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https://www.readbyqxmd.com/read/29146757/is-there-consensus-in-defining-childhood-cerebral-visual-impairment-a-systematic-review-of-terminology-and-definitions
#1
REVIEW
Hanna E A Sakki, Naomi J Dale, Jenefer Sargent, Teresa Perez-Roche, Richard Bowman
The childhood condition of visual difficulties caused by brain damage, commonly termed cortical or cerebral visual impairment (CVI), is well established but has no internationally accepted definition. Clarification of its core features is required to advance research and clinical practice. This systematic review aimed to identify the definitions of childhood CVI in the original scientific literature to describe and critically appraise a consensual definition of the condition. MEDLINE, EMBASE, PsychINFO, CINAHL and AMED databases were searched in January 2017...
November 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29144175/pregnancy-associated-plasma-protein-a-as-a-prognostic-biomarker-of-all-cause-mortality-and-cardiovascular-events-in-patients-presenting-with-chest-pain-a-systematic-review
#2
Christos A Papanastasiou, Damianos G Kokkinidis, Evangelos K Oikonomou, Vasileios G Mantziaris, T Raymond Foley, Theodoros D Karamitsos, Stephen W Waldo, Ehrin J Armstrong
AIM: Novel biomarkers have been proposed for identification of patients at greater risk of future adverse events among those presenting with chest pain. In this review, we aim to elucidate the ability of pregnancy associated plasma protein-A (PAPP-A) to predict mortality and other cardiovascular events in this patient population. METHODS: A literature search of the electronic databases Medline, Scopus, Cochrane Library and ClinicalTrials.gov was performed in order to identify studies investigating the utility of PAPP-A to predict mortality and adverse cardiovascular events in patients with chest pain...
November 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29143228/effect-of-exosome-biomarkers-for-diagnosis-and-prognosis-of-breast-cancer-patients
#3
REVIEW
M Wang, S Ji, G Shao, J Zhang, K Zhao, Z Wang, A Wu
PURPOSE: Exosomes are gradually detected as an indicator for diagnosis and prognosis of breast cancer in clinic and a systematic review was conducted. METHODS: A search for clinical studies published before July 1, 2017 was performed. Methods of exosome purification and identification from all studies were extracted. For diagnosis evaluation, the comparison of exosome biomarkers expression between breast cancer patients and healthy women was obtained; for prognosis prediction, the correlation between exosome biomarkers expression and chemotherapy resistance, overall survival (OS), disease-free survival (DFS), recurrence and metastasis of breast cancer was also extracted...
November 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29137893/advances-in-the-evaluation-of-bone-health-in-kidney-transplant-patients
#4
María José Pérez-Sáez, Daniel Prieto-Alhambra, Adolfo Díez-Pérez, Julio Pascual
Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy has yet to be established. Apart from bone biopsy, which is invasive and scarcely used, no other technique is available to accurately establish the risk of fracture in kidney patients. Techniques applied to the general population, such as bone densitometry, have not been subjected to sufficient external validation and their use is not systematic...
November 11, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29137053/prognostic-value-of-high-resolution-magnetic-resonance-imaging-in-evaluating-carotid-atherosclerotic-plaque-in-patients-with-ischemic-stroke
#5
Jin-Er Shu, Ming-Liang Ying, Xiao-Rong Chen, Jian-Jun Hua, Jie-Ting Fu, Xiu-Mei Xia, Yong-Hao Pan, Yang Jiang
BACKGROUND: Ischemic stroke (IS) is a devastating occurrence affecting millions worldwide. This study aimed to evaluate the prognostic value of high-resolution magnetic resonance imaging (HRMRI) in assessing carotid atherosclerotic plaque in IS patients. METHODS: Between January 2013 and March 2015, 338 IS patients were recruited for the investigative purposes of the study. All participants of the study underwent an HRMRI inspection procedure after being admitted into the hospital...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136602/saffron-in-the-treatment-of-depression-anxiety-and-other-mental-disorders-current-evidence-and-potential-mechanisms-of-action
#6
REVIEW
Mojtaba Shafiee, Soheil Arekhi, Alireza Omranzadeh, Amirhossein Sahebkar
BACKGROUND: Depression and anxiety are two common mental health problems with high economic and social costs. Currently, a number of treatments are available for patients with depression and anxiety disorders such as psychotherapy, electroconvulsive therapy and antidepressant drugs. Due to safety concerns, adverse effects, limited efficacy and low tolerability associated with many antidepressant and anti-anxiety medications, identification of novel agents with less toxicity and more favorable outcome is warranted...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29135084/identification-of-bioactive-scaffolds-based-on-qsar-models
#7
Tomoki Nakagawa, Tomoyuki Miyao, Kimito Funatsu
In medicinal chemistry, the molecular scaffolds commonly found in compounds with preferable biological activities are called bioactive scaffolds. They are important because if present in a structure, it is more likely that the compound will be bioactive. Traditionally, medicinal chemists use their knowledge to identify bioactive scaffolds from a given data set after systematic extraction of all candidate scaffolds. However, manually sorting all the scaffolds is not practical as the number of compounds in a data set is often very large...
November 14, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/29133324/effects-of-falls-prevention-interventions-on-falls-outcomes-for-hospitalised-adults-protocol-for-a-systematic-review-with-meta-analysis
#8
Susan C Slade, David L Carey, Anne-Marie Hill, Meg E Morris
INTRODUCTION: Falls are a major global public health problem and leading cause of accidental or unintentional injury and hospitalisation. Falls in hospital are associated with longer length of stay, readmissions and poor outcomes. Falls prevention is informed by knowledge of reversible falls risk factors and accurate risk identification. The extent to which hospital falls are prevented by evidence-based practice, patient self-management initiatives, environmental modifications and optimisation of falls prevention systems awaits confirmation...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133016/dynamic-transcriptional-control-of-macrophage-mirna-signature-via-inflammation-responsive-enhancers-revealed-using-a-combination-of-next-generation-sequencing-based-approaches
#9
Zsolt Czimmerer, Attila Horvath, Bence Daniel, Gergely Nagy, Ixchelt Cuaranta-Monroy, Mate Kiss, Zsuzsanna Kolostyak, Szilard Poliska, Laszlo Steiner, Nikolas Giannakis, Tamas Varga, Laszlo Nagy
MicroRNAs are important components of the post-transcriptional fine-tuning of macrophage gene expression in physiological and pathological conditions. However, the mechanistic underpinnings and the cis-acting genomic factors of how macrophage polarizing signals induce miRNA expression changes are not well characterized. Therefore, we systematically evaluated the transcriptional basis underlying the inflammation-mediated regulation of macrophage microRNome using the combination of different next generation sequencing datasets...
November 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29132613/identification-and-management-of-shigella-infection-in-children-with-diarrhoea-a-systematic-review-and-meta-analysis
#10
Kirkby D Tickell, Rebecca L Brander, Hannah E Atlas, Jeffrey M Pernica, Judd L Walson, Patricia B Pavlinac
BACKGROUND: Shigella infections are a leading cause of diarrhoeal death among children in low-income and middle-income countries. WHO guidelines reserve antibiotics for treating children with dysentery. Reliance on dysentery for identification and management of Shigella infection might miss an opportunity to reduce Shigella-associated morbidity and mortality. We aimed to systematically review and evaluate Shigella-associated and dysentery-associated mortality, the diagnostic value of dysentery for the identification of Shigella infection, and the efficacy of antibiotics for children with Shigella or dysentery, or both...
December 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29132441/early-screening-for-chlamydia-trachomatis-in-young-women-for-primary-prevention-of-pelvic-inflammatory-disease-i-predict-study-protocol-for-a-randomised-controlled-trial
#11
Jeanne Tamarelle, Anne C M Thiébaut, Bénédicte Sabin, Cécile Bébéar, Philippe Judlin, Arnaud Fauconnier, Delphine Rahib, Layidé Méaude-Roufai, Jacques Ravel, Servaas A Morré, Bertille de Barbeyrac, Elisabeth Delarocque-Astagneau
BACKGROUND: Genital infection with Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection, especially among young women. Mostly asymptomatic, it can lead, if untreated, to pelvic inflammatory disease (PID), tubal factor infertility and ectopic pregnancy. Recent data suggest that Ct infections are not controlled in France and in Europe. The effectiveness of a systematic strategy for Ct screening in under-25 women remains controversial. The main objective of the i-Predict trial (Prevention of Diseases Induced by Chlamydia trachomatis) is to determine whether early screening and treatment of 18- to-24-year-old women for genital Ct infection reduces the incidence of PID over 24 months...
November 13, 2017: Trials
https://www.readbyqxmd.com/read/29132315/comprehensive-genomic-analysis-of-the-cngc-gene-family-in-brassica-oleracea-novel-insights-into-synteny-structures-and-transcript-profiles
#12
Kaleem U Kakar, Zarqa Nawaz, Khadija Kakar, Essa Ali, Abdulwareth A Almoneafy, Raqeeb Ullah, Xue-Liang Ren, Qing-Yao Shu
BACKGROUND: The cyclic nucleotide-gated ion channel (CNGC) family affects the uptake of cations, growth, pathogen defence, and thermotolerance in plants. However, the systematic identification, origin and function of this gene family has not been performed in Brassica oleracea, an important vegetable crop and genomic model organism. RESULTS: In present study, we identified 26 CNGC genes in B. oleracea genome, which are non-randomly localized on eight chromosomes, and classified into four major (I-IV) and two sub-groups (i...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29131518/metabolic-profile-of-kudiezi-injection-in-rats-by-uhplc-coupled-with-fourier-transform-ion-cyclotron-resonance-mass-spectrometry
#13
Jingdan Zhang, Xiaoxue Zhang, Yangyang Zhao, Aihua Song, Wei Sun, Ran Yin
In this study, a reliable and sensitive ultra high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry method was developed for the systematic study of the metabolic profile of Kudiezi injection in rat plasma, bile, urine and feces after intravenous administration of a single dose. The chromatographic separation was performed on an Agilent Eclipse Plus C18 column (4.6 mm × 50 mm, 1.8 μm) and the identification of prototype components and metabolites was achieved on a Bruker Solarix 7...
November 13, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29130213/systematic-detection-of-poly-a-rna-interacting-proteins-and-their-differential-binding
#14
Miha Milek, Markus Landthaler
RNA-binding proteins are dynamic posttranscriptional regulators of gene expression. Identification of mRNA-binding proteins in a given experimental setting is thus of great importance. We describe a procedure to enrich for direct poly(A)(+) RNA protein binders by 4-thiouridine-enhanced UV cross-linking and oligo(dT) purification. Subsequent nuclease-mediated release of RNA-binding proteins (RBPs) from mRNA allows for detection of eluted proteins by mass spectrometry. In addition, we provide a comparative approach to detect differences in RBP binding activity upon a biological stimulus...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29129014/causal-factors-of-corruption-in-construction-project-management-an-overview
#15
REVIEW
Emmanuel Kingsford Owusu, Albert P C Chan, Ming Shan
The development of efficient and strategic anti-corruption measures can be better achieved if a deeper understanding and identification of the causes of corruption are established. Over the past years, many studies have been devoted to the research of corruption in construction management (CM). This has resulted in a significant increase in the body of knowledge on the subject matter, including the causative factors triggering these corrupt practices. However, an apropos systematic assessment of both past and current studies on the subject matter which is needful for the future endeavor is lacking...
November 11, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29128086/delayed-presentation-and-diagnosis-of-breast-cancer-in-african-women-a-systematic-review
#16
REVIEW
Carolina Espina, Fiona McKenzie, Isabel Dos-Santos-Silva
PURPOSE: Africa has low breast cancer incidence rates but high mortality rates from this disease due to poor survival. Delays in presentation and diagnosis are major determinants of breast cancer survival, but these have not been comprehensively investigated in Africa. METHODS: MEDLINE, Embase, and Global Health were searched to identify studies reporting on delays in presentation and/or diagnosis of breast cancer published between January 1, 2000 and May 31, 2016...
October 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29126412/obstetric-fistulae-in-southern-mozambique-incidence-obstetric-characteristics-and-treatment
#17
Sibone Mocumbi, Claudia Hanson, Ulf Högberg, Helena Boene, Peter von Dadelszen, Anna Bergström, Khátia Munguambe, Esperança Sevene
BACKGROUND: Obstetric fistula is one of the most devastating consequences of unmet needs in obstetric services. Systematic reviews suggest that the pooled incidence of fistulae in community-based studies is 0.09 per 1000 recently pregnant women; however, as facility delivery is increasing, for the most part, in Africa, incidence of fistula should decrease. Few population-based studies on fistulae have been undertaken in Sub-Saharan Africa, including Mozambique. This study aimed to estimate the incidence of obstetric fistulae in recently delivered mothers, and to describe the clinical characteristics and care, as well as the outcome, after surgical repair...
November 10, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29125776/unique-trapped-dimer-state-of-the-photogenerated-hole-in-the-hybrid-orthorhombic-ch3nh3pbi3-perovskite-identification-origin-and-implications
#18
Chao Peng, Jinglin Wang, Haifeng Wang, Peijun Hu
Revealing the innate character and transport of the photogenerated hole is essential to boost the high photovoltaic performance in the lead-based organohalide perovskite. However, knowledge at the atomic level is currently very limited. In this work, we systematically investigate the properties of the photogenerated hole in the orthorhombic CH3NH3PbI3 using hybrid functional PBE0 calculations with spin-orbit coupling included. An unexpected trapping state of the hole, localized as I2- (I dimer), is uncovered, which was never reported in photovoltaic materials...
November 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/29125503/patient-preferences-for-treatments-of%C3%A2-neuromuscular-diseases-a-systematic-literature-review
#19
Erik Landfeldt, Josefin Edström, Peter Lindgren, Hanns Lochmüller
BACKGROUND: Treatment decisions of neuromuscular diseases involve weighing clinical benefits and risks, as well as impact on patient social life, work status, other activities of daily living, and health-related quality of life. OBJECTIVE: To conduct a systemic literature review of patient preferences for treatments of neuromuscular diseases. METHODS: We searched Embase, Web of Science, and PubMed for full-text articles reporting results from studies of patient preferences for treatments of neuromuscular diseases...
November 8, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29124764/flank-spot-number-and-its-significance-for-systematics-taxonomy-and-conservation-of-the-near-threatened-mediterranean-trout-salmo-cettii-evidence-from-a-genetically-pure-population
#20
A Duchi
The number of spots on the flank of the Mediterranean trout Salmo cettii population from Tellesimo Stream in Sicily, Italy, varied between seven and 37, with a median and mode of 21, numbers much lower than those reported in the literature and different from those of other Italian trout populations. This finding could be ascribed to the phenotypic plasticity of the species or, alternatively, could provide evidence to support the different origin of Sicilian autochthonous trout. Given the ease of use of this character for the identification of native fish, it could be particularly important for conservation and management purposes...
November 9, 2017: Journal of Fish Biology
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