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Phytochemical medicine

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https://www.readbyqxmd.com/read/28087472/extract-of-clinopodium-bolivianum-protects-against-e-coli-invasion-of-uroepithelial-cells
#1
Soumitra Mohanty, Witchuda Kamolvit, Silvia Zambrana, Corine Sandström, Eduardo Gonzales, Claes-Göran Östenson, Annelie Braunerf
ETHNOPHARMACOLOGICAL RELEVANCE: Clinopodium bolivianum is a South American plant with anti-inflammatory and anti-infective activities. The increasing antibiotic resistance urges for alternative therapy. Based on its use in traditional medicine, we investigated the effect of C. bolivianum on the ability to defend bladder epithelial cells from E. coli infection. MATERIALS AND METHODS: The extract was analysed by LC-MS. Bladder epithelial cell lines T24 and 5637 and uropathogenic E...
January 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28078497/anti-inflammatory-effect-of-naravelia-zeylanica-dc-via-suppression-of-inflammatory-mediators-in-carrageenan-induced-abdominal-oedema-in-zebrafish-model
#2
Sanmuga Priya Ekambaram, Senthamil Selvan Perumal, Selvaranjani Pavadai
The traditional herbal medicines are receiving great importance in the health care sector, especially in Indian system of medicine, i.e, Ayurveda. The present study focused on the standardization of Naravelia zeylanica (L.) DC in terms of its active phytochemicals and to evaluate the anti-inflammatory activity of ethanol extract of N. zeylanica (ENZ). An analytical method was developed by high-performance liquid chromatography for simultaneous determination of β-sitosterol, lupeol and oleanolic acid in ENZ...
January 11, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28078247/effects-of-biebersteinia-multifida-hydro-ethanol-extract-on-proliferation-and-apoptosis-of-human-prostate-cancer-and-human-embryonic-kidney-cells
#3
Alireza Golshan, Samira Hassanzadeh, Maryam Mojdekanloo, Zahra Tayarani-Najaran
OBJECTIVE: Biebersteinia (Geraniaceae) has a history of use in traditional medicine in some countries including Iran. In the present study, cytotoxic and apoptogenic properties of hydro-ethanol extract of B. multifidi was investigated on human prostate cancer cell lines (PC3 and DU 145) and human embryonic kidney 293 (HEK293) cells. MATERIALS AND METHODS: Cells were cultured in RPMI-1640 medium supplemented with 10% FBS at 37ºC in a humidified atmosphere of 95% air and 5% CO2...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28078245/the-effects-of-cinnamaldehyde-and-eugenol-on-human-adipose-derived-mesenchymal-stem-cells-viability-growth-and-differentiation-a-cheminformatics-and-in-vitro-study
#4
Abdorrahim Absalan, Seyed Alireza Mesbah-Namin, Taki Tiraihi, Taher Taheri
OBJECTIVE: The aim of this study was to estimate the cheminformatics and qualitative structure-activity relationship (QSAR) of cinnamaldehyde and eugenol. The effects of cinnamaldehyde and eugenol on the viability, doubling time and adipogenic or osteogenic differentiations of human adipose-derived mesenchymal stem cells (hASCs) were also investigated. MATERIALS AND METHODS: QSAR and toxicity indices of cinnamaldehyde and eugenol were evaluated using cheminformatics tools including Toxtree and Toxicity Estimation Software Tool (T...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28074665/diterpenoid-alkaloids-from-the-root-of-aconitum-sinchiangense-w-t-wang-with-their-antitumor-and-antibacterial-activities
#5
Xiaoxia Liang, Lan Chen, Lei Song, Wenbo Fei, Min He, Changliang He, Zhongqiong Yin
A phytochemical study of the root barks of Aconitum sinchiangense W. T. Wang, a traditional Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new C19-diterpenoid alkaloid, sinchiangensine A (1), whose structure was determined by spectral methods including 2D NMR. Additionally, sinchiangensine A and its known analogue 3 were first reported as potential antitumor and antibacterial diterpenoid alkaloids, which showed significant antitumor activities against tumour cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC50 comparable to cisplatin, and significant antibacterial activities against Staphylococcus aureus ATCC-25923 with MIC value of 0...
January 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28073097/moringa-oleifera-a-species-with-potential-analgesic-and-anti-inflammatory-activities
#6
Claudia Lizbeth Martínez-González, Laura Martínez, Efraín J Martínez-Ortiz, María Eva González-Trujano, Myrna Déciga-Campos, Rosa Ventura-Martínez, Irene Díaz-Reval
Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents' nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30-300mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067965/rp-hplc-dad-esi-qtof-ms-based-metabolic-profiling-of-the-potential-olea-europaea-by-product-wood-and-its-comparison-with-leaf-counterpart
#7
Sonda Ammar, Maria Del Mar Contreras, Boutheina Gargouri, Antonio Segura-Carretero, Mohamed Bouaziz
INTRODUCTION: Olea europaea L. organs such as leaves, stems and roots have been associated with numerous in vivo and in vitro biological activities and used for traditional medicinal purposes. However, tree wood is an untapped resource with little information about their chemical composition. OBJECTIVE: That is why, the objective of this study is to increase the knowledge about phytochemicals from 'Chemlali' olive wood by means of mass spectrometry-based analyses...
January 9, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28065777/protective-effects-of-petroleum-ether-extracts-of-herpetospermum-caudigerum-against-%C3%AE-naphthylisothiocyanate-induced-acute-cholestasis-of-rats
#8
Wen-Rui Cao, Jing-Qiu Ge, Xin Xie, Meng-Lin Fan, Xu-Dong Fan, Hong Wang, Zhao-Yue Dong, Zhi-Hua Liao, Xiao-Zhong Lan, Min Chen
ETHNOPHARMACOLOGICAL RELEVANCE: The ripe seeds of Herpetospermum caudigerum have been used in Tibetan folk medicine for treatment of bile or liver diseases including jaundice, hepatitis, intumescences or inflammation. Previously reports suggested that the seed oil and some lignans from H. caudigerum exhibited protective effects against carbon tetrachloride (CCl4)-induced hepatic damage in rats, which may be related to their free radical scavenging effect. However, the protective effect of H...
January 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28061888/antibacterial-activities-of-the-methanol-extract-fractions-and-compounds-from-elaeophorbia-drupifera-thonn-stapf-euphorbiaceae
#9
Igor K Voukeng, Blaise K Nganou, Louis P Sandjo, Ilhami Celik, Veronique P Beng, Pierre Tane, Victor Kuete
BACKGROUND: Elaeophorbia drupifera (Thonn.) Stapf. (Euphorbiaceae) is used in Cameroonian folk medicine to treat several ailments including bacterial-related diseases such as skin infections. In this study, the methanol extract from the leaves (EDL), fractions (EDLa-d), sub-fractions EDLc1-7 and EDLc31-35 as well as isolated compounds were tested for their antimicrobial activities against a panel of Gram-negative and Gram-positive bacteria including multidrug resistant (MDR) phenotypes...
January 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056939/evaluation-of-anti-inflammatory-activity-of-compounds-isolated-from-the-rhizome-of-ophiopogon-japonicas
#10
Jing-Wen Zhao, Ding-Sheng Chen, Chang-Sheng Deng, Qi Wang, Wei Zhu, Li Lin
BACKGROUND: Ophiopogon japonicas (L.f) Ker-Gawl has been used as a traditional Chinese medicine to cure acute and chronic inflammation and cardiovascular diseases including thrombotic diseases for thousands of years. Previous phytochemical studies showed that O. japonicus contained compounds with anti-inflammatory activity. The aim of this study was to identify and isolate compounds with anti-inflammatory activity from the rhizome of O. japonicas. METHODS: Compounds were isolated by various column chromatography and their structures were identified in terms of nuclear magnetic resonance spectrum (NMR) and mass spectrum (MS)...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056932/in-vivo-antimalarial-activity-of-crude-extracts-and-solvent-fractions-of-leaves-of-strychnos-mitis-in-plasmodium-berghei-infected-mice
#11
Selamawit Fentahun, Eyasu Makonnen, Tesfaye Awas, Mirutse Giday
BACKGROUND: Malaria is a major public health problem in the world which is responsible for death of millions particularly in sub-Saharan Africa. Today, the control of malaria has become gradually more complex due to the spread of drug-resistant parasites. Medicinal plants are the unquestionable source of effective antimalarials. The present study aimed to evaluate antiplasmodial activity and acute toxicity of the plant Strychnos mitis in Plasmodium berghei infected mice. METHODS: Standard procedures were employed to investigate acute toxicity and 4-day suppressive effect of crude aqueous and hydro-methanolic extracts of the leaves of Strychnos mitis against P...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28053890/medicinal-properties-of-terminalia-arjuna-roxb-wight-arn-a%C3%A2-review
#12
REVIEW
Augustine Amalraj, Sreeraj Gopi
Medicinal plants have been a main source of therapeutic agents from ancient time to cure diseases. Terminalia arjuna (Roxb.) Wight & Arn. (T. arjuna) is one of the most accepted and beneficial medicinal plants in indigenous system of medicine for the treatment of various critical diseases. This comprehensive review provides various aspects of its ethnomedical, phytochemical, pharmacognostical, pharmacological and clinical significance to different diseases particularly in cardiovascular conditions. This plant has a good safety outline when used in combination with other conventional drugs...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28052238/anti-psoriatic-potential-of-solanum-xanthocarpum-stem-in-imiquimod-induced-psoriatic-mice-model
#13
Komal M Parmar, Prakash R Itankar, Apurva Joshi, Satyendra K Prasad
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) is one of the members of the dashamula (ten roots) in Ayurvedic system of medicine. The stem and fruits are used as an antipyretic, antiasthmatic and is prescribed in skin infections and for relief in burning sensation in the feet accompanied by vesicular eruptions. OBJECTIVE: To scientifically validate the anti-psoriatic potential of Solanum xanthocarpum stem in Imiquimod-induced psoriatic mice model MATERIALS AND METHODS: Ethanolic stems extract of Solanum xanthocarpum (ESX) was first subjected to phytochemical screening and quantification of identified phytoconstituents, which was further standardized with the help of HPTLC using chlorogenic acid as a marker...
January 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28043897/natural-products-against-alzheimer-s-disease-pharmaco-therapeutics-and-biotechnological-interventions
#14
REVIEW
Abhijit Dey, Raktim Bhattacharya, Anuradha Mukherjee, Devendra Kumar Pandey
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease associated with memory and cognition impairment ultimately leading to death. It is the commonest reason of dementia in elderly populations mostly affecting beyond the age of 65. The pathogenesis is indicated by accumulation of the amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFT) in brain tissues and hyperphosphorylation of tau protein in neurons. The main cause is considered to be the formation of reactive oxygen species (ROS) due to oxidative stress...
December 30, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/28043557/antimycobacterial-potency-and-cytotoxicity-study-of-three-medicinal-plants
#15
Patrick Valere Tsouh Fokou, Regina Appiah-Opong, Dorothy Yeboah-Manu, Abena Adomah Kissi-Twum, Lauve Rachel Tchokouaha Yamthe, Aristide Laurel Mokale Kognou, Phyllis Addo, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
OBJECTIVE/BACKGROUND: Mycobacterial infections including tuberculosis, leprosy, and buruli ulcer are among the most prevalent, debilitating, and deadly tropical diseases, especially in Sub-Saharan Africa. The development of drug resistance to the currently available drugs and the poor compliance emphasize the need for new chemotherapeutic agents. This study was designed to evaluate the in vitro activity of Cleistopholis patens, Annona reticulata, and Greenwayodendron suaveolens against Mycobacterium smegmatis...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043490/antimycobacterial-activity-of-medicinal-plants-against-the-causative-agent-of-buruli-ulcer-mycobacterium-ulcerans
#16
R Keumoe, M S Nguembou, F P V Tsouh, D V F Donkeng, D Dize, Y L R Tchokouaha, M C D Jiatsa, F R D Youmsi, B Ngameni, B F Fekam
OBJECTIVE/BACKGROUND: Buruli ulcer, known as necrotizing skin disease caused by Mycobacterium ulcerans, has emerged as the most prevalent mycobacteriosis after leprosy and tuberculosis. Accordingly, it has been classified by the World Health Organization as a neglected disease with high significance in tropical areas, including Cameroon. So far, the control of the disease relies mainly on the rifampin-streptomycin combination. Despite its efficiency, it has shown considerable issues, including availability and side effects...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28041908/four-new-steroids-from-the-endophytic-fungus-chaetomium-sp-m453-derived-of-chinese-herbal-medicine-huperzia-serrata
#17
Fei-Xue Yu, Zhe Li, Yao Chen, Yin-He Yang, Guo-Hong Li, Pei-Ji Zhao
An endophytic fungus, Chaetomium sp. M453, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation. Three unusual C25 steroids, neocyclocitrinols E-G (1-3), and 3β-hydroxy-5,9-epoxy-(22E,24R)-ergosta-7,22-dien-6-one (4) together with three known steroids were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS experiments. The absolute configuration of 1 was determined by X-ray crystallographic analysis and CD analyses...
December 29, 2016: Fitoterapia
https://www.readbyqxmd.com/read/28040797/disease-subtype-independent-biomarkers-of-breast-cancer-chemoprevention-by-the-ayurvedic-medicine-phytochemical-withaferin-a
#18
Suman K Samanta, Anuradha Sehrawat, Su-Hyeong Kim, Eun-Ryeong Hahm, Yongli Shuai, Ruchi Roy, Subrata K Pore, Krishna B Singh, Susan M Christner, Jan H Beumer, Nancy E Davidson, Shivendra V Singh
BACKGROUND: A nontoxic chemopreventive intervention efficacious against different subtypes of breast cancer is still a clinically unmet need. The present study was undertaken to determine the efficacy of an Ayurvedic medicine phytochemical (Withaferin A, [WA]) for chemoprevention of breast cancer and to elucidate its mode of action. METHODS: Chemopreventive efficacy of WA (4 and 8 mg/kg body weight) was determined using a rat model of breast cancer induced by N-methyl-N-nitrosourea (MNU; n = 14 for control group, n = 15 for 4 mg/kg group, and n = 18 for 8 mg/kg group)...
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28031778/evaluation-of-extraction-protocols-for-anti-diabetic-phytochemical-substances-from-medicinal-plants
#19
Stanley Irobekhian Reuben Okoduwa, Ismaila A Umar, Dorcas B James, Hajara M Inuwa, James D Habila
AIM: To examine the efficacy of three extraction techniques: Soxhlet-extraction (SE), cold-maceration (CM) and microwave-assisted-extraction (MAE) using 80% methanol as solvent. METHODS: The study was performed on each of 50 g of Vernonia amygdalina (VA) and Occimum gratissimum (OG) leaves respectively. The percentage yield, duration of extraction, volume of solvent used, qualitative and quantitative phytoconstituents present was compared. The biological activities (hypoglycemic effect) were investigated using albino wistar rat model of diabetes mellitus (n = 36) with a combined dose (1:1) of the two plants leaf extracts (250 mg/kg b...
December 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/28029062/the-main-constituents-of-tulipa-systola-stapf-roots-and-flowers-their-antioxidant-activities
#20
Mohammed Farhad Ibrahim, Faiq Hama Saeed Hussain, Giuseppe Zanoni, Giovanni Vidari
People living on the mountains of the Kurdistan Region, Iraq make a large use of herbs in the local traditional medicine. Among them, Tulipa systola, which grows under and between rocks, is very popular as an anti-inflammatory remedy and pain-relief. The phytochemical study of an ethanolic extract obtained from flowers and roots of Tulip (T systola Stapf.) afforded three compounds, identified as (+)-1-O-E-feruloyl-3-O-E-p-coumaroylglycerol (1), (+)-6-tuliposide A (2), and (-)-kaempferol-3-O-rutinoside (3). The significant radical scavenging and antioxidant activity of the isolated compounds were evaluated on three tests, by determining the DPPH free radical scavenging activity, the total antioxidant activity and the hydrogen peroxide scavenging activity...
December 28, 2016: Natural Product Research
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