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multiple sclerosis and quality of life

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https://www.readbyqxmd.com/read/28915856/exercise-prescription-for-patients-with-multiple-sclerosis-potential-benefits-and-practical-recommendations
#1
Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian, Maryam Abolhasani
BACKGROUND: Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression. Patients with MS frequently decrease physical activity due to the fear from worsening the symptoms and this can result in reconditioning. Physicians now believe that regular exercise training is a potential solution for limiting the reconditioning process and achieving an optimal level of patient activities, functions and many physical and mental symptoms without any concern about triggering the onset or exacerbation of disease symptoms or relapse...
September 16, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28914229/clinical-effectiveness-and-cost-effectiveness-of-beta-interferon-and-glatiramer-acetate-for-treating-multiple-sclerosis-systematic-review-and-economic-evaluation
#2
G J Melendez-Torres, Peter Auguste, Xavier Armoiry, Hendramoorthy Maheswaran, Rachel Court, Jason Madan, Alan Kan, Stephanie Lin, Carl Counsell, Jacoby Patterson, Jeremy Rodrigues, Olga Ciccarelli, Hannah Fraser, Aileen Clarke
BACKGROUND: At the time of publication of the most recent National Institute for Health and Care Excellence (NICE) guidance [technology appraisal (TA) 32] in 2002 on beta-interferon (IFN-β) and glatiramer acetate (GA) for multiple sclerosis, there was insufficient evidence of their clinical effectiveness and cost-effectiveness. OBJECTIVES: To undertake (1) systematic reviews of the clinical effectiveness and cost-effectiveness of IFN-β and GA in relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and clinically isolated syndrome (CIS) compared with best supportive care (BSC) and each other, investigating annualised relapse rate (ARR) and time to disability progression confirmed at 3 months and 6 months and (2) cost-effectiveness assessments of disease-modifying therapies (DMTs) for CIS and RRMS compared with BSC and each other...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28913785/evolution-of-patient-reported-outcomes-and-their-role-in-multiple-sclerosis-clinical-trials
#3
REVIEW
Cindy J Nowinski, Deborah M Miller, David Cella
Patient-reported outcomes (PROs) are playing an increasing role in multiple sclerosis (MS) research and practice, and are essential for understanding the effects that MS and MS treatments have on patients' lives. PROs are captured directly from patients and include symptoms, function, health status, and health-related quality of life. In this article, we review different categories (e.g., generic, targeted, preference-based) of PRO measures and considerations in selecting a measure. The PROs included in MS clinical research have evolved over time, as have the measures used to assess them...
September 14, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28904538/the-effect-of-group-cognitive-behavioral-therapy-on-stress-anxiety-and-depression-of-women-with-multiple-sclerosis
#4
Saeid Pahlavanzadeh, Samira Abbasi, Nasrollah Alimohammadi
BACKGROUND: One of the factors that could influence the quality of life in patients with multiple sclerosis, which is usually overlooked, is its psychological aspects. Considering the increasing acceptance of complementary medicine in the health system, this study was designed and conducted to determine the effect of group cognitive therapy on the stress, anxiety, and depression of women suffering from multiple sclerosis. MATERIALS AND METHODS: This clinical trial was conducted among 70 women suffering from multiple sclerosis who were referred to the health centers of Isfahan...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28900546/short-term-and-long-term-effects-of-an-exercise-based-patient-education-programme-in-people-with-multiple-sclerosis-a-pilot-study
#5
Christina Lutz, Stephanie Kersten, Christian T Haas
Background. Although people with Multiple Sclerosis (pwMS) benefit from physical exercise, they still show reduced physical activity and exercise behaviour. This study aimed to investigate short- and long-term effects of an exercise-based patient education programme (ePEP) that focuses on empowering pwMS to a sustainable and self-regulated exercise training management. Methods. Fourteen pwMS were randomly assigned to immediate experimental group (EG-I: n = 8) and waitlist-control group (EG-W: n = 6) and attended biweekly in a six-week ePEP...
2017: Multiple Sclerosis International
https://www.readbyqxmd.com/read/28895427/the-impact-of-self-perceived-limitations-stigma-and-sense-of-coherence-on-quality-of-life-in-multiple-sclerosis-patients-results-of-a-cross-sectional-study
#6
Feddrik Broersma, Barth Oeseburg, Jacob Dijkstra, Klaske Wynia
OBJECTIVE: To examine the impact of perceived limitations, stigma and sense of coherence on quality of life in multiple sclerosis patients. DESIGN: Cross-sectional survey. SETTING: Department of Neurology, University Medical Center Groningen, the Netherlands. SUBJECTS: Multiple sclerosis patients. MAIN MEASURES: World Health Organization Quality of Life - abbreviated version, Stigma Scale for Chronic Illness, Sense of Coherence Scale, background and disease-related questions...
September 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28888468/effect-of-visual-biofeedback-cycling-training-on-gait-in-patients-with-multiple-sclerosis
#7
A Hochsprung, A Granja Domínguez, E Magni, S Escudero Uribe, A Moreno García
INTRODUCTION: Gait alterations are present in a high percentage of patients with multiple sclerosis (MS). They appear from early stages of the disease and can limit patients' capacity to perform basic activities of daily living, affecting their quality of life. Visual biofeedback cycling training appears to be a useful tool in treating these impairments. This study aims to evaluate the short-term effect of visual biofeedback cycling training on gait in patients with MS. MATERIAL AND METHODS: A total of 61 patients with mild to moderate MS were randomly assigned to a control group and an intervention group...
September 6, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28885451/visual-structure-and-function-in-collision-sport-athletes
#8
Danielle Leong, Christina Morettin, Leonard V Messner, Robert J Steinmetz, Yi Pang, Steven L Galetta, Laura J Balcer
BACKGROUND: Vision-based measures have been shown to be useful markers in multiple sclerosis (MS), Alzheimer and Parkinson disease. Therefore, these testing paradigms may have applications to populations explaining repetitive head trauma that has been associated with long-term neurodegenerative sequelae. We investigated retinal structure and visual function in professional collision sport athletes compared to age- and race-matched control participants. METHODS: In this cross-sectional study, participants underwent spectral-domain optical coherence tomography (OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC = ganglion cell + inner plexiform layers) thickness...
September 6, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28885372/light-therapy-for-multiple-sclerosis-associated-fatigue-study-protocol-for-a-randomized-controlled-trial
#9
Farrah J Mateen, Natalie C Manalo, Sara J Grundy, Melissa A Houghton, Gladia C Hotan, Hans Erickson, Aleksandar Videnovic
BACKGROUND: Fatigue is the most commonly reported symptom among multiple sclerosis (MS) patients, more than a quarter of whom consider fatigue to be their most disabling symptom. However, there are few effective treatment options for fatigue. We aim to investigate whether supplemental exposure to bright white light will reduce MS-associated fatigue. METHODS: Eligible participants will have clinically confirmed multiple sclerosis based on the revised McDonald criteria (2010) and a score ≥36 on the Fatigue Severity Scale (FSS)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28882362/independent-association-of-joint-space-narrowing-cyst-formation-and-health-related-quality-of-life-of-patients-with-hip-osteoarthritis-in-japan
#10
Yasuhiko Takegami, Taisuke Seki, Yoshitoshi Higuchi, Daigo Komatsu, Yoshihiro Nishida, Naoki Ishiguro
INTRODUCTION: This study clarified individual associations of joint space narrowing (JSN) and radiographic features (RF) of hip osteoarthritis (HOA), i.e., cyst and osteophyte formation and subchondral sclerosis, with quality of life (QOL) in Japanese HOA patients. METHODS: This cross-sectional study comprised 117 Japanese HOA patients (98 women, 17 men; mean age, 61.2 years). We recorded locations and the size of each RF and measured JSN on the acetabular side (Ace) or femoral head (FH)...
September 4, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28875857/is-there-a-link-between-vitamin-b-and-multiple-sclerosis
#11
Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L Blatch, Vasso Apostolopoulos
BACKGROUND: Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiency results in severe myelin degeneration that leads to loss in neuronal signal transmission. OBJECTIVE: Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has had increased attention for its role in the methylation process, involvement in myelination and re-myelination, and reversal of MS symptoms...
September 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28866778/systematic-review-of-the-costs-and-benefits-of-prescribed-cannabis-based-medicines-for-the-management-of-chronic-illness-lessons-from-multiple-sclerosis
#12
REVIEW
Samuel Herzog, Marian Shanahan, Peter Grimison, Anh Tran, Nicole Wong, Nicholas Lintzeris, John Simes, Martin Stockler, Rachael L Morton
INTRODUCTION: Cannabis-based medicines (CBMs) may offer relief from symptoms of disease; however, their additional cost needs to be considered alongside their effectiveness. We sought to review the economic costs and benefits of prescribed CBMs in any chronic illness, and the frameworks used for their economic evaluation. METHODS: A systematic review of eight medical and economic databases, from inception to mid-December 2016, was undertaken. MeSH headings and text words relating to economic costs and benefits, and CBMs were combined...
September 2, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28862920/social-cognitive-factors-physical-activity-and-mobility-impairment-in-adults-with-multiple-sclerosis
#13
Susan L Kasser, Maria Kosma
Among those with multiple sclerosis (MS), mobility impairment is common and significantly affects independent functioning and quality of life. The purpose of the study was to examine the role of physical activity in mobility impairment in individuals with MS and explore the social cognitive factors of social support, outcome expectations, and self-efficacy that facilitate physical activity among those with the disease. A sample of 319 individuals with MS were assessed on the following: family and friend social support, self-efficacy, and physical and social outcome expectations...
September 1, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28858096/fall-prevalence-in-people-with-multiple-sclerosis-who-use-wheelchairs-and-scooters
#14
Laura Rice, Alon Kalron, Shani H Berkowitz, Deborah Backus, Jacob J Sosnoff
Falls are a serious health concern for persons with multiple sclerosis (PwMS) who use wheelchairs or scooters as their primary mode of mobility. Unfortunately, little is known about the fall prevalence and characteristics of this large segment of the multiple sclerosis (MS) community. The purpose of this study is to determine the prevalence and circumstances of falls in wheelchair and scooter users living with MS. Forty-four PwMS were recruited from research and medical centers in the United States and Asia...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28852436/feasibility-and-toxicity-of-hematopoietic-stem-cell-transplant-in-multiple-sclerosis
#15
REVIEW
Thomas Low Tat Kuan, Farahnaz Amini, Marjan Sadat Seghayat
Multiple sclerosis is a debilitating disease of the central nervous system. It affects people of all ages but is more prevalent among 20-40 year olds. Patients with MS can be presented with potentially any neurological symptom depending on the location of the lesion. A quarter of patients with MS suffer from bilateral lower limb spasticity among other symptoms. These devastating effects can be detrimental to the patient's quality of life. Hematopoietic stem cells (HSCs) have been used as a treatment for MS over the past 2 decades but their safety and efficacy has are undetermined...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28835744/depression-and-age-at-first-neurology-appointment-associated-with-receipt-of-behavioral-medicine-services-within-1-year-in-a-multiple-sclerosis-population
#16
Benjamin Greenberg, Youran Fan, Lucille Carriere, Amy Sullivan
BACKGROUND: Patients with multiple sclerosis (MS) newly seen by a neurologist may benefit from early psychological intervention owing to the reciprocal relationship between stress and disease progression. However, it is uncertain what factors contribute to patients' receiving these services. METHODS: Logistic regression analysis of prospectively gathered data evaluated how demographic and disease characteristics and emotional/physical health factors contributed to referral to receive behavioral medicine (BM) services within 1 year of their first neurology appointment at the Mellen Center for Multiple Sclerosis at the Cleveland Clinic...
July 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28831635/a-multicenter-observational-prospective-study-of-self-and-parent-reported-quality-of-life-in-adolescent-multiple-sclerosis-patients-self-administering-interferon-%C3%AE-1a-using-rebismart%C3%A2-the-future-study
#17
A Ghezzi, A Bianchi, D Baroncini, A Bertolotto, S Malucchi, V Bresciamorra, R Lanzillo, N Milani, V Martinelli, F Patti, C Chisari, M Rottoli, M Simone, D Paolicelli, A Visconti
Besides the impact of disease per se, the use of immunomodulatory therapies in adolescents with relapsing-remitting multiple sclerosis (RRMS) may have an effect on quality of life (QL). The FUTURE (Quality of liFe in adolescent sUbjecTs affected by mUltiple sclerosis treated with immunomodulatoRy agEnt using self-injecting device) study was designed to evaluate the changes in QL of Italian adolescents with RRMS receiving treatment with IFN-β1a (Rebif; 22 μg), administered subcutaneously three times weekly using the RebiSmart™ electronic autoinjection device over a 52-week period...
August 22, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28822119/five-questions-answered-a-review-of-autologous-hematopoietic-stem-cell-transplantation-for-the-treatment-of-multiple-sclerosis
#18
REVIEW
Harold L Atkins, Mark S Freedman
Multiple sclerosis (MS) is thought to be an autoimmune disease targeting the central nervous system leading to demyelination, and axonal and neuronal damage, resulting in progressive disability. More intensive therapies such as immunodepletion with hematopoietic stem-cell rescue are being used at a time prior to patients becoming irreversibly disabled. Over the last 15 years, there has been a shift away from using autologous hematopoietic stem-cell transplants (aHSCT) to treat patients with progressive MS, towards treating those with active inflammation and relapses...
August 18, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28817997/positive-impact-of-cladribine-on-quality-of-life-in-people-with-relapsing-multiple-sclerosis
#19
Dayo Afolabi, Christo Albor, Lukasz Zalewski, Dan R Altmann, David Baker, Klaus Schmierer
BACKGROUND: A number of elements of the pivotal 'cladribine tablets treating multiple sclerosis orally' (CLARITY) trial have remained unpublished. OBJECTIVE: To report the impact of cladribine on health-related quality of life (QoL) in people with relapsing multiple sclerosis (pwRMS). METHODS: QoL data from the phase III trial of two different doses (3.5 and 5.15 mg/kg) of oral cladribine in pwRMS were acquired from the European Medicines Agency through Freedom of Information...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28810436/employment-and-multiple-sclerosis-a-meta-analytic-review-of-psychological-correlates
#20
Diana S Dorstyn, Rachel M Roberts, Gregory Murphy, Rebecca Haub
The association between employment and psychological health in adults with multiple sclerosis was examined ( N = 33 studies). Standardised mean differences (Hedges' g) between those employed and those not in the workforce were calculated. Employed peers reported significantly greater quality of life and mood, cited fewer work and multiple sclerosis-related difficulties and were more likely to adopt problem-focused coping strategies, considered to be more effective in managing specific stressors. These data are consistent with the positive by-products of maintaining work with multiple sclerosis...
February 1, 2017: Journal of Health Psychology
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