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https://www.readbyqxmd.com/read/29261309/bioinspired-heterogeneous-ion-pump-membranes-unidirectional-selective-pumping-and-controllable-gating-properties-stemming-from-asymmetric-ionic-group-distribution
#1
Zhen Zhang, Pei Li, Xiang-Yu Kong, Ganhua Xie, Yongchao Qian, Ziqi Wang, Ye Tian, Liping Wen, Lei Jiang
The creation of artificial solid-state ion pump that mimics the delicate ion transport behaviors of biological protein-based ion pump is drawing more and more research attention due to its potential applications in energy conversion, biosensor, and desalination. However, the reported bioinspired double-gated ion pump systems are generally very primary, and can only realize non-selective ion pumping functions with no directionality and uncontrollable ion gating functions, which are far from their biological counterparts...
December 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29258525/advancing-perinatal-patient-safety-through-application-of-safety-science-principles-using-health-it
#2
Jennifer Webb, Asta Sorensen, Samantha Sommerness, Beth Lasater, Kamila Mistry, Leila Kahwati
BACKGROUND: The use of health information technology (IT) has been shown to promote patient safety in Labor and Delivery (L&D) units. The use of health IT to apply safety science principles (e.g., standardization) to L&D unit processes may further advance perinatal safety. METHODS: Semi-structured interviews were conducted with L&D units participating in the Agency for Healthcare Research and Quality's (AHRQ's) Safety Program for Perinatal Care (SPPC) to assess units' experience with program implementation...
December 19, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29216107/fabrication-of-ultra-high-numerical-aperture-geo2-doped-fiber-and-its-use-for-broadband-supercontinuum-generation
#3
P Harshavardhan Reddy, A V Kir'yanov, Anirban Dhar, Shyamal Das, Debjit Dutta, Mrinmay Pal, Y O Barmenkov, J A Minguella-Gallardo, Shyamal Kumar Bhadra, Mukul Chandra Paul
We report the fabrication, characterization, and application (broadband supercontinuum [SC] generation) of ultra-high numerical-aperture heavily (50 mol. %) GeO2-doped optical fiber, obtained through a modified chemical vapor deposition process and rod-in-tube method. The formation of Ge-related diamagnetic defect centers, such as germanium oxygen defect centers (GeODC) with nonbridging lone electron pairs, confirmed by x-ray photoelectron spectroscopy and optical absorption studies, inducing hypolarizable local dipoles, may be responsible in boosting the nonlinear effects and enhancing stimulated Raman scattering at pumping with high-power pulses, culminating in generation of broadband SC generation...
November 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29212333/-quo-vadis-diabetes-technology
#4
George Grunberger
Management of patients with diabetes mellitus who require intensive insulin therapy has changed dramatically. From urine and then whole blood glucose monitoring patients can now wear personal continuous glucose monitors; from using multiple insulin injections they can now deliver subcutaneous insulin continuously using ever-more sophisticated insulin pumps. With the current integration of continuous glucose monitoring and insulin pumps a new era is arriving when "smart" insulin pumps can automate insulin delivery to assure more stable glycemic control while minimizing episodes of hypoglycemia...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29212332/quo-vadis-diabetes-technology
#5
George Grunberger
Management of patients with diabetes mellitus who require intensive insulin therapy has changed dramatically. From urine and then whole blood glucose monitoring patients can now wear personal continuous glucose monitors; from using multiple insulin injections they can now deliver subcutaneous insulin continuously using ever-more sophisticated insulin pumps. With the current integration of continuous glucose monitoring and insulin pumps a new era is arriving when "smart" insulin pumps can automate insulin delivery to assure more stable glycemic control while minimizing episodes of hypoglycemia...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29171371/-safe-medication-administration-in-hospitals
#6
W van der Veen, K Taxis, P M L A van den Bemt
- Every day medication is administered to thousands of hospital inpatients, and medication administration errors can occur.- Interventions to reduce medication administration errors have been developed and tested; these include training, double-checking procedures, and technological solutions (such as smart infusion pumps and barcode-controlled drug administration).- Most of the studies that investigated these interventions were small, meaning it is unclear which intervention is the most effective. More research is needed to identify the best solutions...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29152973/epidermal-microfluidic-electrochemical-detection-system-enhanced-sweat-sampling-and-metabolite-detection
#7
Aida Martin, Jayoung Kim, Jonas F Kurniawan, Juliane R Sempionatto, Jose R Moreto, Guangda Tang, Alan C Campbell, Andrew Shin, Min Yul Lee, Xiaofeng Liu, Joseph Wang
Despite tremendous recent efforts, non-invasive sweat monitoring is still far from delivering its early analytical promise. Here, we describe a flexible epidermal microfluidic detection platform fabricated through hybridization of lithographic and screen-printed technologies for efficient sweat sampling and continuous real-time electrochemical monitoring of sweat glucose and lactate levels. This soft, skin-mounted device judiciously merges lab-on-a-chip and electrochemical detection technologies, integrated with a miniaturized flexible electronic board for real-time wireless data transmission to a smart device...
November 20, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28879317/the-evaluation-of-implementing-smart-patient-controlled-analgesic-pump-with-a-different-infusion-rate-for-different-time-duration-on-postoperative-pain-management
#8
Saeyoung Kim, Younghoon Jeon, Hyeonjun Lee, Jung A Lim, Sungsik Park, Si Oh Kim
BACKGROUND: Control of postoperative pain is an important aspect of postoperative patient management. Among the methods of postoperative pain control, patient-controlled analgesia (PCA) has been the most commonly used. This study tested the convenience and safety of a PCA method in which the dose adjusted according to time. METHODS: This study included 100 patients who had previously undergone orthognathic surgery, discectomy, or total hip arthroplasty, and wished to control their postoperative pain through PCA...
December 2016: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28861639/repositioning-of-proton-pump-inhibitors-in-cancer-therapy
#9
REVIEW
Zhen-Ning Lu, Bing Tian, Xiu-Li Guo
Drug repositioning, as a smart way to exploit new molecular targets of a known drug, has been gaining increasing attention in the discovery of anti-cancer drugs. Proton pump inhibitors (PPIs) as benzimidazole derivatives, which are essentially H+-K+-ATPases inhibitors, are commonly used in the treatment of acid-related diseases such as gastric ulcer. In recent years, exploring the new application of PPIs in anti-cancer field has become a hot research topic. Interestingly, cancer cells display an alkaline intracellular pH and an acidic extracellular pH...
November 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28857619/evaluation-of-the-performance-of-elastomeric-pumps-in-practice-are-we-under-delivering-on-chemotherapy-treatments
#10
Dahlia Salman, Jurga Biliune, Reem Kayyali, Jane Ashton, Peter Brown, Tim McCarthy, Elin Vikman, Stephen Barton, Julian Swinden, Shereen Nabhani-Gebara
BACKGROUND AND AIMS: Elastomeric pumps are widely used to facilitate ambulatory chemotherapy, and studies have shown that they are safe and well received by patients. Despite these advantages, their end of infusion time can fluctuate significantly. The aim of this research was to observe the performance of these pumps in real practice and to evaluate patients' satisfaction. METHODS: This was a two-phase study conducted at three cancer units over 6 months. Phase-1 was an observational study recording the status of pumps at the scheduled disconnection time and noting remaining volume of infusion...
October 30, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28796753/comparative-study-of-radon-concentration-with-two-techniques-and-elemental-analysis-in-drinking-water-samples-of-the-jammu-district-jammu-and-kashmir-india
#11
COMPARATIVE STUDY
Ajay Kumar, Manpreet Kaur, Rohit Mehra, Dinesh Kumar Sharma, Rosaline Mishra
The level of radon concentration has been assessed using the Advanced SMART RnDuo technique in 30 drinking water samples from Jammu district, Jammu and Kashmir, India. The water samples were collected from wells, hand pumps, submersible pumps, and stored waters. The randomly obtained 14 values of radon concentration in water sources using the SMART RnDuo technique have been compared and cross checked by a RAD7 device. A good positive correlation (R = 0.88) has been observed between the two techniques. The overall value of radon concentration in various water sources has ranged from 2...
October 2017: Health Physics
https://www.readbyqxmd.com/read/28734227/continuous-delivery-of-neutralizing-antibodies-elevate-ccl2-levels-in-mice-bearing-mcf10ca1d-breast-tumor-xenografts
#12
Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng
Chemokines are small soluble molecules that play critical roles in wound healing, infection, and cancer progression. In particular, overexpression of the C-C motif chemokine ligand 2 (CCL2) in multiple cancer types correlates with poor patient prognosis. Animal studies have shown that CCL2 signals to macrophages and breast cancer cells to promote tumor growth, invasion, and metastasis, indicating that CCL2 is a promising therapeutic target. However, the effectiveness of human-specific neutralizing antibodies has not been fully evaluated...
October 2017: Translational Oncology
https://www.readbyqxmd.com/read/28653940/review-medication-errors-and-strategies-for-their-prevention
#13
REVIEW
Muhammad Kashif Riaz, Mohammad Riaz, Abida Latif
Medication errors occur every day causing injury to the patients and even deaths. The health care professionals are not fully aware of the damages done by medication errors in terms of patients' discomfort and economic burden. There is a need to provide information about medication errors to health care providers. This article reviews research done on the various aspects of medication errors. The research work done on prescribing errors, transcribing errors, dispensing errors, administration errors and discharged summaries errors have been examined...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28645817/dumb-pumps-smart-flow-and-a-genius
#14
EDITORIAL
Ashish S Shah
No abstract text is available yet for this article.
September 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28604571/hvad-waveform-analysis-as-a-noninvasive-marker-of-pulmonary-capillary-wedge-pressure-a-first-step-toward-the-development-of-a-smart-left-ventricular-assist-device-pump
#15
Jonathan Grinstein, Daniel Rodgers, Sara Kalantari, Gabriel Sayer, Gene H Kim, Nitasha Sarswat, Sirtaz Adatya, Takeyoshi Ota, Valluvan Jeevanandam, Daniel Burkhoff, Nir Uriel
Flow waveforms are an important feature of the HVAD left ventricular assist device (LVAD) that provides information about HVAD function and patient hemodynamics. We assessed the properties of one specific aspect of the waveform, the slope of the ventricular filling phase (VFP), and its correlation with pulmonary capillary wedge pressure (PCWP). A total of 101 screenshots from the HVAD monitor and simultaneous hemodynamic measurements were obtained simultaneously during sequential stages of invasive hemodynamic ramp studies...
June 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28578750/using-the-health-technology-assessment-toolbox-to-facilitate-procurement-the-case-of-smart-pumps-in-a-canadian-hospital
#16
Thomas G Poder
OBJECTIVES: The aim of this study was to present the experience of a Canadian hospital-based health technology assessment (HTA) unit that performed the traditional functions of the HTA process along with many other activities to facilitate the choice of smart pumps. METHODS: A rapid literature review was initiated, but little evidence was found. Moreover, the evidence provided was too far from our hospital context. To help our decision makers, we offered them a list of various services based on the skills of our HTA unit staff...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28574959/intravenous-smart-pump-drug-library-compliance-a-descriptive-study-of-44-hospitals
#17
Karen K Giuliano, Wan-Ting Su, Daniel D Degnan, Kristy Fitzgerald, Richard J Zink, Poching DeLaurentis
BACKGROUND: Although intravenous (IV) smart pumps with built-in dose-error reduction systems (DERS) can reduce IV medication administration error, most serious adverse events still occur during IV medication administration. Sources of error include overriding DERS and manually bypassing drug libraries and the DERS. METHODS: Our purpose was to use the Regenstrief National Center for Medical Device Informatics data set to better understand IV smart pump drug library and DERS compliance...
June 1, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28574182/optimizing-the-combination-insulin-bolus-split-for-a-high-fat-high-protein-meal-in-children-and-adolescents-using-insulin-pump-therapy
#18
P E Lopez, C E Smart, P McElduff, D C Foskett, D A Price, M A Paterson, B R King
AIMS: To determine the optimum combination bolus split to maintain postprandial glycaemia with a high-fat and high-protein meal in young people with Type 1 diabetes. METHODS: A total of 19 young people (mean age 12.9 ± 6.7 years) participated in a randomized, repeated-measures trial comparing postprandial glycaemic control across six study conditions after a high-fat and high-protein meal. A standard bolus and five different combination boluses were delivered over 2 h in the following splits: 70/30 = 70% standard /30% extended bolus; 60/40=60% standard/40% extended bolus; 50/50=50% standard/50% extended bolus; 40/60=40% standard/60% extended bolus; and 30/70=30% standard/70% extended bolus...
June 2, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28453325/implementing-smart-infusion-pumps-with-dose-error-reduction-software-real-world-experiences
#19
Claire Heron
Intravenous (IV) drug administration, especially with 'smart pumps', is complex and susceptible to errors. Although errors can occur at any stage of the IV medication process, most errors occur during reconstitution and administration. Dose-error reduction software (DERS) loaded on to infusion pumps incorporates a drug library with predefined upper and lower drug dose limits and infusion rates, which can reduce IV infusion errors. Although this is an important advance for patient safety at the point of care, uptake is still relatively low...
April 27, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28421749/design-of-multifunctional-nanogate-in-response-to-multiple-external-stimuli-using-amphiphilic-diblock-copolymer
#20
Kai Huang, Igal Szleifer
Nature uses the interplay between hydrophobic and electrostatic interactions of disordered proteins to orchestrate complicated molecular gates such as the nuclear pore complex to control the transport of biological masses. Inspired by nature, we here theoretically show that well-defined gate shape, sensitive response to pH and salt concentration, and selectivity in cargo transport can be simultaneously achieved by grafting amphiphilic diblock copolymers made of sequence-controlled hydrophobic and ionizable monomers on the inner surface of solid-state nanopore...
April 28, 2017: Journal of the American Chemical Society
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