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https://www.readbyqxmd.com/read/29441100/dose-volume-analysis-of-target-volume-and-critical-structures-in-computed-tomography-image-based-multicatheter-high-dose-rate-interstitial-brachytherapy-for-head-and-neck-cancer
#1
Hironori Akiyama, Tibor Major, Csaba Polgár, Zoltán Takácsi-Nagy
Purpose: To evaluate dose-volume relationships of target volume and critical structures in computed tomography (CT) image-based brachytherapy for head and neck cancer. Material and methods: Thirty-seven patients with mobile tongue, floor of mouth, and base of tongue cancer treated with brachytherapy (post-operative alone and as a boost after external beam radiotherapy [EBRT], or definitive alone or as a boost after EBRT) were selected. Treatment plans were made using post-implant CT images...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29430662/on-the-feasibility-of-automatically-selecting-similar-patients-in-highly-individualized-radiotherapy-dose-reconstruction-for-historic-data-of-pediatric-cancer-survivors
#2
Marco Virgolin, Irma W E M van Dij, Jan Wiersma, Cécile M Ronckers, Cees Witteveen, Arjan Bel, Tanja Alderliesten, Peter A N Bosman
PURPOSE: The aim of this study is to establish the first step towards a novel and highly individualized 3D dose distribution reconstruction method, based on CT scans and organ delineations of recently treated patients. Specifically, the feasibility of automatically selecting the CT scan of a recently treated childhood cancer patient who is similar to a given historically treated child who suffered from Wilms' tumor is assessed. METHODS: A cohort of 37 recently treated children between 2 and 6 years old is considered...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29422366/ossified-extradural-en-plaque-meningioma-of-the-cervical-spine
#3
Koichiro Sakamoto, Satoshi Tsutsumi, Senshu Nonaka, Takamoto Suzuki, Hisato Ishii, Masanori Ito, Yukimasa Yasumoto
A 57-year-old woman sustained gradually progressive sensorimotor disturbance in the left upper extremity for one year. Neurological examination found a diminished sensation below the left C7 dermatome and reduced strength in the left interosseous muscles. Computed tomography of the cervical spine revealed a high density mass at C7, in the left dorsal part of the spinal canal. Magnetic resonance imaging found an enhancing, en-plaque tumor at C6-T1, involving a non-enhancing part, and considerable compression of the spinal cord...
February 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29417427/computer-assistive-technology-and-associations-with-quality-of-life-for-individuals-with-spinal-cord-injury-a-systematic-review
#4
REVIEW
Valéria Baldassin, Helena Eri Shimizu, Emerson Fachin-Martins
STUDY DESIGN: Systematic review. OBJECTIVE: The purpose of the study was to identify and organize evidence regarding quality of life influenced by assistive technology related to computers for people with traumatic and non-traumatic spinal cord injury (SCI). SETTING: Distrito Federal, Brazil. METHODS: A search strategy was conducted on the PubMed, PEDro, LILACS, PsycINFO, and SCIELO. All types of study designs considering assistive technology to improve quality of life for individuals with SCI were included...
February 7, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29411711/microstructure-and-in-vivo-characterization-of-multi-channel-nerve-guidance-scaffolds
#5
Kendell Pawelec, Jacob Koffler, Dena Shahriari, Angelica Rose Galvan, Mark Tuszynski, Jeff Sakamoto
In a previous study, we demonstrated a novel manufacturing approach to fabricate multi-channel scaffolds (MCS) for use in spinal cord injuries (SCI). In the present study, we extended similar materials processing technology to fabricate significantly longer (5X) porous poly caprolactone (PCL) MCS and evaluated their efficacy in 1 cm sciatic peripheral nerve injury (PNI) model. Due to the increase in MCS dimensions and the challenges that may arise in a longer nerve gap model, microstructural characterization involved MCS wall permeability to assess nutrient flow, topography to understand cell integration, and microstructural uniformity to evaluate the potential for homogeneous linear axon guidance...
February 7, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29411052/-spinal-cysts-diagnostic-workup-and-therapy
#6
REVIEW
A Simgen
CLINICAL ISSUE: Spinal cysts can be classified as meningeal, not meningeal, and tumor-associated cysts. Due to the widespread availability of high-resolution computed tomography and magnet resonance imaging, spinal cysts can be detected with high sensitivity these days. Concerning the variety of potential cystic differential diagnoses, a precise classification is difficult and can often only be realized after surgical inspection or histological examination. PRACTICAL RECOMMENDATIONS: Spinal cysts are generally incidental findings during a routine diagnostic workup and need no further therapy...
February 2018: Der Radiologe
https://www.readbyqxmd.com/read/29403246/surgical-management-of-c-type-subaxial-cervical-fractures-using-cervical-traction-followed-by-anterior-cervical-discectomy-and-fusion-within-12-h-after-the-trauma
#7
Pasquale Donnarumma, Vincenzo Bozzini, Gaetano Rizzi, Arturo Berardi, Gaetano Merlicco
Study Design: This was a retrospective cohort study. Objective: To report our 10-year experience of closed reduction using Crutchfield traction followed by anterior cervical discectomy and fusion within 12 h from injury for C-type subaxial cervical fractures (according to the AOSpine classification system). Methods: Clinical records and neuroimaging were retrospectively reviewed. Surgical details were provided. Results: A total of 22 patients were included in the study...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29399061/neuroprotective-effect-of-local-hypothermia-in-a-computer-controlled-compression-model-in-minipig-correlation-of-tissue-sparing-along-the-rostro-caudal-axis-with-neurological-outcome
#8
Stefania Gedrova, Jan Galik, Martin Marsala, Monika Zavodska, Jaroslav Pavel, Igor Sulla, Miroslav Gajdos, Imrich Lukac, Jozef Kafka, Valent Ledecky, Igor Sulla, Martina Karasova, Peter Reichel, Alexandra Trbolova, Igor Capik, Viktoria Lukacova, Katarina Bimbova, Maria Bacova, Andrea Stropkovska, Nadezda Lukacova
This study investigated the neuroprotective efficacy of local hypothermia in a minipig model of spinal cord injury (SCI) induced by a computer-controlled impactor device. The tissue integrity observed at the injury epicenter, and up to 3 cm cranially and caudally from the lesion site correlated with motor function. A computer-controlled device produced contusion lesions at L3 level with two different degrees of tissue sparing, depending upon pre-set impact parameters (8N- and 15N-force impact). Hypothermia with cold (4°C) saline or Dulbecco's modified Eagle's medium (DMEM)/F12 culture medium was applied 30 min after SCI (for 5 h) via a perfusion chamber (flow 2 ml/min)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398364/graded-arrays-of-spinal-and-supraspinal-v2a-interneuron-subtypes-underlie-forelimb-and-hindlimb-motor-control
#9
Marito Hayashi, Christopher A Hinckley, Shawn P Driscoll, Niall J Moore, Ariel J Levine, Kathryn L Hilde, Kamal Sharma, Samuel L Pfaff
The spinal cord contains neural networks that enable regionally distinct motor outputs along the body axis. Nevertheless, it remains unclear how segment-specific motor computations are processed because the cardinal interneuron classes that control motor neurons appear uniform at each level of the spinal cord. V2a interneurons are essential to both forelimb and hindlimb movements, and here we identify two major types that emerge during development: type I neurons marked by high Chx10 form recurrent networks with neighboring spinal neurons and type II neurons that downregulate Chx10 and project to supraspinal structures...
January 31, 2018: Neuron
https://www.readbyqxmd.com/read/29397209/update-of-the-systematic-review-of-palliative-radiation-therapy-fractionation-for-bone-metastases
#10
Shayna E Rich, Ronald Chow, Srinivas Raman, K Liang Zeng, Stephen Lutz, Henry Lam, Maurício F Silva, Edward Chow
PURPOSE: Radiation therapy is an effective modality for pain management of symptomatic bone metastases. We update the previous meta-analyses of randomized trials comparing single fraction to multiple fractions of radiation therapy in patients with uncomplicated bone metastases. METHODS: A literature search was conducted in Ovid Medline, Embase, and Cochrane Central Register. Ten new randomized trials were identified since 2010, five with adequate and appropriate data for inclusion, resulting in a total of 29 trials that were analyzed...
January 31, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29395428/institutional-experience-with-the-zenith-fenestrated-aortic-stent-graft
#11
S Keisin Wang, Ashley R Gutwein, Alok K Gupta, Gary W Lemmon, Alan P Sawchuk, Raghu L Motaganahalli, Michael P Murphy, Andres Fajardo
OBJECTIVE: The Zenith Fenestrated (ZFEN; Cook Medical, Bloomington, Ind) aortic stent graft system was approved for commercial use by the Food and Drug Administration in April 2012. We report our single-center experience of 100 consecutive patients treated with the ZFEN platform from October 2012 to March 2017. METHODS: A retrospective review of our prospectively maintained fenestrated endovascular aneurysm repair (FEVAR) database at a tertiary care academic institution located in the Midwest United States was performed for descriptive analysis...
January 27, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29394937/side-effects-of-ct-guided-implantation-of-125i-seeds-for-recurrent-malignant-tumors-of-the-head-and-neck-assisted-by-3d-printing-non-co-planar-template
#12
Yuliang Jiang, Zhe Ji, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Shuhua Wei, Weiyan Li, Kai Liu, Jinghua Lei, Junjie Wang
BACKGROUND: For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D-PNCT) for computed tomography (CT)-guided radioactive 125I seed (RIS) implantation in recurrent cancer of the head and neck. METHODS: Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D-PNCT-assisted RIS implantation...
February 3, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29392099/improving-c1-c2-complex-fusion-rates-an-alternate-approach
#13
REVIEW
Samer S Ghostine, Paul E Kaloostian, Christ Ordookhanian, Sean Kaloostian, Parham Zarrini, Terrence Kim, Stephen Scibelli, Scott J Clark-Schoeb, Srinath Samudrala, Carl Lauryssen, Amandip S Gill, Patrick J Johnson
The surgical repair of atlantoaxial instabilities (AAI) presents complex and unique challenges, originating from abnormalities and/or trauma within the junction regions of the C1-C2 atlas-axis, to surgeons. When this region is destabilized, surgical fusion becomes of key importance in order to prevent spinal cord injury. Several techniques can be utilized to provide for the adequate fusion of the atlantoaxial construct. Nevertheless, many individuals have less than ideal rates of fusion, below 35%-40%, which also involves the C2 nerve root being sacrificed...
November 29, 2017: Curēus
https://www.readbyqxmd.com/read/29390464/vascular-spinal-cord-obstruction-associated-with-superior-vena-cava-syndrome-a-case-report-and-literature-review
#14
Xiaoling Zhang, Xinyuan Li, Meihong Meng, Jie Cao, Xiaonan Song, Kangding Liu, Shaokuan Fang
RATIONALE: Superior vena cava syndrome (SVCS) is the obstruction of blood flow through the SVC, causing complete or partial blockade of the collateral circulation of returning venous blood. SVCS is frequently presented with facial, neck, trunk, and upper limbs swelling and so on. However, to the best of our knowledge, the obstruction of the venous return in the spinal veins is rarely a manifestation of SVCS. PATIENT CONCERNS: We presented a rare case of a 52-year-old male patient with 2-month history of progressive right upper limb numbness and swelling and 10-day history of extremities malfunctioning...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386408/transcutaneous-spinal-direct-current-stimulation-of-the-lumbar-and-sacral-spinal-cord-a-modelling-study
#15
Sofia Rita Cardoso Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede Alves Carvalho, Pedro C Miranda
Our aim was to perform a computational study of the electric field (E-field) generated by transcutaneous spinal direct current stimulation (tsDCS) applied over the thoracic, lumbar and sacral spinal cord, in order to assess possible neuromodulatory effects on spinal cord circuitry related with lower limb functions. Approach. A realistic volume conductor model of the human body consisting of 14 tissues was obtained from available databases. Rubber pad electrodes with a metallic connector and a conductive gel layer were modelled...
February 1, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29382028/intraoperative-conversion-of-artificial-cervical-disc-replacement-to-anterior-cervical-discectomy-and-fusion-for-iatrogenic-fracture-a-rare-case-report
#16
Bei-Yu Wang, Ting-Kui Wu, Hao Liu, Yu-Xiao Deng, Chen Ding
RATIONALE: Artificial cervical disc replacement (ACDR) has been reported to be an effective and safe surgical treatment for cervical spondylosis. However, iatrogenic fracture during ACDR surgery has rarely been reported. Considering its infrequency, we report a rare clinical case, with the aim of sharing our experience and exploring when to convert ACDR to fusion intraoperatively. PATIENTS CONCERNS: A 47-year-old woman felt neck pain with weakness and numbness in both upper limbs for 5 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381748/common-neural-structures-activated-by-epidural-and-transcutaneous-lumbar-spinal-cord-stimulation-elicitation-of-posterior-root-muscle-reflexes
#17
Ursula S Hofstoetter, Brigitta Freundl, Heinrich Binder, Karen Minassian
Epidural electrical stimulation of the lumbar spinal cord is currently regaining momentum as a neuromodulation intervention in spinal cord injury (SCI) to modify dysregulated sensorimotor functions and augment residual motor capacity. There is ample evidence that it engages spinal circuits through the electrical stimulation of large-to-medium diameter afferent fibers within lumbar and upper sacral posterior roots. Recent pilot studies suggested that the surface electrode-based method of transcutaneous spinal cord stimulation (SCS) may produce similar neuromodulatory effects as caused by epidural SCS...
2018: PloS One
https://www.readbyqxmd.com/read/29379140/operation-of-a-p300-based-brain-computer-interface-in-patients-with-duchenne-muscular-dystrophy
#18
Kota Utsumi, Kouji Takano, Yoji Okahara, Tetsuo Komori, Osamu Onodera, Kenji Kansaku
A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it has not been tested systematically in Duchenne muscular dystrophy (DMD), which is a severe type of muscular dystrophy due to the loss of dystrophin and is often accompanied by progressive muscle weakness and wasting...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378445/real-time-closed-loop-functional-electrical-stimulation-control-of-muscle-activation-with-evoked-electromyography-feedback-for-spinal-cord-injured-patients
#19
Zhan Li, David Guiraud, David Andreu, Anthony Gelis, Charles Fattal, Mitsuhiro Hayashibe
Functional electrical stimulation (FES) is a neuroprosthetic technique to help restore motor function of spinal cord-injured (SCI) patients. Through delivery of electrical pulses to muscles of motor-impaired subjects, FES is able to artificially induce their muscle contractions. Evoked electromyography (eEMG) is used to record such FES-induced electrical muscle activity and presents a form of [Formula: see text]-wave. In order to monitor electrical muscle activity under stimulation and ensure safe stimulation configurations, closed-loop FES control with eEMG feedback is needed to be developed for SCI patients who lose their voluntary muscle contraction ability...
December 25, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/29370354/systematic-evaluation-of-collateral-pathways-to-the-artery-of-adamkiewicz-using-computed-tomography
#20
Kunihiro Yoshioka, Ryoichi Tanaka, Hidenobu Takagi, Yuta Ueyama, Tsuyoshi Sugawara, Takuya Chiba, Kazumasa Arakita, Joanne D Schuijf
OBJECTIVES: Preoperative identification of the artery of Adamkiewicz can help prevent postoperative spinal cord injury in patients undergoing thoracic and thoraco-abdominal aortic aneurysm repair. Although several studies have shown the feasibility of evaluating the artery of Adamkiewicz using multidetector row computed tomography (MDCT), no detailed investigations regarding the collateral circulation to the artery of Adamkiewicz have been performed. The purpose of this study was to investigate the collateral circulation to the artery of Adamkiewicz using MDCT in patients with thoracic and thoraco-abdominal aortic aneurysms...
January 22, 2018: European Journal of Cardio-thoracic Surgery
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