Yuhan Han, Weiji Weng, Yongkang Zhang, Qiyuan Feng, Yuxiao Ma, Ankang Quan, Xianhua Fu, Xinxin Zhao, Loren Skudder-Hill, Jiyao Jiang, Yan Zhou, Honglin Chen, Junfeng Feng
In managing severe traumatic brain injury (TBI), emergency surgery involving the removal of damaged brain tissue and intracerebral hemorrhage is a priority. Secondary brain injury caused by oxidative stress and energy metabolic disorders, triggered by both primary mechanical brain damage and surgical insult, is also a determining factor in the prognosis of TBI. Unfortunately, the effectiveness of traditional postoperative intravenous neuroprotective agents therapy is often limited by the lack of targeting, timeliness, and side effects when neuroprotective agents systemically delivered...
January 31, 2024: Biomaterials