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Gastric cancer hepatitis c

Haruyoshi Tanaka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Naoki Iwata, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Michitaka Fujiwara, Yukiko Niwa, Yasuhiro Kodera
BACKGROUND: Gastric cancer (GC) relapse can occur even if curative resection is achieved. Biomarkers predicting recurrence are needed to provide appropriate postoperative surveillance and perioperative therapeutic strategy. METHODS: A global expression profiling was performed using tissues from GC patients with synchronous liver-confined metastasis. Family with sequence similarity 46, member C (FAM46C), was identified as a candidate biomarker. mRNA expression analysis, direct nucleotide sequencing, bisulfite sequencing and copy number assays for FAM46C were performed with eleven GC cell lines...
October 21, 2016: Annals of Surgical Oncology
Nurdan Tözün, Eser Vardareli
Gastrointestinal (GI) cancers are the leading cause of mortality worldwide. These cancers are the end result of a complex interplay between gene and environment. Bacteria, parasites, and viruses have been implicated in some cancers. Recent data have put at focus the gut microbiome as the key player firing tumorigenesis. Experimental and human studies have provided evidence on the role of microbiota in cancer development. Although subject to changes in different settings such as antibiotic treatment, diet or lifestyle, our microbiome is quite stable and is capable of increasing susceptibility to cancer or decrease and halt its progression...
November 2016: Journal of Clinical Gastroenterology
Hang Lu, Xue-Feng Yang, Xiao-Qing Tian, Shou-Long Tang, Lian-Qian Li, Shuang Zhao, Hua-Chuan Zheng
Here, we found that both SAHA and MG132 synergistically inhibited proliferation, glycolysis and mitochondrial oxidization, induced cell cycle arrest and apoptosis in MGC-803 and MKN28 cells. SAHA increased cell migration and invasionat a low concentration. SAHA induced the overexpression of acetyl histone 3 and 4, which were recruited to p21, p27, Cyclin D1, c-myc and nanog promoters to transcriptionally up-regulate the former two and down-regulate the latter three. The expression of acetyl-histone 3 and 4 was increased during gastric carcinogenesis and positively correlated with cancer differentiation...
August 30, 2016: Oncotarget
Takafumi Sato, Akio Saiura, Yosuke Inoue, Yu Takahashi, Junichi Arita, Nobuyuki Takemura
BACKGROUND: A distal pancreatectomy with en bloc celiac axis resection (DP-CAR) is indicated for left-sided locally advanced pancreatic ductal adenocarcinoma. However, ischemic complication resulting from the sacrifice of the common hepatic artery and left gastric artery (LGA) remain problematic. The aim of this study was to analyze the feasibility of DP-CAR with preservation or reconstruction of the left gastric artery. METHOD: Between April 2011 and December 2014, we treated 17 cases using DP-CAR with preservation or reconstruction of the LGA...
September 2016: World Journal of Surgery
L J Wang, Y M Zhang, Y L Deng, H Zheng, C Pan, Z Y Shen
OBJECTIVE: To evaluate the feasibility and outcome of liver transplantation in the treatment of liver metastatic cancer. METHODS: Four patients with pathologically confirmed liver metastatic cancer underwent liver transplantation, including one of liver metastases from pancreatic endocrine tumor, one from rectal endocrine tumor, one from stomach stromal tumor and one from colorectal carcinoma. Classic surgical method was adopted, i. e. orthotopic liver transplantation for the recipients and transplants came from cadaveric donors...
May 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
G A M Tiberio, S Ministrini, A Gardini, D Marrelli, A Marchet, C Cipollari, L Graziosi, C Pedrazzani, G L Baiocchi, G La Barba, F Roviello, A Donini, G de Manzoni
PURPOSE: To investigate clinical factors influencing the prognosis of patients submitted to hepatectomy for metastases from gastric cancer and their clinical role. METHODS: Retrospective multi-center chart review. We evaluated how survival from surgery was influenced by patient-related, gastric cancer-related, metastasis-related and treatment-related candidate prognostic factors. RESULTS: One hundred and five patients submitted to hepatectomy for metastases from gastric cancer, in the synchronous and metachronous setting of the disease...
August 2016: European Journal of Surgical Oncology
Reem Waziry, Mohammed Jawad, Rami A Ballout, Mohammad Al Akel, Elie A Akl
BACKGROUND AND AIMS: A systematic review conducted in 2008 found significant associations between waterpipe tobacco smoking and lung cancer, respiratory disease, periodontal disease and low birthweight. Since then, a number of relevant studies have been published. The objective of this study was to update the systematic review on the effects of waterpipe tobacco smoking on health outcomes. METHODS: In May 2015 we electronically searched the following databases with no date restrictions: MEDLINE, EMBASE and the ISI Web of Science using a detailed search strategy with no language restrictions...
April 13, 2016: International Journal of Epidemiology
V K Kapoor
UNLABELLED: Pancreato-duodenectomy (PD) is the procedure of choice for management of resectable periampullary and pancreatic cancers and some patients with chronic pancreatitis. PD is one of the most major GI/ HPB surgical procedures performed involving resection of multiple organs and reconstruction with multiple anastomoses. While mortality of PD has been brought down to less than 5% morbidity still remains high.Patients undergoing PD are usually elderly with comorbidities - general complications of a major operation e...
February 2016: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Y Teng, Y C Fan, N N Mu, J Zhao, F K Sun, K Wang
Promoter methylation of tumor suppressor gene SOX11 has been reported to contribute to the diagnosis and prognosis of various cancerous diseases, including gastric cancer, hematopoietic malignancies and nasopharyngeal carcinoma. However, there is no data on the diagnostic potential of serum SOX11 promoter methylation in hepatocellular carcinoma (HCC). This study was therefore aimed to investigate the potential role of serum SOX11 promoter methylation as a noninvasive biomarker in the diagnosis of patients with hepatitis B virus (HBV) associated HCC...
2016: Neoplasma
Weiwei Jin, Xiaowu Xu, Yiping Mou, Renchao Zhang, Chao Lu, Miaozun Zhang, Yucheng Zhou, Jingrui Wang
OBJECTIVE: To evaluate the feasibility and safety of laparoscopic pancreaticoduodenectomy(LPD). METHODS: Data of 66 patients from Sir Run Run Shaw Hospital undergoing LPD from September 2012 to September 2014 were reviewed. There were 44 male and 22 female with the mean age of (58.7±10.3) years and mean body mass index of (23.5±3.9)kg/m(2). Forty-five patients presented the symptoms and four of all had the history of abdominal surgery, including 2 cases of laparoscopic pancreatic surgery...
February 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
L Benhaim, C Honoré, D Goéré, J-B Delhorme, D Elias
BACKGROUND: Complete cytoreductive surgery (CCRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is the best-known treatment for pseudomyxoma peritonei (PMP). In 30% of the cases, PMP realize a widespread involvement of the peritoneal cavity. In these extreme situations, we developed, devoted strategies to optimize the feasibility and safety of CCRS. This study describes the surgical resections required for CCRS and the consequent approaches that we propose to achieve CCRS. MATERIALS AND METHODS: We defined "huge PMP" by a peritoneal cancer index (PCI) ≥ 28...
April 2016: European Journal of Surgical Oncology
H Ptok, I Gastinger, S Wolff, C Bruns, H Lippert
BACKGROUND: The benefits of primary tumor resection in metastatic disease remains a matter of debate. Existing data are almost exclusively limited to results from retrospective analyses. Data from prospective, randomized trials are currently not available. AIM: The results from two prospective observational studies involving gastric and rectal cancer patients are presented and discussed in the context of the available literature. METHOD: Based on data collected within the prospective quality assurance studies on gastric and rectal cancer conducted by the Institute for Quality Assurance in Surgery at Otto von Guericke University, Magdeburg, Germany, the long-term outcome after palliative primary tumor resection in patients with International Union Against Cancer (UICC) stage IV rectal cancer (2005-2008, n = 2046) and metastatic gastric cancer (2007-2009, n = 687) was analyzed and compared to published data...
March 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Yuichiro Sato, Takanori Kubo, Kinjiro Morimoto, Kazuyoshi Yanagihara, Toshio Seyama
BACKGROUND: Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidated. METHODS: Cell adherence potency of MKN28 upon PFL treatment was assessed using a colorimetric assay. Cell surface molecules to which PFL bound were identified by peptide mass finger printing with Matrix Assisted Laser Desorption/Ionization-time of flight mass spectrometry and their cellular localization determined by immunofluorescence microscopy...
2015: BMC Cancer
Takahiko Tanigawa, Yasunori Hasuike, Yousuke Akiyama, Ichiro Higuchi, Akira Ishikawa, Atsuya Okada, Makoto Miyamoto
The patient was an 83-year-old man who underwent distal gastrectomy for gastric cancer (T3, N1, M0, P0, M0, stage ⅡB) at a different hospital from ours. A metastatic lesion was detected in the liver 5 months after gastrectomy. Although chemotherapy with S-1 or bi-weekly CPT-11 was administered for 6 months, the liver tumor increased in size. The patient was referred to our hospital for treatment of the liver metastasis. Abdominal-computed tomography (CT) and magnetic resonance imaging (MRI) revealed a solitary metastatic liver tumor (9 cm in diameter: S7/S6/S8) with a hypervascular tumor stain...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Z Yang, Y Lu, Q Xu, X Chen
OBJECTIVE: This study aimed to evaluate the effect of age on the treatment comprising peginterferon plus ribavirin administered to patients with chronic hepatitis C (CHC). MATERIALS AND METHODS: A total of 314 patients with CHC treated with peginterferon plus ribavirin were classified into three categories according to age. The efficacy and safety outcomes were compared between groups. RESULTS: Elderly patients yielded significantly lower rapid virological response and sustained virological response (SVR) (31...
January 2016: Nigerian Journal of Clinical Practice
Xiao Zheng, Zhihui Liu, Shuang Li, Liling Wang, Jiajia Lv, Junsheng Li, Xingmiao Ma, Ling Fan, Fang Qian
A low molecular weight polysaccharide was identified from the flower of Abelmoschus manihot (Linn.) Medicus, a popular herbal medicine also known as Flos A. manihot. The polysaccharide, AMPS-a, was obtained from the ethanol-extracted debris of Flos A. manihot by successive purification through DEAE-cellulose-52 and Sephadex G-100 column. AMPS-a has an estimated molecular weight of 8.8×10(3)Da and is mainly composed of β-d-glucose, α-d-mannose, α-d-galactose and α-l-fucose at a molar ratio of 1.00:0.91:2...
January 2016: International Journal of Biological Macromolecules
T-L Kuo, C-C Weng, K-K Kuo, C-Y Chen, D-C Wu, W-C Hung, K-H Cheng
Adenomatous polyposis coli (APC), a tumor-suppressor gene critically involved in familial adenomatous polyposis, is integral in Wnt/β-catenin signaling and is implicated in the development of sporadic tumors of the distal gastrointestinal tract including pancreatic cancer (PC). Here we report for the first time that functional APC is required for the growth and maintenance of pancreatic islets and maturation. Subsequently, a non-Kras mutation-induced premalignancy mouse model was developed; in this model, APC haploinsufficiency coupled with p53 deletion resulted in the development of a distinct type of pancreatic premalignant precursors, mucinous cystic neoplasms (MCNs), exhibiting pathomechanisms identical to those observed in human MCNs, including accumulation of cystic fluid secreted by neoplastic and ovarian-like stromal cells, with 100% penetrance and the presence of hepatic and gastric metastases in >30% of the mice...
April 28, 2016: Oncogene
Hiroshi Seki, Hiroyuki Ohi, Toshirou Ozaki, Hiroshi Yabusaki
BACKGROUND: For patients with liver metastases from gastric cancer (LMGC), combination chemotherapy with fluoropyrimidines and platinum agents has been recognized as standard treatment. However, the prognosis of hepatic progression after first-line treatment failure remains poor. When hepatic progression occurs, hepatic arterial infusion (HAI) chemotherapy may be helpful for preventing disease progression. PURPOSE: To retrospectively assess the feasibility and efficacy of HAI chemotherapy using 5-fluorouracil, epirubicin, and mitomycin C (FEM) for patients with LMGC after failure of systemic S-1 plus cisplatin...
July 2016: Acta Radiologica
Joseph F Quinn, Tushar Patel, David Wong, Saumya Das, Jane E Freedman, Louise C Laurent, Bob S Carter, Fred Hochberg, Kendall Van Keuren-Jensen, Matt Huentelman, Robert Spetzler, M Yashar S Kalani, Jorge Arango, P David Adelson, Howard L Weiner, Roopali Gandhi, Beatrice Goilav, Chaim Putterman, Julie A Saugstad
Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders...
2015: Journal of Extracellular Vesicles
F Wang, M X Hou, X L Wu, L D Bao, P D Dong
We studied the effects of enteral nutrition (EN) support initiated 1 week before surgery on postoperative nutritional status, immune function, and inflammatory response in gastric cancer patients. A total of 200 gastric cancer patients were randomly divided into two groups: EN starting 1 week before surgery (study group) and EN starting early after surgery (control group). The two groups received EN support, following different therapeutic schedules, until the 9th day after operation. In the patients, body weight, skinfold thickness, upper-arm circumference, white blood cell count, albumin, prealbumin, C-reactive protein, peripheral immunoglobulins (IgA, IgG, and IgM), T lymphocyte subsets, interleukin-6, and tumor necrosis factor-α were measured 10 days before and after surgery and on the first day after surgery...
2015: Genetics and Molecular Research: GMR
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