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https://www.readbyqxmd.com/read/28110366/atomoxetine-treatment-for-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-adhd-a-comprehensive-meta-analysis-of-outcomes-on-parent-rated-core-symptomatology
#1
REVIEW
Jessica L Gayleard, Matthew P Mychailyszyn
Attention-Deficit/Hyperactivity Disorder (ADHD) impacts a significant number of children and adolescents and often leads to deleterious functional impairment. Psychostimulant medication has historically been the first line of pharmacological intervention, though recent years have seen greater attention paid to non-stimulant alternatives. The objective of the present study was to conduct the most comprehensive meta-analysis to date evaluating the efficacy of atomoxetine in reducing core symptomatology of ADHD according to parent report...
January 21, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28109652/epilepsy-in-patients-with-grin2a-alterations-genetics-neurodevelopment-epileptic-phenotype-and-response-to-anticonvulsive-drugs
#2
C von Stülpnagel, M Ensslen, R S Møller, D K Pal, S Masnada, P Veggiotti, E Piazza, M Dreesmann, T Hartlieb, T Herberhold, E Hughes, M Koch, C Kutzer, K Hoertnagel, J Nitanda, M Pohl, K Rostásy, T B Haack, K Stöhr, G Kluger, I Borggraefe
OBJECTIVE: To delineate the genetic, neurodevelopmental and epileptic spectrum associated with GRIN2A alterations with emphasis on epilepsy treatment. METHODS: Retrospective study of 19 patients (7 females; age: 1-38 years; mean 10.1 years) with epilepsy and GRIN2A alteration. Genetic variants were classified according to the guidelines and recommendations of the American College of Medical Genetics (ACMG). Clinical findings including epilepsy classification, treatment, EEG findings, early childhood development and neurodevelopmental outcome were collected with an electronic questionnaire...
January 14, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28109480/validation-of-the-littlears-auditory-questionnaire-in-cochlear-implanted-infants-and-toddlers
#3
Anita Obrycka, Artur Lorens, José-Luis Padilla García, Anna Piotrowska, Henryk Skarzynski
OBJECTIVES: The LittlEARS Auditory Questionnaire (LEAQ) has so far been validated to assess auditory development in groups of normal-hearing children in over 20 different languages. Considering the huge variability in auditory development of CI children, especially since candidacy criteria have been relaxed, additional evidence to validate the use of LEAQ scores in this particular population is needed. The aim of this study is to provide evidence for the reliability and validity of LEAQ scores for assessing the auditory development of CI infants and toddlers based on an evaluation of LEAQ's internal structure and its relation to other variables...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109477/clinical-outcomes-following-cochlear-implantation-in-children-with-inner-ear-anomalies
#4
Amal Isaiah, Daniel Lee, Felicity Lenes-Voit, Melissa Sweeney, Walter Kutz, Brandon Isaacson, Peter Roland, Kenneth H Lee
OBJECTIVE: A significant proportion of children with congenital hearing loss who are candidates for cochlear implants (CIs) may have inner ear malformations (IEMs). Surgical and speech outcomes following CI in these children have not been widely reported. METHODS: The charts of children who were evaluated for a CI between 1/1/1986 and 12/31/2014 at a university-based tertiary level pediatric cochlear implant center were reviewed. Principal inclusion criteria included (i) age 1-18 years, (ii) history of bilateral severe to profound sensorineural hearing loss, and (iii) limited benefit from binaural amplification...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109313/can-an-educational-podcast-improve-the-ability-of-parents-of-primary-school-children-to-assess-the-reliability-of-claims-made-about-the-benefits-and-harms-of-treatments-study-protocol-for-a-randomised-controlled-trial
#5
Daniel Semakula, Allen Nsangi, Matt Oxman, Astrid Austvoll-Dahlgren, Sarah Rosenbaum, Margaret Kaseje, Laetitia Nyirazinyoye, Atle Fretheim, Iain Chalmers, Andrew D Oxman, Nelson K Sewankambo
BACKGROUND: Claims made about the effects of treatments are very common in the media and in the population more generally. The ability of individuals to understand and assess such claims can affect their decisions and health outcomes. Many people in both low- and high-income countries have inadequate aptitude to assess information about the effects of treatments. As part of the Informed Healthcare Choices project, we have prepared a series of podcast episodes to help improve people's ability to assess claims made about treatment effects...
January 21, 2017: Trials
https://www.readbyqxmd.com/read/28109250/diagnosis-of-celiac-disease-and-applicability-of-espghan-guidelines-in-mediterranean-countries-a-real-life-prospective-study
#6
Andrea Smarrazzo, Zrinjka Misak, Stefano Costa, Dušanka Mičetić-Turk, Mona Abu-Zekry, Aydan Kansu, Abdelhak Abkari, Karim Bouziane-Nedjadi, Mongi Ben Hariz, Eleftheria Roma, Virtut Velmishi, Maria Legarda Tamara, Thomas Attard, Veselinka Djurisic, Luigi Greco, Giuseppe Magazzù
BACKGROUND: We assessed how the diagnosis of Celiac Disease (CD) is made and how the new ESPGHAN guidelines can be applied in children from countries with different resources. METHODS: A real life prospective study was performed in 14 centres of 13 different Mediterranean countries. Participants were asked to apply the usual diagnostic work-up for CD according to their diagnostic facilities. RESULTS: There were 1974 patients enrolled in the study, mean age 4 years, 10 months; 865 male, 1109 female...
January 21, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28109052/the-use-of-methadone-to-facilitate-opioid-weaning-in-pediatric-critical-care-patients-a-systematic-review-of-the-literature-and-meta-analysis
#7
REVIEW
Leslie A Dervan, Beryl Yaghmai, Robert Scott Watson, Fredric M Wolf
BACKGROUND: Continuous opioid infusion therapy is commonly utilized in the pediatric intensive care setting to treat pain and facilitate tolerance of invasive therapies. Transitioning to methadone is one common strategy for weaning from continuous opioid infusions, but in practice this transition can be challenging, and many children still experience iatrogenic withdrawal. AIM: We reviewed the literature to evaluate the best available evidence to guide methadone therapy in this setting, and to summarize associated adverse events...
January 20, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28108669/developmental-differences-in-dynamic-muscle-tendon-behavior-implications-for-movement-efficiency
#8
C M Waugh, T Korff, A J Blazevich
Children perform cyclic motor tasks less efficiently than adults, however the mechanisms underlying such differences are not fully understood. One mechanism that may contribute these age-related differences is a differential contribution of muscles and tendons to a given muscle tendon unit (MTU) excursion. The aims of this study were to a) compare muscle and tendon excursion between children and adults performing vertical hopping, and b) determine if children and adults choose a hopping frequency that maximizes movement efficiency, based on the utilization of energy-saving mechanisms...
January 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28108592/social-class-variation-the-effect-of-the-economic-recession-and-childhood-obesity-at-3-years-of-age-in-ireland
#9
Samira Barbara Jabakhanji, Milena Pavlova, Wim Groot, Fiona Boland, Regien Biesma
BACKGROUND: Many studies have reported a social class gradient within overweight prevalence (1-4). Additionally, cross-country comparisons report high overweight trends and a change in food consumption patterns in countries affected by an economic crisis (5-11). The aim of this study was to assess the association between social class and recession on obesity levels in 3-year-old Irish children. METHODS: The population-based infant cohort of the national Growing Up in Ireland (GUI) study was used...
January 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28108105/performance-of-predictive-equations-specifically-developed-to-estimate-resting-energy-expenditure-in-ventilated-critically-ill-children
#10
Corinne Jotterand Chaparro, Patrick Taffé, Clémence Moullet, Jocelyne Laure Depeyre, David Longchamp, Marie-Hélène Perez, Jacques Cotting
OBJECTIVE: To determine, based on indirect calorimetry measurements, the biases of predictive equations specifically developed recently for estimating resting energy expenditure (REE) in ventilated critically ill children, or developed for healthy populations but used in critically ill children. STUDY DESIGN: A secondary analysis study was performed using our data on REE measured in a previous prospective study on protein and energy needs in pediatric intensive care unit...
January 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28108060/yogurt-consumption-in-infancy-is-inversely-associated-with-atopic-dermatitis-and-food-sensitization-at-5-years-of-age-a-hospital-based-birth-cohort-study
#11
Tetsuo Shoda, Masaki Futamura, Limin Yang, Masami Narita, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: Several studies have suggested that habitual yogurt consumption is associated with favorable outcomes for health issues in children. However, the effects of yogurt consumption on allergic diseases and sensitization in children remain poorly understood. OBJECTIVE: This prospective birth cohort study aimed to investigate for associations between habitual yogurt consumption in infancy and development of allergic diseases/sensitization at 5 years of age...
January 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28108038/the-effect-of-endotracheal-tubes-versus-laryngeal-mask-airways-on-perioperative-respiratory-adverse-events-in-infants-a-randomised-controlled-trial
#12
Thomas F E Drake-Brockman, Anoop Ramgolam, Guicheng Zhang, Graham L Hall, Britta S von Ungern-Sternberg
BACKGROUND: Perioperative respiratory adverse events (PRAE) are the most common critical incidents in paediatric anaesthesia and occur more often in infants. Use of laryngeal mask airways (LMAs) is associated with reduced PRAE compared with endotracheal tubes in older children (>1 year). We aimed to evaluate the effect of these devices on the incidence of PRAE in infants. METHODS: We did a randomised controlled trial at the Princess Margaret Hospital for Children in Perth (WA, Australia) by recruiting infants (aged 0-12 months) undergoing general (with or without regional or local) anaesthesia with anticipated fentanyl dose 1 μg/kg or lower for minor elective surgery...
January 17, 2017: Lancet
https://www.readbyqxmd.com/read/28107572/introduction-of-a-new-paediatric-asthma-guideline-effects-on-asthma-control-levels
#13
S C Hammer, L J H Sonneveld, K D G van de Kant, H J Hendriks, J W Heynens, R Droog, E Dompeling, Q Jöbsis
BACKGROUND: In 2008, a new national paediatric asthma management guideline based on the international Global Initiative for Asthma (GINA) guideline, was launched in the Netherlands. We studied whether asthma control and treatment regimens improved after introduction of the guideline by comparing survey data before and after the guideline introduction. METHODS: Two comparable groups of children (6-16 years) with asthma were included before (2004) and after (2013) the introduction of the guideline...
January 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28107374/combining-social-norms-and-social-marketing-to-address-underage-drinking-development-and-process-evaluation-of-a-whole-of-community-intervention
#14
Sandra C Jones, Kelly Andrews, Kate Francis
Youth alcohol consumption has been steadily declining in Australia, as in other countries; fewer young people are drinking and the age of initiation is increasing. However, young people, their parents and others in their communities continue to believe that adolescent (excessive) drinking is the norm. This perception, and the concurrent misperception that the majority of parents are happy to provide their underage children with alcohol, creates a perceived culture of acceptance of youth alcohol consumption...
2017: PloS One
https://www.readbyqxmd.com/read/28107286/liver-stiffness-measured-by-shear-wave-elastography-for-evaluating-intra-hepatic-portal-hypertension-in-children
#15
Hee Mang Yoon, So Yeon Kim, Kyung Mo Kim, Seak Hee Oh, Gi-Young Ko, Yangsoon Park, Jin Seong Lee, Ah Young Jung, Young Ah Cho
OBJECTIVES: To correlate liver stiffness (LS) and hepatic venous-pressure gradient (HVPG) and to evaluate the diagnostic performance of shear-wave elastography (SWE) for predicting clinically significant portal hypertension in children with suspected liver diseases, in consideration of the reliability criteria. METHODS: We identified 33 SWEs from 32 children who underwent HVPG measurement within two weeks between June 2012 and October 2015. The correlation between LS and HVPG was assessed...
January 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28106934/neuroimaging-the-neural-correlates-of-increased-risk-for-substance-use-disorders-in-attention-deficit-hyperactivity-disorder-a-systematic-review
#16
Vitria Adisetiyo, Kevin M Gray
BACKGROUND/OBJECTIVES: Children with attention-deficit/hyperactivity disorder (ADHD) are nearly three times more likely to develop substance use disorders (SUD) than their typically developing peers. Our objective was to review the existing neuroimaging research on high-risk ADHD (ie, ADHD with disruptive behavior disorders, familial SUD and/or early substance use), focusing on impulsivity as one possible mechanism underlying SUD risk. METHODS: A PubMed literature search was conducted using combinations of the keywords "ADHD," "substance use," "substance use disorder," "SUD," "addiction," "dependence," "abuse," "risk," "brain" "MRI," "imaging" and "neuroimaging...
January 20, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28106914/classification-of-childhood-onset-eating-disorders-a-latent-class-analysis
#17
Leora Pinhas, Dasha Nicholls, Ross D Crosby, Anne Morris, Richard M Lynn, Sloane Madden
This study tested the hypothesis that latent class analysis (LCA) would successfully classify eating disorder (ED) symptoms in children into categories that mapped onto DSM-5 diagnoses and that these categories would be consistent across countries. Childhood onset ED cases were ascertained through prospective active surveillance by the Australian Paediatric Surveillance Unit, the Canadian Paediatric Surveillance Program, and the British Paediatric Surveillance Unit for 36, 24, and 14 months, respectively. Pediatricians and child psychiatrists reported symptoms of any child aged ≤ 12 years with a newly diagnosed restrictive ED...
January 20, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28106792/prevalence-and-correlates-of-metabolic-syndrome-in-chinese-children-the-china-health-and-nutrition-survey
#18
Peige Song, Jinyue Yu, Xinlei Chang, Manli Wang, Lin An
Metabolic syndrome (MetS) is generally defined as a cluster of metabolically related cardiovascular risk factors which are often associated with the condition of insulin resistance, elevated blood pressure, and abdominal obesity. During the past decades, MetS has become a major public health issue worldwide in both adults and children. In this study, data from the China Health and Nutrition Surveys (CHNS) was used to assess the prevalence of MetS based on both the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) guidelines and the International Diabetes Federation (IDF) criteria, and to evaluate its possible correlates...
January 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28106692/use-of-resorbable-fixation-system-in-pediatric-facial-fractures
#19
Frankie K Wong, Saleigh Adams, Donald A Hudson, Wayne Ozaki
INTRODUCTION: Resorbable fixation system (RFS) is an alternative to titanium in open reduction and internal fixation of pediatric facial fractures. METHODS: This study retrospectively reviewed all medical records in a major metropolitan pediatric hospital in Cape Town, South Africa from September 2010 through May 2014. Inclusion criteria were children under the age of 13 with facial fractures who have undergone open reduction and internal fixation using RFS. Intraoperative and postoperative complications were reviewed...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28105068/overdiagnosis-of-mental-disorders-in-children-and-adolescents-in-developed-countries
#20
REVIEW
Eva Charlotte Merten, Jan Christopher Cwik, Jürgen Margraf, Silvia Schneider
During the past 50 years, health insurance providers and national registers of mental health regularly report significant increases in the number of mental disorder diagnoses in children and adolescents. However, epidemiological studies show mixed effects of time trends of prevalence of mental disorders. Overdiagnosis in clinical practice rather than an actual increase is assumed to be the cause for this situation. We conducted a systematic literature search on the topic of overdiagnosis of mental disorders in children and adolescents...
2017: Child and Adolescent Psychiatry and Mental Health
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