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peridural dose

Cheng Hui Yang, Tung-Hsin Wu, Chung-Jung Lin, Yi-You Chiou, Ying-Chou Chen, Ming-Huei Sheu, Wan-Yuo Guo, Chen Fen Chiu
PURPOSE: To evaluate the image quality and diagnostic confidence of reduced-dose computed tomography (CT) of the lumbar spine (L-spine) reconstructed with knowledge-based iterative model reconstruction (IMR). MATERIALS AND METHODS: Prospectively, group A consisted of 55 patients imaged with standard acquisition reconstructed with filtered back-projection. Group B consisted of 58 patients imaged with half tube current, reconstructed with hybrid iterative reconstruction (iDose(4)) in Group B1 and knowledge-based IMR in Group B2...
October 2016: European Journal of Radiology
Noriaki Yokogawa, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Miyuki Yamamoto, Shoichi Iseki, Hiroyuki Tsuchiya
PURPOSE: Spinal surgery in a previously irradiated field carries increased risk of perioperative complications, such as delayed wound healing or wound infection. In addition, adhesion around the dura mater is often observed clinically. Therefore, similar to radiation-induced fibrosis--a major late-stage radiation injury in other tissue--epidural fibrosis is anticipated to occur after spinal radiation. In this study, we performed histopathologic assessment of postirradiation changes in the spinal dura mater and peridural tissue in mice...
2015: PloS One
Surachai Sae-Jung, Kitti Jirarattanaphochai
STUDY DESIGN: Experimental study. OBJECTIVE: To evaluate the efficacy and safety of peridural parecoxib-soaked absorbable gelatin sponge, and cellulose membrane on peridural fibrosis prevention in an animal model. SUMMARY OF BACKGROUND DATA: Postoperative peridural fibrosis is one of the causes of failed back surgery syndrome. Nonsteroidal anti-inflammatory drugs inhibit the inflammatory response, while an absorbable gelatin sponge or cellulose membrane interposes between the dura and the paraspinal muscle to staunch the surgical bleeding...
July 15, 2013: Spine
G Giraldi, E De Luca d'Alessandro, A Mannocci, V Vecchione, L Martinoli
OBJECTIVES: Post-operative ileus can also occur in other types of surgery not strictly related to abdomen. The objective of this study was to investigate the efficacy of pantothenic acid administration to stimulate intestinal peristalsis in case of post-operative ileus and estimate the most effective dose. This vitamin can be used for the treatment of chronic atonic intestine or for chronic constipation, but therapeutic indications are not precise in these conditions. PATIENTS AND METHODS: This pilot study has used patients divided in groups treated in post-operative period with physiological solution for patients in control group (Placebo) and Dexpantenolo, which is a derivative in alcohol of pantothenic acid, for all the actively treated patients...
2012: La Clinica Terapeutica
J-L Hanouz, T Simonet, C Marliot, A Mayaud, A Girard, N Rakotnirina, J-L Fellahi, J-L Gérard
OBJECTIVES: The last French survey on alternatives to neuraxial anaesthesia for labour pain was published in 1997. However, intravenous remifentanil has become increasingly used as an option for labour analgesia. We evaluated the use of remifentanil as an alternative to epidural analgesia in level 2 and 3 French maternities in 2009. STUDY DESIGN: This was an internet-based French survey performed in 2009 including all level 2 and 3 maternities. Data recorded were maternity unit characteristic, alternatives to neuraxial analgesia used, and remifentanil administration protocols...
September 2012: Annales Françaises D'anesthèsie et de Rèanimation
Majid Reza Farrokhi, Mohammad Vasei, Saeed Fareghbal, Nasrin Farrokhi
BACKGROUND CONTEXT: Despite progress in surgical techniques, some patients still face postoperative recurrence of pain, although the rate of successful outcomes is estimated to be approximately 70% and 86% after primary decompression spinal surgery. Recently, attention has been focused on peridural fibrosis (PF), which may be responsible for recurrent pain after laminectomy or discectomy. Methylene blue (MB) has been shown to prevent fibrosis formation in various tissues. PURPOSE: The aims of this study were to investigate the effects of MB and assess the effects of different doses on the prevention of postlaminectomy fibrosis formation in a rat model...
February 2011: Spine Journal: Official Journal of the North American Spine Society
Sophie Dupont
The enzyme-inducing antiepileptic drugs such as carbamazepine, phenytoin, barbiturates, oxcarbazepine do not allow oral contraceptives. The pregnancy must be planned. Every patient in childbearing age should be informed by her practitioner. The rule is to optimize the antiepileptic treatment before the pregnancy: less drugs, less dosages. This optimization will depend on the epileptic syndrome and the nature of the treatment. Valproate of sodium should be avoided, if possible, during pregnancy. Preconceptional supplementation by folic acid should be considered...
March 2011: La Presse Médicale
Iwao Sakonju, Kenichi Maeda, Koichi Karasawa, Toshiyuki Tadokoro, Tomoko Kakuta, Katsuaki Takase
The cardiovascular effects of continuous epidural administration (CEA) of lidocaine were investigated in anesthetized dogs. Loading epidural injections of 2, 4, or 6 mg/kg of lidocaine were followed by CEA with 1, 2, or 3 mg/kg/hr lidocaine, respectively, for 2 hr under 2.0% isoflurane anesthesia. Heart rate, direct blood pressure, cardiac index, and stroke volume decreased dose-dependently during CEA, whereas systemic vascular resistance did not significantly differ with dose, and no characteristic changes were observed in any groups...
March 2011: Journal of Veterinary Medical Science
Hakan Emmez, Alp Özgün Börcek, Emre Durdağ, Pınar Göçün Uyar, Memduh Kaymaz, Sükrü Aykol
OBJECTIVE: One of the important causes of failed back surgery is the extensive peridural fibrosis collecting in the surgical field after spinal surgeries. Today we know that inflammatory mechanisms mediated by the immune system of the body plays an important role in generation of fibrosis. Azithromycin, a macrolide antibiotic, has proven immunomodulatory effects in various diseases. This study aims to investigate the effects of azithromycin on peridural fibrosis. METHODS: Twenty-four Wistar rats received laminectomies before dividing them into three groups randomly...
May 2011: Neurological Research
Mark Hartel, Peter Illing, James B Mercer, Jürgen Lademann, Georg Daeschlein, Gerd Hoffmann
Water-filtered infrared-A (wIRA) as a special form of heat radiation with a high tissue penetration and with a low thermal load to the skin surface acts both by thermal and thermic as well as by non-thermal and non-thermic effects. wIRA produces a therapeutically usable field of heat in the tissue and increases tissue temperature, tissue oxygen partial pressure, and tissue perfusion. These three factors are decisive for a sufficient tissue supply with energy and oxygen and consequently as well for wound healing and infection defense...
2007: GMS Krankenhaushygiene Interdisziplinär
Fatih Serhat Erol, Ahmet Kavakli, Necip Ilhan, Ibrahim Hanifi Ozercan, Mustafa Sarsilmaz
AIM: To investigate the effects of melatonin and octreotide in the prevention of peridural fibrosis in an experimental rat model. MATERIAL AND METHODS: A total of 36 rats were divided into three groups: Group I was laminectomized and not given any treatment. Group II received an intraperitoneal 30 microg/kg/day dose of octreotide for six weeks after the laminectomy. Group III rats were injected with melatonin 7.5 mg/kg/day for six weeks after the laminectomy. At the end of six weeks, plasma transforming growth factor beta-1 levels and peridural fibrous tissue hydroxyproline concentrations were determined and histopathological examinations was performed...
January 2010: Turkish Neurosurgery
Márcio Antonio de Souza, João Luiz Pinto e Silva, Nelson Lourenço Maia Filho
PURPOSE: To compare maternal and perinatal results, after the use of continuous peridural versus combined rachidian and peridural analgesia in primiparous parturients. METHODS: Randomized clinical trial with 128 primiparous pregnant women in labor, divided into two groups: peridural analgesia (CPA) with 65 women, and combined continuous rachidian and peridural analgesia (CRPA) with 63, all of them admitted in the pre-labor period at two maternities in Jundiai, in the state of São Paulo...
October 2009: Revista Brasileira de Ginecologia e Obstetrícia
Wei-Ren Su, Jung-Shun Lee, Helen Hai-Wen Chen, Liang-Chao Wang, Yi-Hung Huang, Yun-Chih Jung, I-Ming Jou
STUDY DESIGN: We evaluated the electrophysiological changes to the cauda equina after low-dose external irradiation in a postlaminotomy fibrosis model in rats. OBJECTIVE: To clarify the immediate and long-term electrophysiological responses of antifibrotic radiation therapy in a fibrosis model. SUMMARY OF BACKGROUND DATA: Low-dose perioperative radiation therapy inhibits scar formation. However, its efficacy for preventing fibrosis-induced compressive neuropathy and its potential adverse effect on underlying neural structures have not been studied...
March 1, 2009: Spine
Hakan Emmez, Ozgur Kardes, Fikret Dogulu, Gokhan Kurt, Leyla Memis, M Kemali Baykaner
OBJECTIVE: Extensive peridural fibrosis after spinal surgery may be the underlying cause of failed-back syndrome in some cases. There is increasing evidence that generation of specific cytokine patterns by immune and structural cells and interactions among these cells mediate many of the key events involved in fibrogenesis. Interferon-gamma (IFN-gamma) has several potential antifibrotic actions, including inhibition of fibroblast proliferation and collagen deposition, promotion of fibroblast apoptosis, and inhibition of production and action of the fibrogenic cytokine, transforming growth factor-beta...
June 2008: Neurosurgery
P Nitz, H Laubenthal, S Haller, A Mumme, A Meiser
A 55-year-old patient with severe arterial occlusive disease underwent a femoral artery bypass operation under combined spinal-epidural anaesthesia. Platelet count and coagulation tests were normal after phenprocoumon had been discontinued. The epidural catheter was removed on day 1 while the patient was under therapeutic dose heparin. On day 2 he complained about lower back pain going down both legs and tendon reflexes were absent on the left side. Computed tomography and magnetic resonance imaging showed a lumbar epidural haematoma, which together with a previously existing protrusion of the fourth lumbar disc, compressed the cauda equina...
January 2008: Der Anaesthesist
David C Markel, Todd Doerr, Denis Lincoln, Nora F Bass
Epidural bleeding from spinal anesthetics or epidural catheter placement is concerning, especially when anticoagulants are used. Little is known of the natural changes that occur subdurally or epidurally after each of these procedures. To describe the natural history and occurrence of bleeding that may result from these anesthetics with anticoagulants, we studied 16 joint arthroplasty patients who underwent spinal magnetic resonance imaging postoperatively. Seven patients had an epidural catheter, 7 had a straight spinal injection, and 2 had a general anesthetic...
September 2007: Journal of Arthroplasty
Kitti Jirarattanaphochai, Surachai Jung, Somboon Thienthong, Wimonrat Krisanaprakornkit, Chat Sumananont
STUDY DESIGN: A randomized, double-blind placebo controlled trial in multimodal analgesia for postoperative pain was conducted. OBJECTIVE: To examine whether combination of corticosteroid and bupivacaine administered in patients undergoing posterior lumbosacral spine surgery reduces postoperative morphine consumption, back and leg pain relief, and improves functional disability and general health status. SUMMARY OF BACKGROUND DATA: Patients with lumbar spine surgery had moderate to severe postoperative pain...
March 15, 2007: Spine
Mona Momeni, Manuela Crucitti, Marc De Kock
Patient-controlled analgesia (PCA) is a delivery system with which patients self-administer predetermined doses of analgesic medication to relieve their pain. Since its introduction in the early 1980s, the daily management of postoperative pain has been extensively optimised. The use of PCA in hospitals has been increasing because of its proven advantages over conventional intramuscular injections. These include improved pain relief, greater patient satisfaction, less sedation and fewer postoperative complications...
2006: Drugs
Claude Lejeune, Laurence Simmat-Durand, Laurent Gourarier, Sandrine Aubisson et al.
Specialized prenatal care and substitution programs improve the perinatal prognoses of pregnant drug-abusers and their infants. Although methadone is well documented, little is known about high-dose buprenorphine (HDB). This prospective, multicenter (n = 35) observational study included 259 women on maintenance during pregnancy: 39% on methadone and 61% on HDB. Major findings were: 46% of them received good prenatal care; 62% had peridural analgesia; 12.3% delivered prematurely (<37 weeks); mean gestational age, 38...
May 20, 2006: Drug and Alcohol Dependence
B Aurilio, M C Pace, M B Passavanti
of this study was to evaluate the effectiveness and the safety of the association of buprenorphine transdermal delivery system (TDS) (Transtec TDS) and peridural infusion of morphine and naropine, for the control of ischemic pain in patients suffering from peripheral arteriopathy. The administration of an opioid, pure agonist, as morphine, with a partial agonist opioid, as the buprenorphine, was used. Buprenorphine has shown a higher liposolubility in supraspinal districts, while the morphine acts above all on the mu receptor subtype of the spinal cord...
July 2005: Minerva Anestesiologica
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