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Interstitial Ling Disease

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https://www.readbyqxmd.com/read/28893174/antiproliferative-factor-apf-binds-specifically-to-sites-within-the-cytoskeleton-associated-protein-4-ckap4-extracellular-domain
#1
Burzin Chavda, Jun Ling, Thomas Majernick, Sonia Lobo Planey
BACKGROUND: Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis-a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelial cells and cancer cells in vitro, presumably by binding to its cellular receptor, cytoskeleton associated-protein 4 (CKAP4); however, the biophysical interaction of APF with CKAP4 has not been characterized previously. In this study, we used surface plasmon resonance (SPR) to explore the binding kinetics of the interaction of APF and as-APF (a desialylated APF analogue with full activity) to CKAP4...
September 11, 2017: BMC Biochemistry
https://www.readbyqxmd.com/read/28767184/antithrombin-iii-prevents-progression-of-chronic-kidney-disease-following-experimental-ischaemic-reperfusion-injury
#2
Jianyong Yin, Feng Wang, Yiwei Kong, Rui Wu, Guangyuan Zhang, Niansong Wang, Ling Wang, Zeyuan Lu, Mingyu Liang
Acute kidney disease (AKI) leads to increased risk of progression to chronic kidney disease (CKD). Antithrombin III (ATIII) is a potent anticoagulant with anti-inflammatory properties, and we previously reported that insufficiencies of ATIII exacerbated renal ischaemia-reperfusion injury (IRI) in rats. In this study, we examined the characteristic of AKI-CKD transition in rats with two distinct AKI models. Based on our observation, left IRI plus right nephrectomy (NX-IRI) was used to determine whether ATIII had therapeutic effects in preventing CKD progression after AKI...
August 2, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28565750/myocardial-fibrosis-in-congenital-and-pediatric-heart-disease
#3
Jing Tian, Xinjiang An, Ling Niu
Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying cause of fibrotic heart disease. There are four different types of cardiac fibrosis, including, reactive interstitial fibrosis, replacement fibrosis, infiltrative interstitial fibrosis and endomyocardial fibrosis...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28399902/efficacy-and-safety-of-everolimus-in-combination-with-trastuzumab-and-paclitaxel-in-asian-patients-with-her2-advanced-breast-cancer-in-bolero-1
#4
Masakazu Toi, Zhimin Shao, Sara Hurvitz, Ling-Ming Tseng, Qingyuan Zhang, Kunwei Shen, Donggeng Liu, Jifeng Feng, Binghe Xu, Xiaojia Wang, Keun Seok Lee, Ting Ying Ng, Antonia Ridolfi, Florence Noel-Baron, Francois Ringeisen, Zefei Jiang
BACKGROUND: The current exploratory analysis was performed to evaluate the efficacy and safety of everolimus for treatment of human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer in the Asian subset of patients in the BOLERO-1 trial. METHODS: Postmenopausal women with HER2+ advanced breast cancer, who had not received systemic therapy for advanced disease, were randomized 2:1 to receive everolimus or placebo, plus trastuzumab and paclitaxel...
April 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28073593/integrative-cardiopulmonary-ultrasound-for-interstitial-lung-disease-assessment-correlation-between-lung-ultrasound-performance-and-cardiac-involvement
#5
Wei-Wei Zhu, Yi-Dan Li, Hong Li, Xiu-Zhang Lu, Ling-Yun Kong, Xiao-Guang Ye, Qi-Zhe Cai, Lan-Lan Sun, Wei Jiang, Li Wang
The aims of this study were to apply integrative cardiopulmonary ultrasound (thoracic ultrasound) to the evaluation of patients with interstitial lung disease (ILD) and to determine the relationship between lung ultrasound signs and echocardiographic parameters such as systolic pulmonary artery pressure (SPAP) and various right ventricular parameters. ILD patients and healthy controls underwent lung ultrasound (LUS) and echocardiographic tests. In addition to traditional echocardiographic parameters, right ventricular free wall longitudinal strain (RVLS_FW) was measured using 2-D speckle-tracking echocardiography...
April 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27809611/lung-ultrasonography-to-diagnose-pulmonary-hemorrhage-of-the-newborn
#6
Xiao-Ling Ren, Wei Fu, Jing Liu, Ying Liu, Rong-Ming Xia
OBJECTIVES: This study was aimed to investigate the application of lung ultrasound for the diagnosis of pulmonary hemorrhage of the newborn (PHN). METHODS: From July 2013 to June 2016, 157 neonates were enrolled in the study. They were divided into two groups: a study group of 57 neonates, who were diagnosed with PHN according to their medical history, clinical manifestations and chest X-ray findings, and a control group of 100 neonates with no lung disease. All subjects underwent bedside lung ultrasound in a quiet state in a supine, lateral or prone position, performed by a single expert physician...
November 22, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27677327/losartan-reduces-ensuing-chronic-kidney-disease-and-mortality-after-acute-kidney-injury
#7
Shun-Yang Cheng, Yu-Hsiang Chou, Fang-Ling Liao, Chi-Chun Lin, Fan-Chi Chang, Chia-Hao Liu, Tao-Min Huang, Chun-Fu Lai, Yu-Feng Lin, Vin-Cent Wu, Tzong-Shinn Chu, Ming-Shiou Wu, Shuei-Liong Lin
Acute kidney injury (AKI) is an important risk factor for incident chronic kidney disease (CKD). Clinical studies disclose that ensuing CKD progresses after functional recovery from AKI, but the underlying mechanisms remain illusive. Using a murine model representing AKI-CKD continuum, we show angiotensin II type 1a (AT1a) receptor signaling as one of the underlying mechanisms. Male adult CD-1 mice presented severe AKI with 20% mortality within 2 weeks after right nephrectomy and left renal ischemia-reperfusion injury...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27546509/-research-progress-on-the-function-of-epithelial-tight-junction
#8
REVIEW
Xin Cong, Yan Zhang, Guang-Yan Yu, Li-Ling Wu
Tight junctions (TJs) are widely expressed in the most apical portion of both epithelial and endothelial cell-cell interactions, serving as a structural and functional basis for material transport through the paracellular pathway. TJs are multi-protein complex composed of transmembrane and cytoplasmic proteins. TJs constitute pores allowing materials with specific size and electrical charge to pass through the paracellular pathway, which is so called "barrier" function. Besides, TJs also separate the lumen and interstitial space of epithelium and endothelium by the function of "fence"...
August 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27492484/treatment-with-cytokine-thymic-stromal-lymphopoietin-short-hairpin-rna-substantially-reduces-tgf-%C3%AE-1-induced-interstitial-cellular-fibrosis
#9
Pei-Fang Hsieh, Shu-Fen Liu, Tsung-Jen Hung, Chien-Ya Hung, Guo-Zheng Liu, Lea-Yea Chuang, Mei-Fen Chen, Jue-Long Wang, Ming-Der Shi, Chen Hung Hsu, Yow-Ling Shiue, Yu-Lin Yang
Thymic stromal lymphopoietin (TSLP) has previously been linked to allergic inflammatory diseases, and tissue fibrosis and organ dysfunction may also arise from such inflammation. It remains unclear, however, whether TSLP plays any role in the occurrence of renal fibrosis, so this study investigated that possibility. An in vitro fibrosis model was established by treating normal rat kidney fibroblast (NRK-49F) cells with transforming growth factor-β1 (TGF-β1), after which the levels of various fibrogenic markers (e...
September 10, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27413418/hydrogen-sulfide-mitigates-kidney-injury-in-high-fat-diet-induced-obese-mice
#10
Dongdong Wu, Biao Gao, Mengling Li, Ling Yao, Shuaiwei Wang, Mingliang Chen, Hui Li, Chunyan Ma, Ailing Ji, Yanzhang Li
Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease. Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes. However, whether H2S is able to mitigate kidney injury induced by obesity in mice remains unclear. In this study, we demonstrated that H2S significantly reduced the accumulation of lipids in the kidneys of high fat diet- (HFD-) induced obese mice. The results of hematoxylin and eosin, periodic acid-Schiff, and Masson's trichrome staining showed that H2S ameliorated the kidney structure, decreased the extent of interstitial injury, and reduced the degree of kidney fibrosis in HFD-induced obese mice...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27404002/risk-factors-and-outcomes-of-nontuberculous-mycobacterial-disease-among-rheumatoid-arthritis-patients-a-case-control-study-in-a-tb-endemic-area
#11
Tsai-Ling Liao, Chin-Fu Lin, Yi-Ming Chen, Hung-Jen Liu, Der-Yuan Chen
Increasing evidence indicates that the risk of nontuberculous mycobacteria (NTM) disease is elevated in patients with rheumatoid arthritis (RA). However, the risk factors and outcomes for NTM disease among RA patients remain unclear. We conducted a case-control study and estimated odds ratios (ORs) for RA patients with NTM disease according to comorbidities and anti-rheumatic medications by using conditional logistic regression. Prior tuberculosis history (adjusted OR (aOR) =5.58, p < 0.001), hypertension (aOR = 2...
July 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27149370/plasma-surfactant-protein-d-matrix-metalloproteinase-7-and-osteopontin-index-distinguishes-idiopathic-pulmonary-fibrosis-from-other-idiopathic-interstitial-pneumonias
#12
Eric S White, Meng Xia, Susan Murray, Rachel Dyal, Candace M Flaherty, Kevin R Flaherty, Bethany B Moore, Ling Cheng, Tracy J Doyle, Julian Villalba, Paul F Dellaripa, Ivan O Rosas, Jonathan D Kurtis, Fernando J Martinez
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease (ILD) characterized by abnormal extracellular matrix (ECM) remodeling. We hypothesized that ECM remodeling might result in a plasma profile of proteins specific for IPF that could distinguish patients with IPF from other idiopathic ILDs. OBJECTIVES: To identify biomarkers that might assist in distinguishing IPF from non-IPF ILD. METHODS: We developed a panel of 35 ECM, ECM-related, and lung-specific analytes measured in plasma from 86 patients with IPF (derivation cohort) and in 63 patients with IPF (validation cohort)...
November 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27132438/-effect-of-prone-position-ventilation-on-respiratory-mechanics-and-prognosis-in-patients-with-acute-respiratory-distress-syndrome-concurrent-with-interstitial-lung-disease
#13
Qingwen Sun, Mangui Zhu, Yin Xi, Yuheng Yu, Xuesong Liu, Ling Sang, Yonghao Xu, Sibei Chen, Lingbo Nong, Weiqun He, Yuanda Xu, Yimin Li, Xiaoqing Liu
OBJECTIVE: To explore the effect of prone position ventilation (PPV) on respiratory mechanics and prognosis in patients with acute respiratory distress syndrome (ARDS) concurrent with interstitial lung disease (ILD). METHODS: The data of 36 severe ARDS patients admitted to Department of Critical Care Medicine of the First Affiliated Hospital of Guangzhou Medical University from February 2013 to January 2015, were retrospectively analyzed. They were then divided into two groups according to the presence of ILD or not...
October 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/26988682/-upregulated-notch1-expression-promotes-bone-morphogenetic-protein-2-4-expression-of-calcified-human-heart-valve-interstitial-cells
#14
Q Y Ling, J Liu, B D Xu, T Wu, T Ye, G J Zong
OBJECTIVE: To observe the protein expression of Notch1 in the cultured calcified human heart valve interstitial cells (hVICs) in vitro and related mechanisms. METHODS: hVICs were divided into two groups: control hVICs were cultured in conventional media for 14 days and calcified hVICs were cultured with calcification inducers: β-glycerophosphate (500 μl), ascorbic acid (200 μl), dexamethasone(100 μl) for 7 days. The calcified hVICs were further divided into calcified hVICs group and inhibited calcified hVICs by adding specific Notch1 inhibitor DAPT (50 μmol/L(4 μl/hole))groups and cultured for another 7 days...
March 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/26574480/involvement-of-the-hippo-pathway-in-regeneration-and-fibrogenesis-after-ischaemic-acute-kidney-injury-yap-is-the-key-effector
#15
Jing Xu, Pei-Xue Li, Jun Wu, Yi-Jun Gao, Meng-Xin Yin, Ye Lin, Ming Yang, Dong-Ping Chen, Hai-Peng Sun, Zeng-Bo Liu, Xiang-Chen Gu, Hong-Ling Huang, Li-Li Fu, Hui-Min Hu, Liang-Liang He, Wen-Qing Wu, Zhao-Liang Fei, Hong-Bin Ji, Lei Zhang, Chang-Lin Mei
Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway components were evaluated in complete/incomplete repair of I/R (ischaemia/reperfusion) AKI rat models, HK-2 cells and AKI human renal biopsy samples. We found that the expression levels of the Hippo pathway components changed dynamically during kidney regeneration and fibrogenesis in rat models of I/R-induced AKI and human renal biopsy samples...
March 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/26356699/the-efficacy-and-safety-of-chemotherapy-in-patients-with-nonsmall-cell-lung-cancer-and-interstitial-lung-disease-a-prisma-compliant-bayesian-meta-analysis-and-systematic-review
#16
Yu Jie Chen, Ling Xiao Chen, Mei Xiang Han, Tian Song Zhang, Zhi Rui Zhou, Dian Sheng Zhong
Chemotherapy plays a critical and venturous role against the co-morbidity of nonsmall cell lung cancer and interstitial lung disease (NSCLC-ILD).We performed a Bayesian meta-analysis and systematic review to evaluate the safety and efficacy of the chemotherapy in NSCLC-ILD patients.EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, and clinicaltrials.gov (up to January 2015).We included all study designs except case reports, all studies with NSCLC-ILD patients and all the possible chemotherapy regimens...
September 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26251179/metabolomics-analysis-reveals-the-association-between-lipid-abnormalities-and-oxidative-stress-inflammation-fibrosis-and-nrf2-dysfunction-in-aristolochic-acid-induced-nephropathy
#17
Ying-Yong Zhao, Hui-Ling Wang, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin, Nosratola D Vaziri
Alternative medicines are commonly used for the disease prevention and treatment worldwide. Aristolochic acid (AAI) nephropathy (AAN) is a common and rapidly progressive interstitial nephropathy caused by ingestion of Aristolochia herbal medications. Available data on pathophysiology and molecular mechanisms of AAN are limited and were explored here. SD rats were randomized to AAN and control groups. AAN group was treated with AAI by oral gavage for 12 weeks and observed for additional 12 weeks. Kidneys were processed for histological evaluation, Western blotting, and metabolomics analyses using UPLC-QTOF/HDMS...
August 7, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26109848/cardioprotection-against-ischemia-reperfusion-injury-by-qishenyiqi-pill%C3%A2-via-ameliorate-of-multiple-mitochondrial-dysfunctions
#18
Jing Rui Chen, Jing Wei, Ling Yan Wang, Yan Zhu, Lan Li, Mary Akinyi Olunga, Xiu Mei Gao, Guan Wei Fan
AIM: To investigate the potential cardioprotective effects of QiShenYiQi Pill(®) (QSYQ) on myocardial ischemia/reperfusion (I/R) injury through antioxidative stress and mitochondrial protection. METHODS AND RESULTS: Sprague Dawley rats were pretreated with QSYQ or saline for 7 days and subjected to ischemia (30 minutes occlusion of the left anterior descending coronary artery) and reperfusion (120 minutes). Cardiac functions were evaluated by echocardiogram and hemodynamics...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26042668/mefunidone-attenuates-tubulointerstitial-fibrosis-in-a-rat-model-of-unilateral-ureteral-obstruction
#19
Chunyan Liu, Wenjuan Mei, Juan Tang, Qiongjing Yuan, Ling Huang, Miaomiao Lu, Lin Wu, Zhangzhe Peng, Jie Meng, Huixiang Yang, Hong Shen, Ben Lv, Gaoyun Hu, Lijian Tao
BACKGROUND: Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new compound which could effectively inhibit the proliferation of renal fibroblasts in vitro. However, the overall effect of Mefunidone in renal fibrosis remains unknown. METHODS: Sprague-Dawley rats were randomly divided intro 6 groups: sham operation, unilateral ureteral obstruction (UUO), UUO/Mefunidone (25, 50, 100mg/kg/day) and UUO/PFD (500mg/kg/day)...
2015: PloS One
https://www.readbyqxmd.com/read/26035627/the-protective-mechanism-of-fluorofenidone-in-renal-interstitial-inflammation-and-fibrosis
#20
Yiting Tang, Fangfang Zhang, Ling Huang, Qiongjing Yuan, Jiao Qin, Bingxin Li, Nasui Wang, Yanyun Xie, Linghao Wang, Wei Wang, Kevin Kwan, Zhangzhe Peng, Gaoyun Hu, Jing Li, Lijian Tao
BACKGROUND: Deregulated inflammation has been implicated in the development of renal interstitial fibrosis and progressive renal failure. Previous work has established that fluorofenidone, a pyridone agent, attenuates renal fibrosis. However, the mechanism by which fluorofenidone prevents renal fibrosis remains unclear. The aim of this study was to investigate the in vivo effects of fluorofenidone on unilateral ureteral obstruction-induced fibrosis and the involved molecular mechanism in mouse peritoneal macrophages...
September 2015: American Journal of the Medical Sciences
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