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adherence treatment schizophrenia

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https://www.readbyqxmd.com/read/29766576/predictive-factors-of-overall-functioning-improvement-in-patients-with-chronic-schizophrenia-and-schizoaffective-disorder-treated-with-paliperidone-palmitate-and-aripiprazole-monohydrate
#1
Paolo Girardi, Antonio Del Casale, Chiara Rapinesi, Georgios D Kotzalidis, Francesca Splendori, Claudio Verzura, Giada Trovini, Serena Sorice, Dario Carrus, Iginia Mancinelli, Anna Comparelli, Sergio De Filippis, Antonio Francomano, Andrea Ballerini, Andrea Marcellusi, Francesco S Mennini, Giuseppe Ducci, Gabriele Sani, Maurizio Pompili, Roberto Brugnoli
BACKGROUND: Long-acting injectable (LAI) antipsychotics can improve medication adherence and reduce hospitalisation rates compared with oral treatments. Paliperidone palmitate (PAL) and aripiprazole monohydrate (ARI) LAI treatments were associated with improvements in global functioning in patients with schizophrenia. OBJECTIVE: The objective of this study was to assess the predictive factors of better overall functioning in patients with chronic schizophrenia and schizoaffective disorder treated with PAL and ARI...
May 15, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29764266/impact-of-paliperidone-palmitate-one-month-formulation-on-relapse-prevention-in-patients-with-schizophrenia-a-post-hoc-analysis-of-a-one-year-open-label-study-stratified-by-medication-adherence
#2
Tianmei Si, Nan Li, Huafei Lu, Shangli Cai, Jianmin Zhuo, Christoph U Correll, Lili Zhang, Yu Feng
BACKGROUND: Limited data are available to help identify patients with schizophrenia who are most likely to benefit from long-acting injectable antipsychotics. AIM: The purpose of this study was to investigate the efficacy of long-acting injectable antipsychotic paliperidone palmitate one-month formulation for preventing relapses, factors influencing time to first relapse, and the effect of different antipsychotic adherence levels on time to first relapse in Chinese patients with schizophrenia...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29735155/abnormal-trajectory-of-intracortical-myelination-in-schizophrenia-implicates-white-matter-in-disease-pathophysiology-and-the-therapeutic-mechanism-of-action-of-antipsychotics
#3
Todd A Tishler, George Bartzokis, Po H Lu, Erika P Raven, Mher Khanoyan, Chandra J Kirkpatrick, Meghan H Pyle, J Pablo Villablanca, Lori L Altshuler, Jim Mintz, Joseph Ventura, Laurie R Casaus, Kenneth L Subotnik, Keith H Nuechterlein, Benjamin M Ellingson
BACKGROUND: Postmortem and imaging studies provide converging evidence that the frontal lobe myelination trajectory is dysregulated in schizophrenia (SZ) and suggest that early in treatment, antipsychotic medications increase intracortical myelin (ICM). We used magnetic resonance imaging to examine whether the ICM trajectory in SZ is dysregulated and altered by antipsychotic treatment. METHODS: We examined 93 subjects with SZ (64 men and 29 women) taking second-generation oral antipsychotics with medication exposures of 0-333 months in conjunction with 80 healthy control subjects (52 men and 28 women)...
May 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29730045/improving-cognitive-training-for-schizophrenia-using-neuroplasticity-enhancers-lessons-from-decades-of-basic-and-clinical-research
#4
G D Guercio, M E Thomas, J M Cisneros-Franco, P Voss, R Panizzutti, E de Villers-Sidani
Mounting evidence indicates that schizophrenia is a disorder that stems from maladaptive plasticity within neural circuits and produces broad cognitive deficits leading to loss of autonomy. A large number of studies have identified abnormalities spanning many neurotransmitter systems in schizophrenia, and as a result, a variety of drugs have been developed to attempt to treat these abnormalities and enhance cognition. Unfortunately, positive results have been limited so far. This may be in part because the scope of abnormalities in the schizophrenic brain requires a treatment capable of engaging many different neurotransmitter systems...
May 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29726625/sharing-information-about-diagnosis-and-outcome-of-first-episode-psychosis-in-patients-presenting-to-early-intervention-services
#5
Saeed Farooq, Debra J Green, Swaran P Singh
AIM: First-episode psychosis (FEP) can be a serious and debilitating disease, but there is limited literature on how to inform patients and carers about its diagnosis and outcome. We aimed to examine the attitudes, practices and views of clinicians working in Early Intervention Service about sharing information on diagnosis and outcome of FEP. METHODS: A 26-item questionnaire was sent electronically to clinical staff who have been involved in the discussion of FEP diagnosis in Early Intervention Services in the West Midlands, UK...
May 4, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29722547/adherence-and-economic-impact-of-paliperidone-palmitate-versus-oral-atypical-antipsychotics-in-a-medicare-population
#6
Kruti Joshi, Erik Muser, Yihua Xu, Phil Schwab, Manasi Datar, Brandon Suehs
AIM: To compare adherence, healthcare utilization and costs among real world, Medicare-eligible patients with schizophrenia using long-acting injectable paliperidone palmitate (PP) versus oral atypical antipsychotics. Patients & methods: Historical cohort study used Medicare Advantage claims data. Inverse probability of treatment weighting was applied to adjust for baseline differences. 12-month adherence, healthcare utilization and costs were compared. RESULTS: Patients using PP were more adherent (proportion of days covered ≥0...
May 3, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29702756/antipsychotic-free-status-in-community-dwelling-patients-with-schizophrenia-in-china-comparisons-within-and-between-rural-and-urban-areas
#7
Cai-Lan Hou, Miao-Yang Chen, Mei-Ying Cai, Zi-Lang Chen, Shou-Bin Cai, Yao-Nan Xiao, Fu-Jun Jia
OBJECTIVE: To date, no study has specifically compared antipsychotic-free patients with schizophrenia living in the community between rural and urban areas. This study examined the rural-urban differences among antipsychotic-free community-dwelling individuals with schizophrenia in China. METHODS: Data on 1,365 community-dwelling patients with schizophrenia (n = 742 in a rural area and n = 623 in an urban area) with diagnoses according to DSM-IV or ICD-10 were collected by interviews during 2013-2014 and 2015-2016...
April 10, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29700755/does-non-adherence-increase-treatment-costs-in-schizophrenia
#8
REVIEW
Mark Pennington, Paul McCrone
INTRODUCTION: Medication non-adherence is a serious barrier to treatment of schizophrenia. Understanding the impact of non-adherence on costs is essential to the assessment of the cost effectiveness of interventions in which adherence to treatment is a concern. OBJECTIVES: We undertook a comprehensive review of the available literature on the impact on costs of non-adherence to antipsychotics in the treatment of schizophrenia. METHODS: We performed a search on multiple databases (MEDLINE, Embase, PsycINFO and Health Management Information Consortium) for any study reporting the impact of adherence to antipsychotics on costs in patients with schizophrenia up to February 2018...
April 26, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29621261/a-multicenter-randomized-controlled-trial-of-individualized-occupational-therapy-for-patients-with-schizophrenia-in-japan
#9
Takeshi Shimada, Manami Ohori, Yusuke Inagaki, Yuko Shimooka, Naoya Sugimura, Ikuyo Ishihara, Tomotaka Yoshida, Masayoshi Kobayashi
The individualized occupational therapy (IOT) program is a psychosocial program that we developed to facilitate proactive participation in treatment and improve cognitive functioning and other outcomes for inpatients with acute schizophrenia. The program consists of motivational interviewing, self-monitoring, individualized visits, handicraft activities, individualized psychoeducation, and discharge planning. This multicenter, open-labeled, blinded-endpoint, randomized controlled trial evaluated the impact of adding IOT to a group OT (GOT) program as usual for outcomes in recently hospitalized patients with schizophrenia in Japanese psychiatric hospitals setting compared with GOT alone...
2018: PloS One
https://www.readbyqxmd.com/read/29569082/long-acting-injectable-second-generation-antipsychotics-an-update-and-comparison-between-agents
#10
REVIEW
Michael W Jann, Scott R Penzak
Schizophrenia is a chronic medical condition with periods of remission and relapses over a patient's lifetime. Antipsychotic medications represent the mainstay of treatment for this disease. Long-acting injectable (LAI) formulations of antipsychotics are an attractive alternative to their oral counterparts, as they enhance patient adherence. A number of second-generation antipsychotics (SGAs) are available in LAI formulations. These include paliperidone, aripiprazole, olanzapine, and risperidone. This article reviews the most recently developed and approved of these formulations-aripiprazole monohydrate, aripiprazole lauroxil, and paliperidone palmitate...
March 22, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29563800/efficacy-tolerability-and-safety-of-oral-paliperidone-extended-release-in-the-treatment-of-schizophrenia-a-24-week-open-label-prospective-switch-study-in-different-settings-in-taiwan
#11
Ching-Yen Chen, Tze-Chun Tang, Tzu-Ting Chen, Ya Mei Bai, Huei-Huang Tsai, Hou-Liang Chen, Chun-Jen Huang, Chih-Ken Chen, Chun-Chih Chen, Mei-Chun Hsiao, Chia-Yih Liu, Hong-Shiow Yeh, Nan-Ying Chiu, Cheng-Chen Hsiao, Cheng-Sheng Chen, Tung-Ping Su
Purpose: Paliperidone extended release (ER) is an oral psychotropic treatment formulated to release paliperidone at a controlled, gradually ascending rate. We evaluated the efficacy and safety of switching to paliperidone ER in Taiwanese patients with schizophrenia who were unresponsive or intolerant to previous antipsychotic therapy. Patients and methods: This was a 24-week, open-label, single-arm, multicenter, Phase IV trial. Based on consulting psychiatrists' judgment, patients were deemed eligible for the switch to paliperidone ER; the switch was achieved by cross-tapering, using a recommended starting dose of 6 mg...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29540411/psychological-interventions-for-positive-symptoms-in-schizophrenia-protocol-for-a-network-meta-analysis-of-randomised-controlled-trials
#12
Irene Bighelli, Georgia Salanti, Cornelia Reitmeir, Sofia Wallis, Corrado Barbui, Toshi A Furukawa, Stefan Leucht
INTRODUCTION: There is rising awareness that we need multidisciplinary approaches integrating psychological treatments for schizophrenia, but a comprehensive evidence based on their relative efficacy is lacking. We will conduct a network meta-analysis (NMA), integrating direct and indirect comparisons from randomised controlled trials (RCTs) to rank psychological treatments for schizophrenia according to their efficacy, acceptability and tolerability. METHODS AND ANALYSIS: We will include all RCTs comparing a psychological treatment aimed at positive symptoms of schizophrenia with another psychological intervention or with a no treatment condition (waiting-list and treatment as usual)...
March 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29536020/patterns-of-prescription-of-psychotropic-medications-and-their-adherence-among-patients-with-schizophrenia-in-two-psychiatric-hospitals-in-accra-ghana-a-cross-sectional-survey
#13
Sharon Ashong, Irene A Kretchy, Barima Afrane, Ama de-Graft Aikins
Background: Patients with schizophrenia are managed with antipsychotics and other psychotropic medications. Objectives: This study aimed to assess the commonly prescribed psychotropic medications for patients with schizophrenia, explore the types of therapeutic monitoring that were performed, and find out whether the side effects experienced by the patients played any role in their adherence behaviour. Methods: This hospital-based cross-sectional study enrolled 259 patients with schizophrenia from Accra Psychiatric Hospital and Pantang Psychiatric Hospital...
2018: Psychiatry Journal
https://www.readbyqxmd.com/read/29528032/can-a-digital-medicine-system-improve-adherence-to-antipsychotic-treatment
#14
D Papola, C Gastaldon, G Ostuzzi
A substantial proportion of people with mental health conditions do not adhere to prescribed pharmacological treatments. Poor adherence is probably one of the most critical elements contributing to relapse in people with schizophrenia and other severe mental disorders. In order to tackle this global issue, in November 2017 the Food and Drug Administration approved a tablet formulation of the atypical antipsychotic aripiprazole embedded with a novel digital adherence-assessment device. In this commentary, we critically appraised the potential beneficial and harmful consequences of this new digital formulation of aripiprazole, and we highlighted expected implications for clinical practice...
June 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29521010/medication-adherence-in-first-episode-psychosis-patients-in-singapore
#15
Chunzhen Tan, Edimansyah Abdin, Wilfred Liang, Lye Yin Poon, Ngar Yee Poon, Swapna Verma
AIM: Early intervention programmes for first episode psychosis (FEP) aim to reduce the duration of untreated psychosis (DUP) and improve functional outcomes. The sustained maintenance of improved outcomes depends largely on patients' adherence to prescribed treatment. This paper examines the prevalence of non-adherence in a cohort of patients with FEP and the sociodemographic and clinical factors associated with non-adherent behaviour. METHODS: The sample included consecutive patients accepted from 2007 to 2012 into the Early Psychosis Intervention Programme (EPIP) in Singapore...
March 9, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29516094/association-of-schizophrenia-with-the-risk-of-breast-cancer-incidence-a-meta-analysis
#16
Chuanjun Zhuo, Patrick Todd Triplett
Importance: Patients with schizophrenia are considered to have many risk factors for the development of cancer. However, the incidence of breast cancer in women with schizophrenia compared with the general population remains uncertain. Objective: To perform an updated meta-analysis to evaluate the association between schizophrenia and the risk of breast cancer. Data Sources: A systematic search of the PubMed and EMBASE databases was conducted using the search terms schizophrenia, schizophrenic, psychosis, combined with breast and cancer, tumor, neoplasm, or carcinoma...
April 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29507604/analysis-of-the-health-insurance-review-and-assessment-service-data-from-2011-to-2015
#17
Sang-Uk Lee, Minah Soh, Vin Ryu, Chul-Eung Kim, Subin Park, Sungwon Roh, In-Hwan Oh, Hye-Young Lee, SungKu Choi
Background: Schizophrenia is a recurrent, debilitating disease that is rarely curable. Rapid intervention after the first episode of schizophrenia has been shown to positively affect the prognosis. Unfortunately, basic data is scarce on first-episode schizophrenia in Korean patients making it difficult to create a comprehensive list of risk factors for relapse. This study aims to investigate the demographic characteristics and institutional factors of patients with first-episode schizophrenia in order to identify risk factors for relapse...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29505193/long-acting-injectable-antipsychotics-where-do-they-fit-in-the-treatment-plan
#18
Christoph U Correll, John Lauriello
Long-acting injectable (LAI) antipsychotics have the potential to improve adherence and outcomes for patients with serious mental illness but are underused. Watch this Webcast to learn how to identify patients who may benefit from using LAIs, monitor treatment adherence, and use LAIs safely and effectively in patients with schizophrenia and related disorders.
January 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29498481/predictors-of-remission-during-acute-treatment-of-first-episode-schizophrenia-patients-involuntarily-hospitalized-and-treated-with-algorithm-based-pharmacotherapy-secondary-analysis-of-an-observational-study
#19
Bunta Yoshimura, Shinji Sakamoto, Kojiro Sato, Manabu Takaki, Norihito Yamada
AIM: Early clinical response predicts symptomatic remission and recovery in the maintenance treatment phase of first-episode schizophrenia (FES). However, little is known about predictors of symptomatic remission during acute treatment of severely ill patients with FES. Here, we conducted a secondary analysis of our retrospective observational study, which examined response, remission and treatment-resistance rates in seriously ill patients with FES spectrum disorders involuntarily hospitalized and treated with algorithm-based pharmacotherapy...
December 12, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29472872/pharmacoresistant-severe-mental-health-disorders-in-children-and-adolescents-functional-abnormalities-of-cytochrome-p450-2d6
#20
Susanne Thümmler, Emmanuelle Dor, Renaud David, Graziella Leali, Michele Battista, Alexia David, Florence Askenazy, Céline Verstuyft
Background: Severe mental health disorders in children and adolescents represent a major public health problem. Despite adequate drug treatment, some patients develop pharmacoresistant disease. As a consequence, physicians are confronted with prescribing challenges, prolonged hospitalization and increased risk of adverse events, thus aggravating short-, medium-, and long-term prognosis. The majority of psychotropic treatments, particularly antipsychotics and antidepressants, are metabolized at hepatic level by cytochrome P450 (CYP), particularly by CYP3A4 and CYP2D6...
2018: Frontiers in Psychiatry
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