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Erection dysfunction

L Zhang, H-Y Zhang, F-C Huang, Q Huang, C Liu, J-R Li
OBJECTIVE: We investigated the clinical value of alprostadil combined with the α-lipoic acid in treating type 2 diabetes mellitus with erectile dysfunction (DMED). PATIENTS AND METHODS: We selected a total of 76 cases of patients who were admitted to endocrinology department of our hospital from June 2014 to June 2015 and diagnosed as DMED, and the average age was (46.7 ± 7.2) years old, average course of diabetes mellitus was (6.2 ± 2.8) years and average body mass index was (25...
September 2016: European Review for Medical and Pharmacological Sciences
Hendt P Versteegh, Navroop S Johal, Ivo de Blaauw, Michael P Stanton
PURPOSE: There is a paucity of recent evidence regarding long-term urological and sexual outcomes following surgery for Hirschsprung disease (HD). We aimed to undertake a systematic review of all HD literature to define these outcomes. MATERIALS AND METHODS: A systematic literature search was conducted on studies from 1966 to 2014. Relevant articles were assessed for urological/sexual operative complications and functional sequelae. Studies were analysed in qualitative (Rangel score) and quantitative syntheses...
September 30, 2016: Journal of Pediatric Urology
Giuseppe Sangiorgi, Riccardo Colantonio, Gabriele Antonini, Antonio Savino, Massimiliano Sperandio
Erectile dysfunction (ED) is defined as the inability to get and maintain a sufficient erection to ensure an acceptable sexual activity for the subject and the partner. Although ED does not represent per se a serious disease, it carries a notable and severe influence on quality of life, with significant implications on familiar and social relationship; DE may cause depression, shame, impairment of personal esteem and relational problems. Among many possible etiologies of ED, atherosclerotic disease of penile arteries represents one of the most frequent causes, so it should always be looked for in patients with multiple risk factors for cardiovascular disease or an established coronary or peripheral artery disease...
October 2016: Giornale Italiano di Cardiologia
Fabio Pezzoni, Fabrizio Ildefonso Scroppo
OBJECTIVES: In 2013 the International Society for Sexual Medicine(ISSM) published the guidelines regarding the standard operating procedure (SOP) for penile duplex Doppler ultrasound (PDDU). Although ISSM-SOP have given important strides in reducing interobserver variability in PDDU by procedural protocol and parameters these guidelines do not address the anatomic location along the penis at which hemodynamic measurements have to be done. In our opinion a "double sampling" may be interesting to detect the arteriogenic or venogenic nature of the erectile dysfunction (ED)...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
Paul Neuville, Nicolas Morel-Journel, Delphine Maucourt-Boulch, Alain Ruffion, Philippe Paparel, Jean-Etienne Terrier
INTRODUCTION: The creation of a neophallus is a complex surgery that must meet functional and esthetic requirements. It is a long and demanding surgical process whose final stage consists of the implantation of a rigid or inflatable material that can be used to reproduce an erection. Data in the literature are scarce, with only the pioneering series present, which includes the use of the first devices and techniques. AIM: To report the outcome of patients with phalloplasty after implantation of erectile implants using standardized surgical techniques and the use of recent prosthesis types with or without a vascular graft...
September 29, 2016: Journal of Sexual Medicine
Bogdan Pajovic, Antonio Dimitrovski, Nikola Fatic, Milos Malidzan, Marko Vukovic
The aim of this study is to investigate changes in the vascular system and hemodynamics between patients with organic erectile dysfunction (ED) (DM type I and II), as well as to compare the quality of sexual life between those two groups after the treatment with vacuum erection device (VED). Study enrolled 50 males with DM, aged from 35 to 67 years, who have attended the urologic clinic due to inability to attain and maintain an erection of the penis sufficient to permit satisfactory sexual intercourse. Patients were using VED and six months later were assessed for therapy results...
October 1, 2016: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Ömer Barış Yücel, Emre Salabaş, Bahadır Ermeç, Ateş Kadıoğlu
INTRODUCTION: Priapism, taking its name from God Priapus, is total or partial erection lasting longer than 4 hours independent of sexual stimulus and can result in erectile dysfunction. There are three subtypes of priapism. AIM: To review the three subtypes of priapism, their pathophysiology, current treatment options, and complications. METHODS: The literature including priapism guidelines, review articles, and current trial studies was reviewed and the priapism type of God Priapus was investigated according to the mythology...
September 26, 2016: Sexual Medicine Reviews
H Kenmogne, B Koloko, C Hambe, J Domkam, M Ngaha Njila, E Bend, P Oundoum Oundoum, D Massoma Lembè, T Dimo
Several lines say that a number of natural products, mostly plant based, have been claimed to cure male sexual dysfunction. One of such botanicals is Carpolobia alba G. Don which is used in Cameroon to treat erectile dysfunction and related male sexual debilities. However, the traditional claim has not been scientifically tested. Thirty adult male rats (five groups of six animals) were orally treated daily with distilled water, sildenafil citrate (positive control), 75, 150, 300 mg/kg of C. alba G. Don roots aqueous extract...
October 2016: Andrologia
Igor Voznesensky, Kenneth J DeLay, Wayne J G Hellstrom
Cardiovascular disease (CVD) and erectile dysfunction (ED) are two disease processes that affect millions of men. CVD and ED are increasingly recognized as sharing a common pathophysiologic origin. As the nature of this relationship continues to be elucidated, there is growing interest in developing a therapy to effectively target both processes. While researchers have largely focused on phosphodiesterase-5 inhibitors (PDE5Is), the established first-line therapy for ED, newer ED drugs, designed based on better understanding of the physiology of erection, may also show promise...
October 8, 2016: Expert Opinion on Pharmacotherapy
Lucie Chochina, Florian Naudet, Isabelle Bonan, Clément Chehensse, Mireille Damphousse, Andrea Manunta, François Giuliano
OBJECTIVE: To review the efficacy of intracavernous injections (ICI) in spinal cord injured (SCI) men and to identify prognostic factors affecting the efficacy of ICI in this population. MATERIAL/PATIENTS AND METHODS: Systematic review of the literature using 5 databases. Articles published up to november 2014 using the keywords: alprostadil; papaverine; moxisylyte; alpha-blocking agent; phentolamine; intracavernous injection; spinal cord injuries; paraplegia; quadriplegia; erectile dysfunction; were included...
September 2016: Annals of Physical and Rehabilitation Medicine
Marcel D Waldinger
For many decades it has been thought that lifelong premature ejaculation (PE) is only characterized by persistent early ejaculations. Despite enormous progress of in vivo animal research, and neurobiological, genetic and pharmacological research in men with lifelong PE, our current understanding of the mechanisms behind early ejaculations is far from complete. The new classification of PE into four PE subtypes has shown that the symptomatology of lifelong PE strongly differs from acquired PE, subjective PE and variable PE...
August 2016: Translational Andrology and Urology
Brian Le, Kevin McVary, Kevin McKenna, Alberto Colombo
OBJECTIVE: To compare a novel Nickel-Titanium (Ni-Ti) shape memory alloy (SMA) penile prosthesis of our own design to commercially available prostheses using a format similar to mechanical testing done at major penile prosthesis manufacturers. We evaluated the mechanical parameters of commercially available penile prostheses and used this information to guide the development of the nickel-titanium based physiologic penile prosthesis that expands and becomes erect with a small amount of heat applied...
September 14, 2016: Urology
Petros V Vlastarakos, Thomas P Nikolopoulos
BACKGROUND: Phosphodiesterase-5 (PDE-5) inhibitors enhance penile erection and have gained popularity not only for erectile dysfunction, but also in recreational settings. Nevertheless, adverse effects have been associated with their use, with nasal bleeding among them. PDE-5 inhibitor action is materialized through the inhibition of the cyclic guanosine monophosphate (cGMP) enzyme. cGMP is present at several sites of the human body in addition to the corpus cavernosum, leading to the adverse effects associated with its nonselective inhibition...
September 10, 2016: Journal of Emergency Medicine
Matthew Lee Smith, Heather Honoré Goltz, Audry S Motlagh, SangNam Ahn, Caroline D Bergeron, Marcia G Ory
PURPOSE: This study aims to identify socio-demographic and health behavior factors associated with cardiovascular disease (CVD) diagnosis and patient-physician communication concerning sexual issues among older Veterans. METHODS: Cross-sectional data were collected from 635 male Veterans over age 55 years as part of the 2010 National Social Life, Health and Aging Project, a nationally-representative, population-based study of community-dwelling older Americans. Two independent logistic regression analyses were performed...
October 2016: Maturitas
S Frees, P Rubenwolf, C Ziesel, J Faber, P Gutjahr, A Grossmann, J W Thüroff, R Stein
INTRODUCTION: Rhabdomyosarcoma (RMS) accounts for 5% of all pediatric tumors; 15-20% of these tumors are located in the urogenital tract, mostly originating from the prostate or bladder. In the light of the steadily improving prognosis for patients with RMS through interdisciplinary-multimodal study protocols with 60-70% long-term survivors, non oncological aspects such as erectile function (EF) have become increasingly important. The aim of this study was to evaluate EF in patients having undergone treatment for RMS of the bladder and prostate...
August 1, 2016: Journal of Pediatric Urology
Rama Firmanto, Gampo A Irdam, Irfan Wahyudi
AIM: this meta-analysis study will evaluate the incidence of urethral stricture as a successfull parameter in the management of PFUI through early realignment, compared with delayed urethroplasty. Long-term complications such as erectile dysfunction and incontinence on both methods will also be evaluated. METHODS: online literature was sourced from Pubmed, Embase, Cochrane, and Google Scholar. The incidence of stricture was evaluated from the entire study group of ER and DU...
April 2016: Acta Medica Indonesiana
Ulf Simonsen, Simon Comerma-Steffensen, Karl-Erik Andersson
The currently recommended first-line treatments of erectile dysfunction, phosphodiesterase type 5 inhibitors (PDE5i), e.g. sildenafil, are efficacious in many patients with erectile dysfunction of vascular origin, but this therapy is insufficient in approximately 30-40% of men with erectile dysfunction where there is also a neuronal affection. There is a demand of novel approaches to treat the condition. We review the possibility of modulating the dopaminergic pathways to improve erectile function. Dopamine D1 (D1 , D5 )-and D2 (D2 -D4 )-like receptors in the paraventricular area, the medial preoptic area, the spinal cord, and in the erectile tissue are involved in erection, and several agonists developed for treatment of Parkinson's disease are associated with increased libido...
August 19, 2016: Basic & Clinical Pharmacology & Toxicology
John J Mulcahy
INTRODUCTION: Modern penile implants were introduced to the marketplace more than 40 years ago and were the first effective treatment of organic erectile dysfunction. The original devices were effective in restoring erections but were prone to early malfunction. AIM: This article describes the penile implants tested in clinical trials and chronicles the changes implemented by penile implant vendors in perfecting their products to improve device longevity, ease of use, and patient satisfaction...
April 2016: Sexual Medicine Reviews
Günay Yetik-Anacak, Aycan Dikmen, Ciro Coletta, Emma Mitidieri, Mehmet Dereli, Erminia Donnarumma, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino
Erectile dysfunction (ED) is considered as a marker for cardiovascular diseases. Nitric oxide (NO) deficiency is the major cause of erectile dysfunction (ED). The role of hydrogen sulfide (H2S) in erection has recently been recognized and is receiving attention as a pharmacological target. Several studies have focused on the effect of H2S on NO-dependent relaxation, but the role of NO on H2S in penile tissue has not been studied yet. Unlike NO, H2S is mainly synthesized from smooth muscle cells rather than endothelial cells...
August 10, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Chintan K Patel, Nelson Bennett
Erectile dysfunction adversely affects up to 20% of all men and is the most commonly treated sexual disorder. The public health implications of this condition are significant and represent a challenge for our healthcare system. The physiological pathways responsible for erections have been extensively studied, and much advancement has been made since the introduction of phosphodiesterase 5 inhibitors. Newer agents, such as dopaminergic and melanocortin receptor agonists, which target central erectogenic pathways, are under investigation...
2016: F1000Research
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