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neonatal ABO incompatibility

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https://www.readbyqxmd.com/read/30298137/identification-of-genetic-risk-factors-for-neonatal-hyperbilirubinemia-in-fujian-province-southeastern-china-a-case-control-study
#1
Jinfu Zhou, Changyi Yang, Wenbin Zhu, Shuwei Chen, Yinglin Zeng, Jing Wang, Hong Zhao, Yao Chen, Feng Lin
To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A total of 286 hyperbilirubinemic newborns were enrolled as a case group, and 250 randomly selected newborns without jaundice or with a bilirubin level that was lower than the threshold required for phototherapy served as controls. The serum levels of total bilirubin, unconjugated bilirubin, and direct bilirubin were measured, and the common genetic loci in UGT1A1, OATP1B1, and HO-1 genes were genotyped...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30089533/association-between-rooming-in-policy-and-neonatal-hyperbilirubinemia
#2
Ken-Hsyuan Shan, Teh-Ming Wang, Ming-Chih Lin
BACKGROUND: The practices promoted by the Baby-friendly Hospital Initiative have become a part of current mainstream postpartum infant care. Rooming-in to facilitate skin-to-skin contact and breastfeeding is a major component of this initiative. However, whether rooming-in is associated with admission for neonatal hyperbilirubinemia has seldom been reported. The aim of this study was to evaluate the association between rooming-in and neonatal hyperbilirubinemia. METHODS: This was a retrospective cohort study...
June 12, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/30044350/severe-abo-hemolytic-disease-of-the-newborn-requiring-exchange-transfusion
#3
Ryan A Metcalf, Jenna Khan, Jennifer Andrews, Dennis Mayock, Zeenia Billimoria, Monica B Pagano
ABO incompatibility (ABOi), the most common cause of hemolytic disease of the newborn (HDN), is nearly always mild and treatable with phototherapy. Reports of ABOi HDN requiring neonatal exchange transfusion are extremely rare since the inception of modern guidelines. Here, a case of ABOi HDN clearly met criteria for exchange transfusion. An O-positive African American mother delivered a B-positive neonate that quickly developed hyperbilirubinemia. The neonatal DAT was positive from anti-B and anti-A,B, and maternal IgG titer was 1024...
July 23, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30011398/elimination-of-abo-blood-group-incompatible-fetal-red-blood-cells-in-the-maternal-circulation-relevance-to-the-diagnosis-of-fetal-maternal-hemorrhage
#4
Mutaz Dana, Eitan Fibach
BACKGROUND: Fetal-maternal hemorrhage (FMH) occurs when fetal red blood cells (RBC) pass into the maternal circulation as a result of obstetric- or trauma-related complications to pregnancy. Their detection in the maternal blood is commonly used as a diagnostic test. There is, however, a serious and general limitation to this test that is sometimes ignored. Fetal RBC carrying the father's antigens (most crucially, the ABO blood antigens) may be incompatible with the mother's plasma. They are expected to be eliminated by the maternal natural antibodies, thus, negative results may be false...
2018: Neonatology
https://www.readbyqxmd.com/read/29935542/clinical-evaluation-of-severe-neonatal-hyperbilirubinaemia-in-a-resource-limited-setting-a-4-year-longitudinal-study-in-south-east-nigeria
#5
Chidiebere D I Osuorah, Uchenna Ekwochi, Isaac N Asinobi
BACKGROUND: Neonatal hyperbilirubinaemia is one of the commonest causes of hospital visit in the neonatal period. When severe, it is a leading cause of irreversible neurological and musculoskeletal disability. Prompt recognition and timely interventions are imperative for a drastic reduction in complications associated with severe hyperbilirubinaemia in newborns. METHODS: We report a 4-year descriptive and longitudinal study to determine the causes, clinical presentations and long-term outcomes in newborns admitted for severe neonatal jaundice...
June 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29895274/indirect-neonatal-hyperbilirubinemia-in-hospitalized-neonates-on-the-thai-myanmar-border-a-review-of-neonatal-medical-records-from-2009-to-2014
#6
L Thielemans, M Trip-Hoving, J Landier, C Turner, T J Prins, E M N Wouda, B Hanboonkunupakarn, C Po, C Beau, M Mu, T Hannay, F Nosten, B Van Overmeire, R McGready, V I Carrara
BACKGROUND: Indirect neonatal hyperbilirubinemia (INH) is a common neonatal disorder worldwide which can remain benign if prompt management is available. However there is a higher morbidity and mortality risk in settings with limited access to diagnosis and care. The manuscript describes the characteristics of neonates with INH, the burden of severe INH and identifies factors associated with severity in a resource-constrained setting. METHODS: We conducted a retrospective evaluation of anonymized records of neonates hospitalized on the Thai-Myanmar border...
June 12, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29809326/-bronze-baby-syndrome-an-unpredictable-complication-of-phototherapy-a-case-report
#7
Juan Sebastián Peinado-Acevedo, Estephanía Chacón-Valenzuela, Laura Liliana Rodríguez-Moncada
The bronze baby syndrome is an infrequent dyschromia resulting from phototherapy in newborn babies with neonatal jaundice. Even though the common phenotype has been described in patients with direct neonatal hyperbilirubinemia secondary to cholestasis, several cases of patients with indirect neonatal hyperbilirubinemia who have managed to reverse it have been reported, as well as patients with isolated hyperbilirubinemia.Currently, the physiopathology of this condition is still a subject of controversy and, therefore, there is a lack of clear conducts for its correct diagnosis and treatment...
May 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29802103/learning-from-claims-hyperbilirubinaemia-and-kernicterus
#8
Janet M Rennie, Jeanette Beer, Michele Upton
We examined claims made against the National Health Service (NHS) involving neonatal jaundice in order to determine whether there were lessons that could be learnt from common themes.This was a retrospective anonymised study using information from the NHS Resolution database for 2001-2011.Twenty cases (16 males) had sufficient information for analysis. Fifteen had confirmed cerebral palsy and two young children had damage to the globus pallidus without confirmed CP. In three cases, the outcome was uncertain...
May 25, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29686715/knowledge-level-and-determinants-of-neonatal-jaundice-a-cross-sectional-study-in-the-effutu-municipality-of-ghana
#9
Prince Adoba, Richard K D Ephraim, Kate Adomakowaah Kontor, Joseph-Josiah Bentsil, Patrick Adu, Maxwell Anderson, Samuel Asamoah Sakyi, Paul Nsiah
Background: Neonatal jaundice (NNJ) is a major cause of hospital admission during the neonatal period and is associated with significant mortality. This case-control study with cross-sectional design sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition. Methods: One hundred and fifty (150) neonates comprising 100 with clinically evident jaundice and 50 without jaundice were conveniently recruited from the Trauma and Specialist Hospital in the Effutu Municipality...
2018: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29560141/maternal-fetal-rhesus-rh-factor-incompatibility-in-arar-northern-saudi-arabia
#10
Raghad Mubarak Aljuhaysh, Nagah Mohamed Abo El-Fetoh, Malak Ibrahim Alanazi, Afaf Shuaib Albaqawi, Wafa Mohammed Alanazi, Najah Salah Alanazi, Reham Muqbil Alanazi, Atheer Mutab Alanazi, Eiman Mohammad Alnemer, Rahma Abdulhadi Alenezi, Tasleem Khoudier Alabdullatif, Rehab Abdallah Alanazi, Samiyah Sarhan Alanazi, Kawthar Saeed Alsultan, Ibtisam Matan Alanazi, Duaa Sami Alsunayni
Background and aim: Rh isoimmunization still contributes to the neonatal morbidity and mortality due to non-immunization, under-immunization, and in rare cases, false Rh typing. The main objective of this study was to determine the prevalence of Rh incompatibility, mothers' knowledge about Rh incompatibility, mothers' knowledge about anti-D immunoglobulin and to show the pregnancy outcome of Rh negative mothers. Methods: A cross-sectional study was carried out at the Maternity and Children Hospital in Arar city from November 2016 to May 2017...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29551014/immunoglobulin-for-alloimmune-hemolytic-disease-in-neonates
#11
REVIEW
Carolien Zwiers, Mirjam Ea Scheffer-Rath, Enrico Lopriore, Masja de Haas, Helen G Liley
BACKGROUND: Exchange transfusion and phototherapy have traditionally been used to treat jaundice and avoid the associated neurological complications. Because of the risks and burdens of exchange transfusion, intravenous immunoglobulin (IVIg) has been suggested as an alternative therapy for alloimmune hemolytic disease of the newborn (HDN) to reduce the need for exchange transfusion. OBJECTIVES: To assess the effect and complications of IVIg in newborn infants with alloimmune HDN on the need for and number of exchange transfusions...
March 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29492389/neonatal-heart-transplantation
#12
Mohan John, Leonard L Bailey
Neonatal heart transplantation was developed and established in the 1980's as a durable modality of therapy for complex-uncorrectable heart disease. Patients transplanted in the neonatal period have experienced unparalleled long-term survival, better than for any other form of solid-organ transplantation. However, the limited availability of neonatal and young infant donors has restricted the indications and applicability of heart transplantation among newborns in the current era. Indications for heart transplantation include congenital heart disease not amenable to other forms of surgical palliation, and cardiomyopathy, including some primary tumors...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28931391/umbilical-cord-bilirubin-as-a-predictor-of-neonatal-jaundice-a-retrospective-cohort-study
#13
Kelsey D J Jones, S E Grossman, Dharshini Kumaranayakam, Arati Rao, Greg Fegan, Narendra Aladangady
BACKGROUND: Hyperbilirubinaemia is a major cause of neonatal morbidity. Early identification of those infants most at risk might allow the development of targeted primary preventative therapy and follow-up. The objective of this study was to assess whether arterial umbilical cord bilirubin (aUCB) level at delivery predicts the development of neonatal jaundice in term deliveries. METHODS: Retrospective analysis of hospital biochemistry records identified term deliveries with recorded aUCB...
September 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28719639/oral-administration-of-chinese-herbal-medicine-during-gestation-period-for-preventing-hemolytic-disease-of-the-newborn-due-to-abo-incompatibility-a-systematic-review-of-randomized-controlled-trials
#14
REVIEW
Huijuan Cao, Ruohan Wu, Mei Han, Patrina Ha Yuen Caldwell, Jian-Ping Liu
BACKGROUND: About 85.3% of hemolytic disease of the newborn (HDN) is caused by maternal-fetal ABO blood group incompatibility. However, there is currently no recommended "best" therapy for ABO incompatibility during pregnancy. OBJECTIVES: To systematically assess the safety and effectiveness of oral Chinese herbal medicine (CHM) for preventing HDN due to ABO incompatibility. METHODS: The protocol of this review was registered on the PROSPERO website (No...
2017: PloS One
https://www.readbyqxmd.com/read/28662083/report-about-term-infants-with-severe-hyperbilirubinemia-undergoing-exchange-transfusion-in-southwestern-china-during-an-11-year-period-from-2001-to-2011
#15
Canfeng Yu, Huifan Li, Qiannan Zhang, Huayun He, Xinhong Chen, Ziyu Hua
OBJECTIVES: This study was intended to explore the etiology and risk factors of severe neonatal hyperbilirubinemia and to analyze the adverse events associated with ECT (Exchange Transfusion), as well as to identify the factors related to the poor prognosis. METHODS: All of the full-term neonates who had undergone ECT for hyperbilirubinemia at Children's Hospital of Chongqing Medical University from January 2001 to December 2011 were enrolled in this study. General demographic characteristics, comorbidities, pre- and post-exchange TSB(Total Serum Bilirubin) levels, duration and frequency of ECT, and clinical outcomes were recorded and analyzed anonymously...
2017: PloS One
https://www.readbyqxmd.com/read/28079409/promoting-awareness-of-neonatal-menstruation
#16
REVIEW
Paola Bianchi, Giuseppe Benagiano, Ivo Brosens
Neonatal uterine bleeding (NUB) has been carefully studied in the past through case reports, small series, clinical cohort studies, pathology investigations of fetal and neonatal. Following a historical recount, this review summarizes biological mechanisms conditioning NUB, starting from the persistence till birth of an 'ontogenetic progesterone resistance' (OPR), causing decreased responsiveness of target tissues to bioavailable progesterone. Several pregnancy-related conditions, such as preeclampsia, fetal growth restriction, prematurity, post-maturity and even Rhesus or ABO incompatibility, influence the occurrence of NUB...
March 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28036100/haemolytic-and-nonhaemolytic-jaundice-revisited
#17
LETTER
Michael Kaplan
No abstract text is available yet for this article.
April 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27878783/prediction-of-significant-hyperbilirubinemia-in-term-neonates-by-early-non-invasive-bilirubin-measurement
#18
Manish Jain, Akash Bang, Anju Tiwari, Shuchi Jain
BACKGROUND: Neonatal jaundice is a common problem. We evaluated the utility and best cut-off values of 24-and 48-hour transcutaneous bilirubin indices (TcBI) in predicting subsequent significant hyperbilirubinemia and evaluated various associated maternal and fetal risk factors. METHODS: TcBI at 24 and 48 hours and serum bilirubin levels at 72 hours of age were obtained for healthy, term, appropriate for gestational age neonates. Neonates with prematurity, birth weight <2500 g, ABO or Rh incompatibility, onset of clinical jaundice <24 hours, clinical suspicion of septicemia, positive pressure ventilation at birth, admission in neonatal intensive care unit and contraindications for BiliChek were excluded...
June 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27842454/the-role-of-ugt1a1-promoter-polymorphism-and-exon-1-mutations-in-neonatal-jaundice
#19
Hülya Halis, Hacer Ergin, Aylin Köseler, Erol Ömer Atalay
OBJECTIVE: In the present study, we investigated the effects of promoter polymorphism and an exon-1 mutation (G71R) in the UGT1A1 gene in neonates with unexplained hyperbilirubinemia and direct Coombs-negative [DC(-)] ABO incompatibility. METHODS: Two-hundred term neonates in their first week of life and without additional icterogenic factors were included in the study. Neonates with a serum total bilirubin (STB) level ≥17 mg/dL constituted the hyperbilirubinemia group (n = 100), while the control group comprised healthy neonates with a STB level <12...
November 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27557546/risk-assessment-of-gene-variants-for-neonatal-hyperbilirubinemia-in-taiwan
#20
Yi-Hao Weng, Ya-Wen Chiu, Shao-Wen Cheng, Chun-Yuh Yang
BACKGROUND: Hyperbilirubinemia is a common disorder during neonatal period in Taiwan. Gene variants may play an important role in the development of neonatal hyperbilirubinemia. The current study investigated the association between neonatal hyperbilirubinemia and common gene variants involving the production and metabolism of bilirubin. METHODS: This prospective study enrolled 444 healthy infants born in the Chang Gung Memorial Hospital at Taipei from 2013-2015...
August 24, 2016: BMC Pediatrics
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