keyword
https://read.qxmd.com/read/35747579/predicting-significant-hyperbilirubinemia-in-abo-incompatibility-is-cord-direct-antiglobulin-test-useful
#21
JOURNAL ARTICLE
Sphurti Chowdhary, Usha Devi, Sethuraman Giridhar
To study the prevalence of direct antiglobulin test (DAT) positivity and outcomes in babies with ABO incompatibility and the role of DAT in predicting need for phototherapy. This was an analytical retrospective cohort study conducted in a tertiary care hospital in South India. DAT was performed routinely in cord blood of all neonates born to O positive mothers. The case records of neonates ≥ 35 weeks of gestation and birth weight > 2000 gm with ABO setting born between January 2019 and December 2020 were reviewed and outcomes were analyzed...
July 2022: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/35700699/risk-factors-predicting-the-need-for-phototherapy-in-glucose-6-phosphate-dehydrogenase-deficient-infants-in-a-large-retrospective-cohort-study
#22
JOURNAL ARTICLE
Krishna Revanna Gopagondanahalli, Rashmi Arun Mittal, Abdul Alim Abdul Haium, Bin Huey Quek, Pratibha Agarwal, Lourdes Mary Daniel, Mei Chien Chua, Victor Samuel Rajadurai
INTRODUCTION: Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of severe neonatal hyperbilirubinemia. This study evaluates the risk factors predicting the need for phototherapy in G6PD-deficient neonates after 72 h of age and assesses the safety of early discharge. METHODS: A retrospective cohort study of 681 full-term G6PD-deficient infants with a birth weight ≥2,500 g over 4 years was conducted. We compared the baseline characteristics, bilirubin level on day 4 (after 72 h of life), day of peak bilirubin, G6PD levels, and concomitant ABO incompatibility between the group that required phototherapy (Group A) and those who did not (Group B)...
2022: Neonatology
https://read.qxmd.com/read/35573949/intravenous-immunoglobulin-use-in-hemolytic-disease-due-to-abo-incompatibility-to-prevent-exchange-transfusion
#23
JOURNAL ARTICLE
Emel Okulu, Omer Erdeve, Ilknur Kilic, Ozgur Olukman, Sebnem Calkavur, Gokhan Buyukkale, Merih Cetinkaya, Dilek Ulubas, Nihal Demirel, Deniz Hanta, Sabahattin Ertugrul, Nazli Dilay Gultekin, Oguz Tuncer, Nihat Demir, Leyla Bilgin, Nejat Narli, Duran Yildiz, Demet Terek, Ozge Altun Koroglu, Canan Seren, Elif Ozyazici, Ramazan Ozdemir, Hatice Turgut, Fatma Narter, Yasemin Akin, Ahmet Ozyazici, Aysegul Zenciroglu, Huseyin Selim Asker, Zeynel Gokmen, Musa Salihli, Ali Bulbul, Umut Zubarioglu, Begum Atasay, Esin Koc
INTRODUCTION: Intravenous immunoglobulin (IVIG) has been widely used to treat the hemolytic disease of the newborn (HDN). Although it has been shown that IVIG treatment reduces the duration of phototherapy and hospitalization, the use of IVIG in hemolytic disease due to ABO incompatibility has been controversial in recent years. This study aimed to investigate the role of IVIG in the prevention of exchange transfusion in infants with ABO HDN who presented with bilirubin levels at or above the level of exchange transfusion...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35091450/severe-neonatal-hyperbilirubinaemia-lessons-learnt-from-a-national-perinatal-audit
#24
JOURNAL ARTICLE
Berthe A M van der Geest, Ageeth N Rosman, Klasien A Bergman, Bert J Smit, Peter H Dijk, Jasper V Been, Christian V Hulzebos
OBJECTIVES: To describe characteristics of neonates with severe neonatal hyperbilirubinaemia (SNH) and to gain more insight in improvable factors that may have contributed to the development of SNH. DESIGN AND SETTING: Descriptive study, based on national Dutch perinatal audit data on SNH from 2017 to 2019. PATIENTS: Neonates, born ≥35 weeks of gestation and without antenatally known severe blood group incompatibility, who developed hyperbilirubinaemia above the exchange transfusion threshold...
September 2022: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/34847590/positive-direct-antiglobulin-test-is-it-a-risk-factor-for-significant-hyperbilirubinemia-in-neonates-with-abo-incompatibility
#25
JOURNAL ARTICLE
Secil Ercin, Yesim Coskun, Kalender Kayas, Nazan Kavas, Tugba Gursoy
OBJECTIVE:  ABO blood group (ABO) incompatibility is a common cause of neonatal indirect hyperbilirubinemia. The direct antiglobulin test (DAT) can identify infants developing hemolytic disease. This study aims to evaluate the significance of DAT positivity among neonates with ABO incompatibility. STUDY DESIGN:  This retrospective study included 820 neonates with blood group A or B who were born to blood group O mothers. The study group consisted of neonates ( n  = 79) who had positive DAT, and the control group consisted of infants ( n  = 741) who had negative DAT...
November 30, 2021: American Journal of Perinatology
https://read.qxmd.com/read/34513509/the-spectrum-of-hemolytic-disease-of-the-newborn-evaluating-the-etiology-of-unconjugated-hyperbilirubinemia-among-neonates-pertinent-to-immunohematological-workup
#26
JOURNAL ARTICLE
Suman S Routray, Rachita Behera, Bhabagrahi Mallick, Devi Acharya, Jagdish P Sahoo, Girija N Kanungo, Bibudhendu Pati
Background and objective The exact burden of hemolytic disease of the newborn (HDN) attributed to neonatal unconjugated hyperbilirubinemia (NUH) in developing nations is still unclear. Still, anti-D is reported to be the most common cause of HDN in India. ABO incompatibility has emerged as a leading cause of exchange transfusion (ET) in many countries. But many centers in our country rely on direct antiglobulin test (DAT) as a screening tool to evaluate immunological causes, whereas advanced immunohematological workup like antibody screening, identification, and elution tests are also required...
August 2021: Curēus
https://read.qxmd.com/read/34158752/neonatal-hyperbilirubinemia-treatment-by-locally-made-low-cost-phototherapy-units
#27
JOURNAL ARTICLE
Netsanet Workneh Gidi, Matthias Siebeck
BACKGROUND: Hyperbilirubinemia is a very common finding in neonates and may occasionally cause severe morbidity and even mortality. Severe hyperbilirubinemia is typically treated, either with phototherapy or exchange transfusions. This study assessed the effectiveness of a locally manufactured phototherapy device for reducing serum bilirubin in neonates with severe hyperbilirubinemia. METHODS: Retrospective chart review was carried out to assess the outcome of 32 infants who were treated for neonatal hyperbilirubinemia at Jimma Medical Center (JMC) from May, 2017 to April, 2018...
January 2021: Ethiopian Journal of Health Sciences
https://read.qxmd.com/read/34074250/ugt1a1-mutation-association-with-increased-bilirubin-levels-and-severity-of-unconjugated-hyperbilirubinemia-in-abo-incompatible-newborns-of-china
#28
JOURNAL ARTICLE
Hui Yang, Fen Lin, Zi-Kai Chen, Lin Zhang, Jia-Xin Xu, Yong-Hao Wu, Jing-Ying Gu, Yu-Bin Ma, Jian-Dong Li, Li-Ye Yang
BACKGROUND: Neonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form. METHOD: A retrospective study was conducted to review clinical information of ABO hemolysis neonates (ABO HDN) admitted to the Department of Neonatology, referred for neonatal hyperbilirubinemia, in a large general hospital of southern China from 2011 to 2017...
June 1, 2021: BMC Pediatrics
https://read.qxmd.com/read/34047994/causes-of-severe-neonatal-hyperbilirubinemia-a-multicenter-study-of-three-regions-in-china
#29
MULTICENTER STUDY
Xiao-Yue Dong, Qiu-Fen Wei, Zhan-Kui Li, Jie Gu, Dan-Hua Meng, Jin-Zhen Guo, Xiao-Li He, Xiao-Fan Sun, Zhang-Bin Yu, Shu-Ping Han
BACKGROUND: Available evidence suggests that our country bear great burden of severe hyperbilirubinemia. However, the causes have not been explored recently in different regions of China to guide necessary clinical and public health interventions. METHODS: This was a prospective, observational study conducted from March 1, 2018, to February 28, 2019. Four hospitals in three regions of China participated in the survey. Data from infants with a gestational age ≥ 35 weeks, birth weight ≥ 2000 g, and total serum bilirubin (TSB) level ≥ 17 mg/dL (342 µmol/L) were prospectively collected...
June 2021: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/33967007/direct-antiglobulin-test-in-the-prediction-of-hyperbilirubinemia-and-predischarge-bilirubin-levels-in-infants-with-mother-infant-blood-type-incompatibility
#30
JOURNAL ARTICLE
Rajeev Mehta, Anna Petrova
BACKGROUND: This research evaluated the association between the mother-infant blood type or rhesus (ABO or Rh) incompatibility, the pattern of neonatal jaundice, and serum bilirubin (TSB) values obtained prior to discharge from hospital of healthy born neonates with gestational age >34 weeks and birth weight >2000 g. METHODS: We utilized a laboratory and neonatal database to identify the cord blood ABO/Rh and direct antiglobulin test (DAT) and TSB measured during hospitalization and re-admission with hyperbilirubinemia for phototherapy treatment...
July 2021: Pediatrics and Neonatology
https://read.qxmd.com/read/33858132/nucleated-red-blood-cell-levels-in-the-diagnosis-of-patients-with-indirect-hyperbilirubinemia
#31
JOURNAL ARTICLE
Aslihan Köse Cetinkaya, Dilek Kahvecioğlu
BACKGROUND: Nucleated red blood cells (NRBCs) are progenitores of red blood cells that are physiologically seen in the peripheral blood of the fetus and newborn at birth. The increased numbers of NRBCs in the circulation is associated with pathologic conditions such as prematurity, hemolytic diseases and bleeding, intrauterine growth restriction. We aimed to evaluate the relationship between NRBCs and the demographic and clinical characteristics of the patients with indirect hyperbilirubinemia who were followed up in the neonatal intensive care unit...
April 15, 2021: Minerva pediatrics
https://read.qxmd.com/read/33585066/hemolysis-due-to-alpha-hemolytic-enterococcus-urinary-infection-a-rare-cause-of-early-and-severe-unconjugated-hyperbilirubinemia-in-a-neonate
#32
Birol Karabulut, Esin Alpagut Gafil
The reason for reporting this case is to remind that some microorganisms may cause hemolysis leading to early and severe hyperbilirubinemia by secreting hemolysin in cases; where bilirubin levels cannot be successfully decreased despite effective phototherapy, intravenous immunoglobulin, and even exchange transfusion, or in cases of increased rebound bilirubin (although urinary tract infection is associated with increased conjugated bilirubin fraction and prolonged jaundice). The most common causes of hemolysis are ABO/Rh incompatibility and enzyme deficiencies such as glucose-6-phosphate dehydrogenase (G6PDH), pyruvate kinase (PK), and galactose-1-phosphate uridyltransferase (GALT)...
March 2021: Journal of Pediatric Intensive Care
https://read.qxmd.com/read/33395710/role-of-cord-blood-carboxyhemoglobin-in-detecting-significant-hyperbilirubinemia-in-term-neonates-with-abo-alloimmunization
#33
JOURNAL ARTICLE
Mahir Tıraş, Emrah Can, Şahin Hamilçıkan
OBJECTIVE:  This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates with Coombs-positive ABO hemolytic disease than among those with Coombs-negative ABO incompatibility and higher than that of ABO-compatible control neonates. STUDY DESIGN:  This cross-sectional descriptive study of 198 term neonates comprised three subgroups: group I featured 68 DCT-positive ABO-incompatible neonates (ABO + DCT), group II featured 60 DCT-negative ABO-incompatible neonates with hyperbilirubinemia (ABO-DCT), and group III featured 70 healthy controls...
January 4, 2021: American Journal of Perinatology
https://read.qxmd.com/read/33335745/hemolytic-disease-of-fetus-and-newborn-in-a-primigravida-with-multiple-alloantibodies-involving-anti-jk-a-and-anti-e-a-case-report
#34
Salfarina Iberahim, Maryam Jameelah Aizuddin, Nurulhuda Abd Kadir, Nabilah Rameli, Sumaiyah Adzahar, Noor Haslina Mohd Noor, Wan Zaidah Abdullah
The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period...
November 2020: Oman Medical Journal
https://read.qxmd.com/read/32894848/noninvasive-detection-of-hemolysis-with-etcoc-measurement-in-neonates-at-risk-for-significant-hyperbilirubinemia
#35
JOURNAL ARTICLE
Ashwani Bhatia, Mei Chien Chua, Rowena Dela Puerta, Victor Samuel Rajadurai
BACKGROUND: Hemolytic hyperbilirubinemia due to blood group incompatibility or glucose-6-phosphate dehydrogenase deficiency (G6PD) is a common cause of significant hyperbilirubinemia. Hemolysis in a hyperbilirubinemic infant increases the risk of bilirubin neurotoxicity. A new portable device (CoSense) can rapidly detect breath end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc). ETCOc levels are surrogate markers of hemoglobin breakdown and bilirubin production. OBJECTIVE: The aim was to evaluate the association between ETCOc values and hemolysis and its relevance in neonates at risk for significant hyperbilirubinemia...
2020: Neonatology
https://read.qxmd.com/read/32341734/-frequency-and-titration-of-hemolytic-activity-of-anti-a-and-anti-b-antibodies-in-mothers-of-children-with-jaundice-in-yaound%C3%A3-cameroon
#36
JOURNAL ARTICLE
David Sock Sock, Severin Donald Kamdem, Angeline Boula, Palmer Masumbe Netongo
INTRODUCTION: The alloimmunization of the ABO blood group system is involved in neonatal jaundice with a considerable overall prevalence. The role of ABO incompatibility is relatively little known. The purpose of this study was to investigate neonatal jaundice due to feto-maternal ABO incompatibilities and to determine the link between the hemolysins value in the mother and the degree of jaundice observed in the infant. METHODS: We conducted a cross-sectional study from June to November 2015...
2020: Pan African Medical Journal
https://read.qxmd.com/read/32124737/-incidence-and-risk-factors-for-severe-hyperbilirubinemia-in-term-neonates
#37
JOURNAL ARTICLE
Asa Unnur Bergmann, Thordur Thorkelsson
INTRODUCTION: Newborn jaundice is caused by increased levels of bilirubin in the blood of the newborn during the first days after birth. Generally, neonatal jaundice does not need to be treated, however, if the blood bilirubin concentration becomes too high, it can cause neurological damage. Due to the prevalence of neonatal jaundice, it is important to assess its risk factors and their importance. This study at the National University Hospital of Iceland from 1997-2018, determines the risk factors for severe neonatal jaundice and their significance...
2020: Læknablađiđ
https://read.qxmd.com/read/32052364/etiology-and-therapeutic-management-of-neonatal-jaundice-in-iran-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Yadollah Zahed Pasha, Shaghayegh Alizadeh-Tabari, Ermia Zahed Pasha, Mohammad Zamani
BACKGROUND: Jaundice is a life-threatening disorder in the neonates. In the present study, we aimed to assess systematically available evidence on causes and management of jaundice in Iranian newborn patients. METHODS: We searched the databases of PubMed, Web of Sciences, Scopus and Google Scholar for English articles published since inception until May 2019. A search was also done for Persian articles in Magiran and Scientific Information Database. Studies were evaluated based on predefined criteria by two reviewers...
October 2020: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/31729720/abo-hemolytic-disease-of-newborn-does-newborn-s-blood-group-a-risk-factor
#39
COMPARATIVE STUDY
Imen Bel Hadj, Riadh Boukhris, Fatma Khalsi, Manel Namouchi, Iheb Bougmiza, Faten Tinsa, Samia Hamouda, Khadija Boussetta
BACKGROUND: Due to the marked decline of maternal-fetal rhesus incompatibility, ABO alloimmunization has become the leading cause of the newborn hemolytic disease. It is estimated that 15-25 % of all pregnancies are concerned by ABO incompatibility. AIM: Neonatal blood group B seems to be more predisposing to acute hemolysis and severe hyperbilirubinemia. We propose to find if the newborn's blood group B represents a risk factor for severe hemolysis and/or severe hyperbilirubinemia...
March 2019: La Tunisie Médicale
https://read.qxmd.com/read/31692740/hemolytic-anemia-caused-by-non-d-minor-blood-incompatibilities-in-a-newborn
#40
Ali Ulas Tugcu, Deniz Anuk Ince, Ozden Turan, Burcu Belen, Lale Olcay, Ayse Ecevit
Hyperbilirubinemia is one of the most widely seen cause of neonatal morbidity. Besides ABO and Rh isoimmunization, minor blood incompatibilities have been also been identified as the other causes of severe newborn jaundice. We report a newborn with indirect hyperbilirubinemia caused by minor blood group incompatibilities (P1, M, N, s and Duffy) whose hemolysis was successfully managed with intravenous immunoglobulin therapy. A thirty-two gestational weeks of preterm male baby became severely icteric on postnatal day 11, with a total bilirubin level of 14...
2019: Pan African Medical Journal
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