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insulin resistance depression

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https://www.readbyqxmd.com/read/29775878/repositioning-of-diabetes-treatments-for-depressive-symptoms-a-systematic-review-and-meta-analysis-of-clinical-trials
#1
REVIEW
Calum D Moulton, Christopher W P Hopkins, Khalida Ismail, Daniel Stahl
Depression is a common comorbidity in diabetes but conventional antidepressant treatments do not consistently improve outcomes. We tested whether established diabetes treatments can also improve depressive symptoms and examined biological correlates of response. We performed a multi-database systematic search of all clinical trials, which measured the effect of licensed diabetes treatments on depressive symptoms using a validated questionnaire. Results of randomised controlled trials (RCT's) were pooled for meta-analysis...
May 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29758402/lactation-related-changes-in-tissue-expression-of-pedf-in-dairy-cows
#2
H Sadri, B Saremi, S Dänicke, J Rehage, M Mielenz, A Hosseini, H Sauerwein
Pigment epithelium-derived factor (PEDF) is evolving as metabolic regulatory protein. Albeit mostly considered in only pathological conditions related to excess energy intake resulting in obesity and insulin resistance, PEDF is likely to be involved in other physiological processes such as the homeorhetic adaptation of metabolism to lactation. We aimed to characterize the expression of PEDF and its association to the concomitant mobilization of body reserves during lactation in nonobese subjects. This mobilization is particularly distinct in dairy cows, and we therefore assessed the mRNA expression of PEDF and its putative receptors in different tissues in 2 trials with dairy cows fed with or without conjugated linoleic acids (CLAs)...
April 17, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29709497/reduced-cortical-excitability-neuroplasticity-and-salivary-cortisol-in-11-13-year-old-children-born-to-women-with-gestational-diabetes-mellitus
#3
Jago M Van Dam, Amy J Garrett, Luke A Schneider, Nicolette A Hodyl, Mitchell R Goldsworthy, Suzette Coat, Janet A Rowan, William M Hague, Julia B Pitcher
BACKGROUND: Children exposed to gestational diabetes mellitus (GDM) in utero are at increased risk of neurodevelopmental difficulties, including autism and impaired motor control. However, the underlying neurophysiology is unknown. METHODS: Using transcranial magnetic stimulation, we assessed cortical excitability, long-term depression (LTD)-like neuroplasticity in 45 GDM-exposed and 12 control children aged 11-13 years. Data were analysed against salivary cortisol and maternal diabetes severity and treatment (insulin [N = 22] or metformin [N = 23]) during pregnancy...
April 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29701938/childhood-adversity-and-schizophrenia-the-protective-role-of-resilience-in-mental-and-physical-health-and-metabolic-markers
#4
Ellen E Lee, Averria Sirkin Martin, Xin Tu, Barton W Palmer, Dilip V Jeste
OBJECTIVE: To determine the impact of childhood adversity and current (adulthood) resilience on mental and physical health and markers of metabolic function among adults with schizophrenia and nonpsychiatric comparison participants (NCs). METHODS: We conducted a cross-sectional study of 114 participants with schizophrenia (DSM-IV-TR criteria) and 101 NCs aged 26-65 years during 2012-2017. Sociodemographic, clinical, and laboratory measures were examined. Childhood Trauma Questionnaire was used to retrospectively assess emotional abuse/neglect, physical abuse/neglect, and sexual abuse experienced during childhood...
April 17, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29664737/insulin-regulates-astrocyte-gliotransmission-and-modulates-behavior
#5
Weikang Cai, Chang Xue, Masaji Sakaguchi, Masahiro Konishi, Alireza Shirazian, Heather A Ferris, Mengyao Li, Ruichao Yu, Andre Kleinridders, Emmanuel N Pothos, C Ronald Kahn
Complications of diabetes affect tissues throughout body, including central nervous system. Epidemiological studies show that diabetic patients have increased risk of depression, anxiety, age-related cognitive decline and Alzheimer's disease. Mice lacking insulin receptor in brain or on hypothalamic neurons display an array of metabolic abnormalities, however, the role of insulin action on astrocytes and neurobehaviors remains less well-studied. Here, we demonstrate that astrocytes are a direct insulin target in the brain and that knockout of IR on astrocytes causes increased anxiety and depressive-like behaviors in mice...
April 17, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29656013/escitalopram-alleviates-stress-induced-alzheimer-s-disease-like-tau-pathologies-and-cognitive-deficits-by-reducing-hypothalamic-pituitary-adrenal-axis-reactivity-and-insulin-gsk-3%C3%AE-signal-pathway-activity
#6
Chao Wu, Wei-Gang Gong, Yan-Juan Wang, Jun-Jun Sun, Hong Zhou, Zhi-Jun Zhang, Qing-Guo Ren
Chronic stress, a causal factor for depression, can also cause cognitive impairments and tau pathology. However, whether and how the selective serotonin reuptake inhibitor antidepressant escitalopram ameliorates these effects are still unclear. In the present study, rats were subjected to chronic mild unpredictable stress for 8 weeks. Following the initial 4 weeks, the stressed animals were separated into susceptible (depressive) and unsusceptible (resistant) groups based on behavioral tests. Then, escitalopram (10 mg/kg i...
March 19, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29596854/brain-and-behavioral-correlates-of-insulin-resistance-in-youth-with-depression-and-obesity
#7
Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgon
Depression, together with insulin resistance, is increasingly prevalent among youth. These conditions have traditionally been compartmentalized, but recent evidence suggests that a shared brain motivational network underlies their co-occurrence. We posit that, in the context of depressive symptoms, insulin resistance is associated with aberrant structure and functional connectivity in the Anterior Cingulate Cortex (ACC) and hippocampus. This motivational neural circuit underlies dysfunctional behavioral responses and increased sensitivity to rewarding aspects of ingesting high calorie food that lead to disinhibition of eating even when satiated...
April 5, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29579625/course-of-bipolar-illness-worsens-after-onset-of-insulin-resistance
#8
Kathleen Cairns, Terrence McCarvill, Martina Ruzickova, Cynthia V Calkin
Cross-sectional studies indicate that comorbid insulin resistance (IR) and type 2 diabetes are associated with a more severe course of bipolar disorder (BD); however, this relationship has not previously been assessed longitudinally. To address this, we reviewed health records of a case series of six patients with BD and comorbid IR. Severity and length of affective episodes (both mania and depression) over the lifetime were recorded using the Affective Morbidity Index; these data were obtained from ongoing prospective follow-up and from detailed retrospective chart reviews...
March 14, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29569318/insulin-resistance-is-associated-with-smaller-brain-volumes-in-a-preliminary-study-of-depressed-and-obese-children
#9
Owen R Phillips, Alexander K Onopa, Yevgeniya V Zaiko, Manpreet K Singh
OBJECTIVE: During childhood, the brain can consume up to 65% of total calories and a steady supply of the brain's main fuel glucose needs to be maintained. Though the brain itself is not dependent on insulin for the uptake of glucose, insulin plays an important role in energy homeostasis. Thus, risk for insulin resistance during brain development may negatively impact whole brain volume. METHODS: We investigated the link between insulin resistance and whole brain volume as measured by structural MRI in 46 unmedicated depressed and overweight youth between the ages of 9 to 17 years...
March 22, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29566382/testosterone-deprivation-aggravates-left-ventricular-dysfunction-in-male-obese-insulin-resistant-rats-via-impairing-cardiac-mitochondrial-function-and-dynamics-proteins
#10
Nattayaporn Apaiajai, Titikorn Chunchai, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C Chattipakorn, Nipon Chattipakorn
BACKGROUND: We have previously reported that testosterone deprivation at a very young age accelerated, but did not aggravate, left-ventricular (LV) dysfunction in obese insulin-resistant rats. However, the effects of testosterone deprivation during adulthood on LV function in obese insulin-resistant rats remains unclear. We hypothesized that testosterone deprivation aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics proteins, a reduction in insulin receptor function, and an increase in apoptosis in obese insulin-resistant rats...
March 22, 2018: Gerontology
https://www.readbyqxmd.com/read/29553261/large-yellow-tea-attenuates-macrophage-related-chronic-inflammation-and-metabolic-syndrome-in-high-fat-diet-treated-mice
#11
Na Xu, Jun Chu, Min Wang, Ling Chen, Liang Zhang, Zhongwen Xie, Jinsong Zhang, Chi-Tang Ho, Daxiang Li, Xiaochun Wan
Large yellow tea is a traditional beverage in China with unique toasty flavor. Preliminary study using 3T3-L1 cells indicted that large yellow tea, possessed more potent lipid-lowering efficacy than green, black, dark and white teas. In the present study we further investigated its influence on metabolic syndrome in high-fat diet (HFD) mouse model with an emphasis on dose response. Thirty-two C57BL/6 male mice were randomly divided into 4 groups: low-fat diet (LFD), HFD, HFD+2.5% large yellow tea hot-water extract (YT, equivalent to 10 cups of tea daily for humans), HFD+0...
March 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29538217/correlation-between-acute-stroke-induced-white-matter-lesions-and-insulin-resistance
#12
Cheng-Jin You, Dan Liu, Li-Li Liu, Guo-Zhong Li
The present study was to examine the relationship between white matter lesions (WMLs) and insulin resistance (IR) in patients with acute stroke and evaluate clinical prognosis.Around 200 patients with initial onset of acute stroke including 146 patients (73.0%) with WMLs and 54 patients (27%) without WMLs were analyzed by neuropsychological scales. Fasting blood glucose (FBG), fasting insulin, blood lipid, homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), creatinine, and uric acid, diabetes mellitus (DM), prediabetes (PD), and normal glucose (NG) were determined according to HbA1c levels...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29524264/regulators-of-glucocorticoid-receptor-function-in-an-animal-model-of-depression-and-obesity
#13
Anna Kurek, Katarzyna Głombik, Jan Detka, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń, Bogusława Budziszewska
Obesity is a disease that often co-occurs with depression, and some evidence indicates that chronic stress in the perinatal period, in association with overactive glucocorticoids, can cause permanent changes that increase the risk of the development of both depression and obesity later in life. However, the mechanism responsible for the overly potent action of glucocorticoids in both depression and obesity is not known. The aim of the present study was to determine the expression of glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) and the factors that affect GR function (FKBP51, Bag-1 and HSP70) in a prenatal stress animal model of depression, a model of obesity and a model of both depression and obesity...
March 9, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29507694/notoginsenoside-r1-ameliorates-diabetic-encephalopathy-by-activating-the-nrf2-pathway-and-inhibiting-nlrp3-inflammasome-activation
#14
Yadong Zhai, Xiangbao Meng, Yun Luo, Yongmei Wu, Tianyuan Ye, Ping Zhou, Shilan Ding, Min Wang, Senbao Lu, Lili Zhu, Guibo Sun, Xiaobo Sun
Numerous researches supported that oxidative stress and inflammation play important roles in the development of diabetic encephalopathy (DEP). Notoginsenoside R1 (NGR1), one major component of Panax notoginseng , is believed to have anti-oxidative, anti-inflammatory and neuroprotective properties. However, its neuroprotective effects against DEP and underlying mechanisms are still unknown. In this study, db/db mice as well as high-glucose (HG)-treated HT22 hippocampal neurons were used as in vivo and in vitro models to estimate NGR1 neuroprotection...
February 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29499467/adverse-physiological-and-psychological-effects-of-screen-time-on-children-and-adolescents-literature-review-and-case-study
#15
Gadi Lissak
A growing body of literature is associating excessive and addictive use of digital media with physical, psychological, social and neurological adverse consequences. Research is focusing more on mobile devices use, and studies suggest that duration, content, after-dark-use, media type and the number of devices are key components determining screen time effects. Physical health effects: excessive screen time is associated with poor sleep and risk factors for cardiovascular diseases such as high blood pressure, obesity, low HDL cholesterol, poor stress regulation (high sympathetic arousal and cortisol dysregulation), and Insulin Resistance...
July 2018: Environmental Research
https://www.readbyqxmd.com/read/29488304/objectively-measured-physical-activity-and-cognitive-function-in-urban-dwelling-older-adults
#16
Hiroyuki Umegaki, Taeko Makino, Kazuki Uemura, Hiroyuki Shimada, Xian W Cheng, Masafumi Kuzuya
AIM: Physical activity (PA) and cognition have reportedly been associated with each other. However, it remains to be elucidated what intensities of PA are most strongly associated with cognition. In the current study, we aimed to determine the association between the intensities of objectively measured PA and cognitive function. METHODS: The present study was a cross-sectional analysis of the data obtained at registration in a randomized control trial in Toyota, Japan...
February 28, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29484146/biomarkers-for-cognitive-decline-in-patients-with-diabetes-mellitus-evidence-from-clinical-studies
#17
Xue Zhao, Qing Han, You Lv, Lin Sun, Xiaokun Gang, Guixia Wang
Diabetes mellitus is considered as an important factor for cognitive decline and dementia in recent years. However, cognitive impairment in diabetic patients is often underestimated and kept undiagnosed, leading to thousands of diabetic patients suffering from worsening memory. Available reviews in this field were limited and not comprehensive enough. Thus, the present review aimed to summarize all available clinical studies on diabetic patients with cognitive decline, and to find valuable biomarkers that might be applied as diagnostic and therapeutic targets of cognitive impairment in diabetes...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29476696/treatment-of-a-case-of-severe-insulin-resistance-as-a-result-of-a-pik3r1-mutation-with-a-sodium-glucose-cotransporter-2-inhibitor
#18
Tetsushi Hamaguchi, Yushi Hirota, Takehito Takeuchi, Yasushi Nakagawa, Atsuko Matsuoka, Masaaki Matsumoto, Hiroyuki Awano, Kazumoto Iijima, Pei Chieng Cha, Wataru Satake, Tatsushi Toda, Wataru Ogawa
A Japanese woman aged in her late 30s with severe insulin resistance and bodily features including a triangular face, prominent forehead, small chin, large and low-set ears, and ocular depression was investigated. A similar phenotype was not observed in other family members with the exception of her son, suggesting that the condition was caused by a de novo mutation that was transmitted from mother to son. Exome analysis showed the presence in the proband and her son of a c.1945C>T mutation in PIK3R1, a common mutation associated with SHORT (short stature, hyperextensibility of joints and/or inguinal hernia, ocular depression, Rieger anomaly, and teething delay) syndrome...
February 24, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29472241/adrenal-activity-and-metabolic-risk-during-randomized-escitalopram-or-placebo-treatment-in-pcos
#19
Dorte Glintborg, Magda Lambaa Altinok, Pernille Ravn, Kurt Bjerregaard Stage, Kurt Højlund, Marianne Andersen
BACKGROUND/AIMS: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, adrenal hyperactivity and decreased mental health. We aimed to investigate the changes in adrenal activity, metabolic status and mental health in PCOS during treatment with escitalopram or placebo. METHODS: Forty-two overweight premenopausal women with PCOS and no clinical depression were randomized to 12-week SSRI (20 mg escitalopram/day, n  = 21) or placebo ( n  = 21)...
March 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29451831/high-dose-perinatal-folic-acid-supplementation-alters-insulin-sensitivity-in-sprague-dawley-rats-and-diminishes-the-expression-of-adiponectin
#20
Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofolorunso
The possible intake of folate in excess of the recommended upper levels is a matter of critical importance. This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. The study included 20 female rats divided into two groups: control group and FAS group (receiving high folic acid supplemented diet). Both groups of female rats were mated and pregnancy confirmed...
February 16, 2018: Journal of Dietary Supplements
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