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Computational AND Spinal Cord

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https://www.readbyqxmd.com/read/29049229/neck-to-shoulder-pain-as-an-unusual-presentation-of-pulmonary-embolism-in-a-patient-with-cervical-spinal-cord-injury-a-case-report
#1
Dong Gyu Lee, Min Cheol Chang
RATIONALE: Information on referred pain can be helpful for diagnosing diseases of the visceral organs. Here, the authors report a patient with cervical spinal cord injury (SCI) who had referred pain at the right side from the neck to shoulder, as a presentation of pulmonary embolism (PE). PATIENT CONCERNS: A 55-year-old man with complete tetraplegia, due to cervical SCI after C5 and C6 vertebral body fracture, complained of right neck-to-shoulder pain (numerical scale rating: 6)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29044773/integrated-analysis-of-microrna-and-mrna-expression-profiles-in-the-rat-spinal-cord-under-inflammatory-pain-conditions
#2
Chien Cheng Liu, Jiin Tsuey Cheng, Tien Yui Li, Ping Heng Tan
Recent studies using microarray-based approaches have demonstrated that microRNAs (miRNAs) are involved in pain processing pathways. However, a significant proportion of computational predictions of miRNA targets are false-positive interactions. To increase the chance of identifying biologically relevant targets, we performed an integrated analysis of both miRNA and mRNA expression profiles in the rat spinal cord during complete Freund's adjuvant (CFA)-induced inflammatory pain. We generated miRNA and mRNA arrays from the same corresponding samples on Days 5 and 14 after CFA injection...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29042375/non-invasive-brain-stimulation-interventions-for-management-of-chronic-central-neuropathic-pain-a-scoping-review-protocol
#3
Mei Lin Chen, Lin Yao, Jennifer Boger, Kathryn Mercer, Benjamin Thompson, Ning Jiang
INTRODUCTION: Pain can affect people regardless of age, gender or ethnicity. Chronic central neuropathic pain (CCNP) is a debilitating condition that affects populations such as stroke survivors, amputees, spinal cord injury patients and patients with multiple sclerosis, with prevalence rates between 30% and 80%. This condition can be caused by a lesion or disease affecting the somatosensory system. CCNP is notoriously drug resistant, and few effective CCNP treatment or management strategies exist...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29034041/successful-endovascular-repair-of-mycotic-aortic-pseudoaneurysm-followed-by-aortoesophageal-fistula
#4
Seiichi Yamaguchi, Hideki Ueda, Hisanori Fujita, Shigeyasu Takeuchi
Mycotic aneurysm of the aorta is a rare, but life-threatening pathology. In recent years, endovascular stent graft placement has been introduced as an effective alternative for treating infected aortic aneurysms. A 64-year-old woman with a history of paraplegia due to spinal cord injury was referred to our institute with fever and blood-tinged sputum. Computed tomography (CT) scan showed an 11-cm pseudoaneurysm arising from the proximal descending aorta, which was normal 1 month ago at the previous CT scan...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032220/electodiagnostic-and-advanced-neuro-imaging-characterization-for-successful-treatment-of-a-spinal-extradural-arachnoid-cyst
#5
Tomoko Tanaka, Raja S Boddepalli, Douglas C Miller, Zongxian Cao, Vivek Sindhwani, Joan R Coates, Raghav Govindarajan, N Scott Litofsky
BACKGROUND: Spinal extradural arachnoid cysts (SEAC) are relatively uncommon. However, several large cysts have presented with spinal cord compression requiring surgical intervention. CASE DESCRIPTION: We report a patient with progressively enlarging SEAC causing worsening right S1 radiculopathy and gastrocnemius muscle atrophy. Electromyography (EMG) and nerve conduction studies (NCS) revealed an S1 motor radiculopathy. Serial magnetic resonance imaging (MRI) findings confirmed enlargement of the small cyst originating from the sacral thecal sac on the right while two smaller cyst on the left remained stable...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29031516/growth-of-adult-spinal-cord-in-knifefish-development-and-parametrization-of-a-distributed-model
#6
Iulian Ilieş, Rifat Sipahi, Günther K H Zupanc
The study of indeterminate-growing organisms such as teleost fish presents a unique opportunity for improving our understanding of central nervous tissue growth during adulthood. Integrating the existing experimental data associated with this process into a theoretical framework through mathematical or computational modeling provides further research avenues through sensitivity analysis and optimization. While this type of approach has been used extensively in investigations of tumor growth, wound healing, and bone regeneration, the development of nervous tissue has been rarely studied within a modeling framework...
October 12, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29019888/an-upper-cervical-cord-compression-secondary-to-occult-follicular-thyroid-carcinoma-metastases-successfully-treated-with-multiple-radioiodine-therapies-a-clinical-case-report
#7
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29017306/solitary-osteochondroma-presenting-as-a-dumbbell-tumor-compressing-the-cervical-spinal-cord
#8
Ju Hyung Lee, Sung Han Oh, Pyung Goo Cho, Eun Mi Han, Je Beom Hong
We report a case of a solitary osteochondroma as a dumbbell tumor compressing the spinal cord and its surgical strategy. The patient is a 16-year-old female with longstanding posterior neck pain and left arm abduction weakness. She was examined by plain X-ray, three-dimensional-computed tomography, magnetic resonance imaging, and vertebral angiography. The analyses indicated a calcified extradural mass compressing the cord in the C3-4 portion extending into the neural and vertebral foramen with eroded vertebral body...
September 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28993912/the-utility-of-magnetic-resonance-imaging-in-addition-to-computed-tomography-scans-in-the-evaluation-of-cervical-spine-injuries-a-study-of-obtunded-blunt-trauma-patients
#9
Bernard Puang Huh Lau, Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Pei Yi Nee, Kimberly-Anne Tan, Wah Tze Tan
PURPOSE: Evidence guiding the use of CT and MRI scans in blunt trauma patients who are obtunded remains controversial. This study aims to determine and predict if computed tomography (CT) scans alone can be performed without risking oversight of substantial injuries found on follow-up magnetic resonance imaging (MRI). METHODS: This is a retrospective cohort study of 63 blunt trauma patients with a Glasgow Coma Scale of < 8. Data were collated from electronic medical records and included patient demographics, premorbid mobility, mechanism of injury, suspected level of injury and neurological examination findings...
October 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28993035/outcomes-of-hybrid-procedure-for-type-b-aortic-dissection-with-an-aberrant-right-subclavian-artery
#10
Huanyu Ding, Songyuan Luo, Yuan Liu, Wenhui Huang, Minchun Jiang, Jie Li, Nianjin Xie, Xiaoping Fan, Ruixin Fan, Jianfang Luo
OBJECTIVE: To report our single-center experience of the hybrid procedure for type B aortic dissection (TBAD) with an aberrant right subclavian artery (ARSA) and the early to midterm outcomes in these patients. METHODS: From December 2011 to February 2016, 16 patients (12 males; median age, 51 years; range, 40-66 years) underwent thoracic endovascular aortic repair and extraanatomic bypass hybrid procedure for TBAD with an ARSA in our center. Demographics, coexisting medical conditions, imaging features, operation details, and follow-up outcomes of these patients were collected retrospectively and analyzed...
October 6, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28993019/a-modified-formula-for-dose-calculations-of-stereotactic-ablative-body-radiotherapy-for-non-small-cell-lung-cancer
#11
Yangsen Cao, Xiaofei Zhu, Yu Zhang, Chunshan Yu, Yongming Liu, Yongjian Sun, Zhitao Dai, Xueling Guo, Xiaoping Ju, Huojun Zhang
To provide a modified formula consistent with the Monte Carlo (MC) algorithm for dose calculations during stereotactic ablative body radiotherapy for non-small cell lung cancer. Seventy CyberKnife treatment plans were calculated and analyzed by MC and ray-tracing (RT) algorithms, separately. Parameters of treatment plans were compared, and those associated with differences of dose distributions were analyzed to establish a modified formula. Gross tumor volume and tumor tracking volume (TTV) were defined as the evident disease on the sequences of the window width and level of the lung and the mediastinum...
October 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28984777/anti-ma2-associated-limbic-encephalitis-with-coexisting-chronic-inflammatory-demyelinating-polyneuropathy-in-a-patient-with-non-hodgkin-lymphoma-a-case-report
#12
Weina Ju, Baochang Qi, Xu Wang, Yu Yang
RATIONALE: We report the rare case of a 74-year-old man with anti-Ma2-associated paraneoplastic neurologic syndrome (PNS), and review and analyze the clinical manifestations, diagnosis, and treatment of the disease. PATIENT CONCERNS: The patient presented with a 5-month history of muscle weakness, progressive body aches, and weakness and numbness in both lower extremities. Before his hospitalization, he had experienced cognitive function decline; ptosis, inward gaze, and vertical gaze palsy in the right eye; and occasional visual hallucinations...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28970100/early-intensive-hand-rehabilitation-is-not-more-effective-than-usual-care-plus-one-to-one-hand-therapy-in-people-with-sub-acute-spinal-cord-injury-hands-on-a-randomised-trial
#13
Lisa A Harvey, Sarah A Dunlop, Leonid Churilov, Mary P Galea
QUESTION: What is the effect of adding an intensive task-specific hand-training program involving functional electrical stimulation to a combination of usual care plus three 15-minute sessions per week of one-to-one hand therapy in people with sub-acute tetraplegia? DESIGN: A parallel group, randomised, controlled trial. Participants were randomly assigned (1:1) via a computer-generated concealed block randomisation procedure to either a control or experimental intervention...
October 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28962027/intraoperative-spinal-navigation-for-the-removal-of-intradural-tumors-technical-notes
#14
Roberto Stefini, Stefano Peron, Jaime Mandelli, Elena Bianchini, Paolo Roccucci
BACKGROUND: In recent years, spinal surgery has incorporated the many advantages of navigation techniques to facilitate the placement of pedicle screws during osteosynthesis, mainly for degenerative diseases. However, spinal intradural tumors are not clearly visible by intraoperative fluoroscopy or computed tomography scans, thereby making navigation necessary. OBJECTIVE: To evaluate the use of spinal navigation for the removal of intradural and spinal cord tumors using spinal magnetic resonance imaging (MRI) merged with intraoperative 3-dimensional (3-D) fluoro images...
August 5, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28961100/an-mri-compatible-hydrodynamic-simulator-of-cerebrospinal-fluid-motion-in-the-cervical-spine
#15
Suraj Thyagaraj, Soroush H Pahlavian, Lucas R Sass, Francis Loth, Morteza Vatani, Jao-Won Choi, R Shane Tubbs, Daniel Giese, Jan-Robert Kroger, Alexander C Bunck, Bryn A Martin
GOAL: Develop and test an MRI-compatible hydrodynamic simulator of cerebrospinal fluid (CSF) motion in the cervical spinal subarachnoid space. Four anatomically realistic subject-specific models were created based on a 22-year-old healthy volunteer and a five-year-old patient diagnosed with Chiari I malformation. METHODS: The in vitro models were based on manual segmentation of high-resolution T2-weighted MRI of the cervical spine. Anatomically realistic dorsal and ventral spinal cord nerve rootlets (NR) were added...
September 26, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28961092/from-brain-to-body-new-technologies-improve-paralyzed-patients-quality-of-life
#16
Mary Bates
Paralysis, whether caused by spinal cord injury, neurodegenerative disease, or other factors, poses a host of issues for patients. These include not just the inability to move parts of their bodies but potential problems with communication and bladder control as well. Fortunately, the last decade has seen promising technology advances to address these concerns. Although most are still in the research stage, these technologies-including brain-computer interfaces (BCIs), exoskeletons, and robotics-may one day improve the lives of people with paralysis...
September 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28961064/spinal-circuits-for-touch-pain-and-itch
#17
Stephanie C Koch, David Acton, Martyn Goulding
The exteroceptive somatosensory system is important for reflexive and adaptive behaviors and for the dynamic control of movement in response to external stimuli. This review outlines recent efforts using genetic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneous somatosensory modalities of touch, itch, and pain. Recent studies have revealed an underlying modular architecture in which nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly defined interneuron cell types...
September 27, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/28948168/towards-rehabilitation-robotics-off-the-shelf-bci-control-of-anthropomorphic-robotic-arms
#18
Alkinoos Athanasiou, Ioannis Xygonakis, Niki Pandria, Panagiotis Kartsidis, George Arfaras, Kyriaki Rafailia Kavazidi, Nicolas Foroglou, Alexander Astaras, Panagiotis D Bamidis
Advances in neural interfaces have demonstrated remarkable results in the direction of replacing and restoring lost sensorimotor function in human patients. Noninvasive brain-computer interfaces (BCIs) are popular due to considerable advantages including simplicity, safety, and low cost, while recent advances aim at improving past technological and neurophysiological limitations. Taking into account the neurophysiological alterations of disabled individuals, investigating brain connectivity features for implementation of BCI control holds special importance...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28948166/computer-assessed-preference-based-quality-of-life-in-patients-with-spinal-cord-injury
#19
Enea Parimbelli, Caterina Pistarini, Gabriella Fizzotti, Carla Rognoni, Giampiero Olivieri, Silvana Quaglini
OBJECTIVES: Our aims were to (1) measure quality of life (QoL) in spinal cord injury (SCI) patients using different methods and analyze differences; (2) enable targeted treatments by identifying variables that affect QoL; and (3) provide decision-makers with useful data for cost-utility analyses in SCI population. METHODS: Seventy-one participants were enrolled. The computer-based tool UceWeb was used to elicit QoL in terms of utility coefficients, through the standard gamble, time trade-off, and rating scale methods...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28934801/increasing-rates-of-imaging-in-failed-back-surgery-syndrome-patients-implications-for-spinal-cord-stimulation
#20
S Harrison Farber, Jing L Han, Frank W Petraglia Iii, Robert Gramer, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Jeffrey R Petrella, Shivanand P Lad
BACKGROUND: Failed back surgery syndrome (FBSS) has a high incidence following spinal surgery, is notoriously refractory to treatment, and results in high health care utilization. Spinal cord stimulation (SCS) is a well-accepted modality for pain relief in this population; however, until recently magnetic resonance imaging (MRI) was prohibited due to risk of heat conduction through the device. OBJECTIVES: We examined trends in imaging use over the past decade in patients with FBSS to determine its impact on health care utilization and implications for patients receiving SCS...
September 2017: Pain Physician
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