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https://www.readbyqxmd.com/read/28445295/metastatic-breast-cancer-to-the-rectum-a-case-report-with-emphasis-on-mri-features
#1
Li Ching Lau, Bernard Wee, Shi Wang, Yee Liang Thian
RATIONALE: Less than 1% of breast carcinomas metastasize to the gastrointestinal tract. The diagnosis is frequently not recognized especially when the history of breast carcinoma is remote. PATIENT CONCERNS: A 61-year-old female with a remote history of breast carcinoma presented with a 3-month history of change in bowel habits. Colonoscopy showed a circumferential rectal mass with initial impression of primary rectal cancer. MRI of the rectum showed findings that are atypical for primary rectal cancer...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445286/remote-ischemic-preconditioning-improves-the-cognitive-function-of-elderly-patients-following-colon-surgery-a-randomized-clinical-trial
#2
Zhenqiu He, Nan Xu, Sihua Qi
BACKGROUND: Cognitive function impairment is one of the most common complications in elderly patients after surgery, and an ideal nonpharmacological therapy has not yet been identified. Thus, we hypothesized that remote ischemic preconditioning could improve cognitive functions in elderly patients after surgery and investigated the mechanism underlying this effect. METHODS: Ninety patients classified as American Society of Anaesthesiologists (ASA) physical status of 2 or 3 and aged 65 to 75 years who were scheduled for elective colon surgery under general anesthesia were randomly allocated to either a remote ischemic preconditioning group (Group R, n = 45) or a control group (Group C, n = 45)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441928/canadian-stroke-best-practice-recommendations-telestroke-best-practice-guidelines-update-2017
#3
Dylan Blacquiere, M Patrice Lindsay, Norine Foley, Colleen Taralson, Susan Alcock, Catherine Balg, Sanjit Bhogal, Julie Cole, Marsha Eustace, Patricia Gallagher, Antoinette Ghanem, Alexander Hoechsmann, Gary Hunter, Khurshid Khan, Alier Marrero, Brian Moses, Kelley Rayner, Andrew Samis, Elisabeth Smitko, Marilyn Vibe, Gord Gubitz, Dariush Dowlatshahi, Stephen Phillips, Frank L Silver
Every year, approximately 62,000 people with stroke and transient ischemic attack are treated in Canadian hospitals. The 2016 update of the Canadian Stroke Best Practice Recommendations Telestroke guideline is a comprehensive summary of current evidence-based and consensus-based recommendations appropriate for use by all healthcare providers and system planners who organize and provide care to patients following stroke across a broad range of settings. These recommendations focus on the use of telemedicine technologies to rapidly identify and treat appropriate patients with acute thrombolytic therapies in hospitals without stroke specialized expertise; select patients who require to immediate transfer to stroke centers for Endovascular Therapy; and for the patients who remain in community hospitals to facilitate their care on a stroke unit and provide remote access to stroke prevention and rehabilitation services...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28437566/physical-therapists-perceptions-of-telephone-and-internet-video-mediated-service-models-for-exercise-management-of-people-with-osteoarthritis
#4
Belinda J Lawford, Kim L Bennell, Jessica Kasza, Rana S Hinman
OBJECTIVE: Investigate physical therapists' perceptions of, and willingness to use, telephone- and internet-mediated service models for exercise therapy for people with knee and/or hip osteoarthritis. METHODS: An internet-based survey of Australian physical therapists comprising three sections: i) demographic information; and 16 positively-framed perception statements about delivering exercise via ii) telephone and; iii) video over the internet, for people with hip and/or knee osteoarthritis...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437377/microrna-21-is-required-for-local-and-remote-ischemic-preconditioning-in-multiple-organ-protection-against-sepsis
#5
Ping Jia, Xiaoli Wu, Yan Dai, Jie Teng, Yi Fang, Jiachang Hu, Jianzhou Zou, Mingyu Liang, Xiaoqiang Ding
OBJECTIVE: Sepsis, triggered by microbial infection, is a common and life-threatening systemic illness, often leads to impaired function of vital organs. Ischemic preconditioning induced by transient brief episodes of ischemia is a powerful innate mechanism of organ protection. We have reported that a 15-minute renal ischemic preconditioning substantially attenuated subsequent renal ischemia-reperfusion injury. Here, we investigate whether a brief ischemia and reperfusion in kidney can provide protection at local and remote sites against sepsis-induced organ injury, and whether this protection is microRNA-21 dependent...
April 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28435174/therapist-training-on-cognitive-behavior-therapy-for-anxiety-disorders-using-internet-based-technologies
#6
Kenneth A Kobak, Kate Wolitzky-Taylor, Michelle G Craske, Raphael D Rose
This study investigated a technology-enhanced training protocol to facilitate dissemination of therapist training on cognitive behavior therapy (CBT) for anxiety disorders. Seventy community clinicians received an online tutorial followed by live remote observation of clinical skills via videoconference. Impact of training on patient outcomes was also assessed. Training resulted in a significant increase in both trainee knowledge of CBT concepts and techniques and therapist competence in applying these skills...
April 2017: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/28424144/expertise-and-infrastructure-capacity-impacts-acute-coronary-syndrome-outcomes
#7
Carolyn M Astley, Isuru Ranasinghe, David Brieger, Chris J Ellis, Julie Redfern, Tom Briffa, Bernadette Aliprandi-Costa, Tegwen Howell, Stephen G Bloomer, Greg Gamble, Andrea Driscoll, Karice K Hyun, Chris J Hammett, Derek P Chew
Objective Effective translation of evidence to practice may depend on systems of care characteristics within the health service. The present study evaluated associations between hospital expertise and infrastructure capacity and acute coronary syndrome (ACS) care as part of the SNAPSHOT ACS registry.Methods A survey collected hospital systems and process data and our analysis developed a score to assess hospital infrastructure and expertise capacity. Patient-level data from a registry of 4387 suspected ACS patients enrolled over a 2-week period were used and associations with guideline care and in-hospital and 6-, 12- and 18-month outcomes were measured...
April 20, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28406429/release-of-doxorubicin-by-a-folate-grafted-chitosan-coated-magnetic-nanoparticle
#8
Chung-Lin Yang, Jyh-Ping Chen, Kuo-Chen Wei, Ju-Yu Chen, Chia-Wen Huang, Zi-Xian Liao
In clinical tumor therapy, chemotherapeutic routes have caused severe side effects; current delivery methods are unsatisfactory. Successful design of a remotely folate (FA)-grafted chitosan (CS)-coated magnetic nanoparticle (MNP) with low toxicity, has been achieved. A chemotherapeutic drug such as doxorubicin (DOX), is loaded in the MNP-based matrix (FA-grafted CS-DOX-TPP-MNP), which is coated by an activated target tumor molecule of FA-grafted CS biopolymer with the inclusion of tripolyphosphate (TPP) as a linker...
April 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28403669/use-of-videoconferencing-for-physical-therapy-in-people-with-musculoskeletal-conditions-a-systematic-review
#9
Stacey Lovo Grona, Brenna Bath, Angela Busch, Thomas Rotter, Catherine Trask, Elizabeth Harrison
Background Physical therapists are key players in the management of musculoskeletal conditions, which are common in rural and remote communities. There are few physical therapists in rural regions compared to potential need, so care is either not provided or must be sought in urban centers, requiring travel and time away from work and family to access services. Telerehabilitation strategies, such as real-time videoconferencing, are emerging as possible solutions to address shortages in rural physical therapy services...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28399988/youth-social-behaviour-and-network-therapy-y-sbnt-adaptation-of-a-family-and-social-network-intervention-for-young-people-who-misuse-alcohol-and-drugs-a-randomised-controlled-feasibility-trial
#10
Judith Watson, Paul Toner, Ed Day, Donna Back, Louca-Mai Brady, Caroline Fairhurst, Charlotte Renwick, Lorna Templeton, Shabana Akhtar, Charlie Lloyd, Jinshuo Li, Kim Cocks, Sangeeta Ambegaokar, Steve Parrott, Paul McArdle, Eilish Gilvarry, Alex Copello
BACKGROUND: Family interventions appear to be effective at treating young people's substance misuse. However, implementation of family approaches in UK services is low. This study aimed to demonstrate the feasibility of recruiting young people to an intervention based on an adaptation of adult social behaviour and network therapy. It also sought to involve young people with experience of using substance misuse services in the research process. OBJECTIVES: To demonstrate the feasibility of recruiting young people to family and social network therapy and to explore ways in which young people with experience of using substance misuse services could be involved in a study of this nature...
March 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28391201/using-wearable-technology-to-generate-objective-parkinson-s-disease-dyskinesia-severity-score-possibilities-for-home-monitoring
#11
Mehdi Delrobaei, Navid Baktash, Greydon Gilmore, Kenneth McIsaac, Mandar Jog
A variety of clinical scales are available to assess dyskinesia severity in Parkinson's disease patients; however, such assessments are subjective, do not provide long term monitoring, and their use is subject to inter- and intra-rater variability. In this study, an objective dyskinesia score was developed using an IMU-based motion capture system. Deep brain stimulation (DBS) surgery is currently the only acute intervention that results in rapidly progressive reduction of dyskinesia's severity, hence this form of therapy was selected as a model to validate the proposed method...
April 3, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28389124/prevalence-and-risk-markers-of-early-psychological-distress-after-icd-implantation-in-the-european-remote-cied-study-cohort
#12
Henneke Versteeg, Ivy Timmermans, Mathias Meine, Edgar Zitron, Philippe Mabo, Johan Denollet
BACKGROUND: Evidence on psychological distress in patients living with an implantable cardioverter defibrillator (ICD) is inconclusive. The current study is the first to examine the prevalence and risk markers of anxiety and/or depression in a large international cohort of European ICD patients with or without cardiac resynchronization therapy (CRT). METHOD: Heart failure patients (N=569) from France, Germany, Spain, Switzerland and the Netherlands participating in the REMOTE-CIED study completed a set of questionnaires 1-2weeks post ICD-implantation, including the 7-item Generalized Anxiety Disorder scale and the 9-item Patient Health Questionnaire to assess anxiety and depressive symptoms, respectively...
March 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28387083/-european-society-of-cardiology-guidelines-for-the-management-of-chronic-heart-failure
#13
REVIEW
A Ancion, V D'Orio, P Lancellotti
Heart failure is a major public health problem in industrialized countries. Its prognosis remains poor. The new European recommendations for heart failure management allow validation of the latest advances in the field. This article focuses on the definition, classification and treatment of chronic heart failure. Indeed, there are new aspects to consider such as, a new classification, a new therapeutic class and new remote monitoring solutions. On the contrary, there is no change in initial drug therapy, integration of the patient in a multidisciplinary program and the importance of treatment of comorbidities...
February 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28386820/oral-teicoplanin-as-an-alternative-first-line-regimen-in-clostridium-difficile-infection-in-elderly-patients-a-case-series
#14
Benjamin Davido, Céline Leplay, Frédérique Bouchand, Aurélien Dinh, Maryvonne Villart, Jean-Laurent Le Quintrec, Laurent Teillet, Jérôme Salomon, Hugues Michelon
BACKGROUND: Elderly patients are more susceptible to Clostridium difficile infections (CDIs). Despite existing guidelines, there is no specific treatment for CDI in geriatrics. Vancomycin is commonly used in the treatment of CDI. Teicoplanin is an alternative glycopeptide which recently received marketing authorization approval for CDI in Europe. OBJECTIVES: Evaluate the potential interest of oral teicoplanin and assess whether such treatment could potentially become an alternative treatment in mild to severe CDIs in elderly patients...
April 6, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28383477/the-damage-control-surgery-in-austere-environments-research-group-dcsaerg-a-dynamic-program-to-facilitate-real-time-tele-mentoring-tele-diagnosis-to-address-exsanguination-in-extreme-and-austere-environments
#15
Andrew W Kirkpatrick, Jessica McKee, Paul B McBeth, Chad G Ball, Anthony LaPorta, Timothy Broderick, Tim Leslie, David King, Heather Wright-Beatty, Jocelyn Keillor, Homer Tien
Hemorrhage is the most preventable cause of post-traumatic death. Many cases are potentially anatomically salvageable, yet remain lethal without logistics or trained personnel to deliver diagnosis or Resuscitative-surgery in austere-environments. Revolutions in technology for remote-mentoring of ultrasound and surgery may enhance capabilities to utilize the skill-sets of non-physicians. Thus, our Research-Collaborative explored remote-mentoring to empower non-physicians to address junctional and torso hemorrhage-control in Austere-environments...
April 5, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28381115/remote-ischemic-conditioning-for-patients-with-stemi
#16
Michael Rahbek Schmidt, Mathis Ersted Rasmussen, Hans Erik Bøtker
ST-segment elevation myocardial infarction (STEMI) remains a leading cause of death and morbidity, despite declining incidence and improved short-term outcome in many countries. Although mortality declines in developed countries with easy and fast access to optimized treatment, development of heart failure often remains a challenge in survivors and still approaches 10% at 1 year. Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy frequently establish complete reperfusion and acutely stabilize the patient, but the reperfusion itself adds further to the damage in the myocardium compromising the long-term outcome...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28371289/prolonged-cold-ischemia-time-results-in-local-and-remote-organ-dysfunction-in-a-murine-model-of-vascularized-composite-transplantation
#17
Néha Datta, Sean G Devaney, Ronald W Busuttil, Kodi Azari, Jerzy W Kupiec-Weglinski
Vascularized composite allotransplantation (VCA) is a viable reconstructive option for complex tissue defects. Although grafts with large muscular component may be uniquely susceptible to ischemia/reperfusion (I/R) syndrome, the safe cold ischemia time in VCA has not been established. We investigated the effects of cold ischemia on innate immune response and recipient survival in a murine orthotopic hindlimb transplantation model. Surprisingly, mice receiving grafts exposed to 6h or longer of cold storage demonstrated reduced survival and massive elevations in serum creatinine, BUN and creatine kinase, as compared to 1h of cold storage recipients...
March 30, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28360491/remote-physiotherapy-monitoring-using-the-novel-d-r-therapy-iphone-application
#18
Abhishek Vaish, Saif Ahmed, Anan Shetty
BACKGROUND: Patient compliance to physiotherapy after surgical intervention is key to optimal functional outcome. This has been recognised by published literature over a number of decades. Improving and monitoring patient compliance remains a challenge. This paper explores the use of a website linked iPhone application that may be used to address this issue. PURPOSE: The purpose of this case study was to assess if the D+R Therapy application was of benefit to a patient and to assess the advantages and disadvantages of such a system...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28349771/antivenom-for-european-vipera-species-envenoming
#19
Thomas Lamb, Luc de Haro, Davide Lonati, Miran Brvar, Michael Eddleston
BACKGROUND: European viper bite is relatively uncommon but can cause serious envenoming, particularly swelling and hemorrhage spreading from limb to trunk that can cause long term disability. Systemic features are relatively mild compared to many other venomous species. Moderate-to-severe envenoming requires antivenom, which is given many hundreds of times each year across the continent. Several Vipera spp antivenoms are produced in Europe, but there is little comparative information available for the antivenoms and none is licensed with the European Medicines Agency...
March 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28347441/assessment-of-a-personalized-and-distributed-patient-guidance-system
#20
Mor Peleg, Yuval Shahar, Silvana Quaglini, Tom Broens, Roxana Budasu, Nick Fung, Adi Fux, Gema García-Sáez, Ayelet Goldstein, Arturo González-Ferrer, Hermie Hermens, M Elena Hernando, Val Jones, Guy Klebanov, Denis Klimov, Daniel Knoppel, Nekane Larburu, Carlos Marcos, Iñaki Martínez-Sarriegui, Carlo Napolitano, Àngels Pallàs, Angel Palomares, Enea Parimbelli, Belén Pons, Mercedes Rigla, Lucia Sacchi, Erez Shalom, Pnina Soffer, Boris van Schooten
OBJECTIVES: The MobiGuide project aimed to establish a ubiquitous, user-friendly, patient-centered mobile decision-support system for patients and for their care providers, based on the continuous application of clinical guidelines and on semantically integrated electronic health records. Patients would be empowered by the system, which would enable them to lead their normal daily lives in their regular environment, while feeling safe, because their health state would be continuously monitored using mobile sensors and self-reporting of symptoms...
May 2017: International Journal of Medical Informatics
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