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insulin resistance depression

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https://www.readbyqxmd.com/read/28325221/is-metabolic-dysregulation-associated-with-antidepressant-response-in-depressed-women-in-climacteric-treated-with-individualized-homeopathic-medicines-or-fluoxetine-the-homdep-menop-study
#1
Emma Del Carmen Macías-Cortés, Lidia Llanes-González, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil
BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28319003/insulin-resistance-and-cognitive-performance-in-type-2-diabetes-the-maastricht-study
#2
Stefan L C Geijselaers, Simone J S Sep, Miranda T Schram, Martin P J van Boxtel, Ronald M A Henry, Frans R J Verhey, Abraham A Kroon, Nicolaas C Schaper, Pieter C Dagnelie, Carla J H van der Kallen, Coen D A Stehouwer, Geert Jan Biessels
AIMS: Type 2 diabetes, hyperinsulinemia, and insulin resistance are associated with cognitive impairment. Experimental studies indicate that insulin signaling in the brain is related to cognitive performance. Here we evaluated whether insulin-related variables contribute to the variance in cognitive performance among individuals with type 2 diabetes. METHODS: A total of 806 individuals with type 2 diabetes (mean age 62±8years, HbA1c 6.9±1.1%) completed a neuropsychological test battery...
February 12, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28259714/protective-effect-of-losartan-and-ramipril-against-stress-induced-insulin-resistance-and-related-complications-anti-inflammatory-mechanisms
#3
Barinder Singh, Ashish Mourya, Sangeeta Pilkhwal Sah, Anil Kumar
Chronic restraint stress (CRS) is known to cause various behavioural and biochemical alterations, leading to several negative health outcomes. The present study was designed to explore the impact of inhibiting Renin angiotensin aldosterone system (RAAS) and inflammatory pathways in stress pathophysiology. In the present study, male LACA mice were subjected to restraint stress daily for 30 days. Losartan, nimesulide, ramipril, minocycline and their combinations were administered 45min prior to restraint stress daily and their effects were observed...
March 1, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28238069/novel-5-ht3-receptor-antagonist-qcm-4-attenuates-depressive-like-phenotype-associated-with-obesity-in-high-fat-diet-fed-mice
#4
Yeshwant Kurhe, R Mahesh, Thangaraj Devadoss
RATIONALE: Depression associated with obesity remains an interesting area to study the biological mechanisms and novel therapeutic intervention. OBJECTIVES: The present study investigates the effect of a novel 5-HT3 receptor antagonist 3-methoxy-N-p-tolylquinoxalin-2-carboxamide (QCM-4) on several pathogenic markers of depression associated with obesity such as plasma insulin resistance, hippocampal cyclic adenosine monophosphate (cAMP), brain-derived neurotrophic factor (BDNF), serotonin (5-HT) concentrations, hippocampal neuronal damage, and p53 protein expression in high-fat-diet (HFD)-fed mice...
February 25, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28184199/oxidative-modification-in-the-salivary-glands-of-high-fat-diet-induced-insulin-resistant-rats
#5
Urszula Kołodziej, Mateusz Maciejczyk, Agnieszka Miąsko, Jan Matczuk, Małgorzata Knaś, Piotr Żukowski, Małgorzata Żendzian-Piotrowska, Jan Borys, Anna Zalewska
Still little is known about the role of oxidative stress (OS) in the pathogenesis of the salivary gland dysfunction in the course of insulin resistance (IR). To induce IR rats was fed with a high fat diet (HFD) during 8 weeks. Stimulated and non-stimulated salivary flow rate, total protein, as well as oxidative damage markers: 4-HNE protein adduct, 8-isoprostanes (8-isoP), 8-hydroxy-D-guanosine (8-OHdG), advanced oxidation protein product (AOPP), and protein carbonyls (PC) were determined in the plasma and submandibular and parotid glands of IR and control rats...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28179267/obesity-and-pregnancy-mechanisms-of-short-term-and-long-term-adverse-consequences-for-mother-and-child
#6
REVIEW
Patrick M Catalano, Kartik Shankar
Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased...
February 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28168992/the-relationship-between-atypical-depression-and-ins%C3%A3-lin-resistance-in-patients-with-polycystic-ovary-syndrome-and-major-depression
#7
Osman Özdemir, Zehra Kurdoglu, Saliha Yıldız, Pınar Güzel Özdemir, Ekrem Yilmaz
In this study, we aimed to examine the relationship between atypical depression and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) and major depression. A total of 176 subjects (69 patients with PCOS, 58 patients with depression, and 49 healthy controls) were included in the study. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Beck Hopelessness Scale (BHS), and the Scale for Suicide Ideation (SSI) were administered. Data concerning their height, weight, fasting a...
December 3, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28152396/insulin-resistance-atherogenicity-and-iron-metabolism-in-multiple-sclerosis-with-and-without-depression-associations-with-inflammatory-and-oxidative-stress-biomarkers-and-uric-acid
#8
Sayonara Rangel Oliveira, Ana Paula Kallaur, Josiane Lopes, Andrea Name Colado Simão, Edna Maria Vissoci Reiche, Elaine Regina Delicato de Almeida, Helena Kaminami Morimoto, Wildea Lice de Carvalho Jennings de Pereira, Daniela Frizon Alfieri, Tamires Flauzino, Caio de Meleck Proença, Anna Maria Gomes, Damacio Ramón Kaimen-Maciel, Michael Maes
Depression is accompanied by metabolic disorders in iron metabolism, lipoproteins, and insulin resistance. We measured plasma levels of ferritin, iron, lipids, insulin, and glucose and computed the homeostasis model assessment (HOMA2IR) and atherogenic index of plasma (AIP) in MS patients with and without depression and healthy controls. Explanatory variables were serum uric acid, interleukin (IL)-6, lipid hydroperoxides (CL-LOOH), albumin, and C-reactive protein (CRP). Depression was assessed using the Hospital Anxiety and Depression Scale (HADS), neurological disability using the Expanded Disability Status Scale (EDSS), and disease progression using ∆EDSS over five years earlier...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28132777/reduced-muscle-mass-in-middle-aged-depressed-patients-is-associated-with-male-gender-and-chronicity
#9
Kai G Kahl, Ferdi Utanir, Ulrich Schweiger, Tillmann H Krüger, Helge Frieling, Stefan Bleich, Marcel Gutberlet, Dagmar Hartung
OBJECTIVE: Reduced muscle mass is a characteristic finding in sarcopenia, the central element of physical frailty syndrome, and a major cause of physical function decay, morbidity and mortality in the elderly. Studies so far demonstrated reduced muscle mass in depressed patients with an average age over 60years. An open question is whether muscle mass reduction is already observed earlier. Therefore, muscle mass was assessed in middle-aged male and female depressive patients, and the findings were related to indicators of hypothalamus-pituitary adrenal axis activation, lifestyle factors, endocrine and immune measures...
January 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28069387/leptin-receptor-knockout-induced-depression-like-behaviors-and-attenuated-antidepressant-effects-of-exercise-are-associated-with-stat3-socs3-signaling
#10
Weina Liu, Jiatong Liu, Jie Xia, Xiangli Xue, Hongmei Wang, Zhengtang Qi, Liu Ji
Relatively little has been known about pathophysiological mechanisms contributing to the development of neuropsychiatric symptoms in the context of metabolic syndrome. Impaired leptin signaling activation in db/db mice has been proposed as a potential link between behavioral and metabolic disorders. Our previous studies have shown that exercise has the beneficial effects on a depression-like and insulin-resistant state in mice. The present study aimed to determine whether and how leptin receptor knockout (db/db) induces depression-like behaviors, and to identify the antidepressant effects of swimming exercise in db/db mice...
January 7, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28052180/advances-in-psoriasis
#11
Jaclyn Smith, Abigail Cline, Steven R Feldman
Psoriasis treatments range from topical treatments and phototherapy to oral systemic medications and injections. Despite good control of the disease when applying appropriate treatments (according to disease severity, insurance parameters, patient preference, and patients' ability to adhere), continued advancements will allow even better symptomatic control, reduced adverse effects, and patient satisfaction. This review aims to assess traditional and new psoriasis treatments and how to apply them in clinical practice...
January 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28048971/insulin-resistance-plays-a-potential-role-in-postoperative-cognitive-dysfunction-in-patients-following-cardiac-valve-surgery
#12
Ni Tang, Rongrong Jiang, Xiaobin Wang, Jian Wen, Li Liu, Jiali Wu, Chunxiang Zhang
Severe insulin resistance(IR) promotes the development of Alzheimer disease. IR and postoperative cognitive dysfunction (POCD) are a common complication during the cardiac perioperative period. The authors hypothesized that IR of individuals with cardiac valve surgery would have increased the risk of POCD. The purpose of the study was to analyze the association of IR and POCD after cardiac valve surgery. Total 131 patients who underwent valve replacement via cardiopulmonary bypass(CPB) were included. Cognitive function was assessed by a series of neuropsychological measurements at 1 day before and 7 days after the surgery...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/28013123/a-randomized-double-blind-placebo-controlled-crossover-trial-evaluating-the-effect-of-intranasal-insulin-on-cognition-and-mood-in-individuals-with-treatment-resistant-major-depressive-disorder
#13
Danielle S Cha, Michael W Best, Christopher R Bowie, Laura Ashley Gallaugher, Hanna O Woldeyohannes, Joanna K Soczynska, Gary Lewis, Glenda MacQueen, Barbara J Sahakian, Sidney H Kennedy, Jane P Lui, Rodrigo B Mansur, Roger S McIntyre
BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) is identified as a primary therapeutic target; no current treatment is approved for the treatment of cognitive dysfunction in MDD. We examined whether intranasal insulin offered a beneficial effect across measures of cognitive function in adults with MDD. METHODS: Thirty-five adults (18-65 years of age: 47.09±9.89) meeting criteria for a major depressive episode as per the Diagnostic and Statistical Manual (DSM)-IV-Treatment Revised were included in this randomized, double blind, placebo-controlled, crossover design study...
March 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27978584/ppar-%C3%AE-agonists-for-the-treatment-of-major-depression-a-review
#14
REVIEW
R Colle, D de Larminat, S Rotenberg, F Hozer, P Hardy, C Verstuyft, B Fève, E Corruble
Introduction: Selective agonists of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) are used for the treatment of type 2 diabetes. We reviewed their efficacy and safety for the treatment of major depression and the association of their potential antidepressant effects with changes in biomarkers of metabolism and inflammation. Methods: From 8 studies, 4 open-label trials, and 4 randomized controlled trials (RCT) (3 vs. placebo and 1 vs. metformin), 448 patients with major depression were included, of which 209 patients received PPAR-γ agonists (pioglitazone or rosiglitazone) for 6-12 weeks, either alone or in add-on therapy to conventional treatments...
March 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27960010/-lipid-metabolism-abnormalities-in-chronic-kidney-disease
#15
Stefano Bianchi, Alessandro Baronti, Renato Cominotto, Roberto Bigazzi
Regardless of the etiology of renal disease, patients with chronic kidney disease (CKD) develop profound qualitative and quantitative lipoprotein metabolism abnormalities because of the presence of alterations in apolipoproteins, lipid transfer proteins, lipolytic enzymes, and lipoprotein receptors from the earlier stages of the disease. As renal function deteriorates, triglyceride concentrations increase and high-density lipoprotein cholesterol (HDL) concentrations decline, while levels of low- density lipoprotein (LDL) cholesterol remain in the normal range or become slightly decreased...
2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27938923/associations-between-actigraphy-assessed-sleep-inflammatory-markers-and-insulin-resistance-in-the-midlife-development-in-the-united-states-midus-study
#16
Tae Ho Kim, Judith E Carroll, Suk Kyoon An, Teresa E Seeman, Kee Namkoong, Eun Lee
BACKGROUND: Disturbed sleep has been associated with increased insulin resistance and elevated inflammation. Although there is growing body of evidence that activation of inflammatory pathways plays a crucial role in the development of insulin resistance, the mediational model whereby sleep disturbances influence inflammation that drives insulin resistance has not been fully assessed in general population studies with objectively measured sleep. This study aimed to examine associations between objectively measured sleep, inflammatory markers, and insulin resistance simultaneously and in a mediational analysis, thereby offering insights into the possible causal model...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27936533/endocrinology-update-testicular-hypogonadism
#17
Joel J Heidelbaugh
Testicular hypogonadism, or androgen deficiency, is defined as a clinical condition resulting from failure of the testes to produce physiologic levels of testosterone and a normal number of spermatozoa because of disruption of the hypothalamic-pituitary-gonadal axis. Testosterone deficiency (TD) is defined as a serum level less than 300 ng/dL on a morning total testosterone test. It is estimated that more than one-third of men 45 years and older have testosterone deficiency. Associated symptoms include decreased libido, erectile dysfunction, decreased physical stamina and strength, depressed mood, fatigue, increased visceral adiposity, sleep disturbance, and/or poor concentration and memory...
December 2016: FP Essentials
https://www.readbyqxmd.com/read/27935822/adipose-tissue-in-control-of-metabolism
#18
REVIEW
Liping Luo, Meilian Liu
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity...
December 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27910808/magnesium-and-depression
#19
Anna Serefko, Aleksandra Szopa, Ewa Poleszak
Magnesium is one of the most important elements in the human body and is involved in a number of biochemical processes crucial for the proper functioning of the cardiovascular, alimentary, endocrine, and osteoarticular systems. It also plays a vital modulatory role in brain biochemistry, influencing several neurotransmission pathways associated with the development of depression. Personality changes, including apathy, depression, agitation, confusion, anxiety, and delirium are observed when there is a deficiency of this element...
March 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27904611/selective-serotonin-reuptake-inhibitors-and-cardiovascular-events-a-systematic-review
#20
REVIEW
Mohammad Hassan Nezafati, Ali Eshraghi, Mohammad Vojdanparast, Saeed Abtahi, Pouya Nezafati
BACKGROUND: Given the importance of the role of depression in predicting the outcome of cardiovascular disorders, current medications for treating depression, particularly selective serotonin reuptake inhibitors (SSRIs), are taken into consideration. This study aimed to systematically review the published findings in the use of SSRIs and the risk for cardiac events. MATERIALS AND METHODS: An independent review of the Web of Science, PubMed, Scopus, Cochrane, CINAHL, index Copernicus, and Google Scholar, up to 2014, was performed...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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