Y Choi, E H Kim, C H Baek, I Sohn, S Yeon, M K Chung
PURPOSE: To develop nomogram for prediction of postoperative delirium (POD) in patients undergoing ablative and reconstruction surgery for head and neck cancer. METHODS: Total 341 patients were retrospectively analyzed, and clinical variables in preoperative, intraoperative and postoperative periods were compared between delirium group (n = 89) and non-delirium group (n = 252). Multivariate logistic regression, receiver operating characteristics curve, and area under the curve (AUC) were used to generate and test a nomogram, which performance was evaluated by 10-fold cross validation (CV) procedure...
October 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27676278/the-confused-oncologic-patient-a-rational-clinical-approach
#7
Craig Nolan, Lisa M DeAngelis
PURPOSE OF REVIEW: The purpose of this review is to provide a practical clinical approach to confusion in the patient with cancer. Confusion in the cancer population has a broader differential diagnosis than in the general medical population. The clinician must consider the usual differential diagnoses as well as causes unique to the cancer patient including direct complications from the cancer and indirect complications related to cancer treatment. RECENT FINDINGS: In the recent age of precision medicine, the oncologist now utilizes the genomic profile of both the patient and the tumor to provide advanced biologic therapies including targeted anticancer drugs, antiangiogenic agents, and immunotherapy...
December 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27661210/neuroleptics-in-the-management-of-delirium-in-patients-with-advanced-cancer
#8
David Hui, Rony Dev, Eduardo Bruera
PURPOSE OF REVIEW: Delirium is the most common and distressing neuropsychiatric syndrome in cancer patients. Few evidence-based treatment options are available due to the paucity of high quality of studies. In this review, we shall examine the literature on the use of neuroleptics to treat delirium in patients with advanced cancer. Specifically, we will discuss the randomized controlled trials that examined neuroleptics in the front line setting, and studies that explore second-line options for patients with persistent agitation...
December 2016: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27641565/a-e-fails-to-detect-delirium-in-advanced-cancer-patients
#9
(no author information available yet)
Delirium is the most common neuro-psychiatric syndrome in patients with advanced cancer, but it often goes undetected in the emergency department, research suggests.
August 24, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27624354/efficacy-of-ramelteon-for-delirium-after-lung-cancer-surgery
#10
Ryo Miyata, Mitsugu Omasa, Ryo Fujimoto, Hiroyuki Ishikawa, Minoru Aoki
OBJECTIVES: The aim of the study was to evaluate the feasibility of Ramelteon for the prevention of delirium after lung cancer surgery in elderly patients. METHODS: Medical records of patients over 70 years old, who underwent anatomical pulmonary resection for lung cancer at our institution from January 2013 to December 2015, were reviewed. Patients treated in 2013 and 2014 were used as a control group. Ramelteon was administered daily for 7 days after surgery. The incidence of delirium was determined based on the Intensive Care Delirium Screening Checklist (ICDSC)...
September 13, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27604806/impact-of-outpatient-palliative-care-pc-on-symptom-burden-in-patients-with-advanced-cancer-at-a-tertiary-cancer-center-in-jordan
#11
Omar Shamieh, Odai Khamash, Mustafa Khraisat, Omar Jbouri, Mohammad Awni, Abdulrahman Al-Hawamdeh, Ghadeer Arja, Sawsan Ajarmeh, Dalia Al-Rimawi, David Hui
PURPOSE: Outpatient palliative care clinics are essential for early symptom management in patients with advanced cancer. Few outpatient programs are available in the Middle East. In this prospective study, we examined the symptom changes among cancer patients seen at a palliative care clinic in Jordan. METHODS: Patients with advanced cancer who had an outpatient palliative care consultation and not delirious were enrolled. The Edmonton Symptom Assessment System (ESAS), Karnofsky Performance Scale (KPS), and Memorial Delirium Assessment Scale (MDAS) were collected at consultation and follow up visit 14-34 days later...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27585597/end-of-life-care-in-patients-with-advanced-lung-cancer
#12
REVIEW
Richard B L Lim
Despite advances in the detection, pathological diagnosis and therapeutics of lung cancer, many patients still develop advanced, incurable and progressively fatal disease. As physicians, the duties to cure sometimes, relieve often and comfort always should be a constant reminder to us of the needs that must be met when caring for a patient with lung cancer. Four key areas of end-of-life care in advanced lung cancer begin with first recognizing 'when a patient is approaching the end of life'. The clinician should be able to recognize when the focus of care needs to shift from an aggressive life-sustaining approach to an approach that helps prepare and support a patient and family members through a period of progressive, inevitable decline...
October 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27516915/west-nile-virus-encephalitis-in-a-patient-with-neuroendocrine-carcinoma
#13
Romina Deldar, Derek Thomas, Anna Maria Storniolo
Importance. Oftentimes, when patients with metastatic cancer present with acute encephalopathy, it is suspected to be secondary to their underlying malignancy. However, there are multiple causes of delirium such as central nervous system (CNS) infections, electrolyte abnormalities, and drug adverse reactions. Because West Nile Virus (WNV) neuroinvasive disease has a high mortality rate in immunosuppressed patients, a high index of suspicion is required in patients who present with fever, altered mental status, and other neurological symptoms...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27515515/the-preventative-role-of-exogenous-melatonin-administration-to-patients-with-advanced-cancer-who-are-at-risk-of-delirium-study-protocol-for-a-randomized-controlled-trial
#14
Shirley Harvey Bush, Nathalie Lacaze-Masmonteil, Marie Theresa McNamara-Kilian, Alistair Richard MacDonald, Sallyanne Tierney, Franco Momoli, Meera Agar, David Christopher Currow, Peter Gerard Lawlor
BACKGROUND: Delirium is a very common and distressing neuropsychiatric syndrome in palliative care. Increasing age, the presence of dementia and advanced cancer are well-known predisposing risk factors for delirium development. Sleep-wake cycle disturbance is frequently seen during delirium and melatonin has a pivotal role in the regulation of circadian rhythms. Current evidence across various settings suggests a potential preventative role for melatonin in patients at risk of delirium, but no studies are currently reported in patients with advanced cancer...
2016: Trials
https://www.readbyqxmd.com/read/27498911/delirium-in-patients-with-advanced-cancer
#15
Bob Carlson
No abstract text is available yet for this article.
September 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27470606/paraneoplastic-neuropsychiatric-syndrome-presenting-as-delirium
#16
Gloria Roldan Urgoiti, Aynharan Sinnarajah, Seema Hussain, Desiree Hao
Delirium in patients with cancer is associated with poor outcomes, but reversible causes need to be ruled out. We report the case of a 59-year-old woman who was presented with behavioural and cognitive changes over 2 weeks. She was non-verbal and combative, requiring involuntary admission and declaration of incompetence to make healthcare treatment decisions. Infectious and metabolic investigations and initial brain imaging were unremarkable. She was diagnosed with limited-stage small cell lung cancer and a paraneoplastic neuropsychiatric syndrome...
July 28, 2016: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/27455035/delirium-frequency-among-advanced-cancer-patients-presenting-to-an-emergency-department-a-prospective-randomized-observational-study
#17
Ahmed F Elsayem, Eduardo Bruera, Alan D Valentine, Carla L Warneke, Sai-Ching J Yeung, Valda D Page, Geri L Wood, Julio Silvestre, Holly M Holmes, Patricia A Brock, Knox H Todd
BACKGROUND: The frequency of delirium among patients with cancer presenting to the emergency department (ED) is unknown. The purpose of this study was to determine delirium frequency and recognition by ED physicians among patients with advanced cancer presenting to the ED of The University of Texas MD Anderson Cancer Center. METHODS: The study population was a random sample of English-speaking patients with advanced cancer who presented to the ED and met the study criteria...
September 15, 2016: Cancer
https://www.readbyqxmd.com/read/27454857/cancer-patients-with-delirium-in-the-emergency-department-a-frequent-and-distressing-problem-that-calls-for-better-assessment
#18
EDITORIAL
Peter G Lawlor
No abstract text is available yet for this article.
September 15, 2016: Cancer
https://www.readbyqxmd.com/read/27451253/symptom-prevalence-in-patients-with-advanced-skin-cancer
#19
Hiroyuki Goto, Shusuke Yoshikawa, Masaki Otsuka, Toshikazu Omodaka, Kosuke Yoshimi, Yuichi Yoshida, Osamu Yamamoto, Yoshio Kiyohara
Knowledge of the prevalence of symptoms in patients with incurable cancer in the terminal stage is important for clinicians. However, there has been no report on the prevalence of symptoms in patients with incurable skin cancer. We analyzed the prevalence of symptoms in 224 patients who died due to skin cancer in our center. These data were obtained from medical records compiled by a miscellaneous population of medical staff retrospectively. We evaluated the symptoms at 3 months, 1 month, 2 weeks, 1 week and 3 days before the patients died...
July 23, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27401519/the-impact-of-plasma-cholinergic-enzyme-activity-and%C3%A2-other-risk-factors-for-the-development-of%C3%A2-delirium%C3%A2-in%C3%A2-patients-receiving-palliative-care
#20
Konstanze Plaschke, Katharina A Petersen, Susanne Frankenhauser, Markus A Weigand, Jürgen Kopitz, Hubert J Bardenheuer
CONTEXT: Delirium is an important complication in palliative care patients. One of the potential risk factors for cognitive disorders is deterioration in cholinergic neurotransmission. Anticholinergic medications are known to be important owing to the association of their metabolites with significant morbidity, which is often the result of cumulative effects of medications (anticholinergic burden). Additionally, cholinergic enzymes are possible candidates reflecting the cholinergic situation in patients...
July 9, 2016: Journal of Pain and Symptom Management
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