Simona Daniela Neamţu, Marius Bogdan Novac, Adela Valeria Neamţu, Iulia Diana Stanca, Mihail Virgil Boldeanu, Adrian Gluhovschi, Liliana Stanca, Anda Lorena Dijmărescu, Maria Magdalena Manolea, Magdalena Rodica Trăistaru, Garofiţa Olivia Mateescu, Mirela Anişoara Siminel
Next to A and B antigens, agglutinogen D exhibits the highest immunogenicity. Following the transfusion of D-positive red blood cells (RBCs), almost 80% of D-negative recipients develop anti-D antibodies (Abs). Subsequently, anti-D immunization further promotes the synthesis of Abs towards other blood group antigens in or outside the Rh system. The D antigen is also involved in 95% of cases of hemolytic disease of the newborn. Transfusions, hemotherapy, grafts, and obstetric history (abortions, ectopic pregnancy, births) are all risk factors for Rh isoimmunization...
January 2022: Romanian Journal of Morphology and Embryology