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multiple sclerosis and quality of life

James H Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine, Tapan Mehta
BACKGROUND: Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues. METHODS: Our Russian doll framework encompasses three study phases. Phase 1 involves prospectively following a cohort of participants with disability to examine the relationships between rates of health and functional deficits (e.g., pain, fatigue, deconditioning), functional measures (e...
March 14, 2018: BMC Medical Research Methodology
Carolina Candeias da Silva, Denis Bernardi Bichuetti, Sonia Maria Cesar de Azevedo Silva, Henrique Ballalai Ferraz, Enedina Maria Lobato de Oliveira, Vanderci Borges
INTRODUCTION: Movement disorders are not rare in demyelinating diseases but there are few studies comparing their frequency between multiple sclerosis and neuromyelitis optica spectrum disorder. Our aim was to determine the frequency and the related features of movement disorders in a cohort of patients with multiple sclerosis and neuromyelitis optica spectrum disorder. METHODS: It is a cross-sectional study of patients with multiple sclerosis and neuromyelitis optica spectrum disorder...
March 3, 2018: Parkinsonism & related Disorders
Mariko Kita, Robert J Fox, Ralf Gold, Gavin Giovannoni, J Theodore Phillips, Sujata P Sarda, Jessica Kong, Vissia Viglietta, Sarah I Sheikh, Macaulay Okwuokenye, Ludwig Kappos
No abstract text is available yet for this article.
March 7, 2018: Clinical Therapeutics
Neil H Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E Fearnot, Michael E Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N Patel, Santosh Kesari, Jorge Paz Rodriguez
BACKGROUND: Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used in the last decade to safely treat certain immune and inflammatory conditions. METHODS: A safety and feasibility study was completed on the use of umbilical cord MSC (UCMSC) as a treatment for MS. In this 1-year study, consenting subjects received seven intravenous infusions of 20 × 106 UCMSC over 7 days...
March 9, 2018: Journal of Translational Medicine
Amy-Lee Sesel, Louise Sharpe, Sharon L Naismith
BACKGROUND: Psychosocial interventions are often used as an adjunct to the medical management of multiple sclerosis (MS). However, the efficacy of such approaches for a range of psychosocial indications remains unclear. OBJECTIVE: To determine the efficacy of psychosocial therapies for people with MS (PwMS). METHODS: We searched 6 electronic databases (Medline, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, and Clinicaltrials...
March 8, 2018: Psychotherapy and Psychosomatics
Jodie Stephenson, Erik Nutma, Paul van der Valk, Sandra Amor
Neurodegenerative diseases, the leading cause of morbidity and disability is gaining increased attention as it imposes a considerable socioeconomic impact, due in part to the ageing community. Neuronal damage is a pathological hallmark of Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, spinocerebellar ataxia and multiple sclerosis, although such damage is also observed following neurotropic viral infections, stroke, genetic white matter diseases and paraneoplastic disorders...
March 7, 2018: Immunology
Kimia Seifi, Hossein Ebrahimi Moghaddam
This study aimed to investigate the effectiveness of self-care plan on the life quality of patients with Multiple sclerosis (MS). The samples in this study included all the patients with MS under medical coverage of Iranian Association of supporting patients with MS in Tehran in 2015 who were studied as Convenience sampling and based on the inclusion and exclusion criteria. In this study, Dr. Madani's self-care program as an intervention and The World Health Organization Quality of Life (WHOQOL)-BREF for assessment of consequences were used...
February 2018: Journal of the National Medical Association
Barbara Seebacher, Raija Kuisma, Angela Glynn, Thomas Berger
Background: Motor imagery (MI) is increasingly used in neurorehabilitation to facilitate motor performance. Our previous study results demonstrated significantly improved walking after rhythmic-cued MI in people with multiple sclerosis (pwMS). The present feasibility study was aimed to obtain preliminary information of changes in walking, fatigue, quality of life (QoL) and MI ability following cued and non-cued MI in pwMS. The study further investigated the feasibility of a larger study and examined the reliability of a two-dimensional gait analysis system...
2018: Archives of Physiotherapy
Kenneth I Pakenham, Theresa Scott, Michele Messmer Uccelli
Background: Acceptance and commitment therapy (ACT) is the most widely used and researched recent variant of cognitive behavioral therapy and has been shown to increase quality of life in people with chronic illnesses, including multiple sclerosis (MS). However, few MS health practitioners are trained in ACT. This study evaluated a 2-day ACT training workshop for Italian psychologists working with people with MS. Methods: Data were collected via online questionnaires from 34 psychologists before the workshop, after the workshop, and at 6-month follow-up...
January 2018: International Journal of MS Care
Neepa Patel, Hannah Combs, Michele York, Cecile Phan, Joohi Jimenez-Shahed
Pseudobulbar affect (PBA) is a syndrome of affective disturbance associated with inappropriate laughter and crying, independent of mood. PBA is common in amyotrophic lateral sclerosis (ALS) and increasingly recognized in Parkinson's disease (PD) and atypical parkinsonism (aP). Correlates of PBA have not been systematically studied. The purpose of this study was to determine whether cognitive and psychiatric comorbidities correlated with patient-reported symptoms of PBA by using the Center for Neurological Study-Lability Scale among patients with ALS, PD, and aP...
March 5, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
Guido Giunti, Vasiliki Mylonopoulou, Octavio Rivera Romero
BACKGROUND: Multiple sclerosis (MS) is one of the world's most common neurologic disorders. Fatigue is one of most common symptoms that persons with MS experience, having significant impact on their quality of life and limiting their activity levels. Self-management strategies are used to support them in the care of their health. Mobile health (mHealth) solutions are a way to offer persons with chronic conditions tools to successfully manage their symptoms and problems. Gamification is a current trend among mHealth apps used to create engaging user experiences and is suggested to be effective for behavioral change...
March 2, 2018: JMIR MHealth and UHealth
Laura Dennison, Martina Brown, Sarah Kirby, Ian Galea
BACKGROUND: Multiple sclerosis (MS) has a varied and uncertain trajectory. The recent development of analytical processing tools that draw on large longitudinal patient databases facilitates personalised long-term prognosis estimates. This has the potential to improve both shared treatment decision-making and psychological adjustment. However, there is limited research on how people with MS feel about prognosis communication and forecasting. This study investigated the prognosis communication experiences and preferences of people with MS and explored whether clinical, demographic and psychological factors are associated with prognosis information preferences...
2018: PloS One
Jana Pöttgen, Anita Rose, Wim van de Vis, Jannie Engelbrecht, Michelle Pirard, Stefanie Lau, Christoph Heesen, Sascha Köpke
OBJECTIVE: Sexual dysfunction in multiple sclerosis (MS) is a significant, but often underestimated and overlooked suffering. Interventions to treat sexual dysfunction in MS are rare. The relation between sexual dysfunction in MS and psychological as well as neuropsychological aspects is evident. However, this field of research remains markedly underdeveloped in this severe chronic illness. The aim of this scoping review is to describe the relevant knowledge in this area and to identify psychological interventions to treat sexual dysfunctions in MS...
2018: PloS One
Cesare Cavalera, Marco Rovaris, Laura Mendozzi, Luigi Pugnetti, Massimo Garegnani, Gianluca Castelnuovo, Enrico Molinari, Francesco Pagnini
BACKGROUND: Multiple sclerosis (MS) has a relevant impact on quality of life (QOL) and is associated with increased risks of psychological morbidity. Mindfulness-based interventions (MBIs) are among the most studied interventions, although few well-conducted studies have tested them in this field. Furthermore, the participation in typical MBIs may be impaired by time and logistics. OBJECTIVE: We aimed to test the efficacy of an online MBI to improve QOL, psychological well-being, sleep, and fatigue...
February 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Helene Højsgaard Chow, Karen Schreiber, Melinda Magyari, Cecilie Ammitzbøll, Lars Börnsen, Jeppe Romme Christensen, Rikke Ratzer, Per Soelberg Sørensen, Finn Sellebjerg
Background: Patients with progressive multiple sclerosis (MS) often have cognitive impairment in addition to physical impairment. The burden of cognitive and physical impairment progresses over time, and may be major determinants of quality of life. The aim of this study was to assess to which degree quality of life correlates with physical and cognitive function in progressive MS. Methods: This is a retrospective study of 52 patients with primary progressive ( N  = 18) and secondary progressive MS ( N  = 34)...
February 2018: Brain and Behavior
Melissa Colbeck
BACKGROUND: Quality of life for persons living with multiple sclerosis (MS) is significantly lower than population norms. Fatigue, both physical and cognitive, is one of the most prevalent and debilitating symptoms of MS that decrease quality of life. Cognitive fatigue presents similarly to sensory overresponsiveness, but the connection has not been explored. PURPOSE: This study aims to describe how sensory-processing preferences and cognitive fatigue relate to variances in quality of life for people with MS...
January 1, 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
Flora M Hammond, William Sauve, Fred Ledon, Charles Davis, Andrea E Formella
BACKGROUND: Dextromethorphan 20mg /quinidine 10mg (DM/Q) was approved to treat pseudobulbar affect (PBA) based upon phase 3 trials conducted in participants with amyotrophic lateral sclerosis or multiple sclerosis. PRISM II evaluated DM/Q effectiveness, safety and tolerability for PBA following stroke, dementia or traumatic brain injury (TBI). OBJECTIVE: To report results from the TBI cohort of PRISM II, including a TBI-specific functional scale. DESIGN: Open-label trial evaluating twice daily DM/Q over 90 days...
February 22, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Alexa K Stuifbergen, Heather Becker, Francisco Perez, Janet Morrison, Adama Brown, Vicki Kullberg, Wenhui Zhang
BACKGROUND: The effects of multiple sclerosis (MS) on cognition have gained increasing recognition as one of the major disabling symptoms of the disease. Despite the prevalence of these symptoms and their impact on quality of life, limited attention has been given to strategies that might help manage the cognitive changes commonly experienced by persons with MS. OBJECTIVE: The primary purpose of this study was to determine the effectiveness of a novel computer-assisted cognitive rehabilitation intervention MAPSS-MS (Memory, Attention, Problem Solving Skills in MS) in a multi-site trial with persons with MS...
February 16, 2018: Disability and Health Journal
Adebimpe O Obembe, Charlie H Goldsmith, Lisa A Simpson, Brodie M Sakakibara, Janice J Eng
BACKGROUND: Social support can help to deal with the consequences of neurological conditions and promote functional independence and quality of life. Our aim was to evaluate the impact of neurological conditions on the use of support and health-care services in a population-based sample of community-dwelling adults with neurological conditions. METHODS: Data were from the Survey of Living with Neurological Conditions in Canada, which was derived from a representative sample of household residents...
2018: PloS One
U Palm, M A Chalah, A Créange, J-P Lefaucheur, S S Ayache
Fatigue and depression are frequent symptoms in multiple sclerosis (MS). Both are overlapping and shadowing each other and may impair the quality of life. For detection of depression symptoms in MS, the Multiple Sclerosis Depression Rating Scale (MSDRS) has been proposed recently. Here, we compare the performance of MSDRS in MS patients with and without fatigue to that of established rating scales, i.e. Hospital Anxiety and Depression Scale and Beck Depression Inventory. Twenty-nine MS patients were screened for fatigue and depression symptoms...
February 17, 2018: L'Encéphale
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