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https://www.readbyqxmd.com/read/30099222/metabolic-features-and-regulation-of-the-healing-cycle-a-new-model-for-chronic-disease-pathogenesis-and-treatment
#1
Robert K Naviaux
Without healing, multicellular life on Earth would not exist. Without healing, one injury predisposes to another, leading to disability, chronic disease, accelerated aging, and death. Over 50% of adults and 30% of children and teens in the United States now live with a chronic illness. Advances in mass spectrometry and metabolomics have given scientists a new lens for studying health and disease. This study defines the healing cycle in metabolic terms and reframes the pathophysiology of chronic illness as the result of metabolic signaling abnormalities that block healing and cause the normal stages of the cell danger response (CDR) to persist abnormally...
August 9, 2018: Mitochondrion
https://www.readbyqxmd.com/read/30096261/heart-transplant-recipients-prefer-a-telemental-health-cognitive-behavioral-therapy-intervention-delivered-by-telephone
#2
Flavio Rose Epstein, Chi-Mei Liu, Janet Marie Stevenson
BACKGROUND: Depression and anxiety are common after heart transplant, and in a regional heart transplant center servicing northern California, willingness to participate in treatment can be a major barrier. INTRODUCTION: Our primary aim is to design a remote cognitive-behavioral therapy (CBT) intervention. This study is the first step in the process. Through a survey to the cohort of heart transplant recipients (N = 230), managed within the Kaiser Permanente Northern California's Heart Transplant Service, we aimed to assess symptoms of stress, depression, and anxiety, patient willingness to participate in a CBT intervention, and preference between video and telephone...
August 10, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/30094114/gastrointestinal-bleed-from-erosive-gastritis-and-duodenitis-a-sentinel-event-of-invasive-lobular-carcinoma-of-the-breast-and-a-diagnostic-dilemma
#3
Mark Bilinyi Ulanja, Mohamed Taha, Arshad Al-Mashhadani, Bryce D Beutler, Marwah Al-Tekreeti, Christie Elliot, Santhosh Ambika
Metastasis from breast cancer to the gastrointestinal (GI) tract is uncommon, and such events presenting as GI bleeding are exceedingly rare. In some individuals, the absence of classical findings of primary breast cancer coupled with the non-specific nature of GI symptoms may make early detection and diagnosis challenging. Our patient is a 75-year-old female who presented with symptomatic anemia manifesting as progressive dizziness, weakness, and early satiety that developed eight days after right knee arthroplasty...
June 7, 2018: Curēus
https://www.readbyqxmd.com/read/30093372/using-mobile-apps-to-assess-and-treat-depression-in-hispanic-and-latino-populations-fully-remote-randomized-clinical-trial
#4
Abhishek Pratap, Brenna N Renn, Joshua Volponi, Sean D Mooney, Adam Gazzaley, Patricia A Arean, Joaquin A Anguera
BACKGROUND: Most people with mental health disorders fail to receive timely access to adequate care. US Hispanic/Latino individuals are particularly underrepresented in mental health care and are historically a very difficult population to recruit into clinical trials; however, they have increasing access to mobile technology, with over 75% owning a smartphone. This technology has the potential to overcome known barriers to accessing and utilizing traditional assessment and treatment approaches...
August 9, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30092892/remotely-controlled-mandibular-positioning-during-drug-induced-sleep-endoscopy-toward-mandibular-advancement-device-therapy-feasibility-and-protocol
#5
Chloé Kastoer, Marijke Dieltjens, Sara Op de Beeck, Marc J Braem, Paul H Van de Heyning, Olivier M Vanderveken
STUDY OBJECTIVES: The potential of a remotely controlled mandibular positioner (RCMP) during sleep studies in individual patients suffering from obstructive sleep apnea (OSA) for the determination of the effective target protrusive position (ETPP) of the mandible has been demonstrated. The research goal of this study was to assess the feasibility of the application of RCMP during drug-induced sleep endoscopy (DISE) for the determination of ETPP. METHODS: Ten patients in whom OSA was diagnosed (50% male; age 54 ± 9...
August 6, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/30091136/outcomes-in-patients-undergoing-cardiac-resynchronization-therapy-complicated-by-device-related-infective-endocarditis
#6
Ewa Jędrzejczyk-Patej, Michał Mazurek, Oskar Kowalski, Adam Sokal, Karolina Adamczyk, Stanisław Morawski, Mariola Szulik, Tomasz Podolecki, Magdalena Sawicka, Zbigniew Kalarus, Radosław Lenarczyk
BACKGROUND: Cardiac device-related infective endocarditis (CDRIE) is one of the most serious complications of cardiac resynchronization therapy (CRT). AIM: The aim of the study was to assess clinical outcomes and their determinants in CRT patients with CDRIE. METHODS: Tertiary cardiology centre database was screened to identify all CDRIE cases, based on modified Duke criteria, amongst 765 consecutive CRT implantations between 2002 and 2015 (70...
August 9, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/30089607/therapist-assisted-internet-based-cognitive-behavioral-therapy-versus-progressive-relaxation-in-obsessive-compulsive-disorder-randomized-controlled-trial
#7
Michael Kyrios, Claire Ahern, Daniel B Fassnacht, Maja Nedeljkovic, Richard Moulding, Denny Meyer
BACKGROUND: Obsessive-compulsive disorder (OCD) is a highly disabling psychological disorder with a chronic course if left untreated. Cognitive behavioral therapy (CBT) has been shown to be an effective treatment, but access to face-to-face CBT is not always possible. Internet-based CBT (iCBT) has become an increasingly viable option. However, no study has compared iCBT to an analogous control condition using a randomized controlled trial (RCT). OBJECTIVE: A 2-armed RCT was used to compare a therapist-assisted 12-module iCBT to an analogous active attention control condition (therapist-assisted internet-based standard progressive relaxation training, iPRT) in adult OCD...
August 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30083309/near-infrared-laser-mediated-drug-release-and-antibacterial-activity-of-gold-nanorod-sputtered-titania-nanotubes
#8
Kyoung-Suk Moon, Young-Bum Park, Ji-Myung Bae, Seunghan Oh
The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod-sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline release and resulting antibacterial effects of gold nanorod-sputtered titania nanotubes using near-infrared laser irradiation. Gold nanorods prepared by ion plasma sputtering (aspect ratio = 1:3) showed optical properties like those of chemically synthesized gold nanorods, exhibiting photothermal effects in the near-infrared region, as demonstrated using field-emission scanning electron microscopy, transmission electron microscopy, and diffuse ultraviolet-visible-near-infrared spectrophotometry...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/30082061/using-technology-to-inform-and-deliver-precise-personalized-care-to-patients-with-end-stage-kidney-disease
#9
REVIEW
Len Usvyat, Lorien S Dalrymple, Franklin W Maddux
Consistent with the increase of precision medicine, the care of patients with end-stage kidney disease (ESKD) requiring maintenance dialysis therapy should evolve to become more personalized. Precise and personalized care is nuanced and informed by a number of factors including an individual's needs and preferences, disease progression, and response to and tolerance of treatments. Technology can support the delivery of more precise and personalized care through multiple mechanisms, including more accurate and real-time assessments of key care elements, enhanced treatment monitoring, and remote monitoring of home dialysis therapies...
July 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/30078058/evolution-of-clinical-trials-in-inflammatory-bowel-diseases
#10
REVIEW
Siddharth Singh
PURPOSE OF REVIEW: Since the first clinical trial of cortisone in ulcerative colitis in 1955, remarkable progress has been made in the design and conduct of clinical trials in inflammatory bowel diseases (IBD). In this review article, we will discuss evolution of clinical trials in IBD over the last 3-5 years. RECENT FINDINGS: Recognizing limitations intrinsic to clinical disease activity indices in IBD, regulatory authorities have recommended evaluating co-primary endpoints of patient-reported outcomes and endoscopic disease activity in clinical trials...
August 4, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/30077836/ionic-gradient-liposomes-recent-advances-in-the-stable-entrapment-and-prolonged-released-of-local-anesthetics-and-anticancer-drugs
#11
REVIEW
Munazza Tamkeen Fatima, Zeyaul Islam, Ejaj Ahmad, George E Barreto, Ghulam Md Ashraf
Liposomes have established themselves as great pharmaceutical carriers over the past three decades. These phospholipid vesicular systems have undergone great technical advances including remote drug loading, targeted delivery, and combinatorial drug therapy. Ionic gradient liposomes (IGL) necessitates active loading of the drug in preformed vesicles exhibiting a transmembrane pH or ion gradient, with a low intra liposome pH (∼ 4-5), and a high outside pH (∼7-8). It allows high drug encapsulation and prolonged release, particularly for amphipathic weak acids and weak bases...
August 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30074381/multimodal-biophotonics-of-semiconducting-polymer-nanoparticles
#12
Yuyan Jiang, Kanyi Pu
Biophotonics as an interdisciplinary frontier plays an increasingly important role in modern biomedical science. Optical agents are generally involved in biophotonics to interpret biomolecular events into readable optical signals for imaging and diagnosis or to convert photons into other forms of energy (such as heat, mechanical force, or chemical radicals) for therapeutic intervention and biological stimulation. Development of new optical agents including metallic nanoparticles, quantum dots, up-conversion nanoparticles, carbon dots, and silica nanoparticles has contributed to the advancement of this field...
August 3, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30071807/air-mobile-stroke-unit-for-access-to-stroke-treatment-in-rural-regions
#13
Silke Walter, Henry Zhao, Damien Easton, Cees Bil, Jonas Sauer, Yang Liu, Martin Lesmeister, Iris Q Grunwald, Geoffrey A Donnan, Stephen M Davis, Klaus Fassbender
Background In recent years, important progress has been made in effective stroke treatment, however, patients living in rural and remote areas have nil or very limited access to timely reperfusion therapies. Aims Novel systems of care to overcome the detrimental treatment gap for stroke patients living in rural and remote regions need to be developed. Summary of review A possible solution to the treatment disparity between stroke patients living in metropolitan and rural areas may involve the use of specially designed aircrafts equipped with the ability to diagnose and treat acute stroke at remote emergency sites...
August 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30067082/the-potential-role-of-lsd1-inhibitors-in-the-treatment-of-sickle-cell-disease-a-review-of-preclinical-animal-model-data
#14
Angela Rivers, Ramasamy Jagadeeswaran, Donald Lavelle
Sickle cell disease (SCD) is caused by a mutation of the b-globin gene(21) that triggers the polymerization of deoxygenated sickle hemoglobin (HbS). Approximately 100,000 SCD patients in the U.S. and millions worldwide(53) suffer from chronic hemolytic anemia, painful crises, multisystem organ damage, and reduced life expectancy(60, 70). Hematopoietic stem cell (HSC) transplantation can be curative, but the majority of patients do not have a suitable donor (80). Advanced gene editing technologies also offer the possibility of a cure (16, 34), but the likelihood that these strategies can be mobilized to treat the large numbers of patients residing in developing countries is remote...
August 1, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/30066633/netcontrol4biomed-a-pipeline-for-biomedical-data-acquisition-and-analysis-of-network-controllability
#15
Krishna Kanhaiya, Vladimir Rogojin, Keivan Kazemi, Eugen Czeizler, Ion Petre
BACKGROUND: Network controllability focuses on discovering combinations of external interventions that can drive a biological system to a desired configuration. In practice, this approach translates into finding a combined multi-drug therapy in order to induce a desired response from a cell; this can lead to developments of novel therapeutic approaches for systemic diseases like cancer. RESULT: We develop a novel bioinformatics data analysis pipeline called NetControl4BioMed based on the concept of target structural control of linear networks...
July 9, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/30064950/defining-minimum-necessary-anticoagulation-related-communication-at-discharge-consensus-of-the-care-transitions-task-force-of-the-new-york-state-anticoagulation-coalition
#16
Darren Triller, Anne Myrka, John Gassler, Kelly Rudd, Patrick Meek, Peter Kouides, Allison E Burnett, Alex C Spyropoulos, Jack Ansell
BACKGROUND: Anticoagulated patients are particularly vulnerable to ADEs when they experience changes in medical acuity, pharmacotherapy, or care setting, and resources guiding care transitions are lacking. The New York State Anticoagulation Coalition convened a task force to develop a consensus list of requisite data elements (RDEs) that should accompany all anticoagulated patients undergoing care transitions. METHODS: A multidisciplinary panel of 15 anticoagulation experts voluntarily completed an iterative Delphi process...
July 24, 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/30064310/endovascular-delivery-of-leads-and-stentrodes-and-their-applications-to-deep-brain-stimulation-and-neuromodulation-a-review
#17
Gary Rajah, Hamidreza Saber, Rasanjeet Singh, Leonardo Rangel-Castilla
Neuromodulation and deep brain stimulation (DBS) have been increasingly used in many neurological ailments, including essential tremor, Parkinson's disease, epilepsy, and more. Yet for many patients and practitioners the desire to utilize these therapies is met with caution, given the need for craniotomy, lead insertion through brain parenchyma, and, at many times, bilateral invasive procedures. Currently endovascular therapy is a standard of care for emergency thrombectomy, aneurysm treatment, and other vascular malformation/occlusive disease of the cerebrum...
August 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/30064269/indications-for-and-outcome-in-patients-with-the-wearable-cardioverter-defibrillator-in-a-nurse-based-training-programme-results-of-the-austrian-wcd-registry
#18
Tanja Odeneg, Christian Ebner, Deddo Mörtl, Hans Keller, Alfred Dirninger, Günter Stix, Bernhard Föger, Georg Grimm, Clemens Steinwender, Franz Gebetsberger, Markus Stühlinger, Bernadette Mastnak, Christian Haider, Martin Manninger, Daniel Scherr
BACKGROUND: The wearable cardioverter-defibrillator is a treatment option for patients at temporarily high risk of sudden cardiac death or in whom implantation of a cardioverter-defibrillator is temporarily not possible. OBJECTIVES: The aim of this study was to provide real-world data on patients receiving this therapy in a nurse-based wearable cardioverter-defibrillator training programme. METHODS: A registry including all patients prescribed with a wearable cardioverter-defibrillator in Austria between 2010 and 2016...
August 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/30063990/predicted-longevity-of-contemporary-cardiac-implantable-electronic-devices-a-call-for-industry-wide-standardized-reporting
#19
Dian A Munawar, Rajiv Mahajan, Dominik Linz, Geoffrey R Wong, Kashif B Khokhar, Anand Thiyagarajah, Kadhim Kadhim, Mehrdad Emami, Ricardo Mishima, Adrian D Elliott, Melissa E Middeldorp, Kurt C Roberts-Thompson, Glenn D Young, Prashanthan Sanders, Dennis H Lau
BACKGROUND: Battery longevity is an important factor that may influence the selection of cardiac implantable electronic devices (CIEDs). Unfortunately, there remains a lack of industry-wide standardized reporting of predicted CIEDs longevity to facilitate informed decision making for implanting physicians and payers. OBJECTIVE: To compare the predicted longevity of current generation CIEDs using best-matched CIEDs settings to assess differences between brands and models...
July 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30050718/an-atypical-presentation-of-pediatric-acute-neuropsychiatric-syndrome-responding-to-plasmapheresis-treatment
#20
Drew H Barzman, Hannah Jackson, Umesh Singh, Marcus Griffey, Michael Sorter, Jonathan A Bernstein
Here we report a case of a 15-year-old female who had originally been diagnosed and treated unsuccessfully for schizophrenia, psychosis, severe anxiety, and depression. More in-depth history revealed an abrupt onset of her symptoms with remote acute infections and many exhibited characteristics of obsessive compulsive disorder with rituals. Work-up for underlying infectious, immunodeficiency, and autoimmune causes was unrevealing except for very high levels of anti-neuronal antibodies which have been linked to Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)...
2018: Case Reports in Psychiatry
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