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https://www.readbyqxmd.com/read/30334381/rescue-from-lethal-acute-radiation-syndrome-ars-with-severe-weight-loss-by-secretome-of-intramuscularly-injected-human-placental-stromal-cells
#1
Lena Pinzur, Levent Akyuez, Lilia Levdansky, Michal Blumenfeld, Evgenia Volinsky, Zami Aberman, Petra Reinke, Racheli Ofir, Hans-Dieter Volk, Raphael Gorodetsky
BACKGROUND: Most current cell-based regenerative therapies are based on the indirect induction of the affected tissues repair. Xenogeneic cell-based treatment with expanded human placenta stromal cells, predominantly from fetal origin (PLX-RAD cells), were shown to mitigate significantly acute radiation syndrome (ARS) following high dose irradiation in mice, with expedited regain of weight loss and haematopoietic function. The current mechanistic study explores the indirect effect of the secretome of PLX-RAD cells in the rescue of the irradiated mice...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/30327133/seasonal-trend-of-ventricular-arrhythmias-in-a-nationwide-remote-monitoring-database-of-implantable-defibrillators-and-cardiac-resynchronization-devices
#2
Vincenzo Russo, Francesco Solimene, Gabriele Zanotto, Ennio C Pisanò, Paolo Della Bella, Saverio Iacopino, Carlo Pignalberi, Valeria Calvi, Giampiero Maglia, Fabio Quartieri, Mauro Biffi, Antonio Curnis, Daniele Giacopelli, Alessio Gargaro, Antonio D'Onofrio
BACKGROUND: The occurrence of sustained ventricular arrhythmias (SVA) may be influenced by environmental factors. We aimed to investigate annual periodic trends of SVA from the intracardiac electrograms (IEGMs) stored in the implantable defibrillators (ICDs) or cardiac resynchronization therapy (CRT-D) recipients. METHODS: Data from the Home Monitoring Expert Alliance project, a pooled repository of remote monitoring transmissions were analyzed. All IEGMs stored were independently adjudicated by three cardiac electrophysiologists...
October 10, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30322864/the-gut-microbiome-relationships-with-disease-and-opportunities-for-therapy
#3
REVIEW
Juliana Durack, Susan V Lynch
Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function...
October 15, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/30316298/polymer-coated-gold-ferric-oxide-superparamagnetic-nanoparticles-for-theranostic-applications
#4
Muhammad Raisul Abedin, Siddesh Umapathi, Harika Mahendrakar, Tunyaboon Laemthong, Holly Coleman, Denise Muchangi, Santimukul Santra, Manashi Nath, Sutapa Barua
BACKGROUND: Engineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-L-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and the internalization of the NPs toward living mammalian cells is profoundly affected...
October 13, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/30314688/survival-after-surgical-ablation-for-atrial-fibrillation-in-mitral-valve-surgery-analysis-from-the-polish-national-registry-of-cardiac-surgery-procedures-krok
#5
Piotr Suwalski, Mariusz Kowalewski, Marek Jasiński, Jakub Staromłyński, Marian Zembala, Kazimierz Widenka, Mirosław Brykczyński, Jacek Skiba, Michał Oskar Zembala, Krzysztof Bartuś, Tomasz Hirnle, Inga Dziembowska, Zdzisław Tobota, Bohdan J Maruszewski
OBJECTIVES: Surgical ablation for atrial fibrillation (AF) performed at the time of other valvular- or nonvalvular cardiac procedure is a mainstay of therapy; yet the data regarding its influence on remote survival are sparse. We aimed to evaluate late survival in patients undergoing mitral valve (MV) surgery with concomitant surgical ablation for AF. METHODS: Procedure-related data from the Polish National Registry of Cardiac Surgery Procedures (Krajowy Rejestr Operacji Kardiochirurgicznych) were retrospectively collected...
September 8, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30310998/the-10th-biennial-hatter-cardiovascular-institute-workshop-cellular-protection-evaluating-new-directions-in-the-setting-of-myocardial-infarction-ischaemic-stroke-and-cardio-oncology
#6
REVIEW
Sean M Davidson, Sapna Arjun, Maryna V Basalay, Robert M Bell, Daniel I Bromage, Hans Erik Bøtker, Richard D Carr, John Cunningham, Arjun K Ghosh, Gerd Heusch, Borja Ibanez, Petra Kleinbongard, Sandrine Lecour, Helen Maddock, Michel Ovize, Malcolm Walker, Marlene Wiart, Derek M Yellon
Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy...
October 11, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/30306305/-telemonitoring-of-implanted-cardiac-devices-clinical-necessity-or-senseless-luxury
#7
REVIEW
Michael Döring, Sergio Richter, Helge Knopp, Gerhard Hindricks
In addition to the telemedical follow-up at a fixed point in time, there is the possibility of a close-meshed telemetric monitoring in modern devices. By transferring device and patient-specific data, errors in the integrity of the device or electrodes and cardiac arrhythmias can be detected early, in various studies significantly reducing the number of outpatient or inpatient visits and the rate of inadequate implantable cardioverter-defibrillator (ICD) therapies. Measurement of various surrogate parameters allows better clinical assessment of heart failure patients, yet no improvement in outcome with therapy guided by telemetric data has been demonstrated...
October 10, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/30305148/psychological-support-for-personality-psp-versus-treatment-as-usual-study-protocol-for-a-feasibility-randomized-controlled-trial-of-a-low-intensity-intervention-for-people-with-personality-disorder
#8
Mike J Crawford, Lavanya Thana, Jennie Parker, Oliver Turner, Kwek Pei Xing, Mary McMurran, Paul Moran, Timothy Weaver, Barbara Barrett, Amy Claringbold, Paul Bassett, Rahil Sanatinia
BACKGROUND: Previous research has demonstrated the clinical effectiveness of long-term psychological treatment for people with some types of personality disorder. However, the high intensity and cost of these interventions limit their availability. Lower-intensity interventions are increasingly being offered to people with personality disorder, but their clinical and cost effectiveness have not been properly tested in experimental studies. We therefore set out to develop a low intensity intervention for people with personality disorder and to test the feasibility of conducting a randomized controlled trial to compare the clinical effectiveness of this intervention with that of treatment as usual (TAU)...
October 10, 2018: Trials
https://www.readbyqxmd.com/read/30301955/fasting-enhances-extinction-retention-and-prevents-the-return-of-fear-in-humans
#9
Le Shi, Jiahui Deng, Sijing Chen, Jianyu Que, Yekun Sun, Zhong Wang, Xiaojie Guo, Ying Han, Yuxin Zhou, Xiujun Zhang, Wen Xie, Xiao Lin, Jie Shi, Lin Lu
Fear is prone to return following extinction that is the basis of exposure therapy for fear-related disorders. Manipulations that enhance the extinction process can be beneficial for treatment. Animal studies have shown that fasting or caloric restriction can enhance extinction and inhibit the return of fear. The present study examined the effects of fasting on fear acquisition, extinction, and the return of fear in humans. One hundred and twenty-five male participants were randomized into a fasting group and food group and exposed to a Pavlovian fear conditioning paradigm...
October 9, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30301384/speech-driven-mobile-games-for-speech-therapy-user-experiences-and-feasibility
#10
Beena Ahmed, Penelope Monroe, Adam Hair, Chek Tien Tan, Ricardo Gutierrez-Osuna, Kirrie J Ballard
PURPOSE: To assist in remote treatment, speech-language pathologists (SLPs) rely on mobile games, which though entertaining, lack feedback mechanisms. Games integrated with automatic speech recognition (ASR) offer a solution where speech productions control gameplay. We therefore performed a feasibility study to assess children's and SLPs' experiences towards speech-controlled games, game feature preferences and ASR accuracy. METHOD: Ten children with childhood apraxia of speech (CAS), six typically developing (TD) children and seven SLPs trialled five games and answered questionnaires...
October 9, 2018: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/30299428/pharmacodynamic-monitoring-of-biological-therapies-in-chronic-inflammatory-diseases
#11
Erwin Dreesen, Ann Gils
BACKGROUND: Psoriasis, psoriatic arthritis, spondyloarthritis, rheumatoid arthritis, ulcerative colitis and Crohn's disease share similar underlying pathophysiological processes, providing the opportunity to treat the patients using similar biological therapies. Failure of biological treatments due to underexposure can be managed by therapeutic drug monitoring. Adjusting the treatment based on pharmacokinetic monitoring can be further improved by taking pharmacodynamic parameters such as clinical and molecular markers into account...
October 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/30293160/wearable-sensors-to-monitor-enable-feedback-and-measure-outcomes-of-activity-and-practice
#12
REVIEW
Bruce H Dobkin, Clarisa Martinez
PURPOSE OF REVIEW: Measurements obtained during real-world activity by wearable motion sensors may contribute more naturalistic accounts of clinically meaningful changes in impairment, activity, and participation during neurologic rehabilitation, but obstacles persist. Here we review the basics of wearable sensors, the use of existing systems for neurological and rehabilitation applications and their limitations, and strategies for future use. RECENT FINDINGS: Commercial activity-recognition software and wearable motion sensors for community monitoring primarily calculate steps and sedentary time...
October 6, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/30291146/optogenetic-medicine-synthetic-therapeutic-solutions-precision-guided-by-light
#13
Haifeng Ye, Martin Fussenegger
Gene- and cell-based therapies are well recognized as central pillars of next-generation medicine, but controllability remains a critical issue for clinical applications. In this context, optogenetics is opening up exciting new opportunities for precision-guided medicine by using illumination with light of appropriate intensity and wavelength as a trigger signal to achieve pinpoint spatiotemporal control of cellular activities, such as transgene expression. In this review, we highlight recent advances in optogenetics, focusing on devices for biomedical applications...
October 5, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/30290777/development-of-a-3d-networked-multi-user-virtual-reality-environment-for-home-therapy-after-stroke
#14
Kristen M Triandafilou, Daria Tsoupikova, Alexander J Barry, Kelly N Thielbar, Nikolay Stoykov, Derek G Kamper
BACKGROUND: Impairment of upper extremity function is a common outcome following stroke, to the detriment of lifestyle and employment opportunities. Yet, access to treatment may be limited due to geographical and transportation constraints, especially for those living in rural areas. While stroke rates are higher in these areas, stroke survivors in these regions of the country have substantially less access to clinical therapy. Home therapy could offer an important alternative to clinical treatment, but the inherent isolation and the monotony of self-directed training can greatly reduce compliance...
October 5, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/30288324/-b-in-it-a-community-based-model-for-the-management-of-hepatitis-b-patients-in-primary-care-clinics-using-a-novel-web-based-clinical-tool
#15
Debra A O'Leary, Eleanor Cropp, David Isaac, Paul V Desmond, Sally Bell, Tin Nguyen, Darren Wong, Jessica Howell, Jacqui Richmond, Jenny O'Neill, Alexander J Thompson
Background: The current model of care for the treatment of chronic hepatitis B (CHB) in Australia is through specialist Hepatology or Infectious Diseases clinics, and limited accredited primary care practices. Capacity is limited, and less than 5% of Australians living with CHB currently access therapy. Increasing treatment uptake is an urgent area of clinical need. Nucleos(t)ide analogue therapy is safe and effective treatment for CHB that is suitable for community prescribing. We have evaluated the success of a community-based model for the management of CHB in primary care clinics using a novel web-based clinical tool...
2018: Hepatology, Medicine and Policy
https://www.readbyqxmd.com/read/30281821/transcranial-direct-current-stimulation-tdcs-reduces-nociceptive-behavior-in-an-orofacial-pain-model
#16
Vanessa L Scarabelot, Carla de Oliveira, Liciane F Medeiros, Isabel C de Macedo, Stefania G Cioato, Lauren Naomi S Adachi, Ana Helena Paz, Andressa de Souza, Wolnei Caumo, Iraci L S Torres
BACKGROUND: transcranial Direct Current Stimulation (tDCS) is a non-invasive method of brain stimulation suggested as a therapeutic tool for pain, and is related to reversal of maladaptive plasticity associated with chronic pain. OBJECTIVES: this study investigated the effect of tDCS, a non-pharmacological therapy, on local mechanical hyperalgesia, and remote thermal hyperalgesia in rats submitted to orofacial inflammatory pain model, by facial von Frey and hot plate tests, respectively...
October 3, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/30278024/future-strategies-for-remote-damage-control-resuscitation-after-traumatic-hemorrhage
#17
David N Naumann, Mansoor A Khan, Jason E Smith, Rory Rickard, Tom Woolley
One of the key elements of remote damage control resuscitation (RDCR) is a hemostatic resuscitation strategy to prevent the triad of coagulopathy, acidosis and hypothermia. Transfusion of whole blood has been an effective solution for both military and civilian patients, and appears to be superior to individual component therapy. At first, whole blood seems to be the ideal solution for RDCR, but it has some clinical and logistic drawbacks that may limit its use in the prehospital, battlefield, austere, and remote settings, or during multiple casualty or massive transfusion scenarios...
October 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30275652/variation-in-the-geographic-distribution-of-physiotherapy-student-clinical-placements-in-rural-saskatchewan
#18
Tayyab I Shah, Stephan Milosavljevic, Peggy L Proctor, Arlis M McQuarrie, Cathy Cuddington, Brenna Bath
Purpose: Rural and remote Saskatchewan has a shortage of physiotherapists. Positive student experiences in rural and remote communities may influence whether graduates choose to work in these settings. The intention of the first full-time, 4-week clinical placement (CP) in the Master of Physical Therapy programme at the University of Saskatchewan is to provide clinical experiences in rural settings outside Saskatoon and Regina. This study examines the geographic distribution of and yearly variation in these CPs to determine whether this stated intent is being realized...
2018: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/30274638/the-delivery-of-cardiac-rehabilitation-using-communications-technologies-the-virtual-cardiac-rehabilitation-program
#19
REVIEW
Scott A Lear
Cardiac rehabilitation (CR) programs are a proven therapy for patients with cardiovascular disease, reducing future cardiac events and premature mortality. However, as little as 10% of eligible patients attend these programs, with a key reason being geographical inaccessibility. In Canada, more than 90% of Canadians have Internet access, and there are approximately 31 million cell phone subscribers, with these numbers expected to continue to increase. The proliferation of these affordable communications technologies has opened up opportunities for patient communication while bridging geographic distance...
October 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/30274306/photo-magnetic-irradiation-mediated-multimodal-therapy-of-neuroblastoma-cells-using-a-cluster-of-multifunctional-nanostructures
#20
Rohini Atluri, Rahul Atmaramani, Gamage Tharaka, Thomas McCallister, Jian Peng, David Diercks, Somesree GhoshMitra, Santaneel Ghosh
The use of high intensity chemo-radiotherapies has demonstrated only modest improvement in the treatment of high-risk neuroblastomas. Moreover, undesirable drug specific and radiation therapy-incurred side effects enhance the risk of developing into a second cancer at a later stage. In this study, a safer and alternative multimodal therapeutic strategy involving simultaneous optical and oscillating (AC) magnetic field stimulation of a multifunctional nanocarrier system has successfully been implemented to guide neuroblastoma cell destruction...
September 29, 2018: Nanomaterials
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