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Phytochemical medicine

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https://www.readbyqxmd.com/read/29331816/new-robust-sensitive-fluorescence-spectroscopy-coupled-with-plsr-for-estimation-of-quercetin-in-ziziphus-mucronata-and-ziziphus-sativa
#1
Javid Hussain, Fazal Mabood, Ahmed Al-Harrasi, Liaqat Ali, Tania Shamim Rizvi, Farah Jabeen, Syed Abdullah Gilani, Shehla Shinwari, Mushtaq Ahmad, Zahra Khalfan Alabri, Said Hamood Salim Al Ghawi
Flavonoids are natural antioxidants derived from plants and commonly found in a variety of foods to sequester free radicals. Quercetin, belonging to flavonol subclass of flavonoids, has received considerable attention because of its wide uses as a nutritional supplement as well as a phytochemical remedy for a number of diseases. In the current study, quantification of quercetin was carried out in two medicinally important flavonoid rich plant Ziziphus mucronata and Ziziphus sativa. Emission spectroscopy was utilized as a new method coupled with Partial Least Squares Regression (PLSR) and the cross validation was done by UV-Visible spectroscopy...
January 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331316/pharmacological-activities-of-the-organic-extracts-and-chemical-fatty-acids-composition-of-the-petroleum-ether-extract-from-haplophyllum-tuberculatum-leaves
#2
Assia Hamdi, Kaouther Majouli, Amal Abdelhamid, Hela Belghith, Imed Chraief, Abderrahman Bouraoui, Zohra Marzouk, Yvan Vander Heyden
ETHNOPHARMACOLOGICAL RELEVANCE: Haplophyllum tuberculatum is used in traditional medicine to treat many disorders including inflammation and pain. The aim of this study is to investigate the organic extracts from H. tuberculatum leaves against inflammation, gastric ulcer and pain. MATERIALS AND METHODS: Acute toxicity was studied in vivo to determine the toxic doses of the leaves organic extracts. Anti-inflammatory activity was also evaluated in vivo using carrageenan-induced paw edema in Wistar rats...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29329607/the-genus-liriope-phytochemistry-and-pharmacology
#3
Zhan-Peng Shang, Fei Wang, Jia-Yu Zhang, Zi-Jian Wang, Jian-Qiu Lu, Huai-You Wang, Ning Li
Liriope (Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants (8 species), a total of 132 compounds (except polysaccharides) have been isolated and identified, including steroidal saponins, flavonoids, phenols, and eudesmane sesquiterpenoids. The crude extracts or monomeric compounds from this genus have been shown to exhibit anti-tumor, anti-diabetic, anti-inflammatory, and neuroprotective activities. The present review summarizes the results on phytochemical and biological studies on Liriope plants...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29325915/in-vivo-nonspecific-immunomodulatory-and-antispasmodic-effects-of-common-purslane-portulaca-oleracea-linn-leaf-extracts-in-icr-mice
#4
Elena S Catap, Markyn Jared L Kho, Maria Rexie R Jimenez
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea (common purslane) is used in traditional medicine to cure various illnesses. However, its immune-protective properties and antispasmodic effects still need more pharmacological data if the plant will be utilized in herbal and drug formulations. Therefore, the present study determined the capacity of this plant species to modulate nonspecific immune responses and to confirm its antispasmodic activity in vivo in ICR mice. MATERIALS AND METHODS: Phagocytic activity of peritoneal macrophage, splenic lymphocyte proliferation and plasma lysozyme levels were measured in mice that were immunosuppressed using cyclophosphamide and treated with the ethyl acetate extract of Portulaca oleracea...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29321986/traditional-uses-and-pharmacological-properties-of-clerodendrum-phytochemicals
#5
REVIEW
Jin-Hui Wang, Fei Luan, Xiang-Dong He, Yong Wang, Mao-Xing Li
Clerodendrum is a genus of ca. 500 species in the family Lamiaceae and widely distributed throughout the whole world. Up to now, many species of this genus have been described in various indigenous systems of medicine and are used in preparation of folklore medicines for the treatment of various life-threatening diseases, and more than eleven species of the Clerodendrum genus have been very well studied for their chemical constituents and biological activities, and 283 compounds, including monoterpene and its derivatives, sesquiterpene, diterpenoids, triterpenoids, flavonoid and flavonoid glycosides, phenylethanoid glycosides, steroids and steroid glycosides, cyclohexylethanoids, anthraquinones, cyanogenic glycosides, and others have been isolated and identified...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29320554/a-census-of-p-longum-s-phytochemicals-and-their-network-pharmacological-evaluation-for-identifying-novel-drug-like-molecules-against-various-diseases-with-a-special-focus-on-neurological-disorders
#6
Neha Choudhary, Vikram Singh
Piper longum (P. longum, also called as long pepper) is one of the common culinary herbs that has been extensively used as a crucial constituent in various indigenous medicines, specifically in traditional Indian medicinal system known as Ayurveda. For exploring the comprehensive effect of its constituents in humans at proteomic and metabolic levels, we have reviewed all of its known phytochemicals and enquired about their regulatory potential against various protein targets by developing high-confidence tripartite networks consisting of phytochemical-protein target-disease association...
2018: PloS One
https://www.readbyqxmd.com/read/29316948/traditional-uses-of-medicinal-plants-practiced-by-the-indigenous-communities-at-mohmand-agency-fata-pakistan
#7
Muhammad Abdul Aziz, Muhammad Adnan, Amir Hasan Khan, Abdelaaty Abdelaziz Shahat, Mansour S Al-Said, Riaz Ullah
BACKGROUND: Plant-derived products have an imperative biological role against certain pathogenic organisms and were considered to be a major source of modern drugs. Rural people residing in developing countries are relying on traditional herbal medical system due to their strong believe and minimum access to allopathic medicines. Hence, ethnomedicinal knowledge is useful for the maintenance of community's based approaches under this medical system. Present study was carried out in an unexplored remote tribal area of Pakistan to investigate and document the existing ethnomedicinal knowledge on local flora...
January 9, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29316691/a-comparative-study-on-phytochemical-profiles-and-biological-activities-of-sclerocarya-birrea-a-rich-hochst-leaf-and-bark-extracts
#8
Daniela Russo, Rocchina Miglionico, Monica Carmosino, Faustino Bisaccia, Paula B Andrade, Patrícia Valentão, Luigi Milella, Maria Francesca Armentano
Sclerocarya birrea (A.Rich.) Hochst (Anacardiaceae) is a savannah tree that has long been used in sub-Saharan Africa as a medicinal remedy for numerous ailments. The purpose of this study was to increase the scientific knowledge about this plant by evaluating the total content of polyphenols, flavonoids, and tannins in the methanol extracts of the leaves and bark (MLE and MBE, respectively), as well as the in vitro antioxidant activity and biological activities of these extracts. Reported results show that MLE is rich in flavonoids (132...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315936/biosynthesis-of-bioactive-diterpenoids-in-the-medicinal-plant-vitex-agnus-castus
#9
Allison Maree Heskes, Tamil C M Sundram, Berin Alain Boughton, Niels Bjerg Jensen, Nikolaj Lervad Hansen, Christoph Crocoll, Federico Cozzi, Simon Rasmussen, Britta Hamberger, Björn Hamberger, Dan Staerk, Birger Lindberg Møller, Irini Pateraki
Vitex agnus-castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders and is still used today as a clinically effective treatment for premenstrual syndrome. The pharmaceutical activity of the plant extract is linked to its ability to lower prolactin levels. This feature has been attributed to the presence of dopaminergic diterpenoids that can bind to dopamine receptors in the pituitary gland. Phytochemical analyses of V. agnus-castus show that it contains an enormous array of structurally related diterpenoids and, as such holds potential as a rich source of new dopaminergic drugs...
January 8, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29311454/-development-of-plant-metabolomics-and-medicinal-plant-genomics
#10
Kazuki Saito
 A variety of chemicals produced by plants, often referred to as 'phytochemicals', have been used as medicines, food, fuels and industrial raw materials. Recent advances in the study of genomics and metabolomics in plant science have accelerated our understanding of the mechanisms, regulation and evolution of the biosynthesis of specialized plant products. We can now address such questions as how the metabolomic diversity of plants is originated at the levels of genome, and how we should apply this knowledge to drug discovery, industry and agriculture...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29307753/tetraglochin-cristatum-britton-roth-a-medicinal-plant-from-the-argentinean-highlands-with-potential-use-in-vaginal-candidiasis
#11
María Alejandra Moreno, Susana Córdoba, Iris Catiana Zampini, María Rosa Alberto, M E Fatima Nader-Macias, Jorge Sayago, Alberto Burgos-Edwards, Guillermo Schmeda-Hirschmann, María Inés Isla
ETHNOPHARMACOLOGICAL RELEVANCE: The Argentinean medicinal plant Tetraglochin cristatum (Britton) Rothm is used in traditional medicine by inhabitants from Argentinean northwestern highlands (Puna) to treat candidiasis and as anti-inflammatory. AIM OF THE STUDY: To assess the potential of the crude drug as an anti-Candida agent with anti-inflammatory properties. The bioactivity and phytochemical composition of a dry extract of the plant was investigated. MATERIAL AND METHODS: A hydroalcoholic dry extract from T...
January 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29307662/moringa-oleifera-phytochemicals-protect-the-brain-against-experimental-nicotine-induced-neurobehavioral-disturbances-and-cerebellar-degeneration
#12
Gabriel Olaiya Omotoso, Ismail Temitayo Gbadamosi, Olayemi Joseph Olajide, Shakirat Opeyemi Dada-Habeeb, Tolulope Timothy Arogundade, Emmanuel Olusola Yawson
Nicotine is a neuro-stimulant that has been implicated in the pathophysiology of many brain diseases. The need to prevent or alleviate the resulting dysfunction is therefore paramount, which has also given way to the use of medicinal plants in the management of brain conditions. This study was designed to determine the histomorphological and neurobehavioural changes in the cerebellum of Wistar rats following nicotine insult and how such injuries respond to Moringa intervention. Twenty-four adult male Wistar rats were divided into 4 groups...
January 4, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29303617/ethnobotanical-phytochemical-and-therapeutic-effects-of-myrtus-communis-l-berries-seeds-on-gastrointestinal-tract-diseases-a-review
#13
Mohamed-Amine Jabri, Lamjed Marzouki, Hichem Sebai
Medicinal plants have always had an important place in the therapeutic arsenal of humanity and particularly in the treatment of gastrointestinal tract diseases. Myrtus communis L., known as common myrtle, is native to Southern Europe, North Africa, and Western Asia. The different parts of this plant are used as antiinflammatory, antiulcer, antidiabetic, urinary antiseptic, and to treat the respiratory and digestive systems diseases. For the first time, an exhaustive bibliographic research of the seeds of myrtle berries has been carried out...
January 5, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29302624/chemical-composition-and-antifungal-effect-of-hydroalcoholic-extract-of-allium-tripedale-tvautv-against-candida-species
#14
M Shirani, A Samimi, H Kalantari, M Madani, A Kord Zanganeh
Background and Purpose: Treatment of life-threatening fungal infections caused by Candida species has become a major problem. Candida spp. are the most important causative agents of candidiasis. Allium tripedale is a medicinal plant that has been traditionally used to treat infections. In the present study, we aimed to determine the chemical compounds and antimicrobial activity of hydroalcoholic extract of A. tripedale against different species of Candida. Materials and Methods: Phytochemical analysis was performed to identify the possible bioactive components of this extract by using gas chromatography and mass spectroscopy (GC-MS)...
March 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29301523/genoprotective-antioxidant-antifungal-and-anti-inflammatory-evaluation-of-hydroalcoholic-extract-of-wild-growing-juniperus-communis-l-cupressaceae-native-to-romanian-southern-sub-carpathian-hills
#15
Irina Fierascu, Camelia Ungureanu, Sorin Marius Avramescu, Carmen Cimpeanu, Mihaela Ioana Georgescu, Radu Claudiu Fierascu, Alina Ortan, Anca Nicoleta Sutan, Valentina Anuta, Anca Zanfirescu, Cristina Elena Dinu-Pirvu, Bruno Stefan Velescu
BACKGROUND: Juniperus communis L. represents a multi-purpose crop used in the pharmaceutical, food, and cosmetic industry. Several studies present the possible medicinal properties of different Juniperus taxa native to specific geographical area. The present study aims to evaluate the genoprotective, antioxidant, antifungal and anti-inflammatory potential of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills. METHODS: The prepared hydroethanolic extract of Juniperus communis L...
January 4, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29299990/aqueous-extract-of-argania-spinosa-l-fruits-ameliorates-diabetes-in-streptozotocin-induced-diabetic-rats
#16
Mohamed Eddouks, Hebi Morad
INTRODUCTION: The argan tree (Argania spinosa L.) is an endemic species from south-western Morocco. Argan-based preparations have been widely used in Moroccan traditional medicine for their biological properties including diabetes especially argan oil. However, the antihypergycemic effect of the pericarp of A. spinosa fruit has never been evaluated. OBJECTIVE: The purpose of this study was to investigate the effect of a single dose and daily oral administration for seven days of aqueous extract of pericarp of Argania spinosa fruit (A...
January 3, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29295712/hplc-dad-finger-printing-antioxidant-cholinesterase-and-%C3%AE-glucosidase-inhibitory-potentials-of-a-novel-plant-olax-nana
#17
Muhammad Ovais, Muhammad Ayaz, Ali Talha Khalil, Sayed Afzal Shah, Muhammad Saeed Jan, Abida Raza, Muhammad Shahid, Zabta Khan Shinwari
BACKGROUND: The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesterase, and α-glucosidase inhibitory assays. METHODS: The crude methanolic extract of O. nana (ON-Cr) was subjected to qualitative phytochemical analysis and HPLC-DAD finger printing. The antioxidant potential of ON-Cr was assessed via 1,1-diphenyl,2-picrylhydrazyl (DPPH), 2,2-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS) and hydrogen peroxide (H2O2) free radical scavenging assays...
January 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29291443/prenylated-flavonoids-as-potent-phosphodiesterase-4-inhibitors-from-morus-alba-isolation-modification-and-structure-activity-relationship-study
#18
Yan-Qiong Guo, Gui-Hua Tang, Lan-Lan Lou, Wei Li, Bei Zhang, Bo Liu, Sheng Yin
The bioassay-guided phytochemical study of a traditional Chinese medicine Morus alba led to the isolation of 18 prenylated flavonoids (1-18), of which (±)-cyclomorusin (1/2), a pair of enantiomers, and 14-methoxy-dihydromorusin (3) are the new ones. Subsequent structural modification of the selected components by methylation, esterification, hydrogenation, and oxidative cyclization led to 14 more derivatives (19-32). The small library was screened for its inhibition against phosphodiesterase-4 (PDE4), which is a drug target for the treatment of asthma and chronic obstructive pulmonary disease (COPD)...
December 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29289692/activation-of-nrf2-signaling-by-natural-products-can-it-alleviate-diabetes
#19
REVIEW
Manuel Matzinger, Katrin Fischhuber, Elke H Heiss
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor boosting cytoprotective responses, and many phytochemicals activate Nrf2 signaling. Thus, Nrf2 activation by natural products could presumably alleviate DM. We summarize function, regulation and exogenous activation of Nrf2, as well as diabetes-linked and Nrf2-susceptible forms of cellular stress...
December 28, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29289576/botanicals-and-phytochemicals-active-on-cognitive-decline-the-clinical-evidence
#20
REVIEW
Arrigo F G Cicero, Federica Fogacci, Maciej Banach
Beyond the well-known effects on cognitive impairment of the Mediterranean diet, a number of studies have investigated the possible action on cognitive decline of different botanicals and phytochemicals, most of which are well-known anti-inflammatory or antioxidant agents with a good tolerability and safety profile. In particular, the current literature supports the use of Ginkgo biloba, resveratrol, epigallocatechin-3-gallate and l-theanine, Theobroma cacao, Bacopa monnieri, Crocus sativus and curcumin, which might have a positive impact on cognitive impairment used alone or in combination with other nutraceuticals or traditional drugs...
December 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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