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https://www.readbyqxmd.com/read/29676061/use-of-fragmented-qrs-in-prognosticating-clinical-deterioration-and-mortality-in-pulmonary-embolism-a-meta-analysis
#1
REVIEW
Amro Qaddoura, Geneviève C Digby, Conrad Kabali, Piotr Kukla, Gary Tse, Benedict Glover, Adrian M Baranchuk
BACKGROUND: Fragmented QRS (fQRS) on electrocardiography is potentially valuable in prognosticating acute pulmonary embolism (PE). ECG is one of the first tests performed in the emergency department, quickly interpretable, noninvasive, inexpensive, and available in remote areas. We aimed to review fQRS's role in PE prognostication. METHODS: We searched MEDLINE, EMBASE, Google Scholar, Web of Science, abstracts, conference proceedings, and reference lists until October 2017...
April 19, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29675269/translation-of-remote-control-regenerative-technologies-for-bone-repair
#2
Hareklea Markides, Jane S McLaren, Neil D Telling, Noura Alom, E'atelaf A Al-Mutheffer, Richard O C Oreffo, Andrew Zannettino, Brigitte E Scammell, Lisa J White, Alicia J El Haj
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of in vitro bone tissue engineering strategies and provides an effective means of controlling cell behaviour towards therapeutic outcomes. However, the delivery of mechanical stimuli to exogenous MSC populations, post implantation, poses a significant translational hurdle...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29665830/implementation-of-telemedicine-for-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#3
Zhengping Huang, Xia Pan, Weiming Deng, Zhixiang Huang, Yukai Huang, Xuechan Huang, Zhaohua Zhu, Weiyu Han, Shaoling Zheng, Xin Guo, Changhai Ding, Tianwang Li
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies have revealed that patients with OA benefitted from enhanced management via telemedicine. Guangdong Online Hospital (GOH) is the first officially recognized web-based hospital that provides telemedicine service in China...
April 17, 2018: Trials
https://www.readbyqxmd.com/read/29663695/a-magnetically-responsive-biomaterial-system-for-flexibly-regulating-the-duration-between-pro-and-anti-inflammatory-cytokine-deliveries
#4
Anita E Tolouei, Nihan Dülger, Rosa Ghatee, Stephen Kennedy
While inflammation can be problematic, it is nonetheless necessary for proper tissue regeneration. However, it remains unclear how the magnitude and duration of the inflammatory response impacts regenerative outcome. This is partially due to the difficulty in temporally regulating macrophage phenotype at wound sites. Here, a magnetically responsive biomaterial system potentially capable of temporally regulating macrophage phenotypes through sequential, on-demand cytokine deliveries is presented. This material system is designed to (i) rapidly recruit proinflammatory macrophages (M1) through initial cytokine deliveries and (ii) subsequently transition macrophages toward anti-inflammatory phenotypes (M2s) through delayed, magnetically triggered cytokine release...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29660212/aiming-for-elimination-outcomes-of-a-consultation-pathway-supporting-regional-general-practitioners-to-prescribe-direct-acting-antiviral-therapy-for-hepatitis-c
#5
A J Wade, A McCormack, C Roder, K McDonald, M Davies, N Scott, M Wardrop, E Athan, M E Hellard
To increase access to treatment, the Australian government enabled general practitioners (GPs) to prescribe direct-acting antivirals (DAA) to treat hepatitis C virus (HCV) - in consultation with a specialist if inexperienced in HCV management. This study describes the establishment and outcomes of a remote consultation pathway supporting GPs to treat HCV. Key stakeholders from primary and tertiary healthcare services in the Barwon South Western region developed and implemented an HCV remote consultation pathway...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29652309/-dynamics-of-clinical-and-biological-indices-of-the-asthenic-symptom-complex-during-immunotropic-therapy-of-patients-with-schizophrenia
#6
A V Yakimets, S A Zozulya, I V Oleichik, T P Klyushnik
AIM: To identify clinical, psychopathological, and immunological features of the asthenic symptom-complex in patients with schizophrenia and to analyze the possibility of optimizing complex therapy of these conditions using the immunotropic drug bestim. MATERIAL AND METHODS: Forty-three male patients, aged 20-55 years, were examined. Clinical examination of patients (PANSS, MFI-20) was performed before, and 5, 30 days after the end of treatment. The activity of inflammatory markers (leukocyte elastase (LE) and a1-proteinase inhibitor (a1-PI)) was determined in blood serum...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29651771/remote-brain-microhaemorrhages-may-predict-haematoma-in-glioma-patients-treated-with-radiation-therapy
#7
Augustin Lecler, Frédérique Charbonneau, Dimitri Psimaras, Marie-Astrid Metten, Antoine Gueguen, Khe Hoang Xuan, Loic Feuvret, Julien Savatovsky
OBJECTIVES: To evaluate the prevalence of cerebral remote microhaemorrhages (RMH) and remote haematomas (RH) using magnetic resonance susceptibility-weighted imaging (SWI) among patients treated for gliomas during follow-up. METHODS: We conducted a retrospective single centre longitudinal study on 58 consecutive patients treated for gliomas from January 2009 through December 2010. Our institutional review board approved this study. We evaluated the presence and number of RMH and RH found outside the brain tumour on follow-up MR imaging...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29642874/pilot-evaluation-of-a-second-generation-electronic-pill-box-for-adherence-to-bedaquiline-and-antiretroviral-therapy-in-drug-resistant-tb-hiv-co-infected-patients-in-kwazulu-natal-south-africa
#8
N Bionghi, A Daftary, B Maharaj, Z Msibi, K R Amico, G Friedland, C Orrell, N Padayatchi, M R O'Donnell
BACKGROUND: The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and derive sustained benefit. Real-time electronic dose monitoring (EDM) accurately measures adherence and allows for titration of adherence support for anti-retroviral therapy (ART). The goal of this study was to evaluate the accuracy and acceptability of a next-generation electronic pillbox (Wisepill RT2000) for Bedaquiline-containing TB regimens...
April 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29629697/rapid-diagnostic-tests-in-childhood-infections
#9
Ritabrata Kundu
Presumptive treatment of infections often results in irrational antimicrobial use resulting in detrimental spread of drug resistance and untoward side effects. A rapid diagnostic test (RDT) is a test that delivers a result earlier than conventional testing methods employed in the past to identify the offending microorganism. RDTs help in early definitive therapy, reduction in hospital stay and cost, and in degree of morbidity and mortality associated with the infection. To select a proper RDT, one should consider how specific and sensitive the test is...
March 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29623858/cognitive-rehabilitation-of-cerebellar-deficits
#10
Hiroshi Mitoma, Peter Marien, Kim van Dun, Frank Van Overwalle, Mario Manto
During the past 3 decades numerous neurophysiological, neuroimaging, experimental and clinical studies have evidenced a crucial role for the cerebellum in cognitive, affective and behavioral functions. As a result of the acknowledged modulatory role of the cerebellum upon remote structures such as the cerebral cortex, cerebellar injury may give rise to a constellation of behavioral, affective and cognitive symptoms (Schmahmann's Syndrome). In sharp contrast to the wide range of therapeutic interventions to treat cognitive and affective disorders following cerebral cortical lesions and despite the consequences of Schmahmann's syndrome upon daily life activities, the literature is surprisingly only scantly documented with studies investigating the impact of cognitive therapies on cerebellar induced cognitive and affective disorders...
April 3, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29615448/a-protocol-for-a-prospective-observational-study-using-chest-and-thumb-ecg-transient-ecg-assessment-in-stroke-evaluation-tease-in-sweden
#11
Peter Magnusson, Hirsh Koyi, Gustav Mattsson
INTRODUCTION: Atrial fibrillation (AF) causes ischaemic stroke and based on risk factor evaluation warrants anticoagulation therapy. In stroke survivors, AF is typically detected with short-term ECG monitoring in the stroke unit. Prolonged continuous ECG monitoring requires substantial resources while insertable cardiac monitors are invasive and costly. Chest and thumb ECG could provide an alternative for AF detection poststroke.The primary objective of our study is to assess the incidence of newly diagnosed AF during 28 days of chest and thumb ECG monitoring in cryptogenic stroke...
April 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29615445/piloting-the-addition-of-contingency-management-to-best-practice-counselling-as-an-adjunct-treatment-for-rural-and-remote-disordered-gamblers-study-protocol
#12
Darren R Christensen, Chad S G Witcher, Trent Leighton, Rebecca Hudson-Breen, Samuel Ofori-Dei
INTRODUCTION: Problematic gambling is a significant Canadian public health concern that causes harm to the gambler, their families, and society. However, a significant minority of gambling treatment seekers drop out prior to the issue being resolved; those with higher impulsivity scores have the highest drop-out rates. Consequently, retention is a major concern for treatment providers. The aim of this study is to investigate the efficacy of internet-delivered cognitive behavioural therapy (CBT) and internet-delivered CBT and contingency management (CM+) as treatments for gambling disorder in rural Albertan populations...
April 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29611503/accuracy-of-the-lee-white-clotting-time-performed-in-the-hospital-routine-to-detect-coagulopathy-in-bothrops-atrox-envenomation
#13
Jose Diego de Brito Sousa, Jacqueline Almeida Gonçalves Sachett, Sâmella Santos Oliveira, Iran Mendonça-da-Silva, Hedylamar Oliveira Marques, Marcus Vinicius Guimarães de Lacerda, Hui Wen Fan, Wuelton Marcelo Monteiro
Snake envenomation is a major public health problem in Brazil. Systemic complications that may arise from snakebites are mainly related to coagulopathy. The Lee-White clotting time (LWCT) is a simple and inexpensive test and available even in remote health facilities. However, the diagnostic value of such test needs to be evaluated to accurately diagnose coagulopathy in the clinical practice. This study aimed to assess the reliability of the LWCT performed in hospital routine to diagnose venom-induced coagulopathy...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29606148/telerehabilitation-for-aphasia-protocol-of-a-pragmatic-exploratory-pilot-randomized-controlled-trial
#14
Hege Prag Øra, Melanie Kirmess, Marian C Brady, Ingvild Elisabeth Winsnes, Silje Merethe Hansen, Frank Becker
BACKGROUND: The Cochrane review on the effectiveness of speech and language therapy for aphasia following stroke suggests intensity of therapy is a key predictor for outcome. Current aphasia services cannot provide intervention at the intensity observed within trial contexts because of resource limitations. Telerehabilitation could widen access to speech-language pathologists (SLPs) in geographically remote contexts and reduce the time spent on travel by the therapist and patient. The current academic literature within this field is in its infancy, with few trials of speech and language therapy (SLT) delivered by videoconference...
April 2, 2018: Trials
https://www.readbyqxmd.com/read/29598924/oncentra-brachytherapy-planning-system
#15
REVIEW
Jack Yang
In modern cancer management, treatment planning has progressed as a contemporary tool with all the advances in computing power in recent years. One of the advanced planning tools uses 3-dimensional (3D) data sets for accurate dose distributions in patient prescription. Among these planning processes, brachytherapy has been a very important part of a successful cancer management program, offering clinical benefits with specific or combined treatments with external beam therapy. In this chapter, we mainly discussed the Elekta Oncentra planning system, which is the main treatment planning tool for high-dose rate (HDR) modality in our facility and in many other facilities in the United States...
March 27, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29596906/atrial-electrogram-quality-in-single-pass-defibrillator-leads-with-floating-atrial-bipole-in-patients-with-permanent-atrial-fibrillation-and-cardiac-resynchronization-therapy
#16
Christian Sticherling, Dirk Müller, Beat A Schaer, Silke Krüger, Christof Kolb
Many patients receiving cardiac resynchronization therapy (CRT) suffer from permanent atrial fibrillation (AF). Knowledge of the atrial rhythm is important to direct pharmacological or interventional treatment as well as maintaining AV-synchronous biventricular pacing if sinus rhythm can be restored. A single pass single-coil defibrillator lead with a floating atrial bipole has been shown to obtain reliable information about the atrial rhythm but has never been employed in a CRT-system. The purpose of this study was to assess the feasibility of implanting a single coil right ventricular ICD lead with a floating atrial bipole and the signal quality of atrial electrograms (AEGM) in CRT-defibrillator recipients with permanent AF...
March 26, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29595537/chronic-osteomyelitis-caused-by-haemophilus-parainfluenzae-a-case-report
#17
Vignesh Ramachandran, Lee S Haruno, Theodora S Browne, Laila E Woc-Colburn, Scott B Rosenfeld, Vinitha R Shenava
CASE: A 14-year-old boy presented with a pathologic fracture of the distal aspect of the tibia and a remote history of a dog bite near the injury site. Imaging studies, biopsy, and presentation corroborated the diagnosis of chronic osteomyelitis. Multiple diagnostic methods were negative until an open biopsy identified Haemophilus parainfluenzae, a fastidious oropharyngeal bacterium, with polymerase chain reaction analysis. The patient underwent extensive debridement, placement of external fixation, and a year-long antibiotic therapy regimen...
January 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/29588437/time-gated-scintillator-imaging-for-real-time-optical-surface-dosimetry-in-total-skin-electron-therapy
#18
Petr Bruza, Sarah L Gollub, Jacqueline M Andreozzi, Irwin I Tendler, Benjamin B Williams, Lesley A Jarvis, David J Gladstone, Brian W Pogue
To measure surface dose by remote time-gated imaging of plastic scintillators.
 
 Methods: A novel technique for time-gated, intensified camera imaging of scintillator emission was demonstrated, and key parameters influencing the signal were analyzed, including distance, angle and thickness. A set of scintillator samples was calibrated by using thermo-luminescence detector response as reference. Examples of use in total skin electron therapy are described.
 
 Results: The data showed excellent room light rejection (signal-to-noise ratio of scintillation SNR ≈ 470), ideal scintillation dose response linearity, and 2% dose rate error...
March 28, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29584605/evaluating-the-impact-of-a-patient-centered-remote-monitoring-program-on-adherence-to-negative-pressure-wound-therapy
#19
Leah Griffin, Laura Leyva Casillas
A remote therapy monitoring (RTM) system has been developed for use with a negative pressure wound therapy (NPWT) unit for patients in the home care setting. In conjunction with RTM, a network of trained professionals call patients when their NPWT usage is low and provide education to assist with therapy adherence. OBJECTIVE: The objective of this evaluation is to examine the relationship between the RTM system and patient adherence. MATERIALS AND METHODS: One hundred ninety-eight home care patients receiving NPWT with RTM between December 2016 and April 2017 were included...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29582363/electrophysiological-characteristics-and-radiofrequency-ablation-of-sustained-monomorphic-ventricular-tachycardia-in-adult-patients-with-isolated-ventricular-noncompaction
#20
Yanhui Li, Yumei Xue, Jianhua Yu, Chenyang Jiang, Zulu Wang, Mackenzi Mbai, Venkatakrishna Tholakanahalli, David G Benditt, Jian-Ming Li
PURPOSE: This study examined electrophysiological characteristics and outcomes of patients with sustained ventricular tachycardia (VT) in the setting of isolated ventricular noncompaction (IVNC). BACKGROUND: In patients with IVNC, VT has been associated with sudden cardiac death. However, the electrophysiological characteristics and optimal management of these VTs are only incompletely understood. METHODS: This retrospective cohort study assessed arrhythmia characteristics and outcomes in IVNC patients with sustained monomorphic VTs...
March 26, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
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