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Procalcitonin antibiotic treatment

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https://www.readbyqxmd.com/read/29772055/the-role-of-procalcitonin-in-the-diagnosis-and-management-of-infections-in-the-field-of-obstetrics-and-gynecology
#1
Gabriel Levin, Amihai Rottenstreich
We read the editorial by Tujula et al. with great interest (1). They described the role of procalcitonin as biomarker for the diagnosis of infection and monitoring of antibiotic treatment. Despite their meticulous citation data collection, several important issues need further consideration.In their report, the authors have claimed that 'proclacitonin seems to be a useful biomarker for severe bacterial infections and this is likely to be the case also in Obstetrics and Gynecology'. This article is protected by copyright...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29715176/procalcitonin-guidance-in-patients-with-lower-respiratory-tract-infections-a-systematic-review-and-meta-analysis
#2
REVIEW
Juliane Hey, Philippe Thompson-Leduc, Noam Y Kirson, Louise Zimmer, Dana Wilkins, Bernie Rice, Irena Iankova, Alexander Krause, Sophie A Schonfeld, Christopher R DeBrase, Samuel Bozzette, Philipp Schuetz
Although effective for bacterial lower respiratory tract infections (LRTIs), antibiotic treatment is often incorrectly prescribed for non-bacterial LRTIs. Procalcitonin has emerged as a promising biomarker to diagnose bacterial infections and guide antibiotic treatment decisions. As part of a regulatory submission to the U.S. Food and Drug Administration, this systematic review and meta-analysis summarizes the effects of procalcitonin-guided antibiotic stewardship on antibiotic use and clinical outcomes in adult LRTI patients...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29706210/influence-of-antibiotic-prophylaxis-on-the-stability-of-orthodontic-microimplants-a-pilot-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Jan Łyczek, Beata Kawala, Joanna Antoszewska-Smith
INTRODUCTION: The aims of this 2-arm parallel pilot randomized controlled trial were to investigate the influence of antibiotic prophylaxis on the stability of orthodontic microimplants and to evaluate the efficacy of systemic inflammatory marker measurements in detecting infections in tissues surrounding microscrews. METHODS: Orthodontic patients requiring en-masse distalization in the maxilla received antibiotics or a placebo before microimplant placement. Eligibility criteria included 13 years of age, and good general and oral health...
May 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29695883/antibiotic-stewardship-interventions-in-hospitals-in-low-and-middle-income-countries-a-systematic-review
#4
REVIEW
Christophe Van Dijck, Erika Vlieghe, Janneke Arnoldine Cox
Objective: To review the effectiveness of antibiotic stewardship interventions in hospitals in low- and middle-income countries. Methods: We searched MEDLINE®, Embase®, Cochrane Central Register of Controlled Trials and regional indexes for studies of interventions to improve appropriate prescribing and use of antibiotics for hospitalized patients in low- and middle-income countries. We included controlled trials, controlled before-and-after studies and interrupted time-series studies published up to December 2017...
April 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29675987/the-usage-of-procalcitonin-in-finland
#5
B Tujula, M Kokki, K Pulkki, J Romppanen, S Sjövall, H Tuominen, H Kokki
BACKGROUND: We have surveyed the use of procalcitonin (PCT) in Finland with a specific emphasis on intensive care unit (ICU) patients. METHODS: The PCT use was surveyed from all 11 laboratories providing services for all 15 secondary and all five tertiary care hospitals in Finland. The laboratories reported the PCT use of each hospital in 2014 and 2015. Four hospitals were analysed for the first 100 adult ICU patients with PCT measurements in 2015. The indication for PCT measurement and whether PCT values affected antibiotic treatment were collected from patient records...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29622524/evaluation-of-procalcitonin-assay-on-the-abbott-architect-i2000-sr%C3%A2-analyzer
#6
Ahmed El Mouatani, Irina Rotaru, Jean-Louis Beaudeux, Carole Hennequin
Procalcitonin (PCT) is a useful biomarker for the diagnosis of bacterial infection. Its measurement is used routinely as a valuable tool for antibiotic treatment decision. The aim of this study is to assess the analytical performance of the new Architect Brahms PCT® reagents on the Abbott Architect i2000-SR® immuno-analyzer. The Architect PCT® assay was evaluated according to the modified SFBC protocol, in accordance with the NF EN ISO 15189 standard. Sixty two samples from patients hospitalized in Necker Hospital (Paris) have been tested with the evaluated method, and results were compared to those of the PCT Kryptor Brahms® method...
April 5, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29607626/drug-fever-and-acute-inflammation-via-hypercytokinemia-triggered-by-dipeptidyl-peptidase-4-inhibitor-vildagliptin
#7
Takatoshi Anno, Hideaki Kaneto, Fumiko Kawasaki, Ryo Shigemoto, Yumi Aoyama, Kohei Kaku, Niro Okimoto
A 69-year-old man started taking dipeptidyl peptidase-4 inhibitor vildagliptin. One week later, C-reactive protein (CRP) and plasma immunoglobulin E levels were markedly elevated, and we stopped vildagliptin. After his laboratory findings were normalized, we challenged to re-start vildagliptin under the patient's agreement. Next day he had a high fever, and CRP and procalcitonin levels were elevated. Although we failed to find infection focus, we started antibiotics therapy. Two days later, high fever was improved, and CRP level was decreased...
April 1, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29592983/rare-cause-of-fever-of-unknown-origin-gastrointestinal-stromal-tumour
#8
Manjunath Havalappa Dodamani, Rajiv Ranjan Kumar, Mayur Parkhi, Rajendar Basher
A 44-year-old man presented with fever (low to high grade) for 2-month duration despite treatment with oral antibiotics and antipyretics. Further, enquiry did not yield any potentially explanatory clues to a diagnosis. Physical examination revealed only left axillary lymphadenopathy, but was otherwise unremarkable. A number of diagnosis included tuberculosis, malignancy, lymphoma, connective disease disorder and infective endocarditis. Further evaluation revealed severe anaemia due to iron deficiency which was supported with blood transfusion and oral iron supplementation...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29571718/c-reactive-protein-response-patterns-after-antibiotic-treatment-among-children-with-scalds
#9
Ingrid Steinvall, Matilda Karlsson, Moustafa Elmasry
BACKGROUND: Scalds are the most common cause of burns in children, yet there is little information available about the inflammatory response. The aim of the study was to investigate the response to treatment with antibiotics among scalded children by following the C-reactive protein (CRP) concentration, procalcitonin (PCT) concentration, and white blood cell count (WCC) during the first two weeks after injury. METHODS: All children with scalds who presented to the Burn Centre during 2010-2016 were included in this retrospective study...
March 20, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29569104/individualising-therapy-to-minimize-bacterial-multidrug-resistance
#10
REVIEW
A J Heffernan, F B Sime, J Lipman, J A Roberts
The scourge of antibiotic resistance threatens modern healthcare delivery. A contributing factor to this significant issue may be antibiotic dosing, whereby standard antibiotic regimens are unable to suppress the emergence of antibiotic resistance. This article aims to review the role of pharmacokinetic and pharmacodynamic (PK/PD) measures for optimising antibiotic therapy to minimise resistance emergence. It also seeks to describe the utility of combination antibiotic therapy for suppression of resistance and summarise the role of biomarkers in individualising antibiotic therapy...
March 22, 2018: Drugs
https://www.readbyqxmd.com/read/29544449/development-and-validation-of-a-diagnostic-model-for-early-differentiation-of-sepsis-and-non-infectious-sirs-in-critically-ill-children-a-data-driven-approach-using-machine-learning-algorithms
#11
Florian Lamping, Thomas Jack, Nicole Rübsamen, Michael Sasse, Philipp Beerbaum, Rafael T Mikolajczyk, Martin Boehne, André Karch
BACKGROUND: Since early antimicrobial therapy is mandatory in septic patients, immediate diagnosis and distinction from non-infectious SIRS is essential but hampered by the similarity of symptoms between both entities. We aimed to develop a diagnostic model for differentiation of sepsis and non-infectious SIRS in critically ill children based on routinely available parameters (baseline characteristics, clinical/laboratory parameters, technical/medical support). METHODS: This is a secondary analysis of a randomized controlled trial conducted at a German tertiary-care pediatric intensive care unit (PICU)...
March 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29530360/utility-of-initial-procalcitonin-values-to-predict-urinary-tract-infection
#12
Alexander R Levine, Midori Tran, Jonathan Shepherd, Edgar Naut
BACKGROUND: Urinary tract infections (UTIs) are one of the most common reasons women seek treatment in the emergency department (ED). The biomarker procalcitonin (PCT) has gained popularity over the last decade to improve the diagnosis of bacterial infections and reduce unnecessary exposure to antibiotics. PCT has been extensively studied in patients with pneumonia and sepsis and may have additional role in UTI. METHODS: A retrospective study of patients who presented to the ED in which a urinalysis test and a PCT level was obtained within the first 24h of presentation...
March 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29528854/the-role-of-procalcitonin-in-the-management-of-pleural-infection
#13
Duneesha de Fonseka, Nick A Maskell
PURPOSE OF REVIEW: Pleural infection is a common problem associated with significant morbidity and mortality. Systemic or pleural fluid markers for reliably identifying pleural infection are limited. Procalcitonin (PCT) is known to be elevated in bacterial infection and is currently used for diagnosis and decision-making regarding antibiotic duration in respiratory infections. This review investigates if there is a role for serum and pleural fluid PCT (pf-PCT) in diagnosis and management of pleural infection...
March 9, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29523046/serum-procalcitonin-levels-together-with-clinical-features-and-inflammatory-markers-in-women-with-tubo-ovarian-abscess-for-discriminating-requirements-for-surgery-for-full-recovery
#14
Kenan Karaca, Enis Ozkaya, Meryem Kurek Eken, Ilgi Uygun, Sule Yıldırım Kopuk, Murat Alpay
Tubo-ovarian abscess (TOA) coexists in 15% of cases with pelvic inflammatory disease. Medical treatment is the first line of approach in women with TOA, however, 25% of cases fail to respond to antibiotics, therefore, these cases need to undergo surgical intervention. We aimed to determine factors leading to failure of medical treatment in women diagnosed with TOA. According to our results among 144 women, 27 cases required surgical intervention for full recovery. None of the demographic, sonographic or laboratory findings, including procalcitonin level, had significant predictive value for the failure of medical treatment in women with TOA...
March 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29519283/-effect-of-lateral-position-ventilation-combined-with-vibration-sputum-drainage-on-patients-with-acute-respiratory-distress-syndrome-a-prospective-randomized-controlled-trial
#15
Lingchen Kong, Jianzhong Li, Peng Wu, Jianhua Xu, Honglei Li, Haifei Long, Pan Liu, Fangfang Wei, Wenhong Peng
OBJECTIVE: To investigate the curative effect of lateral position ventilation combined with vibration sputum drainage on the patients with acute respiratory distress syndrome (ARDS). METHODS: A prospective randomized controlled trial was conducted. The patients with ARDS undergoing mechanical ventilation (MV) admitted to intensive care unit (ICU) of Linyi Central Hospital from January 2013 to June 2017 were enrolled, and they were divided into simple ventilation group and combined treatment group according to random number table...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29516022/time-course-of-c-reactive-protein-and-procalcitonin-levels-during-the-treatment-of-acute-bacterial-skin-infections
#16
Timothy C Jenkins, Jason S Haukoos, Eleanor Cotton, David Weitzenkamp, Daniel N Frank, William J Burman
In a pilot study of 22 patients with an acute bacterial skin infection, serum levels of C-reactive protein and procalcitonin tended to be elevated at presentation and declined within 3-5 days of treatment. Further study of a biomarker-guided treatment strategy to reduce antibiotic overuse in skin infections is warranted.
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29512600/a-meta-analysis-to-assess-usefulness-of-procalcitonin-guided-antibiotic-usage-for-decision-making
#17
REVIEW
Nusrat Shafiq, Vikas Gautam, Avaneesh Kumar Pandey, Navjot Kaur, Shubha Garg, Harish Negi, Sharonjeet Kaur, Pallab Ray, Samir Malhotra
Background & objectives: Development of antibacterial resistance and its association with antibiotic overuse makes it necessary to identify a specific and sensitive biomarker for the diagnosis of bacterial infection and guiding antibiotic therapy. Procalcitonin (PCT), as a sepsis biomarker, may play a role in guiding antibiotics treatment in hospital settings. The aim of the current meta-analysis was to analyze the utility of PCT on various outcomes of interest in inpatients. Methods: Different databases were searched for randomized controlled trials comparing PCT-guided therapy with standard therapy in admitted patients with bacterial infections...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29506460/clinical-pulmonary-infection-score-and-a-spot-serum-procalcitonin-level-to-guide-discontinuation-of-antibiotics-in-ventilator-associated-pneumonia-a-study-in-a-single-institution-with-high-prevalence-of-nonfermentative-gram-negative-bacilli-infection
#18
Phunsup Wongsurakiat, Sirapat Tulatamakit
Background We wanted to determine the impact of combined Clinical Pulmonary Infection Score (CPIS) and a spot serum procalcitonin (PCT)-guided protocol to shorten the duration of antibiotic treatment in patients with ventilator-associated pneumonia (VAP), mainly caused by nonfermentative gram-negative bacilli (NF-GNB). Methods Patients with VAP who received appropriate antibiotics for 7 days, temperature ⩽ 37.8°C, without shock, and CPIS ⩽ 6 were allocated to the PCT group or conventional group according to the treating physicians' decisions...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29399566/predictive-value-of-procalcitonin-for-infection-and-survival-in-adult-cardiogenic-shock-patients-treated-with-extracorporeal-membrane-oxygenation
#19
Do Wan Kim, Hwa Jin Cho, Gwan Sic Kim, Sang Yun Song, Kook Joo Na, Sang Gi Oh, Bong Suk Oh, In Seok Jeong
Procalcitonin (PCT) is a predictive marker for the occurrence of bacterial infection and the decision to terminate antibiotic treatment in critically ill patients. An unusual increase in PCT, regardless of infection, has been observed during extracorporeal membrane oxygenation (ECMO) support. We evaluated trends and the predictive value of PCT levels in adult cardiogenic shock during treatment with ECMO. We reviewed the clinical records of 38 adult cardiogenic shock patients undergoing veno-arterial ECMO support between January 2014 and December 2016...
January 2018: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29373980/do-we-need-new-trials-of-procalcitonin-guided-antibiotic-therapy
#20
Thiago Lisboa, Jorge Salluh, Pedro Povoa
Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect of a procalcitonin (PCT)-guided antibiotic treatment on outcomes in acute lower respiratory tract infections (LRTI), suggesting that significant reductions in antibiotic duration occur when using a PCT-guided algorithm. However, controversial evidence also suggested PCT-guided algorithms were associated with increased antibiotic duration and increased incidence of Clostridium difficile, without any impact on mortality, in real-world settings...
January 27, 2018: Critical Care: the Official Journal of the Critical Care Forum
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