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https://www.readbyqxmd.com/read/30514385/oncolytic-virus-immunotherapy-future-prospects-for-oncology
#1
REVIEW
Junaid Raja, Johannes M Ludwig, Scott N Gettinger, Kurt A Schalper, Hyun S Kim
BACKGROUND: Immunotherapy is at the forefront of modern oncologic care. Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerging class in both primary and salvage therapy is oncolytic viruses. This therapy offers a multimodal approach to specifically and effectively target and destroy malignant cells, though a barrier oncoviral therapies have faced is a limited therapeutic response to currently delivery techniques...
December 4, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/30488242/updates-in-heart-failure-30-day-readmission-prevention
#2
REVIEW
David Goldgrab, Kathir Balakumaran, Min Jung Kim, Sara R Tabtabai
Heart failure (HF) and HF 30-day readmission rates have been a major focus of efforts to reduce health care cost in the recent era. Since the implementation of the Affordable Care Act (ACA) in 2012 and the Hospital Readmission Reduction Program (HRRP), concerted efforts have focused on reduction of 30-day HF readmissions and other admission diagnoses targeted by the HRRP. Hospitals and organizations have instituted wide-ranging programs to reduce short-term readmissions, but the data supporting these programs is often mixed...
November 28, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/30480535/experience-managing-adult-patients-on-continuous-ambulatory-peritoneal-dialysis-in-bangladesh
#3
Sarwar Iqbal, M Masud Iqbal, Tufayel Ahmed Chowdhury, Md Abdur Rahim, Abu Sayed Muhammad Manzur Morshed Bhuiyan, Mehruba Alam Ananna, Md Ayub Ali Chowdhury, Rana Mokarram Hossain, Nurul Islam, Md Nurul Islam
Continuous ambulatory peritoneal dialysis (CAPD) is becoming increasingly known to the patients of Bangladesh, and patient numbers are increasing. Here, we report our experience and clinical outcomes in this field.Our analysis included all CAPD patients managed in a tertiary care hospital in Bangladesh between 2003 and 2015. All patients received a Tenckhoff double-cuff catheter by mini-laparotomy, and twin bags were used in most patients. In acute cases, regular exchanges were started manually with small-volume dwells the same or the next day...
November 2018: Advances in Peritoneal Dialysis
https://www.readbyqxmd.com/read/30478937/dream5-an-open-label-randomized-cross-over-study-to-evaluate-the-safety-and-efficacy-of-day-and-night-closed-loop-control-using-the-md-logic-automated-insulin-delivery-system-compared-to-sensor-augmented-pump-therapy-in-patients-with-type-1-diabetes-at-home
#4
Torben Biester, Judith Nir, Kerstin Remus, Alon Farfel, Ido Muller, Sarah Biester, Eran Atlas, Klemen Dovc, Natasa Bratina, Olga Kordonouri, Tadej Battelino, Moshe Philip, Thomas Danne, Revital Nimri
AIMS: Previous DREAM studies demonstrated the safety and efficacy of the CE marked MD-Logic closed-loop system (DreaMed GlucoSitter™) in different settings for overnight glycaemic control. The present study aims to evaluate the system for day and night use for 60 hours during weekend time at home compared to sensor-augmented pump (SAP) therapy in participants with type 1 diabetes. METHODS: This was a prospective, multicenter, crossover, controlled study. All participants were connected in randomized order for one weekend to SAP therapy or the MD-Logic System: in the intervention arm only the amount of carbohydrate was entered into the bolus calculator, the rest of insulin dosing was delivered automated and wirelessly by a tablet computer...
November 26, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30478809/evaluation-of-recurrent-ventricular-tachyarrhythmias-in-patients-who-survived-out-of-hospital-cardiac-arrest-due-to-ventricular-fibrillation-eligibility-for-subcutaneous-implantable-defibrillator-therapy
#5
Dominic A M J Theuns, Rohit E Bhagwandien, Tamas Szili-Torok, Felix Zijlstra, Sing-Chien Yap
PURPOSE: The subcutaneous implantable defibrillator (S-ICD) was developed to avoid complications related to transvenous leads. A trade-off with the S-ICD is the inability to deliver antitachycardia pacing (ATP). Data is scarce about the recurrence and characteristics of ventricular tachyarrhythmias (VTa) during a follow-up in survivors of out-of-hospital cardiac arrest due to ventricular fibrillation (OHCA-VF). The aim of the study is to determine the characteristics of VTa triggering ICD therapy in order to assess whether survivors of OHCA-VF are eligible candidates for the S-ICD...
November 26, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/30477089/effect-of-combined-treatment-of-ketorolac-and-remote-ischemic-preconditioning-on-renal-ischemia-reperfusion-injury-in-patients-undergoing-partial-nephrectomy-pilot-study
#6
Hae Keum Kil, Ji Young Kim, Young Deuk Choi, Hye Sun Lee, Tae Kwang Kim, Ji Eun Kim
We evaluated postoperative renal function in patients with/without combined therapy of ketorolac and remote ischemic preconditioning during partial nephrectomy. Sixteen patients were randomly allocated to either the ketorolac combined with RIPC group (KI, n = 8) or control group ( n = 8). The KI group received both remote ischemic preconditioning before surgery and intravenous ketorolac of 1 mg/kg before renal artery clamping. Renal parameters were measured before induction, after anesthesia induction, and 2, 12, 24, 48, and 72 h after renal artery declamping...
November 23, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30462208/atrial-fibrillation-burden-progression-and-the-risk-of-death-a-case-crossover-analysis-in-patients-with-cardiac-implantable-electronic-devices
#7
Jonathan P Piccini, Rod Passman, Mintu Turakhia, Allison T Connolly, Yelena Nabutovsky, Niraj Varma
Aims: Atrial fibrillation (AF) is associated with increased mortality, but the temporal relationship between AF burden (AFB) and death among patients with cardiac implanted electronic devices is unknown. We sought to characterize the timing and progression of AFB before death. Methods and results: Using Merlin.netTM remote monitoring (RM) data, we analysed weekly AFB in patients age ≥55 years implanted with dual-chamber pacemaker, implantable cardioverter-defibrillator, or cardiac resynchronization therapy devices whose death was verified in the Social Security Death Index and who had continuous RM from 1 year to 4 weeks preceding death...
November 19, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/30459146/using-video-technology-to-increase-treatment-completion-for-patients-with-latent-tuberculosis-infection-on-3-month-isoniazid-and-rifapentine-an-implementation-study
#8
Chee Kin Lam, Kara McGinnis Pilote, Ashraful Haque, Joseph Burzynski, Christine Chuck, Michelle Macaraig
BACKGROUND: Since January 2013, the New York City (NYC) Health Department Tuberculosis (TB) Program has offered persons diagnosed with latent TB infection (LTBI) the 3-month, once-weekly isoniazid and rifapentine (3HP) treatment regimen. Patients on this treatment are monitored in-person under directly observed therapy (DOT). To address patient and provider barriers to in-person DOT, we piloted the use of a videoconferencing software app to remotely conduct synchronous DOT (video directly observed therapy; VDOT) for patients on 3HP...
November 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30457255/medicare-and-medicaid-programs-cy-2019-home-health-prospective-payment-system-rate-update-and-cy-2020-case-mix-adjustment-methodology-refinements-home-health-value-based-purchasing-model-home-health-quality-reporting-requirements-home-infusion-therapy-requirements
#9
(no author information available yet)
This final rule with comment period updates the home health prospective payment system (HH PPS) payment rates, including the national, standardized 60-day episode payment rates, the national per- visit rates, and the non-routine medical supply (NRS) conversion factor, effective for home health episodes of care ending on or after January 1, 2019. This rule also: Updates the HH PPS case-mix weights for calendar year (CY) 2019 using the most current, complete data available at the time of rulemaking; discusses our efforts to monitor the potential impacts of the rebasing adjustments that were implemented in CYs 2014 through 2017; finalizes a rebasing of the HH market basket (which includes a decrease in the labor-related share); finalizes the methodology used to determine rural add-on payments for CYs 2019 through 2022, as required by section 50208 of the Bipartisan Budget Act of 2018 (Pub...
November 13, 2018: Federal Register
https://www.readbyqxmd.com/read/30452784/safety-and-tolerability-of-the-chymase-inhibitor-fulacimstat-in-patients-with-left-ventricular-dysfunction-after-myocardial-infarction-results-of-the-chiara-mia-1-trial
#10
Hans-Dirk Düngen, Lars Kober, Savina Nodari, Morten Schou, Christiane Otto, Michael Becka, Friederike Kanefendt, Bernhard R Winkelmann, Gunnar Gislason, Frank Richard, Olav Wendelboe Nielsen, Mihai Gheorghiade, Michele Senni
The chymase inhibitor fulacimstat is developed as a first-in-class treatment option for the inhibition of adverse cardiac remodeling in patients with left ventricular dysfunction (LVD) after acute myocardial infarction (MI). The aim of the study was to examine the safety and tolerability of fulacimstat in patients with LVD after remote MI. A multicenter, multinational randomized, placebo-controlled study was performed in clinically stable patients (40-79 years of age, left ventricular ejection fraction ≤ 45% because of MI in medical history) who were on stable evidence-based standard-of-care therapies for LVD post-MI including an angiotensin converting enzyme inhibitor or angiotensin receptor blocker at doses of at least half the recommended target dose...
November 19, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/30452705/web-based-contingency-management-for-adolescent-tobacco-smokers-a-clinical-trial
#11
Arit Harvanko, Stacey Slone, Brent Shelton, Jesse Dallery, Sherecce Fields, Brady Reynolds
Introduction: Adolescence is a critical time when the majority of tobacco users initiate smoking. Contingency management for adolescent smoking cessation has shown promise in previous studies, but efficacy following removal of contingencies is not well understood. The current study examined a remote form of contingency management among non-treatment seeking adolescent smokers. Methods: Participants (N=127) submitted breath carbon monoxide (CO) thrice daily throughout a 42-day program...
November 18, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/30451815/high-correlation-between-achieved-and-expected-distraction-using-magnetically-controlled-growth-rods-mcgr-with-rib-to-pelvis-fixation-in-pediatric-spine-deformity
#12
Heiko M Lorenz, Lena Braunschweig, Batoul Badwan, Katharina Groenefeld, Marina M Hecker, Konstantinos Tsaknakis, Jasmin Grote, Anna K Hell
PURPOSE: Magnetically controlled implant systems have been established to treat severe progressive spinal deformity in children. The purpose of this study was to evaluate (1) the ratio between achieved and expected distraction length, (2) the complication rate and its risk factors as well as (3) the correlation of the distraction length and the length of the spine. METHODS: A total of 40 patients with an average follow-up of 34 (14 to 57) months were prospectively included in the study...
November 16, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/30445700/a-graded-multifunctional-hybrid-scaffold-with-superparamagnetic-ability-for-periodontal-regeneration
#13
Simone Sprio, Elisabetta Campodoni, Monica Sandri, Lorenzo Preti, Tobias Keppler, Frank A Müller, Nicola M Pugno, Anna Tampieri
The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different mineralized and non-mineralized dental tissues. In this respect, the present work develops a novel multifunctional hybrid scaffold recapitulating the different features of alveolar bone, periodontal ligament, and cementum by integrating the biomineralization process, and tape casting and electrospinning techniques...
November 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30443279/remote-monitoring-of-implantable-cardioverter-defibrillators-cardiac-resynchronization-therapy-and-permanent-pacemakers-a-health-technology-assessment
#14
(no author information available yet)
Background: Under usual care, people with an implantable cardioverter-defibrillator (ICD), cardiac resynchronization therapy with or without a defibrillator (CRT-D and CRT-P, respectively), or a permanent pacemaker have follow-up in-person clinic visits. Remote monitoring of these devices allows the transfer of the information stored in the device so that it can be accessed by the clinic personnel via a secured website. Methods: We completed a health technology assessment, which included an evaluation of clinical benefits and harms, value for money, and patient preferences for remote monitoring of ICDs, CRTs, and permanent pacemakers plus clinic visits compared with clinic visits alone...
2018: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/30439443/intracranial-atherosclerotic-disease
#15
Yuan Wang, Ran Meng, Gang Liu, Catherine Cao, Fenghua Chen, Kunlin Jin, Xunming Ji, Guodong Cao
Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging...
November 12, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/30430823/fe3-induced-synchronous-formation-of-composite-hydrogels-for-effective-synergistic-tumor-therapy-in-nir-i-ii-biowindows
#16
Jiulong Zhao, Chunhua Zhou, Chenyao Wu, Huan Wu, Chunping Zhu, Changqing Ye, Shige Wang, Duowu Zou
Alginate-Ca2+ hydrogel has been used to immobilize photothermal materials as well as chemotherapy drugs at lesion sites to prevent their entry into the bloodstream. However, the alginate-Ca2+ gelation mechanism may result in hardening of the blood vessels due to Ca2+ migration to the lesion site. In this study, a unique and facile one-pot formation of chemotherapeutic (doxorubicin, DOX) and polypyrrole (PPy)-containing alginate hydrogel was designed by introducing Fe3+, which can synchronously induce the polymerization of pyrrole and gelatinization of alginate, into the DOX/pyrrole/alginate solution...
November 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30428863/protocol-for-evaluating-the-effects-of-a-foot-ankle-therapeutic-exercise-program-on-daily-activity-foot-ankle-functionality-and-biomechanics-in-people-with-diabetic-polyneuropathy-a-randomized-controlled-trial
#17
Renan L Monteiro, Cristina D Sartor, Jane S S P Ferreira, Milla G B Dantas, Sicco A Bus, Isabel C N Sacco
BACKGROUND: Diabetic polyneuropathy (DPN) negatively affects foot and ankle function (strength and flexibility), which itself affects the daily physical activity and quality of life of patients. A physical therapy protocol aiming to strengthen the intrinsic and extrinsic foot muscles and increase flexibility may be a promising approach to improve lower-extremity function, prevent further complications, and improve autonomy for daily living activities in these patients. Thus, the inclusion of a specific foot-related exercises focused on the main musculoskeletal impairments may have additional effects to the conventional interventions in the diabetic foot...
November 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30425769/radiation-induced-insufficiency-fracture-of-the-femur-18-years-after-radiation-therapy
#18
Francis G Celii, Nicholas M Beckmann
Advances in oncologic treatment have improved survival rates, allowing late effects of radiotherapy to become more prevalent. Our patient, an 82-year-old woman with a remote history of right thigh basal cell carcinoma treated with resection and radiation therapy 18 years prior, presented with severe right thigh pain and inability to bear weight as she had suffered a femur fracture after a fall from standing. Initial imaging was suspicious for pathologic fracture secondary to malignancy due to imaging findings and because radiation-induced fractures have rarely been reported beyond 44 months from treatment...
February 2019: Radiology Case Reports
https://www.readbyqxmd.com/read/30423822/co-administered-polymeric-nano-antidotes-for-improved-photo-triggered-response-in-glioblastoma
#19
Janel Kydd, Rahul Jadia, Prakash Rai
Polymer-based nanoparticles (NPs) are useful vehicles in treating glioblastoma because of their favorable characteristics such as small size and ability to cross the blood⁻brain barrier, as well as reduced immunogenicity and side effects. The use of a photosensitizer drug such as Verteporfin (BPD), in combination with a pan-vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI), Cediranib (CED), encapsulated in NPs will provide the medical field with new research on the possible ways to treat glioblastoma...
November 10, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/30419306/rapid-multi-site-remote-surface-dosimetry-for-total-skin-electron-therapy-scintillator-target-imaging
#20
Irwin Tendler, Petr Brůža, Jacqueline Andreozzi, Michael Jermyn, Benjamin Williams, Lesley Jarvis, Brian Pogue, David Gladstone
PURPOSE: The goal of this work is to produce a surface dosimetry method capable of accurately and remotely measuring skin dose for patients undergoing total skin electron therapy (TSET) without the need for post-exposure dosimeter processing. A rapid and wireless surface dosimetry system was developed to improve clinical workflow. Scintillator surface dosimetry was conducted on patients undergoing TSET by imaging scintillator targets with an intensified camera during TSET delivery. METHODS: & Materials: Disc-shaped scintillator targets were attached to the skin surface of patients undergoing TSET and imaged with an intensified, time-gated, and linac-synchronized camera...
November 9, 2018: International Journal of Radiation Oncology, Biology, Physics
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