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Corticosteroid for community acquired pneumonia

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https://www.readbyqxmd.com/read/27846240/efficacy-and-safety-of-adjunctive-corticosteroids-therapy-for-severe-community-acquired-pneumonia-in-adults-an-updated-systematic-review-and-meta-analysis
#1
Jirui Bi, Jin Yang, Ying Wang, Cijiang Yao, Jing Mei, Ying Liu, Jiyu Cao, Youjin Lu
BACKGROUND: Adjunctive corticosteroids therapy is an attractive option for community-acquired pneumonia (CAP) treatment. However, the effectiveness of adjunctive corticosteroids on mortality of CAP remains inconsistent, especially in severe CAP. We performed a meta-analysis to evaluate the efficacy and safety of adjunctive corticosteroids in severe CAP patients. METHODS: Three databases of PubMed, EMBASE and Cochrane Library were searched for related studies published in English up to December, 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27694410/corticosteroids-for-community-acquired-pneumonia-a-critical-view-of-the-evidence
#2
James D Chalmers
No abstract text is available yet for this article.
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27614658/benefit-of-adjunct-corticosteroids-for-community-acquired-pneumonia-in-diabetic-patients
#3
Milica Popovic, Claudine A Blum, Nicole Nigro, Beat Mueller, Philipp Schuetz, Mirjam Christ-Crain
AIMS/HYPOTHESIS: We have recently shown that adjunct prednisone shortens the time taken to reach clinical stability (time to clinical stability, TTCS) in patients with community-acquired pneumonia (CAP). Considering the hyperglycaemic effects of prednisone, there are concerns about the efficacy and safety of this therapy for diabetic patients with CAP. Our objective was to evaluate whether diabetes and/or hyperglycaemia on admission to hospital has an influence on the effect of corticosteroids on outcome in a well-defined cohort of patients with CAP...
September 10, 2016: Diabetologia
https://www.readbyqxmd.com/read/27583588/community-acquired-pneumonia-still-a-major-burden-of-disease
#4
Charles Feldman, Ronald Anderson
PURPOSE OF REVIEW: Describe recent studies that may impact on the management of community-acquired pneumonia (CAP). RECENT FINDINGS: CAP continues to be associated with a considerable burden of disease. Diagnosis remains problematic, and various biomarkers are neither accurate in the diagnosis of the presence of CAP nor superior to standard severity of illness scores in predicting outcome. Current evidence indicates that patients with nonsevere CAP can be effectively treated with antibiotic monotherapy, whereas those with severe infection, particularly ICU cases, do best with early initiation of combination antibiotic therapy...
October 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27471201/pathogen-and-antibiotic-specific-effects-of-prednisone-in-community-acquired-pneumonia
#5
Sebastian A Wirz, Claudine A Blum, Philipp Schuetz, Werner C Albrich, Christoph Noppen, Beat Mueller, Mirjam Christ-Crain, Philip E Tarr
In a double-blind, randomised, placebo-controlled trial of hospitalised patients with community-acquired pneumonia (CAP), we demonstrated shorter time to clinical stability (TTCS) with adjunct corticosteroid therapy compared with placebo.We did a pre-planned, exploratory analysis of any association between microbiological diagnosis, antibiotic treatment and procalcitonin level and effect of prednisone on TTCS, mortality, and CAP complications (n=726 participants, enrolled between December 2009 and May 2014)...
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27404370/betamethasone-and-dexamethasone-in-adult-community-acquired-bacterial-meningitis-a-quality-registry-study-from-1995-to-2014
#6
M Glimåker, M Brink, P Naucler, J Sjölin
Acute bacterial meningitis (ABM) is a highly lethal disease. Available data support the use of corticosteroids in high-income countries, but the effect on mortality is still controversial. The effects of corticosteroids on mortality and sequelae were evaluated in the national Swedish quality registry. In total, during 1995-2014 1746 adults with ABM were included, of whom 989 were treated with corticosteroids (betamethasone, n = 766; dexamethasone, n = 248; methylprednisolone, n = 2), 498 were not given corticosteroids and in 259 patients data for corticosteroids were missing...
September 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27401847/predicting-2-year-risk-of-developing-pneumonia-in-older-adults-without-dementia
#7
Michael L Jackson, Rod Walker, Sei Lee, Eric Larson, Sascha Dublin
OBJECTIVES: To develop three prognostic indices of varying degree of required detail for 2-year pneumonia risk in older adults. DESIGN: Retrospective cohort study. SETTING: Group Health (GH), an integrated healthcare delivery system. PARTICIPANTS: Community-dwelling dementia-free individuals aged 65 and older who had been GH members for at least 2 years before start of follow-up and were enrolled in the Adult Changes in Thought study (N = 3,375; development cohort, n = 2,250; validation cohort, n = 1,125...
July 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27281842/corticosteroids-for-community-acquired-pneumonia
#8
Jonathan Fu, Gary Green
No abstract text is available yet for this article.
June 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27162684/adjuvant-corticosteroids-for-patients-hospitalized-with-community-acquired-pneumonia-is-it-time
#9
Matthieu Revest, Gérald Egmann, Anthony Chapron, Stéphane Jouneau, Pierre Tattevin
No abstract text is available yet for this article.
May 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27136220/corticosteroid-therapy-for-patients-hospitalized-with-community-acquired-pneumonia
#10
Reed A C Siemieniuk, Pablo Alonso-Coello, Gordon H Guyatt
No abstract text is available yet for this article.
May 3, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27136219/corticosteroid-therapy-for-patients-hospitalized-with-community-acquired-pneumonia
#11
Meenu Singh, Nishant Jaiswal
No abstract text is available yet for this article.
May 3, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27117073/-the-indications-for-glucocorticoids-in-treating-community-acquired-pneumonia-in-adults-a-meta-analysis
#12
X L Tian, M Jiang, X F Sun, Y Z Zhan, S B Wang, S S Kang
OBJECTIVE: Community acquired pneumonia (CAP) is a common pulmonary infectious disease. Glucocorticoids (GCS) as one of the most powerful anti-inflammation drugs, are still the most controversial adjuvant therapy in treating CAP. Which sub-groups of CAP patients would benefit from GCS is a debating topic. Our aim of this study is to find the indications for GCS in treating adult CAP patients by using meta-analysis. METHOD: "Steroids, glucocorticoids, corticosteroids, hydrocortisone, prednisone, cortisol, methylprednisolone, dexamethasone"and"community-acquired pneumonia"were used as key words both in Chinese and English to search all published literature in Pubmed, EMBASE MEDLINE, Cochrane, CNKI and Wanfang Database until March 2015...
April 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27076965/corticosteroids-in-the-adjunctive-therapy-of-community-acquired-pneumonia-an-appraisal-of-recent-meta-analyses-of-clinical-trials
#13
REVIEW
Charles Feldman, Ronald Anderson
Improving the outcome of patients with community-acquired pneumonia (CAP) is an ongoing challenge, even in the setting of significant advances in antimicrobial chemotherapy and critical care. Recognition of the underlying involvement of inflammation-mediated organ dysfunction as a determinant of adverse outcomes in CAP has aroused intense interest in the protective potential of adjunctive anti-inflammatory therapies in CAP, particularly the role of corticosteroids (CS). This is the primary topic of the current review which is focused on an evaluation of the latest meta-analyses encompassing both recent and earlier clinical trials, with particular emphasis on the stringent meta-analysis undertaken by Siemieniuk and colleagues (Ann Intern Med 2015;163:519-528)...
March 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26874956/relevant-cytokines-in-the-management-of-community-acquired-pneumonia
#14
Adrian Rendon, Erick J Rendon-Ramirez, Adrian G Rosas-Taraco
Community-acquired pneumonia (CAP) is the leading cause of infectious death in the world. Immune dysregulation during acute lung infection plays a role in lung injury and the systemic inflammatory response. Cytokines seem to be major players in severe lung infection cases. Here, we present a review of published papers in the last 3 years regarding this topic. The cytokine response during pneumonia is different in bacterial vs viral infections; some of these cytokines correlate with clinical severity scales such as CURB65 or SOFA...
March 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/26859379/improving-outcomes-in-community-acquired-pneumonia
#15
REVIEW
Michael T Bender, Michael S Niederman
PURPOSE OF REVIEW: Community-acquired pneumonia (CAP) is a pervasive disease that is encountered in outpatient and inpatient settings. CAP is the leading cause of death from an infectious disease and accounts for significant worldwide morbidity and mortality. This update reviews current advances that can be used to promote improved outcomes in CAP. RECENT FINDINGS: Early recognition of CAP and its severe presentations, with appropriate site of care decisions, leads to reduced patient mortality...
May 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/26820274/what-is-the-evidence-for-harm-of-neuromuscular-blockade-and-corticosteroid-use-in-the-intensive-care-unit
#16
Djillali Annane
Neuromuscular blocking agents and corticosteroids are widely used in medicine and in particular in the intensive care unit (ICU). Neuromuscular blockade is commonly used to ease tracheal intubation, to optimize mechanical ventilation and oxygenation in acute respiratory disorders such as status asthmaticus and acute respiratory distress syndrome (ARDS), to prevent shivering during therapeutic hypothermia, and also in patients with elevated intracranial pressure. In the ICU, patients with sepsis, ARDS, community-acquired pneumonia, exacerbation of chronic obstructive pulmonary disease, severe asthma, or trauma may receive corticosteroids...
February 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26716025/caution-overestimation-of-treatment-effects-of-corticosteroid-therapy-for-community-acquired-pneumonia-in-a-meta-analysis-of-randomized-controlled-trials
#17
Wan-Jie Gu
It is well known that a meta-analysis of randomized controlled trials aims to increase the power and precision of the estimated intervention effects. However, when a meta-analysis includes a limited number of patients and a small number of events, overestimation of intervention effect estimates may occur and could cause spurious results. Although many biases can cause the overestimation, random error may be the most common cause. Trial sequential analysis (TSA) can explore the independent effect of random error on intervention effect estimates in meta-analyses and protect meta-analyses against overestimation due to random error...
November 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26701196/adjunctive-corticosteroids-improve-the-need-for-mechanical-ventilation-and-shorten-hospital-duration-in-patients-hospitalised-with-community-acquired-pneumonia
#18
COMMENT
Mirjam Christ-Crain, Willem Jan W Bos
No abstract text is available yet for this article.
April 2016: Evidence-based Medicine
https://www.readbyqxmd.com/read/26648706/the-effect-trial-evaluating-exacerbations-biomarkers-and-safety-outcomes-with-two-dose-levels-of-fluticasone-propionate-formoterol-in-copd
#19
Alberto Papi, Paul W Jones, Prashant S Dalvi, Kirsten McAulay, Tammy McIver, Sanjeeva Dissanayake
Inhaled corticosteroid/long-acting β2-agonist combination therapy is recommended in chronic obstructive pulmonary disease (COPD) patients at high risk of exacerbations. The EFFECT (Efficacy of Fluticasone propionate/FormotErol in COPD Treatment) trial is a Phase III, 52-week, randomized, double-blind study to evaluate the efficacy and safety of two doses of fluticasone propionate/formoterol compared to formoterol monotherapy in COPD patients with FEV1 ≥50% predicted and a history of exacerbations. The primary endpoint is the annualized rate of moderate and severe exacerbations...
2015: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/26540020/early-diagnosis-based-on-clinical-history-and-balf-for-successful-management-of-smoking-induced-acute-eosinophilic-pneumonia-without-unnecessary-antibiotic-usage-a-case-report
#20
Jee In Song, Yang-Ki Kim, Jung Hwa Hwang, Hyeon-Jong Yang
INTRODUCTION: Acute eosinophilic pneumonia (AEP) is a rapid onset and severe respiratory illness characterized by acute febrile respiratory insufficiency, eosinophilic infiltration in the lungs and unique findings on chest imaging. Difficulty in differentiating from other respiratory distress caused by community-acquired pneumonia may result in a delayed diagnosis or treatment with empirical antibiotics. CASE STUDY: Sixteen-year-old boy who developed AEP with marked eosinophilia in bronchoalveolar lavage fluid (BALF, 36...
2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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