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treatment of threatened abortion

Eun-Yeong Kim, Hee-Jung Choi, Tae-Wook Chung, Jun-Yong Choi, Hyung Sik Kim, Yeon-Seop Jung, Syng-Ook Lee, Ki-Tae Ha
The leaves and stems of Perilla frutescens var. acuta Kudo (PF) have been used to prevent threatened abortion in traditional medicine in the East Asian countries. Because reduced receptivity of endometrium is a cause of abortion, we analyzed the action of PF on the endometrial receptivity. PF increased the level of leukemia inhibitory factor (LIF), a major cytokine regulating endometrial receptivity, and LIF receptor in human endometrial Ishikawa cells. The PF-induced LIF expression was mediated by c-jun N-terminal kinase (JNK) and p38 pathways...
August 2016: Journal of Pharmacological Sciences
F B Sako, F A Traoré, M K Camara, M Sylla, E F Bangoura, O Baldé
Cholera is an epidemic diarrheal disease transmitted through the digestive tract; it can cause obstetric complications in pregnant women. The objective of this study was to describe the epidemiological, clinical, and therapeutic aspects of cholera in pregnant women, as well as its course, during the 2012 epidemic in Conakry. This retrospective, descriptive studied examined the records of this epidemic over a 7-month period (from May 15 to December 15, 2012). Of 2,808 cholera patients at our hospital, 80 were pregnant, that is, 2...
May 1, 2016: Médecine et Santé Tropicales
Yi Zhang, Wei Yan, Pu-Feng Ge, Yan Li, Qian Ye
OBJECTIVE: To observe preventive and therapeutic effects and the mechanism of actions on Zishen Yutai pill combined with progesterone on threatened abortion in rats. METHODS: After pregnancy, 50 SPF female SD rats were selected and divided into control group, model group, progesterone group, Zishen Yutai pill group, and progesterone plus Zishen Yutai pill group (combination group), with 10 rats in each group. The rats of control group and abortion model group were lavaged with 2 mL/kg normal saline on pregnancy day 1 for continuous 10 days...
June 2016: Asian Pacific Journal of Tropical Medicine
L Granata, H Niebergall, R Langner, R Agosti, L Sakellaris
Cluster headaches have an incidence of 1-3 per 10,000 with a 2.5:1 male-to-female gender ratio. Although not life threatening, the impact of the attacks on the individual patient can result in tremendous pain and disability. The pathophysiology of the disease is unclear, but it is known that the hypothalamus, the brainstem, and genetic factors, such as the G1246A polymorphism, play a role. A distinction is made between episodic and chronic cluster headaches. In a controlled setting, we treated 29 patients with cluster headaches (13 with chronic cluster and 16 with the episodic form), who had been refractory to conventional treatments, with a low dose of ketamine (an NMDA receptor antagonist) i...
June 2016: Der Schmerz
N Nguyen Duc, D Drmlová, Š Urbánek
OBJECTIVE: To present a case of intracranial haemorrhage due to decompensated hypertension in case of severe preeclampsia which resulted in acute caesarean section followed by hysterectomy. DESIGN: Case report. SETTING: Department of Obstetrics and Gynaecology, Hospital Kladno. CASE REPORT: We report the case of a 36-year old multiparous woman in the 35th week of pregnancy with no prenatal care. According to her medical history, she had a caesarean section three years earlier and six previous spontaneous deliveries without complications (including spontaneously delivered twins)...
January 2016: Ceská Gynekologie
Andrea Mazzanti, Riccardo Maragna, Alessandro Faragli, Nicola Monteforte, Raffaella Bloise, Mirella Memmi, Valeria Novelli, Paola Baiardi, Vincenzo Bagnardi, Susan P Etheridge, Carlo Napolitano, Silvia G Priori
BACKGROUND: Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for the alpha-subunit of the sodium channel NaV1.5. Mexiletine is used to block late sodium current and to shorten QT interval in LQT3 patients. OBJECTIVES: The aim of this study was to determine whether mexiletine prevents arrhythmic events (arrhythmic syncope, aborted cardiac arrest, or sudden cardiac death) in LQT3 patients. METHODS: The endpoint of this retrospective cohort study, which studied consecutive LQT3 patients who were referred to our center and treated with mexiletine, was to evaluate the antiarrhythmic efficacy of mexiletine by comparing the number of arrhythmic events per patient and the annual rate of arrhythmic events during observation periods of equal duration before and after the beginning of therapy with mexiletine...
March 8, 2016: Journal of the American College of Cardiology
Qi-Bin Lu, Shu Zhu
OBJECTIVE: To evaluate Chinese medicine prescription, Anzi Heji (, AZHJ), on immune regulation of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) in anticardiolipin antibody (ACA)-positive patients with threatened abortion. METHODS: Twenty-seven ACA-positive female patients with threatened abortion in the study group were treated with an aqueous extract of AZHJ 125 mL, twice daily for 4 consecutive weeks. The results were compared with control group composed by 15 healthy pregnant women...
February 26, 2016: Chinese Journal of Integrative Medicine
Ravleen Kaur Bakshi, Debabrata Roy, Pradeep Aggarwal, Ruchira Nautiyal, Jaya Chaturvedi, Rakesh Kakkar
INTRODUCTION: Women who experienced and survived a severe health condition during pregnancy, childbirth or postpartum are considered as 'near-miss' or severe acute maternal morbidity (SAMM) cases. Women who survive life-threatening conditions arising from complications related to pregnancy and childbirth have many common aspects with those who die of such complications. AIM: To evaluate health-care facility preparedness and perfor-mance in reducing severe maternal out comes at all levels of health care...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Ajay Gupta
PURPOSE OF REVIEW: This article provides an update on the current understanding and management of febrile seizures. Febrile seizures are one of the most common age-related epileptic convulsions that lead to outpatient consultations, emergency department visits, and hospital or intensive care admissions. RECENT FINDINGS: The Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study, an ongoing multicenter prospective longitudinal study, is providing valuable insights into the subset of patients who develop febrile status epilepticus, the most life-threatening type of febrile seizures with potential long-term consequences...
February 2016: Continuum: Lifelong Learning in Neurology
Shilin Zhang, Guoqing Liu, Yongfu Duo, Jianfeng Wang, Jierong Li, Chunjing Li
BACKGROUND: Although the application of ureteroscopy in the treatment of ureteral calculi during pregnancy has been on the rise, for persistent renal colic patients without ultrasound-detected ureteral calculi, it may represent a clinical dilemma due to the potential risks for both mother and fetus. OBJECTIVE: The aim of the present study is to present our experience with the application of the ureteroscope in the emergency treatment of persistent renal colic patients during pregnancy...
2016: PloS One
Sarah Hudak, Martin Kächele, Melanie Henes, Ralf Rothmund, Kilian Rittig, Bernd Balletshofer, Elko Randrianarisoa
HISTORY AND ADMISSION FINDINGS: We report on two pregnant women with dyspnoe and thoracic pain in the context of an ovarian hyperstimulation syndrome. INVESTIGATIONS: Both patients had pleural effusions. The first patient was diagnosed with pulmonary embolism via computer tomography. In the second patient, thrombosis of the upper part of the body including intracranial thrombosis was revealed via magnetic resonance and ultrasound imaging. In both cases, thrombosis was caused by ovarian hyperstimulation...
January 2016: Deutsche Medizinische Wochenschrift
Barry J Maron, Ethan J Rowin, Susan A Casey, John R Lesser, Ross F Garberich, Deepa M McGriff, Martin S Maron
BACKGROUND: Youthful age has been considered the time of greatest risk for patients with hypertrophic cardiomyopathy (HCM), largely because of the possibility of sudden death. The last 2 decades have witnessed more reliable identification of at-risk patients and utilization of implantable cardioverter-defibrillators for prevention of sudden death, and other contemporary treatment options. Whether such management advances have significantly altered the considerable mortality rate for young HCM patients remains unresolved...
January 5, 2016: Circulation
Kriangsak Khamim, Boonluck Khamim, Krisana Pengsaa
While dengue infection is still on the increase in adults in Thailand, it also affects pregnant women, especially pregnant teenagers. This study was designed to investigate dengue infection during pregnancy. Seven cases of dengue infection in pregnant women were admitted to Ban Pong Hospital, Ratchaburi, Thailand, between 2008 and 2012. Dengue infection presented in all pregnancy trimesters. There were two severe cases: one was dengue hemorrhagic fever in the first trimester, and the second was at a critical stage of the infection during labor...
2015: Southeast Asian Journal of Tropical Medicine and Public Health
José Luis Martínez-Ordaz, Magdely Yazmin Morales-Camacho, Sócrates Centellas-Hinojosa, Eduardo Román-Ramírez, Teodoro Romero-Hernández, Mauricio de la Fuente-Lira
BACKGROUND: Choledochal cysts are rare. They usually present during childhood in women, but it can also be seen during pregnancy. Clinical signs and symptoms are obscured during this time, thus it can complicate the diagnosis and represent a life threatening complication for both the mother and the child. OBJECTIVE: To communicate the case of 3 pregnant patients with choledochal cyst. CLINICAL CASES: Three pregnant women in which choledochal cyst were diagnosed...
March 2016: Cirugia y Cirujanos
Deborah S Raithel, Kirsten H Ohler, Isabel Porto, Alma R Bicknese, Donna M Kraus
Paroxysmal sympathetic hyperactivity (PSH) is a life-threatening condition characterized by hyperadrenergic activity and autonomic dysfunction. Also termed autonomic storms, PSH can occur after a variety of cerebral insults, most commonly traumatic brain injury. Limited pediatric literature is available, especially in patients with brain injury from hypoxia. No consensus exists for the terminology, diagnostic criteria, or treatment algorithm for PSH. Thus, the optimal management, including medication selection and dosing, remains unclear...
July 2015: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Yonca Özkan Arat, Anıl Arat, Kubilay Aydın
BACKGROUND: Cerebrovascular trauma secondary to transorbital intracranial penetrating injury (TIPVI) is rare. Relatively benign initial presentation may mask the underlying life-threatening vascular injury in transorbital intracranial penetrations. The aim of this study was to evaluate clinical features and endovascular treatment of TIPVI. METHODS: Six patients with angiographic documentation of TIPVI in subacute/chronic phase were reviewed retrospectively. Five were treated endovascularly; however endovascular treatment was aborted in one and conservative management was pursued...
July 2015: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Gustavo Vilchez, Miguel Espinoza, Guery D'Onadio, Pedro Saona, Eduardo Gotuzzo
OBJECTIVE: Brucellosis is a zoonosis with high morbidity in humans. This disease has gained interest recently due to its re-emergence and potential for weaponization. Pregnant women with this disease can develop severe complications. Its association with adverse obstetric outcomes is not clearly understood. The objective of this study was to describe the obstetric outcomes of brucellosis in pregnancy. METHODS: Cases of pregnant women with active brucellosis seen at the Hospital Nacional Cayetano Heredia from 1970 to 2012 were reviewed...
September 2015: International Journal of Infectious Diseases: IJID
D Schlembach, K I Mayer-Pickel, M Cervar-Zivkovic, M G Moertl, U Lang, E Schleussner
INTRODUCTION: Antiphospholipid syndrome (APS), is an autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids provoking arterial and venous thromboses as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, or severe preeclampsia. The syndrome occurs due to the autoimmune production of antibodies against phospholipid (aPL), a cell membrane substance. In particular, the disease is characterised by antibodies against cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I...
July 2012: Pregnancy Hypertension
Gaetano M De Ferrari, Veronica Dusi, Carla Spazzolini, J Martijn Bos, Dominic J Abrams, Charles I Berul, Lia Crotti, Andrew M Davis, Michael Eldar, Maria Kharlap, Asaad Khoury, Andrew D Krahn, Antoine Leenhardt, Christopher R Moir, Attilio Odero, Louise Olde Nordkamp, Thomas Paul, Ferran Rosés I Noguer, Maria Shkolnikova, Jan Till, Arthur A M Wilde, Michael J Ackerman, Peter J Schwartz
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β-Βlockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) are used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evidence remains anecdotal...
June 23, 2015: Circulation
Adolf E Schindler, Howard Carp, René Druckmann, Andrea R Genazzani, Johannes Huber, Jorge Pasqualini, Karl W Schweppe, Julia Szekeres-Bartho
This guideline has been developed based on studied and clinical investigations. Therefore, it appears to be appropriate to use all the available evidence, which are very encouraging, in a summarized form to propose guidelines by a group of European experts in order to give the gynecologists, obstetricians and reproductive medicine specialists have direction with regard to the prevention or treatment of miscarriage for the benefit of the endangered pregnancies. There are a number of statements, opinions and guidelines already published for this topic, which are not entirely in agreement...
June 2015: Gynecological Endocrinology
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