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neonatal ABO incompatibility

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https://www.readbyqxmd.com/read/27878783/prediction-of-significant-hyperbilirubinemia-in-term-neonates-by-early-non-invasive-bilirubin-measurement
#1
Manish Jain, Akash Bang, Anju Tiwari, Shuchi Jain
BACKGROUND: Neonatal jaundice is a common problem. We evaluated the utility and best cut-off values of 24-and 48-hour transcutaneous bilirubin indices (TcBI) in predicting subsequent significant hyperbilirubinemia and evaluated various associated maternal and fetal risk factors. METHODS: TcBI at 24 and 48 hours and serum bilirubin levels at 72 hours of age were obtained for healthy, term, appropriate for gestational age neonates. Neonates with prematurity, birth weight <2500 g, ABO or Rh incompatibility, onset of clinical jaundice <24 hours, clinical suspicion of septicemia, positive pressure ventilation at birth, admission in neonatal intensive care unit and contraindications for BiliChek were excluded...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27842454/the-role-of-ugt1a1-promoter-polymorphism-and-exon-1-mutations-in-neonatal-jaundice
#2
Hülya Halis, Hacer Ergin, Aylin Köseler, Erol Ömer Atalay
OBJECTIVE: In the present study we investigated the effects of promoter polymorphism and an exon-1 mutation (G71R) in the UGT1A1 gene in neonates with unexplained hyperbilirubinemia and direct coombs-negative [DC(-)] ABO incompatibility. METHODS: Two hundred term neonates in their first week of life and without additional icterogenic factors were included in the study. Neonates with a serum total bilirubin (STB) level≥17 mg/dL constituted the hyperbilirubinemia group (n = 100) while the control group comprised healthy neonates with a STB level < 12...
November 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27557546/risk-assessment-of-gene-variants-for-neonatal-hyperbilirubinemia-in-taiwan
#3
Yi-Hao Weng, Ya-Wen Chiu, Shao-Wen Cheng, Chun-Yuh Yang
BACKGROUND: Hyperbilirubinemia is a common disorder during neonatal period in Taiwan. Gene variants may play an important role in the development of neonatal hyperbilirubinemia. The current study investigated the association between neonatal hyperbilirubinemia and common gene variants involving the production and metabolism of bilirubin. METHODS: This prospective study enrolled 444 healthy infants born in the Chang Gung Memorial Hospital at Taipei from 2013-2015...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27398328/hyperbilirubinemia-in-neonates-types-causes-clinical-examinations-preventive-measures-and-treatments-a-narrative-review-article
#4
REVIEW
Sana Ullah, Khaista Rahman, Mehdi Hedayati
BACKGROUND: Hyperbilirubinemia, or jaundice, is a life threatening disorder in newborns. It is a multifactorial disorder with many symptoms. Generally, the physiological jaundice is the most prevalent type however in some regions pathological jaundice is also common. This review article focuses on a brief introduction to jaundice, its types and causes, measuring the bilirubin level, clinical approaches towards hyperbilirubinemia, different precautionary measures for the parents of babies suffering from hyperbilirubinemia and different remedial therapeutic measures for its treatment...
May 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27382636/exchange-transfusion-for-neonatal-hyperbilirubinemia-in-johannesburg-south-africa-from-2006-to-2011
#5
Daynia E Ballot, Gilbert Rugamba
Background. Severe hyperbilirubinaemia requiring exchange transfusion has become less common in recent years; however, kernicterus still occurs. The aim of this study was to review babies undergoing exchange transfusion for severe hyperbilirubinaemia in a Johannesburg hospital. Methodology. This was a retrospective review of babies who required exchange transfusion in both the neonatal and the paediatric wards from June 1, 2006, to December 31, 2011. Results. There were 64 patients who underwent 67 exchange transfusions...
2016: International Scholarly Research Notices
https://www.readbyqxmd.com/read/27275310/evaluation-of-neonatal-hemolytic-jaundice-clinical-and-laboratory-parameters
#6
Anet Papazovska Cherepnalkovski, Vjekoslav Krzelj, Beti Zafirovska-Ivanovska, Todor Gruev, Josko Markic, Natasa Aluloska, Nikolina Zdraveska, Katica Piperkovska
BACKGROUND: Neonatal jaundice that occurs in ABO or Rhesus issoimunisation has been recognized as one of the major risk factors for development of severe hyperbilirubinemia and bilirubin neurotoxicity. AIM: Aim of our study was to investigate clinical and laboratory parameters associated with hemolytic jaundice due to Rh and ABO incompatibility and compare results with the group of unspecific jaundice. MATERIAL AND METHODS: One hundred sixty seven (167) neonatal hyperbilirubinemia cases were included in the study, 24...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27065585/exchange-transfusion-for-severe-neonatal-hyperbilirubinemia-17%C3%A2-years-experience-from-vojvodina-serbia
#7
Nevenka Bujandric, Jasmina Grujic
This study aimed to evaluate the frequency of the main risk factors for severe neonatal hyperbilirubinemia, to determine the incidence of exchange transfusion (ET) in the Autonomous Province of Vojvodina (the northern part of Serbia) and to describe the experience with ET performed in premature and term infants during the past 17 years. We performed a retrospective data analysis of 398 newborn infants who underwent a double volume ET from 1997 to 2013. During the 17 year study period, a decreasing incidence of ET, expressed per thousand newborns, was observed...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27057339/risk-factors-for-acute-bilirubin-encephalopathy-on-admission-to-two-myanmar-national-paediatric-hospitals
#8
G Arnolda, H M Nwe, D Trevisanuto, A A Thin, A A Thein, T Defechereux, D Kumara, L Moccia
BACKGROUND: Jaundice is the commonest neonatal ailment requiring treatment. Untreated, it can lead to acute bilirubin encephalopathy (ABE), chronic bilirubin encephalopathy (CBE) or death. ABE and CBE have been largely eliminated in industrialised countries, but remain a problem of largely undocumented scale in low resource settings. As part of a quality-improvement intervention in the Neonatal Care Units of two paediatric referral hospitals in Myanmar, hospitals collected de-identified data on each neonate treated on new phototherapy machines over 13-20 months...
2015: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/27003893/heliotherapy-for-neonatal-hyperbilirubinemia-in-southwest-nigeria-a-baseline-pre-intervention-study
#9
Abieyuwa A Emokpae, Cecilia A Mabogunje, Zainab O Imam, Bolajoko O Olusanya
BACKGROUND: A novel filtered-sunlight phototherapy (FSPT) device has been demonstrated to be safe and efficacious for treating infants with neonatal jaundice in resource-constrained tropical settings. We set out to provide baseline data for evaluating the clinical impact of this device in a referral pediatric hospital. METHODS: We reviewed the medical records of infants admitted for neonatal hyperbilirubinemia in an inner-city Children's Hospital in Lagos, between January 2012 and December 2014 to determine the pattern, treatment and outcomes during the pre-intervention period...
2016: PloS One
https://www.readbyqxmd.com/read/26866975/prevalence-of-glucose-6-phosphate-dehydrogenase-deficiency-in-jaundiced-egyptian-neonates
#10
Wafaa Moustafa M Abo El Fotoh, Mohammed Soliman Rizk
BACKGROUND: The enzyme, Glucose-6-phosphate dehydrogenase (G6PD), deficiency leads to impaired production of reduced glutathione and predisposes the red cells to be damaged by oxidative metabolites, causing hemolysis. Deficient neonates may manifest clinically as hyperbilirubinemia or even kernicterus. OBJECTIVE: This study was carried out to detect erythrocyte G6PD deficiency in neonatal hyperbilirubinemia. METHODS AND DESIGN: To determine the frequency and effect of G6PD deficiency, this study was conducted on 202 neonates with indirect hyperbilirubinemia...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26852177/severe-neonatal-hyperbilirubinemia-decreased-after-the-2007-canadian-guidelines
#11
Michael Sgro, Sharmilaa Kandasamy, Vibhuti Shah, Marianna Ofner, Douglas Campbell
OBJECTIVES: To estimate the incidence of severe neonatal hyperbilirubinemia in Canada from 2011-2013 following the implementation of the Canadian Pediatric Society's published guidelines on the management of hyperbilirubinemia in 2007. Our previously reported incidence of hyperbilirubinemia in Canada was 1 in 2480. STUDY DESIGN: Term infants ≤ 60 days of age, with a peak serum total bilirubin level > 425 μmol/L or who had an exchange transfusion were followed prospectively through the Canadian Pediatric Surveillance Program from 2011-2013...
April 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26841084/indication-of-mild-hemolytic-reaction-among-preterm-infants-with-abo-incompatibility
#12
Maya Yogev-Lifshitz, Leah Leibovitch, Irit Schushan-Eisen, Camelia Taran, Tzipora Strauss, Ayala Maayan-Metzger
BACKGROUND: Among term infants, ABO incompatibility is a leading cause of hemolytic disease and neonatal jaundice. With respect to preterm infants, data are lacking. OBJECTIVE: To evaluate the incidence and severity of ABO incompatibility hemolytic disease among preterm infants with respect to hemolytic and jaundice parameters. DESIGN: Clinical and laboratory data were collected retrospectively from the medical records of 118 ABO-incompatible preterms born at gestational age (GA) 29-34 weeks, as well as 118 controls matched for GA, birth weight, and multiplicity...
June 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26808624/predictors-of-repeat-exchange-transfusion-for-severe-neonatal-hyperbilirubinemia
#13
Cecilia A Mabogunje, Abieyuwa A Emokpae, Bolajoko O Olusanya
OBJECTIVES: To identify the predictors of repeat exchange transfusion among infants with severe hyperbilirubinemia. DESIGN: Retrospective cross-sectional study. SETTING: A referral children's hospital in inner-city Lagos, Nigeria. PATIENTS: Infants who received exchange transfusion for severe hyperbilirubinemia from January 2012 to December 2014. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: The predictors of repeat exchange transfusion were identified among all infants who had at least one exchange transfusion using multivariable logistic regression...
March 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26782094/post-test-probability-for-neonatal-hyperbilirubinemia-based-on-umbilical-cord-blood-bilirubin-direct-antiglobulin-test-and-abo-compatibility-results
#14
Bart Peeters, Inge Geerts, Mia Van Mullem, Isabel Micalessi, Veroniek Saegeman, Jan Moerman
UNLABELLED: Many hospitals opt for early postnatal discharge of newborns with a potential risk of readmission for neonatal hyperbilirubinemia. Assays/algorithms with the possibility to improve prediction of significant neonatal hyperbilirubinemia are needed to optimize screening protocols and safe discharge of neonates. This study investigated the predictive value of umbilical cord blood (UCB) testing for significant hyperbilirubinemia. Neonatal UCB bilirubin, UCB direct antiglobulin test (DAT), and blood group were determined, as well as the maternal blood group and the red blood cell antibody status...
May 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/26755212/the-burden-and-management-of-neonatal-jaundice-in-nigeria-a-scoping-review-of-the-literature
#15
B O Olusanya, F B Osibanjo, C A Mabogunje, T M Slusher, S A Olowe
Neonatal jaundice is a leading cause of hospitalization in the first week of life worldwide. If inappropriately managed, it may result in significant bilirubin-induced mortality and disability. We set out to describe the epidemiology of neonatal hyperbilirubinemia as well as the practices and challenges in the care of infants with significant neonatal hyperbilirubinemia (SNH) in Nigeria, as basis for policy intervention and research priorities. We systematically searched PubMed, Scopus, EMBASE, Cumulative Index to Nursing and Allied Health Literature, WHO Library Database, African Index Medicus, African Journals Online, and local journals for studies published between January 1960 and December 2014...
January 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/26643826/a-prospective-study-on-exchange-transfusion-in-neonatal-unconjugated-hyperbilirubinemia-in-a-tertiary-care-hospital-nepal
#16
T Malla, S Singh, P Poudyal, B Sathian, G Bk, K K Malla
BACKGROUND: An exchange transfusion involves replacing patient's blood with donor blood in order to remove abnormal blood components and circulating toxins while maintaining adequate circulating blood volume. OBJECTIVE: To observe the incidence, causes of jaundice requiring Exchange and any adverse event of exchange transfusion in newborns with unconjugated hyperbilirubinemia. METHOD: Prospective study undertaken at Neonatal Intensive Care Unit (NICU) of Manipal Teaching Hospital, Pokhara, Nepal from March 2014 to April 2015...
April 2015: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/26626422/neonatal-tolerance-applicability-to-solid-organ-transplantation
#17
REVIEW
Lori J West
PURPOSE OF REVIEW: The phenomenon of tolerance induced during immunologic immaturity has been explored for more than 60 years. Although direct application of neonatal tolerance to organ transplantation in human newborns is limited, exploiting discrete components of neonatal immaturity is proving fruitful. RECENT FINDINGS: Two reviews comprehensively considered features and impact of neonatal tolerance as described in the 1950s. Recent imaging studies in mice demonstrated complex functional interactions especially of donor regulatory T cells with emerging neonatal immune components...
February 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/26477873/prospective-surveillance-of-extreme-neonatal-hyperbilirubinemia-in-australia
#18
Angela McGillivray, Jan Polverino, Nadia Badawi, Nick Evans
OBJECTIVES: To determine the incidence, causes, associated factors, and short-term outcomes of extreme neonatal hyperbilirubinemia in Australia in order to identify opportunities for prevention. STUDY DESIGN: This was a prospective population-based surveillance study in collaboration with the Australian Pediatric Surveillance Unit between April 1, 2010, and March 31, 2013. Case definition was: infants >34 weeks gestation with a peak total serum bilirubin ≥450 μmol/L and or clinical evidence of bilirubin encephalopathy...
January 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26454433/infants-at-risk-of-significant-hyperbilirubinemia-in-poorly-resourced-countries-evidence-from-a-scoping-review
#19
REVIEW
Bolajoko O Olusanya, Tina M Slusher
BACKGROUND: Neonatal hyperbilirubinemia is frequently associated with disproportionately high rates of bilirubin-induced mortality and long-term morbidities in low- and middle-income countries (LMICs). This scoping review aimed to identify possible etiological/risk factors for clinically significant hyperbilirubinemia in LMICs so as to guide intervention and future research priorities. DATA SOURCES: We systematically searched PubMed, Scopus, Excerpt Medica Database, Cumulative Index to Nursing and Allied Health Literature, WHO Library Database, African Index Medicus, African Journals Online, Latin American and Caribbean Health Sciences Literature, and Indian Medical Journals for reports published between January 1990 and August 2014 in LMICs with per capita income of ≤ US$ 6000...
November 2015: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/26422285/neonatal-bo-incompatibility-is-associated-with-a-positive-cord-blood-direct-antiglobulin-test-in-infants-of-black-ethnicity
#20
Bülent Özgönenel, Geetika Kukreja, Barbara O'Malley, Martin H Bluth
ABO hemolytic disease of the newborn occurs almost exclusively in infants of blood group A and B who are born to group O mothers. Positive Direct Antiglobulin Test (DAT) can identify those infants who are at risk of developing the ABO hemolytic disease. Earlier studies have suggested that BO incompatibility is associated with a positive DAT in black infants. In this study we sought to determine whether ABO incompatibility type could be associated with a higher rate of DAT positivity or clinical hemolytic disease...
November 2015: Journal of Pediatric Hematology/oncology
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