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Computational AND Spinal Cord

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https://www.readbyqxmd.com/read/28092564/static-vs-dynamic-decoding-algorithms-in-a-non-invasive-body-machine-interface
#1
Ismael Seanez-Gonzalez, Camilla Pierella, Ali Farshchiansadegh, Elias Barry Thorp, Farnaz Abdollahi, Jessica P Pedersen, Ferdinando A Mussa-Ivaldi
In this study, we consider a non-invasive bodymachine interface that captures body motions still available to people with spinal cord injury (SCI) and maps them into a set of signals for controlling a computer user interface while engaging in a sustained level of mobility and exercise. We compare the effectiveness of two decoding algorithms that transform a highdimensional body-signal vector into a lower dimensional control vector on 6 subjects with high-level SCI and 8 controls. One algorithm is based on a static map from current body signals to the current value of the control vector set through principal component analysis (PCA), the other on dynamic mapping a segment of body signals to the value and the temporal derivatives of the control vector set through a Kalman filter...
December 15, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28065638/iterative-metal-artefact-reduction-in-ct-can-dedicated-algorithms-improve-image-quality-after-spinal-instrumentation
#2
J Aissa, C Thomas, L M Sawicki, J Caspers, P Kröpil, G Antoch, J Boos
AIM: To investigate the value of dedicated computed tomography (CT) iterative metal artefact reduction (iMAR) algorithms in patients after spinal instrumentation. MATERIALS AND METHODS: Post-surgical spinal CT images of 24 patients performed between March 2015 and July 2016 were retrospectively included. Images were reconstructed with standard weighted filtered back projection (WFBP) and with two dedicated iMAR algorithms (iMAR-Algo1, adjusted to spinal instrumentations and iMAR-Algo2, adjusted to large metallic hip implants) using a medium smooth kernel (B30f) and a sharp kernel (B70f)...
January 5, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28059798/sporadic-cases-with-novel-mutations-and-pedigree-in-hereditary-leukoencephalopathy-with-axonal-spheroids
#3
Liyong Wu, Jia Liu, Longze Sha, Xianling Wang, Jieying Li, Jing Dong, Jianping Jia
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant hereditary disease, featured by cerebral white matter degeneration with demyelination and axonal spheroids. We collected three gene-confirmed HDLS cases in our neurodegenerative clinic. Two HDLS cases were sporadic with novel mutations, while another case had a family history with previously described mutations. All three cases suffered memory problems with white matter lesions and pyramid signs. No obvious clinical differences were observed between sporadic and familial HDLS cases...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28058831/peptide-tethered-hydrogel-scaffold-promotes-recovery-from-spinal-cord-transection-via-synergism-with-mesenchymal-stem-cells
#4
Li-Ming Li, Min Han, Xinchi Jiang, Xianzhen Yin, Fu Chen, Tian-Yuan Zhang, Hao Ren, Jiwen Zhang, Zhong Chen, Tingjun Hou, HongWei Ouyang, Yasuhiko Tabata, Youqing Shen, Jian-Qing Gao
Spinal cord injury (SCI) is one of the most devastating injuries. Treatment strategies for SCI are required to overcome comprehensive issues. Implantation of biomaterial scaffolds and stem cells has been demonstrated to be promising strategies. However, a comprehensive recovery effect is difficult to achieve. In the comprehensive treatment process, the specific roles of the implanted scaffolds and of stem cells in combined strategy are usually neglected. In this study, a peptide-modified scaffold is developed based on hyaluronic acid and an adhesive peptide PPFLMLLKGSTR...
January 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28048554/th-ab-202-03-a-novel-tool-for-computing-deliverable-doses-in-dynamic-mlc-tracking-treatments
#5
M Fast, C Kamerling, S Crijns, M Menten, S Nill, B Raaymakers, U Oelfke
PURPOSE: In tracked dynamic multi-leaf collimator (MLC) treatments, segments are continuously adapted to the target centroid motion in beams-eye-view. On-the-fly segment adaptation, however, potentially induces dosimetric errors due to the finite MLC leaf width and non-rigid target motion. In this study, we outline a novel tool for computing the 4d dose of lung SBRT plans delivered with MLC tracking. METHODS: The following automated workflow was developed: A) centroid tracking, where the initial segments are morphed to each 4dCT phase based on the beams-eye-view GTV shift (followed by a dose calculation on each phase); B) re-optimized tracking, in which all morphed initial plans from (A) are further optimised ("warm-started") in each 4dCT phase using the initial optimisation parameters but phase-specific volume definitions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048228/su-f-p-26-study-of-radiation-dose-evaluation-for-organs-at-risk-using-mri-in-intensity-modulated-radiation-therapy-for-nasopharyngeal-carcinoma
#6
G Gong, Y Guo, Y Yin
PURPOSE: To study the contour and dosimetric feature of organs at risk (OARs) applying magnetic resonance imaging (MRI) images in intensity modulated radiation therapy (IMRT) of nasopharyngeal carcinoma (NPC) compared to computed tomography (CT) images. METHODS: 35 NPC patients was selected into this trail. CT simulation with non-contrast and contrast enhanced scan, MRI simulation with non-contrast and contrast enhanced T1, T2 and diffusion weighted imaging were achieved sequentially...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047696/su-d-brc-05-effects-of-motion-and-variable-rbe-in-a-lung-patient-treated-with-passively-scattered-protons
#7
D Mirkovic, U Titt, P Yepes, R Mohan
PURPOSE: To evaluate effects of motion and variable relative biological effectiveness (RBE) in a lung cancer patient treated with passively scattered proton therapy using dose volume histograms associated with patient dose computed using three different methods. METHODS: A proton treatment plan of a lung cancer patient optimized using clinical treatment planning system (TPS) was used to construct a detailed Monte Carlo (MC) model of the beam delivery system and the patient specific aperture and compensator...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047535/su-f-i-38-patient-organ-specific-dose-assessment-in-coronary-ct-angiograph-using-voxellaized-volume-dose-index-in-monte-carlo-simulation
#8
Mohammadi Gh Fallal, Alam N Riyahi, Gh Graily, R Paydar
PURPOSE: Clinical use of multi detector computed tomography(MDCT) in diagnosis of diseases due to high speed in data acquisition and high spatial resolution is significantly increased. Regarding to the high radiation dose in CT and necessity of patient specific radiation risk assessment, the adoption of new method in the calculation of organ dose is completely required and necessary. In this study by introducing a conversion factor, patient organ dose in thorax region based on CT image data using MC system was calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047490/su-f-j-90-effects-of-optimization-cost-function-on-ventilation-in-sbrt-of-nsclc
#9
I Mihaylov, K Latifi, M De Ornelas-Couto, E Moros, G Zhang
PURPOSE: To explore the effects of dose-volume (Dvh) and dose-mass (Dmh) inverse optimization approaches on the lung ventilation for SBRT in NSCLC. METHODS: Six cases were studied. For each case ventilation was computed on voxel-by-voxel basis, derived from the time-resolved (4D) CT scans. Ventilation is defined as voxel volume change between full inspiration and full expiration, divided by voxel volume. The ventilation volume was mapped to full expiration phase...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047350/su-f-t-256-4d-imrt-planning-using-an-early-prototype-gpu-enabled-eclipse-workstation
#10
A Hagan, A Modiri, M Svatos, A Sawant
PURPOSE: True 4D IMRT planning, based on simultaneous spatiotemporal optimization has been shown to significantly improve plan quality in lung radiotherapy. However, the high computational complexity associated with such planning represents a significant barrier to widespread clinical deployment. We introduce an early prototype GPU-enabled Eclipse workstation for inverse planning. To our knowledge, this is the first GPUintegrated Eclipse system demonstrating the potential for clinical translation of GPU computing on a major commercially-available TPS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047301/tu-ab-202-10-how-effective-are-current-atlas-selection-methods-for-atlas-based-auto-contouring-in-radiotherapy-planning
#11
D Peressutti, B Schipaanboord, J van Soest, T Lustberg, W van Elmpt, T Kadir, A Dekker, M Gooding
PURPOSE: To investigate the effectiveness of atlas selection methods for improving atlas-based auto-contouring in radiotherapy planning. METHODS: 275 H&N clinically delineated cases were employed as an atlas database from which atlases would be selected. A further 40 previously contoured cases were used as test patients against which atlas selection could be performed and evaluated. 26 variations of selection methods proposed in the literature and used in commercial systems were investigated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047269/tu-h-campus-iep1-04-combined-organ-dose-for-digital-subtraction-angiography-and-computed-tomography-using-monte-carlo-simulation
#12
D Sakabe, T Ohno, F Araki, M Hashida, Y Funama
PURPOSE: The purpose of this study was to evaluate the combined organ dose of digital subtraction angiography (DSA) and computed tomography (CT) using a Monte Carlo (MC) simulation on the abdominal intervention. METHODS: The organ doses for DSA and CT were obtained with MC simulation and actual measurements using fluorescent-glass dosimeters at 7 abdominal portions in an Alderson-Rando phantom. DSA was performed from three directions: posterior anterior (PA), right anterior oblique (RAO), and left anterior oblique (LAO)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047039/su-f-t-623-dosimetric-and-radiobiological-comparison-of-conventional-and-monte-carlo-treatment-plans-of-lung-tumors-using-sbrt
#13
S Stathakis, P Mavroidis, B Tuazon, D Defoor, N Kirby, N Papanikolaou
PURPOSE: This study aims at estimating the dosimetric differences of Pinnacle and Monte Carlo (MC) calculation algorithms in computing the dose distributions in lung cancer SBRT cases. Furthermore, to interpret the dosimetric findings into expected tissue response rates in order to estimate their clinical impact. METHODS: 17 patients were studied and for each one, two treatment plans (one from Pinnacle and one MC) were created. The structures that were used for the optimization were: PTV, ipsilateral and contralateral lungs, spinal cord, heart, esophagus and stomach...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046412/we-ab-209-12-quasi-constrained-multi-criteria-optimization-for-automated-radiation-therapy-treatment-planning
#14
W T Watkins, J V Siebers
PURPOSE: To introduce quasi-constrained Multi-Criteria Optimization (qcMCO) for unsupervised radiation therapy optimization which generates alternative patient-specific plans emphasizing dosimetric tradeoffs and conformance to clinical constraints for multiple delivery techniques. METHODS: For N Organs At Risk (OARs) and M delivery techniques, qcMCO generates M(N+1) alternative treatment plans per patient. Objective weight variations for OARs and targets are used to generate alternative qcMCO plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044436/evaluation-of-a-self-efficacy-enhancement-program-to-prevent-pressure-ulcers-in-patients-with-a-spinal-cord-injury
#15
Jung Yoon Kim, Eunhee Cho
AIM: This study developed a self-efficacy enhancement program and evaluated its effects on the self-care behaviors, self-care knowledge, and self-efficacy regarding pressure ulcer prevention in patients with a spinal cord injury. METHODS: This was a multicenter randomized controlled trial. Six hospitals were invited to recruit patients with a spinal cord injury who were undergoing rehabilitation after receiving acute treatment. These hospitals were randomly allocated into experimental (three hospitals) or control (three hospitals) groups and 47 patients participated (24 in the experimental group and 23 in the control group)...
January 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28034635/patient-specific-bone-mineral-density-distribution-in-the-tibia-of-individuals-with-chronic-spinal-cord-injury-derived-from-multi-slice-peripheral-quantitative-computed-tomography-pqct-a-cross-sectional-study
#16
Sylvie Coupaud, Magnus K Gislason, Mariel Purcell, Keisuke Sasagawa, K Elizabeth Tanner
BACKGROUND: The high risk of fracture associated with chronic spinal cord injury (SCI) is attributed to extensive disuse-related bone loss in previously weight-bearing long bones. Changes in bone mineral density (BMD) after SCI have been documented extensively for the epiphyses of the tibia and femur, fracture-prone sites in this patient group. Less attention has been given to patterns of cortical bone loss in the diaphyses, but variability in BMD distributions throughout the long bones may contribute to some patients' increased susceptibility to shaft fractures in chronic SCI...
December 26, 2016: Bone
https://www.readbyqxmd.com/read/28033509/atlas-based-segmentation-in-breast-cancer-radiotherapy-evaluation-of-specific-and-generic-purpose-atlases
#17
Delia Ciardo, Marianna Alessandra Gerardi, Sabrina Vigorito, Anna Morra, Veronica Dell'acqua, Federico Javier Diaz, Federica Cattani, Paolo Zaffino, Rosalinda Ricotti, Maria Francesca Spadea, Marco Riboldi, Roberto Orecchia, Guido Baroni, Maria Cristina Leonardi, Barbara Alicja Jereczek-Fossa
OBJECTIVES: Atlas-based automatic segmentation (ABAS) addresses the challenges of accuracy and reliability in manual segmentation. We aim to evaluate the contribution of specific-purpose in ABAS of breast cancer (BC) patients with respect to generic-purpose libraries. MATERIALS AND METHODS: One generic-purpose and 9 specific-purpose libraries, stratified according to type of surgery and size of thorax circumference, were obtained from the computed tomography of 200 BC patients...
December 26, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28033295/a-sewing-needle-in-contact-with-the-cervical-dura-mater-and-vertebral-artery-a-case-report
#18
Arizumi Fumihiro, Inoue Shinichi, Tachibana Toshiya, Maruo Keishi, Yoshiya Shinichi
RATIONALE: Although cervical foreign bodies have been previously reported, the report of a needle in the cervical spinal cord is rare. Herein, we report a rare case of a sewing needle in contact with the cervical dura mater and vertebral artery. PATIENTS CONCERNS: A 47-year-old man presented with discomfort in the posterior region of his neck. Approximately 2 years before admission, he suffered a stiff neck and had stabbed the posterior region of his neck with a sewing needle...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28033285/migration-of-titanium-cable-into-spinal-cord-and-spontaneous-c2-and-c3-fusion-case-report-of-possible-causes-of-fatigue-failure-after-posterior-atlantoaxial-fixation
#19
Huibo Li, Jigang Lou, Hao Liu
INTRODUCTION: Atlantoaxial instability is a common and serious injury of the upper cervical spine. Brooks' procedure is widely used to reconstruct the unstable atlantoaxial joint. The migration into spinal cord of titanium cable and spontaneous fusion between C2 and C3 has been little reported and the management of such a patient is difficult. We describe an unusual case of fatigue failure of posterior titanium atlantoaxial cable fixation with migration into the spinal cord and spontaneous fusion between C2 and C3...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28026777/local-and-remote-cooperation-with-virtual-and-robotic-agents-a-p300-bci-study-in-healthy-and-people-living-with-spinal-cord-injury
#20
Emmanuele Tidoni, Mohammad Abu-Alqumsan, Daniele Leonardis, Christoph Kapeller, Gabriele Fusco, Christoph Guger, Cristoph Hintermueller, Angelika Peer, Antonio Frisoli, Franco Tecchia, Massimo Bergamasco, Salvatore M Aglioti
The development of technological applications that allow people to control and embody external devices within social interaction settings represents a major goal for current and future brain-computer interface (BCI) systems.
December 23, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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