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multiple sclerosis and quality of life

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https://www.readbyqxmd.com/read/28713238/targeting-cognitive-impairment-in-multiple-sclerosis-the-road-toward-an-imaging-based-biomarker
#1
Jeroen Van Schependom, Guy Nagels
Multiple Sclerosis (MS) is a neuro-degenerative and -inflammatory disease leading to physical and cognitive impairment, pathological fatigue and depression, and affecting patients' quality of life and employment status. The combination of inflammation, demyelination, and neurodegeneration leads to the emergence of MS lesions, reduced white and gray matter brain volumes, a reduced conduction velocity and microstructural changes in the so-called Normal Appearing White Matter (NAWM). Currently, there are very limited options to treat cognitive impairment and its origin is only poorly understood...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28703365/phototherapy-in-systemic-sclerosis-review
#2
REVIEW
Suteeraporn Chaowattanapanit, Charoen Choonhakarn, Chingching Foocharoen, Narachai Julanon
Systemic scleroderma-also known as systemic sclerosis (SSc)-is a chronic systemic connective tissue disease characterized by collagen deposition in cutaneous and internal organs, leading to skin sclerosis and multiple organ fibrosis. The pathogenesis is complex and remains poorly understood. Treatment is based on organ involvement and requires a multidisciplinary approach. Skin sclerosis can cause disability, leading to decreasing quality of life. Various systemic anti-fibrotic therapies have been used; however, most have unsatisfactory results...
July 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28697504/effects-of-a-training-program-involving-body-cooling-on-physical-and-cognitive-capacities-and-quality-of-life-in-multiple-sclerosis-patients-a-pilot-study
#3
Benoit Gonzales, Gilles Chopard, Benjamin Charry, Eric Berger, Julien Tripard, Eloi Magnin, Alain Groslambert
OBJECTIVE: Two methods using exercise and body cooling could influence the well-being of patients with multiple sclerosis (PwMS). The aim of this study was to determine whether wearing a cooling vest during a physical training program could increase the cognitive and physical capacities and quality of life in PwMS. METHODS: Eighteen PwMS (49.6 ± 8 years; Expanded Disability Status Score 5.0 ± 1.0) were randomly assigned to a cooling or control group. PwMS underwent a 7-week physical training program...
July 12, 2017: European Neurology
https://www.readbyqxmd.com/read/28696991/the-practice-of-sport-in-multiple-sclerosis-update
#4
Cecile Donze, Caroline Massot, Patrick Hautecoeur, Helene Cattoir-Vue, Marc-Alexandre Guyot
The practice of sport by multiple sclerosis patients has long been controversial. Recent studies, however, show that both sport and physical activity are essential for these patients. Indeed, they help to cope with the effects of multiple sclerosis, such as fatigue, reduced endurance, loss of muscle mass, and reduction of muscle strength. The beneficial effects of physical activity on these patients have been underlined in several studies, whereas those of practicing sport have been the subject of fewer evaluations and assessments...
July 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28695634/patient-reported-outcomes-in-multiple-sclerosis-a-systematic-comparison-of-available-measures
#5
REVIEW
V Khurana, H Sharma, N Afroz, A Callan, J Medin
Multiple patient-reported outcomes (PROs) are currently being used in multiple sclerosis (MS) but their application is inconsistent and guidance on the appropriateness of each tool is lacking. The objective of our study was to identify MS-specific PROs and systematically to assess the development process and the reliability and validity of various instruments. A systematic literature search was conducted on multiple data sources, including MEDLINE, Embase (using the Ovid platform) and Google Scholar, from 1996 to March 2015...
July 11, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28692670/patient-reported-outcomes-and-survival-in-multiple-sclerosis-a-10-year-retrospective-cohort-study-using-the-multiple-sclerosis-impact-scale-29
#6
Joel Raffel, Alison Wallace, Djordje Gveric, Richard Reynolds, Tim Friede, Richard Nicholas
BACKGROUND: There is increasing emphasis on using patient-reported outcomes (PROs) to complement traditional clinical outcomes in medical research, including in multiple sclerosis (MS). Research, particularly in oncology and heart failure, has shown that PROs can be prognostic of hard clinical endpoints such as survival time (time from study entry until death). However, unlike in oncology or cardiology, it is unknown whether PROs are associated with survival time in neurological diseases...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28691532/is-the-effect-of-coping-styles-disease-specific-relationships-with-emotional-distress-and-quality-of-life-in-acquired-brain-injury-and-multiple-sclerosis
#7
Ingrid Brands, Yvonne Bol, Sven Stapert, Sebastian Köhler, Caroline van Heugten
OBJECTIVE: To investigate the use of coping styles and the relationships linking coping to emotional distress and quality of life in patients with acquired brain injury and multiple sclerosis. METHOD: Cross-sectional cohort study of 143 patients with acquired brain injury and 310 patients with multiple sclerosis in the chronic stage. Quality of life was measured with the Life Satisfaction Questionnaire (LiSat-9), coping styles with the Coping Inventory for Stressful Situations (CISS-T, task-oriented; CISS-E, emotion-oriented; CISS-A, avoidance), emotional distress with the Hospital Anxiety and Depression Scale (HADS)...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28689102/monthly-methylprednisolone-in-combination-with-interferon-beta-or-glatiramer-acetate-for-relapsing-remitting-multiple-sclerosis-a-multicentre-single-blind-prospective-trial
#8
Serkan Ozakbas, Bilge Piri Cinar, Gorkem Kosehasanoğullari, Turhan Kahraman, Didem Oz, Behice Bircan Kursun
OBJECTIVES: Multiple sclerosis is usually clinically characterized by repeated subacute relapses followed by remissions. Corticosteroids are used for relapses, and this treatment has been shown to increase the speed of recovery from these. We aimed to evaluate the efficacy and safety of pulsed methylprednisolone given every month as an add-on therapy to interferon beta or glatiramer acetate in patients with relapsing-remitting multiple sclerosis. PATIENTS AND METHODS: This was a multi-center, examiner-blinded, prospective study...
June 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28688015/erratum-to-health-related-quality-of-life-in-patients-with-multiple-sclerosis-impact-of-disease-modifying-drugs
#9
Peter Joseph Jongen
No abstract text is available yet for this article.
July 7, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28687973/effect-of-exercise-therapy-on-quality-of-life-of-patients-with-multiple-sclerosis-in-iran-a-systematic-review-and-meta-analysis
#10
REVIEW
Abolhassan Afkar, Asieh Ashouri, Marjan Rahmani, Abdolhosein Emami Sigaroudi
Multiple sclerosis (MS) is a chronic and progressive disease charachterized by disabilities which adversely affect individuals' quality of life (QOL). In the present study, the effect size of exercise therapy on patients' QOL in both physical and mental dimensions were investigated and the moderator effect of a number of selected theoretical and significant practical variables were assessed. Relevant studies, published before July 2015, were identified by searching PubMed, Scopus, Google scholar, and Persian medical databases including IranMedex, Irandoc, Magiran, Scientific Information Database (SID), and Medlib...
July 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28681596/high-intensity-interval-training-combined-with-resistance-training-improves-physiological-capacities-strength-and-quality-of-life-in-multiple-sclerosis-patients-a-pilot-study
#11
Pierre Zaenker, Fabrice Favret, Evelyne Lonsdorfer, Guillaume Muff, Jérôme DE Seze, Marie-Eve Isner-Horobeti
BACKGROUND: Numerous studies have shown that mild-to-moderate intensity or resistance exercise training improves physical capacities such as, peak oxygen consumption, maximal tolerated power and strength in multiple sclerosis patients. However, few studies have evaluated the effects of high intensity interval training associated to with resistance training. Only few studies have analysed difference between men and women before and after combined training. Moreover, the evaluation of exercise between ambulatory multiple sclerosis patients without disability (EDSS 0- 3) and patients with disabilities (EDSS 3...
July 5, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28680310/validity-and-reliability-of-the-turkish-version-of-the-monitoring-my-multiple-sclerosis-scale
#12
Cansu Polat, Zeliha Tülek, Murat Kürtüncü, Mefkure Eraksoy
INTRODUCTION: This research was conducted to adapt the Monitoring My Multiple Sclerosis (MMMS) scale, which is a scale used for self-evaluation by multiple sclerosis (MS) patients of their own health and quality of life, to Turkish and to determine the psychometric properties of the scale. METHODS: The methodological research was conducted in the outpatient MS clinic of a university hospital between January and September 2013. The sample in this study consisted of 140 patients aged above 18 who had a diagnosis of definite MS...
June 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28670113/long-term-natalizumab-treatment-is-associated-with-sustained-improvements-in-quality-of-life-in-patients-with-multiple-sclerosis
#13
John F Foley, Kavita V Nair, Timothy Vollmer, Judith J Stephenson, Timothy Niecko, Sonalee S Agarwal, Crystal Watson
BACKGROUND: Multiple sclerosis (MS) patients experience lower health-related quality of life (HRQoL) than the general population. In clinical trials, natalizumab significantly improved HRQoL and reduced relapse rates and disability progression in patients with relapsing MS. In a 1-year analysis of patients included in the current study, HRQoL improvement occurred within 3 months of natalizumab initiation and continued for 1 year thereafter. However, natalizumab's long-term efficacy in improving HRQoL has not been studied...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28660550/clinical-and-economic-evaluation-of-repository-corticotropin-injection-a-narrative-literature-review-of-treatment-efficacy-and-healthcare-resource-utilization-for-seven-key-indications
#14
REVIEW
Michael Philbin, John Niewoehner, George J Wan
INTRODUCTION: Repository corticotropin injection (RCI; H.P. Acthar(®) Gel; Mallinckrodt Pharmaceuticals Inc., Hampton, NJ) is a highly purified, prolonged-release porcine preparation of adrenocorticotropic hormone (ACTH) analogue that is FDA-approved for treatment of 19 autoimmune and inflammatory disorders. The diverse physiological actions of RCI at the melanocortin receptors (MCRs) affect processes involved in inflammation, pigmentation, steroidogenesis, and immunomodulation. Although RCI has been approved to treat inflammatory and autoimmune diseases for more than 60 years, recent progress in understanding both MCRs and the effects of RCI in modulating immune responses has led to increased interest in RCI as a therapeutic choice...
June 28, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28655166/communication-in-multiple-sclerosis-pragmatic-deficit-and-its-relation-with-cognition-and-social-cognition
#15
Antonio Carotenuto, Giorgio Arcara, Giuseppe Orefice, Ilaria Cerillo, Valentina Giannino, Mario Rasulo, Rosa Iodice, Valentina Bambini
Objective: Cognitive functions have been largely investigated in multiple sclerosis. Less attention has been paid to social communication abilities, despite their presumptive affect on quality of life. We run the first comprehensive assessment of pragmatic skills in multiple sclerosis, evaluating also the relationship between pragmatics and other cognitive domains. Methods: Forty-two multiple sclerosis patients and 42 controls were tested for pragmatic abilities, neuro-cognition, social cognition, depression, and fatigue...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28643601/new-insights-into-the-burden-and-costs-of-multiple-sclerosis-in-europe-results-for-sweden
#16
Lou Brundin, Gisela Kobelt, Jenny Berg, Daniela Capsa, Jennifer Eriksson
BACKGROUND: To assess the value of management strategies in multiple sclerosis (MS), outcome data have to be combined with cost data. This requires that cost data be regularly updated. OBJECTIVE AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting current data on resource consumption, work capacity and health-related quality of life (HRQoL). Descriptive analyses are presented by level of severity; costs are estimated in the societal perspective, in 2015 SEK...
August 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28643600/new-insights-into-the-burden-and-costs-of-multiple-sclerosis-in-europe-results-for-italy
#17
Mario Battaglia, Gisela Kobelt, Michela Ponzio, Jenny Berg, Daniela Capsa, Johan Dalén
INTRODUCTION: In order to estimate the value of interventions in multiple sclerosis (MS) - where lifetime costs and outcomes cannot be observed - outcome data have to be combined with costs. This requires that cost data be regularly updated. OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS...
August 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28643599/new-insights-into-the-burden-and-costs-of-multiple-sclerosis-in-europe-results-for-austria
#18
Thomas Berger, Gisela Kobelt, Jenny Berg, Daniela Capsa, Mia Gannedahl
INTRODUCTION: In order to estimate the value of interventions in multiple sclerosis (MS) - where lifetime costs and outcomes cannot be observed - outcome data have to be combined with costs. This requires that cost data be regularly updated. OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS...
August 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28643598/new-insights-into-the-burden-and-costs-of-multiple-sclerosis-in-europe-results-for-belgium
#19
Benedicte Dubois, Gisela Kobelt, Jenny Berg, Daniela Capsa, Mia Gannedahl
INTRODUCTION: In order to estimate the value of interventions in multiple sclerosis (MS) - where lifetime costs and outcomes cannot be observed - outcome data have to be combined with costs. This requires that cost data be regularly updated. OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS...
August 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28643597/new-insights-into-the-burden-and-costs-of-multiple-sclerosis-in-europe-results-for-spain
#20
Celia Oreja-Guevara, Gisela Kobelt, Jenny Berg, Daniela Capsa, Jennifer Eriksson
INTRODUCTION: In order to estimate the value of interventions in multiple sclerosis (MS) where lifetime costs and outcomes cannot be observed, outcome data have to be combined with costs. This requires that cost data be regularly updated. OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption, work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS...
August 2017: Multiple Sclerosis: Clinical and Laboratory Research
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