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https://www.readbyqxmd.com/read/27832863/endothelial-progenitor-cells-from-human-fetal-aorta-cure-diabetic-foot-in-a-rat-model
#1
Wan-Ni Zhao, Shi-Qing Xu, Jian-Feng Liang, Liang Peng, Hong-Lin Liu, Zai Wang, Qing Fang, Meng Wang, Wei-Qin Yin, Wen-Jian Zhang, Jin-Ning Lou
OBJECTIVE: Recent evidence has suggested that circulating endothelial progenitor cells (EPCs) can repair the arterial endothelium during vascular injury. However, a reliable source of human EPCs is needed for therapeutic applications. In this study, we isolated human fetal aorta (HFA)-derived EPCs and analyzed the capacity of EPCs to differentiate into endothelial cells. In addition, because microvascular dysfunction is considered to be the major cause of diabetic foot (DF), we investigated whether transplantation of HFA-derived EPCs could treat DF in a rat model...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27824259/preliminary-evaluation-of-a-cycling-cleat-designed-for-diabetic-foot-ulcers
#2
Ryan T Crews, Steven R Smith, Ramin Ghazizadeh, Sai Yalla, Stephanie C Wu
BACKGROUND: Offloading devices for diabetic foot ulcers (DFU) generally restrict exercise. In addition to traditional health benefits, exercise could benefit DFU by increasing blood flow and acting as thermotherapy. This study functionally evaluated a cycling cleat designed for forefoot DFU. METHODS: Fifteen individuals at risk of developing a DFU used a recumbent stationary bicycle to complete one 5-minute cycling bout with the DFU cleat on their study foot and one 5-minute bout without it...
November 8, 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27697131/clinical-management-of-acute-diabetic-charcot-foot-in-denmark
#3
Rasmus Bo Jansen, Ole Lander Svendsen, Klaus Kirketerp-Møller
INTRODUCTION: Charcot foot is a severe complication to diabetes mellitus and treatment involves several different clinical specialities. Our objective was to describe the current awareness, knowledge and treatment practices of Charcot foot among doctors who handle diabetic foot disorders. METHODS: This study is based on a questionnaire survey sent out to healthcare professionals, primarily doctors, working with diabetic foot ulcers and Charcot feet in the public sector of the Danish healthcare system...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27649399/foot-temperature-trends-in-normal-diabetic-and-neuropathic-foot-populations
#4
Azza Alalwee, Jonathan D LeSar, Mina Ghassemi, Eugene Cheng, Steven Stuto, Lawrence Osher, Scott Bastian, Vincent J Hetherington, Jill Kawalec
INTRODUCTION AND OBJECTIVES: Patients with underlying peripheral neuropathy are subject to changes in foot temperature. (1,2) Of the many forms of neuropathy that affect the lower extremity, the most notable are those types associated with diabetes. The aim of this study was to look for differences in temperatures between uncomplicated diabetic, diabetic neuropathic, and non-diabetic neuropathic feet. METHODS: The feet of 75 subjects were divided into 3 groups: 1) normal (n=50 feet), 2) diabetic (n=50 feet), and 3) neuropathic (n=49 feet)...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27648117/healing-rates-in-a-multicenter-assessment-of-a-sterile-room-temperature-acellular-dermal-matrix-versus-conventional-care-wound-management-and-an-active-comparator-in-the-treatment-of-full-thickness-diabetic-foot-ulcers
#5
https://www.readbyqxmd.com/read/27637291/a-study-of-extracellular-vesicle-concentration-in-active-diabetic-charcot-neuroarthropathy
#6
K Schara, R Štukelj, J L Krek, K Lakota, S Sodin-Šemrl, A J M Boulton, V Kralj-Iglič
It was the aim of this work to determine whether the plasma concentration of extracellular vesicles (EVs) in active Diabetic Charcot Neuroarthropathy (CN) is connected to the inflammatory markers, temperature elevation in the affected foot and concentration of soluble receptor for advanced glycation end products (RAGE). EVs were isolated from peripheral blood of 35 patients with active CN. EVs were counted after repetitive centrifugation and washing of samples, by flow cytometry. Foot temperature was measured by infrared thermometer...
September 13, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27473766/sustained-release-of-stromal-cell-derived-factor-1-from-an-antioxidant-thermoresponsive-hydrogel-enhances-dermal-wound-healing-in-diabetes
#7
Yunxiao Zhu, Ryan Hoshi, Siyu Chen, Ji Yi, Chongwen Duan, Robert D Galiano, Hao F Zhang, Guillermo A Ameer
Diabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus. Altered cell migration due to microcirculatory deficiencies as well as excessive and prolonged reactive oxygen species production are implicated in the delayed healing of DFUs. The goal of this research was to assess whether sustained release of SDF-1, a chemokine that promotes endothelial progenitor cell homing and angiogenesis, from a citrate-based antioxidant thermoresponsive polymer would significantly improve impaired dermal wound healing in diabetes...
September 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27446605/charcot-arthropathy-in-ultrasound-examination-a-case-report
#8
Mateusz Płaza, Anna Nowakowska-Płaza, Marta Walentowska-Janowicz, Marek Chojnowski, Iwona Sudoł-Szopińska
This article presents a patient with a long history of type 1 diabetes mellitus complicated with neuropathy and Charcot disease. The most common cause of neuropathic osteoarthropathy, called Charcot osteoarthropathy, is poorly controlled diabetes. The clinical picture is characterized by considerable edema, redness and increased skin temperature with relatively slight pain due to injury to nerve fibers responsible for pain sensation. The differential diagnosis should include bacterial or autoimmune arthritis, arthritis associated with gout as well as venous thrombosis and injury...
June 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/27399718/portable-system-for-monitoring-the-microclimate-in-the-footwear-foot-interface
#9
José de Jesús Sandoval-Palomares, Javier Yáñez-Mendiola, Alfonso Gómez-Espinosa, José Martin López-Vela
A new, continuously-monitoring portable device that monitors the diabetic foot has shown to help in reduction of diabetic foot complications. Persons affected by diabetic foot have shown to be particularly sensitive in the plantar surface; this sensitivity coupled with certain ambient conditions may cause dry skin. This dry skin leads to the formation of fissures that may eventually result in a foot ulceration and subsequent hospitalization. This new device monitors the micro-climate temperature and humidity areas between the insole and sole of the footwear...
July 8, 2016: Sensors
https://www.readbyqxmd.com/read/27219884/clinical-evaluation-of-human-umbilical-cord-mesenchymal-stem-cell-transplantation-after-angioplasty-for-diabetic-foot
#10
H L Qin, X H Zhu, B Zhang, L Zhou, W Y Wang
Aims: The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration. The present study evaluated the effects of HUCMSC transplantation after angioplasty for treatment of diabetic foot. Methods: Included in the study were 53 patients (72 limbs) with severe symptoms of Fontaine II-IV diabetic foot accompanied by varying degrees of lower extremity arterial disease. The patients were randomly apportioned to a control group (25 patients; 38 limbs) or an experimental group (28 patients; 34 limbs)...
May 24, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27094007/implementation-of-foot-thermometry-plus-mhealth-to-prevent-diabetic-foot-ulcers-study-protocol-for-a-randomized-controlled-trial
#11
Maria Lazo-Porras, Antonio Bernabe-Ortiz, Katherine A Sacksteder, Robert H Gilman, German Malaga, David G Armstrong, J Jaime Miranda
BACKGROUND: Diabetic foot neuropathy (DFN) is one of the most important complications of diabetes mellitus; its early diagnosis and intervention can prevent foot ulcers and the need for amputation. Thermometry, measuring the temperature of the feet, is a promising emerging modality for diabetic foot ulcer prevention. However, patient compliance with at-home monitoring is concerning. Delivering messages to remind patients to perform thermometry and foot care might be helpful to guarantee regular foot monitoring...
April 19, 2016: Trials
https://www.readbyqxmd.com/read/27065215/using-noncontact-infrared-thermography-for-long-term-monitoring-of-foot-temperatures-in-a-patient-with-diabetes-mellitus
#12
Erik Staffa, Vladan Bernard, Luboš Kubíček, Robert Vlachovský, Daniel Vlk, Vojtěch Mornstein, Robert Staffa
Foot complications in persons with diabetes mellitus (DM) are associated with substantial costs and loss of quality of life. Increasing evidence suggests changes in skin temperature, measured using an infrared thermographic system (IRT), may be a predictor of foot ulcer development in patients with DM. The purpose of this case study is to describe the long-term IRT findings and overall clinical outcomes of a patient with DM and peripheral vascular disease. Foot temperature measurements using IRT were obtained slightly more than 1 year before and immediately following endovascular treatment of a 76-year-old man, a nonsmoker with type 2 DM, hypertension, and ischemic heart disease with cardiac arrhythmia...
April 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/27064366/use-of-smartphone-attached-mobile-thermography-assessing-subclinical-inflammation-a-pilot-study
#13
COMPARATIVE STUDY
T Kanazawa, G Nakagami, T Goto, H Noguchi, M Oe, T Miyagaki, A Hayashi, S Sasaki, H Sanada
OBJECTIVE: To verify the reliability and validity of FLIR ONE, a device connected to a smartphone, for the assessment of inflammation based on relative temperature increase compared with the thermography routinely used in pressure ulcer (PU) and diabetic foot assessment. METHOD: Participants in this pilot cross-sectional observational study were recruited from the patients in the PU team rounds and the diabetic foot outpatient clinic at the university hospital in January 2015...
April 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27031550/dermacell-human-acellular-dermal-matrix-allograft-a-case-report
#14
Windy E Cole
Diabetes often causes ulcers on the feet of diabetic patients. A 56-year-old, insulin-dependent, diabetic woman presented to the wound care center with a Wagner grade 3 ulcer of the right heel. She reported a 3-week history of ulceration with moderate drainage and odor and had a history of ulceration and osteomyelitis in the contralateral limb. Rigorous wound care, including hospitalization; surgical incision and drainage; intravenous antibiotic drug therapy; vacuum-assisted therapy; and a new room temperature, sterile, human acellular dermal matrix graft were used to heal the wound, save her limb, and restore her activities of daily living...
March 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27030654/-effects-of-san-huang-sheng-fu-oil-on-peripheral-circulatory-disorders-and-foot-ulcers-in-diabetic-rats-and-the-mechanisms
#15
Y Wan, Y J Yang, Y S Li, X J Li, W Zhang, M Liu, H B Tang
OBJECTIVE: To observe the effects of San-huang-sheng-fu oil (S) on peripheral circulatory disorders and foot ulcers in diabetic rats and the relevant mechanisms. METHODS: (1) Twenty-five Wistar rats were divided into non-diabetes (N), diabetes and sham treatment (DS), metformin (M), S, and combined treatment (CT) groups according to the random number table, with 5 rats in each group. Rats in group N were injected with sodium citrate buffer solution, while rats in the other 4 groups were injected with 10 mg/mL streptozotocin to induce diabetes...
March 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27016885/dermatological-and-musculoskeletal-assessment-of-diabetic-foot-a-narrative-review
#16
REVIEW
Azam Arsanjani Shirazi, Morteza Nasiri, Leila Yazdanpanah
AIMS: Diabetic Foot Syndrome (DFS) is the most costly and devastating complication of diabetes mellitus (DM), which early effective assessment can reduce the severity of complications including ulceration and amputations. This study aimed to review dermatological and musculoskeletal assessment of diabetic foot. MATERIALS AND METHODS: In this review article, we searched for articles published between March 1, 1980 and July 28, 2015 in PubMed, Science Direct, Embase, Web of Science, and Scopus, for both English and non-English language articles with the following keywords: "Diabetic foot syndrome", "Ulceration", "Amputation", "Foot assessment", "Skin disorders" and "Musculoskeletal deformities"...
April 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/26933467/healing-rates-in-a-multicenter-assessment-of-a-sterile-room-temperature-acellular-dermal-matrix-versus-conventional-care-wound-management-and-an-active-comparator-in-the-treatment-of-full-thickness-diabetic-foot-ulcers
#17
Jodi Walters, Shawn Cazzell, Hau Pham, Dean Vayser, Alexander Reyzelman
OBJECTIVE: The purpose of this 16-week, multicenter, randomized, controlled trial was to assess the healed ulcer rate of a human acellular dermal matrix, DermACELL, compared with conventional care and a second acellular dermal matrix, Graftjacket, in the treatment of full-thickness diabetic foot ulcers. METHODS: One hundred sixty-eight patients were randomized into DermACELL, conventional care, and Graftjacket treatment arms in a 2:2:1 ratio. Patients in the acellular dermal matrix groups received either 1 or 2 applications of the graft at the discretion of the investigator...
2016: Eplasty
https://www.readbyqxmd.com/read/26889255/clinical-observation-of-the-application-of-autologous-peripheral-blood-stem-cell-transplantation-for-the-treatment-of-diabetic-foot-gangrene
#18
Shi-Min Xu, Ting Liang
The aim of the present study was to investigate the optimal mobilization plan in autologous peripheral blood stem cell transplantation for the treatment of diabetic foot and to observe its clinical curative effect. A total of 127 patients with diabetic foot were treated with different doses of granulocyte colony stimulating factor (G-CSF) to mobilize their hematopoietic stem cells. Subsequently, the extracted stem cell suspension was injected into the ischemic lower extremities along the blood vessels in the areas presenting with pathological changes...
January 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26797153/variation-of-surface-temperatures-of-different-ground-materials-on-hot-days-burn-risk-for-the-neuropathic-foot
#19
Thomas Clifton, Teng-Wei Khoo, Alice Andrawos, Sumana Thomson, John Edward Greenwood
The purpose of this study is to assess the relationship between ambient temperature and surface temperatures of commonly used building/ground materials, in order to estimate the risk of contact thermal injury. It is an observational study where the air ambient temperature and the surface temperatures of slate, metal, cement, sand, brick and bitumen, were measured, in shaded and unshaded conditions, on cloudy and cloudless days in summer in Adelaide, South Australia. All unshaded surfaces reached temperatures capable of causing significant sole of foot burns given requisite exposure time in both clear and overcast conditions, even with a relatively low ambient temperature...
March 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/26674219/ultrasound-diagnosed-bone-and-joint-destruction-as-a-typical-image-in-advanced-charcots-arthropathy-case-report
#20
Aleksandra Konarzewska, Ludomira Rzepecka-Wejs, Anna Korzon-Burakowska
The paper presents a case of Charcot foot in a patient with long standing type 2 diabetes and complicated by peripheral neuropathy. It was initially diagnosed by an ultrasound examination and subsequently confirmed by an X-ray and an magnetic resonance imaging. Diabetic neuropathy is nowadays the most frequent cause of Charcot arthropathy, although it can be also a result of other diseases of the nervous system. In the acute phase the patient usually presents with edema, redness and increased temperature of the foot, which can suggest many other diagnoses including bacterial infection, gout, venous thrombosis or trauma...
June 2012: Journal of Ultrasonography
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