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https://www.readbyqxmd.com/read/29677262/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#1
Alex Tsodikov, Roman Gulati, Ruth Etzioni
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677261/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#2
Shinkan Tokudome, Ryosuke Ando, Shuji Hashimoto
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677260/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#3
Stuart G Baker
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677259/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#4
Philip C Prorok, Anthony B Miller
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677258/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#5
Join Y Luh, Steven E Finkelstein, Jeff M Michalski, Howard Sandler Md
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677257/reconciling-the-effects-of-screening-on-prostate-cancer-mortality-in-the-erspc-and-plco-trials
#6
Philippe Autier, Peter Boyle
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29676909/-18-f-positron-emitting-trimethine-cyanine-fluorescent-contrast-for-image-guided-prostate-cancer-management
#7
Harikrishna Kommidi, Hua Guo, Fuad Nurili, Yogindra Vedvyas, Moonsoo M Jin, Timothy D McClure, Behfar Ehdaie, Haluk B Sayman, Oguz Akin, Omer Aras, Richard Ting
[18/19 F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19 F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19 F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18 F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells...
April 20, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29676828/%C3%AE-arrestin1-medieated-inhibition-of-foxo3a-contributes-the-prostate-cancer-cell-growth-in-vitro-and-in-vivo
#8
Zhenzhen Kong, Tuo Deng, Mengping Zhang, Zhijian Zhao, Yang Liu, Lianmin Luo, Chao Cai, Wenqi Wu, Xiaolu Duan
Recently, β-arrestin1 has been indicated as a prostate cancer promoter via promoting cell proliferation and epithelial to mesenchymal transition (EMT), but its underlying mechanism remains unclear. Here, our data revealed that β-arrestin1 could promote cell growth via inhibiting the transcriptional activity and expression of FOXO3a in prostate cancer cells in vitro and in vivo. In detail, we found that β-arrestin1 could promote the cell and tumor growth of prostate cancer, and β-arrestin1 expression represented a negative correlation with FOXO3a expression but not FOXO1 expression in prostate cancer cell lines and tissues...
April 20, 2018: Cancer Science
https://www.readbyqxmd.com/read/29676345/bilateral-subcapsular-orchiectomy-versus-bilateral-total-orchiectomy-comparison-of-the-quality-of-life-post-orchiectomy
#9
Dubem Ejikeme Orakwe, Kehinde Habeeb Tijani, Emmauel Ajibola Jeje, Moses Adebisi Ogunjimi, Wale Ojewola Rufus, Taiwo Opeyemi Alabi
Objective: Bilateral subcapsular orchiectomy (BSO) is said to be more aesthetic and psychologically satisfying when compared to bilateral total orchiectomy (BTO). This study compared the quality of life (QoL) of men with advanced prostate cancer who had BTO to those who had BSO, with an emphasis on their perception of self or identity as a man. Subjects and Methods: Sixty-one patients with advanced prostate cancer opting for bilateral orchiectomy were recruited...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676063/development-and-internal-validation-of-a-side-specific-multiparametric-mri-based-nomogram-for-the-prediction-of-extracapsular-extension-of-prostate-cancer
#10
Alberto Martini, Akriti Gupta, Sara C Lewis, Shivaram Cumarasamy, Kenneth G Haines, Alberto Briganti, Francesco Montorsi, Ash K Tewari
OBJECTIVES: To develop a nomogram for predicting side-specific extracapsular extension (ECE) for planning nerve sparing radical prostatectomy (NSRP). MATERIALS AND METHODS: We retrospectively analyzed data from 561 patients who underwent robot-assisted radical prostatectomy between February 2014 and October 2015. To develop a side-specific predictive model, we considered the prostatic lobes separately. Four variables were included: PSA, highest ipsilateral biopsy Gleason grade, highest ipsilateral percentage core involvement and ECE on multiparametric MRI (mpMRI)...
April 19, 2018: BJU International
https://www.readbyqxmd.com/read/29675653/medical-student-exposure-to-cancer-patients-whilst-on-clinical-placement-a-retrospective-analyses-of-clinical-log-books
#11
Darren L Starmer
In Australia, one in two men and one in three women will be diagnosed with cancer by the age of 85. Several studies have demonstrated a decline in the number of medical graduates having examined cancer patients during their training. The aim of this study was to evaluate the exposure of medical students to cancer patients during clinical placements. Eighty-eight logbooks (response rate = 24.75%) containing 9430 patients were analysed. A total of 829 patients (8.79%) had a diagnosis of cancer. Most cancer patients were seen on surgical placements, whilst general practice placements returned the lowest numbers...
April 19, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29675529/zinc-ion-mediated-self-assembly-of-forky-peptides-for-prostate-cancer-specific-drug-delivery
#12
Mingtao Tao, Keming Xu, Suyun He, Hongmei Li, Li Zhang, Xuefang Luo, Wenying Zhong
A novel forky peptide was designed and synthesized. The peptide self-assembled into supramolecular hydrogels triggered by zinc ions (ZIs). The hydrogels were designed for a drug delivery system (DDS), loaded with docetaxel and applied for the therapy of prostate cancer. In this research, we have discussed the response mechanism and evaluated the anticancer effect of the DDS.
April 20, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#13
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29674995/serum-steroid-ratio-profiles-in-prostate-cancer-a-new-diagnostic-tool-toward-a-personalized-medicine-approach
#14
Adriana Albini, Antonino Bruno, Barbara Bassani, Gioacchino D'Ambrosio, Giuseppe Pelosi, Paolo Consonni, Laura Castellani, Matteo Conti, Simone Cristoni, Douglas M Noonan
Background: Serum steroids are crucial molecules altered in prostate cancer (PCa). Mass spectrometry (MS) is currently the elected technology for the analysis of steroids in diverse biological samples. Steroids have complex biological pathways and stoichiometry and it is important to evaluate their quantitative ratio. MS applications to patient hormone profiling could lead to a diagnostic approach. Methods: Here, we employed the Surface Activated Chemical Ionization-Electrospray-NIST (SANIST) developed in our laboratories, to obtain quantitative serum steroid ratio relationship profiles with a machine learning Bayesian model to discriminate patients with PCa...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29674723/steap2-knockdown-reduces-the-invasive-potential-of-prostate-cancer-cells
#15
Stephanie E A Burnell, Samantha Spencer-Harty, Suzie Howarth, Owen Bodger, Howard Kynaston, Claire Morgan, Shareen H Doak
Six-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer progression. This study aimed to establish the functional role of STEAP2 in prostate tumourigenesis and evaluate if its knockdown resulted in reduced invasive potential of prostate cancer cells. PC3 and LNCaP cells were transfected with STEAP2 siRNA and proliferation, migration, invasion and gene expression analyses were performed...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674422/a-perspective-on-the-evolving-story-of-psma-biology-and-psma-based-imaging-and-endoradiotherapeutic-strategies
#16
Denise S O'Keefe, Dean J Bacich, Steve S Huang, Warren D Heston
We will review the evolution of knowledge of the biology of Prostate-Specific Membrane Antigen (PSMA) and how the translation to therapy has also developed. The usual key to discovery is a realistic model for experimentation and hypothesis testing. This is especially true for the prostate where the human prostate differs significantly from that of other often used species for research models. We will emphasize the genetic characterization of PSMA, The nature of the PSMA protein and its role as a carboxypeptidase, with differing important substrates and products in different tissues...
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29674390/consumption-of-sugars-sugary-foods-and-sugary-beverages-in-relation-to-adiposity-related-cancer-risk-in-the-framingham-offspring-cohort-1991-2013
#17
Nour Makarem, Elisa V Bandera, Yong Lin, Paul Jacques, Richard B Hayes, Niyati Parekh
BACKGROUND: Higher sugar consumption may increase cancer risk by promoting insulin-glucose dysregulation, oxidative stress, hormonal imbalances, and excess adiposity. This prospective study investigates the association between dietary sugars(fructose and sucrose) and sugary foods and beverages in relation to combined and site-specific (breast, prostate, colorectal) adiposity-associated cancers. METHODS: The analytic sample consisted of 3,184 adults, aged 26-84y, from the Framingham Offspring cohort...
April 19, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29674122/4-fluorobenzaldehyde-limonene-based-thiosemicarbazone-induces-apoptosis-in-pc-3-human-prostate-cancer-cells
#18
Bruna Dos Santos Rodrigues, Renato Ivan de Ávila, Polyana Lopes Benfica, Ludmila Pires Bringel, Cecília Maria Alves de Oliveira, Fábio Vandresen, Cleuza Conceição da Silva, Marize Campos Valadares
AIMS: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. MAIN METHODS: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry...
April 16, 2018: Life Sciences
https://www.readbyqxmd.com/read/29674118/germline-variant-in-hsd3b1-1245-a-c-and-response-to-abiraterone-acetate-plus-prednisone-in-men-with-new-onset-metastatic-castration-resistant-prostate-cancer
#19
Andrew W Hahn, David M Gill, Roberto H Nussenzveig, Austin Poole, Jim Farnham, Lisa Cannon-Albright, Neeraj Agarwal
BACKGROUND: The HSD3B1 gene encodes the enzyme 3β-hydroxysteroid dehydrogenase-1 (3βHSD1), which catalyzes adrenal androgen precursors into dihydrotestosterone, the most potent androgen. Recently, the HSD3B1 (1245C) variant was shown to predict shorter duration of response to androgen deprivation therapy with medical or surgical castration in the setting of castration-sensitive prostate cancer (CSPC). The HSD3B1 (1245C) variant also predicts longer duration of response to ketoconazole in men with castration-resistant prostate cancer (CRPC)...
March 27, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29673946/subtyping-the-risk-of-intermediate-risk-prostate-cancer-for-active-surveillance-based-on-adverse-pathology-at-radical-prostatectomy
#20
Hiten D Patel, Mohit Gupta, Jeffrey J Tosoian, H Ballentine Carter, Alan W Partin, Jonathan I Epstein
INTRODUCTION: Intermediate-risk (IR) prostate cancer is a heterogenous classification with favorable criteria proposed based on men treated with radiation therapy but uncertain application to active surveillance. We quantified the rate of adverse surgical pathology and implications for survival for patients with favorable IR (FIR) compared to low-risk (LR) prostate cancer. MATERIALS AND METHODS: A comparative cohort study of men with prostate cancer (2009-2013) undergoing radical prostatectomy was conducted in the National Cancer Database...
April 16, 2018: Journal of Urology
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