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https://www.readbyqxmd.com/read/29452577/polymerase-delta-interacting-protein-2-deficiency-protects-against-blood-brain-barrier-permeability-in-the-ischemic-brain
#1
Marina S Hernandes, Bernard Lassègue, Lula L Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S Kikuchi, Manuel Yepes, Kathy K Griendling
BACKGROUND: Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein that regulates vascular extracellular matrix composition and matrix metalloproteinase (MMP) activity. The blood-brain barrier (BBB) is a dynamic system assembled by endothelial cells, basal lamina, and perivascular astrocytes, raising the possibility that Poldip2 may be involved in maintaining its structure. We investigated the role of Poldip2 in the late BBB permeability induced by cerebral ischemia...
February 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29432410/angiopoietin-like-4-attenuates-brain-edema-and-neurological-deficits-in-a-mouse-model-of-experimental-intracerebral-hemorrhage
#2
Zhandong Qiu, Jia Yang, Gang Deng, Yu Fang, Dayong Li, Suming Zhang
BACKGROUND Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function following intracerebral hemorrhage (ICH). MATERIAL AND METHODS Recombinant human ANGPTL4 (rhANGPTL4; 40 µg/kg) or a vehicle was administered intraperitoneally 5 min prior to bacterial collagenase-induced ICH in male C57/B6J mice...
February 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29425910/neuroprotective-effects-of-tongxinluo-on-focal-cerebral-ischemia-and-reperfusion-injury-in-rats-associated-with-the-activation-of-the-mek1-2-erk1-2-p90rsk-signaling-pathway
#3
Zhonghai Yu, Min Cai, Xianting Li, Jingsi Zhang, Ting Wu, Feng Yang, Wen Zhu, Yijin Xiang, Wen Zhang, Jun Xiang, Dingfang Cai
Ischemic stroke brings a huge family and social burden. Although the reperfusion of ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia-reperfusion (I/R) injury further results in brain damage and even lead to death. Recent studies demonstrated that Tongxinluo (TXL) helps to protect the brain against focal cerebral I/R injury in rats by reducing neuronal apoptosis, and the MEK1/2/ERK1/2/90 ribosomal S6 kinase (p90RSK) pathway may be involved in this protective effect. Therefore, our present research was designed to identify the potential mechanisms involved...
February 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29425850/neuroprotective-effect-of-da-chuanxiong-formula-against-cognitive-and-motor-deficits-in-a-rat-controlled-cortical-impact-model-of-traumatic-brain-injury
#4
Zhi-Ke Liu, Chun-Fai Ng, Hoi-Ting Shiu, Hing-Lok Wong, Wai-Ching Chin, Jin-Fang Zhang, Ping-Kuen Lam, Wai-Sang Poon, Clara Bik-San Lau, Ping-Chung Leung, Chun-Hay Ko
ETHNOPHARMACOLOGICAL RELEVANCE: Da Chuanxiong Formula (DCXF) is one of the famous herb pairs that contains dried rhizomes of Ligusticum chuanxiong Hort. and Gastrodia elata Bl. in the mass ratio of 4:1. This classic representative traditional Chinese medicine has been widely used to treat brain diseases like headache and migraine caused by blood stasis and wind pathogen. However, the therapeutic effect of DCXF on traumatic brain injury (TBI) has not been reported yet. AIM OF STUDY: The present study was performed to investigate the neuroprotective effects of DCXF and its underlying mechanisms in the controlled cortical impact (CCI)-induced TBI rat model...
February 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29410679/effects-of-brazilian-scorpion-venoms-on-the-central-nervous-system
#5
REVIEW
Ana Leonor Abrahão Nencioni, Emidio Beraldo Neto, Lucas Alves de Freitas, Valquiria Abrão Coronado Dorce
In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus, T. silvestres, T. brazilae, T. confluens, T. costatus, T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29408288/neuroprotective-nature-of-adipokine-resistin-in-the-early-stages-of-focal-cerebral-ischemia-in-a-stroke-mouse-model
#6
Sedigheh Behrouzifar, Abedin Vakili, Ahmad Reza Bandegi, Parviz Kokhaei
New evidence suggests that resistin may have a therapeutic potential effect in management of neurodegenerative disease; but its role in the pathophysiology of stroke-induced injuries is not understood. However, further investigations are required to elucidate the effect of resistin and explore its possible molecular mechanisms on the ischemic reperfusion injury. Transient focal cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO) in mice. Animal treated with resistin at doses of 25, 50, 100, 200, and 400 ng/mouse, on the MCAO commencement...
February 2, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29386039/posterior-reversible-encephalopathy-syndrome-secondary-to-asymptomatic-poststreptococcal-glomerulonephritis-in-a-child-with-sickle-cell-anemia-a-case-report
#7
Ehab Hanafy, Duaa Alshareef, Suhaila Osman, Abdullah Al Jabri, Faisal Nazim, Gihan Mahmoud
BACKGROUND: Posterior reversible encephalopathy syndrome is a neurotoxic condition that occurs as a result of the failure of posterior circulatory autoregulation in response to acute changes in blood pressure. Overperfusion with resultant disruption of the blood-brain barrier results in vasogenic edema, but not infarction. Posterior reversible encephalopathy syndrome can be the presenting feature of postinfectious glomerulonephritis, which has been reported in approximately 5% of hospitalized children, and it has been reported in very few cases of adult patients with sickle cell anemia...
February 1, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29375693/simvastatin-improves-intracerebral-hemorrhage-through-nf-%C3%AE%C2%BAb-mediated-apoptosis-via-the-myd88-trif-signaling-pathway
#8
Chengyao Gu, Yunqin Wu, Zhenyi Fan, Weiwei Han
The aim was to investigate the neuroprotective effects and potential mechanism mediated by simvastatin in a mouse model of intracerebral hemorrhage. CD-1 mice were subjected to infusion of collagenase type IV into the left striatum in order to induce intracerebral hemorrhage. Western blot analysis, the TUNEL assay and the modified neurological severity score were used in the present study to analyze the efficacy of simvastatin for intracerebral hemorrhage. The results demonstrated that simvastatin treatment improved the cerebral water content and blood-brain barrier disruption in the intracerebral hemorrhage animals...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29353043/progression-of-vasogenic-edema-induced-by-activated-microglia-under-permanent-middle-cerebral-artery-occlusion
#9
Miki Tanaka, Yasuhiro Ishihara, Shodo Mizuno, Atsuhiko Ishida, Christoph F Vogel, Mayumi Tsuji, Takeshi Yamazaki, Kouichi Itoh
Brain edema is a severe complication that accompanies ischemic stroke. Increasing evidence shows that inflammatory cytokines impair tight junctions of the blood-brain barrier, suggesting the involvement of microglia in brain edema. In this study, we examined the role of microglia in the progression of ischemic brain edema using mice with permanent middle cerebral artery occlusion. The intensity of T2-weighted imaging (T2WI) in the cerebral cortex and the striatum was elevated 3 h after occlusion and spread to peripheral regions of the ischemic hemisphere...
January 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29350576/posterior-reversible-encephalopathy-syndrome-in-stroke-prone-spontaneously-hypertensive-rats-on-high-salt-diet
#10
Fanny Herisson, Iris Zhou, Jerome Mawet, E Du, Arnavaz H Barfejani, Tao Qin, Marilyn J Cipolla, Philip Z Sun, Natalia S Rost, Cenk Ayata
Stroke-prone spontaneously hypertensive rats (SHRSP) on high-salt diet are characterized by extremely high arterial pressures, and have been endorsed as a model for hypertensive small vessel disease and vascular cognitive impairment. However, rapidly developing malignant hypertension is a well-known cause of posterior reversible encephalopathy syndrome (PRES) in humans, associated with acute neurological deficits, seizures, vasogenic cerebral edema and microhemorrhages. In this study, we aimed to examine the overlap between human PRES and SHRSP on high-salt diet...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29316834/delayed-administration-of-bq788-an-etb-antagonist-after-experimental-traumatic-brain-injury-promotes-recovery-of-blood-brain-barrier-function-and-reduction-of-cerebral-edema-in-mice
#11
Shotaro Michinaga, Akimasa Kimura, Shunichi Hatanaka, Shizuho Minami, Arisa Asano, Yuki Ikushima, Shingo Matsui, Yoshiya Toriyama, Manami Fujii, Yutaka Koyama
Traumatic brain injury (TBI) is induced by immediate physical disruption of brain tissue, and causes death and disability. Studies on experimental TBI animal models show that disruption of the blood-brain barrier (BBB) underlies brain edema and neuroinflammation during the delayed phase of TBI. In neurological disorders, endothelin-1 (ET-1) is involved in BBB dysfunction and brain edema. In this study, the effect of ET antagonists on BBB dysfunction and brain edema were examined in a mouse focal TBI model using lateral fluid percussion injury (FPI)...
January 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29313473/1-5-tesla-magnetic-resonance-imaging-to-investigate-potential-etiologies-of-brain-swelling-in-pediatric-cerebral-malaria
#12
Michael J Potchen, Samuel D Kampondeni, Karl B Seydel, E Mark Haacke, Sylvester S Sinyangwe, Musaku Mwenechanya, Simon J Glover, Danny A Milner, Eric Zeli, Colleen A Hammond, David Utriainen, Kennedy Lishimpi, Terrie E Taylor, Gretchen L Birbeck
The hallmark of pediatric cerebral malaria (CM) is sequestration of parasitized red blood cells in the cerebral microvasculature. Malawi-based research using 0.35 Tesla (T) magnetic resonance imaging (MRI) established that severe brain swelling is associated with fatal CM, but swelling etiology remains unclear. Autopsy and clinical studies suggest several potential etiologies, but limitations of 0.35 T MRI precluded optimal investigations into swelling pathophysiology. A 1.5 T MRI in Zambia allowed for further investigations including susceptibility-weighted imaging (SWI)...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29258866/suppression-of-nlrp3-attenuates-hemorrhagic-transformation-after-delayed-rtpa-treatment-in-thromboembolic-stroke-rats-involvement-of-neutrophil-recruitment
#13
Zhiliang Guo, Shuhong Yu, Xin Chen, Ping Zheng, Ting Hu, Zhenhui Duan, Xiaoyun Liu, Qian Liu, Ruidong Ye, Wusheng Zhu, Xinfeng Liu
BACKGROUND: Inflammation and neutrophils play pivotal roles in hemorrhagic transformation (HT) after recombinant tissue plasminogen activator (rtPA) treatment in stroke; however, the contribution of Nod-like receptor protein 3 (NLRP3), a key component of the innate immune system, is not yet known. This study aimed to explore the role of NLRP3 in the delayed rtPA-induced HT and its association with the neutrophil recruitment. METHODS: Rats were subjected to thromboembolic focal cerebral ischemia and delayed rtPA treatment at 4 h after ischemia to mimic HT...
December 16, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29228667/metformin-ameliorates-sepsis-induced-brain-injury-by-inhibiting-apoptosis-oxidative-stress-and-neuroinflammation-via-the-pi3k-akt-signaling-pathway
#14
Guangming Tang, Huiyun Yang, Jing Chen, Mengrao Shi, Lingqing Ge, Xuhua Ge, Guoji Zhu
Sepsis-induced brain injuries increase mortality, morbidity, cognitive impairment and lack of effective therapeutic treatment. Previous studies have suggested that metformin provides neuroprotective effects against ischemia, brain trauma and other brain damage, but whether metformin protects a septic brain remains unknown. Thus, the aim of this study is to investigate the possible effects and the mechanism of metformin against septic brain damage using the cecal ligation and puncture (CLP) model. Mice were randomly divided into five groups: the Sham group, CLP group, CLP+ Met group, CLP+ vehicle group and CLP+ Met+ LY group...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212744/selective-nlrp3-pyrin-domain-containing-protein-3-inflammasome-inhibitor-reduces-brain-injury-after-intracerebral-hemorrhage
#15
Honglei Ren, Ying Kong, Zhijia Liu, Dongyun Zang, Xiaoxia Yang, Kristofer Wood, Minshu Li, Qiang Liu
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. As a key component of the innate immune system, the NOD-like receptor (NLR) family, NLRP3 (pyrin domain-containing protein 3) inflammasome, when activated after ICH, promotes neuroinflammation and brain edema. MCC950 is a potent, selective, small-molecule NLRP3 inhibitor that blocks NLRP3 activation at nanomolar concentrations. Here, we examined the effect of MCC950 on brain injury and inflammation in 2 models of ICH in mice...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29208604/jcar015-in-all-a-root-cause-investigation
#16
(no author information available yet)
After conducting an internal probe of the five deaths that halted JCAR015's development for acute lymphoblastic leukemia, Juno Therapeutics has concluded that multiple factors were at play. A surge in inflammatory cytokine levels from rapid, early T-cell proliferation may have provoked the blood-brain barrier disruption seen in these patients, inducing fatal cerebral edema.
December 5, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29203310/rosiglitazone-infusion-therapy-following-minimally-invasive-surgery-for-ich-evacuation-decreased-perihematomal-glutamate-content-as-well-as-bbb-permeability-in-rabbits
#17
Guofeng Wu, Yu Jiao, Junjie Wu, Riying Ren, Likun Wang, Zhouping Tang, Houguang Zhou
OBJECTIVES: To observe the effects of Rosiglitazone infusion therapy on perihematomal PPARγ, glutamate level, BBB permeability and brain edema. METHODS: A total of 50 male rabbits (2.8-3.4 kg) were randomly assigned to a normal control group (NC group), a model control group (MC group), a Rosiglitazone group (RSG group), a minimally invasive surgery group (MIS group) or a MIS combined with Rosiglitazone group (MIS+RSG group). An ICH was induced in all the animals, except for the NC group...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29201838/ganoderma-lucidum-protects-rat-brain-tissue-against-trauma-induced-oxidative-stress
#18
Özevren Hüseyin, İrtegün Sevgi, Deveci Engin, Aşır Fırat, Pektanç Gülsüm, Deveci Şenay
Objective: Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats. Methods: Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height. Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum (20 mL/kg per day via gastric gavage)...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29196215/critical-role-for-annexin-a7-in-secondary-brain-injury-mediated-by-its-phosphorylation-after-experimental-intracerebral-hemorrhage-in-rats
#19
Haiying Li, Shankai Liu, Xiaofeng Sun, Junjie Yang, Ziying Yang, Haitao Shen, Xiang Li, Yizhi Liu, Gang Chen
Glutamate excitotoxicity has been implicated in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). Synaptosome associated protein 23 (SNAP23) and SNAP25 are respectively participate in presynaptic glutamate release and postsynaptic glutamate receptor (NMDA receptor) trafficking, both of which are essential for glutamate-mediated excitatory toxicity. SNAP23 and SNAP25 exhibit high homology and SNAP23 has been shown to interact with Annexin A7 (ANXA7). This study was to examine the role of ANXA7 in ICH-induced neuronal damage...
December 2, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29195512/blood-brain-barrier-hyperpermeability-precedes-demyelination-in-the-cuprizone-model
#20
Stefan A Berghoff, Tim Düking, Lena Spieth, Jan Winchenbach, Sina K Stumpf, Nina Gerndt, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Gesine Saher
In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology. Using the toxic non-inflammatory cuprizone model of demyelination, we demonstrate, however, that the onset of persistent BBB impairment precedes demyelination. In addition to a direct effect of cuprizone on endothelial cells, a plethora of inflammatory mediators, which are mainly of astroglial origin during the initial disease phase, likely contribute to the destabilization of endothelial barrier function in vivo...
December 1, 2017: Acta Neuropathologica Communications
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