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Yan Zhang, Bin Zhang, Jiazhen Li, Xinchang Lu, Yi Zhang
Objective: To summarize the preliminary effectiveness of surgical treatment of Erdheim-Chester disease (ECD), so as to improve the understanding of the disease by orthopedic surgeons. Methods: The clinical data of 9 patients with ECD between December 2012 and October 2017 were retrospectively analysed. There were 6 males and 3 females with an median age of 42 years (range, 8-61 years). The disease duration was 4-59 months (mean, 39 months). There were 2 cases of multiple lesions, including 1 case involving soft tissue of the buttocks and bilateral tibia, 1 case involving the sinus, skull base, and proximal right tibia; 7 cases with single lesion, including 3 cases of right femoral neck, 1 case of proximal right tibia, 1 case of right humerus, and 2 cases of ribs...
August 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Doris Day, Cheryl M Burgess, Leon H Kircik
INTRODUCTION: This was a prospective non-randomized observational study of female subjects seeking treatment for cellulite who were consecutively enrolled into a registry. The objective was to evaluate the efficacy and safety of a tissue stabilized-guided subcision device for the treatment of cellulite using three-dimensional (3D) imaging analysis. METHODS: Subjects received a single treatment to the buttocks and/or posterolateral thighs with the study device. Follow-up telephone evaluations were conducted at 3 and 14 days to evaluate safety and 30 and 90 days to evaluate efficacy...
September 1, 2018: Journal of Drugs in Dermatology: JDD
Linjie Wang, Zhe Chao, Yan Wang
The AMP deaminase 1 (AMPD1) gene plays an important role in purine nucleotide interconversion and energy metabolism. In this study, two novel single nucleotide polymorphyisms (SNPs) (g.-626 G > A and g.-566 A>G) were detected in the proximal promoter region of the AMPD1 gene. The Chinese indigenous pig breeds (Meishan and Tongcheng) had higher frequencies of the G and A alleles than Western meat-type breeds (Landrace and Large White) at the g.-626 G > A and g.-566 A>G loci. The transcriptional activity of the AMPD1 promoter carrying the haplotype H1 (A-626 G-566 ) was significantly (p < 0...
September 20, 2018: DNA and Cell Biology
Duo-Xi Deng, Jie Tan, Hong Zhang, Gui-Lan Huang, Shuai Li, Kui-Kui Guo, Yun-Yun Wu, Bi-Ying Yang, Yao Xiao, Liang Peng, Hui Xie
OBJECTIVE: To observe the effect of electroacupuncture (EA) stimulation of "Shangjuxu" (ST 37, Lower Confluent point) and "Tianshu" (ST 25, Front-Mu point) on visceral pain and expression of colonic tryptase(Try), proteinase-activated receptor 2(PAR-2),transient receptor potential channel vanilloid subfamily member 1 (TPRV 1),substance P (SP) and calcitonin gene-related peptide (CGRP) in rats with irritable bowel syndrome (IBS), so as to explore its mechanisms underlying improvement of IBS...
August 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Dong Chan Lee, Dong Hwa Heo, Kyoung Seok Cho
BACKGROUND AND STUDY AIMS:  Vascular narrowing or obstruction reduces blood flow to the lower limbs during exercise or at rest. Symptoms may range from intermittent claudication to pain at rest. Narrowing of these arteries may produce pain in the buttocks, thighs, or legs. These symptoms may resemble those of lumbar radicular pain. Spine surgeons may overlook obstructive vascular lesions of the lower limbs in patients with lumbar degenerative diseases such as spinal stenosis and spondylolisthesis...
September 17, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Emily Darr, Daniel Cher
Background: Increasing long-term evidence supports the safety and effectiveness of minimally invasive sacroiliac joint fusion (SIJF) for sacroiliac joint (SIJ) dysfunction, an important cause of chronic low-back/buttock pain. Objective: To report 4-year follow-up in patients undergoing SIJF using triangular titanium implants (TTI) as part of two prospective trials. Methods: We enrolled 103 subjects at 12 centers treated with TTI in two prospective clinical trials (NCT01640353 and NCT01681004) and followed them in the current study (NCT02270203), with clinic visits at 3, 4, and 5 years...
2018: Medical Devices: Evidence and Research
Virginia Diaz, Edgardo Abalos, Guillermo Carroli
BACKGROUND: Almost 358,000 women die each year in childbirth, mainly in low-income countries. More than half of all maternal deaths occur within 24 hours of giving birth; severe bleeding in the postpartum period is the single most important cause. Depending on the rate of blood loss and other factors, such as pre-existing anaemia, untreated postpartum haemorrhage (PPH) can lead to hypovolaemic shock, multi-organ dysfunction, and maternal death, within two to six hours.This review investigated different methods for estimating blood loss...
September 13, 2018: Cochrane Database of Systematic Reviews
Scott Huff, Marshall Gillette, Jacob Stirton, Nicholas Peters, Nabil Ebraheim
Abscess of the iliopsoas muscle is a rare condition that requires a high degree of clinical suspicion for diagnosis. High mortality rates highlight the need for prompt recognition. We report the case of a 26-year-old man, with a history of intravenous drug use, who was referred from an outside facility with sacral fracture and gluteal abscess. Sacral trauma occurred 3 weeks before presentation, with progressive worsening of buttock pain. The patient was treated with irrigation and débridement of the gluteal abscess...
December 2017: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
J Doridam, A Macron, C Vergari, A Verney, P-Y Rohan, H Pillet
Pressure Ulcer (PU) prevention remains a main public health issue. The physio-pathology of this injury is not fully understood, and a satisfactory therapy is currently not available. Recently, several works suggested that mechanical strains are responsible of deformation-induced damage involved in the initiation of Deep Tissue Injury (DTI). A better assessment of the internal behavior could allow to enhance the modeling of the transmission of loads into the different structures composing the buttock. A few studies focused on the experimental in vivo buttock deformation quantification using Magnetic Resonance Imaging (MRI), but its use has important drawbacks...
August 11, 2018: Journal of Tissue Viability
Katie Propst, David M O'Sullivan, Adam C Steinberg
INTRODUCTION AND HYPOTHESIS: Pain control is a key component of postoperative care; our objective was to evaluate if use of long-acting local anesthesia at the sacrospinous ligament leads to decreased postoperative pain versus short-acting local anesthesia in patients undergoing sacrospinous ligament fixation. METHODS: Women ≥ 18 years old undergoing sacrospinous ligament fixation to treat pelvic organ prolapse were eligible to participate in this randomized trial...
September 6, 2018: International Urogynecology Journal
Fabian Echterdiek, Daniel Kitterer, Vedat Schwenger, Jörg Latus
Bondage and discipline, dominance and submission, sadism and masochism (BDSM) refers to a variety of primarily erotic practices. Although safety is crucial for most BDSM practitioners, there are violent forms that may cause serious injury. We present the case of 61-year-old man with no history of chronic kidney disease who developed severe acute anuric kidney injury following violent BDSM play. He had been strapped tightly onto a wooden spanking bench and then received approximately 1000 vigorous hits onto his bare buttocks and thighs...
August 31, 2018: BMJ Case Reports
Gkionoul Nteli Chatzioglou, Figen Govsa, Ahmet Bicer, Mehmet Asim Ozer, Yelda Pinar
BACKGROUND: As buttocks region is one of the most characteristic features of the ideal female body figure, the popularity of gluteal region contouring is on the rise. Perception of body form is influenced by its shape and size. Interventions to modify the form of this region are often difficult due to influence. The aim of this study is to investigate the attractiveness of various buttock shapes with the aid of a dedicated software. METHODS: Standard personal photographs of the lower body were obtained from 200 healthy volunteers...
August 23, 2018: Surgical and Radiologic Anatomy: SRA
Jia-Jun Feng, Jia Le See, Abby Choke, Adrian Ooi, Si Jack Chong
BACKGROUND: The pubic region is often involved in accidental hot water or soup-spill burns. Most of these wounds are superficial partial thickness burns. Due to their proximity to the urinary system, as well as vaginal and anal openings, these burns are easily contaminated. Daily dressings are routinely prescribed as the sole treatment. The cumbersome dressing process is uncomfortable and embarrassing for patients. Biobrane™ is a bilayered biosynthetic dressing. Its coverage of superficial partial thickness burns promotes wound healing and allows one-time application...
August 26, 2018: Military Medical Research
Joyce Y Cheng, Phillip R Cohen
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a B cell lymphoproliferative disorder that characteristically presents in older individuals. Small lymphocytic lymphoma (SLL) occurs when CLL cells infiltrate lymph nodes and other tissues but spare peripheral blood and bone marrow. Lymphomatoid papulosis (LyP) is an indolent cutaneous CD30+ lymphoproliferative disorder characterized by papules and nodules that develop and spontaneously regress over weeks to months. METHODS: An 84-year-old man with CLL who developed LyP is described...
May 15, 2018: Dermatology Online Journal
Alessia Giaquinta, Vincenzo Ardita, Ciro Ferrer, Clive B Beggs, Massimiliano Veroux, Matteo Barbante, Matteo Orrico, Piergiorgio Cao, Piefrancesco Veroux
PURPOSE: To assess early and midterm outcomes of iliac branch device (IBD) implantation without an aortic stent-graft for the treatment of isolated common iliac artery aneurysm (CIAA). METHODS: From December 2006 to June 2016, 49 isolated CIAAs in 46 patients were treated solely with an IBD at 7 vascular centers. Five patients were lost to follow-up, leaving 41 male patients (mean age 72.5±7.8 years) for analysis. Mean CIAA diameter was 39.1±10.5 mm (range 25-65)...
April 2018: Journal of Endovascular Therapy
Ramesh M Nataraja, Stephanie Khoo, Michael Ditchfield, Nathalie R Webb
BACKGROUND: Intussusception is a common, potentially life-threatening paediatric condition. Non-operative treatment with an air enema has been established as the clinical gold standard. There is no validated model for the training of this procedure. Our aim was to produce a novel air enema reduction simulator and validate its use as a training tool. METHODS: A low-cost paediatric intussusception air enema simulator was created. It was designed to include essential key clinical procedural steps...
August 22, 2018: ANZ Journal of Surgery
Marianne Uhre Jakobsen, Anders Gorst-Rasmussen, Helle H Eriksen, Jakob Stegger, Albert M Joensen, Anne Tjønneland, Jørn Dyerberg, Erik B Schmidt, Kim Overvad
BACKGROUND: The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism. OBJECTIVE: We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t. METHODS: A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years)...
2018: PloS One
Romolo J Gaspari, Alexandra Sanseverino, Timothy Gleeson
STUDY OBJECTIVE: We hypothesize that clinical failure rates will be lower in patients treated with point-of-care ultrasonography and incision and drainage compared with those who undergo incision and drainage after physical examination alone. METHODS: We performed a prospective randomized clinical trial of patients presenting with a soft tissue abscess at a large, academic emergency department. Patients presenting with an uncomplicated soft tissue abscess requiring incision and drainage were eligible for enrollment and randomized to treatment with or without point-of-care ultrasonography...
August 17, 2018: Annals of Emergency Medicine
Marc Dumas, Pauline Laly, Jérémy Gottlieb, Laetitia Vercellino, Frédéric Paycha, Martine Bagot, Barouyr Baroudjian, Isabelle Madelaine, Nicole Basset-Seguin, Pirayeh Eftekhari, Cécile Pagès, Céleste Lebbé, Frédéric Lioté
Targeted therapies have markedly improved the survival of patients with melanoma. We report the case of two patients with advanced melanoma controlled by long-term MEK inhibitor or combination of BRAF and MEK inhibitors, who developed fractures related to severe osteopenia. A 48-year-old woman was treated by pimasertib after the failure of two lines of chemotherapy, and a 42-year-old man was treated by an association of BRAFi (dabrafenib) and MEKi (trametinib) after the failure of one line of chemotherapy. During follow-up, both complained of buttock pain, revealing primary fractures of the pelvis and lumbar vertebra...
August 17, 2018: Melanoma Research
Michael B Brewer, David L Lau, James T Lee
Aortoiliac occlusive disease is a common cause of lower extremity claudication. Patients are typically found to have diminished femoral pulses and abnormal noninvasive vascular studies of the lower extremities. Isolated lesions of the internal iliac arteries are much less commonly treated but can cause similar claudication symptoms in the buttocks, hips, or thighs. Occlusive disease in the internal iliac artery is more challenging to diagnose because the lower extremity pulses and vascular studies can be normal...
August 14, 2018: Annals of Vascular Surgery
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